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Metabolic Risk/Epidemiology
One-Carbon Metabolism Nutrients, Genetic Variation, and Diabetes Mellitus
Jie Zhu, Gunjana Saikia, Xiaotao Zhang, Xiaoxi Shen, Ka Kahe
Diabetes Metab J. 2024;48(2):170-183.   Published online March 12, 2024
DOI: https://doi.org/10.4093/dmj.2023.0272
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Diabetes mellitus (DM) affects about 9.3% of the population globally. Hyperhomocysteinemia (HHcy) has been implicated in the pathogenesis of DM, owing to its promotion of oxidative stress, β-cell dysfunction, and insulin resistance. HHcy can result from low status of one-carbon metabolism (OCM) nutrients (e.g., folate, choline, betaine, vitamin B6, B12), which work together to degrade homocysteine by methylation. The etiology of HHcy may also involve genetic variation encoding key enzymes in OCM. This review aimed to provide an overview of the existing literature assessing the link between OCM nutrients status, related genetic factors, and incident DM. We also discussed possible mechanisms underlying the role of OCM in DM development and provided recommendations for future research and practice. Even though the available evidence remains inconsistent, some studies support the potential beneficial effects of intakes or blood levels of OCM nutrients on DM development. Moreover, certain variants in OCM-related genes may influence metabolic handling of methyl-donors and presumably incidental DM. Future studies are warranted to establish the causal inference between OCM and DM and examine the interaction of OCM nutrients and genetic factors with DM development, which will inform the personalized recommendations for OCM nutrients intakes on DM prevention.
Original Article
Basic Research
A New Concept in Antidiabetic Therapeutics: A Concerted Removal of Labile Iron and Intracellular Deposition of Zinc
Vladimir Vinokur, Eduard Berenshtein, Mordechai Chevion, Dror Chevion
Diabetes Metab J. 2024;48(1):59-71.   Published online January 3, 2024
DOI: https://doi.org/10.4093/dmj.2022.0292
Retraction in: Diabetes Metab J 2024;48(2):325
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Short Communication
Others
Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic Rats
Muruganantham Koothappan, Roshana Devi Vellai, Iyyam Pillai Subramanian, Sorimuthu Pillai Subramanian
Diabetes Metab J. 2018;42(3):244-248.   Published online April 24, 2018
DOI: https://doi.org/10.4093/dmj.2018.0002
  • 3,640 View
  • 49 Download
  • 4 Web of Science
  • 4 Crossref
AbstractAbstract PDFPubReader   

Due to the multifactorial and multisystemic nature of diabetes mellitus, it is often treated with a combination of therapeutic agents having different mode of action. Earlier, we have synthesized several organozinc complexes and evaluated their safety and antidiabetic properties in experimental type 2 diabetes mellitus (T2DM). More recently, we have synthesized a metformin-3-hydroxyflavone complex and studied its antidiabetic efficacy in experimental rats. In the present study, a new zinc-mixed ligand (metformin-3-hydroxyflavone) was synthesized, characterized by spectral studies and its antidiabetic properties was evaluated in HFD fed—low dose streptozotocin induced T2DM in rats. The hypoglycemic efficacy of the complex was evaluated through oral glucose tolerance test, homeostasis model assessment of insulin resistance, quantitative insulin sensitivity check index and by determining the status of important biochemical parameters. Oral administration of the complex at a concentration of 10 mg/kg body weight/rat/day for 30 days significantly improved the glucose homeostasis. The complex possesses significant antidiabetic properties relatively at a less concentration than metformin-3-hydroxyflavone complex in ameliorating hyperglycemia.

Citations

Citations to this article as recorded by  
  • Metformin compounds: A review on the importance and the possible applications
    A H Ismail, Z S Al-Garawi, K Al-Shamari, A T Salman
    Journal of Physics: Conference Series.2021; 1853(1): 012060.     CrossRef
  • A Review on Natural Products and Herbs Used in the Management of Diabetes
    Deepshikha Patle, Manish Vyas, Gopal L. Khatik
    Current Diabetes Reviews.2021; 17(2): 186.     CrossRef
  • The role of activation of KАTP channels on hydrogen sulfide induced renoprotective effect on diabetic nephropathy
    Eman A. Elbassuoni, Neven M. Аziz, Wagdу N. Habeeb
    Journal of Cellular Physiology.2020; 235(6): 5223.     CrossRef
  • A comprehensive review on zinc(II) complexes as anti-diabetic agents: The advances, scientific gaps and prospects
    Chika Ifeanyi Chukwuma, Samson S. Mashele, Kenneth C. Eze, Godfrey R. Matowane, Shahidul Md. Islam, Susanna L. Bonnet, Anwar E.M. Noreljaleel, Limpho M. Ramorobi
    Pharmacological Research.2020; 155: 104744.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal