Diabetes & Metabolism Journal

Original Articles

Lifestyle and Behavioral Interventions
The Preventive Effect of Physical Activity on Gestational Diabetes Mellitus: A Korean Longitudinal Prospective Cohort Study: Ji Hyae Lim, Min Hyoung Kim, Hye-Ji Han, Su Ji Yang, Myung-Gwan Kim, Hyun Jung Lee, You Jung Han, Jin Hoon Chung, Dong Wook Kwak, Seongwoo Yang, Moon Young Kim, Hyun Mee Ryu; Received May 30, 2024 Accepted December 3, 2024 Published online April 23, 2025; DOI: https://doi.org/10.4093/dmj.2024.0280 [Epub ahead of print]

711 View
48 Download
1 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
To assess longitudinally physical activity patterns and intensity from pre-pregnancy to postpartum and evaluate the association between timing and type of physical activity and the development of gestational diabetes mellitus (GDM).
Methods
The Korean Pregnancy Outcome Study (KPOS) is a prospective cohort study conducted from 2013 to 2017. Our study included 3,457 participants with singleton pregnancies in KPOS, classified according to the pregnancy outcome: GDM (n=231) and normal (n=3,226). Physical activity data were collected at five time points using the short form of the International Physical Activity Questionnaire: before pregnancy, at 12, 24, and 36 gestational weeks (GW), and 6–8 weeks postpartum. Pre-pregnancy physical activity was collected through recall at 12 GW.
Results
Maternal age, pre-pregnancy body mass index, educational status, smoking, mini dietary assessment index, first-degree family history of diabetes, hypertension, parity, pre-existing GDM, and previous macrosomia showed significant differences between the GDM group and the normal group (P<0.05 for all). Pre-pregnancy muscle-strengthening activity was significantly associated with a lower risk of GDM (adjusted odds ratio, 0.46; 95% confidence interval, 0.25 to 0.85).
Conclusion
These findings suggest that physical activity, such as muscle-strengthening activities before pregnancy, could be a preventive strategy to reduce GDM risk. Although the study does not provide evidence that physical activity during pregnancy and postpartum reduces GDM risk, it offers significant insights into the importance of maintaining a healthy level of physical activity from pre-pregnancy to prevent GDM.

Citations

Citations to this article as recorded by

Pre-Conception Physical Activity and the Risk of Gestational Diabetes Mellitus: Findings from the BORN 2020 Study
Antigoni Tranidou, Antonios Siargkas, Ioannis Tsakiridis, Emmanuela Magriplis, Aikaterini Apostolopoulou, Georgia Koutsouki, Michail Chourdakis, Themistoklis Dagklis
Nutrients.2025; 17(11): 1832. CrossRef

Metabolic Risk/Epidemiology
Pregravid Weight Gain Is Associated with an Increased Risk of Gestational Diabetes: Sunmie Kim, Kyungdo Han, Su-Yeon Choi, Min Joo Kim, Sun Young Yang, Seung Ho Choi, Jeong Yoon Yim, Jin Ju Kim, Min-Jeong Kim; Received August 19, 2024 Accepted November 15, 2024 Published online March 26, 2025; DOI: https://doi.org/10.4093/dmj.2024.0491 [Epub ahead of print]

978 View
23 Download
1 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Studies have reported a significant association between pregravid weight gain and the subsequent development of gestational diabetes mellitus (GDM) in various populations. The current study aims to investigate this relationship using data from the Korean National Health Insurance Service database.
Methods
We conducted a retrospective nationwide population-based cohort study, involving 159,798 women who gave birth between 2015 and 2017 and had undergone two national health screening examinations: 1 year (index checkup) and 3 years before (baseline checkup) their respective estimated conception date. Participants were categorized into five groups based on the extent of weight change between the two examinations: more than 10%, 5% to 10%, –5% to 5% (reference group), –10% to –5%, and more than –10%. The study assessed the association between pregravid weight change and GDM risk.
Results
Among the 146,363 women analyzed, 11,012 (7.52%) were diagnosed with GDM. Multiple regression analysis revealed that women who gained 5% to 10% of their weight had a 12% increased risk of GDM (adjusted odds ratio [aOR], 1.12; 95% confidence interval [CI], 1.06 to 1.17), while those who gained ≥10% had a 34% higher risk (aOR, 1.34; 95% CI, 1.26 to 1.43). Notably, pregravid weight gain was particularly associated with GDM risk in non-obese or non-metabolic syndrome groups at index checkup.
Conclusion
Pregravid weight gain showed a dose-dependent association with a higher risk of GDM. This association was more pronounced in non-obese individuals emphasizing the importance of minimizing pregravid weight gain for GDM prevention, even in non-obese women.

Citations

Citations to this article as recorded by

Advancing Early Prediction of Gestational Diabetes Mellitus with Circular RNA Biomarkers
Joon Ho Moon, Sung Hee Choi
Diabetes & Metabolism Journal.2025; 49(3): 403. CrossRef

Metabolic Risk/Epidemiology
Validating Multicenter Cohort Circular RNA Model for Early Screening and Diagnosis of Gestational Diabetes Mellitus: Shuo Ma, Yaya Chen, Zhexi Gu, Jiwei Wang, Fengfeng Zhao, Yuming Yao, Gulinaizhaer Abudushalamu, Shijie Cai, Xiaobo Fan, Miao Miao, Xun Gao, Chen Zhang, Guoqiu Wu; Diabetes Metab J. 2025;49(3):462-474. Published online February 21, 2025; DOI: https://doi.org/10.4093/dmj.2024.0205

1,142 View
100 Download
1 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Gestational diabetes mellitus (GDM) is a metabolic disorder posing significant risks to maternal and infant health, with a lack of effective early screening markers. Therefore, identifying early screening biomarkers for GDM with higher sensitivity and specificity is urgently needed.
Methods
High-throughput sequencing was employed to screen for key circular RNAs (circRNAs), which were then evaluated using reverse transcription quantitative polymerase chain reaction. Logistic regression analysis was conducted to examine the relationship between clinical characteristics, circRNA expression, and adverse pregnancy outcomes. The diagnostic accuracy of circRNAs for early and mid-pregnancy GDM was assessed using receiver operating characteristic curves. Pearson correlation analysis was utilized to explore the relationship between circRNA levels and oral glucose tolerance test results. A predictive model for early GDM was established using logistic regression.
Results
Significant alterations in circRNA expression profiles were detected in GDM patients, with hsa_circ_0031560 and hsa_ circ_0000793 notably upregulated during the first and second trimesters. These circRNAs were associated with adverse pregnancy outcomes and effectively differentiated GDM patients, with second trimester cohorts achieving an area under the curve (AUC) of 0.836. In first trimester cohorts, these circRNAs identified potential GDM patients with AUCs of 0.832 and 0.765, respectively. The early GDM prediction model achieved an AUC of 0.904, validated in two independent cohorts.
Conclusion
Hsa_circ_0031560, hsa_circ_0000793, and the developed model serve as biomarkers for early prediction or midterm diagnosis of GDM, offering clinical tools for early GDM screening.

Citations

Citations to this article as recorded by

Advancing Early Prediction of Gestational Diabetes Mellitus with Circular RNA Biomarkers
Joon Ho Moon, Sung Hee Choi
Diabetes & Metabolism Journal.2025; 49(3): 403. CrossRef

Genetics
Identification and Potential Clinical Utility of Common Genetic Variants in Gestational Diabetes among Chinese Pregnant Women: Claudia Ha-ting Tam, Ying Wang, Chi Chiu Wang, Lai Yuk Yuen, Cadmon King-poo Lim, Junhong Leng, Ling Wu, Alex Chi-wai Ng, Yong Hou, Kit Ying Tsoi, Hui Wang, Risa Ozaki, Albert Martin Li, Qingqing Wang, Juliana Chung-ngor Chan, Yan Chou Ye, Wing Hung Tam, Xilin Yang, Ronald Ching-wan Ma; Diabetes Metab J. 2025;49(1):128-143. Published online September 20, 2024; DOI: https://doi.org/10.4093/dmj.2024.0139

3,779 View
171 Download
1 Web of Science
3 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
The genetic basis for hyperglycaemia in pregnancy remain unclear. This study aimed to uncover the genetic determinants of gestational diabetes mellitus (GDM) and investigate their applications.
Methods
We performed a meta-analysis of genome-wide association studies (GWAS) for GDM in Chinese women (464 cases and 1,217 controls), followed by de novo replications in an independent Chinese cohort (564 cases and 572 controls) and in silico replication in European (12,332 cases and 131,109 controls) and multi-ethnic populations (5,485 cases and 347,856 controls). A polygenic risk score (PRS) was derived based on the identified variants.
Results
Using the genome-wide scan and candidate gene approaches, we identified four susceptibility loci for GDM. These included three previously reported loci for GDM and type 2 diabetes mellitus (T2DM) at MTNR1B (rs7945617, odds ratio [OR], 1.64; 95% confidence interval [CI], 1.38 to 1.96), CDKAL1 (rs7754840, OR, 1.33; 95% CI, 1.13 to 1.58), and INS-IGF2-KCNQ1 (rs2237897, OR, 1.48; 95% CI, 1.23 to 1.79), as well as a novel genome-wide significant locus near TBR1-SLC4A10 (rs117781972, OR, 2.05; 95% CI, 1.61 to 2.62; P_meta=7.6×10^-9), which has not been previously reported in GWAS for T2DM or glycaemic traits. Moreover, we found that women with a high PRS (top quintile) had over threefold (95% CI, 2.30 to 4.09; P_meta=3.1×10^-14) and 71% (95% CI, 1.08 to 2.71; P=0.0220) higher risk for GDM and abnormal glucose tolerance post-pregnancy, respectively, compared to other individuals.
Conclusion
Our results indicate that the genetic architecture of glucose metabolism exhibits both similarities and differences between the pregnant and non-pregnant states. Integrating genetic information can facilitate identification of pregnant women at a higher risk of developing GDM or later diabetes.

Citations

Citations to this article as recorded by

GWAS in Gestational Diabetes Mellitus: Research Advances
Dikun Zhou, Z. Shi, A.H. Hashash, Z.H. Khan
BIO Web of Conferences.2025; 174: 01018. CrossRef
Advancing Early Prediction of Gestational Diabetes Mellitus with Circular RNA Biomarkers
Joon Ho Moon, Sung Hee Choi
Diabetes & Metabolism Journal.2025; 49(3): 403. CrossRef
Hexokinase Domain Containing 1 (HKDC1) Gene Variants and Their Association With Gestational Diabetes Mellitus: A Mini-Review
Sekar Kanthimathi, Polina Popova, Viswanathan Mohan, Wesley Hannah, Ranjit Mohan Anjana, Venkatesan Radha
Journal of Diabetology.2024; 15(4): 354. CrossRef

Review

Metabolic Risk/Epidemiology
Gestational Diabetes Mellitus and Its Implications across the Life Span: Brandy Wicklow, Ravi Retnakaran; Diabetes Metab J. 2023;47(3):333-344. Published online February 8, 2023; DOI: https://doi.org/10.4093/dmj.2022.0348

22,929 View
1,185 Download
32 Web of Science
37 Crossref

Abstract PDF PubReader ePub

Gestational diabetes mellitus (GDM) has historically been perceived as a medical complication of pregnancy that also serves as a harbinger of maternal risk of developing type 2 diabetes mellitus (T2DM) in the future. In recent decades, a growing body of evidence has detailed additional lifelong implications that extend beyond T2DM, including an elevated risk of ultimately developing cardiovascular disease. Furthermore, the risk factors that mediate this lifetime cardiovascular risk are evident not only after delivery but are present even before the pregnancy in which GDM is first diagnosed. The concept thus emerging from these data is that the diagnosis of GDM enables the identification of women who are already on an enhanced track of cardiometabolic risk that starts early in life. Studies of the offspring of pregnancies complicated by diabetes now suggest that the earliest underpinnings of this cardiometabolic risk profile may be determined in utero and may first manifest clinically in childhood. Accordingly, from this perspective, GDM is now seen as a chronic metabolic disorder that holds implications across the life span of both mother and child.

Citations

Citations to this article as recorded by

The Value of lncRNAs as a Biomarker for the Diagnosis of Gestational Diabetes: A Meta-Analysis
Yang Fan, Xin Chen, Song Yang, Hongxia Tu, Youyi Zhang, Mingyi Wang, Jingying Jiang
Hormone and Metabolic Research.2025; 57(01): 67. CrossRef
Evidence-Based Care Practices for Children Exposed to a Diabetes-Complicated Pregnancy
Valerie C. Martinez, Jacqueline B. LaManna, Susan B. Quelly, Suzanne Hyer, Jean W. Davis, Carmen Giurgescu
The Journal for Nurse Practitioners.2025; 21(1): 105254. CrossRef
Genetic and epigenetic alterations associated with gestational diabetes mellitus and adverse neonatal outcomes
Amreen Shamsad, Tanu Gautam, Renu Singh, Monisha Banerjee
World Journal of Clinical Pediatrics.2025;[Epub] CrossRef
Untreated women with first trimester fasting glycaemia 92−125 mg/dL and risk of gestational diabetes mellitus in the 24−28th week OGTT: prevalence and predictors
Catarina Cidade-Rodrigues, Bruna Silva, Vânia Benido Silva, Catarina Chaves, Maria Luís Mazeda, Alexandra Araújo, Cláudia Machado, Catarina A. Pereira, Vânia Gomes, Odete Figueiredo, Anabela Melo, Anabela Ferreira, Mariana Martinho, Ana Morgado, Ana Saave
Acta Diabetologica.2025;[Epub] CrossRef
A Review of the Impact of Gestational Diabetes on Fetal Brain Development: An Update on Neurosonographic Markers During the Last Decade
Efthymios Oikonomou, Christos Chatzakis, Sofoklis Stavros, Anastasios Potiris, Konstantinos Nikolettos, Sotirios Sotiriou, Ekaterini Domali, Nikolaos Nikolettos, Alexandros Sotiriadis, Angeliki Gerede
Life.2025; 15(2): 210. CrossRef
Gestational Diabetes Mellitus: Mechanisms Underlying Maternal and Fetal Complications
Jooyeop Lee, Na Keum Lee, Joon Ho Moon
Endocrinology and Metabolism.2025; 40(1): 10. CrossRef
Unveiling Gestational Diabetes: An Overview of Pathophysiology and Management
Rahul Mittal, Karan Prasad, Joana R. N. Lemos, Giuliana Arevalo, Khemraj Hirani
International Journal of Molecular Sciences.2025; 26(5): 2320. CrossRef
In-patient expenditure between 2011 and 2021 for patients with type 2 diabetes mellitus: a hospital-based multicenter retrospective study in southwest China
Yuxin He, Juntao Tan, Qingzhu Tan, Xiao Zhang, Yunyu Liu, Yang Tang
Frontiers in Public Health.2025;[Epub] CrossRef
Knockdown of Aurora kinase B alleviates high glucose-triggered trophoblast cells damage and inflammation during gestational diabetes
Yuzhuo Ma, Yongyun Shi, Yujie Liu
Open Life Sciences.2025;[Epub] CrossRef
Prediction of Gestational Diabetes Mellitus (GDM) risk in early pregnancy based on clinical data and ultrasound information: a nomogram
Tong Zhu, Lin Tang, Man Qin, Wen-Wen Wang, Ling Chen
BMC Medical Informatics and Decision Making.2025;[Epub] CrossRef
Metabolomic profiling reveals early biomarkers of gestational diabetes mellitus and associated hepatic steatosis
Youngae Jung, Seung Mi Lee, Jinhaeng Lee, Yeonjin Kim, Woojoo Lee, Ja Nam Koo, Ig Hwan Oh, Kue Hyun Kang, Byoung Jae Kim, Sun Min Kim, Jeesun Lee, Ji Hoi Kim, Yejin Bae, Sang Youn Kim, Gyoung Min Kim, Sae Kyung Joo, Dong Hyeon Lee, Joon Ho Moon, Bo Kyung
Cardiovascular Diabetology.2025;[Epub] CrossRef
Genetics and epigenetics in gestational diabetes contributing to type 2 diabetes
Dewei Kong, Oliwia Kowalik, Emma Garratt, Keith M. Godfrey, Shiao-Yng Chan, Adrian Kee Keong Teo
Trends in Endocrinology & Metabolism.2025;[Epub] CrossRef
Mechanisms of Fetal Overgrowth in Gestational Diabetes: The Potential Role of SOCS2
Luisa Hernández-Baraza, Yeray Brito-Casillas, Carmen Valverde-Tercedor, Carlota Recio, Leandro Fernández-Pérez, Borja Guerra, Ana M. Wägner
Nutrients.2025; 17(9): 1519. CrossRef
Mediating effect of osteocalcin underlying the link between insulin-like growth factor-I and gestational diabetes mellitus
Lingling Cui, Yuting Gao, Ruijie Sun, Zhiqian Li, Zhengya Zhang, Linpu Ji, Yibo Wang, Hua Ye, Luying Qin
BMC Pregnancy and Childbirth.2025;[Epub] CrossRef
Extracellular Vesicle-Mediated Network in the Pathogenesis of Obesity, Diabetes, Steatotic Liver Disease, and Cardiovascular Disease
Joonyub Lee, Won Gun Choi, Marie Rhee, Seung-Hwan Lee
Diabetes & Metabolism Journal.2025; 49(3): 348. CrossRef
Co-Designing a postpartum diabetes prevention program after gestational diabetes mellitus: A MoSCoW prioritization workshop exercise
Megan Racey, Paige Alliston, Diana Sherifali, Apishanthi Sriskandarajah, Katelyn Sushko, Lorraine Lipscombe
Diabetes Research and Clinical Practice.2025; 225: 112269. CrossRef
Circulating miR-4454 as a potential biomarker for the diagnosis of T2DM and the prediction value of comorbidity and complications in T2DM
Song Yang, Mei Wang, Qin Deng
BMC Endocrine Disorders.2025;[Epub] CrossRef
ATP5me alleviates high glucose-induced myocardial cell injury
Qingsha Hou, Fang Yan, Xiuling Li, Huanling Liu, Xiang Yang, Xudong Dong
International Immunopharmacology.2024; 129: 111626. CrossRef
Prevalence and Predictors of Gestational Diabetes Mellitus and Overt Diabetes in Pregnancy: A Secondary Analysis of Nationwide Data from India
Saurav Basu, Vansh Maheshwari, Rutul Gokalani, Chandrakant Lahariya
Preventive Medicine: Research & Reviews.2024; 1(1): 52. CrossRef
Serum betaine and dimethylglycine in mid-pregnancy and the risk of gestational diabetes mellitus: a case-control study
Ziqing Zhou, Yao Yao, Yanan Sun, Xin Wang, Shang Huang, Jianli Hou, Lijun Wang, Fengxiang Wei
Endocrine.2024; 85(2): 649. CrossRef
Quality assessment of videos on social media platforms related to gestational diabetes mellitus in China: A cross-section study
Qin-Yu Cai, Jing Tang, Si-Zhe Meng, Yi Sun, Xia Lan, Tai-Hang Liu
Heliyon.2024; 10(7): e29020. CrossRef
Association of VDR gene variant rs2228570-FokI with gestational diabetes mellitus susceptibility in Arab women
Maysa Alzaim, Mohammed G.A. Ansari, Abeer A. Al-Masri, Malak N.K. Khattak, Abir Alamro, Amani Alghamdi, Amal Alenad, Majed Alokail, Omar S. Al-Attas, Ahmad G. Al-Zahrani, Nasser M. Al-Daghri
Heliyon.2024; 10(11): e32048. CrossRef
Variations in the LINGO2 and GLIS3 Genes and Gene–Environment Interactions Increase Gestational Diabetes Mellitus Risk in Chinese Women
Xiao Huang, Weiwei Liang, Runqiu Yang, Lei Jin, Kai Zhao, Juan Chen, Xuejun Shang, Yuanzhong Zhou, Xin Wang, Hongsong Yu
Environmental Science & Technology.2024; 58(26): 11596. CrossRef
Pre-gestational diabetes mellitus, gestational diabetes mellitus, and its association with the MTHFR C677T polymorphism
Nga Thi Ngoc Pham, Chau Thi Ngoc Huynh, Ai Thuy Thuy Nguyen, Chuong Quoc Ho, Linh My Duong, Dung The Bui, Ha Hong Nguyen
Medicine.2024; 103(28): e38648. CrossRef
Amelioration of Insulin Resistance after Delivery Is Associated with Reduced Risk of Postpartum Diabetes in Women with Gestational Diabetes Mellitus
Heejun Son, Joon Ho Moon, Sung Hee Choi, Nam H. Cho, Soo Heon Kwak, Hak Chul Jang
Endocrinology and Metabolism.2024; 39(5): 701. CrossRef
Oral Wound Healing in Aging Population
Claudia Florina Bogdan-Andreescu, Andreea-Mariana Bănățeanu, Oana Botoacă, Carmen Liliana Defta, Cristian-Viorel Poalelungi, Anca Daniela Brăila, Constantin Marian Damian, Matei Georgian Brăila, Laurențiu Mihai Dȋră
Surgeries.2024; 5(4): 956. CrossRef
Relationship between life’s essential 8 and the risk of gestational diabetes among us adults
Lu Qin, Zhixing Fan, Qian Shi, Hao Hu, Fang Ma, Yanlin Huang, Fengzhi Tan
The Journal of Maternal-Fetal & Neonatal Medicine.2024;[Epub] CrossRef
The role of quercetin in NLRP3-associated inflammation
Jiaqi Wu, Tongtong Lv, Yu Liu, Yifan Liu, Yukun Han, Xin Liu, Xiaochun Peng, Fengru Tang, Jun Cai
Inflammopharmacology.2024; 32(6): 3585. CrossRef
A Systematic Patent Review (2008-2023) for Treatment in Pregnancy
Kélle Velasques Pereira, Camila Oliveira Pacheco, Izabel Almeida Alves, Sandra Elisa Haas
Current Medicinal Chemistry.2024; 31(38): 6288. CrossRef
Usefulness of Glycated Albumin Levels in Predicting the Maternal or Neonatal Complications of Gestational Diabetes Mellitus during Late Pregnancy in South Korea: A Retrospective Study
Jihan Kim, Sami Lee, Jong Sung Kim
Korean Journal of Family Medicine.2024;[Epub] CrossRef
Clinical Significance of miR-339-5p in Early Diagnosis and Predicting Pregnancy Outcome of Chinese Patients with Liver Injury in Pregnancy
Ying Wang, Lichao Yuan, Falong Hu, Huilan Yu, Qiaofang Yang, Xiujuan Zheng
Clinical and Experimental Obstetrics & Gynecology.2024;[Epub] CrossRef
Single and Joint Associations Between Blood Cell‐Based Inflammatory Indicator in Early Pregnancy and Risk of Gestational Diabetes Mellitus (GDM): A Prospective Cohort Study
Yanling Xiao, Haonan Zhang, Songlin An, Rui Yu, Jing Yang, Xingting Zheng, Nian Wu, Lin Tao, Dengqing Liao, Mingyu Deng, Zhongmei Hu, Yijun Liu, Qing Chen, Yuanzhong Zhou
American Journal of Reproductive Immunology.2024;[Epub] CrossRef
Gestational diabetes-combined excess weight gain exacerbates gut microbiota dysbiosis in newborns, associated with reduced abundance of Clostridium, Coriobacteriaceae, and Collinsella
Yunshan Xiao, Yuan Shi, Yan Ni, Meilan Ni, Yuxin Yang, Xueqin Zhang
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef
Untargeted metabolomics profiling of gestational diabetes mellitus: insights into early diagnosis and metabolic pathway alterations
Shereen M. Aleidi, Hiba Al Fahmawi, Reem H. AlMalki, Maha Al Mogren, Mohammad Alwahsh, Muhammad Mujammami, Michele Costanzo, Anas Abdel Rahman
Frontiers in Molecular Biosciences.2024;[Epub] CrossRef
Inflammation and decreased cardiovagal modulation are linked to stress and depression at 36th week of pregnancy in gestational diabetes mellitus
Manoharan Renugasundari, Gopal Krushna Pal, Latha Chaturvedula, Nivedita Nanda, K. T. Harichandrakumar, Thiyagarajan Durgadevi
Scientific Reports.2023;[Epub] CrossRef
Women with gestational diabetes mellitus, controlled for plasma glucose level, exhibit maternal and fetal dyslipidaemia that may warrant treatment
Barbara J. Meyer, Colin Cortie, Marloes Dekker-Nitert, Helen L. Barrett, Dilys J. Freeman
Diabetes Research and Clinical Practice.2023; 204: 110929. CrossRef
Pregnancy diet to prevent gestational diabetes: study design and dietary assessments
Sylvia H. Ley
The American Journal of Clinical Nutrition.2023; 118(5): 847. CrossRef

Original Articles

Basic Research
Long Non-Coding RNA TUG1 Attenuates Insulin Resistance in Mice with Gestational Diabetes Mellitus via Regulation of the MicroRNA-328-3p/SREBP-2/ERK Axis: Xuwen Tang, Qingxin Qin, Wenjing Xu, Xuezhen Zhang; Diabetes Metab J. 2023;47(2):267-286. Published online January 19, 2023; DOI: https://doi.org/10.4093/dmj.2021.0216

5,669 View
228 Download
10 Web of Science
11 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Long non-coding RNAs (lncRNAs) have been illustrated to contribute to the development of gestational diabetes mellitus (GDM). In the present study, we aimed to elucidate how lncRNA taurine upregulated gene 1 (TUG1) influences insulin resistance (IR) in a high-fat diet (HFD)-induced mouse model of GDM.
Methods
We initially developed a mouse model of HFD-induced GDM, from which islet tissues were collected for RNA and protein extraction. Interactions among lncRNA TUG1/microRNA (miR)-328-3p/sterol regulatory element binding protein 2 (SREBP-2) were assessed by dual-luciferase reporter assay. Fasting blood glucose (FBG), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), HOMA pancreatic β-cell function (HOMA-β), insulin sensitivity index for oral glucose tolerance tests (ISOGTT) and insulinogenic index (IGI) levels in mouse serum were measured through conducting gain- and loss-of-function experiments.
Results
Abundant expression of miR-328 and deficient expression of lncRNA TUG1 and SREBP-2 were characterized in the islet tissues of mice with HFD-induced GDM. LncRNA TUG1 competitively bound to miR-328-3p, which specifically targeted SREBP-2. Either depletion of miR-328-3p or restoration of lncRNA TUG1 and SREBP-2 reduced the FBG, FINS, HOMA-β, and HOMA-IR levels while increasing ISOGTT and IGI levels, promoting the expression of the extracellular signal-regulated kinase (ERK) signaling pathway-related genes, and inhibiting apoptosis of islet cells in GDM mice. Upregulation miR-328-3p reversed the alleviative effects of SREBP-2 and lncRNA TUG1 on IR.
Conclusion
Our study provides evidence that the lncRNA TUG1 may prevent IR following GDM through competitively binding to miR-328-3p and promoting the SREBP-2-mediated ERK signaling pathway inactivation.

Citations

Citations to this article as recorded by

Research Progress of Risk Factors Associated with Gestational Diabetes Mellitus
Zi-Jun Lin, Lian-Ping He, Cui-Ping Li
Endocrine, Metabolic & Immune Disorders - Drug Targets.2025; 25(2): 99. CrossRef
Stress-Related LncRNAs and Their Roles in Diabetes and Diabetic Complications
Lian Li, Yu-Qi Wu, Jin-E Yang
International Journal of Molecular Sciences.2025; 26(5): 2194. CrossRef
LncRNAs in oncogenic microenvironment: from threat to therapy
Dipanjan Roy, Bireswar Bhattacharya, Rudra Chakravarti, Prabhjot Singh, Mansi Arya, Anirban Kundu, Ajay Patil, Bhukiya Siva, Sunny Mehta, Tawsif Ahmed Kazi, Dipanjan Ghosh
Frontiers in Cell and Developmental Biology.2025;[Epub] CrossRef
SREBP2 as a central player in cancer progression: potential for targeted therapeutics
Ruiqi Chen, Tianyu Chen, Xiang Li, Junfeng Yu, Min Lin, Siqi Wen, Man Zhang, Jinchi Chen, Bei Yi, Huage Zhong, Zhao Li
Frontiers in Pharmacology.2025;[Epub] CrossRef
Diabetes and diabetic associative diseases: An overview of epigenetic regulations of TUG1
Mohammed Ageeli Hakami
Saudi Journal of Biological Sciences.2024; 31(5): 103976. CrossRef
Expression and Regulatory Ability of Long Non-Coding RNADLX6 Antisense RNA 1 in Gestational Diabetes Mellitus
Qiuhong Huang, Lichun Tang, Xiaohui Meng, Meiling Wen, Yin Qin, Jingjing Liu, Xuanxuan Luo, Rong Liang, Xia Dai
Clinical and Experimental Obstetrics & Gynecology.2024;[Epub] CrossRef
Chemerin alleviates the placental oxidative stress and improves fetal overgrowth of gestational diabetes mellitus mice induced by high fat diet
Xuan Zhou, Yi Jiang, Zizhuo Wang, Lijie Wei, Huiting Zhang, Chenyun Fang, Shenglan Zhu, Yuanyuan Du, Rui Su, Weikun Li, Zhenzhen He, Liangnan Zhang, Weidong Tan, Mengzhou He, Jun Yu, Shaoshuai Wang, Wencheng Ding, Ling Feng
Molecular Medicine.2024;[Epub] CrossRef
Effect of Tinospora cordifolia on gestational diabetes mellitus and its complications
Ritu Rani, Havagiray Chitme, Avinash Kumar Sharma
Women & Health.2023; 63(5): 359. CrossRef
Therapeutic Effect of Tinospora cordifolia (Willd) Extracts on Letrozole-Induced Polycystic Ovarian Syndrome and its Complications in Murine Model
Ritu Rani, Avinash Kumar Sharma, Havagiray R Chitme
Clinical Medicine Insights: Endocrinology and Diabetes.2023;[Epub] CrossRef
The role of ncRNA regulatory mechanisms in diseases—case on gestational diabetes
Dong Gao, Liping Ren, Yu-Duo Hao, Nalini Schaduangrat, Xiao-Wei Liu, Shi-Shi Yuan, Yu-He Yang, Yan Wang, Watshara Shoombuatong, Hui Ding
Briefings in Bioinformatics.2023;[Epub] CrossRef
lncRNA TUG1 as Potential Novel Biomarker for Prognosis of Cardiovascular Diseases
Habib Haybar, Narjes Sadat Sadati, Daryush Purrahman, Mohammad Reza Mahmoudian-Sani, Najmaldin Saki
Epigenomics.2023; 15(23): 1273. CrossRef

Others
Influence of Maternal Diabetes on the Risk of Neurodevelopmental Disorders in Offspring in the Prenatal and Postnatal Periods: Verónica Perea, Xavier Urquizu, Maite Valverde, Marina Macias, Anna Carmona, Esther Esteve, Gemma Escribano, Nuria Pons, Oriol Giménez, Teresa Gironés, Andreu Simó-Servat, Andrea Domenech, Núria Alonso-Carril, Carme Quirós, Antonio J. Amor, Eva López, Maria José Barahona; Diabetes Metab J. 2022;46(6):912-922. Published online April 29, 2022; DOI: https://doi.org/10.4093/dmj.2021.0340

8,036 View
305 Download
14 Web of Science
13 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
This study aimed to evaluate the influence of maternal diabetes in the risk of neurodevelopmental disorders in offspring in the prenatal and postnatal periods.
Methods
This cohort study included singleton gestational diabetes mellitus (GDM) pregnancies >22 weeks’ gestation with live newborns between 1991 and 2008. The control group was randomly selected and matched (1:2) for maternal age, weeks of gestation and birth year. Cox regression models estimated the effect of GDM on the risk of attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and maternal type 2 diabetes mellitus (T2DM). Moreover, interaction between maternal T2DM and GDM-ADHD relationship was evaluated.
Results
Children (n=3,123) were included (1,073 GDM; 2,050 control group). The median follow-up was 18.2 years (interquartile range, 14.2 to 22.3) (n=323 with ADHD, n=36 with ASD, and n=275 from women who developed T2DM). GDM exposure was associated with ADHD (hazard ratio [HR]_crude, 1.67; 95% confidence interval [CI], 1.33 to 2.07) (HR_adjusted, 1.64; 95% CI, 1.31 to 2.05). This association remained significant regardless of the treatment (diet or insulin) and diagnosis after 26 weeks of gestation. Children of mothers who developed T2DM presented higher rates of ADHD (14.2 vs. 10%, P=0.029). However, no interaction was found when T2DM was included in the GDM and ADHD models (P>0.05). GDM was not associated with an increased risk of ASD (HR_adjusted, 1.46; 95% CI, 0.74 to 2.84).
Conclusion
Prenatal exposure to GDM increases the risk of ADHD in offspring, regardless of GDM treatment complexity. However, postnatal exposure to maternal T2DM was not related to the development of ADHD.

Citations

Citations to this article as recorded by

Maternal diabetes during pregnancy and offspring's risk of autism spectrum disorder: A systematic review and meta-analysis
Mayra J. Garza-Martínez, José Á. Hernández-Mariano, Erika M. Hurtado-Salgado, Lea A. Cupul-Uicab
Journal of Psychiatric Research.2025; 182: 100. CrossRef
The association between maternal diabetes and the risk of attention deficit hyperactivity disorder in offspring: an updated systematic review and meta-analysis
Yitayish Damtie, Berihun Assefa Dachew, Getinet Ayano, Abay Woday Tadesse, Kim Betts, Rosa Alati
European Child & Adolescent Psychiatry.2025;[Epub] CrossRef
Research Progress on Short-Term and Long-Term Complications of Infants of Diabetic Mothers
桂婷冯
Advances in Clinical Medicine.2025; 15(03): 716. CrossRef
Gut–Brain Inflammatory Pathways in Attention-Deficit/Hyperactivity Disorder: The Role and Therapeutic Potential of Diet
Naomi Lewis, Jim Lagopoulos, Anthony Villani
Metabolites.2025; 15(5): 335. CrossRef
The association between maternal diabetes, antidiabetic medication use, and severe ADHD requiring inpatient care: A registry-based cohort study
Yitayish Damtie, Kim Betts, Berihun Assefa Dachew, Getinet Ayano, Rosa Alati
Journal of Psychosomatic Research.2025; 195: 112167. CrossRef
Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells
Vishal Chavda, Dhananjay Yadav, Snehal Patel, Minseok Song
Brain Sciences.2024; 14(3): 284. CrossRef
Understanding the link between different types of maternal diabetes and the onset of autism spectrum disorders
Wenyu Shao, Yichun Su, Jiayin Liu, Yulong Liu, Jinghui Zhao, Xiaotang Fan
Diabetes & Metabolism.2024; 50(4): 101543. CrossRef
Tracing the influence of prenatal risk factors on the offspring retina: Focus on development and putative long‐term consequences
Filipa I. Baptista, António F. Ambrósio
European Journal of Clinical Investigation.2024;[Epub] CrossRef
Risk cycling in diabetes and autism spectrum disorder: a bidirectional Mendelian randomization study
Yunfeng Yu, Xinyu Yang, Gang Hu, Keke Tong, Jingyi Wu, Rong Yu
Frontiers in Endocrinology.2024;[Epub] CrossRef
Maternal Diabetes Deregulates the Expression of Mecp2 via miR-26b-5p in Mouse Embryonic Neural Stem Cells
Sukanya Shyamasundar, Seshadri Ramya, Deepika Kandilya, Dinesh Kumar Srinivasan, Boon Huat Bay, Suraiya Anjum Ansari, S Thameem Dheen
Cells.2023; 12(11): 1516. CrossRef
Evaluating the prospects of using gestational diabetes mellitus model to find means of pharmacological correction of the disorders in rat offspring
A. S. Solomina, A. V. Rodina, K. S. Kachalov, A. D. Zakharov, A. D. Durnev
Pharmacokinetics and Pharmacodynamics.2023; (2): 45. CrossRef
Hair and cord blood element levels and their relationship with air pollution, dietary intake, gestational diabetes mellitus, and infant neurodevelopment
Yin-Yin Xia, Jamie V. de Seymour, Xiao-Jia Yang, Lin-Wei Zhou, Yue Liu, Yang Yang, Kathryn L. Beck, Cathryn A. Conlon, Toby Mansell, Boris Novakovic, Richard Saffery, Ting-Li Han, Hua Zhang, Philip N. Baker
Clinical Nutrition.2023; 42(10): 1875. CrossRef
Role of Excessive Weight Gain During Gestation in the Risk of ADHD in Offspring of Women With Gestational Diabetes
Verónica Perea, Andreu Simó-Servat, Carmen Quirós, Nuria Alonso-Carril, Maite Valverde, Xavier Urquizu, Antonio J Amor, Eva López, Maria-José Barahona
The Journal of Clinical Endocrinology & Metabolism.2022; 107(10): e4203. CrossRef

Metabolic Risk/Epidemiology
Higher Muscle Mass Protects Women with Gestational Diabetes Mellitus from Progression to Type 2 Diabetes Mellitus: Yujin Shin, Joon Ho Moon, Tae Jung Oh, Chang Ho Ahn, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang; Diabetes Metab J. 2022;46(6):890-900. Published online April 28, 2022; DOI: https://doi.org/10.4093/dmj.2021.0334

7,029 View
259 Download
4 Web of Science
6 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
We evaluated whether postpartum muscle mass affects the risk of type 2 diabetes mellitus (T2DM) in Korean women with gestational diabetes mellitus (GDM).
Methods
A total of 305 women with GDM (mean age, 34.9 years) was prospectively evaluated for incident prediabetes and T2DM from 2 months after delivery and annually thereafter. Appendicular skeletal muscle mass (ASM) was assessed with bioelectrical impedance analysis at the initial postpartum visit, and ASM, either divided by body mass index (BMI) or squared height, and the absolute ASM were used as muscle mass indices. The risk of incident prediabetes and T2DM was assessed according to tertiles of these indices using a logistic regression model.
Results
After a mean follow-up duration of 3.3 years, the highest ASM/BMI tertile group had a 61% lower risk of incident prediabetes and T2DM compared to the lowest tertile group, and this remained significant after we adjusted for covariates (adjusted odds ratio, 0.37; 95% confidence interval [CI], 0.15 to 0.92; P=0.032). Equivalent findings were observed in normal weight women (BMI <23 kg/m²), but this association was not significant for overweight women (BMI ≥23 kg/m²). Absolute ASM or ASM/height² was not associated with the risk of postpartum T2DM.
Conclusion
A higher muscle mass, as defined by the ASM/BMI index, was associated with a lower risk of postpartum prediabetes and T2DM in Korean women with GDM.

Citations

Citations to this article as recorded by

Gestational Diabetes Mellitus: Mechanisms Underlying Maternal and Fetal Complications
Jooyeop Lee, Na Keum Lee, Joon Ho Moon
Endocrinology and Metabolism.2025; 40(1): 10. CrossRef
Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women
Tomoki Kawahara, Nobutoshi Nawa, Keiko Murakami, Toshihiro Tanaka, Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Masatsugu Orui, Aoi Noda, Genki Shinoda, Yuki Nagata, Satoshi Nagaie, Soichi Ogishima, Junichi Sugawara, Shigeo Ku
Journal of Human Genetics.2025; 70(5): 265. CrossRef
Low muscle mass index is associated with type 2 diabetes risk in a Latin-American population: a cross-sectional study
Rosario Suárez, Celina Andrade, Estefania Bautista-Valarezo, Yoredy Sarmiento-Andrade, Andri Matos, Oliver Jimenez, Martha Montalvan, Sebastián Chapela
Frontiers in Nutrition.2024;[Epub] CrossRef
More appendicular lean mass relative to body mass index is associated with lower incident diabetes in middle-aged adults in the CARDIA study
Melanie S. Haines, Aaron Leong, Bianca C. Porneala, Victor W. Zhong, Cora E. Lewis, Pamela J. Schreiner, Karen K. Miller, James B. Meigs, Mercedes R. Carnethon
Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(1): 105. CrossRef
The Association of the Triglyceride and Muscle to Fat Ratio During Early Pregnancy with the Development of Gestational Diabetes Mellitus
Fang Wang, Yuan-Yuan Bao, Kang Yu
Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 3187. CrossRef
Correlation of body composition in early pregnancy on gestational diabetes mellitus under different body weights before pregnancy
Li Xintong, Xu Dongmei, Zhang Li, Cao Ruimin, Hao Yide, Cui Lingling, Chen Tingting, Guo Yingying, Li Jiaxin
Frontiers in Endocrinology.2022;[Epub] CrossRef

Metabolic Risk/Epidemiology
Effect of Different Types of Diagnostic Criteria for Gestational Diabetes Mellitus on Adverse Neonatal Outcomes: A Systematic Review, Meta-Analysis, and Meta-Regression: Fahimeh Ramezani Tehrani, Marzieh Saei Ghare Naz, Razieh Bidhendi-Yarandi, Samira Behboudi-Gandevani; Diabetes Metab J. 2022;46(4):605-619. Published online March 8, 2022; DOI: https://doi.org/10.4093/dmj.2021.0178

8,394 View
337 Download
17 Web of Science
16 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Evidence supporting various diagnostic criteria for diagnose gestational diabetes mellitus (GDM) are consensus-based, needs for additional evidence related to outcomes. Therefore, the aim of this systematic-review and meta-analysis was to assess the impact of different GDM diagnostic-criteria on the risk of adverse-neonatal-outcomes.
Methods
Electronic databases including Scopus, PubMed, and Web of Sciences were searched to retrieve English original, population-based studies with the universal GDM screening approach, up to January-2020. GDM diagnostic criteria were classified in seven groups and International Association of the Diabetes and Pregnancy Study Groups (IADPSG) was considered as reference one. We used the Mantel–Haenszel method to calculate the pooled odds of events. The possibility of publication bias was examined by Begg’s test.
Results
A total of 55 population-based studies consisting of 1,604,391 pregnant women with GDM and 7,770,855 non-GDM counterparts were included. Results showed that in all diagnostic-criteria subgroups, the risk of adverse neonatal outcomes including macrosomia, hyperbilirubinemia, respiratory distress syndrome, neonatal hypoglycemia, neonatal intensive care unit admission, preterm birth, and birth-trauma were significantly higher than the non-GDM counterparts were significantly higher than non-GDM counterparts. Meta-regression analysis revealed that the magnitude of neonatal risks in all diagnostic-criteria subgroups are similar.
Conclusion
Our results showed that the risk of adverse-neonatal-outcome increased among women with GDM, but the magnitude of risk was not different among those women who were diagnosed through more or less intensive strategies. These findings may help health-care-providers and policy-makers to select the most cost-effective approach for the screening of GDM among pregnant women.

Citations

Citations to this article as recorded by

Blood Cells Parameters in Second Trimester of Pregnancy and Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis
Vida Ghasemi, Mojdeh Banaei, Zahra Kiani, Fahimeh Ramezani Tehrani, Marzieh Saei Ghare Naz
Endocrinology, Diabetes & Metabolism.2025;[Epub] CrossRef
Trajectories of Maternal Urinary Iodine Concentration Are Associated With Gestational Diabetes Mellitus
Yahui Li, Simeng Gu, Zhe Mo, Xueqing Li, Yujie Jiang, Chenyang Liu, Fanjia Guo, Guangming Mao, Yuanyang Wang, Xuemin Huang, Hong Li, Zhijian Chen, Xiaofeng Wang, Xiaoming Lou
Clinical Endocrinology.2025; 102(5): 517. CrossRef
First Trimester Hematological Indices in Gestational Diabetes Mellitus: A Meta-Analysis
Faegheh Firouzi, Fahimeh Ramezani Tehrani, Hojat Shaharki, Maryam Mousavi, Nahid Moradi, Marzieh Saei Ghare Naz
Journal of the Endocrine Society.2025;[Epub] CrossRef
Pregnancy and postpartum cardiometabolic outcomes among women with overt diabetes compared to women with normoglycaemia, gestational diabetes and pre‐existing diabetes: A systematic review and meta‐analysis
Adarsh Pal, Dimple Rawat, Sankeerth Sadananda, Alpesh Goyal, Partha Haldar, Deepali Garg, Yashdeep Gupta, Nikhil Tandon
Diabetes, Obesity and Metabolism.2025;[Epub] CrossRef
Factors influencing healthy dietary behavior changes among patients with gestational diabetes mellitus during pregnancy: A meta‐synthesis using the theoretical domains framework
Qianqian Li, Yueshuai Pan, Yi Li, Ruting Gu, Jingyuan Wang, Yan Zhang, Xinwei Zhang, Yuan Zhu, Lili Wei
Journal of Obstetrics and Gynaecology Research.2025;[Epub] CrossRef
Hyperglycemia in pregnancy did not worsen the short-term outcomes of very preterm infants: a propensity score matching study
Ying Li, Wei Shen, Rong Zhang, Jian Mao, Ling Liu, Yan-Mei Chang, Xiu-Zhen Ye, Yin-Ping Qiu, Li Ma, Rui Cheng, Hui Wu, Dong-Mei Chen, Ling Chen, Ping Xu, Hua Mei, San-Nan Wang, Fa-Lin Xu, Rong Ju, Xiao-Mei Tong, Xin-Zhu Lin, Fan Wu
Frontiers in Pediatrics.2024;[Epub] CrossRef
One-step vs 2-step gestational diabetes mellitus screening and pregnancy outcomes: an updated systematic review and meta-analysis
Cintia Gomes, Itamar D. Futterman, Olivia Sher, Bracha Gluck, Teresa A. Hillier, Fahimeh Ramezani Tehrani, Nadim Chaarani, Nelli Fisher, Vincenzo Berghella, Rodney A. McLaren
American Journal of Obstetrics & Gynecology MFM.2024; 6(5): 101346. CrossRef
2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of the Korean Diabetes Association
Jun Sung Moon, Shinae Kang, Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, Yoon Ju Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang
Diabetes & Metabolism Journal.2024; 48(4): 546. CrossRef
Cardiovascular risk factors in Moroccan women: systematic review and meta-analysis
Es-sabir Fatima, Lahlou Laila, Afaf Bouqoufi, Lahoucine Amsdar, Majdouline Obtel
BMC Public Health.2024;[Epub] CrossRef
Association between gestational diabetes mellitus diagnostic criteria and adverse pregnancy outcomes—a systematic review and meta-analysis of adjusted effect sizes from studies using current diagnostic criteria
Elhassan Mahmoud, Abdalla Moustafa Elsayed, Basant Elsayed, Yasmin Elsalakawi, Aswathy Gopinath, Tawanda Chivese
BMJ Open.2024; 14(11): e091258. CrossRef
Diabetesscreening in der Schwangerschaft
Ute Schäfer-Graf
Die Gynäkologie.2023; 56(2): 103. CrossRef
One-step versus two-step screening for diagnosis of gestational diabetes mellitus in Iranian population: A randomized community trial
Fahimeh Ramezani Tehrani, Maryam Rahmati, Farshad Farzadfar, Mehrandokht Abedini, Maryam Farahmand, Farhad Hosseinpanah, Farzad Hadaegh, Farahnaz Torkestani, Majid Valizadeh, Fereidoun Azizi, Samira Behboudi-Gandevani
Frontiers in Endocrinology.2023;[Epub] CrossRef
Predictors of Neonatal Intensive Care Unit Admission and Adverse Outcomes Related to Gestational Diabetes
Abdullah M Al-shahrani
Cureus.2023;[Epub] CrossRef
Positive association between circulating Caveolin-1 and microalbuminuria in overt diabetes mellitus in pregnancy
Y. Shu, Y. Xiong, Y. Song, S. Jin, X. Bai
Journal of Endocrinological Investigation.2023; 47(1): 201. CrossRef
Early-to-mid pregnancy sleep and circadian markers in relation to birth outcomes: An epigenetics pilot study
Erica C. Jansen, Kelvin Pengyuan Zhang, Dana C. Dolinoy, Helen J. Burgess, Louise M. O’Brien, Elizabeth Langen, Naquia Unwala, Jessa Ehlinger, Molly C. Mulcahy, Jaclyn M. Goodrich
Chronobiology International.2023; 40(9): 1224. CrossRef
Various screening and diagnosis approaches for gestational diabetes mellitus and adverse pregnancy outcomes: a secondary analysis of a randomized non-inferiority field trial
Fahimeh Ramezani Tehrani, Ali Sheidaei, Maryam Rahmati, Farshad Farzadfar, Mahsa Noroozzadeh, Farhad Hosseinpanah, Mehrandokht Abedini, Farzad Hadaegh, Majid Valizadeh, Farahnaz Torkestani, Davood Khalili, Faegheh Firouzi, Masoud Solaymani-Dodaran, Afshin
BMJ Open Diabetes Research & Care.2023; 11(6): e003510. CrossRef

Review

Metabolic Risk/Epidemiology
Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications: Joon Ho Moon, Hak Chul Jang; Diabetes Metab J. 2022;46(1):3-14. Published online January 27, 2022; DOI: https://doi.org/10.4093/dmj.2021.0335

31,175 View
1,425 Download
160 Web of Science
164 Crossref

Graphical Abstract Abstract PDF PubReader ePub

Gestational diabetes mellitus (GDM) is the most common complication during pregnancy and is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. GDM is associated with adverse pregnancy outcomes and long-term offspring and maternal complications. For GDM screening and diagnosis, a two-step approach (1-hour 50 g glucose challenge test followed by 3-hour 100 g oral glucose tolerance test) has been widely used. After the Hyperglycemia and Adverse Pregnancy Outcome study implemented a 75 g oral glucose tolerance test in all pregnant women, a one-step approach was recommended as an option for the diagnosis of GDM after 2010. The one-step approach has more than doubled the incidence of GDM, but its clinical benefit in reducing adverse pregnancy outcomes remains controversial. Long-term complications of mothers with GDM include type 2 diabetes mellitus and cardiovascular disease, and complications of their offspring include childhood obesity and glucose intolerance. The diagnostic criteria of GDM should properly classify women at risk for adverse pregnancy outcomes and long-term complications. The present review summarizes the strengths and weaknesses of the one-step and two-step approaches for the diagnosis of GDM based on recent randomized controlled trials and observational studies. We also describe the long-term maternal and offspring complications of GDM.

Citations

Citations to this article as recorded by

Beyond one size fits all: Probing patient choices in gestational diabetes management, from screening to postpartum
Ayman Mobin, Amir Obeid, Imad El‐Kebbi, Dean Everett, Saleh Ibrahim, Joviana Farhat, Basem Al‐Omari
Chronic Diseases and Translational Medicine.2025; 11(1): 33. CrossRef
Associations of systemic immune-inflammation index and systemic inflammation response index with maternal gestational diabetes mellitus: Evidence from a prospective birth cohort study
Shuanghua Xie, Enjie Zhang, Shen Gao, Shaofei Su, Jianhui Liu, Yue Zhang, Yingyi Luan, Kaikun Huang, Minhui Hu, Xueran Wang, Hao Xing, Ruixia Liu, Wentao Yue, Chenghong Yin
Chinese Medical Journal.2025; 138(6): 729. CrossRef
Quality of Life in Women With Gestational Diabetes Mellitus and Treatment Satisfaction Upon Intermittently Scanned Continuous Glucose Monitoring
Sookyung Won, Hyeon Ji Kim, Jee Yoon Park, Kyung Joon Oh, Sung Hee Choi, Hak Chul Jang, Joon Ho Moon
Journal of Korean Medical Science.2025;[Epub] CrossRef
Gestational diabetes mellitus-derived miR-7-19488 targets PIK3R2 mRNA to stimulate the abnormal development and maturation of offspring-islets
Chunxue Xu, Linhai Zou, Li Wang, Wenshan Lv, Xiangju Cao, Xinyu Jia, Yuan Wang, Guohui Jiang, Lixia Ji
Life Sciences.2025; 363: 123369. CrossRef
How Do Maternal Gestational Diabetes and Other Concomitant Maternal Factors Determine the Perinatal Outcomes of Pregnancy?—A Retrospective Analysis
Karolina Karcz, Barbara Królak-Olejnik
Nutrients.2025; 17(1): 177. CrossRef
Blood Cells Parameters in Second Trimester of Pregnancy and Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis
Vida Ghasemi, Mojdeh Banaei, Zahra Kiani, Fahimeh Ramezani Tehrani, Marzieh Saei Ghare Naz
Endocrinology, Diabetes & Metabolism.2025;[Epub] CrossRef
Gut microbiome-derived metabolites and their impact on gene regulatory networks in gestational diabetes
Sarvesh Sabarathinam, Akash Jayaraman, Ramesh Venkatachalapathy
The Journal of Steroid Biochemistry and Molecular Biology.2025; 247: 106674. CrossRef
Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study
Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Yuichiro Miura, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima
Journal of Diabetes Investigation.2025; 16(4): 735. CrossRef
Targeted metabolomics reveals novel biomarkers for gestational diabetes mellitus
Zhuangfei Xu, Jiali Fang, Yi Wang, Xiaoting Wu, Lan Liu, Xianwei Cui, Hong Zhong, Tianying Zhong
Diabetes, Obesity and Metabolism.2025; 27(4): 2163. CrossRef
Risk of neonatal SARS-CoV-2 infection: a retrospective cohort study based on infected mothers with gestational diabetes mellitus
Jing Ni, Yongfei Zheng, Jiaqi Tian, Lin Zhang, Shuyin Duan
Frontiers in Endocrinology.2025;[Epub] CrossRef
Retrospective Analysis of the Correlation between Umbilical Blood Flow Index and Maternal and Fetal Outcomes in Pregnant Women with Gestational Diabetes
Qiong Liu, Sinan Shu, Xiuping Zhao, Huiling Yu
British Journal of Hospital Medicine.2025; 86(1): 1. CrossRef
A Review of the Impact of Gestational Diabetes on Fetal Brain Development: An Update on Neurosonographic Markers During the Last Decade
Efthymios Oikonomou, Christos Chatzakis, Sofoklis Stavros, Anastasios Potiris, Konstantinos Nikolettos, Sotirios Sotiriou, Ekaterini Domali, Nikolaos Nikolettos, Alexandros Sotiriadis, Angeliki Gerede
Life.2025; 15(2): 210. CrossRef
Mothers with obesity and gestational diabetes did not induce brain pathologies or premature brain aging in their adolescent and early adult offspring in rats
Huatuo Huang, Nattayaporn Apaijai, Chanisa Thonusin, Panan Suntornsaratoon, Nipon Chattipakorn, Narattaphol Charoenphandhu, Siriporn C. Chattipakorn
Neuroscience.2025; 568: 454. CrossRef
Integration of transcriptomics and metabolomics data revealed role of insulin resistant SNW1 gene in the pathophysiology of gestational diabetes
Ravi Bhushan, Rimjhim Trivedi, Ritu Raj, Anjali Rani, Sangeeta Rai, Anima Tripathi, Shiv Govind Rawat, Ajay Kumar, Dinesh Kumar, Pawan K. Dubey
Scientific Reports.2025;[Epub] CrossRef
Efficacy and safety of pharmacological treatments for gestational diabetes: a systematic review comparing metformin with glibenclamide and insulin
Louise Bodier, Maela Le Lous, Hélène Isly, Christèle Derrien, Patricia Vaduva
Diabetes & Metabolism.2025; 51(2): 101622. CrossRef
Animal Models for Studying Developmental Origins of Cardiovascular–Kidney–Metabolic Syndrome
You-Lin Tain, Ying-Jui Lin, Chien-Ning Hsu
Biomedicines.2025; 13(2): 452. CrossRef
Investigation of Adhesion Molecules in the Placentas of Patients with Gestational Diabetes Mellitus with Premature Rupture of Membranes
Muhyiddin Sancar , Esranur Atiç , Mehmet Uğur Karabat , Şehmus Kaplan , Ayfer Aktaş , Fırat Aşır
Journal of Drug Delivery and Therapeutics.2025; 15(2): 45. CrossRef
Association of serum inflammatory markers in early-pregnancy with the risk for gestational diabetes mellitus: a prospective cohort in Shenzhen, China
Yijin Wang, Qinqin Ren, Hui Yuan, Yang Wang, Yao Liu, Yuanhuan Wei, Ruifang Sun, Hongguang Yang, Ping Tian, Jianjun Yang, Guifang Deng
Frontiers in Endocrinology.2025;[Epub] CrossRef
Gestational Diabetes Mellitus: Mechanisms Underlying Maternal and Fetal Complications
Jooyeop Lee, Na Keum Lee, Joon Ho Moon
Endocrinology and Metabolism.2025; 40(1): 10. CrossRef
Bridging gaps in artificial intelligence adoption for maternal-fetal and obstetric care: Unveiling transformative capabilities and challenges
Kalyan Tadepalli, Abhijit Das, Tanushree Meena, Sudipta Roy
Computer Methods and Programs in Biomedicine.2025; 263: 108682. CrossRef
Comparison of 75g OGTT and Four Sugar Profiles in Diagnosis of Gestational Diabetes Mellitus
Yamina Ishtiaq, Shazia Fakhar, Hina Gul, Darakhshan Sheikh
Indus Journal of Bioscience Research.2025; 3(3): 99. CrossRef
The Hidden Impact of Gestational Diabetes: Unveiling Offspring Complications and Long-Term Effects
Elsa Al Bekai, Carla El Beaini, Karim Kalout, Ouhaila Safieddine, Sandra Semaan, François Sahyoun, Hilda E. Ghadieh, Sami Azar, Amjad Kanaan, Frederic Harb
Life.2025; 15(3): 440. CrossRef
Unveiling Gestational Diabetes: An Overview of Pathophysiology and Management
Rahul Mittal, Karan Prasad, Joana R. N. Lemos, Giuliana Arevalo, Khemraj Hirani
International Journal of Molecular Sciences.2025; 26(5): 2320. CrossRef
Impact of fructooligosaccharides on gut microbiota and microbial metabolites in gestational diabetes mellitus: An in vitro fermentation model study
Zhi Du, Yang Bi, Jiabin Li, Zhiwei Xu, Jieying Ding, Mengshan Huang, Meng Zhang, Daqing Ma, Hui Wang, Zhigang Liu, Jing Miao
Journal of Functional Foods.2025; 127: 106740. CrossRef
Predictive Value of First‐Trimester Aggregate Index of Systemic Inflammation (AISI) and Other Inflammatory Indices for Gestational Diabetes Mellitus and Associated Obstetric Outcomes
Esra Karatas, Atakan Tanacan, Osman Onur Ozkavak, Burcu Bozkurt Ozdal, Hatice Betul Ucar, Ozgur Kara, Dilek Sahin
American Journal of Reproductive Immunology.2025;[Epub] CrossRef
Increased First Trimester Serum Uric Acid as A Predictor of Gestational Diabetes Mellitus
Muhammad Faisal Javaid, . Azra, Sadiq Jan, Fauzia Sadiq, Tehmeena Munawar, Naveeda Nawaz
Pakistan Journal of Health Sciences.2025; : 121. CrossRef
Does Fetal Size Affect Umbilical Artery Pulsatility Index in Pregnancies Complicated by Gestational Diabetes?
Libera Troìa, Alessandro Libretti, Stefania Ferrari, Anna Dotta, Sonia Giacomini, Erika Mainolfi, Federica Spissu, Alessia Tivano, Daniela Surico, Valentino Remorgida
Diabetology.2025; 6(4): 27. CrossRef
The impact of environmental and dietary exposure on gestational diabetes mellitus: a comprehensive review emphasizing the role of oxidative stress
Congcong Sun, Jiaying Shen, Rujing Fang, Huiya Huang, Yanan Lai, Yanjun Hu, Jianqiong Zheng
Frontiers in Endocrinology.2025;[Epub] CrossRef
Association of gestational diabetes mellitus diagnosed at different time points in oral glucose tolerance test with adverse pregnancy outcomes: a retrospective cohort study
Ruipeng Lin, Yulong Zhang, Yuxin Lin, Lili Yang, Jiayi Chen, Qingxiu Li, Haibo Li, Qian Zhang
Frontiers in Endocrinology.2025;[Epub] CrossRef
Metabolic Phenotypes of Women with Gestational Diabetes Mellitus Affect the Risk of Adverse Pregnancy Outcomes
Joon Ho Moon, Sookyung Won, Hojeong Won, Heejun Son, Tae Jung Oh, Soo Heon Kwak, Sung Hee Choi, Hak Chul Jang
Endocrinology and Metabolism.2025; 40(2): 247. CrossRef
Pilot Study of Growth Factors in Colostrum: How Delivery Mode and Maternal Health Impact IGF-1, EGF, NGF, and TGF-β Levels in Polish Women
Paweł Paśko, Jadwiga Kryczyk-Kozioł, Paweł Zagrodzki, Ewelina Prochownik, Martyna Ziomek, Ryszard Lauterbach, Hubert Huras, Magdalena Staśkiewicz, Justyna Dobrowolska-Iwanek
Nutrients.2025; 17(8): 1386. CrossRef
Human umbilical cord mesenchymal stem cell-derived exosomal miR-455-3p targets CAMK2N1 to improve trophoblast cell injury in gestational diabetes mellitus
Yan Zhang, Mingyu Du, Baosheng Zhu, Runmei Ma, Jinman Zhang
Diabetology & Metabolic Syndrome.2025;[Epub] CrossRef
Advancing Early Prediction of Gestational Diabetes Mellitus with Circular RNA Biomarkers
Joon Ho Moon, Sung Hee Choi
Diabetes & Metabolism Journal.2025; 49(3): 403. CrossRef
The influence of socioeconomic status on the association between residential greenness and gestational diabetes mellitus in an urban setting: a multicenter study
Tian Zhang, Wen Jiang, Yun Huang, Cuiping Wang, Jun Cao, Wei Qiu, Rong Huang, Jun Zhang, Weiping Ye, Qingli Zhang
BMC Public Health.2025;[Epub] CrossRef
Mediating effect of osteocalcin underlying the link between insulin-like growth factor-I and gestational diabetes mellitus
Lingling Cui, Yuting Gao, Ruijie Sun, Zhiqian Li, Zhengya Zhang, Linpu Ji, Yibo Wang, Hua Ye, Luying Qin
BMC Pregnancy and Childbirth.2025;[Epub] CrossRef
Influence of gestational diabetes mellitus on the cardiovascular system and its underlying mechanisms
Ze Zhang, Yumeng Zhang, Shuai Huang, Min Li, Lingjun Li, Linglu Qi, Yun He, Zhice Xu, Jiaqi Tang
Frontiers in Endocrinology.2025;[Epub] CrossRef
Association of maternal thyroid function and gestational diabetes with pregnancy outcomes: a retrospective cohort study
Chang Zou, Qinxin Shen, Yuanyuan Yang, Yini Liao, Qiaoling Du
Frontiers in Endocrinology.2025;[Epub] CrossRef
Transplacental transfer of metformin and interaction of metformin with the uptake transporters of placental trophoblast cells
Xiaoting Gu, Yutian Cai, Chaoyue Zheng, Keran Li, Shuwen Zhu, Shaohan Zhang, Ziqi Wang, Jianxiong Xiang, Zhipeng Cheng, Xiaoyu Ai, Cheng Yang
European Journal of Pharmaceutical Sciences.2025; : 107161. CrossRef
Expression and clinical significance of mir-520g-3p in patients with gestational diabetes mellitus
Yi Ding, Min Cai, Yan Wang, Runpeng Zhao, Xin Yue
Journal of Diabetes & Metabolic Disorders.2025;[Epub] CrossRef
Prophylactic administration of metformin reduces gestational diabetes mellitus incidence in the high-risk populations: a meta-analysis
Hui Yu, Jinling Sun, Honglei Hu
Irish Journal of Medical Science (1971 -).2024; 193(1): 199. CrossRef
Association of dietary inflammatory index with risk of gestational diabetes mellitus and preeclampsia: a systematic review and meta-analysis
Li Hong, Liyuan Zhu, Jinru Zhang, Yueqi Fu, Xiaoyan Qi, Mei Zhao
British Journal of Nutrition.2024; 131(1): 54. CrossRef
Ferritin and iron supplements in gestational diabetes mellitus: less or more?
Tianlian Li, Jingfan Zhang, Ping Li
European Journal of Nutrition.2024; 63(1): 67. CrossRef
Comparing the screening methods for gestational diabetes mellitus before and during the COVID‐19 pandemic: A systematic review
Xingge Sun, Clare McKeaveney, Helen Noble, Hannah O’Hara, Oliver Perra
Journal of Diabetes Investigation.2024; 15(4): 500. CrossRef
Protective Effects of Paeoniflorin Against Inflammation and Oxidative Stress in Rats with Gestational Diabetes Mellitus via Inhibiting the RhoA/ROCK Signaling Pathway
Cheng kun Yuan, Yan Gao, Jinglu Yu, Limin Peng
Revista Brasileira de Farmacognosia.2024; 34(3): 536. CrossRef
METTL14‐mediated lncRNA XIST silencing alleviates GDM progression by facilitating trophoblast cell proliferation and migration via the miR‐497‐5p/FOXO1 axis
Yanchuan Li, Yanfeng Liu, Xiao Yao, Haili Wang, Ziyun Shi, Meiqing He
Journal of Biochemical and Molecular Toxicology.2024;[Epub] CrossRef
Evaluation of insulin secretion and insulin sensitivity in pregnant women: Application value of simple indices
Shuying Ren, Dan Wu, Ping Li
Clinica Chimica Acta.2024; 554: 117753. CrossRef
ATP5me alleviates high glucose-induced myocardial cell injury
Qingsha Hou, Fang Yan, Xiuling Li, Huanling Liu, Xiang Yang, Xudong Dong
International Immunopharmacology.2024; 129: 111626. CrossRef
Aberrant NK cell profile in gestational diabetes mellitus with fetal growth restriction
Yujing Xiong, Yazhen Wang, Mengqi Wu, Shuqiang Chen, Hui Lei, Hui Mu, Haikun Yu, Yongli Hou, Kang Tang, Xutao Chen, Jie Dong, Xiaohong Wang, Lihua Chen
Frontiers in Immunology.2024;[Epub] CrossRef
Maternal Diabetes and Risk of Hypospadias: A Systemic Review and Meta-Analysis
Zhiyuan Liu, Chengjun Yu, Shuhan Yang, Jin Luo, Jie Zhang, Xiao Wang, Chun Wei, Qinlin Shi, Yi Hua, Xing Liu, Guanghui Wei
Urologia Internationalis.2024; 108(2): 108. CrossRef
Maternal birth weight as an indicator of early and late gestational diabetes mellitus: The Japan Environment and Children's Study
Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima
Journal of Diabetes Investigation.2024; 15(6): 751. CrossRef
Perinatal characteristics and pregnancy outcomes of advanced maternal age women with gestational diabetes mellitus: A retrospective cohort study
Chen Jiang, Haiyan Wen, Tingting Hu, Yanfei Liu, Xiaoqing Dai, Yiming Chen
Health Science Reports.2024;[Epub] CrossRef
Phenotypic characterisation of regulatory T cells in patients with gestational diabetes mellitus
Ya-nan Zhang, Qin Wu, Yi-hui Deng
Scientific Reports.2024;[Epub] CrossRef
Healthy behaviors and gestational diabetes mellitus in an Iranian setting: A cross-sectional study
Maryam Zare, Afrouz Mardi, Paria Yeghanenia, Daniel Hackett
Medicine.2024; 103(9): e36431. CrossRef
Post‐load glucose is a stronger predictor of adverse pregnancy outcomes than first‐trimester HbA1c in women without gestational diabetes
Shahin Keshtkar Rajabi, Elham Toghraee, Golnoosh Nejatipour
Journal of Diabetes Investigation.2024; 15(7): 914. CrossRef
Triglyceride-glucose index in early pregnancy predicts the risk of gestational diabetes: a prospective cohort study
Yufeng Guo, Junwen Lu, Mailiman Bahani, Guifeng Ding, Lei Wang, Yuxia Zhang, Huanmei Zhang, Chengyao Liu, Lijun Zhou, Xiaolan Liu, Fangshen Li, Xiaoli Wang, Hong Ding
Lipids in Health and Disease.2024;[Epub] CrossRef
A study on behavior, diet patterns and physical activity among selected GDM and non-GDM women in south India
S Sindhu, S Uma Mageshwari
Journal of Diabetology.2024; 15(1): 86. CrossRef
The Implication of Diabetes-Specialized Nurses in Aiming for the Better Treatment and Management of Patients with Diabetes Mellitus: A Brief Narrative Review
Yefang Zhu, Hongmei Zhang, Ying Xi, Hongli Zhu, Yan Lu, Xue Luo, Zhangui Tang, Hong Lei
Diabetes Therapy.2024; 15(5): 917. CrossRef
Triglyceride-glucose index: A promising biomarker for predicting risks of adverse pregnancy outcomes in Hangzhou, China
Jinghua Zhang, Binbin Yin, Ya Xi, Yongying Bai
Preventive Medicine Reports.2024; 41: 102683. CrossRef
Associations of education attainment with gestational diabetes mellitus and the mediating effects of obesity: A Mendelian randomization study
Xiaoyan Wang, Ying Lan, Na Li, Jinfeng Gao, Dejiao Meng, Shuchuan Miao
Heliyon.2024; 10(7): e29000. CrossRef
Quality assessment of videos on social media platforms related to gestational diabetes mellitus in China: A cross-section study
Qin-Yu Cai, Jing Tang, Si-Zhe Meng, Yi Sun, Xia Lan, Tai-Hang Liu
Heliyon.2024; 10(7): e29020. CrossRef
One abnormal value in oral glucose tolerance test during pregnancy and type 2 diabetes risk: Insights from a 5-Year Follow-Up study
Rawia Hussein-Aro, Esther Maor-Sagie, Yoel Toledano, Mordechai Hallak, Rinat Gabbay-Benziv
Diabetes Research and Clinical Practice.2024; 211: 111659. CrossRef
Assessment of the Level of Knowledge About Risk Factors, Prevention, and Treatment of Gestational Diabetes Mellitus in a Community Sample From Saudi Arabia
Suzan A Morsy, Ayat M Tawfik, Samar Y Badayyan, Lameer K Shaikh, Shaden AzizKhan, AlKhansaa A Zakari
Cureus.2024;[Epub] CrossRef
Genetic Susceptibility, Mendelian Randomization, and Nomogram Model Construction of Gestational Diabetes Mellitus
Qiulian Liang, Ming Li, Gongchen Huang, Ruiqi Li, Linyuan Qin, Ping Zhong, Xuekun Xing, Xiangyuan Yu
The Journal of Clinical Endocrinology & Metabolism.2024; 109(11): 2802. CrossRef
Study on the regulation of trophoblast activity by abnormally expressed hsa_circ_0024838/miR-543/HIF1A in patients with gestational diabetes mellitus
Qian Liu, Juan Gui, Lianzhi Wu
Placenta.2024; 151: 27. CrossRef
Association between sleep duration during pregnancy and gestational diabetes mellitus: a systematic review and meta-analysis
Yuandong Li, Chao Liang, Cui Wu, Zheng Nan
Frontiers in Medicine.2024;[Epub] CrossRef
Ultrasonographic diagnosis of fetal hemodynamic parameters in pregnant women with diabetes mellitus in the third trimester of pregnancy
Dongmei Cai, Su Yan
Heliyon.2024; 10(11): e30352. CrossRef
Gestational diabetes mellitus and development of intergenerational non-alcoholic fatty liver disease (NAFLD) after delivery: a systematic review and meta-analysis
Ru Xun Foo, Jenny Junyi Ma, Ruochen Du, George Boon Bee Goh, Yap Seng Chong, Cuilin Zhang, Ling-Jun Li
eClinicalMedicine.2024; 72: 102609. CrossRef
Perceptions of Chinese women with a history of gestational diabetes regarding health behaviors and related factors: a directed qualitative content analysis
Xiaoxia Ma, Yun Yang, Shuhua Qian, Yan Ding, Qiping Lin, Na Wang
BMC Public Health.2024;[Epub] CrossRef
Associations of serum D-dimer and glycosylated hemoglobin levels with third-trimester fetal growth restriction in gestational diabetes mellitus
Ying Zhang, Teng Li, Chao-Yan Yue, Yun Liu
World Journal of Diabetes.2024; 15(5): 914. CrossRef
Characterizing the Dynamic Expression of C1q/TNF-α-Related Protein 6 (CTRP6) during Pregnancy in Humans and Mice with Gestational Diabetes Mellitus
Jianan Jiang, Shuangyu Wei, Miao Chen, Yutian Tan, Zhao Yang, Guiying Yang, Weijie Feng, Zhen Han, Xiaojing Wei, Xiao Luo
Biomedicines.2024; 12(5): 1128. CrossRef
Influence of mHealth-Based Lifestyle Interventions on Symptoms of Anxiety and Depression of Women With Gestational Diabetes: A Meta-Analysis
Rong Liao, Yamin Li, Hui Yang, Yaoyue Luo
Clinical Nursing Research.2024; 33(6): 448. CrossRef
Association of VDR gene variant rs2228570-FokI with gestational diabetes mellitus susceptibility in Arab women
Maysa Alzaim, Mohammed G.A. Ansari, Abeer A. Al-Masri, Malak N.K. Khattak, Abir Alamro, Amani Alghamdi, Amal Alenad, Majed Alokail, Omar S. Al-Attas, Ahmad G. Al-Zahrani, Nasser M. Al-Daghri
Heliyon.2024; 10(11): e32048. CrossRef
Placental Expression of Glucose and Zinc Transporters in Women with Gestational Diabetes
Łukasz Ustianowski, Michał Czerewaty, Kajetan Kiełbowski, Estera Bakinowska, Maciej Tarnowski, Krzysztof Safranow, Andrzej Pawlik
Journal of Clinical Medicine.2024; 13(12): 3500. CrossRef
Development and validation of gestational diabetes mellitus health literacy scale
Ruting Gu, Tong Sun, Yueshuai Pan, Jingyuan Wang, Qianqian Li, Yan Zhang, Yalin Tang, Haiqing Zhou, Lili Wei
Patient Education and Counseling.2024; 127: 108365. CrossRef
Efectele placentare ale rezistenţei la insulină în sarcinile complicate cu diabet zaharat gestaţional
Ionescu Gabriela, Marina Nicolae-Gabriel, Scurtu Francesca, Dorneanu Denisa, Edu Mihnea-Dan, Mateescu Radu-Nicolae, Mihaela Plotogea, Antoine Edu, Claudia Mehedinţu, Noditi Aniela
Obstetrica şi Ginecologia.2024; 2(73): 74. CrossRef
The problem of diabetes mellitus in obstetrics
E.V. Popova-Petrosyan, A.A. Dovgan’, E.R. Kulieva
Russian Bulletin of Obstetrician-Gynecologist.2024; 24(3): 25. CrossRef
Second‐trimester triglyceride‐glucose index to predict adverse outcomes in women with gestational diabetes mellitus: A retrospective multicenter cohort study
Xueqi Bai, Qingyi Zhu, Wenli Wang, Sutong Kan, Shiman Hu, Runrun Hao, Shanshan Wang, Zhonghua Shi
Journal of Diabetes Investigation.2024; 15(10): 1489. CrossRef
Therapeutic effect of Momordica charantia on cardiomyopathy in a diabetic maternal rat model
Shaimaa M. Elnahas, Hend Abd El‐Halim Mansour, Mamdouh R. El‐Sawi, Amoura M. Abou‐El‐Naga
Journal of Experimental Zoology Part A: Ecological and Integrative Physiology.2024; 341(9): 977. CrossRef
Functional genetic variants and susceptibility and prediction of gestational diabetes mellitus
Gongchen Huang, Yan Sun, Ruiqi Li, Lei Mo, Qiulian Liang, Xiangyuan Yu
Scientific Reports.2024;[Epub] CrossRef
Early Methylglyoxal Exposure Leads to Worsened Cardiovascular Function in Young Rats
Marcos Divino Ferreira-Junior, Keilah Valéria N. Cavalcante, Jaqueline M. Costa, Amanda S. M. Bessa, Andreia Amaro, Carlos Henrique de Castro, Carlos Henrique Xavier, Sónia Silva, Diogo A. Fonseca, Paulo Matafome, Rodrigo Mello Gomes
Nutrients.2024; 16(13): 2029. CrossRef
The prevalence of gestational diabetes among underweight and normal weight women worldwide: a scoping review
Emily S. Gitlin, Michelle Demetres, Arthi Vaidyanathan, Nicole Palmer, Hannah Lee, Sabrina Loureiro, Eman Radwan, Abigail Tuschman, Jyoti Mathad, Puja Chebrolu
Frontiers in Clinical Diabetes and Healthcare.2024;[Epub] CrossRef
Metformin administration during pregnancy tends to reduce the risk of gestational diabetes mellitus and improve pregnancy outcomes in previously infertile women with polycystic ovary syndrome who become pregnant
Huamei Liu, Yajia Liu, Changhe Wei, Shoujiu Zhang, Yanjie Xu
Irish Journal of Medical Science (1971 -).2024; 193(6): 2843. CrossRef
Longitudinal integrative cell-free DNA analysis in gestational diabetes mellitus
Zhuangyuan Tang, Shuo Wang, Xi Li, Chengbin Hu, Qiangrong Zhai, Jing Wang, Qingshi Ye, Jinnan Liu, Guohong Zhang, Yuanyuan Guo, Fengxia Su, Huikun Liu, Lingyao Guan, Chang Jiang, Jiayu Chen, Min Li, Fangyi Ren, Yu Zhang, Minjuan Huang, Lingguo Li, Haiqian
Cell Reports Medicine.2024; 5(8): 101660. CrossRef
Dual-mode detection of glucose based on pistol-like DNAzyme-mediated exonuclease-assisted signal cycle
Huiying Lu, Xiaofeng Wang
BioTechniques.2024; 76(9): 415. CrossRef
2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of the Korean Diabetes Association
Jun Sung Moon, Shinae Kang, Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, Yoon Ju Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang
Diabetes & Metabolism Journal.2024; 48(4): 546. CrossRef
Metformin inhibits OCT3-mediated serotonin transport in the placenta
Veronika Vachalova, Fiona Kumnova, Tetiana Synova, Kasin Yadunandam Anandam, Cilia Abad, Rona Karahoda, Frantisek Staud
Biomedicine & Pharmacotherapy.2024; 179: 117399. CrossRef
Effects of multidimensional exercise management on self-efficacy, blood glucose control, and delivery outcomes in pregnant women with gestational diabetes mellitus
Ying He, Xin Liu, Xiali Yang
Frontiers in Physiology.2024;[Epub] CrossRef
Letter to the Editor: Comment on “The association between prepregnancy dietary fatty acids and risk of gestational diabetes mellitus: A prospective cohort study”
Joaci Pereira dos Santos Júnior, Erika Vanesa Cadena-Burbano, Raul Manhães-de-Castro, Ana Elisa Toscano
Clinical Nutrition ESPEN.2024; 63: 694. CrossRef
Role of the "Ana Goitia" diabetes day hospital in the reduction of maternal and infant morbimortality
Cecilia Noelia Ramos, Estela Mercedes Acosta
SCT Proceedings in Interdisciplinary Insights and Innovations.2024; 2: 348. CrossRef
Lysophosphatidylcholine Impairs the Mitochondria Homeostasis Leading to Trophoblast Dysfunction in Gestational Diabetes Mellitus
Shao-Chi Hung, Te-Fu Chan, Hsiu-Chuan Chan, Chia-Ying Wu, Mei-Lin Chan, Jie-Yang Jhuang, Ji-Qin Tan, Jia-Bin Mei, Shi-Hui Law, Vinoth Kumar Ponnusamy, Hua-Chen Chan, Liang-Yin Ke
Antioxidants.2024; 13(8): 1007. CrossRef
Effect of High Glucose on Embryological Development of Zebrafish, Brachyodanio, Rerio through Wnt Pathway
Ebony Thompson, Justin Hensley, Renfang Song Taylor
International Journal of Molecular Sciences.2024; 25(17): 9443. CrossRef
Periodontitis and diabetes in pregnant rats: Maternal-fetal outcomes
Samuel Santos Souza, Larissa Lopes Cruz, Amanda Munnick Alves-Reis, Vanessa Queiros Costa, Rafaianne Queiroz Moraes-Souza, Débora Cristina Damasceno, Gustavo Tadeu Volpato
Heliyon.2024; 10(17): e37394. CrossRef
MODULAÇÃO DA MICROBIOTA INTESTINAL NO DIABETES MELLITUS GESTACIONAL: ALVO POTENCIAL TERAPÊUTICO NA ATENUAÇÃO DOS DESFECHOS ADVERSOS MATERNOS E FETAIS
Rafaela da Silva Rocha, Adrielly Suely Santos Pereira, Marília Oliveira Fonseca Goulart, Elaine Luiza Santos Soares de Mendonça, Alane Cabral Menezes de Oliveira
Revista Contemporânea.2024; 4(9): e5677. CrossRef
Gestational diabetes mellitus: ensuring healthy futures
Harriet D Morgan, Malak Hamza, Amy E Morrison, Cathy Campbell, Caroline Borg Cassar, Sheena Thayyil, Claire L Meek
British Journal of Midwifery.2024; 32(10): 552. CrossRef
Characteristics of Glucose-Lipid Metabolism in Early Pregnancy Among Overweight and Obese Women and Their Predictive Value for Gestational Diabetes Mellitus
Xia Chen, Jianmin Zhang, Yuanru Tang, Yan Zhang, Ziwen Ma, Yifan Hu
Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 3711. CrossRef
Effects of Three Exercise Interventions on Pregnancy and Neonatal Outcomes in Chinese Women with Gestational Diabetes Mellitus: A Prospective Cohort Study
Yingchun Zeng, Xiaohui Meng, Meiling Wen, Yin Qin, Xiaorong Wang, Xia Dai, Qiuhong Huang
Clinical and Experimental Obstetrics & Gynecology.2024;[Epub] CrossRef
Insulin aspart plus high-dose vitamin D supplementation for gestational diabetes mellitus: analysis of efficacy and risk factors for maternal and infant outcomes
Huiying Qiu
American Journal of Translational Research.2024; 16(8): 4200. CrossRef
Influencing factors of glycemic control in singleton pregnancies complicated by gestational diabetes mellitus in western China: A retrospective study
Jiani Zhang, Chihui Mao, Qi Cao, Guiqiong Huang, Xiaodong Wang
Medicine.2024; 103(38): e39853. CrossRef
Position statement of Italian Society of Obesity (SIO): Gestational Obesity
Luigi Barrea, Stefania Camastra, Silvia Garelli, Valeria Guglielmi, Melania Manco, Fernanda Velluzzi, Rocco Barazzoni, Ludovica Verde, Giovanna Muscogiuri
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2024;[Epub] CrossRef
The Role of Xanthine Oxidase in Pregnancy Complications: A Systematic Review
Lorenzo Annesi, Giovanni Tossetta, Claudio Borghi, Federica Piani
Antioxidants.2024; 13(10): 1234. CrossRef
Non-Pharmacological Management of Gestational Diabetes Mellitus with a High Fasting Glycemic Parameter: A Hospital-Based Study in Vietnam
Hang Giang Nguyen, Khanh Trang Huynh Nguyen, Phuc Nhon Nguyen
Journal of Clinical Medicine.2024; 13(19): 5895. CrossRef
Role of health literacy on lifestyle and glycemic control among women with diabetes during pregnancy: a cross-sectional study
Towhid Babazadeh, Sara Pourrazavi, Zahra Ardeshiri, Akbar Nadi, Khalil Maleki Chollou
Frontiers in Public Health.2024;[Epub] CrossRef
Bioinformatics-based Identification of Ferroptosis-related Genes and their Diagnostic Value in Gestational Diabetes Mellitus
Xiaomei Lv, Yujun An
Endocrine, Metabolic & Immune Disorders - Drug Targets.2024; 24(14): 1611. CrossRef
Behenic acid alleviates inflammation and insulin resistance in gestational diabetes mellitus by regulating TLR4/NF-κB signaling pathway
Kerong Liu, Ying Gu, Xingnan Pan, Sha Chen, Jie Cheng, Le Zhang, Minkai Cao
iScience.2024; 27(10): 111019. CrossRef
Quantitative Analysis of Myocardial Work in Gestational Diabetes Mellitus Using Noninvasive Left Ventricular Pressure‐Strain Loop Measurement
Jiaqi Zhang, Caihong Chang, Changxiu Yu, Yao Peng, Wei Feng, Juan Song, Ji Wu
Echocardiography.2024;[Epub] CrossRef
Association of joint exposure to organophosphorus flame retardants and phthalate acid esters with gestational diabetes mellitus: a nested case-control study
Qi Lang, Xianfeng Qin, Xiangyuan Yu, Shudan Wei, Jinyan Wei, Min Zhang, Chaochao Zhao, Jun Zhang, Dingyuan Zeng, Xiaoying Zhang, Bo Huang
BMC Pregnancy and Childbirth.2024;[Epub] CrossRef
Amelioration of Insulin Resistance after Delivery Is Associated with Reduced Risk of Postpartum Diabetes in Women with Gestational Diabetes Mellitus
Heejun Son, Joon Ho Moon, Sung Hee Choi, Nam H. Cho, Soo Heon Kwak, Hak Chul Jang
Endocrinology and Metabolism.2024; 39(5): 701. CrossRef
Are Maternal Dietary Patterns During Pregnancy Associated with the Risk of Gestational Diabetes Mellitus? A Systematic Review of Observational Studies
Charikleia Kyrkou, Apostolos P. Athanasiadis, Michael Chourdakis, Stefania Kada, Costas G. Biliaderis, Georgios Menexes, Alexandra-Maria Michaelidou
Nutrients.2024; 16(21): 3632. CrossRef
Gestational diabetes mellitus – Can we do better with postpartum diabetes screening?
Hadas Zafrir-Danieli, Ohad Houri, Reut Rotem, Dror Weinberg-Almog, Or Bercovich, Eran Hadar, Alexandra Berezowsky
European Journal of Obstetrics & Gynecology and Reproductive Biology.2024; 303: 153. CrossRef
Dietary inflammatory index as a predictor of prediabetes in women with previous gestational diabetes mellitus
Yanhong Xu, Zhiying Yao, Jiayi Lin, Nan Wei, Ling Yao
Diabetology & Metabolic Syndrome.2024;[Epub] CrossRef
Influence of Nutrition on Growth and Development of Metabolic Syndrome in Children
Alessia Quarta, Maria Teresa Quarta, Concetta Mastromauro, Francesco Chiarelli, Cosimo Giannini
Nutrients.2024; 16(22): 3801. CrossRef
Usefulness of Glycated Albumin Levels in Predicting the Maternal or Neonatal Complications of Gestational Diabetes Mellitus during Late Pregnancy in South Korea: A Retrospective Study
Jihan Kim, Sami Lee, Jong Sung Kim
Korean Journal of Family Medicine.2024;[Epub] CrossRef
Combination of body mass index and body fat percentage in middle and late pregnancy to predict pregnancy outcomes in patients with gestational diabetes in Wenzhou, China: a single-centre retrospective cohort study
Bingru Chen, Lanxi Chen, Xiner Zhao, Tao You, Zhi Zheng, Yilin Chen, Shuoru Zhu
BMJ Open.2024; 14(11): e086703. CrossRef
The Predictive Power of the Mother’s Neck Circumference in the Early Diagnosis of Gestational Diabetes Mellitus
Mahin Balouchi Mahani, Mahtab Sattari, Akbar Mehralizade, Azam Amirian
Journal of Nursing and Midwifery Sciences.2024;[Epub] CrossRef
Insights into the pathogenesis of gestational and hepatic diseases: the impact of ferroptosis
Yilan You, Zhiwen Qian, Ying Jiang, Lingyan Chen, Danping Wu, Lu Liu, Feng Zhang, Xin Ning, Yan Zhang, Jianping Xiao
Frontiers in Cell and Developmental Biology.2024;[Epub] CrossRef
The effect of diabetes education on maternal and neonatal outcomes in pregnant women diagnosed with gestational diabetes
Serap Topkara, Çağanay Soysal
BMC Pregnancy and Childbirth.2024;[Epub] CrossRef
Administration of a diabetes-specific formula can improve postprandial glycemic control and delay insulin use in gestational diabetes mellitus: A randomized controlled trial from two centers
Ruihua Yang, Weiling Han, Wei Zheng, Dong Xu, Jing He, Xianxian Yuan, Li Zhang, Zhihong Tian, Guanghui Li
Clinical Nutrition.2024; 43(12): 265. CrossRef
Circ‐ADAM9 Knockdown Reduces Insulin Resistance and Placental Injury in Diabetic Mice via MAPK Pathway Inactivation
Ai Zhao, Yawen Yang, Yijun Yang, Zhenjing Chi, Yanlan Sun
American Journal of Reproductive Immunology.2024;[Epub] CrossRef
The Efficacy and Acceptability of Flash Glucose Monitoring in Pregnant Women with Gestational Diabetes Mellitus: A Systematic Review
Franciszek Ługowski, Julia Babińska, Zofia Awiżeń-Panufnik, Ewelina Litwińska-Korcz, Magdalena Litwińska, Artur Ludwin, Paweł Jan Stanirowski
Journal of Clinical Medicine.2024; 13(23): 7129. CrossRef
Impact of Gestational Diabetes Mellitus on Fetal Growth and Nutritional Status in Newborns
Karolina Karcz, Barbara Królak-Olejnik
Nutrients.2024; 16(23): 4093. CrossRef
Association of overweight and obesity with gestational diabetes mellitus among pregnant women attending antenatal care clinics in Addis Ababa, Ethiopia: a case-control study
Yeabsra Mesfin Seifu, Negussie Deyessa, Yimer Seid Yimer
BMJ Open.2024; 14(11): e082539. CrossRef
Gestational diabetes mellitus and risk of neonatal respiratory distress syndrome: a systematic review and meta-analysis
Fang Yang, Hua Liu, Cuixia Ding
Diabetology & Metabolic Syndrome.2024;[Epub] CrossRef
Gestational Diabetes, the Human Milk Metabolome, and Infant Growth and Adiposity
Emily M. Nagel, Armando Peña, Jonathan M. Dreyfuss, Eric F. Lock, Kelsey E. Johnson, Chang Lu, David A. Fields, Ellen W. Demerath, Elvira Isganaitis
JAMA Network Open.2024; 7(12): e2450467. CrossRef
Prediction of Possible Adverse Effects of Gestational Diabetes Mellitus on Maternal and Fetal Glomeruli by Urine and Amniotic Fluid Podocyte Degradation Products
Fatma Tanilir Cagiran, Nihal Mavral, Zercan Kali, Pinar Kirici
Diagnostics.2024; 14(24): 2771. CrossRef
LncRNAs Involved in Antioxidant Response Regulation as Biomarkers of Gestational Diabetes: A Study on H19, MALAT1 and MEG3
Jovana Stevanović, Uroš Petrović, Ana Penezić, Ognjen Radojičić, Daniela Ardalić, Milica Mandić, Vesna Mandić-Marković, Željko Miković, Miloš Brkušanin, Olgica Nedić, Zorana Dobrijević
Antioxidants.2024; 13(12): 1503. CrossRef
Decreased telomerase activity and shortened telomere length in infants whose mothers have gestational diabetes mellitus and increased severity of telomere shortening in male infants
Shuhua Liu, Liping Xu, Yan Cheng, Dehong Liu, Bin Zhang, Xianxia Chen, Mingming Zheng
Frontiers in Endocrinology.2024;[Epub] CrossRef
Infants of Diabetic Mothers and Associated Complications in the Neonatal Intensive Care Unit
Hussain A Al Ghadeer, Ahad A Mohamed , Mariam A Alali, Kulthum A Al Mahdi, Sajeda M Almishal, Tawfiq M Aljubran, Abdulelah A Alneamah , Roaa S Alduhmush , Mohammed J Alobaid , Tarfh S Alsaad , Hayam S Almoagal, Abdullah M Albuali , Mudhawi F Alsu
Cureus.2024;[Epub] CrossRef
U-shaped Association Between Folic Acid Supplementation and the Risk of Gestational Diabetes Mellitus in Chinese Women
Jiuming Zou, Qiang Fu, Xiaoliu Huang, Zhao Yao, Weiye Wang
Canadian Journal of Diabetes.2023; 47(1): 78. CrossRef
Vitamin D Supplementation for the Outcomes of Patients with Gestational Diabetes Mellitus and Neonates: A Meta-Analysis and Systematic Review
Chunfeng Wu, Yang Song, Xueying Wang, Pier P. Sainaghi
International Journal of Clinical Practice.2023; 2023: 1. CrossRef
Lipolysis and gestational diabetes mellitus onset: a case-cohort genome-wide association study in Chinese
Miao Zhang, Qing Li, Kai-Lin Wang, Yao Dong, Yu-Tong Mu, Yan-Min Cao, Jin Liu, Zi-Heng Li, Hui-Lu Cui, Hai-Yan Liu, An-Qun Hu, Ying-Jie Zheng
Journal of Translational Medicine.2023;[Epub] CrossRef
Interactive effect of prepregnancy overweight/obesity and GDM history on prevalence of GDM in biparous women
Xia Xu, Feipeng Huang, Yanni Guo, Lianghui Zheng, Jianying Yan
Frontiers in Endocrinology.2023;[Epub] CrossRef
Microbiome Changes in Pregnancy Disorders
Luca Giannella, Camilla Grelloni, Dayana Quintili, Alessia Fiorelli, Ramona Montironi, Sonila Alia, Giovanni Delli Carpini, Jacopo Di Giuseppe, Arianna Vignini, Andrea Ciavattini
Antioxidants.2023; 12(2): 463. CrossRef
Effects of early standardized management on the growth trajectory of offspring with gestational diabetes mellitus at 0–5 years old: a preliminary longitudinal study
Bingbing Guo, Jingjing Pei, Yin Xu, Yajie Wang, Xinye Jiang
Scientific Reports.2023;[Epub] CrossRef
Prediction model for gestational diabetes mellitus using the XG Boost machine learning algorithm
Xiaoqi Hu, Xiaolin Hu, Ya Yu, Jia Wang
Frontiers in Endocrinology.2023;[Epub] CrossRef
Prevalence and outcomes of gestational diabetes mellitus in Indian women: Insights from a large real-world study over ten years at tertiary care research institute
Sanjay Gupte, Gayatri Venkataraman, Aarti S. Shah, Shalaka Jamenis, Chandrakant Rao, Shweta M. Jangam, Kaveri M. Adki, Onkar C. Swami
International Journal of Diabetes in Developing Countries.2023; 43(4): 511. CrossRef
Gestational diabetes mellitus: state of art
S. A. Pletneva, E. V. Enkova, O. V. Khoperskaya, S. V. Shamarin, V. V. Enkova
Meditsinskiy sovet = Medical Council.2023; (5): 136. CrossRef
Effect of folic acid supplementation in the association between short sleep duration and gestational diabetes mellitus
Zhen Yang, Sisi Hu, Wei Tong, Zhihao Xu, Xiaoliu Huang, Weiye Wang
Sleep and Breathing.2023; 27(6): 2509. CrossRef
Birth weight and large for gestational age trends in offspring of pregnant women with gestational diabetes mellitus in southern China, 2012-2021
Li-Rong He, Li Yu, Yong Guo
Frontiers in Endocrinology.2023;[Epub] CrossRef
Root causes of long-term complications of gestational diabetes mellitus: Metabolic disturbances of the host and gut microbiota
Mingjin Tao, Gaochen Lu, Sheng Zhang, Pan Li
Clinica Chimica Acta.2023; 548: 117490. CrossRef
Analysis on Related Risk Factors for Gestational Diabetes Mellitus (GDM) in Subsequent Pregnancies in Multiparous Women with No History of GDM
文静张
Advances in Clinical Medicine.2023; 13(07): 11628. CrossRef
Fetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: A potential threat for programming cardiovascular disease
Mariana S. Diniz, Ursula Hiden, Inês Falcão-Pires, Paulo J. Oliveira, Luis Sobrevia, Susana P. Pereira
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(8): 166834. CrossRef
Diagnosis and management of gestational diabetes mellitus
Tae Jung Oh
Journal of the Korean Medical Association.2023; 66(7): 414. CrossRef
Hypoglycemia in Children: Major Endocrine-Metabolic Causes and Novel Therapeutic Perspectives
Alessia Quarta, Daniela Iannucci, Miriana Guarino, Annalisa Blasetti, Francesco Chiarelli
Nutrients.2023; 15(16): 3544. CrossRef
Relation between weight gain during pregnancy and postpartum reclassification in gestational diabetes
Sofia Coelho, Marta Canha, Ana Rita Leite, João Sérgio Neves, Ana Isabel Oliveira, Davide Carvalho, Maria do Céu Ameida
Endocrine.2023; 82(2): 296. CrossRef
Nurturing through Nutrition: Exploring the Role of Antioxidants in Maternal Diet during Pregnancy to Mitigate Developmental Programming of Chronic Diseases
Mariana S. Diniz, Carina C. Magalhães, Carolina Tocantins, Luís F. Grilo, José Teixeira, Susana P. Pereira
Nutrients.2023; 15(21): 4623. CrossRef
Blood manganese level and gestational diabetes mellitus: a systematic review and meta-analysis
Yingmei Sun, Yu Zhang
Journal of Obstetrics and Gynaecology.2023;[Epub] CrossRef
Multiparity increases the risk of diabetes by impairing the proliferative capacity of pancreatic β cells
Joon Ho Moon, Joonyub Lee, Kyun Hoo Kim, Hyun Jung Kim, Hyeongseok Kim, Hye-Na Cha, Jungsun Park, Hyeonkyu Lee, So-young Park, Hak Chul Jang, Hail Kim
Experimental & Molecular Medicine.2023; 55(10): 2269. CrossRef
Physiological Mechanisms Inherent to Diabetes Involved in the Development of Dementia: Alzheimer’s Disease
Himan Mohamed-Mohamed, Victoria García-Morales, Encarnación María Sánchez Lara, Anabel González-Acedo, Teresa Pardo-Moreno, María Isabel Tovar-Gálvez, Lucía Melguizo-Rodríguez, Juan José Ramos-Rodríguez
Neurology International.2023; 15(4): 1253. CrossRef
Synergistic effect between pre-pregnancy smoking and assisted reproductive technology on gestational diabetes mellitus in twin pregnancies
Lingyu Zhang, Yan Huang, Mingjin Zhang, Yanqi Jin
Acta Diabetologica.2023; 61(2): 205. CrossRef
A Comprehensive Review of Gestational Diabetes Mellitus: Impacts on Maternal Health, Fetal Development, Childhood Outcomes, and Long-Term Treatment Strategies
Vaishnavi S Nakshine, Sangita D Jogdand
Cureus.2023;[Epub] CrossRef
The role of dietary fiber on preventing gestational diabetes mellitus in an at-risk group of high triglyceride-glucose index women: a randomized controlled trial
Yannan Cao, Jing Sheng, Dongyao Zhang, Li Chen, Ying Jiang, Decui Cheng, Yao Su, Yuexin Yu, Haoyi Jia, Pengyuan He, Li Wang, Xianming Xu
Endocrine.2023; 82(3): 542. CrossRef
Correlation between PAPP-A serum levels in the first trimester of pregnancy with the occurrence of gestational diabetes, a multicenter cohort study
Sedigheh Borna, Masoumeh Ashrafzadeh, Marjan Ghaemi, Nasim Eshraghi, Nafiseh Hivechi, Sedigheh Hantoushzadeh
BMC Pregnancy and Childbirth.2023;[Epub] CrossRef
Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
Erika Di Zazzo, Sergio Davinelli, Serena Panichella, Giovanni Scapagnini, Mariano Intrieri, Silvio Garofalo
Open Medicine.2023;[Epub] CrossRef
Advancements in Nutritional Strategies for Gestational Diabetes Management: A Systematic Review of Recent Evidence
Juan Carlos Sánchez-García, Ines Saraceno López-Palop, Beatriz Piqueras-Sola, Jonathan Cortés-Martín, Elena Mellado-García, Inmaculada Muñóz Sánchez, Raquel Rodríguez-Blanque
Journal of Clinical Medicine.2023; 13(1): 37. CrossRef
Neuroprotective Potential of Punicalagin, a Natural Component of Pomegranate Polyphenols: A Review
Peng Chen, ZhiLei Guo, Benhong Zhou
Journal of Integrative Neuroscience.2023;[Epub] CrossRef
Comparative efficacy and safety of glyburide, metformin, and insulin in treatment of gestational diabetes mellitus
Jing Lin, Rong-zu Tu, Xun-yu Hong
Medicine.2022;[Epub] CrossRef
Stacking Ensemble Method for Gestational Diabetes Mellitus Prediction in Chinese Pregnant Women: A Prospective Cohort Study
Ruiyi Liu, Yongle Zhan, Xuan Liu, Yifang Zhang, Luting Gui, Yimin Qu, Hairong Nan, Yu Jiang, Mehdi Gheisari
Journal of Healthcare Engineering.2022; 2022: 1. CrossRef
Secular increase in the prevalence of gestational diabetes and its associated adverse pregnancy outcomes from 2014 to 2021 in Hebei province, China
Mei-Ling Tian, Li-Yan Du, Guo-Juan Ma, Ting Zhang, Xu-Yuan Ma, Ying-Kui Zhang, Zeng-Jun Tang
Frontiers in Endocrinology.2022;[Epub] CrossRef
Aquaporin-8 overexpression is involved in vascular structure and function changes in placentas of gestational diabetes mellitus patients
Yanxing Shan, Jiawen Cui, Xinyi Kang, Weichun Tang, Yiling Lu, Ying Gao, Liping Chen
Open Life Sciences.2022; 17(1): 1473. CrossRef
Vitamin D status and levels of pro-inflammatory cytokines in newborns born to mothers with endocrine diseases
N. E. Verisokina, L. Ya. Klimov, I. N. Zakharova, A. L. Zaplatnikov, V. V. Zubkov, A. A. Momotova, V. A. Kuryaninova, R. A. Atanesyan, T. V. Zhelezniakova, M. A. Petrosyan, D. V. Bobryshev, D. A. Volkov, Z. A. Magomadova
Meditsinskiy sovet = Medical Council.2022; (19): 9. CrossRef
IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies
Aleksandra Vilotić, Mirjana Nacka-Aleksić, Andrea Pirković, Žanka Bojić-Trbojević, Dragana Dekanski, Milica Jovanović Krivokuća
International Journal of Molecular Sciences.2022; 23(23): 14574. CrossRef
Higher Muscle Mass Protects Women with Gestational Diabetes Mellitus from Progression to Type 2 Diabetes Mellitus
Yujin Shin, Joon Ho Moon, Tae Jung Oh, Chang Ho Ahn, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang
Diabetes & Metabolism Journal.2022; 46(6): 890. CrossRef
Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus
Yindi Bao, Jun Zhang, Yi Liu, Lianzhi Wu, Jing Yang
Frontiers in Genetics.2022;[Epub] CrossRef
The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders
Mirjana Nacka-Aleksić, Andrea Pirković, Aleksandra Vilotić, Žanka Bojić-Trbojević, Milica Jovanović Krivokuća, Francesca Giampieri, Maurizio Battino, Dragana Dekanski
Nutrients.2022; 14(24): 5246. CrossRef

Short Communication

Metabolic Risk/Epidemiology
Influence of Pre-Pregnancy Underweight Body Mass Index on Fetal Abdominal Circumference, Estimated Weight, and Pregnancy Outcomes in Gestational Diabetes Mellitus: Minji Kim, Kyu-Yeon Hur, Suk-Joo Choi, Soo-Young Oh, Cheong-Rae Roh; Diabetes Metab J. 2022;46(3):499-505. Published online January 24, 2022; DOI: https://doi.org/10.4093/dmj.2021.0059

7,479 View
234 Download
4 Web of Science
4 Crossref

Abstract PDF Supplementary Material PubReader ePub

This study aimed to determine the influence of pre-pregnancy body mass index on pregnancy outcomes in gestational diabetes mellitus (GDM), comparing underweight patients with GDM with normal weight patients with GDM. Maternal baseline characteristics, ultrasonographic results, and pregnancy and neonatal outcomes were reviewed in 946 women with GDM with singleton pregnancies. Underweight patients with GDM showed a benign course in most aspects during pregnancy, except for developing a higher risk of giving birth to small for gestational age neonates. Underweight women with GDM required less insulin treatment, had a higher rate of vaginal delivery, and had a lower rate of cesarean delivery. In addition, their neonates were more likely to have fetal abdominal circumference and estimated fetal weight below the 10th percentile both at the time of GDM diagnosis and before delivery. Notably, their risk for preeclampsia and macrosomia were lower. Collectively, our data suggest that underweight women with GDM may require a different approach in terms of diagnosis and management throughout their pregnancy.

Citations

Citations to this article as recorded by

Challenges in the management of gestational diabetes mellitus in anorexia nervosa
Rija Siddiqui, Carrie J McAdams
Psychiatry Research Case Reports.2024; 3(1): 100215. CrossRef
Is gestational diabetes mellitus in lean women a distinct entity warranting a modified management approach?
Pradnyashree Wadivkar, Meredith Hawkins
Frontiers in Clinical Diabetes and Healthcare.2024;[Epub] CrossRef
Obesity Is Associated With Higher Risk of Adverse Maternal and Neonatal Outcomes Than Supervised Gestational Diabetes
Namju Seo, You Min Lee, Ye-jin Kim, Ji-hee Sung, Kyu-Yeon Hur, Suk-Joo Choi, Cheong-Rae Roh, Soo-young Oh
Journal of Korean Medical Science.2023;[Epub] CrossRef
Maternal pre-pregnancy obesity modifies the association between first-trimester thyroid hormone sensitivity and gestational Diabetes Mellitus: a retrospective study from Northern China
Honglin Sun, Yibo Zhou, Jia Liu, Ying Wang, Guang Wang
Diabetology & Metabolic Syndrome.2023;[Epub] CrossRef

Original Articles

Metabolic Risk/Epidemiology
Postprandial Free Fatty Acids at Mid-Pregnancy Increase the Risk of Large-for-Gestational-Age Newborns in Women with Gestational Diabetes Mellitus: So-Yeon Kim, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyung-Soo Kim; Diabetes Metab J. 2022;46(1):140-148. Published online August 9, 2021; DOI: https://doi.org/10.4093/dmj.2021.0023

7,012 View
178 Download
6 Web of Science
6 Crossref

Graphical Abstract Abstract PDF Supplementary Material PubReader ePub

Background
To investigate the association between free fatty acid (FFA) level at mid-pregnancy and large-for-gestational-age (LGA) newborns in women with gestational diabetes mellitus (GDM).
Methods
We enrolled 710 pregnant women diagnosed with GDM from February 2009 to October 2016. GDM was diagnosed by a ‘two-step’ approach with Carpenter and Coustan criteria. We measured plasma lipid profiles including fasting and 2-hour postprandial FFA (2h-FFA) levels at mid-pregnancy. LGA was defined if birthweights of newborns were above the 90th percentile for their gestational age.
Results
Mean age of pregnant women in this study was 33.1 years. Mean pre-pregnancy body mass index (BMI) was 22.4 kg/m². The prevalence of LGA was 8.3% (n=59). Levels of 2h-FFA were higher in women who delivered LGA newborns than in those who delivered non-LGA newborns (416.7 μEq/L vs. 352.5 μEq/L, P=0.006). However, fasting FFA was not significantly different between the two groups. The prevalence of delivering LGA newborns was increased with increasing tertile of 2h-FFA (T1, 4.3%; T2, 9.8%; T3, 10.7%; P for trend <0.05). After adjustment for maternal age, pre-pregnancy BMI, and fasting plasma glucose, the highest tertile of 2h-FFA was 2.38 times (95% confidence interval, 1.11 to 5.13) more likely to have LGA newborns than the lowest tertile. However, there was no significant difference between groups according to fasting FFA tertiles.
Conclusion
In women with GDM, a high 2h-FFA level (but not fasting FFA) at mid-pregnancy is associated with an increasing risk of delivering LGA newborns.

Citations

Citations to this article as recorded by

Longitudinal Trajectory of Free Fatty Acids in Pregnancy According to First-Trimester Maternal Metabolic Status and the Presence of Gestational Diabetes
Otilia Perichart-Perera, Isabel González-Ludlow, Omar Piña-Ramírez, Maricruz Tolentino-Dolores, Guadalupe Estrada-Gutierrez, Sandra B. Parra-Hernández, Maribel Sánchez-Martínez, Omar Granados-Portillo, Ameyalli M. Rodríguez-Cano
Metabolites.2025; 15(5): 320. CrossRef
Application and effectiveness study of tripartite linkage nursing in prediabetes type 2 diabetes: A retrospective study
Jiao Chen, Juan Wang, Zhongwen Wang, Mei Huang, Meixiang Luo, Yanyu Cai
Medicine.2025; 104(19): e42138. CrossRef
Advances in free fatty acid profiles in gestational diabetes mellitus
Haoyi Du, Danyang Li, Laura Monjowa Molive, Na Wu
Journal of Translational Medicine.2024;[Epub] CrossRef
Association between serum free fatty acids and gestational diabetes mellitus
Danyang Li, Haoyi Du, Na Wu
Frontiers in Endocrinology.2024;[Epub] CrossRef
Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids
Aijun Tong, Weihao Wu, Zhengxin Chen, Jiahui Wen, Ruibo Jia, Bin Liu, Hui Cao, Chao Zhao
Current Research in Food Science.2023; 6: 100427. CrossRef
Fetal Abdominal Obesity Detected at 24 to 28 Weeks of Gestation Persists until Delivery Despite Management of Gestational Diabetes Mellitus (Diabetes Metab J 2021;45:547-57)
Wonjin Kim, Soo Kyung Park, Yoo Lee Kim
Diabetes & Metabolism Journal.2021; 45(6): 970. CrossRef

Metabolic Risk/Epidemiology
Fetal Abdominal Obesity Detected At 24 to 28 Weeks of Gestation Persists Until Delivery Despite Management of Gestational Diabetes Mellitus: Wonjin Kim, Soo Kyung Park, Yoo Lee Kim; Diabetes Metab J. 2021;45(4):547-557. Published online March 5, 2021; DOI: https://doi.org/10.4093/dmj.2020.0078

7,903 View
203 Download
11 Web of Science
7 Crossref

Graphical Abstract Abstract PDF Supplementary Material PubReader ePub

Background
Fetal abdominal obesity (FAO) has been reported to be affected at gestational diabetes mellitus (GDM) diagnosis at 24 to 28 weeks of gestation in older and/or obese women. This study investigated whether the management of GDM improves FAO in GDM subjects near term.
Methods
Medical records of 7,099 singleton pregnant women delivering at CHA Gangnam Medical Center were reviewed retrospectively. GDM was diagnosed by 100-g oral glucose tolerance test after 50-g glucose challenge test based on Carpenter–Coustan criteria. GDM subjects were divided into four study groups according to maternal age and obesity. FAO was defined as ≥90th percentile of fetal abdominal overgrowth ratios (FAORs) of the ultrasonographically estimated gestational age (GA) of abdominal circumference per actual GA by the last menstruation period, biparietal diameter, or femur length, respectively.
Results
As compared with normal glucose tolerance (NGT) subjects near term, FAORs and odds ratio for FAO were significantly higher in old and/or obese women with GDM but not in young and nonobese women with GDM. For fetuses of GDM subjects with FAO at the time of GDM diagnosis, the odds ratio for exhibiting FAO near term and being large for GA at birth were 7.87 (95% confidence interval [CI], 4.38 to 14.15) and 10.96 (95% CI, 5.58 to 20.53) compared with fetuses of NGT subjects without FAO at GDM diagnosis.
Conclusion
Despite treatment, FAO detected at the time of GDM diagnosis persisted until delivery. Early diagnosis and treatment might be necessary to prevent near term FAO in high-risk older and/or obese women.

Citations

Citations to this article as recorded by

Early-life exposure to gestational diabetes mellitus predisposes offspring to pediatric nonalcoholic fatty liver disease
Qian-Ren Zhang, Yan Dong, Jian-Gao Fan
Hepatobiliary & Pancreatic Diseases International.2025; 24(2): 128. CrossRef
Gestational diabetes mellitus management according to ultrasound fetal growth versus strict glycemic treatment in singleton pregnancies: A systematic review and meta‐analysis of clinical trials
Ana M. Fernández‐Alonso, Angélica Monterrosa‐Blanco, Álvaro Monterrosa‐Castro, Faustino R. Pérez‐López
Journal of Obstetrics and Gynaecology Research.2024; 50(10): 1759. CrossRef
A machine learning-based clinical decision support system for effective stratification of gestational diabetes mellitus and management through Ayurveda
Nisha P. Shetty, Jayashree Shetty, Veeraj Hegde, Sneha Dattatray Dharne, Mamtha Kv
Journal of Ayurveda and Integrative Medicine.2024; 15(6): 101051. CrossRef
The effects of gestational diabetes mellitus on fetal growth: is it different for low-risk and medium–high-risk pregnant women?
Jie Wang, Xin Cheng, Zhen-Hua Li, Yi-Cheng Mao, Xin-Qiang Wang, Kang-Di Zhang, Wen-Jie Yu, Ying-Qing Li, Jia-wen Zhao, Mao-Lin Chen, Guo-peng Gao, Cheng-Yang Hu, Xiu-Jun Zhang
Archives of Gynecology and Obstetrics.2023; 310(2): 833. CrossRef
Fetal abdominal obesity and the ensuing adverse perinatal outcomes in older obese pregnant women with or without obesity and with normal glucose tolerance
Wonjin Kim, Soo Kyung Park, Yoo Lee Kim
Scientific Reports.2023;[Epub] CrossRef
Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis
Wenrui Ye, Cong Luo, Jing Huang, Chenglong Li, Zhixiong Liu, Fangkun Liu
BMJ.2022; : e067946. CrossRef
Fetal abdominal overgrowth is already present at 20–24 gestational weeks prior to diagnosis of gestational diabetes mellitus
Wonjin Kim, Soo Kyung Park, Yoo Lee Kim
Scientific Reports.2021;[Epub] CrossRef

Metabolic Risk/Epidemiology
Maternal Hyperglycemia during Pregnancy Increases Adiposity of Offspring: Hye Rim Chung, Joon Ho Moon, Jung Sub Lim, Young Ah Lee, Choong Ho Shin, Joon-Seok Hong, Soo Heon Kwak, Sung Hee Choi, Hak Chul Jang; Diabetes Metab J. 2021;45(5):730-738. Published online February 22, 2021; DOI: https://doi.org/10.4093/dmj.2020.0154

7,565 View
206 Download
11 Web of Science
12 Crossref

Graphical Abstract Abstract PDF Supplementary Material PubReader ePub

Background
The effect of intrauterine hyperglycemia on fat mass and regional fat proportion of the offspring of mothers with gestational diabetes mellitus (OGDM) remains to be determined.
Methods
The body composition of OGDM (n=25) and offspring of normoglycemic mothers (n=49) was compared using dualenergy X-ray absorptiometry at age 5 years. The relationship between maternal glucose concentration during a 100 g oral glucose tolerance test (OGTT) and regional fat mass or proportion was analyzed after adjusting for maternal prepregnancy body mass index (BMI).
Results
BMI was comparable between OGDM and control (median, 16.0 kg/m² vs. 16.1 kg/m² ). Total, truncal, and leg fat mass were higher in OGDM compared with control (3,769 g vs. 2,245 g, P=0.004; 1,289 g vs. 870 g, P=0.017; 1,638 g vs. 961 g, P=0.002, respectively), whereas total lean mass was lower in OGDM (15,688 g vs. 16,941 g, P=0.001). Among OGDM, total and truncal fat mass were correlated with fasting and 3-hour glucose concentrations of maternal 100 g OGTT during pregnancy (total fat mass, r=0.49, P=0.018 [fasting], r=0.473, P=0.023 [3-hour]; truncal fat mass, r=0.571, P=0.004 [fasting], r=0.558, P=0.006 [3-hour]), but there was no correlation between OGDM leg fat mass and maternal OGTT during pregnancy. Regional fat indices were not correlated with concurrent maternal 75 g OGTT values.
Conclusion
Intrauterine hyperglycemia is associated with increased fat mass, especially truncal fat, in OGDM aged 5 years.

Citations

Citations to this article as recorded by

Maternal high-fat diet programs offspring airway hyperinnervation and hyperresponsiveness
Kayla R. Williams, Hoyt A.T.K. Bright, Allison D. Fryer, David B. Jacoby, Zhenying Nie
JCI Insight.2025;[Epub] CrossRef
Gestational Diabetes Mellitus: Mechanisms Underlying Maternal and Fetal Complications
Jooyeop Lee, Na Keum Lee, Joon Ho Moon
Endocrinology and Metabolism.2025; 40(1): 10. CrossRef
Unveiling Gestational Diabetes: An Overview of Pathophysiology and Management
Rahul Mittal, Karan Prasad, Joana R. N. Lemos, Giuliana Arevalo, Khemraj Hirani
International Journal of Molecular Sciences.2025; 26(5): 2320. CrossRef
Advances in free fatty acid profiles in gestational diabetes mellitus
Haoyi Du, Danyang Li, Laura Monjowa Molive, Na Wu
Journal of Translational Medicine.2024;[Epub] CrossRef
2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of the Korean Diabetes Association
Jun Sung Moon, Shinae Kang, Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, Yoon Ju Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang
Diabetes & Metabolism Journal.2024; 48(4): 546. CrossRef
Type 1 Diabetes and Pregnancy: Challenges in Glycemic Control and Maternal–Fetal Outcomes
Tejumola Apata, Dennis Samuel, Laticia Valle, Sarah D. Crimmins
Seminars in Reproductive Medicine.2024; 42(03): 239. CrossRef
Association between serum free fatty acids and gestational diabetes mellitus
Danyang Li, Haoyi Du, Na Wu
Frontiers in Endocrinology.2024;[Epub] CrossRef
High-fat diet during pregnancy lowers fetal weight and has a long-lasting adverse effect on brown adipose tissue in the offspring
Mihoko Yamaguchi, Jun Mori, Nozomi Nishida, Satoshi Miyagaki, Yasuhiro Kawabe, Takeshi Ota, Hidechika Morimoto, Yusuke Tsuma, Shota Fukuhara, Takehiro Ogata, Takuro Okamaura, Naoko Nakanishi, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Tomoko I
Journal of Developmental Origins of Health and Disease.2023; 14(2): 261. CrossRef
Prediction of gestational diabetes mellitus in Asian women using machine learning algorithms
Byung Soo Kang, Seon Ui Lee, Subeen Hong, Sae Kyung Choi, Jae Eun Shin, Jeong Ha Wie, Yun Sung Jo, Yeon Hee Kim, Kicheol Kil, Yoo Hyun Chung, Kyunghoon Jung, Hanul Hong, In Yang Park, Hyun Sun Ko
Scientific Reports.2023;[Epub] CrossRef
Effects of early standardized management on the growth trajectory of offspring with gestational diabetes mellitus at 0–5 years old: a preliminary longitudinal study
Bingbing Guo, Jingjing Pei, Yin Xu, Yajie Wang, Xinye Jiang
Scientific Reports.2023;[Epub] CrossRef
Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications
Joon Ho Moon, Hak Chul Jang
Diabetes & Metabolism Journal.2022; 46(1): 3. CrossRef
Increased Pro-Inflammatory T Cells, Senescent T Cells, and Immune-Check Point Molecules in the Placentas of Patients With Gestational Diabetes Mellitus
Yea Eun Kang, Hyon-Seung Yi, Min-Kyung Yeo, Jung Tae Kim, Danbit Park, Yewon Jung, Ok Soon Kim, Seong Eun Lee, Ji Min Kim, Kyong Hye Joung, Ju Hee Lee, Bon Jeong Ku, Mina Lee, Hyun Jin Kim
Journal of Korean Medical Science.2022;[Epub] CrossRef

Metabolic Risk/Epidemiology
A Vegetable Dietary Pattern Is Associated with Lowered Risk of Gestational Diabetes Mellitus in Chinese Women: Qiong Chen, Weiwei Wu, Hailan Yang, Ping Zhang, Yongliang Feng, Keke Wang, Ying Wang, Suping Wang, Yawei Zhang; Diabetes Metab J. 2020;44(6):887-896. Published online September 11, 2020; DOI: https://doi.org/10.4093/dmj.2019.0138

8,571 View
160 Download
16 Web of Science
17 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Identification of modifiable dietary factors, which are involved in the development of gestational diabetes mellitus (GDM), could inform strategies to prevent GDM.
Methods
We examined the dietary patterns in a Chinese population and evaluated their relationship with GDM risk using a case-control study including 1,464 cases and 8,092 control subjects. Propensity score matching was used to reduce the imbalance of covariates between cases and controls. Dietary patterns were identified using factor analysis while their associations with GDM risk were evaluated using logistic regression models.
Results
A “vegetable” dietary pattern was characterized as the consumption of green leafy vegetables (Chinese little greens and bean seedling), other vegetables (cabbages, carrots, tomatoes, eggplants, potatoes, mushrooms, peppers, bamboo shoots, agarics, and garlic), and bean products (soybean milk, tofu, kidney beans, and cowpea). For every quartile increase in the vegetables factor score during 1 year prior to conception, the first trimester, and the second trimester of pregnancy, the GDM risk lowered by 6% (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.89 to 0.99), 7% (OR, 0.94; 95% CI, 0.88 to 0.99), and 9% (OR, 0.91; 95% CI, 0.86 to 0.96).
Conclusion
In conclusion, our study suggests that the vegetable dietary pattern is associated with lower GDM risk; however, the interpretation of the result should with caution due to the limitations in our study, and additional studies are necessary to explore the underlying mechanism of this relationship.

Citations

Citations to this article as recorded by

Signature of pre-pregnancy microbiome in infertile women undergoing frozen embryo transfer with gestational diabetes mellitus
Wenzheng Guan, Tian Zhou, Jiao Jiao, Liwen Xiao, Zhen Wang, Siyuan Liu, Fujie Yan, Fangqing Zhao, Xiuxia Wang
npj Biofilms and Microbiomes.2025;[Epub] CrossRef
Moderate Chili Consumption During Pregnancy Is Associated with a Low Risk of Gestational Diabetes (GDM)
Xiaozhong Wen, Fatima Makama, Ryan Buzby, Jeremy Nguyen, Rose Durnell, Iyobosa Ekhator, Daren Chan, Todd C. Rideout
Nutrients.2025; 17(6): 1025. CrossRef
Association of Food-Specific Glycemic Load and Distinct Dietary Components with Gestational Diabetes Mellitus Within a Mediterranean Dietary Pattern: A Prospective Cohort Study
Antigoni Tranidou, Antonios Siargkas, Emmanouela Magriplis, Ioannis Tsakiridis, Panagiota Kripouri, Aikaterini Apostolopoulou, Michail Chourdakis, Themistoklis Dagklis
Nutrients.2025; 17(11): 1917. CrossRef
Analyzing Protein and Glucose Levels in Pregnant Women Attending Antenatal Care at Health Centers in Port Harcourt, Rivers State
BIEBUMA Tamunoitekena Blessing, Aleruchi Owhonka, Egbono Frank Fubara
International Journal of Advanced Research in Science, Communication and Technology.2024; : 512. CrossRef
Association of Vegetables-Fruits Dietary Patterns with Gestational Diabetes Mellitus: Mediating Effects of Gut Microbiota
Xiaoxi Shan, Caixia Peng, Hanshuang Zou, Yunfeng Pan, Minchan Wu, Qingqing Xie, Qian Lin
Nutrients.2024; 16(14): 2300. CrossRef
Are Maternal Dietary Patterns During Pregnancy Associated with the Risk of Gestational Diabetes Mellitus? A Systematic Review of Observational Studies
Charikleia Kyrkou, Apostolos P. Athanasiadis, Michael Chourdakis, Stefania Kada, Costas G. Biliaderis, Georgios Menexes, Alexandra-Maria Michaelidou
Nutrients.2024; 16(21): 3632. CrossRef
Association Between the EAT-Lancet Reference Diet and Gestational Diabetes Mellitus: A Mini-Review
Niuniu Sun, Shubo Wen, Zhenyu Huo, Zitong He, Tongyao Sun, Jingxi Hu, Emily Sonestedt, Yan Borné, Shunming Zhang
Nutrients.2024; 16(23): 4073. CrossRef
Maternal dietary components in the development of gestational diabetes mellitus: a systematic review of observational studies to timely promotion of health
Victoria Lambert, Sonia Edith Muñoz, Carla Gil, María Dolores Román
Nutrition Journal.2023;[Epub] CrossRef
Fruit, vegetable, and fruit juice consumption and risk of gestational diabetes mellitus: a systematic review and meta-analysis
Yan-Ping Liao, Qing-Xiang Zheng, Xiu-Min Jiang, Xiao-Qian Chen, Xiao-Xia Gao, Yu-Qing Pan
Nutrition Journal.2023;[Epub] CrossRef
The effects of plant-based dietary patterns on the risk of developing gestational diabetes mellitus: A systematic review and meta-analysis
Yu Zhu, QingXiang Zheng, Ling Huang, XiuMin Jiang, XiaoXia Gao, JiaNing Li, RuLin Liu, Kent Lai
PLOS ONE.2023; 18(10): e0291732. CrossRef
Molecular pathways and nutrigenomic review of insulin resistance development in gestational diabetes mellitus
Patricia Guevara-Ramírez, Elius Paz-Cruz, Santiago Cadena-Ullauri, Viviana A. Ruiz-Pozo, Rafael Tamayo-Trujillo, Maria L. Felix, Daniel Simancas-Racines, Ana Karina Zambrano
Frontiers in Nutrition.2023;[Epub] CrossRef
Effectiveness of pre-pregnancy lifestyle in preventing gestational diabetes mellitus—a systematic review and meta-analysis of 257,876 pregnancies
Swetha Sampathkumar, Durga Parkhi, Yonas Ghebremichael-Weldeselassie, Nithya Sukumar, Ponnusamy Saravanan
Nutrition & Diabetes.2023;[Epub] CrossRef
Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies
Elaine Luiza Santos Soares de Mendonça, Marilene Brandão Tenório Fragoso, Jerusa Maria de Oliveira, Jadriane Almeida Xavier, Marília Oliveira Fonseca Goulart, Alane Cabral Menezes de Oliveira
Antioxidants.2022; 11(1): 129. CrossRef
Ferulic acid targets ACSL1 to ameliorate lipid metabolic disorders in db/db mice
Jie Gao, Xue Gu, Manqian Zhang, Xingwang Zu, Fukui Shen, Xiaotao Hou, Erwei Hao, Gang Bai
Journal of Functional Foods.2022; 91: 105009. CrossRef
Effect of dietary pattern on pregnant women with gestational diabetes mellitus and its clinical significance
Jianping Wang, Zuoliang Xie, Peipei Chen, Yuhuan Wang, Baoqing Li, Fen Dai
Open Life Sciences.2022; 17(1): 202. CrossRef
Dietary Protein Patterns during Pregnancy Are Associated with Risk of Gestational Diabetes Mellitus in Chinese Pregnant Women
Weijia Wu, Nu Tang, Jingjing Zeng, Jin Jing, Li Cai
Nutrients.2022; 14(8): 1623. CrossRef
Dietary Acid Load Is Positively Associated With Risk of Gestational Diabetes Mellitus in a Prospective Cohort of Chinese Pregnant Women
Rui Zhao, Leilei Zhou, Gang Lei, Shanshan Wang, Yan Li, Xuefeng Yang, Guoping Xiong, Liping Hao
Frontiers in Nutrition.2022;[Epub] CrossRef

First
Prev
Page of 3
Next
Last

Search