Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
128 "Type 2 Diabetes"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Articles
Others
Effect of Atorvastatin on Growth Differentiation Factor-15 in Patients with Type 2 Diabetes Mellitus and Dyslipidemia
Ji Min Kim, Min Kyung Back, Hyon-Seung Yi, Kyong Hye Joung, Hyun Jin Kim, Bon Jeong Ku
Diabetes Metab J. 2016;40(1):70-78.   Published online February 19, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.70
  • 4,859 View
  • 50 Download
  • 5 Web of Science
  • 5 Crossref
AbstractAbstract PDFPubReader   
Background

Elevated serum levels of growth differentiation factor-15 (GDF-15) are associated with type 2 diabetes. Therefore, the effects of atorvastatin on metabolic parameters and GDF-15 levels in patients with type 2 diabetes and dyslipidemia were evaluated.

Methods

In this prospective randomized trial from February 2013 to March 2014, 50 consecutive type 2 diabetic patients with a low density lipoprotein cholesterol (LDL-C) levels ≥100 mg/dL were enrolled. The patients were divided into two groups based on the amount of atorvastatin prescribed, 10 mg/day (n=23) or 40 mg/day (n=27). The effect of atorvastatin on metabolic parameters, including lipid profiles and GDF-15 levels, at baseline and after 8 weeks of treatment were compared.

Results

The baseline metabolic parameters and GDF-15 levels were not significantly different between the two groups. After 8 weeks of treatment, the total cholesterol (TC) and LDL-C levels were significantly decreased in both groups. The mean changes in TC and LDL-C levels were more significant in the 40 mg atorvastatin group. The GDF-15 level was decreased in the 10 mg atorvastatin group, from 1,460.6±874.8 to 1,451.0±770.8 pg/mL, and was increased in the 40 mg atorvastatin group, from 1,271.6±801.0 to 1,341.4±855.2 pg/mL. However, the change in the GDF-15 level was not statistically significant in the 10 or 40 mg atorvastatin group (P=0.665 and P=0.745, respectively).

Conclusion

The GDF-15 levels were not significantly changed after an 8-week treatment with atorvastatin in type 2 diabetic patients.

Citations

Citations to this article as recorded by  
  • The relationship of Growth differentiation factor-15 with renal damage and dyslipidemia in non-albuminuric and albuminuric Type-2 Diabetes Mellitus
    Hasan Esat Yücel, Bilal İlanbey
    Medical Science and Discovery.2022; 9(6): 334.     CrossRef
  • Comparative effectiveness of statins on non-high density lipoprotein cholesterol in people with diabetes and at risk of cardiovascular disease: systematic review and network meta-analysis
    Alexander Hodkinson, Dialechti Tsimpida, Evangelos Kontopantelis, Martin K Rutter, Mamas A Mamas, Maria Panagioti
    BMJ.2022; : e067731.     CrossRef
  • The Cytokine Growth Differentiation Factor-15 and Skeletal Muscle Health: Portrait of an Emerging Widely Applicable Disease Biomarker
    Boel De Paepe
    International Journal of Molecular Sciences.2022; 23(21): 13180.     CrossRef
  • Biomarkers of subclinical atherosclerosis in patients with psoriasis
    Hannah Kaiser, Xing Wang, Amanda Kvist-Hansen, Martin Krakauer, Peter Michael Gørtz, Benjamin D. McCauley, Lone Skov, Christine Becker, Peter Riis Hansen
    Scientific Reports.2021;[Epub]     CrossRef
  • Growth differentiation factor-15 regulates oxLDL-induced lipid homeostasis and autophagy in human macrophages
    Kathrin Ackermann, Gabriel A. Bonaterra, Ralf Kinscherf, Anja Schwarz
    Atherosclerosis.2019; 281: 128.     CrossRef
Maternal and Neonatal Outcomes in Korean Women with Type 1 and Type 2 Diabetes
Hee-Sook Kim, Hye-Jung Jang, Jeong-Eun Park, Moon-Young Kim, Sun-Young Ko, Sung-Hoon Kim
Diabetes Metab J. 2015;39(4):316-320.   Published online August 17, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.4.316
  • 3,947 View
  • 39 Download
  • 5 Web of Science
  • 5 Crossref
AbstractAbstract PDFPubReader   
Background

The purpose of this study was to evaluate maternal and neonatal outcomes in Korean women with type 1 diabetes and type 2 diabetes.

Methods

We performed a retrospective survey of 163 pregnancies in women with type 1 diabetes (n=13) and type 2 diabetes (n=150) treated from 2003 to 2010 at Cheil General Hospital & Women's Healthcare Center, Korea. We compared maternal characteristics as well as maternal and neonatal outcomes between groups.

Results

Differences in glycosylated hemoglobin between type 1 and type 2 diabetes were not significant. Birth weight (3,501±689.6 g vs. 3,366±531.4 g) and rate of major congenital malformations (7.7% vs. 5.6%) were not significantly different. However, women with type 1 diabetes had higher rates of preeclampsia (38.5% vs. 8.2%, P=0.006), large for gestational age (LGA; 46.2% vs. 20.4%, P=0.004), macrosomia (38.5% vs. 13.4%, P=0.032), and admission for neonatal care (41.7% vs. 14.8%, P=0.03) than women with type 2 diabetes.

Conclusion

Maternal and neonatal outcomes for women with type 1 diabetes were poorer than for women with type 2 diabetes, especially preeclampsia, LGA, macrosomia and admission to the neonatal intensive care unit.

Citations

Citations to this article as recorded by  
  • The Impact of Type 2 Diabetes on Women’s Health and Well-being During Their Reproductive Years: A Mixed-methods Systematic Review
    Aycan Celik, Rita Forde, Simona Racaru, Angus Forbes, Jackie Sturt
    Current Diabetes Reviews.2022;[Epub]     CrossRef
  • Application of the electronic nose in predicting preeclampsia in high-risk pregnancies. Pilot study
    Karen Beatriz Méndez Rodríguez, Luis Manuel Ramírez Gómez, Leticia Carrizales Yáñez, Rogelio Flores Ramírez, Omar Ornelas-Rebolledo, Jaime Antonio Borjas-García, Francisco Pérez-Vázquez, Maribel Rodríguez Aguilar
    Archives of Medical Research.2021;[Epub]     CrossRef
  • Obstetric and neonatal complications among women with autoimmune disease
    Andrew Williams, Katherine Grantz, Indulaxmi Seeni, Candace Robledo, Shanshan Li, Marion Ouidir, Carrie Nobles, Pauline Mendola
    Journal of Autoimmunity.2019; 103: 102287.     CrossRef
  • Effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus
    Adel T. Abu-Heija, Majeda R. Al-Bash, Moza A. Al-Kalbani
    Journal of Taibah University Medical Sciences.2017; 12(4): 338.     CrossRef
  • Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI
    Nicolás Santander, Carlos Lizama, María José Parga, Alonso Quiroz, Druso Pérez, Guadalupe Echeverría, Lorena Ulloa, Verónica Palma, Attilio Rigotti, Dolores Busso
    Scientific Reports.2017;[Epub]     CrossRef
Myeloperoxidase Is Associated with Insulin Resistance and Inflammation in Overweight Subjects with First-Degree Relatives with Type 2 Diabetes Mellitus
Anel Gómez García, Mireya Rivera Rodríguez, Carlos Gómez Alonso, Daysi Yazmin Rodríguez Ochoa, Cleto Alvarez Aguilar
Diabetes Metab J. 2015;39(1):59-65.   Published online February 16, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.1.59
  • 5,200 View
  • 50 Download
  • 38 Web of Science
  • 35 Crossref
AbstractAbstract PDFPubReader   
Background

Family history of type 2 diabetes mellitus (T2DM) is one of risk factors for that in future a subject can develop diabetes. Insulin resistance (IR) is important in the pathogenesis of T2DM. There is evidence that oxidative stress plays an important role in the etiology and/or progression of diabetes. Myeloperoxidase (MPO) participates in developing of inflammation. The objective was to investigate if MPO is associated with IR and inflammation in individuals with first-degree relatives of T2DM.

Methods

Cross-sectional study in 84 overweight individuals with family history of T2DM divided in two groups according to IR, group with IR (homeostasis model assessment [HOMA] ≥2.5; n=43) and control group (CG; HOMA <2.5; n=41). Complete clinical history and a venous blood sample were collected for measuring glucose and lipids profile, insulin, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), MPO, glutathione reductase (GRd), glutathione peroxidase, and superoxide dismutase.

Results

MPO, TNF-α, and IL-6 were higher in patients with IR than in CG (MPO: 308.35 [190.85 to 445.42] vs. 177.35 [104.50 to 279.85], P=0.0001; TNF-α: 13.46 [10.58 to 18.88] vs. 9.39 [7.53 to 11.25], P=0.0001; IL-6: 32.93 [24.93 to 38.27] vs. 15.60 [12.93 to 26.27]; P=0.0001, respectively). MPO was associated with IR (rho de Spearman=0.362, P=0.001). In the analysis of lineal regression, MPO predicts IR (β, 0.263; t, 2.520; P=0.014). In the univariate analysis, MPO had an odds ratio of 9.880 for risk of IR (95% confidence interval, 2.647 to 36.879).

Conclusion

MPO had relation with IR and inflammation parameters in overweight subjects with first-degree relatives of T2DM. We need studies on a casual relationship and molecular mechanisms among the increased serum MPO levels, inflammation markers, and IR.

Citations

Citations to this article as recorded by  
  • Free Radical Lipid Peroxidation Induced by Reactive Halogen Species
    Oleg M. Panasenko, Yury A. Vladimirov, Valery I. Sergienko
    Biochemistry (Moscow).2024; 89(S1): S148.     CrossRef
  • Relationship Between Serum Levels of Oxidized Lipoproteins, Circulating Levels of Myeloperoxidase and Paraoxonase 1, and Diet in Young Subjects with Insulin Resistance
    Yaquelin Marchán-Figueroa, Brenda Tepec-Casarrubias, Ulises de la Cruz-Mosso, Constanza Cecilia Astudillo-López, Inés Matia-García, Lorenzo Salgado-Goytia, Mónica Espinoza-Rojo, Natividad Castro-Alarcón, Eugenia Flores-Alfaro, Isela Parra-Rojas
    Nutrients.2024; 16(22): 3930.     CrossRef
  • Serum levels of the novel adipokine isthmin-1 are associated with obesity in pubertal boys
    Francisco Javier Ruiz-Ojeda, Augusto Anguita-Ruiz, Maria C. Rico, Rosaura Leis, Gloria Bueno, Luis A. Moreno, Mercedes Gil-Campos, Ángel Gil, Concepción M. Aguilera
    World Journal of Pediatrics.2023; 19(9): 864.     CrossRef
  • Role of Innate Immune Cells in Chronic Diabetic Wounds
    Jayashree Vijaya Raghavan, Siddharth Jhunjhunwala
    Journal of the Indian Institute of Science.2023; 103(1): 249.     CrossRef
  • Serum Levels of Proinflammatory Biomarkers in Military Recruits with and without Metabolic Syndrome
    Abdulrahman K. Al Asmari, Hamoud A. Al Shehri, Haseeb A. Khan, Saud Al Omani, Saeed G. Kadasah, Ghaleb B. Horaib, Ahmed Al Buraidi, Abdullah A. Al Sharif, Fayez S. Mohammed, Rajamohamed Abbasmanthiri, Nasreddien M. Osman, Amilia Aminuddin
    Mediators of Inflammation.2023; 2023: 1.     CrossRef
  • Salivary Alterations of Myeloperoxidase in Patients with Systemic Diseases: A Systematic Review
    Kacper Nijakowski, Jakub Jankowski, Dawid Gruszczyński, Anna Surdacka
    International Journal of Molecular Sciences.2023; 24(15): 12078.     CrossRef
  • Established and potential cardiovascular risk factors in metabolic syndrome: Effect of bariatric surgery
    Bilal Bashir, Safwaan Adam, Jan H. Ho, Zara Linn, Paul N. Durrington, Handrean Soran
    Current Opinion in Lipidology.2023; 34(5): 221.     CrossRef
  • Sleeve Gastrectomy Provides Cardioprotection from Oxidative Stress In Vitro Due to Reduction of Circulating Myeloperoxidase
    Matthew Barron, Hailey Hayes, Zachary Bice, Kirkwood Pritchard, Tammy Lyn Kindel
    Nutrients.2023; 15(22): 4776.     CrossRef
  • Association of Plasma Myeloperoxidase with Inflammation and Diabetic status in HFpEF
    Sibille Lejeune, Audrey Ginion, Nassiba Menghoum, David Vancraeynest, Agnes Pasquet, Bernhard L. Gerber, Sandrine Horman, Christophe Beauloye, Anne-Catherine Pouleur
    Reviews in Cardiovascular Medicine.2023;[Epub]     CrossRef
  • Functional annotation and enrichment analysis of differentially expressed serum proteins in patients with type 2 diabetes after dapagliflozin
    Yan-Xue Zhao, Sarul Borjigin, Zhao-Li Yan
    World Journal of Diabetes.2022; 13(3): 224.     CrossRef
  • Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies
    Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Celia Andrés Juan, Francisco J. Plou, Eduardo Pérez-Lebeña
    International Journal of Molecular Sciences.2022; 23(18): 10735.     CrossRef
  • Non-Canonical Functions of Myeloperoxidase in Immune Regulation, Tissue Inflammation and Cancer
    Joey S. Lockhart, Ronen Sumagin
    International Journal of Molecular Sciences.2022; 23(20): 12250.     CrossRef
  • Taurine supplementation reduces myeloperoxidase and matrix-metalloproteinase-9 levels and improves the effects of exercise in cognition and physical fitness in older women
    Matheus Uba Chupel, Luciele Guerra Minuzzi, Guilherme Eustáquio Furtado, Mário Leonardo Santos, José Pedro Ferreira, Edith Filaire, Ana Maria Teixeira
    Amino Acids.2021; 53(3): 333.     CrossRef
  • Increased concentrations of myeloperoxidase in serum and serum extracellular vesicles are associated with type 2 diabetes mellitus
    Lu Peng, Xinwei Li, Yu Li, Wen Zhao, Shaoping Nie, Huahui Yu, Yue Qi, Yanwen Qin, Huina Zhang
    Clinica Chimica Acta.2021; 522: 70.     CrossRef
  • Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males
    Maria Apostolopoulou, Lucia Mastrototaro, Sonja Hartwig, Dominik Pesta, Klaus Straßburger, Elisabetta de Filippo, Tomas Jelenik, Yanislava Karusheva, Sofiya Gancheva, Daniel Markgraf, Christian Herder, K. Sreekumaran Nair, Andreas S. Reichert, Stefan Lehr
    Science Advances.2021;[Epub]     CrossRef
  • Increased Oxidative Stress in Gastric Cancer Patients and Their First‐Degree Relatives: A Prospective Study from Northeastern Brazil
    Manuel B. Braga-Neto, Deiziane V. S. Costa, Dulciene M. M. Queiroz, Felipe S. Maciel, Michelle S. de Oliveira, Antônio B. Viana-Junior, Flávia A. Santos, Renata F. C. Leitao, Gerly A. C. Brito, Paulo R. L. Vasconcelos, Lucia L. B. C. Braga, Ilaria Peluso
    Oxidative Medicine and Cellular Longevity.2021;[Epub]     CrossRef
  • Dysfunctional High-density Lipoprotein: The Role of Myeloperoxidase and Paraoxonase-1
    Tiziana Bacchetti, Gianna Ferretti, Federico Carbone, Stefano Ministrini, Fabrizio Montecucco, Tannaz Jamialahmadi, Amirhossein Sahebkar
    Current Medicinal Chemistry.2021; 28(14): 2842.     CrossRef
  • Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes
    Mohammad G. Qaddoumi, Muath Alanbaei, Maha M. Hammad, Irina Al Khairi, Preethi Cherian, Arshad Channanath, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Mohamed Abu-Farha, Jehad Abubaker
    Scientific Reports.2020;[Epub]     CrossRef
  • The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System
    Gholamreza Daryabor, Mohamad Reza Atashzar, Dieter Kabelitz, Seppo Meri, Kurosh Kalantar
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease
    Michael J. Davies, Clare L. Hawkins
    Antioxidants & Redox Signaling.2020; 32(13): 957.     CrossRef
  • Joint Measurements of Leukocyte Elastase and Myeloperoxidase Promote Identification of the State of Neutrophils in Diabetic Patients
    Michael Alexandrovski, Soimita Suciu, Jakob Alexandrovski
    BioResearch Open Access.2020; 9(1): 190.     CrossRef
  • Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus
    Mokerroma Ferdous, Sonam C. R, Sonchita R. Mudi, Mohammad Ali, Shahana Jasmin, Mohammad Fariduddin, Sheikh M.K. Alam, M.I. Arslan, Subrata K. Biswas
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(2): 83.     CrossRef
  • Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation
    Sonia Baig, Muhammad Shabeer, Ehsan Parvaresh Rizi, Madhur Agarwal, Michelle H Lee, Delicia Shu Qin Ooi, Chelsea Chia, Nweni Aung, Geelyn Ng, Yvonne Teo, Vanna Chhay, Faidon Magkos, Antonio Vidal-Puig, Raymond C S Seet, Sue-Anne Toh
    BMJ Open Diabetes Research & Care.2020; 8(1): e000945.     CrossRef
  • Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling
    Arnold Piek, Debby P. Y. Koonen, Elisabeth-Maria Schouten, Eva L. Lindtstedt, Erik Michaëlsson, Rudolf A. de Boer, Herman H. W. Silljé
    Scientific Reports.2019;[Epub]     CrossRef
  • Significance of Myeloperoxidase in the Onset of Cardiovascular Disease among Obese Children and Adolescents
    Inas R El-Alameey, Hanaa H Ahmed, Rehab A Mahmoud, Sahar A. Kairy, Eman A Medany
    Biomedical and Pharmacology Journal.2019; 12(04): 1647.     CrossRef
  • Postprandial activation of leukocyte‐endothelium interaction by fatty acids in the visceral adipose tissue microcirculation
    Kyle J. Preston, Inna Rom, Christine Vrakas, Gavin Landesberg, Zienab Etwebi, Sanae Muraoka, Michael Autieri, Satoru Eguchi, Rosario Scalia
    The FASEB Journal.2019; 33(11): 11993.     CrossRef
  • Myeloperoxidase as cardiovascular risk marker in pre-pubertal preterm children?
    Denise O. Schoeps, Simone Holzer, Fabiola I. Suano-Souza, Sonia Hix, Fernando L.A. Fonseca, Roseli O.S. Sarni
    Nutrition, Metabolism and Cardiovascular Diseases.2019; 29(12): 1345.     CrossRef
  • Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects
    Mohammad Ali, Shahana Jasmin, Mohammad Fariduddin, Sheikh M. K. Alam, M. I. Arslan, Subrata K. Biswas
    Molecular Biology Reports.2018; 45(5): 1245.     CrossRef
  • Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque
    Tingfu Du, Shuaiyao Lu, Qinfang Jiang, Yun Li, Kaili Ma
    Journal of Diabetes Research.2017; 2017: 1.     CrossRef
  • Association of Interleukin-6 and Myeloperoxidase with Insulin Resistance in Impaired Fasting Glucose Subjects
    Ashish Agarwal, Anupama Hegde, Charu Yadav, Afzal Ahmad, Poornima Ajay Manjrekar, Rukmini Mysore Srikantiah
    Indian Journal of Clinical Biochemistry.2017; 32(1): 33.     CrossRef
  • Association Between Tumor Necrosis Factor-α and Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes: a Meta-Analysis
    Ze-Peng Mu, Yan-Gang Wang, Cheng-Qian Li, Wen-Shan Lv, Bin Wang, Zhao-Hai Jing, Xue-Jia Song, Yu Lun, Ming-Yue Qiu, Xiao-Long Ma
    Molecular Neurobiology.2017; 54(2): 983.     CrossRef
  • Bipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: A preliminary report
    Rodrigo B. Mansur, Lucas B. Rizzo, Camila M. Santos, Elson Asevedo, Graccielle R. Cunha, Mariane N. Noto, Mariana Pedrini, Maiara Zeni-Graiff, Eduardo S. Gouvea, Quirino Cordeiro, Eva Z. Reininghaus, Roger S. McIntyre, Elisa Brietzke
    Journal of Psychiatric Research.2016; 80: 38.     CrossRef
  • Inter‐relation between brain‐derived neurotrophic factor and antioxidant enzymes in bipolar disorder
    Rodrigo B Mansur, Camila M Santos, Lucas B Rizzo, Graccielle R Cunha, Elson Asevedo, Mariane N Noto, Mariana Pedrini, Maiara Zeni, Quirino Cordeiro, Roger S McIntyre, Elisa Brietzke
    Bipolar Disorders.2016; 18(5): 433.     CrossRef
  • A CONSORT-Compliant, Randomized, Double-Blind, Placebo-Controlled Pilot Trial of Purified Anthocyanin in Patients With Nonalcoholic Fatty Liver Disease
    Pei-Wen Zhang, Feng-Xia Chen, Di Li, Wen-Hua Ling, Hong-Hui Guo
    Medicine.2015; 94(20): e758.     CrossRef
  • Relationship between glycemic control and histochemical myeloperoxidase activity in neutrophils in patients with type 2 diabetes
    Mustafa Unubol, Irfan Yavasoglu, Firuzan Kacar, Engin Guney, Imran Kurt Omurlu, Mevlut Ture, Gurhan Kadikoylu, Zahit Bolaman
    Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef
Genome-Wide Association Study Identifies Two Novel Loci with Sex-Specific Effects for Type 2 Diabetes Mellitus and Glycemic Traits in a Korean Population
Min Jin Go, Joo-Yeon Hwang, Tae-Joon Park, Young Jin Kim, Ji Hee Oh, Yeon-Jung Kim, Bok-Ghee Han, Bong-Jo Kim
Diabetes Metab J. 2014;38(5):375-387.   Published online October 17, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.5.375
  • 6,427 View
  • 46 Download
  • 29 Web of Science
  • 26 Crossref
AbstractAbstract PDFPubReader   
Background

Until recently, genome-wide association study (GWAS)-based findings have provided a substantial genetic contribution to type 2 diabetes mellitus (T2DM) or related glycemic traits. However, identification of allelic heterogeneity and population-specific genetic variants under consideration of potential confounding factors will be very valuable for clinical applicability. To identify novel susceptibility loci for T2DM and glycemic traits, we performed a two-stage genetic association study in a Korean population.

Methods

We performed a logistic analysis for T2DM, and the first discovery GWAS was analyzed for 1,042 cases and 2,943 controls recruited from a population-based cohort (KARE, n=8,842). The second stage, de novo replication analysis, was performed in 1,216 cases and 1,352 controls selected from an independent population-based cohort (Health 2, n=8,500). A multiple linear regression analysis for glycemic traits was further performed in a total of 14,232 nondiabetic individuals consisting of 7,696 GWAS and 6,536 replication study participants. A meta-analysis was performed on the combined results using effect size and standard errors estimated for stage 1 and 2, respectively.

Results

A combined meta-analysis for T2DM identified two new (rs11065756 and rs2074356) loci reaching genome-wide significance in CCDC63 and C12orf51 on the 12q24 region. In addition, these variants were significantly associated with fasting plasma glucose and homeostasis model assessment of β-cell function. Interestingly, two independent single nucleotide polymorphisms were associated with sex-specific stratification in this study.

Conclusion

Our study showed a strong association between T2DM and glycemic traits. We further observed that two novel loci with multiple diverse effects were highly specific to males. Taken together, these findings may provide additional insights into the clinical assessment or subclassification of disease risk in a Korean population.

Citations

Citations to this article as recorded by  
  • Family history of type 2 diabetes and the risk of type 2 diabetes among young and middle‐aged adults
    Ken R. Smith, Huong Meeks, David Curtis, Barbara B. Brown, Kyle Kole, Lori Kowaleski‐Jones
    Chronic Diseases and Translational Medicine.2024;[Epub]     CrossRef
  • Relationship between HECTD4 gene variants, obesity, and coffee consumption
    Min-Jeong Kim, Hyun-Seok Jin, Yong-Bin Eom
    European Journal of Clinical Nutrition.2024;[Epub]     CrossRef
  • Interactions between Bitter Taste Receptor Gene Variants and Dietary Intake Are Associated with the Incidence of Type 2 Diabetes Mellitus in Middle-Aged and Older Korean Adults
    Kyung Won Lee, Dayeon Shin
    International Journal of Molecular Sciences.2023; 24(3): 2199.     CrossRef
  • Evaluating machine learning-powered classification algorithms which utilize variants in the GCKR gene to predict metabolic syndrome: Tehran Cardio-metabolic Genetics Study
    Mahdi Akbarzadeh, Nadia Alipour, Hamed Moheimani, Asieh Sadat Zahedi, Firoozeh Hosseini-Esfahani, Hossein Lanjanian, Fereidoun Azizi, Maryam S. Daneshpour
    Journal of Translational Medicine.2022;[Epub]     CrossRef
  • The potential effects of HECTD4 variants on fasting glucose and triglyceride levels in relation to prevalence of type 2 diabetes based on alcohol intake
    Yoo Jeong Lee, Hansongyi Lee, Han Byul Jang, Min-Gyu Yoo, Sumin Im, Soo Kyung Koo, Hye-Ja Lee
    Archives of Toxicology.2022; 96(9): 2487.     CrossRef
  • Impaired fasting glucose and development of chronic kidney disease in non-diabetic population: a Mendelian randomization study
    Hyoungnae Kim, Suyeon Park, Soon Hyo Kwon, Jin Seok Jeon, Dong Cheol Han, Hyunjin Noh
    BMJ Open Diabetes Research & Care.2020; 8(1): e001395.     CrossRef
  • Interactions of Habitual Coffee Consumption by Genetic Polymorphisms with the Risk of Prediabetes and Type 2 Diabetes Combined
    Taiyue Jin, Jiyoung Youn, An Na Kim, Moonil Kang, Kyunga Kim, Joohon Sung, Jung Eun Lee
    Nutrients.2020; 12(8): 2228.     CrossRef
  • Genetic predisposition in type 2 diabetes: A promising approach toward a personalized management of diabetes
    Mahmoud M. Sirdah, N. Scott Reading
    Clinical Genetics.2020; 98(6): 525.     CrossRef
  • Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with type 2 diabetes mellitus in Chinese Korean ethnicity population
    Kui-Chen Zhou, Hong-Wei Liu, Chen Wang, Yan-Jun Fu, Feng Jin
    Medicine.2019; 98(5): e14288.     CrossRef
  • Association of Fasting Glucose Level with Neutrophil-Lymphocyte Ratio Compared to Leukocyte Count and Serum C-Reactive Protein
    Jin-Kyu Kim, Ah-Young Lee, Jee-Hyun Kang, Byung-Yeon Yu, Seong-Ju Kim
    Korean Journal of Family Medicine.2018; 39(1): 42.     CrossRef
  • New Common and Rare Variants Influencing Metabolic Syndrome and Its Individual Components in a Korean Population
    Ho-Sun Lee, Yongkang Kim, Taesung Park
    Scientific Reports.2018;[Epub]     CrossRef
  • Association of genetic variants in RETN, NAMPT and ADIPOQ gene with glycemic, metabolic traits and diabetes risk in a Chinese population
    Qiang Zhou, Bo Chen, Tianxing Ji, Miaoshan Luo, Jiandong Luo
    Gene.2018; 642: 439.     CrossRef
  • Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China
    Yaying Cao, Tao Wang, Yiqun Wu, Juan Juan, Xueying Qin, Xun Tang, Tao Wu, Yonghua Hu
    International Journal of Molecular Sciences.2018; 19(4): 1011.     CrossRef
  • Type 2 Diabetes Genetic Variants and Risk of Diabetic Retinopathy
    Yong He Chong, Qiao Fan, Yih Chung Tham, Alfred Gan, Shu Pei Tan, Gavin Tan, Jie Jin Wang, Paul Mitchell, Tien Yin Wong, Ching-Yu Cheng
    Ophthalmology.2017; 124(3): 336.     CrossRef
  • Precision Nutrition: A Review of Personalized Nutritional Approaches for the Prevention and Management of Metabolic Syndrome
    Juan De Toro-Martín, Benoit Arsenault, Jean-Pierre Després, Marie-Claude Vohl
    Nutrients.2017; 9(8): 913.     CrossRef
  • 10-year trajectory of β-cell function and insulin sensitivity in the development of type 2 diabetes: a community-based prospective cohort study
    Jung Hun Ohn, Soo Heon Kwak, Young Min Cho, Soo Lim, Hak Chul Jang, Kyong Soo Park, Nam H Cho
    The Lancet Diabetes & Endocrinology.2016; 4(1): 27.     CrossRef
  • Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus
    Alexandra Kautzky-Willer, Jürgen Harreiter, Giovanni Pacini
    Endocrine Reviews.2016; 37(3): 278.     CrossRef
  • No Interaction with Alcohol Consumption, but Independent Effect of C12orf51 (HECTD4) on Type 2 Diabetes Mellitus in Korean Adults Aged 40-69 Years: The KoGES_Ansan and Ansung Study
    Jihye Kim, Bermseok Oh, Ji Eun Lim, Mi Kyung Kim, C. Mary Schooling
    PLOS ONE.2016; 11(2): e0149321.     CrossRef
  • Risk Prediction Using Genome-Wide Association Studies on Type 2 Diabetes
    Sungkyoung Choi, Sunghwan Bae, Taesung Park
    Genomics & Informatics.2016; 14(4): 138.     CrossRef
  • Analysis of multiple related phenotypes in genome-wide association studies
    Sohee Oh, Iksoo Huh, Seung Yeoun Lee, Taesung Park
    Journal of Bioinformatics and Computational Biology.2016; 14(05): 1644005.     CrossRef
  • Recent progress in genetic and epigenetic research on type 2 diabetes
    Soo Heon Kwak, Kyong Soo Park
    Experimental & Molecular Medicine.2016; 48(3): e220.     CrossRef
  • Statistical power considerations in genotype-based recall randomized controlled trials
    Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Dmitry Shungin, Azra Kurbasic, Erik Ingelsson, Ewan R. Pearson, Ashfaq Ali, Paul W. Franks
    Scientific Reports.2016;[Epub]     CrossRef
  • The role of vitamin D, obesity and physical exercise in regulation of glycemia in Type 2 Diabetes Mellitus patients
    Abdulbari Bener, Abdulla O.A.A. Al-Hamaq, Eda Merve Kurtulus, Waleed K. Abdullatef, Mahmoud Zirie
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2016; 10(4): 198.     CrossRef
  • Recent advances in understanding the genetic architecture of type 2 diabetes
    Karen L. Mohlke, Michael Boehnke
    Human Molecular Genetics.2015; 24(R1): R85.     CrossRef
  • Letter: Genome-Wide Association Study Identifies Two Novel Loci with Sex-Specific Effects for Type 2 Diabetes Mellitus and Glycemic Traits in a Korean Population (Diabetes Metab J2014;38:375-87)
    Soo Heon Kwak
    Diabetes & Metabolism Journal.2014; 38(6): 484.     CrossRef
  • Response: Genome-Wide Association Study Identifies Two Novel Loci with Sex-Specific Effects for Type 2 Diabetes Mellitus and Glycemic Traits in a Korean Population (Diabetes Metab J2014;38:375-87)
    Min Jin Go, Bong-Jo Kim
    Diabetes & Metabolism Journal.2014; 38(6): 487.     CrossRef
The Effects of Resistance Training on Muscle and Body Fat Mass and Muscle Strength in Type 2 Diabetic Women
Hwi Ryun Kwon, Kyung Ah Han, Yun Hyi Ku, Hee Jung Ahn, Bo-Kyung Koo, Ho Chul Kim, Kyung Wan Min
Korean Diabetes J. 2010;34(2):101-110.   Published online April 30, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.2.101
  • 6,212 View
  • 89 Download
  • 58 Crossref
AbstractAbstract PDFPubReader   
Background

Our goal was to investigate the effects of low intensity resistance training on body fat, muscle mass and strength, cardiovascular fitness, and insulin sensitivity in type 2 diabetes.

Methods

Twenty-eight overweight women with type 2 diabetes were randomly assigned to a resistance training group (RG, n = 13) or a control group (CG, n = 15). RG performed resistance training using elastic bands, of which strength was equal to 40 to 50% of one repetition maximum (1RM), for three days per week. Each exercise consisted of three sets for 60 minutes. We assessed abdominal fat using computed tomography, muscle mass using dual-energy X-ray absorptiometry, and muscle strength using Keiser's chest and leg press. Insulin sensitivity was measured using the insulin tolerance test, and aerobic capacity was expressed as oxygen uptake at the anaerobic threshold (AT-VO2) before and after the 12-week exercise program.

Results

The age of participants was 56.4 ± 7.1 years, duration of diabetes was 5.9 ± 5.5 years, and BMI was 27.4 ± 2.5 kg/m2, without significant differences between two groups. During intervention, a greater increase in muscle mass and greater decreases in both total fat mass and abdominal fat were observed in RG compared to those of CG (P = 0.015, P = 0.011, P = 0.010, respectively). Increase in 1RM of upper and lower extremities was observed in the RG (P = 0.004, P = 0.040, respectively), without changes in AT-VO2 and insulin resistance in either group.

Conclusion

In conclusion, the low intensity resistance training was effective in increasing muscle mass and strength and reducing total fat mass without change of insulin sensitivity in type 2 diabetic patients.

Citations

Citations to this article as recorded by  
  • Optimal strategies for exercise intervention in older people diabetic patients: The impacts of intensity, form, and frequency on glycemic control
    Xueru Yan, Yujuan Lu, Haoda Zhang, Chen Zhu, Lan Tian, Jishuai Chen, Enpeng He, Yingying Li
    Archives of Gerontology and Geriatrics.2025; 128: 105621.     CrossRef
  • The Impact of Resistance Exercise Training on Glycemic Control Among Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Yuwen Wan, Zhanguo Su
    Biological Research For Nursing.2024; 26(4): 597.     CrossRef
  • Effect of a home‐based physical activity program on metabolic syndrome in Ghanaian adults with type 2 diabetes: Protocol for a feasibility randomized controlled trial
    Mohammed Amin, Debra Kerr, Yacoba Atiase, Misbah Muhammad Samir, Andrea Driscoll
    Nursing Open.2024;[Epub]     CrossRef
  • The Effects of Exercise Interventions on Ectopic and Subcutaneous Fat in Patients with Type 2 Diabetes Mellitus: A Systematic Review, Meta-Analysis, and Meta-Regression
    Fatemeh Kazeminasab, Ali Bahrami Kerchi, Nasim Behzadnejad, Saba Belyani, Sara K. Rosenkranz, Reza Bagheri, Fred Dutheil
    Journal of Clinical Medicine.2024; 13(17): 5005.     CrossRef
  • Current trends in the development of soy-based foods containing probiotics and paving the path for soy-synbiotics
    Minnu Sasi, Sandeep Kumar, Muzaffar Hasan, Arpitha S. R., Enriqueta Garcia-Gutierrez, Sweta Kumari, Om Prakash, Lata Nain, Archana Sachdev, Anil Dahuja
    Critical Reviews in Food Science and Nutrition.2023; 63(29): 9995.     CrossRef
  • Communication Strategies and Resources for Health and Fitness Professionals to Minimize Diabetes-Related Social Stigma
    Lindsay J. Della, Annika Reitenga, Kristi M. King
    ACSM'S Health & Fitness Journal.2023; 27(2): 54.     CrossRef
  • IMPACTS OF MUSCLE TRAINING LOADS ON COLLEGE STUDENTS' PHYSICAL FITNESS
    Wang Lu, Zheng Hua, Wang Tailin, Wei Xuanxi
    Revista Brasileira de Medicina do Esporte.2023;[Epub]     CrossRef
  • Effect of resistance training on HbA1c in adults with type 2 diabetes mellitus and the moderating effect of changes in muscular strength: a systematic review and meta-analysis
    Anna K Jansson, Li X Chan, David R Lubans, Mitch J Duncan, Ronald C Plotnikoff
    BMJ Open Diabetes Research & Care.2022; 10(2): e002595.     CrossRef
  • Role of genetic factors (biology of telomeres) in cardiac rehabilitation
    D. M. Aronov, O. M. Drapkina, M. G. Bubnova
    Cardiovascular Therapy and Prevention.2022; 21(6): 3272.     CrossRef
  • Effects of 12-Week Progressive Sandbag Exercise Training on Glycemic Control and Muscle Strength in Patients with Type 2 Diabetes Mellitus Combined with Possible Sarcopenia
    Yu-Hsuan Chien, Chia-Jen Tsai, Dean-Chuan Wang, Pin-Hung Chuang, Hwai-Ting Lin
    International Journal of Environmental Research and Public Health.2022; 19(22): 15009.     CrossRef
  • Effects of Online Live Pilates Training during the COVID-19 Pandemic on Body Composition, Cardiovascular Function, and Physical Fitness in Sedentary Middle-aged Obese Women
    Jung-Heon Choi, Ko-Eun Choi, Man-Gyoon Lee
    Korean Journal of Sport Science.2022; 33(4): 521.     CrossRef
  • Muscular Strength, Functional Fitness, Body Composition, and Quality of Life after 12 Weeks of Detraining in Older Females
    Matúš Krčmár, Nora Halmová, Jaroslav Krajčovič, Bohumila Krčmárová
    Physical & Occupational Therapy In Geriatrics.2021; 39(2): 129.     CrossRef
  • Comparison between different types of exercise training in patients with type 2 diabetes mellitus: A systematic review and network metanalysis of randomized controlled trials
    Edoardo Mannucci, Allegra Bonifazi, Matteo Monami
    Nutrition, Metabolism and Cardiovascular Diseases.2021; 31(7): 1985.     CrossRef
  • DETERMINING NEW ANTHROPOMETRIC MARKERS FOR SCREENING TYPE 2 DM IN A CARIBBEAN REGION.
    Amruta Rajput, Upendra K Gupta, Guri Tzivion, Ravindrasingh Rajput
    INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2021; : 58.     CrossRef
  • Effect of elastic band resistance training with green coffee extract supplementation on adiposity indices and TyG-related Indicators in Obese Women
    Zahra Rashidi, Rezvan Beigi, Majid Mardaniyan Ghahfarrokhi, Mohammad Faramarzi, Ebrahim Banitalebi, Tina Jafari, Conrad P. Earnest, Julien S. Baker
    Obesity Medicine.2021; 24: 100351.     CrossRef
  • Effect of resistance training with and without caloric restriction on visceral fat: A systemic review and meta‐analysis
    Mousa Khalafi, Abbas Malandish, Sara K. Rosenkranz, Ali A. Ravasi
    Obesity Reviews.2021;[Epub]     CrossRef
  • The Effect of Elastic Resistance Band Training on Postural Control and Body Composition in Sedentary Women
    Yağmur KOCAOĞLU, Nurtekin ERKMEN
    Spor Bilimleri Araştırmaları Dergisi.2021; 6(1): 233.     CrossRef
  • Strength Training and Insulin Resistance: The Mediating Role of Body Composition
    McKayla J. Niemann, Larry A. Tucker, Bruce W. Bailey, Lance E. Davidson
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • Beyond general resistance training. Hypertrophy versus muscular endurance training as therapeutic interventions in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis
    Pedro Acosta‐Manzano, María Rodriguez‐Ayllon, Francisco M. Acosta, David Niederseer, Josef Niebauer
    Obesity Reviews.2020;[Epub]     CrossRef
  • Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
    Yubo Liu, Weibing Ye, Qian Chen, Yong Zhang, Chia-Hua Kuo, Mallikarjuna Korivi
    International Journal of Environmental Research and Public Health.2019; 16(1): 140.     CrossRef
  • Effectiveness of Exercise Intervention in Reducing Body Weight and Glycosylated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus in Korea: A Systematic Review and Meta-Analysis
    Ji-Eun Jang, Yongin Cho, Byung Wan Lee, Ein-Soon Shin, Sun Hee Lee
    Diabetes & Metabolism Journal.2019; 43(3): 302.     CrossRef
  • Effects of a moderate-to-high intensity resistance circuit training on fat mass, functional capacity, muscular strength, and quality of life in elderly: A randomized controlled trial
    Pablo Jorge Marcos-Pardo, Francisco Javier Orquin-Castrillón, Gemma María Gea-García, Ruperto Menayo-Antúnez, Noelia González-Gálvez, Rodrigo Gomes de Souza Vale, Alejandro Martínez-Rodríguez
    Scientific Reports.2019;[Epub]     CrossRef
  • Effects of Resistance Exercise on Glycated Hemoglobin and Functional Performance in Older Patients with Comorbid Diabetes Mellitus and Knee Osteoarthritis: A Randomized Trial
    Shu-Mei Chen, Feng-Chih Shen, Jung-Fu Chen, Wen-Dien Chang, Nai-Jen Chang
    International Journal of Environmental Research and Public Health.2019; 17(1): 224.     CrossRef
  • Effects of low‐intensity resistance training on muscular function and glycemic control in older adults with type 2 diabetes
    Eri Takenami, ShinMin Iwamoto, Noriko Shiraishi, Akiko Kato, Yuichi Watanabe, Yoshifumi Yamada, Satoru Yamada, Naokata Ishii
    Journal of Diabetes Investigation.2019; 10(2): 331.     CrossRef
  • Effect of 12-Month Resistance Training on Changes in Abdominal Adipose Tissue and Metabolic Variables in Patients with Prediabetes: A Randomized Controlled Trial
    Juan Yan, Xia Dai, Jitao Feng, Xiaodan Yuan, Jianing Li, Lihong Yang, Panpan Zuo, Zhaohui Fang, Chao Liu, Cunyi Hsue, Junya Zhu, Joshua D. Miller, Qingqing Lou
    Journal of Diabetes Research.2019; 2019: 1.     CrossRef
  • Positive Effects of a Short-Term Intense Elastic Resistance Training Program on Body Composition and Physical Functioning in Overweight Older Women
    Nicole B. Fritz, Álvaro Juesas, Pedro Gargallo, Joaquín Calatayud, Julio Fernández-Garrido, Michael E. Rogers, Juan C. Colado
    Biological Research For Nursing.2018; 20(3): 321.     CrossRef
  • Protein timing during the day and its relevance for muscle strength and lean mass
    Samuel L. Buckner, Jeremy P. Loenneke, Paul D. Loprinzi
    Clinical Physiology and Functional Imaging.2018; 38(2): 332.     CrossRef
  • Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis
    Bei Pan, Long Ge, Yang-qin Xun, Ya-jing Chen, Cai-yun Gao, Xue Han, Li-qian Zuo, Hou-qian Shan, Ke-hu Yang, Guo-wu Ding, Jin-hui Tian
    International Journal of Behavioral Nutrition and Physical Activity.2018;[Epub]     CrossRef
  • Resistance training reduces metabolic syndrome and inflammatory markers in older women: A randomized controlled trial
    Crisieli M. Tomeleri, Mariana F. Souza, Roberto C. Burini, Cláudia R. Cavaglieri, Alex S. Ribeiro, Melissa Antunes, João P. Nunes, Danielle Venturini, Décio S. Barbosa, Luís B. Sardinha, Edilson S. Cyrino
    Journal of Diabetes.2018; 10(4): 328.     CrossRef
  • Effect of Resistance Training with Blood Flow Restriction on Follistatin to Myostatin Ratio, Body Composition and Anaerobic Power of Trained-Volleyball Players
    Reza Bagheri, Amir Rashidlamir, Seyyed Reza Attarzadeh Hosseini
    Medical Laboratory Journal.2018; 12(6): 28.     CrossRef
  • Effects of 8-week kettlebell training on body composition, muscle strength, pulmonary function, and chronic low-grade inflammation in elderly women with sarcopenia
    Hung-Ting Chen, Huey-June Wu, Yu-Jen Chen, Sung-Yen Ho, Yu-Chun Chung
    Experimental Gerontology.2018; 112: 112.     CrossRef
  • F inding the O ptimal volume and intensity of R esistance T raining E xercise for Type 2 Diabetes: The FORTE Study, a Randomized Trial
    Pearl Yang, Walter Swardfager, Daniel Fernandes, Sheila Laredo, George Tomlinson, Paul I. Oh, Scott Thomas
    Diabetes Research and Clinical Practice.2017; 130: 98.     CrossRef
  • Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
    A. Sabag, K.L. Way, S.E. Keating, R.N. Sultana, H.T. O’Connor, M.K. Baker, V.H. Chuter, J. George, N.A. Johnson
    Diabetes & Metabolism.2017; 43(3): 195.     CrossRef
  • Resistance training to improve type 2 diabetes: working toward a prescription for the future
    Dominik H. Pesta, Renata L. S. Goncalves, Anila K. Madiraju, Barbara Strasser, Lauren M. Sparks
    Nutrition & Metabolism.2017;[Epub]     CrossRef
  • Improvement of obesity-linked skeletal muscle insulin resistance by strength and endurance training
    Sergio Di Meo, Susanna Iossa, Paola Venditti
    Journal of Endocrinology.2017; 234(3): R159.     CrossRef
  • Leisure time sedentary behavior, physical activity and frequency of protein consumption on lower extremity strength and lean mass
    P D Loprinzi, J P Loenneke, D L Hamilton
    European Journal of Clinical Nutrition.2017; 71(12): 1399.     CrossRef
  • Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals
    José D. Botezelli, Andressa Coope, Ana C. Ghezzi, Lucieli T. Cambri, Leandro P. Moura, Pedro P. M. Scariot, Rodrigo Stellzer Gaspar, Rania A. Mekary, Eduardo Rochete Ropelle, José Rodrigo Pauli
    Scientific Reports.2016;[Epub]     CrossRef
  • Effects of Elastic Band Resistance Training on Glucose Control, Body Composition, and Physical Function in Women With Short- vs. Long-Duration Type-2 Diabetes
    Bong-Sup Park, Andy V. Khamoui, Lee E. Brown, Do-Youn Kim, Kyung-Ah Han, Kyung-Wan Min, Geun-Hee An
    Journal of Strength and Conditioning Research.2016; 30(6): 1688.     CrossRef
  • Neuromuscular dysfunction in type 2 diabetes: underlying mechanisms and effect of resistance training
    Giorgio Orlando, Stefano Balducci, Ilenia Bazzucchi, Giuseppe Pugliese, Massimo Sacchetti
    Diabetes/Metabolism Research and Reviews.2016; 32(1): 40.     CrossRef
  • Physical exercises with free weights and elastic bands can improve body composition parameters in postmenopausal women
    Simoni T. Bittar, Sergio S. Maeda, Marília M.S. Marone, Cláudio Santili
    Menopause.2016; 23(4): 383.     CrossRef
  • Effects of exercise training using resistance bands on glycaemic control and strength in type 2 diabetes mellitus: a meta-analysis of randomised controlled trials
    Samantha K. McGinley, Marni J. Armstrong, Normand G. Boulé, Ronald J. Sigal
    Acta Diabetologica.2015; 52(2): 221.     CrossRef
  • Effect of exercise training on neuromuscular function of elbow flexors and knee extensors of type 2 diabetic patients
    I. Bazzucchi, G. De Vito, F. Felici, S. Dewhurst, A. Sgadari, M. Sacchetti
    Journal of Electromyography and Kinesiology.2015; 25(5): 815.     CrossRef
  • Effects of short term elastic resistance training on muscle mass and strength in untrained older adults: a randomized clinical trial
    Wagner Rodrigues Martins, Marisete Peralta Safons, Martim Bottaro, Juscelino Castro Blasczyk, Leonardo Rios Diniz, Romulo Maia Carlos Fonseca, Ana Clara Bonini-Rocha, Ricardo Jacó de Oliveira
    BMC Geriatrics.2015;[Epub]     CrossRef
  • Brain-derived neurotrophic factor correlated with muscle strength in subjects undergoing stationary bicycle exercise training
    Sen-Wei Tsai, Yin-Ching Chan, Francois Liang, Chiann-Yi Hsu, I-Te Lee
    Journal of Diabetes and its Complications.2015; 29(3): 367.     CrossRef
  • Implementation of Resources to Support Patient Physical Activity through Diabetes Centres in Nova Scotia: The Effectiveness of Enhanced Support for Exercise Participation
    Jonathon R. Fowles, Chris Shields, Lisette d’Entremont, Stephanie McQuaid, Brittany Barron, Peggy Dunbar
    Canadian Journal of Diabetes.2014; 38(6): 423.     CrossRef
  • Changes in insulin sensitivity in response to different modalities of exercise: a review of the evidence
    S. Mann, C. Beedie, S. Balducci, S. Zanuso, J. Allgrove, F. Bertiato, A. Jimenez
    Diabetes/Metabolism Research and Reviews.2014; 30(4): 257.     CrossRef
  • The surprising influence of family history to type 2 diabetes on anaerobic performance of young male élite athletes
    Antonino Bianco, Francesco Pomara, Antonino Patti, Ewan Thomas, Marco Petrucci, Marianna Bellafiore, Giuseppe Battaglia, Antonio Paoli, Antonio Palma
    SpringerPlus.2014;[Epub]     CrossRef
  • Skeletal muscle and organ masses differ in overweight adults with type 2 diabetes
    Lance E. Davidson, David E. Kelley, Stanley Heshka, John Thornton, F. Xavier Pi-Sunyer, Lawrence Boxt, Ashok Balasubramanyam, Dympna Gallagher
    Journal of Applied Physiology.2014; 117(4): 377.     CrossRef
  • The effects of elastic band resistance training combined with blood flow restriction on strength, total bone‐free lean body mass and muscle thickness in postmenopausal women
    Robert S. Thiebaud, Jeremy P. Loenneke, Christopher A. Fahs, Lindy M. Rossow, Daeyeol Kim, Takashi Abe, Mark A. Anderson, Kaelin C. Young, Debra A. Bemben, Michael G. Bemben
    Clinical Physiology and Functional Imaging.2013; 33(5): 344.     CrossRef
  • Predicting Aerobic Fitness Improvements after Participation in a Hybrid Supervised and Home-Based Exercise Program in People with Type 2 Diabetes
    Pearl Yang, Paul Oh
    Canadian Journal of Diabetes.2013; 37(6): 388.     CrossRef
  • Impacto do treinamento resistido na força e hipertrofia muscular em HIV-soropositivos
    Ciro José Brito, Edmar Lacerda Mendes, Aparecido Pimentel Ferreira, Sérgio Oliveira De Paula, Otávio de Tolêdo Nóbrega, Cláudio Córdova
    Motriz: Revista de Educação Física.2013; 19(2): 313.     CrossRef
  • Resistance Training for Diabetes Prevention and Therapy: Experimental Findings and Molecular Mechanisms
    Barbara Strasser, Dominik Pesta
    BioMed Research International.2013; 2013: 1.     CrossRef
  • Resistance training, visceral obesity and inflammatory response: a review of the evidence
    B. Strasser, M. Arvandi, U. Siebert
    Obesity Reviews.2012; 13(7): 578.     CrossRef
  • The effects of resistance training on ApoB/ApoA-I ratio, Lp(a) and inflammatory markers in patients with type 2 diabetes
    Nikolaos P. E. Kadoglou, Grigorios Fotiadis, Zoi Athanasiadou, Ioulia Vitta, Stylianos Lampropoulos, Ioannis S. Vrabas
    Endocrine.2012; 42(3): 561.     CrossRef
  • A systematic review and meta‐analysis of the effect of aerobic vs. resistance exercise training on visceral fat
    I. Ismail, S. E. Keating, M. K. Baker, N. A. Johnson
    Obesity Reviews.2012; 13(1): 68.     CrossRef
  • Aging, Resistance Training, and Diabetes Prevention
    Kyle D. Flack, Kevin P. Davy, Matthew W. Hulver, Richard A. Winett, Madlyn I. Frisard, Brenda M. Davy
    Journal of Aging Research.2011; 2011: 1.     CrossRef
  • The Effects of Aerobic/Resistance Exercise on Body Fat Mass, Muscle Strength and Endothelial Function in Korean Type 2 Diabetes mellitus Patients
    Kyung Wan Min
    Journal of Korean Diabetes.2011; 12(1): 6.     CrossRef
  • Exercise and Type 2 Diabetes
    Sheri R. Colberg, Ronald J. Sigal, Bo Fernhall, Judith G. Regensteiner, Bryan J. Blissmer, Richard R. Rubin, Lisa Chasan-Taber, Ann L. Albright, Barry Braun
    Diabetes Care.2010; 33(12): e147.     CrossRef
Randomized Controlled Trial
The Effects of Low-Calorie Diets on Abdominal Visceral Fat, Muscle Mass, and Dietary Quality in Obese Type 2 Diabetic Subjects.
Hee Jung Ahn, Youn Ok Cho, Hwi Ryun Kwon, Yun Hyi Ku, Bo Kyung Koo, Kyung Ah Han, Kyung Wan Min
Korean Diabetes J. 2009;33(6):526-536.   Published online December 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.6.526
  • 2,792 View
  • 57 Download
  • 7 Crossref
AbstractAbstract PDF
BACKGROUND
Weight loss through low-calorie diets (LCDs) decreases visceral fat (VF). However, the effects on muscle mass, changes of dietary quality, and insulin sensitivity are unknown for Korean obese type 2 diabetic subjects. Therefore, this study examined such effects of LCDs. METHODS: A total of 30 obese type 2 diabetic subjects (body mass index, 27.0 +/- 2.2 kg/m2) were randomly assigned to an LCD or control group. Subjects on LCDs took 500~1,000 kcal fewer energy than their usual dietary intake (1,000~1,500 kcal/day) over the course of 12 weeks. The abdominal VF and femoral muscle mass were evaluated by computed tomography, and insulin sensitivity was assessed using an insulin tolerance test (Kitt; rate constant for plasma glucose disappearance, %/min). Dietary nutrient intake consumed by subjects was assessed by 3-day food records. RESULTS: The percent VF reduction was -23.4 +/- 17.2% in the LCD group and -9.8 +/- 11.8% in the control group after 12 weeks (P < 0.001, P = 0.002). However, significant decrease in femoral mass or proportional change of marcronutrient intake and mean adequacy ratio were not found in the LCD group, as compared to the control group. Insulin sensitivity improved in the LCD group, as compared to the control group (P = 0.040). CONCLUSION: LCD effectively improved insulin sensitivity and reduced abdominal VF without reduction of femoral muscle and dietary quality in obese type 2 diabetic subjects.

Citations

Citations to this article as recorded by  
  • The association between measurement sites of visceral adipose tissue and cardiovascular risk factors after caloric restriction in obese Korean women
    Hye-Ok Lee, Jung-Eun Yim, Jeong-Sook Lee, Young-Seol Kim, Ryowon Choue
    Nutrition Research and Practice.2013; 7(1): 43.     CrossRef
  • Effects of age on changes of body composition through caloric restriction in overweight and obese women
    Jung-Eun Yim, Young-Seol Kim, Ryowon Choue
    Journal of Nutrition and Health.2013; 46(5): 410.     CrossRef
  • The effects of weight loss by a low-calorie diet and a low-calorie plus exercise in overweight undergraduate students
    Gun-Ae Yoon, Hyun-Ho Ahn, Bo-Hae Park, Danbi Yoo, Sunmin Park
    Korean Journal of Nutrition.2012; 45(4): 315.     CrossRef
  • Effect of an abdominal obesity management program on dietary intake, stress index, and waist to hip ratio in abdominally obese women - Focus on comparison of the WHR decrease and WHR increase groups -
    Ji Won Lee, Sook Young Yoo, So Young Yang, Hyesook Kim, Seong Kyung Cho
    Korean Journal of Nutrition.2012; 45(2): 127.     CrossRef
  • The Evaluation of Workplace Obesity Intervention Program using Six Sigma Methodology
    Ji Yeon Kang, Ill Keun Park, Yun Kyun Chang, Sook Hee Sung, Yoo Kyoung Park, Sang Woon Cho, Yun Mi Paek, Tae In Choi
    The Korean Journal of Obesity.2011; 20(4): 193.     CrossRef
  • The Usefulness of an Accelerometer for Monitoring Total Energy Expenditure and Its Clinical Application for Predicting Body Weight Changes in Type 2 Diabetic Korean Women
    Ji Yeon Jung, Kyung Ah Han, Hwi Ryun Kwon, Hee Jung Ahn, Jae Hyuk Lee, Kang Seo Park, Kyung Wan Min
    Korean Diabetes Journal.2010; 34(6): 374.     CrossRef
  • The Effects of Low-Calorie Diets on Abdominal Visceral Fat, Muscle Mass, and Dietary Quality in Obese Type 2 Diabetic Subjects (Korean Diabetes J 2009;33:526-36)
    Won-Young Lee
    Korean Diabetes Journal.2010; 34(1): 66.     CrossRef
Original Article
Relationship of Maximal Muscle Strength with Body Mass Index and Aerobics Capacity in Type 2 Diabetic Patients.
Hwi Ryun Kwon, Kyung Ah Han, Yun Hyi Ku, Hee Jung Ahn, Bo Kyung Koo, Kyung Wan Min
Korean Diabetes J. 2009;33(6):511-517.   Published online December 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.6.511
  • 2,515 View
  • 46 Download
  • 4 Crossref
AbstractAbstract PDF
BACKGROUND
Combination fitness regimens (including aerobic and resistance exercises) are effective for improving cardio-respiratory fitness, reducing visceral fat and increasing insulin sensitivity in diabetic patients. The combination exercise intensity that a patient is capable of is limited by his or her aerobic capacity and one repetition maximum (1RM). We investigated the relationships between 1RM, aerobic exercise capacity and body mass index in patients with type 2 diabetes. METHODS: A total of 177 (men: 85, women: 92) diabetic subjects with HbA1c < or = 10% were enrolled. Muscle strength and 1RM were assessed bychest press (upper body) and leg press (lower body). We assessed aerobic capacity by VO2max and muscle mass by bioimpedance analysis. RESULTS: There was no correlation between 1RM and VO2max in type 2 diabetic patients (upper: P = 0.122, lower: P = 0.138 for men, and upper: P = 0.952, lower: P = 0.570 for women). However, 1RM was significantly correlated with muscle mass both in men and women (upper: r = 0.493, P < 0.001, r = 0.315, P = 0.002 lower: r = 0.437 P < 0.001, r = 0.307, P =0.003, respectively). There was also a significant correlation between 1RM and BMI. In obese male subjects with BMI > or = 25 kg/m2, we observed a significant correlation between muscle mass and BMI (r = 0.374, P = 0.032), but this correlation was not observed in women. CONCLUSION: Clinicians treating Korean type 2 diabetic subjects should recommend resistance exercise to their patients. In particular, obese women with diabetes may receive greater benefits by increasing muscle mass through resistance exercises.

Citations

Citations to this article as recorded by  
  • Evaluation of Muscle Strength and Endurance in Postmenopausal Women: A Cross-sectional Study
    Arati V Mahishale, Manali P Kulkarni
    Journal of South Asian Federation of Obstetrics and Gynaecology.2021; 13(3): 163.     CrossRef
  • The Correlations between Extremity Circumferences with Total and Regional Amounts of Skeletal Muscle and Muscle Strength in Obese Women with Type 2 Diabetes
    Hwi Ryun Kwon, Kyung Ah Han, Hee Jung Ahn, Jae Hyuk Lee, Gang Seo Park, Kyung Wan Min
    Diabetes & Metabolism Journal.2011; 35(4): 374.     CrossRef
  • The Effects of Aerobic/Resistance Exercise on Body Fat Mass, Muscle Strength and Endothelial Function in Korean Type 2 Diabetes mellitus Patients
    Kyung Wan Min
    Journal of Korean Diabetes.2011; 12(1): 6.     CrossRef
  • The Effects of Resistance Training on Muscle and Body Fat Mass and Muscle Strength in Type 2 Diabetic Women
    Hwi Ryun Kwon, Kyung Ah Han, Yun Hyi Ku, Hee Jung Ahn, Bo-Kyung Koo, Ho Chul Kim, Kyung Wan Min
    Korean Diabetes Journal.2010; 34(2): 101.     CrossRef
Randomized Controlled Trial
Effects of Adding omega-3 Fatty Acids to Simvastatin on Lipids, Lipoprotein Size and Subspecies in Type 2 Diabetes Mellitus with Hypertriglyceridemia.
Won Jun Kim, Chang Beom Lee, Cheol Young Park, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Dae Jung Kim, Hae Jin Kim, Seung Jin Han, Hong Keum Cho
Korean Diabetes J. 2009;33(6):494-502.   Published online December 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.6.494
  • 2,832 View
  • 41 Download
AbstractAbstract PDF
BACKGROUND
omega-3 fatty acids are known to improve lipid profiles, the distribution of lipoprotein subclasses, and secondary prevention against post-myocardial infarction. Rare reports have emerged of synergistic results of omega-3 fatty acids with simvastatin in cases of type 2 diabetes mellitus with hypertriglyceridemia. The purpose of this study was to determine the combined relationship of omega-3 fatty acids plus simvastatin on lipid, lipoprotein size and the types of subspecies. METHODS: This randomized, multi-center, comparison study evaluated eight weeks of combination therapy (omega-3 fatty acids (Omacor) 4 g/day plus simvastatin 20 mg/day) or monotherapy (simvastatin 20 mg/day) for at least six weeks in 62 diabetic patients. Subjects with a triglyceride concentration of more than 200 mg/dL were eligible for inclusion. RESULTS: No significant differences for omega-3 fatty acids + simvastatin versus simvastatin alone were observed for triglycerides (-22.7% vs. -14.3%, P = 0.292), HDL peak particle size (+2.8% vs. -0.4%, P = 0.076), LDL mean particle size (+0.4% vs -0.1%, P = 0.376) or LDL subspecies types, although the combination therapy showed a tendency toward lower triglycerides, larger HDL, and LDL particle sizes than did the monotherapy. There were no significant differences between the two groups in regard to HDL-C, LDL-C, or HbA1c levels. There were no serious adverse events and no abnormalities in the laboratory values associated with this study. CONCLUSION: omega-3 fatty acids were a safeform of treatment in hypertriglyceridemic patients with type 2 diabetes mellitus. But, regarding efficacy, a much larger sample size and longer-term follow-up may be needed to distinguish between the effects of combination therapy and monotherapy.
Original Articles
The Relationship Between Coronary Artery Calcification and Serum Apolipoprotein A-1 in Patients with Type 2 Diabetes.
Hyun Ae Seo, Yeon Kyung Choi, Jae Han Jeon, Jung Eun Lee, Ji Yun Jeong, Seong Su Moon, In Kyu Lee, Bo Wan Kim, Jung Guk Kim
Korean Diabetes J. 2009;33(6):485-493.   Published online December 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.6.485
  • 2,765 View
  • 36 Download
  • 2 Crossref
AbstractAbstract PDF
BACKGROUND
The incidence of type 2 diabetes mellitus is increasing annually and patient mortality is high. Coronary artery calcification is a predictor of coronary artery disease. Cardiovascular events, which are the main cause of death in type 2 diabetes patients, may be preventable by addressing risk factors associated with coronary artery calcification. We examined the relationships between coronary artery calcification, lipid profiles, and apolipoprotein levels. METHODS: We calculated the coronary calcium scores (CCS) of 254 subjects with type 2 diabetes (113 males, 141 females) via multi-detector row computed tomography (MDCT). Height, body weight, blood pressure, HbA1c, c-peptide, lipid profile and apolipoprotein were assessed concurrently. RESULTS: In patients with type 2 diabetes, Agatston score and apolipoprotein A-1 were significantly negatively correlated in both males and females (males P = 0.015, females P = 0.021). The negative correlation between Agatston score and apolipoprotein A-1 was retained for the entire patient sample after adjustments for age and sex (P = 0.022). Stepwise multiple regression anaylses with the Agatston score as the dependent variable indicate that apolipoprotein A-1 is a independent predictor (beta coefficient = -0.047, 95%CI = -0.072 ~ -0.021, P < 0.001) of coronary artery calcification. CONCLUSION: The results of our study suggest that apolipoprotein A-1 is a useful independent indicator of coronary artery calcification.

Citations

Citations to this article as recorded by  
  • The Risk of Coronary Artery Calcification according to Different Lipid Parameters and Average Lipid Parameters
    Tae Kyung Yoo, Mi Yeon Lee, Ki-Chul Sung
    Journal of Atherosclerosis and Thrombosis.2024; 31(8): 1194.     CrossRef
  • Coronary Artery Calcification and Serum Apolipoprotein A-1 in Patients with Type 2 Diabetes
    Ki Won Oh
    Korean Diabetes Journal.2009; 33(6): 464.     CrossRef
Leptin is Negatively Associated with Femoral Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus.
Jae Han Jeon, Yeun Kyung Choi, Hyun Ae Seo, Jung Eun Lee, Ji Yun Jeong, Seong Su Moon, Ju Young Lee, Jung Guk Kim, Bo Wan Kim, In Kyu Lee
Korean Diabetes J. 2009;33(5):421-431.   Published online October 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.5.421
  • 2,505 View
  • 20 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
Serum leptin level and bone mineral density (BMD) are widely assumed to be positively associated with body fat mass. Numerous attempts have been made to document the relationship between leptin and BMD, but the results are inconsistent, especially in diabetic patients. METHODS: A total of 60 Korean postmenopausal women with type 2 diabetes mellitus were included in the present study. The BMDs of lumbar spines (L1 to L4) and proximal femurs (trochanter, neck, and total) were measured by dual-energy X-ray absorptiometry (DXA), and biochemical markers including leptin, HbA1c, C-peptide and urine albumin-creatinine ratio (ACR) were measured for each patient. RESULTS: Negative associations between leptin and BMD of femoral neck, trochanter, and total femur in postmenopausal women with type 2 diabetes mellitus were documented in a model adjusted for age, body fat mass, and fasting insulin level (r = -0.308, P = 0.020 and r = - 0.303, P = 0.025 and r = - 0.290, P = 0.032 respectively). Multiple linear regression analysis was performed revealing negative associations between leptin and BMD of the femoral neck (beta = -0.369), trochanter (beta = -0.324), and total femur (beta = -0.317). CONCLUSION: The results of the present study suggest a negative relationship between leptin and femoral BMD. In addition, leptin may have a negative effect on BMD in postmenopausal women with type 2 diabetes mellitus.

Citations

Citations to this article as recorded by  
  • Evaluation of bone mineral density in type 2 diabetes mellitus patients before and after treatment
    MK Dutta, R Pakhetra, MK Garg
    Medical Journal Armed Forces India.2012; 68(1): 48.     CrossRef
Maximal Muscle Strength Deteriorates with Age in Subjects with Type 2 Diabetes Mellitus.
Hwi Ryun Kwon, Yun Hyi Ku, Hee Jung Ahn, Ji Yun Jeong, Sang Ryol Ryu, Bo Kyung Koo, Kyung Ah Han, Kyung Wan Min
Korean Diabetes J. 2009;33(5):412-420.   Published online October 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.5.412
  • 2,809 View
  • 25 Download
  • 5 Crossref
AbstractAbstract PDF
BACKGROUND
It is difficult to improve muscle strength with only aerobic exercise training in type 2 diabetes patients. Resistance training is effective for improving muscle mass, muscle strength and insulin sensitivity. One repetition maxima (1RM), or the maximum amount of weight a subject can lift in a single repetition, may be a useful unit for evaluating the results of resistance training in type 2 diabetic patients. This study was aimed to assess baseline values for 1RM in a sample of Korean type 2 diabetes mellitus patients that are scaled for intensity and load of exercise, and to assess the relationship of 1RM to age. METHODS: A total of 266 (male: 95, female: 171) Korean patients with type 2 diabetes mellitus were included in the study sample. Maximal muscle strength was assessed by measuring 1RM for each subject (KEISER, Fresno, CA, USA). Two different exercises were used to measure 1RM: the chest press for the upper extremities, and the leg press for the lower extremities. RESULTS: Both upper and lower values of 1RM decreased with age in men and women; upper 1RM: r = -0.454, P<0.001 in men, r = -0.480, P< 0.001 in women, lower 1RM: r = -0.569, P<0.001 in men, and r = -0.452, P<0.001 in women. Values of 1RM significantly decreased in men only after the age of 70. In women, values of 1RM continuously decreased after the age of 60. CONCLUSION: The maximal muscle strength of individuals with type 2 diabetes decreases with age. We believe that resistance training is especially beneficial for type 2 diabetes mellitus patients after the sixth decade of life.

Citations

Citations to this article as recorded by  
  • The Effects of Floor-seated Exercise Program on Physical Fitness, Depression, and Sleep in Older Adults: A Cluster Randomized Controlled Trial
    Min-Jung Choi, Kyeong-Yae Sohng
    International Journal of Gerontology.2018; 12(2): 116.     CrossRef
  • The Effects of Aerobic/Resistance Exercise on Body Fat Mass, Muscle Strength and Endothelial Function in Korean Type 2 Diabetes mellitus Patients
    Kyung Wan Min
    Journal of Korean Diabetes.2011; 12(1): 6.     CrossRef
  • The Correlations between Extremity Circumferences with Total and Regional Amounts of Skeletal Muscle and Muscle Strength in Obese Women with Type 2 Diabetes
    Hwi Ryun Kwon, Kyung Ah Han, Hee Jung Ahn, Jae Hyuk Lee, Gang Seo Park, Kyung Wan Min
    Diabetes & Metabolism Journal.2011; 35(4): 374.     CrossRef
  • The Effects of Resistance Training on Muscle and Body Fat Mass and Muscle Strength in Type 2 Diabetic Women
    Hwi Ryun Kwon, Kyung Ah Han, Yun Hyi Ku, Hee Jung Ahn, Bo-Kyung Koo, Ho Chul Kim, Kyung Wan Min
    Korean Diabetes Journal.2010; 34(2): 101.     CrossRef
  • Relationship of Maximal Muscle Strength with Body Mass Index and Aerobics Capacity in Type 2 Diabetic Patients
    Hwi Ryun Kwon, Kyung Ah Han, Yun Hyi Ku, Hee Jung Ahn, Bo Kyung Koo, Kyung Wan Min
    Korean Diabetes Journal.2009; 33(6): 511.     CrossRef
Randomized Controlled Trial
Effects of Aerobic Exercise Intensity on Insulin Resistance in Patients with Type 2 Diabetes Mellitus.
Yun Hyi Ku, Bo Kyung Koo, Hee Jung Ahn, Ji Yun Jeong, Hee Geum Seok, Ho Chul Kim, Kyung Ah Han, Kyung Wan Min
Korean Diabetes J. 2009;33(5):401-411.   Published online October 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.5.401
  • 3,335 View
  • 49 Download
  • 7 Crossref
AbstractAbstract PDF
BACKGROUND
Exercise offers protection against atherosclerosis and insulin resistance. We evaluated the benefits of exercise at different levels of intensity for ameliorating inflammation, endothelial dysfunction, and insulin resistance in a sample of type 2 diabetic subjects. METHODS: Fifty-nine overweight women with type 2 diabetes were randomly assigned to control (CG, N = 18), moderate-intensity exercise (MEG, N = 17), and vigorous-intensity exercise (VEG, N = 14) groups. Patients in the two experimental groups completed a 12-week exercise program, with their exercise activities monitored by accelerometers. We assessed the patients' body weights, total abdominal fat (TF), subcutaneous fat (SF) and visceral fat (VF) via computed tomography, measurements of plasma levels of hs-C-reactive protein (hs-CRP) and interleukin-6 (IL-6), assessment of endothelial function by brachial artery flow-mediated dilation (FMD), and evaluation of insulin sensitivity by insulin tolerance tests, at baseline, at the end of the 12-week interventions, and one year after initiation of the study. RESULTS: At baseline, the average age of all subjects was 54 +/- 7 years, and average body mass index (BMI) was 26.9 +/- 2.5 kg/m2. During the intervention, patients in the MEG and VEG groups expended comparable amounts of activity-related calories (488.6 +/- 111.9 kcal/day, 518.8 +/- 104.1 kcal/day, respectively). Although BMI, TF, and SF decreased similarly in the MEG and VEG groups (deltaBMI: -1.1 +/- 0.7, -0.8 +/- 0.5, deltaTF: -4,647 +/- 3,613 mm2, -2,577 +/- 2,872 mm2, deltaSF: -2,057 +/- 2,021 mm2, -1,141 +/- 1,825 mm2, respectively), compared to control (P<0.01), hs-CRP, IL-6, and FMD remained constant in both exercise groups even after completion of the 12-week exercise intervention. Insulin sensitivity improved only in patients subjected to vigorous exercise (VEG). Visceral fat loss was observed only in patients subjected to moderate exercise (MEG). At one-year follow up, these values had all returned to baseline. CONCLUSION: Exercise vigorous enough to result in significant weight and fat reduction did not ameliorate inflammation and endothelial dysfunction as measured at the end of a 12-week exercise intervention, nor did it result in sustained improvements in insulin sensitivity in type 2 diabetic subjects.

Citations

Citations to this article as recorded by  
  • Different intensities of aerobic training for patients with type 2 diabetes mellitus and knee osteoarthritis: a randomized controlled trial
    Chi Su, Lihua Huang, Shaochen Tu, Shengdi Lu
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • The anti-inflammatory effects of aerobic exercise training in patients with type 2 diabetes: A systematic review and meta-analysis
    Georgia Papagianni, Chrystalla Panayiotou, Michail Vardas, Nikolaos Balaskas, Constantinos Antonopoulos, Dimitrios Tachmatzidis, Triantafyllos Didangelos, Vaia Lambadiari, Nikolaos P.E. Kadoglou
    Cytokine.2023; 164: 156157.     CrossRef
  • Effects of Exercise on Inflammatory Cytokines in Patients with Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials
    Xiaoke Chen, Xinzheng Sun, Chenghao Wang, Hui He, Jos L. Quiles
    Oxidative Medicine and Cellular Longevity.2020; 2020: 1.     CrossRef
  • Effect of Diabetic Dietary Education Program on Diabetes Knowledge and Dietary Behaviors of Elderly Diabetic Patients
    Ji Young Ye, Sung Hee Min, Min June Lee
    Korean Journal of Food & Cookery Science.2017; 33(5): 601.     CrossRef
  • Effect of aerobic exercise intensity on glycemic control in type 2 diabetes: a meta-analysis of head-to-head randomized trials
    Yilina Liubaoerjijin, Tasuku Terada, Kevin Fletcher, Normand G. Boulé
    Acta Diabetologica.2016; 53(5): 769.     CrossRef
  • Letter: Effects of Aerobic Exercise Intensity on Insulin Resistance in Patients with Type 2 Diabetes Mellitus (Korean Diabetes J 33(5):401-411, 2009)
    Dong-Lim Kim
    Korean Diabetes Journal.2009; 33(6): 547.     CrossRef
  • Response: Effects of Aerobic Exercise Intensity on Insulin Resistance in Patients with Type 2 Diabetes Mellitus (Korean Diabetes J 33:(5)401-411, 2009)
    Yun Hyi Ku, Bo-Kyung Koo, Kyung-Wan Min
    Korean Diabetes Journal.2009; 33(6): 549.     CrossRef
Original Articles
Relationship Between Metabolic Syndrome and Risk of Chronic Complications in Koreans with Type 2 Diabetes.
Hye Soo Chung, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Doo Man Kim, Choon Hee Chung, Dong seop Choi
Korean Diabetes J. 2009;33(5):392-400.   Published online October 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.5.392
  • 2,446 View
  • 33 Download
  • 6 Crossref
AbstractAbstract PDF
BACKGROUND
We examined the relationships between components of metabolic syndrome at the time of diagnosis of type 2 diabetes, and the development of chronic complications in Korean patients with type 2 diabetes. METHODS: The medical records of patients with type 2 diabetes who had undergone treatment for at least five years prior were collected from 10 general hospitals in Korea. Among a total of 1,418 patients reviewed for possible inclusion in this study, 603 patients were selected, and the occurrence of complications among these patients was evaluated. RESULTS: Among the 603 patients (male, 253; female, 350), 154 males (60.8%) and 266 females (76.0%) were diagnosed with metabolic syndrome at the time of initial diagnosis of type 2 diabetes. The incidence of chronic complications (average follow-up 15.2 +/- 4.9 years) included 60 cases of coronary artery disease (CAD), 57 cases of cerebrovascular accident (CVA), 268 cases of diabetic retinopathy (DR), 254 cases of diabetic nephropathy (DN), and 238 cases of diabetic peripheral neuropathy (DPN). As compared to patients without metabolic syndrome, the adjusted relative risks (95% CI) of incidental diabetic complications in patients with metabolic syndrome were 3.28 (1.40~7.71) for CAD, 2.04 (0.86~4.82) for CVA, 1.53 (1.10~2.14) for DR, 1.90 (1.29~2.80) for DN, and 1.51, (1.06~2.14) for DPN. With the addition of just one constituent of metabolic syndrome, the relative risk of developing CAD, CVD, DR, DN, and DPN increased by 2.08 (95% CI, 1.27~3.40), 1.16 (0.80~1.66), 1.09 (0.93~1.26), 1.29 (1.06~1.57) and 1.06 (0.87~1.26), respectively. CONCLUSION: Metabolic syndrome in Korean patients with type 2 diabetes increases the risk of developing both macrovascular and microvascular complications.

Citations

Citations to this article as recorded by  
  • COVID-19 pandemic: Effects of national lockdown on the state of health of patients with type 2 diabetes mellitus in a Moroccan population
    Hamid Farhane, Majida Motrane, Fatima-Ezzahra Anaibar, Aïcha Motrane, Said Nassor Abeid, Nourdin Harich
    Primary Care Diabetes.2021; 15(5): 772.     CrossRef
  • Profil clinique du syndrome métabolique et facteurs associés à sa présence au cours du diabète de type 2 à Ouagadougou (Burkina Faso)
    O. Guira, H. Tiéno, Y. Sagna, P. Mayodé, D. Yanogo, L. Zoungrana, C.-G. Kyélem, M.-T. Yaméogo, J.-Y. Drabo
    Médecine des Maladies Métaboliques.2016; 10(1): 70.     CrossRef
  • The Relationship between Metabolic Syndrome and Quality of Life in Korean Adult Women
    Hyung-Su Park, Jong Park
    The Journal of the Korea institute of electronic communication sciences.2013; 8(4): 639.     CrossRef
  • Diabetes Risk Analysis Model with Personalized Food Intake Preference
    So-Hye Jeon, Nam-Hyun Kim
    Journal of the Korea Academia-Industrial cooperation Society.2013; 14(11): 5771.     CrossRef
  • Comorbidity Study on Type 2 Diabetes Mellitus Using Data Mining
    Hye Soon Kim, A Mi Shin, Mi Kyung Kim, Yoon Nyun Kim
    The Korean Journal of Internal Medicine.2012; 27(2): 197.     CrossRef
  • Cardio-Metabolic Features of Type 2 Diabetes Subjects Discordant in the Diagnosis of Metabolic Syndrome
    Sa Rah Lee, Ying Han, Ja Won Kim, Ja Young Park, Ji Min Kim, Sunghwan Suh, Mi-Kyoung Park, Hye-Jeong Lee, Duk Kyu Kim
    Diabetes & Metabolism Journal.2012; 36(5): 357.     CrossRef
Genetic Association of Mitochondrial DNA Polymorphisms with Type 2 Diabetes Mellitus.
Tae Su Han, Jee Hye Choi, Jina Park, Kwang Ho Lee, Ae Ja Park
Korean Diabetes J. 2009;33(5):382-391.   Published online October 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.5.382
  • 2,071 View
  • 42 Download
AbstractAbstract PDF
BACKGROUND
Although many single nucleotide polymorphisms (SNPs) of mtDNA have been found to be associated with type 2 diabetes mellitus, the results of studies using different population samples and different methods are mixed. Therefore, we conducted a genetic association study of mtDNA SNPs and type 2 diabetes mellitus in a Korean sample and compared our results with those of studies conducted in other human populations. METHODS: A total of 298 blood samples from 147 type 2 diabetic patients and 151 normal controls were surveyed for SNPs via PCR directed sequencing. Sequencing analyses were performed using the SeqMan module of the DNASTAR program. The identified SNPs were compared to previously reported SNP lists on NCBI and V-mitoSNP. RESULTS: A total of 24 SNPs were identified in the MT-RNR2, MR-TL1 and MT-ND1 mtDNA genes in Korean type 2 diabetes mellitus patients and normal controls. The SNPs identified in the Korean sample were not closely associated with the type 2 diabetes mellitus phenotype, a significantly different result from those previously observed in European, Chinese and Japanese samples. Additionally, a haplotype and prevalence analysis could not detect any differences between the type 2 diabetes mellitus patients and normal controls. CONCLUSION: The 24 mtDNA SNPs were not associated with type 2 diabetes mellitus risk in our Korean sample. The results of the present study support the possibility that mtDNA SNPs have a differential effect on the risk of type 2 diabetes mellitus according to geographical origin.
Association Between Volume of Bowls and the Dietary Intakes in Subjects with Type 2 Diabetes.
Hee Jung Ahn, Bo Kyung Koo, Ji Yeon Jung, Hwi Ryun Kwon, Mi Yeon Chung, Yun Hyi Ku, Jin Taek Kim, Kyung Ah Han, Kyung Wan Min
Korean Diabetes J. 2009;33(4):335-343.   Published online August 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.4.335
  • 2,913 View
  • 26 Download
  • 6 Crossref
AbstractAbstract PDF
BACKGROUND
The results of previous studies suggest that portion size is a major factor dictating dietary energy intake. We investigated the relationship between frequencies of rice meals, bowl volumes, and dietary energy intake in a sample of patients with type 2 diabetes. METHODS: A total of 203 type 2 diabetes patients were enrolled in the study. A one-week food diary was collected from each patient and used to assess the types of meal consumed as well as the context of consumption. The volumes of the eating vessels (rice, soup and side dish bowls) used by each patient were obtained by comparisons to measuring cylinders, and dietary energy and macronutrient intake were estimated for each patient by consulting three-day dietary records. RESULTS: The mean age of the 203 subjects (male: 76, female: 127) was 53.9 +/- 9.1 years and the average body mass index (BMI) was 25.6 +/- 4.2 kg/m2. Among the subjects who ate three times per day, 96.4% consumed rice more than twice out of three meals. The median volume of rice bowls used by patients was 350 cc, of soup bowls was 530 cc and of side dish bowls was 260 cc. Portion size, as estimated by rice bowl volume, was not associated with BMI. Male subjects tended to eat out of larger rice and soup bowls (P < 0.001). Portion size was correlated with energy intake from rice (P = 0.021), but not with total energy intake (kcal/kg/day), especially in male subjects. CONCLUSION: Portion size of rice bowl was correlated with energy intake from rice, but not with total energy intake in male subjects with type 2 diabetes. To design effective meal planning methods for patients with type 2 diabetes, further prospective studies are warranted to investigate causative relationships between portion size andmetabolic conditions as well as variation by gender.

Citations

Citations to this article as recorded by  
  • Trends in adherence to dietary recommendations among Korean type 2 diabetes mellitus patients
    Kyong Park
    Nutrition Research and Practice.2015; 9(6): 658.     CrossRef
  • Small Rice Bowl-Based Meal Plan for Energy and Marcronutrient Intake in Korean Men with Type 2 Diabetes: A Pilot Study
    Hee Jung Ahn, Kyung Ah Han, Jin Young Jang, Jae Hyuk Lee, Kang Seo Park, Kyung Wan Min
    Diabetes & Metabolism Journal.2011; 35(3): 273.     CrossRef
  • Nutrients and Dish Intake by Fasting Blood Glucose Level
    Jihyun Choi, Hyun-Kyung Moon
    The Korean Journal of Nutrition.2010; 43(5): 463.     CrossRef
  • Small Rice Bowl-Based Meal Plan versus Food Exchange-Based Meal Plan for Weight, Glucose and Lipid Control in Obese Type 2 Diabetic Patients
    Hee-Jung Ahn, Kyung-Ah Han, Hwi-Ryun Kwon, Bo-Kyung Koo, Hyun-Jin Kim, Kang-Seo Park, Kyung-Wan Min
    Korean Diabetes Journal.2010; 34(2): 86.     CrossRef
  • The Effects of Small Sized Rice Bowl on Carbohydrate Intake and Dietary Patterns in Women with Type 2 Diabetes
    Hee-Jung Ahn, Yu-Kyung Eom, Kyung-Ah Han, Hwi-Ryun Kwon, Hyun Jin Kim, Kang Seo Park, Kyung-Wan Min
    Korean Diabetes Journal.2010; 34(3): 166.     CrossRef
  • The Small Rice Bowl-Based Meal Plan was Effective at Reducing Dietary Energy Intake, Body Weight, and Blood Glucose Levels in Korean Women with Type 2 Diabetes Mellitus
    Hee Jung Ahn, Kyung Ah Han, Hwi Ryun Kwon, Kyung Wan Min
    Korean Diabetes Journal.2010; 34(6): 340.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP