Diabetes & Metabolism Journal

Review

Metabolic Risk/Epidemiology
One-Carbon Metabolism Nutrients, Genetic Variation, and Diabetes Mellitus: Jie Zhu, Gunjana Saikia, Xiaotao Zhang, Xiaoxi Shen, Ka Kahe; Diabetes Metab J. 2024;48(2):170-183. Published online March 12, 2024; DOI: https://doi.org/10.4093/dmj.2023.0272

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Abstract PDF Supplementary Material PubReader ePub

Diabetes mellitus (DM) affects about 9.3% of the population globally. Hyperhomocysteinemia (HHcy) has been implicated in the pathogenesis of DM, owing to its promotion of oxidative stress, β-cell dysfunction, and insulin resistance. HHcy can result from low status of one-carbon metabolism (OCM) nutrients (e.g., folate, choline, betaine, vitamin B6, B12), which work together to degrade homocysteine by methylation. The etiology of HHcy may also involve genetic variation encoding key enzymes in OCM. This review aimed to provide an overview of the existing literature assessing the link between OCM nutrients status, related genetic factors, and incident DM. We also discussed possible mechanisms underlying the role of OCM in DM development and provided recommendations for future research and practice. Even though the available evidence remains inconsistent, some studies support the potential beneficial effects of intakes or blood levels of OCM nutrients on DM development. Moreover, certain variants in OCM-related genes may influence metabolic handling of methyl-donors and presumably incidental DM. Future studies are warranted to establish the causal inference between OCM and DM and examine the interaction of OCM nutrients and genetic factors with DM development, which will inform the personalized recommendations for OCM nutrients intakes on DM prevention.

Citations

Citations to this article as recorded by

Alterations in Choline Metabolism in Non-Obese Individuals with Insulin Resistance and Type 2 Diabetes Mellitus
Haya Al-Sulaiti, Najeha Anwardeen, Sara S. Bashraheel, Khaled Naja, Mohamed A. Elrayess
Metabolites.2024; 14(8): 457. CrossRef
Association between oxidative balance score and diabetic kidney disease, low estimated glomerular filtration rate and albuminuria in type 2 diabetes mellitus patients: a cross-sectional study
Cong Liu, Jiju Yang, Hongdian Li, Yuanyuan Deng, Pengfei He, Jiao Zhang, Mianzhi Zhang
Frontiers in Endocrinology.2024;[Epub] CrossRef

Original Article

Basic Research
A New Concept in Antidiabetic Therapeutics: A Concerted Removal of Labile Iron and Intracellular Deposition of Zinc: Vladimir Vinokur, Eduard Berenshtein, Mordechai Chevion, Dror Chevion; Diabetes Metab J. 2024;48(1):59-71. Published online January 3, 2024; DOI: https://doi.org/10.4093/dmj.2022.0292; Retraction in: Diabetes Metab J 2024;48(2):325

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Short Communication

Others
Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic Rats: Muruganantham Koothappan, Roshana Devi Vellai, Iyyam Pillai Subramanian, Sorimuthu Pillai Subramanian; Diabetes Metab J. 2018;42(3):244-248. Published online April 24, 2018; DOI: https://doi.org/10.4093/dmj.2018.0002

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Abstract PDF PubReader

Due to the multifactorial and multisystemic nature of diabetes mellitus, it is often treated with a combination of therapeutic agents having different mode of action. Earlier, we have synthesized several organozinc complexes and evaluated their safety and antidiabetic properties in experimental type 2 diabetes mellitus (T2DM). More recently, we have synthesized a metformin-3-hydroxyflavone complex and studied its antidiabetic efficacy in experimental rats. In the present study, a new zinc-mixed ligand (metformin-3-hydroxyflavone) was synthesized, characterized by spectral studies and its antidiabetic properties was evaluated in HFD fed—low dose streptozotocin induced T2DM in rats. The hypoglycemic efficacy of the complex was evaluated through oral glucose tolerance test, homeostasis model assessment of insulin resistance, quantitative insulin sensitivity check index and by determining the status of important biochemical parameters. Oral administration of the complex at a concentration of 10 mg/kg body weight/rat/day for 30 days significantly improved the glucose homeostasis. The complex possesses significant antidiabetic properties relatively at a less concentration than metformin-3-hydroxyflavone complex in ameliorating hyperglycemia.

Citations

Citations to this article as recorded by

Metformin compounds: A review on the importance and the possible applications
A H Ismail, Z S Al-Garawi, K Al-Shamari, A T Salman
Journal of Physics: Conference Series.2021; 1853(1): 012060. CrossRef
A Review on Natural Products and Herbs Used in the Management of Diabetes
Deepshikha Patle, Manish Vyas, Gopal L. Khatik
Current Diabetes Reviews.2021; 17(2): 186. CrossRef
The role of activation of KАTP channels on hydrogen sulfide induced renoprotective effect on diabetic nephropathy
Eman A. Elbassuoni, Neven M. Аziz, Wagdу N. Habeeb
Journal of Cellular Physiology.2020; 235(6): 5223. CrossRef
A comprehensive review on zinc(II) complexes as anti-diabetic agents: The advances, scientific gaps and prospects
Chika Ifeanyi Chukwuma, Samson S. Mashele, Kenneth C. Eze, Godfrey R. Matowane, Shahidul Md. Islam, Susanna L. Bonnet, Anwar E.M. Noreljaleel, Limpho M. Ramorobi
Pharmacological Research.2020; 155: 104744. CrossRef

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