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Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals
Heung Yong Jin, Seong-Su Moon, Nigel A. Calcutt
Diabetes Metab J. 2021;45(1):27-42.   Published online December 15, 2020
DOI: https://doi.org/10.4093/dmj.2020.0216
  • 8,566 View
  • 228 Download
  • 13 Web of Science
  • 12 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
The worldwide diabetes epidemic is estimated to currently afflict almost 500 million persons. Long-term diabetes damages multiple organ systems with the blood vessels, eyes, kidneys and nervous systems being particularly vulnerable. These complications of diabetes reduce lifespan, impede quality of life and impose a huge social and economic burden on both the individual and society. Peripheral neuropathy is a debilitating complication that will impact over half of all persons with diabetes. There is no treatment for diabetic neuropathy and a disturbingly long history of therapeutic approaches showing promise in preclinical studies but failing to translate to the clinic. These failures have prompted re-examination of both the animal models and clinical trial design. This review focuses on the functional and structural parameters used as indices of peripheral neuropathy in preclinical and clinical studies and the extent to which they share a common pathogenesis and presentation. Nerve conduction studies in large myelinated fibers have long been the mainstay of preclinical efficacy screening programs and clinical trials, supplemented by quantitative sensory tests. However, a more refined approach is emerging that incorporates measures of small fiber density in the skin and cornea alongside these traditional assays at both preclinical and clinical phases.

Citations

Citations to this article as recorded by  
  • Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options
    Raffaele Galiero, Alfredo Caturano, Erica Vetrano, Domenico Beccia, Chiara Brin, Maria Alfano, Jessica Di Salvo, Raffaella Epifani, Alessia Piacevole, Giuseppina Tagliaferri, Maria Rocco, Ilaria Iadicicco, Giovanni Docimo, Luca Rinaldi, Celestino Sardu, T
    International Journal of Molecular Sciences.2023; 24(4): 3554.     CrossRef
  • Bidirectional association between diabetic peripheral neuropathy and vitamin B12 deficiency: Two longitudinal 9-year follow-up studies using a national sample cohort
    Heung Yong Jin, Kyung Ae Lee, Yu Ji Kim, In Sun Gwak, Tae Sun Park, Sang Woo Yeom, Jong Seung Kim
    Primary Care Diabetes.2023; 17(5): 436.     CrossRef
  • Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
    Harish Bhardwaj, Sulekha Khute, Ram Sahu, Rajendra Kumar Jangde
    Current Drug Targets.2023; 24(16): 1239.     CrossRef
  • A Real-World Analysis of High-Frequency 10 kHz Spinal Cord Stimulation for the Treatment of Painful Diabetic Peripheral Neuropathy
    Jeffrey L. Chen, Andrew W. Hesseltine, Sara E. Nashi, Shawn M. Sills, Tory L. McJunkin, Sandeep Patil, Manish Bharara, David L. Caraway, Elizabeth S. Brooks
    Journal of Diabetes Science and Technology.2022; 16(2): 282.     CrossRef
  • Using Corneal Confocal Microscopy to Identify Therapeutic Agents for Diabetic Neuropathy
    Corinne G. Jolivalt, May Madi Han, Annee Nguyen, Fiona Desmond, Carlos Henrique Alves Jesus, Daniela C. Vasconselos, Andrea Pedneault, Natalie Sandlin, Sage Dunne-Cerami, Katie E. Frizzi, Nigel A. Calcutt
    Journal of Clinical Medicine.2022; 11(9): 2307.     CrossRef
  • Glycyrrhizic acid promotes sciatic nerves recovery in type 1 diabetic rats and protects Schwann cells from high glucose-induced cytotoxicity
    Min Shi, Xiangcheng Zhang, Ridong Zhang, Hong Zhang, Dalong Zhu, Xiao Han
    The Journal of Biomedical Research.2022; 36(3): 181.     CrossRef
  • Novel mechanisms of pain in painful diabetic neuropathy
    Rayaz A. Malik
    Nature Reviews Endocrinology.2022; 18(8): 459.     CrossRef
  • An induced pluripotent stem cell-based model identifies molecular targets of vincristine neurotoxicity
    Neng-Wei Tsai, Cheng-Chen Lin, Ti-Yen Yeh, Yu-An Chiu, Hsin-Hui Chiu, Hsiang-Po Huang, Sung-Tsang Hsieh
    Disease Models & Mechanisms.2022;[Epub]     CrossRef
  • Corneal Confocal Microscopy: A Biomarker for Diabetic Peripheral Neuropathy
    Ioannis N. Petropoulos, Georgios Ponirakis, Maryam Ferdousi, Shazli Azmi, Alise Kalteniece, Adnan Khan, Hoda Gad, Bilal Bashir, Andrew Marshall, Andrew J.M. Boulton, Handrean Soran, Rayaz A. Malik
    Clinical Therapeutics.2021; 43(9): 1457.     CrossRef
  • Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals (Diabetes Metab J 2021;45:27-42)
    Otto Jesus Hernandez Fustes
    Diabetes & Metabolism Journal.2021; 45(3): 452.     CrossRef
  • Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals (Diabetes Metab J 2021;45:27-42)
    Heung Yong Jin, Seong-Su Moon, Nigel A. Calcutt
    Diabetes & Metabolism Journal.2021; 45(3): 457.     CrossRef
  • Sterculia tragacantha Lindl Leaf Extract Ameliorates STZ-Induced Diabetes, Oxidative Stress, Inflammation and Neuronal Impairment
    Amos Sunday Onikanni, Bashir Lawal, Augustine O Olusola, Janet O Olugbodi, Saidu Sani, Basiru Olaitan Ajiboye, Omotayo B Ilesanmi, Mohammed Alqarni, Gomaa Mostafa-Hedeab, Ahmad J Obaidullah, Gaber El-Saber Batiha, Alexander TH Wu
    Journal of Inflammation Research.2021; Volume 14: 6749.     CrossRef
Current Status of Diabetic Peripheral Neuropathy in Korea: Report of a Hospital-Based Study of Type 2 Diabetic Patients in Korea by the Diabetic Neuropathy Study Group of the Korean Diabetes Association
Jong Chul Won, Sang Soo Kim, Kyung Soo Ko, Bong-Yun Cha
Diabetes Metab J. 2014;38(1):25-31.   Published online February 19, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.1.25
  • 3,938 View
  • 52 Download
  • 28 Web of Science
  • 27 Crossref
AbstractAbstract PDFPubReader   

Diabetic peripheral neuropathy (DPN) is the most common complication associated with diabetes. DPN can present as a loss of sensation, may lead to neuropathic ulcers, and is a leading cause of amputation. Reported estimates of the prevalence of DPN vary due to differences in study populations and diagnostic criteria. Furthermore, the epidemiology and clinical characteristics of DPN in Korean patients with type 2 diabetes mellitus (T2DM) are not as well understood as those of other complications of diabetes such as retinal and renal disease. Recently, the Diabetic Neuropathy Study Group of the Korean Diabetes Association (KDA) conducted a study investigating the impact of DPN on disease burden and quality of life in patients with T2DM and has published some data that are representative of the nation. This review investigated the prevalence and associated clinical implications of DPN in Korean patients with diabetes based on the KDA study.

Citations

Citations to this article as recorded by  
  • Shear wave elastography of tibial nerve in patients with diabetic peripheral neuropathy—A cross-sectional study
    Dhiri Ranjan Pradhan, Sudhir Saxena, Ravi Kant, Mirtunjai Kumar, Sonal Saran
    Skeletal Radiology.2024; 53(3): 547.     CrossRef
  • Diabetic peripheral neuropathy: age-stratified glycemic control
    Chi-Sheng Wang, Yen-Wei Pai, Ching-Heng Lin, I-Te Lee, Hsiao-Hui Chen, Ming-Hong Chang
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Association of Sensory Nerve Action Potential Amplitude and Velocity With Type 2 Diabetic Peripheral Neuropathy
    Anwar H Siddiqui, Nazia Tauheed, Hamid Ashraf, Jamal Ahmad
    Cureus.2023;[Epub]     CrossRef
  • A review on extraction, purification, structural characteristics and bioactivities of polysaccharides from Polygonatum odoratum (Mill.) Druce
    Xin-Yan Zong, De-Chang Xu, Jun-Yi Yin, Shao-Ping Nie, Ming-Yong Xie
    Bioactive Carbohydrates and Dietary Fibre.2022; 27: 100284.     CrossRef
  • Development and characterisation of a rat model that exhibits both metabolic dysfunction and neurodegeneration seen in type 2 diabetes
    Katherine Southam, Chantal de Sousa, Abraham Daniel, Bruce V. Taylor, Lisa Foa, Dino Premilovac
    The Journal of Physiology.2022; 600(7): 1611.     CrossRef
  • Renal impairment is one of appropriate predictors of future diabetic peripheral neuropathy: a hospital-based 6-year follow-up study
    Chi-Sheng Wang, Yen-Wei Pai, Ching-Heng Lin, I-Te Lee, Ming-Hong Chang
    Scientific Reports.2022;[Epub]     CrossRef
  • Pathogenesis and Treatment of Diabetic Peripheral Neuropathy
    Seon Mee Kang
    The Journal of Korean Diabetes.2022; 23(4): 222.     CrossRef
  • Compound XiongShao Capsule ameliorates streptozotocin-induced diabetic peripheral neuropathy in rats via inhibiting apoptosis, oxidative - nitrosative stress and advanced glycation end products
    Mei-xiang Yu, Bo Lei, Xin Song, Yong-mei Huang, Xiao-qin Ma, Chen-xia Hao, Wan-hua Yang, Man-li Pan
    Journal of Ethnopharmacology.2021; 268: 113560.     CrossRef
  • Etiology, diagnosis, complications, and treatments of diabetic foot
    Dong-Kyo Seo
    Journal of the Korean Medical Association.2021; 64(8): 523.     CrossRef
  • A nationwide study of patients with monoclonal gammopathy of undetermined significance with a 10-year follow-up in South Korea
    Ka-Won Kang, Ji Eun Song, Byung-Hyun Lee, Min Ji Jeon, Eun Sang Yu, Dae Sik Kim, Se Ryeon Lee, Hwa Jung Sung, Chul Won Choi, Yong Park, Byung Soo Kim
    Scientific Reports.2021;[Epub]     CrossRef
  • Acupuncture for diabetic peripheral neuropathy: study protocol for a randomized, placebo-controlled trial
    Haiping Deng, Yu Shu, Peiran Lv, Ling Zhao, Ke Cheng, Tingting Zhang, Yi Song, Hua Yang, Hong Tang, Jian Pei, Xueyong Shen
    Trials.2020;[Epub]     CrossRef
  • Identify the Key Active Ingredients and Pharmacological Mechanisms of Compound XiongShao Capsule in Treating Diabetic Peripheral Neuropathy by Network Pharmacology Approach
    Meixiang Yu, Xin Song, Wanhua Yang, Ziwei Li, Xiaoqin Ma, Chenxia Hao
    Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1.     CrossRef
  • Deep phenotyping neuropathy: An underestimated complication in patients with pre-diabetes and type 2 diabetes associated with albuminuria
    Stefan Kopf, Jan B. Groener, Zoltan Kender, Thomas Fleming, Sandra Bischoff, Johann Jende, Carsten Schumann, Stefan Ries, Martin Bendszus, Sigrid Schuh-Hofer, Rolf-Detlef Treede, Peter P. Nawroth
    Diabetes Research and Clinical Practice.2018; 146: 191.     CrossRef
  • Role of neopterin as a biochemical marker for peripheral neuropathy in pediatric patients with type 1 diabetes: Relation to nerve conduction studies
    Nancy Samir Elbarbary, Eman Abdel Rahman Ismail, Rana Ahmed El-Hilaly, Fatma Salama Ahmed
    International Immunopharmacology.2018; 59: 68.     CrossRef
  • Association between diabetic peripheral neuropathy and heart rate variability in subjects with type 2 diabetes
    S.K.M. Azizul Islam, Dongkyu Kim, Young-Sil Lee, Seong-Su Moon
    Diabetes Research and Clinical Practice.2018; 140: 18.     CrossRef
  • Diagnosis and Management of Diabetic Peripheral Neuropathy
    Seong-Su Moon
    The Journal of Korean Diabetes.2018; 19(3): 153.     CrossRef
  • Clinical Importance of Diabetic Neuropathy
    Tae Sun Park
    The Journal of Korean Diabetes.2018; 19(3): 147.     CrossRef
  • The U-shaped relationship between fibroblast growth factor 21 and microvascular complication in type 2 diabetes mellitus
    Chan-Hee Jung, Sang-Hee Jung, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
    Journal of Diabetes and its Complications.2017; 31(1): 134.     CrossRef
  • Retinal Neurodegeneration Associated With Peripheral Nerve Conduction and Autonomic Nerve Function in Diabetic Patients
    Kiyoung Kim, Seung-Young Yu, Hyung Woo Kwak, Eung Suk Kim
    American Journal of Ophthalmology.2016; 170: 15.     CrossRef
  • Letter: Cardiovascular Disease Predicts Severe Hypoglycemia in Patients with Type 2 Diabetes (Diabetes Metab J 2015;39:498-506)
    Mi-Kyung Kim
    Diabetes & Metabolism Journal.2016; 40(1): 83.     CrossRef
  • Associations of serum anti-ganglioside antibodies and inflammatory markers in diabetic peripheral neuropathy
    Shengjie Ge, Jing Xie, Lequn Zheng, Lijuan Yang, Hong Zhu, Xingbo Cheng, Feixia Shen
    Diabetes Research and Clinical Practice.2016; 115: 68.     CrossRef
  • Axonopathy in peripheral neuropathies: Mechanisms and therapeutic approaches for regeneration
    Lila M. Landowski, P. James B. Dyck, JaNean Engelstad, Bruce V. Taylor
    Journal of Chemical Neuroanatomy.2016; 76: 19.     CrossRef
  • Adiponectin gene polymorphisms are associated with increased susceptibility to diabetic peripheral neuropathy
    Yao Chen, Jian Wang, Lijing Wang, Peiji Huang, Zeng-Xian Tan, Huai-Jun Liu
    Biomarkers.2015; 20(6-7): 474.     CrossRef
  • Effect of Socio-Economic Status on the Prevalence of Diabetes
    Yu Jeong Kim, Ja Young Jeon, Seung Jin Han, Hae Jin Kim, Kwan Woo Lee, Dae Jung Kim
    Yonsei Medical Journal.2015; 56(3): 641.     CrossRef
  • Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy
    Heung Yong Jin, Hong Sun Baek, Tae Sun Park
    Diabetes & Metabolism Journal.2015; 39(6): 461.     CrossRef
  • Diabetic neuropathy and the sensory apparatus “meissner corpuscle and merkel cells”
    Salma Alsunousi, Husnia I. Marrif
    Frontiers in Neuroanatomy.2014;[Epub]     CrossRef
  • Arterial Stiffness and Carotid Intima-Media Thickness in Diabetic Peripheral Neuropathy
    Bulent Behlul Altunkeser
    Medical Science Monitor.2014; 20: 2074.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal