Chemokine Systems Link Obesity to Insulin Resistance
Tsuguhito Ota (Ota T)
Diabetes Metab J. 2013;37(3):165-172.   Published online 2013 Jun 14     DOI: https://doi.org/10.4093/dmj.2013.37.3.165
Citations to this article as recorded by Crossref logo
CX3CL1-CX3CR1 Signaling Deficiency Exacerbates Obesity-induced Inflammation and Insulin Resistance in Male Mice
Mayumi Nagashimada, Kazuki Sawamoto, Yinhua Ni, Hironori Kitade, Naoto Nagata, Liang Xu, Masuko Kobori, Naofumi Mukaida, Tatsuya Yamashita, Shuichi Kaneko, Tsuguhito Ota
Endocrinology.2021;[Epub]     CrossRef
Di(2-ethylhexyl)phthalate exposure exacerbates metabolic disorders in diet-induced obese mice
Jhih-Wei Hsu, Chung-Yi Nien, Hsin-Wei Chen, Feng-Yuan Tsai, Szu-Ching Yeh, Yung-Hsi Kao, Tsui-Chun Tsou
Food and Chemical Toxicology.2021; 156: 112439.     CrossRef
The Chemokine Systems at the Crossroads of Inflammation and Energy Metabolism in the Development of Obesity
Pei-Chi Chan, Po-Shiuan Hsieh
International Journal of Molecular Sciences.2021; 22(24): 13528.     CrossRef
Non-alcoholic fatty liver disease: a multi-system disease influenced by ageing and sex, and affected by adipose tissue and intestinal function
Josh Bilson, Jaswinder K. Sethi, Christopher D. Byrne
Proceedings of the Nutrition Society.2021; : 1.     CrossRef
β-Neoendorphin Enhances Wound Healing by Promoting Cell Migration in Keratinocyte
Dong Joo Yang, Sang Hyun Moh, Yun-Hee Choi, Ki Woo Kim
Molecules.2020; 25(20): 4640.     CrossRef
Transcriptome Analysis of Testis from HFD-Induced Obese Rats (Rattus norvigicus) Indicated Predisposition for Male Infertility
Ahmed M. El-Shehawi, Samir El-Shazly, Mohamed Ahmed, Mohamed Alkafafy, Samy Sayed, Samy Farouk, Saqer S. Alotaibi, Mona M. Elseehy
International Journal of Molecular Sciences.2020; 21(18): 6493.     CrossRef
Anti-Obesity Effects of Petasites japonicus (Meowi) Ethanol Extract on RAW 264.7 Macrophages and 3T3-L1 Adipocytes and Its Characterization of Polyphenolic Compounds
Eun Mi Ahn, Gelila Asamenew, Heon Woong Kim, Sang Hoon Lee, Seon-Mi Yoo, Soo-Muk Cho, Youn-Soo Cha, Min-Sook Kang
Nutrients.2020; 12(5): 1261.     CrossRef
Polymorphisms in miRNA binding sites involved in metabolic diseases in mice and humans
Pascal Gottmann, Meriem Ouni, Lisa Zellner, Markus Jähnert, Kilian Rittig, Dirk Walther, Annette Schürmann
Scientific Reports.2020;[Epub]     CrossRef
Asthma and metabolic syndrome: a comprehensive systematic review and meta-analysis of observational studies
Nahid Karamzad, Neda Izadi, Sarvin Sanaie, Elham Ahmadian, Aziz Eftekhari, Mark J.M. Sullman, Saeid Safiri
Journal of Cardiovascular and Thoracic Research.2020; 12(2): 120.     CrossRef
Elevated adipose tissue associated IL-2 expression in obesity correlates with metabolic inflammation and insulin resistance
Shihab Kochumon, Ashraf Al Madhoun, Fatema Al-Rashed, Reeby Thomas, Sardar Sindhu, Ebaa Al-Ozairi, Fahd Al-Mulla, Rasheed Ahmad
Scientific Reports.2020;[Epub]     CrossRef
Obesity-related hypoxia via miR-128 decreases insulin-receptor expression in human and mouse adipose tissue promoting systemic insulin resistance
Biagio Arcidiacono, Eusebio Chiefari, Anna Foryst-Ludwig, Giuseppe Currò, Giuseppe Navarra, Francesco S. Brunetti, Maria Mirabelli, Domenica M. Corigliano, Ulrich Kintscher, Domenico Britti, Vincenzo Mollace, Daniela P. Foti, Ira D. Goldfine, Antonio Brun
EBioMedicine.2020; 59: 102912.     CrossRef
Chemokines and their association with body mass index among healthy Saudis
Steve Harakeh, Gauthaman Kalamegam, Peter N. Pushparaj, Ahmed Al-Hejin, Sulaiman M. Alfadul, Turki Al Amri, Salah Barnawi, Hadeel Al Sadoun, Ahmed A. Mirza, Esam Azhar
Saudi Journal of Biological Sciences.2020; 27(1): 6.     CrossRef
New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions
Bei Guo, Tongtian Zhuang, Feng Xu, Xiao Lin, Fuxingzi Li, Su-Kang Shan, Feng Wu, Jia-Yu Zhong, Yi Wang, Ming-Hui Zheng, Qiu-Shuang Xu, Ullah Muhammad Hasnain Ehsan, Ling-Qing Yuan
Frontiers in Physiology.2020;[Epub]     CrossRef
Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic β-Cells to Type 2 Diabetes
Petr Ježek, Martin Jabůrek, Lydie Plecitá-Hlavatá
Antioxidants & Redox Signaling.2019; 31(10): 722.     CrossRef
Interleukin-22 Induces the Infiltration of Visceral Fat Tissue by a Discrete Subset of Duffy Antigen Receptor for Chemokine-Positive M2-Like Macrophages in Response to a High Fat Diet
Eun-Young Kim, Hye Mi Noh, Bongkun Choi, Ji-Eun Park, Ji-Eun Kim, Youngsaeng Jang, Hyung Keun Lee, Eun-Ju Chang
Cells.2019; 8(12): 1587.     CrossRef
The chemokine system and its role in obesity
Wenhua Xue, Zhirui Fan, Lifeng Li, Jingli Lu, Yunkai Zhai, Jie Zhao
Journal of Cellular Physiology.2019; 234(4): 3336.     CrossRef
Inonotus sanghuang Polyphenols Attenuate Inflammatory Response Via Modulating the Crosstalk Between Macrophages and Adipocytes
Mengdi Zhang, Yu Xie, Xing Su, Kun Liu, Yijie Zhang, Wuyan Pang, Junpeng Wang
Frontiers in Immunology.2019;[Epub]     CrossRef
Therapeutic Effects of Adipose Stem Cells from Diabetic Mice for the Treatment of Type 2 Diabetes
Mengmeng Wang, Lili Song, Charlie Strange, Xiao Dong, Hongjun Wang
Molecular Therapy.2018; 26(8): 1921.     CrossRef
Inflammatory Cytokine Profiles in Visceral and Subcutaneous Adipose Tissues of Obese Patients Undergoing Bariatric Surgery Reveal Lack of Correlation With Obesity or Diabetes
Volatiana Rakotoarivelo, Gregory Lacraz, Marian Mayhue, Christine Brown, Diane Rottembourg, Julie Fradette, Subburaj Ilangumaran, Alfredo Menendez, Marie-France Langlois, Sheela Ramanathan
EBioMedicine.2018; 30: 237.     CrossRef
Resveratrol reduces the inflammatory response in adipose tissue and improves adipose insulin signaling in high-fat diet-fed mice
Shibin Ding, Jinjin Jiang, Zhe Wang, Guofu Zhang, Jianli Yin, Xiaoya Wang, Sui Wang, Zengli Yu
PeerJ.2018; 6: e5173.     CrossRef
Dual CCR2/5 Antagonist Attenuates Obesity-Induced Insulin Resistance by Regulating Macrophage Recruitment and M1/M2 Status
Ji Hye Huh, Hong Min Kim, Eun Soo Lee, Mi Hye Kwon, Bo Ra Lee, Hyun-Jeong Ko, Choon Hee Chung
Obesity.2018; 26(2): 378.     CrossRef
Rosiglitazone Elicits an Adiponectin-Mediated Insulin-Sensitizing Action at the Adipose Tissue-Liver Axis in Otsuka Long-Evans Tokushima Fatty Rats
Jia Li, Yao-Ming Xue, Bo Zhu, Yong-Hua Pan, Yan Zhang, Chunxia Wang, Yuhao Li
Journal of Diabetes Research.2018; 2018: 1.     CrossRef
Myeloid-specific deletion of thrombospondin 1 protects against inflammation and insulin resistance in long-term diet-induced obese male mice
Hasiyet Memetimin, Dong Li, Kaiyuan Tan, Changcheng Zhou, Ying Liang, Yadi Wu, Shuxia Wang
American Journal of Physiology-Endocrinology and Metabolism.2018; 315(6): E1194.     CrossRef
From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions
Tiziana Caputo, Federica Gilardi, Béatrice Desvergne
FEBS Letters.2017; 591(19): 3061.     CrossRef
Effects of Karela (Bitter Melon; Momordica charantia) on genes of lipids and carbohydrates metabolism in experimental hypercholesterolemia: biochemical, molecular and histopathological study
Dalia Yossri Saad, Mohamed Mohamed Soliman, Ahmed A. Baiomy, Magdy Hassan Yassin, Hanan Basiouni El-Sawy
BMC Complementary and Alternative Medicine.2017;[Epub]     CrossRef
Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet–induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles
Chun-Chung Wang, Jui-Hung Yen, Yi-Cheng Cheng, Chia-Yu Lin, Cheng-Ta Hsieh, Rung-Jiun Gau, Shu-Jiau Chiou, Hwan-You Chang
Food & Nutrition Research.2017; 61(1): 1379861.     CrossRef
Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB
Leen Catrysse, Geert van Loo
Trends in Cell Biology.2017; 27(6): 417.     CrossRef
RETRACTED ARTICLE: TREM-1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population
Saravanan Subramanian, Pradeep K. Pallati, Poonam Sharma, Devendra K. Agrawal, Kalyana C. Nandipati
Journal of Translational Medicine.2017;[Epub]     CrossRef
The Role of Heparin Cofactor Ⅱ in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice
Kiyoe Kurahashi, Seika Inoue, Sumiko Yoshida, Yasumasa Ikeda, Kana Morimoto, Ryoko Uemoto, Kazue Ishikawa, Takeshi Kondo, Tomoyuki Yuasa, Itsuro Endo, Masato Miyake, Seiichi Oyadomari, Toshio Matsumoto, Masahiro Abe, Hiroshi Sakaue, Ken-ichi Aihara
Journal of Atherosclerosis and Thrombosis.2017; 24(12): 1215.     CrossRef
Pure total flavonoids from citrus improve non-alcoholic fatty liver disease by regulating TLR/CCL signaling pathway: A preliminary high-throughput ‘omics’ study
Liyan Wu, Maoxiang Yan, Jianping Jiang, Beihui He, Wei Hong, Zhiyun Chen
Biomedicine & Pharmacotherapy.2017; 93: 316.     CrossRef
The association between metabolic health, obesity phenotype and the risk of breast cancer
Yong‐Moon Mark Park, Alexandra J. White, Hazel B. Nichols, Katie M. O'Brien, Clarice R. Weinberg, Dale P. Sandler
International Journal of Cancer.2017; 140(12): 2657.     CrossRef
Immune regulation of glucose and lipid metabolism
Tsuguhito Ota
Diabetology International.2017; 8(3): 257.     CrossRef
Distinguishing features of body mass index and psoriasis in men and women in Japan: A hospital-based case-control study
Reiko Naito, Shinichi Imafuku
The Journal of Dermatology.2016; 43(12): 1406.     CrossRef
Change in Serum Bilirubin Level as a Predictor of Incident Metabolic Syndrome
You-Bin Lee, Seung-Eun Lee, Ji Eun Jun, Jae Hwan Jee, Ji Cheol Bae, Sang-Man Jin, Jae Hyeon Kim, Sheng-Nan Lu
PLOS ONE.2016; 11(12): e0168253.     CrossRef
Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked?
Kanwal Rehman, Muhammad Sajid Hamid Akash
Journal of Biomedical Science.2016;[Epub]     CrossRef
Chemokine genetic polymorphism in human health and disease
Tabish Qidwai
Immunology Letters.2016; 176: 128.     CrossRef
The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction
Che-Pei Kung, Julia I-Ju Leu, Subhasree Basu, Sakina Khaku, Frederick Anokye-Danso, Qin Liu, Donna L. George, Rexford S. Ahima, Maureen E. Murphy
Cell Reports.2016; 14(10): 2413.     CrossRef
E3 ubiquitin ligases as novel targets for inflammatory diseases
Santosh Kumar Goru, Anuradha Pandey, Anil Bhanudas Gaikwad
Pharmacological Research.2016; 106: 1.     CrossRef
Immune and Inflammatory Signaling Pathways in Exercise and Obesity
Karsten Krüger, Frank C. Mooren, Klaus Eder, Robert Ringseis
American Journal of Lifestyle Medicine.2016; 10(4): 268.     CrossRef
CCL2 level is elevated with metabolic syndrome and CXCL10 level is correlated with visceral fat area in obese children
Masahiro Ishii, Shunsuke Araki, Motohide Goto, Yukiyo Yamamoto, Koichi Kusuhara
Endocrine Journal.2016; 63(9): 795.     CrossRef
CCL2 gene polymorphism is associated with post-transplant diabetes mellitus
Ewa Dabrowska-Zamojcin, Maciej Romanowski, Violetta Dziedziejko, Agnieszka Maciejewska-Karlowska, Marek Sawczuk, Krzysztof Safranow, Leszek Domanski, Andrzej Pawlik
International Immunopharmacology.2016; 32: 62.     CrossRef
Blocking CXCR7-mediated adipose tissue macrophages chemotaxis attenuates insulin resistance and inflammation in obesity
Hongxia Peng, Hu Zhang, Honglei Zhu
Biochemical and Biophysical Research Communications.2016; 479(4): 649.     CrossRef
A brief glimpse at CTRP3 and CTRP9 in lipid metabolism and cardiovascular protection
Yang Yang, Yue Li, Zhiqiang Ma, Shuai Jiang, Chongxi Fan, Wei Hu, Dongjin Wang, Shouyin Di, Yang Sun, Wei Yi
Progress in Lipid Research.2016; 64: 170.     CrossRef
Obesity-associated cancer: an immunological perspective
Melissa J. Conroy, Margaret R. Dunne, Claire L. Donohoe, John V. Reynolds
Proceedings of the Nutrition Society.2016; 75(2): 125.     CrossRef
The Dietary Isoflavone Daidzein Reduces Expression of Pro-Inflammatory Genes through PPARα/γ and JNK Pathways in Adipocyte and Macrophage Co-Cultures
Yuri Sakamoto, Junko Kanatsu, Mariko Toh, Ayano Naka, Kazuo Kondo, Kaoruko Iida, Makoto Makishima
PLOS ONE.2016; 11(2): e0149676.     CrossRef
Response of gut microbiota and inflammatory status to bitter melon (Momordica charantia L.) in high fat diet induced obese rats
Juan Bai, Ying Zhu, Ying Dong
Journal of Ethnopharmacology.2016; 194: 717.     CrossRef
SIRT1 and insulin resistance
Yue Cao, Xinli Jiang, Huijie Ma, Yuling Wang, Peng Xue, Yan Liu
Journal of Diabetes and its Complications.2016; 30(1): 178.     CrossRef
CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance
Milton-Omar Guzmán-Ornelas, Marcelo Heron Petri, Mónica Vázquez-Del Mercado, Efraín Chavarría-Ávila, Fernanda-Isadora Corona-Meraz, Sandra-Luz Ruíz-Quezada, Perla-Monserrat Madrigal-Ruíz, Jorge Castro-Albarrán, Flavio Sandoval-García, Rosa-Elena Navarro-H
Journal of Diabetes Research.2016; 2016: 1.     CrossRef
Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice
Jongkil Kim, Kunho Chung, Changseon Choi, Jagadish Beloor, Irfan Ullah, Nahyeon Kim, Kuen Yong Lee, Sang-Kyung Lee, Priti Kumar
Molecular Therapy - Nucleic Acids.2016; 5: e280.     CrossRef
Les adipokines : état des lieux et nouveautés
J.-P. Bastard, C. Bastard, S. Fellahi, C. Vatier, J. Capeau, B. Fève
Obésité.2016; 11(3): 181.     CrossRef
TM-25659-Induced Activation of FGF21 Level Decreases Insulin Resistance and Inflammation in Skeletal Muscle via GCN2 Pathways
Molecules and Cells.2015; 38(12): 1037.     CrossRef
Aromatase Controls Sjögren Syndrome–Like Lesions through Monocyte Chemotactic Protein-1 in Target Organ and Adipose Tissue–Associated Macrophages
Akihiko Iwasa, Rieko Arakaki, Naoko Honma, Aya Ushio, Akiko Yamada, Tomoyuki Kondo, Emi Kurosawa, Satoko Kujiraoka, Takaaki Tsunematsu, Yasusei Kudo, Eiji Tanaka, Noriko Yoshimura, Nobuhiro Harada, Yoshio Hayashi, Naozumi Ishimaru
The American Journal of Pathology.2015; 185(1): 151.     CrossRef
Macrophage Migration Inhibitory Factor Promoter Polymorphisms (−794 CATT5–8and −173 G>C): Relationship with mRNA Expression and Soluble MIF Levels in Young Obese Subjects
Inés Matia-García, Lorenzo Salgado-Goytia, José F. Muñoz-Valle, Samuel García-Arellano, Jorge Hernández-Bello, Aralia B. Salgado-Bernabé, Isela Parra-Rojas
Disease Markers.2015; 2015: 1.     CrossRef
Niche-Dependent Regulations of Metabolic Balance in High-Fat Diet–Induced Diabetic Mice by Mesenchymal Stromal Cells
Andrea Tung-Qian Ji, Yun-Chuang Chang, Yun-Ju Fu, Oscar K. Lee, Jennifer H. Ho
Diabetes.2015; 64(3): 926.     CrossRef
Simvastatin Does Not Reduce Chemokine Production in Obesity Without Comorbidities
Karla Silva Fernandes, Samantha Ribeiro Béla, Vanessa L. Andrade, Tatiane Figueiredo de Moraes, Olindo de Assis Martins-Filho, Valéria Cristina Sandrim
Inflammation.2015; 38(3): 1297.     CrossRef
Asthma and metabolic syndrome: Current knowledge and future perspectives
Laura Serafino-Agrusa
World Journal of Clinical Cases.2015; 3(3): 285.     CrossRef
Analysis of the correlation between serum resistin and the variability of erythropoietin responsiveness in patients with chronic kidney disease
HONGHAO ZHANG, XIUJIANG LI, YANHONG KAN, FAN YANG, YUE HOU, YUJUN DU
Experimental and Therapeutic Medicine.2015; 10(5): 1925.     CrossRef
Preventive effects of bitter melon (Momordica charantia) against insulin resistance and diabetes are associated with the inhibition of NF-κB and JNK pathways in high-fat-fed OLETF rats
Soo Jin Yang, Jung Mook Choi, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Cheol-Young Park
The Journal of Nutritional Biochemistry.2015; 26(3): 234.     CrossRef
Association of serum angiopoietin-like protein 2 with carotid intima-media thickness in subjects with type 2 diabetes
Chang Hee Jung, Woo Je Lee, Min Jung Lee, Yu Mi Kang, Jung Eun Jang, Jaechan Leem, Yoo La Lee, So Mi Seol, Hae Kyeong Yoon, Joong-Yeol Park
Cardiovascular Diabetology.2015;[Epub]     CrossRef
Effects of intermittent exercise on biomarkers of cardiovascular risk in night shift workers
Seung-Taek Lim, Seok-Ki Min, Yoo-Chan Kwon, Sang-Kab Park, Hyuntae Park
Atherosclerosis.2015; 242(1): 186.     CrossRef
Milk-derived peptide Val-Pro-Pro (VPP) inhibits obesity-induced adipose inflammation via an angiotensin-converting enzyme (ACE) dependent cascade
Yoko Sawada, Yuri Sakamoto, Mariko Toh, Nozomi Ohara, Yuiko Hatanaka, Ayano Naka, Yoshimi Kishimoto, Kazuo Kondo, Kaoruko Iida
Molecular Nutrition & Food Research.2015; 59(12): 2502.     CrossRef
Ubiquitin ligase Cbl-b and obesity-induced insulin resistance [Review]
Tomoki Abe, Katsuya Hirasaka, Shohei Kohno, Arisa Ochi, Naoko Yamagishi, Ayako Ohno, Shigetada Teshima-Kondo, Takeshi Nikawa
Endocrine Journal.2014; 61(6): 529.     CrossRef
Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet‐induced obesity
Longbiao Yao, Janet Heuser‐Baker, Oana Herlea‐Pana, Nan Zhang, Luke I. Szweda, Timothy M. Griffin, Jana Barlic‐Dicen
The FASEB Journal.2014; 28(10): 4534.     CrossRef
Unprotected daily sun exposure is differently associated with central adiposity and beta-cell dysfunction by gender: The Korean national health and nutrition examination survey (KNHANES) V
Jung Hun Ohn, In Ho Kwon, Juri Park, Ohk Hyun Ryu, Seong Jin Lee, Doo-Man Kim, Sung-Hee Ihm, Moon-Gi Choi, Hyung Joon Yoo, Eun-Gyoung Hong
Environmental Research.2014; 133: 253.     CrossRef
Anti-adipogenic effect of mulberry leaf ethanol extract in 3T3-L1 adipocytes
Soo Jin Yang, Na-Young Park, Yunsook Lim
Nutrition Research and Practice.2014; 8(6): 613.     CrossRef
What We Talk About When We Talk About Fat
Evan D. Rosen, Bruce M. Spiegelman
Cell.2014; 156(1-2): 20.     CrossRef
Effect of diabetes on the relation between troponin T and inflammatory markers in patients on hemodialysis
Emília Mácsai, Ilona Németh, Attila Benke, Gyula Dávid
Orvosi Hetilap.2014; 155(16): 627.     CrossRef
Active ingredients from natural botanicals in the treatment of obesity
W.-L. Zhang, L. Zhu, J.-G. Jiang
Obesity Reviews.2014; 15(12): 957.     CrossRef
Hypertrophic Obesity and Subcutaneous Adipose Tissue Dysfunction
Anna Meiliana, Andi Wijaya
The Indonesian Biomedical Journal.2014; 6(2): 79.     CrossRef
Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus
Nailú Angélica Sinicato, Mariana Postal, Fernando Augusto Peres, Karina de Oliveira Peliçari, Roberto Marini, Allan de Oliveira dos Santos, Celso Dario Ramos, Simone Appenzeller
Journal of Immunology Research.2014; 2014: 1.     CrossRef
Assessment of the number and function of macrophages in the placenta of gestational diabetes mellitus patients
Jun Yu, Yong Zhou, Juan Gui, Ai-zhen Li, Xiao-ling Su, Ling Feng
Journal of Huazhong University of Science and Technology [Medical Sciences].2013; 33(5): 725.     CrossRef