Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal



Page Path
HOME > Search
1 "Peroxisome proliferator activated receptor agonists"
Article category
Publication year
Refocusing Peroxisome Proliferator Activated Receptor-α: A New Insight for Therapeutic Roles in Diabetes
Hannah Seok, Bong Soo Cha
Diabetes Metab J. 2013;37(5):326-332.   Published online October 17, 2013
  • 2,825 View
  • 30 Download
  • 19 Crossref
AbstractAbstract PDFPubReader   

Although glucose-lowering treatment shows some risk lowering effects in cardiovascular diseases, risks of macrovascular and microvascular complications have still remained, and development of new therapeutic strategies is needed. Recent data have shown that peroxisome proliferator activated receptor-α (PPAR-α) plays a pivotal role in the regulation of lipid homeostasis, fatty acid oxidation, cellular differentiation, and immune response such as inflammation or vascularization related to diabetic complication. This review will re-examine the metabolic role of PPAR-α, summarize data from clinical studies on the effect of PPAR-α agonist in diabetes, and will discuss the possible therapeutic role of PPAR-α activation.


Citations to this article as recorded by  
  • Recent Insights into the Etiopathogenesis of Diabetic Retinopathy and Its Management
    Arpon Biswas, Abhijit Deb Choudhury, Sristi Agrawal, Amol Chhatrapati Bisen, Sachin Nashik Sanap, Sarvesh Kumar Verma, Mukesh Kumar, Anjali Mishra, Shivansh Kumar, Mridula Chauhan, Rabi Sankar Bhatta
    Journal of Ocular Pharmacology and Therapeutics.2024; 40(1): 13.     CrossRef
  • Counteracting health risks by Modulating Homeostatic Signaling
    Junqiang J. Tian, Mark Levy, Xuekai Zhang, Robert Sinnott, Rolando Maddela
    Pharmacological Research.2022; 182: 106281.     CrossRef
  • Moringa oleifera leaf extract influences oxidative metabolism in C2C12 myotubes through SIRT1-PPARα pathway
    Guglielmo Duranti, Mariateresa Maldini, Domenico Crognale, Stefania Sabatini, Federica Corana, Katy Horner, Roberta Ceci
    Phytomedicine Plus.2021; 1(1): 100014.     CrossRef
  • Diabetes risk associated with plasma epoxylipid levels
    John D. Imig
    eBioMedicine.2021; 66: 103331.     CrossRef
  • Genome-Wide Characterization of Alternative Splicing Events and Their Responses to Cold Stress in Tilapia
    Bi Jun Li, Zong Xian Zhu, Hui Qin, Zi Ning Meng, Hao Ran Lin, Jun Hong Xia
    Frontiers in Genetics.2020;[Epub]     CrossRef
  • PPARγ provides anti-inflammatory and protective effects in intrahepatic cholestasis of pregnancy through NF-κB pathway
    Yan Zhang, Xiaoping Huang, Jie Zhou, Yongxiang Yin, Ting Zhang, Daozhen Chen
    Biochemical and Biophysical Research Communications.2018; 504(4): 834.     CrossRef
  • Fermented Ginseng Contains an Agonist of Peroxisome Proliferator Activated Receptors α and γ
    Kentaro Igami, Yosuke Shimojo, Hisatomi Ito, Toshitsugu Miyazaki, Fusako Nakano, Yoshiki Kashiwada
    Journal of Medicinal Food.2016; 19(9): 817.     CrossRef
  • Long-term oral administration of osteocalcin induces insulin resistance in male mice fed a high-fat, high-sucrose diet
    Yu Yasutake, Akiko Mizokami, Tomoyo Kawakubo-Yasukochi, Sakura Chishaki, Ichiro Takahashi, Hiroshi Takeuchi, Masato Hirata
    American Journal of Physiology-Endocrinology and Metabolism.2016; 310(8): E662.     CrossRef
  • Peroxisome Proliferator-Activated Receptor-γGene Expression and Its Association with Oxidative Stress in Patients with Metabolic Syndrome
    Mehdi Hatami, Massoud Saidijam, Reza Yadegarzari, Shiva Borzuei, Alireza Soltanian, Marzieh Safi Arian, Mohammad Taghi Goodarzi
    Chonnam Medical Journal.2016; 52(3): 201.     CrossRef
  • Short Exposure to a High-Sucrose Diet and the First ‘Hit' of Nonalcoholic Fatty Liver Disease in Mice
    Flavia Fernandes-Lima, Thiago Luís Ribeiro Gomes Monte, Fernanda Amorim de Morais Nascimento, Bianca Martins Gregório
    Cells Tissues Organs.2016; 201(6): 464.     CrossRef
  • In vitro evaluation of dual agonists for PPARγ/β from the flower of Edgeworthia gardneri (wall.) Meisn
    Die Gao, Yong-lan Zhang, Pan Xu, Ye-xin Lin, Feng-qing Yang, Jian-hui Liu, Hai-wen Zhu, Zhi-ning Xia
    Journal of Ethnopharmacology.2015; 162: 14.     CrossRef
  • PPARα Agonist Fenofibrate Ameliorates Learning and Memory Deficits in Rats Following Global Cerebral Ischemia
    Ai-Guo Xuan, Yan Chen, Da-Hong Long, Meng Zhang, Wei-Dong Ji, Wen-Juan Zhang, Ji-Hong Liu, Le-Peng Hong, Xiao-Song He, Wen-Liang Chen
    Molecular Neurobiology.2015; 52(1): 601.     CrossRef
  • Modulation of Cardiac Connexin-43 by Omega-3 Fatty Acid Ethyl-Ester Supplementation Demonstrated in Spontaneously Diabetic Rats
    Physiological Research.2015; : 795.     CrossRef
  • Does Bosentan Protect Diabetic Brain Alterations in Rats? The Role of Endothelin‐1 in the Diabetic Brain
    Recep Demir, Elif Cadirci, Erol Akpinar, Yasemin Cayir, Hasan Tarik Atmaca, Harun Un, Celalettin Semih Kunak, Muhammed Yayla, Zafer Bayraktutan, Ilknur Demir
    Basic & Clinical Pharmacology & Toxicology.2015; 116(3): 236.     CrossRef
  • The effect of pioglitazone on aldosterone and cortisol production in HAC15 human adrenocortical carcinoma cells
    Zhi-qiang Pan, Ding Xie, Vivek Choudhary, Mutsa Seremwe, Ying-Ying Tsai, Lawrence Olala, Xunsheng Chen, Wendy B. Bollag
    Molecular and Cellular Endocrinology.2014; 394(1-2): 119.     CrossRef
  • Icariin Is A PPARα Activator Inducing Lipid Metabolic Gene Expression in Mice
    Yuan-Fu Lu, Yun-Yan Xu, Feng Jin, Qin Wu, Jing-Shan Shi, Jie Liu
    Molecules.2014; 19(11): 18179.     CrossRef
  • Canola Oil Influence on Azoxymethane-induced Colon Carcinogenesis, Hypertriglyceridemia and Hyperglycemia in Kunming Mice
    Xiao-Qiong He, Simon Angelo Cichello, Jia-Li Duan, Jin Zhou
    Asian Pacific Journal of Cancer Prevention.2014; 15(6): 2477.     CrossRef
  • Cardiovascular risks and benefits with oral drugs for Type 2 diabetes mellitus
    Emily Weidman-Evans, Steven M Metz, Jeffery D Evans
    Expert Review of Clinical Pharmacology.2014; 7(2): 225.     CrossRef
  • Enhanced pan‐peroxisome proliferator‐activated receptor gene and protein expression in adipose tissue of diet‐induced obese mice treated with telmisartan
    Aline Penna‐de‐Carvalho, Francielle Graus‐Nunes, Júlia Rabelo‐Andrade, Carlos Alberto Mandarim‐de‐Lacerda, Vanessa Souza‐Mello
    Experimental Physiology.2014; 99(12): 1663.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal