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Diabetes Metab J : Diabetes & Metabolism Journal



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Serum 25-Hydroxyvitamin D Concentration Is Independently Inversely Associated with Insulin Resistance in the Healthy, Non-Obese Korean Population
So Young Ock, Kyoung Hwa Ha, Bu Kyung Kim, Hyeon Chang Kim, Jee-Seon Shim, Myung Ha Lee, Young Me Yoon, Dae Jung Kim
Diabetes Metab J. 2016;40(5):367-375.   Published online July 26, 2016
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  • 31 Download
  • 9 Web of Science
  • 9 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   

We evaluated the associations between 25-hydroxyvitamin D (25(OH)D) concentrations in serum and insulin resistance in the healthy Korean population.


We conducted this cross-sectional analysis in 1,807 healthy Korean people (628 men and 1,179 women) aged 30 to 64 years in the Cardiovascular and Metabolic Disease Etiologic Research Center study. All participants were assessed for 25(OH)D, fasting glucose, and insulin levels, and completed a health examination and lifestyle questionnaire according to standard procedures. Insulin resistance was defined as the homeostasis model assessment insulin resistance higher than the 75 percentile.


Compared to those in the highest tertile (≥14.3 ng/mL), the odds ratio (OR) for insulin resistance was 1.37 (95% confidence interval [CI], 1.01 to 1.86) for the 1st tertile (<9.7 ng/mL) and 1.19 (95% CI, 0.08 to 1.62) for the 2nd tertile (9.7 to 14.3 ng/mL) after adjusting for age, gender, waist circumference, alcohol consumption, smoking status, physical exercise, season, and cohort. After stratification of the subjects by adiposity, these associations remained only in non-obese subjects (lowest tertile vs. highest tertile, multivariable OR, 1.64; 95% CI, 1.05 to 2.56).


Serum 25(OH)D has an independent inverse association with insulin resistance in the healthy, non-obese Korean population, even among people with vitamin D insufficiency.


Citations to this article as recorded by  
  • Vitamin D and Cardiovascular Diseases: An Update
    Farrookh Haider, Hashsaam Ghafoor, Omar F Hassan, Khalid Farooqui, Ali O. Mohamed Bel Khair, Faryal Shoaib
    Cureus.2023;[Epub]     CrossRef
  • Vitamin D as predictor Marker of kidney disease in males with type 2 diabetes mellitus
    Abeer J. Hassan, Sarmad Ajeel Hazzaa, Dunya Najim Alden Ahmed
    Bionatura.2022; 7(2): 1.     CrossRef
  • Vitamin D Effect on Ultrasonography and Laboratory Indices and Biochemical Indicators in the Blood: an Interventional Study on 12 to 18-Year-Old Children with Fatty Liver
    Kokab Namakin, Mahya Hosseini, Mahmoud Zardast, Mahyar Mohammadifard
    Pediatric Gastroenterology, Hepatology & Nutrition.2021; 24(2): 187.     CrossRef
  • The Association between Vitamin D and Nonalcoholic Fatty Liver Disease Assessed by Controlled Attenuation Parameter
    Nam Ju Heo, Hyo Eun Park, Ji Won Yoon, Min-Sun Kwak, Jong In Yang, Su Jin Chung, Jeong Yoon Yim, Goh Eun Chung
    Journal of Clinical Medicine.2021; 10(12): 2611.     CrossRef
  • Association between serum 25-hydroxy vitamin D level and metabolic associated fatty liver disease (MAFLD)—a population-based study
    Bo Wan, Yuan Gao, Yushan Zheng, Ruanqin Chen
    Endocrine Journal.2021; 68(6): 631.     CrossRef
  • Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience
    Vincenzo Pilone, Salvatore Tramontano, Carmen Cutolo, Federica Marchese, Antonio Maria Pagano, Federica Di Spirito, Luigi Schiavo
    International Journal for Vitamin and Nutrition Research.2020; 90(3-4): 346.     CrossRef
  • Cohort Profile: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort in Korea
    Jee-Seon Shim, Bo Mi Song, Jung Hyun Lee, Seung Won Lee, Ji Hye Park, Dong Phil Choi, Myung Ha Lee, Kyoung Hwa Ha, Dae Jung Kim, Sungha Park, Won-Woo Lee, Yoosik Youm, Eui-Cheol Shin, Hyeon Chang Kim
    Yonsei Medical Journal.2019; 60(8): 804.     CrossRef
  • Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort: study protocol and results of the first 3 years of enrollment
    Jee-Seon Shim, Bo Mi Song, Jung Hyun Lee, Seung Won Lee, Ji Hye Park, Dong Phil Choi, Myung Ha Lee, Kyoung Hwa Ha, Dae Jung Kim, Sungha Park, Won-Woo Lee, Hyeon Chang Kim
    Epidemiology and Health.2017; 39: e2017016.     CrossRef
  • Vitamin D and coronary atherosclerosis
    Dae Jung Kim
    Osteoporosis and Sarcopenia.2017; 3(4): 201.     CrossRef
Effects of Vitamin D and Calcium Intervention on the Improvement of Resistance in Patients with Type 2 Diabetes Mellitus.
Young Mee Choi, Jun Ho Lee, Ji Sook Han
Korean Diabetes J. 2009;33(4):324-334.   Published online August 1, 2009
  • 2,399 View
  • 41 Download
  • 6 Crossref
AbstractAbstract PDF
Recent reports suggest that the intake of vitamin D and calcium may influence insulin resistance. The aim of this study was to assess the effects of vitamin D and calcium intervention on the improvement of blood glucose and insulin resistance in patients with type 2 diabetes mellitus (DM). METHODS: Fasting blood glucose, glycosylated hemoglobin A1c (HbA1C), serum 25(OH)D3, serum lipid levels, insulin secretion, and activity and dietary surveys were analyzed in type 2 DM patients both before and after a 12-week vitamin D and calcium intake intervention. RESULTS: The serum 25(OH)D3 level was found to be negatively correlated with insulin resistance and fasting blood glucose. Calcium intake level was also negatively correlated with insulin resistance. Fasting blood glucose, HbA1C, and HOMA-IR decreased significantly (P <0.05) following vitamin D and calcium intake intervention in the medical nutrition therapy (MNT) group, while there was no such change observed in the control group. Dietary calcium and vitamin D intakes were significantly (P <0.05) higher in the MNT group than in the control group. The concentrations of serum 25(OH)D3 and insulin secretion increased slightly in the MNT group following the 12-week intervention; however, these results did not reach statistical significance. CONCLUSION: The results of the present study indicate that calcium and vitamin D intervention may be helpful in improving fasting blood glucose, HbA1C, serum 25(OH)D3 and HOMA-IR in patients with type 2 DM who have insufficient serum 25(OH)D3 concentrations.


Citations to this article as recorded by  
  • Comparison of Biological Markers and Lifestyle Factors on the Presence of Diabetes Mellitus in Middle-aged adults
    Hye-Sun Keum, Soon-Rim Suh
    Journal of the Korea Academia-Industrial cooperation Society.2016; 17(2): 104.     CrossRef
  • A prospective randomized controlled trial of the effects of vitamin D supplementation on long-term glycemic control in type 2 diabetes mellitus of Korea
    Ohk-Hyun Ryu, Sungwha Lee, Jaemyung Yu, Moon-Gi Choi, Hyung Joon Yoo, Franco Mantero
    Endocrine Journal.2014; 61(2): 167.     CrossRef
  • A Study of Snack Consumption, Night-Eating Habits, and Nutrient Intake in Gestational Diabetes Mellitus
    Hee-jin Park, JinJu Lee, Ji-Myung Kim, Hyun Ah Lee, Sung-Hoon Kim, Yuri Kim
    Clinical Nutrition Research.2013; 2(1): 42.     CrossRef
  • Vitamin D and Diabetes
    Dallae Ju
    Journal of Korean Diabetes.2011; 12(2): 104.     CrossRef
  • Nutrients and Dish Intake by Fasting Blood Glucose Level
    Jihyun Choi, Hyun-Kyung Moon
    The Korean Journal of Nutrition.2010; 43(5): 463.     CrossRef
  • Vitamin D and Diabetes Mellitus
    Jung Hyun Noh
    Korean Diabetes Journal.2009; 33(4): 276.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal