Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
7 "Intra-abdominal fat"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Articles
Metabolic Risk/Epidemiology
Article image
Novel Asian-Specific Visceral Adiposity Indices Are Associated with Chronic Kidney Disease in Korean Adults
Jonghwa Jin, Hyein Woo, Youngeun Jang, Won-Ki Lee, Jung-Guk Kim, In-Kyu Lee, Keun-Gyu Park, Yeon-Kyung Choi
Diabetes Metab J. 2023;47(3):426-436.   Published online March 6, 2023
DOI: https://doi.org/10.4093/dmj.2022.0099
  • 3,902 View
  • 161 Download
  • 5 Web of Science
  • 5 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
The Chinese visceral adiposity index (CVAI) and new visceral adiposity index (NVAI) are novel indices of visceral adiposity used to predict metabolic and cardiovascular diseases in Asian populations. However, the relationships of CVAI and NVAI with chronic kidney disease (CKD) have not been investigated. We aimed to characterize the relationships of CVAI and NVAI with the prevalence of CKD in Korean adults.
Methods
A total of 14,068 participants in the 7th Korea National Health and Nutrition Examination Survey (6,182 men and 7,886 women) were included. Receiver operating characteristic (ROC) analyses were employed to compare the associations between indices of adiposity and CKD, and a logistic regression model was used to characterize the relationships of CVAI and NVAI with CKD prevalence.
Results
The areas under the ROC curves for CVAI and NVAI were significantly larger than for the other indices, including the visceral adiposity index and lipid accumulation product, in both men and women (all P<0.001). In addition, high CVAI or NVAI was significantly associated with a high CKD prevalence in both men (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.31 to 3.48 in CVAI and OR, 6.47; 95% CI, 2.91 to 14.38 in NVAI, P<0.05) and women (OR, 4.87; 95% CI, 1.85 to 12.79 in CVAI and OR, 3.03; 95% CI, 1.35 to 6.82 in NVAI, P<0.05); this association remained significant after adjustment for multiple confounding factors in men and women.
Conclusion
CVAI and NVAI are positively associated with CKD prevalence in a Korean population. CVAI and NVAI may be useful for the identification of CKD in Asian populations, including in Korea.

Citations

Citations to this article as recorded by  
  • Accessing the relationship between six surrogate insulin resistance indexes and the incidence of rapid kidney function decline and the progression to chronic kidney disease among middle-aged and older adults in China: Results from the China health and ret
    Siti Liu, Honglin Sun, Jia Liu, Guang Wang
    Diabetes Research and Clinical Practice.2024; 212: 111705.     CrossRef
  • Association between visceral adiposity index and incidence of diabetic kidney disease in adults with diabetes in the United States
    Chunyao Li, Gang Wang, Jiale Zhang, Weimin Jiang, Shuwu Wei, Wenna Wang, Shuyv Pang, Chenyv Pan, Weiwei Sun
    Scientific Reports.2024;[Epub]     CrossRef
  • Association between lipid accumulation product index and chronic kidney disease: A systematic review and meta-analysis
    Feixiang Wu, Chenmin Cui, Junping Wu, Yunqing Wang
    Experimental and Therapeutic Medicine.2024;[Epub]     CrossRef
  • Linear associations of Chinese visceral adiposity index and its change with hyperuricemia: A prospective cohort study
    Jia Chen, Xuejiao Liu, Shuai Lu, Siliang Man, Liang Zhang, Xiaojie Xu, Wei Deng, Xieyuan Jiang
    Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(11): 2472.     CrossRef
  • Association between Chinese visceral adiposity index and risk of stroke incidence in middle-aged and elderly Chinese population: evidence from a large national cohort study
    Zenglei Zhang, Lin Zhao, Yiting Lu, Xu Meng, Xianliang Zhou
    Journal of Translational Medicine.2023;[Epub]     CrossRef
Metabolic Risk/Epidemiology
Article image
Sex Differences of Visceral Fat Area and Visceral-to-Subcutaneous Fat Ratio for the Risk of Incident Type 2 Diabetes Mellitus
Eun Hee Kim, Hong-Kyu Kim, Min Jung Lee, Sung-Jin Bae, Jaewon Choe, Chang Hee Jung, Chul-Hee Kim, Joong-Yeol Park, Woo Je Lee
Diabetes Metab J. 2022;46(3):486-498.   Published online November 18, 2021
DOI: https://doi.org/10.4093/dmj.2021.0095
  • 13,224 View
  • 423 Download
  • 30 Web of Science
  • 36 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
This study aimed to determine the optimal cut-off values of visceral fat area (VFA) and visceral-to-subcutaneous fat ratio (VSR) for predicting incident type 2 diabetes mellitus (T2DM).
Methods
A total of 10,882 individuals (6,835 men; 4,047 women) free of T2DM at baseline aged between 30 and 79 years who underwent abdominal computed tomography scan between 2012 and 2013 as a part of routine health check-ups were included and followed. VFA, subcutaneous fat area, and VSR on L3 vertebral level were measured at baseline.
Results
During a median follow-up of 4.8 years, 730 (8.1% for men; 4.3% for women) incident cases of T2DM were identified. Receiver operating characteristic curve analysis showed that the optimal cut-off values of VFA and VSR for predicting incident T2DM were 130.03 cm2 and 1.08 in men, respectively, and 85.7 cm2 and 0.48 in women, respectively. Regardless of sex, higher VFA and VSR were significantly associated with a higher risk of incident T2DM. Compared with the lowest quartiles of VFA and VSR, the highest quartiles had adjusted odds ratios of 2.62 (95% confidence interval [CI], 1.73 to 3.97) and 1.55 (95% CI, 1.14 to 2.11) in men, respectively, and 32.49 (95% CI, 7.42 to 142.02) and 11.07 (95% CI, 3.89 to 31.50) in women, respectively.
Conclusion
Higher VFA and VSR at baseline were independent risk factors for the development of T2DM. Sex-specific reference values for visceral fat obesity (VFA ≥130 cm2 or VSR ≥1.0 in men; VFA ≥85 cm2 or VSR ≥0.5 in women) are proposed for the prediction of incident T2DM.

Citations

Citations to this article as recorded by  
  • Severity of adipose tissue dysfunction is associated with progression of pre-diabetes to type 2 diabetes: the Tehran Lipid and Glucose Study
    Mohammad Jalali, Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi, Farhad Hosseinpanah
    BMC Public Health.2024;[Epub]     CrossRef
  • Should insulin resistance (HOMA-IR), insulin secretion (HOMA-β), and visceral fat area be considered for improving the performance of diabetes risk prediction models
    Huan Hu, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Tetsuya Mizoue
    BMJ Open Diabetes Research & Care.2024; 12(1): e003680.     CrossRef
  • Adipose organ dysfunction and type 2 diabetes: Role of nitric oxide
    Zahra Bahadoran, Parvin Mirmiran, Asghar Ghasemi
    Biochemical Pharmacology.2024; 221: 116043.     CrossRef
  • Prediction of high visceral adipose tissue for sex‐specific community residents in Taiwan
    Yu‐Hsuan Chang, Chin‐Sung Chang, Chieh‐Yu Liu, Yin‐Fan Chang, Shiow‐Ching Shun
    Nursing & Health Sciences.2024;[Epub]     CrossRef
  • Guidelines for obesity clinic consultations in primary healthcare clinics
    Jee-Hyun Kang, Kyoung-Kon Kim
    Journal of the Korean Medical Association.2024; 67(4): 240.     CrossRef
  • Correlation between fat-to-muscle mass ratio and cognitive impairment in elderly patients with type 2 diabetes mellitus: a cross-sectional study
    Fan Wu, Yanlan Liu, Chenying Lin, Nahal Haghbin, Longfei Xia, Yaoshuang Li, Tong Chen, Huina Qiu, Weiran Jiang, Jingbo Li, Jingna Lin
    BMC Geriatrics.2024;[Epub]     CrossRef
  • Evaluation of visceral adipose tissue thresholds for elevated metabolic syndrome risk across diverse populations: A systematic review
    Jonathan P. Bennett, Carla M. Prado, Steven B. Heymsfield, John A. Shepherd
    Obesity Reviews.2024;[Epub]     CrossRef
  • Establishment of a novel weight reduction model after laparoscopic sleeve gastrectomy based on abdominal fat area
    Tianyi Feng, Sanyuan Hu, Changrong Song, Mingwei Zhong
    Frontiers in Surgery.2024;[Epub]     CrossRef
  • Combined associations of visceral adipose tissue and adherence to a Mediterranean lifestyle with T2D and diabetic microvascular complications among individuals with prediabetes
    Hao-Wen Chen, Kuan Liu, Bi-Fei Cao, Qi Zhong, Rui Zhou, Liang-Hua Li, Shi-Ao Wang, Yan-Fei Wei, Hua-Min Liu, Xian-Bo Wu
    Cardiovascular Diabetology.2024;[Epub]     CrossRef
  • Visceral fat area and subcutaneous fat area as measures of body composition in soft tissue sarcoma
    Eric Robles Garibay, Sylvia M. Cruz, Sean J. Judge, Arta M. Monjazeb, Steven W. Thorpe, William J. Murphy, Jing Lyu, Shuai Chen, Cyrus P. Bateni, Robert J. Canter
    Journal of Surgical Oncology.2024; 130(3): 543.     CrossRef
  • Visceral to subcutaneous fat area ratio predicts severe abdominal adhesions in definitive surgery for anastomotic fistula after small intestine resection
    Fan Yang, Weiliang Tian, Shikun Luo, Wuhan Li, Guoping Zhao, Risheng Zhao, Tao Tian, Yunzhao Zhao, Zheng Yao, Qian Huang
    Scientific Reports.2024;[Epub]     CrossRef
  • Assessing Patients beyond the Simple Optics of BMI: The Concomitant Role of Sarcopenia and BMI in Predicting Kidney Transplant Outcomes
    Christopher Seet, Laura Clementoni, Mohammed Rashid Akhtar, Pankaj Chandak, Mohammed Saoud, Amr Elsaadany, Muhammad Magdi Yaqoob, Ismail Heyder Mohamed, Muhammad Arslan Khurram
    Life.2024; 14(8): 1036.     CrossRef
  • Serum immunoglobulin A levels: Diagnostic utility in alcoholic liver disease and association with liver fibrosis in steatotic liver disease
    Tatsuki Ichikawa, Mio Yamashima, Shinobu Yamamichi, Makiko Koike, Yusuke Nakano, Hiroyuki Yajima, Osamu Miyazaki, Tomonari Ikeda, Takuma Okamura, Kazuyoshi Nagata, Kenichi Sawa, Kazutaka Niiya, Kazuhiko Nakao
    Biomedical Reports.2024;[Epub]     CrossRef
  • Myosteatosis Predicts Bariatric Surgery Response: A Longitudinal Study in Patients With Morbid Obesity
    Eugene Han, Mi Kyung Kim, Hye Won Lee, Seungwan Ryu, Hye Soon Kim, Byoung Kuk Jang, Youngsung Suh
    The Journal of Clinical Endocrinology & Metabolism.2024;[Epub]     CrossRef
  • Body composition as a potential imaging biomarker for predicting the progression risk of chronic kidney disease
    Zhouyan Liao, Guanjie Yuan, Kangwen He, Shichao Li, Mengmeng Gao, Ping Liang, Chuou Xu, Qian Chu, Min Han, Zhen Li
    Insights into Imaging.2024;[Epub]     CrossRef
  • Visceral Obesity and Its Association with Severe Coronary Artery Calcification in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease
    Min Kyu Kang, Jeung Eun Song, Young Oh Kweon, Won Young Tak, Soo Young Park, Yu Rim Lee, Jung Gil Park
    Diagnostics.2024; 14(20): 2305.     CrossRef
  • Gender Differences of Visceral Fat Area to Hip Circumference Ratio for Insulin Resistance
    Huiying Cao, Xuan Huang, Beibei Luo, Wei Shi, Huan Li, Rui Shi
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 3935.     CrossRef
  • Microarray Analysis of Visceral Adipose Tissue in Obese Women Reveals Common Crossroads Among Inflammation, Metabolism, Addictive Behaviors, and Cancer
    Rolando Martínez-Romero, Susana Aideé González-Chávez, Victor Roberto Urías-Rubí, Víctor Manuel Gómez-Moreno, Manlio Favio Blanco-Cantero, Héctor Mario Bernal-Velázquez, Arturo Luévano-González, César Pacheco-Tena, Claire Stocker
    Journal of Obesity.2024;[Epub]     CrossRef
  • Sex differences of visceral fat with cardiac structure and function in type 2 diabetes: A cross‐sectional study
    Chen Rui‐hua, Lin Yi, Xu Huan‐bai, Wang Yu‐fan, Peng Yong‐de
    Journal of Diabetes.2024;[Epub]     CrossRef
  • Body fat variation and redistribution across different stages of life measured by dual-energy x-ray absorptiometry
    Hongbo Dong, Hong Cheng, Jingfan Xiong, Li Liu, Yiwen Huang, Xinying Shan, Hongmin Fan, Xi Wang, Xia Wang, Pei Xiao, Fangfang Chen, Jie Mi
    Journal of Global Health.2024;[Epub]     CrossRef
  • Body Composition and Metabolic Dysfunction Really Matter for the Achievement of Better Outcomes in High-Grade Serous Ovarian Cancer
    Mauricio A. Cuello, Fernán Gómez, Ignacio Wichmann, Felipe Suárez, Sumie Kato, Elisa Orlandini, Jorge Brañes, Carolina Ibañez
    Cancers.2023; 15(4): 1156.     CrossRef
  • MEDICINAL BIOMAGNETISM FOR THE TREATMENT OF OBESITY
    Ana Vergínia Campagnollo Bueno, Michelli Gonçalves Seneda, Ângela Mara Rambo, Ana Clara Campagnolo Gonçalves Toledo, Caroline Cabral de Azevedo, Adriane Viapiana Bossa
    Health and Society.2023; 3(01): 411.     CrossRef
  • Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes
    Min-Kyung Lee, Jae-Hyuk Lee, Seo Young Sohn, Jiyeon Ahn, Oak-Kee Hong, Mee-Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Kyungdo Han, Hyuk-Sang Kwon
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • The correlation between visceral fat/subcutaneous fat area ratio and monocyte/high-density lipoprotein ratio in patients with type 2 diabetes mellitus and albuminuria
    Haiyan Lin, Jun Zhu, Chen Zheng, Xiaoming Xu, Shandong Ye
    Journal of Diabetes and its Complications.2023; 37(11): 108521.     CrossRef
  • Effects of the abdominal fat distribution on the relationship between exposure to air pollutants and thyroid hormones among Korean adult males
    Hyun-Jin Kim, Byungmi Kim, Seyoung Kim, Hyuktae Kwon, Jae Moon Yun, Belong Cho, Jin-Ho Park
    European Journal of Medical Research.2023;[Epub]     CrossRef
  • Association of Visceral Fat Obesity, Sarcopenia, and Myosteatosis with Non-Alcoholic Fatty Liver Disease without Obesity
    Hong-Kyu Kim, Sung-Jin Bae, Min Jung Lee, Eun Hee Kim, Hana Park, Hwi Seung Kim, Yun Kyung Cho, Chang Hee Jung, Woo Je Lee, Jaewon Choe
    Clinical and Molecular Hepatology.2023; 29(4): 987.     CrossRef
  • Visceral adipose tissue reference data computed for GE HealthCare DXA from the National Health and Nutrition Examination Survey data set
    Jonathan P. Bennett, Brandon K. Quon, Bo Fan, En Liu, Leila Kazemi, Rosa C. Villegas‐Valle, Raj Ahgun, Xian‐pin Wu, Hou‐De Zhou, Ying Lu, John A. Shepherd
    Obesity.2023; 31(12): 2947.     CrossRef
  • Comparison of bioelectrical body and visceral fat indices and anthropometric measures in relation to type 2 diabetes by sex among Chinese adults, a cross-sectional study
    Jiangshan He, Binbin Zhang, Yaqi Fan, Yuxue Wang, Mianzhi Zhang, Chunjun Li, Li Zhang, Pei Guo, Minying Zhang
    Frontiers in Public Health.2023;[Epub]     CrossRef
  • The predictive significance of lipid accumulation products for future diabetes in a non-diabetic population from a gender perspective: an analysis using time-dependent receiver operating characteristics
    Jiajun Qiu, Maobin Kuang, Yang Zou, Ruijuan Yang, Qing Shangguan, Dingyang Liu, Guotai Sheng, Wei Wang
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy
    Ren Jie Phang, Rebecca H. Ritchie, Derek J. Hausenloy, Jarmon G. Lees, Shiang Y. Lim
    Cardiovascular Research.2022;[Epub]     CrossRef
  • Implication of Sex Differences in Visceral Fat for the Assessment of Incidence Risk of Type 2 Diabetes Mellitus
    Sang Hyeon Ju, Hyon-Seung Yi
    Diabetes & Metabolism Journal.2022; 46(3): 414.     CrossRef
  • Visceral fat area and body fat percentage measured by bioelectrical impedance analysis correlate with glycometabolism
    Shuying Li, Shaoping Li, Jie Ding, Weihong Zhou
    BMC Endocrine Disorders.2022;[Epub]     CrossRef
  • The Demographic Specific Abdominal Fat Composition and Distribution Trends in US Adults from 2011 to 2018
    Furong Xu, Jacob E. Earp, Bryan J. Blissmer, Ingrid E. Lofgren, Matthew J. Delmonico, Geoffrey W. Greene
    International Journal of Environmental Research and Public Health.2022; 19(19): 12103.     CrossRef
  • Visceral Obesity Is a More Important Factor for Colorectal Adenomas than Skeletal Muscle or Body Fat
    Ji Yeon Seo, Yoo Min Han, Su Jin Chung, Seon Hee Lim, Jung Ho Bae, Goh Eun Chung
    Cancers.2022; 14(21): 5256.     CrossRef
  • Recent Advances in Visceral Obesity and Related Diseases
    佳佳 魏
    Advances in Clinical Medicine.2022; 12(12): 11686.     CrossRef
  • Gender differences in the ideal cutoffs of visceral fat area for predicting MAFLD in China
    Pingping Yu, Huachao Yang, Xiaoya Qi, Ruixue Bai, Shouqin Zhang, Jianping Gong, Ying Mei, Peng Hu
    Lipids in Health and Disease.2022;[Epub]     CrossRef
Metabolic Risk/Epidemiology
Intra-Abdominal Fat and High Density Lipoprotein Cholesterol Are Associated in a Non-Linear Pattern in Japanese-Americans
Sun Ok Song, You-Cheol Hwang, Steven E. Kahn, Donna L. Leonetti, Wilfred Y. Fujimoto, Edward J. Boyko
Diabetes Metab J. 2020;44(2):277-285.   Published online March 10, 2020
DOI: https://doi.org/10.4093/dmj.2019.0008
  • 5,536 View
  • 74 Download
  • 4 Web of Science
  • 5 Crossref
AbstractAbstract PDFPubReader   
Background

We describe the association between high density lipoprotein cholesterol (HDL-C) concentration and computed tomography (CT)-measured fat depots.

Methods

We examined the cross-sectional associations between HDL-C concentration and intra-abdominal (IAF), abdominal subcutaneous (SCF), and thigh fat (TF) areas in 641 Japanese-American men and women. IAF, SCF, and TF were measured by CT at the level of the umbilicus and mid-thigh. The associations between fat area measurements and HDL-C were examined using multivariate linear regression analysis adjusting for age, sex, diabetes family history, homeostasis model assessment of insulin resistance (HOMA-IR), and body mass index (BMI). Non-linearity was assessed using fractional polynomials.

Results

Mean±standard deviation of HDL-C concentration and IAF in men and women were 1.30±0.34 mg/dL, 105±55.3 cm2, and 1.67±0.43 mg/dL, 74.4±46.6 cm2 and differed significantly by gender for both comparisons (P<0.001). In univariate analysis, HDL-C concentration was significantly associated with CT-measured fat depots. In multivariate analysis, IAF was significantly and non-linearly associated with HDL-C concentration adjusted for age, sex, BMI, HOMA-IR, SCF, and TF (IAF: β=−0.1012, P<0.001; IAF2: β=0.0008, P<0.001). SCF was also negatively and linearly associated with HDL-C (β=−0.4919, P=0.001).

Conclusion

HDL-C does not linearly decline with increasing IAF in Japanese-Americans. A more complex pattern better fits this association.

Citations

Citations to this article as recorded by  
  • Associations of Serum Uric Acid to High-Density Lipoprotein Cholesterol Ratio with Trunk Fat Mass and Visceral Fat Accumulation
    Yansu Wang, Yiting Xu, Tingting Hu, Yunfeng Xiao, Yufei Wang, Xiaojing Ma, Haoyong Yu, Yuqian Bao
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 121.     CrossRef
  • Impact of the COVID-19 Pandemic on Obesity, Metabolic Parameters and Clinical Values in the South Korean Adult Population
    Anna Kim, Eun-yeob Kim, Jaeyoung Kim
    Journal of Clinical Medicine.2024; 13(10): 2814.     CrossRef
  • Obesity-related parameters in carriers of some BDNF genetic variants may depend on daily dietary macronutrients intake
    Urszula Miksza, Edyta Adamska-Patruno, Witold Bauer, Joanna Fiedorczuk, Przemyslaw Czajkowski, Monika Moroz, Krzysztof Drygalski, Andrzej Ustymowicz, Elwira Tomkiewicz, Maria Gorska, Adam Kretowski
    Scientific Reports.2023;[Epub]     CrossRef
  • Computed tomography-based investigation of the correlation of abdominal fat areas with metabolic syndrome
    Kai-Yuan Cheng, Tsung-Hsien Yen, Jay Wu, Pei-Hsuan Li, Tian-Yu Shih
    Journal of Radiological Science.2023; 48(1): 15.     CrossRef
  • Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat
    Sun Ok Song, You-Cheol Hwang, Han Uk Ryu, Steven E. Kahn, Donna L. Leonetti, Wilfred Y. Fujimoto, Edward J. Boyko
    Endocrinology and Metabolism.2021; 36(4): 835.     CrossRef
Obesity and Metabolic Syndrome
Association between Blood Mercury Level and Visceral Adiposity in Adults
Jong Suk Park, Kyoung Hwa Ha, Ka He, Dae Jung Kim
Diabetes Metab J. 2017;41(2):113-120.   Published online December 21, 2016
DOI: https://doi.org/10.4093/dmj.2017.41.2.113
  • 6,156 View
  • 53 Download
  • 39 Web of Science
  • 40 Crossref
AbstractAbstract PDFPubReader   
Background

Few studies have examined the association between mercury exposure and obesity. The aim of this study is to investigate the association between blood mercury concentrations and indices of obesity in adults.

Methods

A total of 200 healthy subjects, aged 30 to 64 years, who had no history of cardiovascular or malignant disease, were examined. Anthropometric and various biochemical profiles were measured. Visceral adipose tissue (VAT) was measured using dual-energy X-ray absorptiometry (DXA).

Results

All subjects were divided into three groups according to blood mercury concentrations. Compared with the subjects in the lowest tertile of mercury, those in the highest tertile were more likely to be male; were current alcohol drinkers and smokers; had a higher body mass index (BMI), waist circumference (WC), and VAT; had higher levels of blood pressure, fasting glucose, and insulin resistance; and consumed more fish. The blood mercury concentration was significantly associated with anthropometric parameters, showing relationships with BMI, WC, and VAT. After adjusting for multiple risk factors, the odds ratios (ORs) for high mercury concentration was significantly higher in the highest VAT tertile than in the lowest VAT tertile (OR, 2.66; 95% confidence interval, 1.05 to 6.62; P<0.05).

Conclusion

The blood mercury concentration was significantly associated with VAT in healthy adults. Further studies are warranted to confirm our findings.

Citations

Citations to this article as recorded by  
  • Heavy Metal and Trace Element Status and Dietary Determinants in Children with Phenylketonuria
    İzzet Erdal, Yılmaz Yıldız, Siddika Songül Yalçın, Anıl Yirün, Deniz Arca Çakır, Pınar Erkekoğlu
    Nutrients.2024; 16(20): 3463.     CrossRef
  • Exposure to Metal Mixtures and Overweight or Obesity Among Chinese Adults
    Gaojie Fan, Qing Liu, Mingyang Wu, Jianing Bi, Xiya Qin, Qing Fang, Zhengce Wan, Yongman Lv, Youjie Wang, Lulu Song
    Biological Trace Element Research.2023; 201(8): 3697.     CrossRef
  • Methylmercury drives lipid droplet formation and adipokine expression during the late stages of adipocyte differentiation in 3T3-L1 cells
    Yasukazu Takanezawa, Yui Kashiwano, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono
    Toxicology.2023; 486: 153446.     CrossRef
  • Expression Profiling of Adipogenic and Anti-Adipogenic MicroRNA Sequences following Methylmercury Exposure in Caenorhabditis elegans
    Giancarlo Garofalo, Tyson Nielsen, Samuel Caito
    Toxics.2023; 11(11): 934.     CrossRef
  • Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the available evidence in relation to the potential obesogenic activity of certain chemical compounds that may be present in foods
    Ana María Rivas Velasco, Irene Bretón Lesmes, Araceli Díaz Perales, Ángel Gil Izquierdo, María José González Muñoz, Victoria Moreno Arribas, María del Puy Portillo Baquedano, Silvia Pichardo Sánchez
    Food Risk Assess Europe.2023;[Epub]     CrossRef
  • Lead, mercury, and cadmium exposures are associated with obesity but not with diabetes mellitus: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Min Kyong Moon, Inae Lee, Aram Lee, Hyunwoong Park, Min Joo Kim, Sunmi Kim, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Gi Jeong Cheon, Kyungho Choi, Young Joo Park, Jeongim Park
    Environmental Research.2022; 204: 111888.     CrossRef
  • The Effect of Mixture of Heavy Metals on Obesity in Individuals ≥50 Years of Age
    Hai Nguyen Duc, Hojin Oh, Min-Sun Kim
    Biological Trace Element Research.2022; 200(8): 3554.     CrossRef
  • MicroRNA Expression Influences Methylmercury-Induced Lipid Accumulation and Mitochondrial Toxicity in Caenorhabditis elegans
    Tyson Nielsen, Nicole Crawford, Megan Martell, Belal Khalil, Farooq Imtiaz, Jennifer L. Newell-Caito, Samuel Caito
    Chemical Research in Toxicology.2022; 35(1): 77.     CrossRef
  • Relationship Between Serum Levels of Arsenic, Cadmium, and Mercury and Body Mass Index and Fasting Plasma Glucose in a Mexican Adult Population
    Héctor Hernández-Mendoza, Héctor Edmundo Álvarez-Loredo, Elizabeth Teresita Romero-Guzmán, Darío Gaytán-Hernández, Consuelo Chang-Rueda, Israel Martínez-Navarro, Bertha Irene Juárez-Flores, María Judith Rios-Lugo
    Biological Trace Element Research.2022; 200(12): 4916.     CrossRef
  • Heavy metal-induced lipogenic gene aberration, lipid dysregulation and obesogenic effect: a review
    Yang Zhou, Frank Peprah Addai, Xinshuang Zhang, Yuelin Liu, Yinfeng Wang, Feng Lin, Alex Tuffour, Jie Gu, Guangxiang Liu, Haifeng Shi
    Environmental Chemistry Letters.2022; 20(3): 1611.     CrossRef
  • Differential fat accumulation in early adulthood according to adolescent‐BMI and heavy metal exposure
    Larissa Betanzos‐Robledo, Martha M. Téllez‐Rojo, Hector Lamadrid‐Figueroa, Ernesto Roldan‐Valadez, Karen E. Peterson, Erica C. Jansen, Nil Basu, Alejandra Cantoral
    New Directions for Child and Adolescent Development.2022; 2022(181-182): 37.     CrossRef
  • The Association of Mercury and ALT with Obesity in Korean Adults: Using Data from the Korea National Health and Nutrition Examination Survey for 11 Years (KNHANES 2005, 2008~2017)
    Sang Shin Pyo
    Korean Journal of Clinical Laboratory Science.2022; 54(3): 192.     CrossRef
  • Plasma titanium level is positively associated with metabolic syndrome: A survey in China’s heavy metal polluted regions
    Miao Huang, Jingyuan Chen, Guangyu Yan, Yiping Yang, Dan Luo, Xiang Chen, Meian He, Hong Yuan, Zhijun Huang, Yao Lu
    Ecotoxicology and Environmental Safety.2021; 208: 111435.     CrossRef
  • Relationship Between Elevated Hair Mercury Levels, Essential Element Status, and Metabolic Profile in Overweight and Obese Adults
    Anatoly V. Skalny, Jung-Su Chang, Igor P. Bobrovnitsky, Philippe Yu Kopylov, Margarita G. Skalnaya, Shih-Yi Huang, Monica Maria Bastos Paoliello, Ekaterina S. Ivanova, Weu Wang, Alexey A. Tinkov
    Biological Trace Element Research.2021; 199(8): 2874.     CrossRef
  • Associations between metabolic syndrome and four heavy metals: A systematic review and meta-analysis
    Ping Xu, Aiping Liu, Fengna Li, Alexey A. Tinkov, Longjian Liu, Ji-Chang Zhou
    Environmental Pollution.2021; 273: 116480.     CrossRef
  • Cadmium, lead and mercury in the blood of psoriatic and vitiligo patients and their possible associations with dietary habits
    Marta Wacewicz-Muczyńska, Katarzyna Socha, Jolanta Soroczyńska, Marek Niczyporuk, Maria H. Borawska
    Science of The Total Environment.2021; 757: 143967.     CrossRef
  • Crude oil and public health issues in Niger Delta, Nigeria: Much ado about the inevitable
    Orish Ebere Orisakwe
    Environmental Research.2021; 194: 110725.     CrossRef
  • Mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging
    Roger Pamphlett, Stephen Kum Jew, Philip A. Doble, David P. Bishop
    Scientific Reports.2021;[Epub]     CrossRef
  • Multiple metal exposure and obesity: A prospective cohort study of adults living along the Yangtze River, China
    Qi Zhong, Qi-rong Qin, Wan-jun Yang, Jia-liu He, Jin-liang Zhu, Zhen-yu Zhu, Fen Huang
    Environmental Pollution.2021; 285: 117150.     CrossRef
  • Association between Blood Mercury Levels and Non-Alcoholic Fatty Liver Disease in Non-Obese Populations: The Korean National Environmental Health Survey (KoNEHS) 2012–2014
    Yun-Jung Yang, Eun-Jung Yang, Kyongjin Park, Subin Oh, Taehyen Kim, Yeon-Pyo Hong
    International Journal of Environmental Research and Public Health.2021; 18(12): 6412.     CrossRef
  • Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease
    Anatoly V. Skalny, Philippe Yu Kopylov, Monica M. B. Paoliello, Jung-Su Chang, Michael Aschner, Igor P. Bobrovnitsky, Jane C.-J. Chao, Jan Aaseth, Sergei N. Chebotarev, Alexey A. Tinkov
    International Journal of Environmental Research and Public Health.2021; 18(15): 8195.     CrossRef
  • Methylmercury chronic exposure affects the expression of DNA single-strand break repair genes, induces oxidative stress, and chromosomal abnormalities in young dyslipidemic APOE knockout mice
    Cássia R. Roque, Letícia R. Sampaio, Mayumi N. Ito, Daniel V. Pinto, Juan S.R. Caminha, Paulo I.G. Nunes, Ramon S. Raposo, Flávia A. Santos, Cláudia C. Windmöller, Maria Elena Crespo-Lopez, Jacqueline I. Alvarez-Leite, Reinaldo B. Oriá, Ronald F. Pinheiro
    Toxicology.2021; 464: 152992.     CrossRef
  • Methylmercury-Induced Metabolic Alterations in Caenorhabditis elegans Are Diet-Dependent
    Nicole Crawford, Megan Martell, Tyson Nielsen, Belal Khalil, Farooq Imtiaz, Etienne Nguidjo, Jennifer Newell-Caito, Julia Bornhorst, Tanja Schwerdtle, Samuel Caito
    Toxics.2021; 9(11): 287.     CrossRef
  • Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)
    Manal Abudawood, Hajera Tabassum, Atheer H. Alanazi, Fatmah Almusallam, Feda Aljaser, Mir Naiman Ali, Naif D. Alenzi, Samyah T. Alanazi, Manal A. Alghamdi, Ghadah H. Altoum, Manar A. Alzeer, Majed O. Alotaibi, Arwa Abudawood, Hazem K. Ghneim, Lulu Abdulla
    Scientific Reports.2021;[Epub]     CrossRef
  • Association of Blood Mercury Levels with the Risks of Overweight and High Waist-to-Height Ratio in Children and Adolescents: Data from the Korean National Health and Nutrition Examination Survey
    Ky Young Cho
    Children.2021; 8(12): 1087.     CrossRef
  • The sex-specific effects of blood lead, mercury, and cadmium levels on hepatic steatosis and fibrosis: Korean nationwide cross-sectional study
    Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
    Journal of Trace Elements in Medicine and Biology.2020; 62: 126601.     CrossRef
  • Elevated blood mercury level has a non-linear association with infertility in U.S. women: Data from the NHANES 2013–2016
    Fangfang Zhu, Chi Chen, Yingxuan Zhang, Si Chen, Xian Huang, Jingwei Li, Yanxi Wang, Xiaorong Liu, Gaopi Deng, Jie Gao
    Reproductive Toxicology.2020; 91: 53.     CrossRef
  • Methylmercury Induces Metabolic Alterations in Caenorhabditis elegans: Role for C/EBP Transcription Factor
    Samuel W Caito, Jennifer Newell-Caito, Megan Martell, Nicole Crawford, Michael Aschner
    Toxicological Sciences.2020; 174(1): 112.     CrossRef
  • Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children
    Nikos Stratakis, David V. Conti, Eva Borras, Eduardo Sabido, Theano Roumeliotaki, Eleni Papadopoulou, Lydiane Agier, Xavier Basagana, Mariona Bustamante, Maribel Casas, Shohreh F. Farzan, Serena Fossati, Juan R. Gonzalez, Regina Grazuleviciene, Barbara He
    JAMA Network Open.2020; 3(3): e201007.     CrossRef
  • Elemental Analysis of Aging Human Pituitary Glands Implicates Mercury as a Contributor to the Somatopause
    Roger Pamphlett, Stephen Kum Jew, Philip A. Doble, David P. Bishop
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Mercury leads to features of polycystic ovary syndrome in rats
    Eduardo Merlo, Ingridy R.G. Schereider, Maylla R. Simões, Dalton V. Vassallo, Jones B. Graceli
    Toxicology Letters.2019; 312: 45.     CrossRef
  • In utero exposure to mercury and childhood overweight or obesity: counteracting effect of maternal folate status
    Guoying Wang, Jessica DiBari, Eric Bind, Andrew M. Steffens, Jhindan Mukherjee, Tami R. Bartell, David C. Bellinger, Xiumei Hong, Yuelong Ji, Mei-Cheng Wang, Marsha Wills-Karp, Tina L. Cheng, Xiaobin Wang
    BMC Medicine.2019;[Epub]     CrossRef
  • Mercury Is Taken Up Selectively by Cells Involved in Joint, Bone, and Connective Tissue Disorders
    Roger Pamphlett, Stephen Kum Jew
    Frontiers in Medicine.2019;[Epub]     CrossRef
  • Cohort Profile: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort in Korea
    Jee-Seon Shim, Bo Mi Song, Jung Hyun Lee, Seung Won Lee, Ji Hye Park, Dong Phil Choi, Myung Ha Lee, Kyoung Hwa Ha, Dae Jung Kim, Sungha Park, Won-Woo Lee, Yoosik Youm, Eui-Cheol Shin, Hyeon Chang Kim
    Yonsei Medical Journal.2019; 60(8): 804.     CrossRef
  • Chronic mercury at low doses impairs white adipose tissue plasticity
    Danize Aparecida Rizzetti, Patricia Corrales, Janaina Trindade Piagette, José Antonio Uranga-Ocio, Gema Medina-Gomez, Franck Maciel Peçanha, Dalton Valentim Vassallo, Marta Miguel, Giulia Alessandra Wiggers
    Toxicology.2019; 418: 41.     CrossRef
  • Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among U.S. adults in NHANES 2003–2014
    Xin Wang, Bhramar Mukherjee, Sung Kyun Park
    Environment International.2018; 121: 683.     CrossRef
  • Blood mercury concentration in relation to metabolic and weight phenotypes using the KNHANES 2011–2013 data
    Kayoung Lee
    International Archives of Occupational and Environmental Health.2018; 91(2): 185.     CrossRef
  • The association of total blood mercury levels and overweight among Korean adolescents: analysis of the Korean National Health and Nutrition Examination Survey (KNHANES) 2010–2013
    Yi-Yeon Shin, In-Kyung Ryu, Mi-Jung Park, Shin-Hye Kim
    Korean Journal of Pediatrics.2018; 61(4): 121.     CrossRef
  • Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and Model System Studies
    Antonio Planchart, Adrian Green, Cathrine Hoyo, Carolyn J. Mattingly
    Current Environmental Health Reports.2018; 5(1): 110.     CrossRef
  • Association between Blood Mercury Level and Visceral Adiposity in Adults
    Seong-Su Moon
    Diabetes & Metabolism Journal.2017; 41(2): 96.     CrossRef
The Role of Skeletal Muscle in Development of Nonalcoholic Fatty Liver Disease
Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
Diabetes Metab J. 2013;37(4):278-285.   Published online August 14, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.4.278
  • 5,620 View
  • 51 Download
  • 62 Crossref
AbstractAbstract PDFPubReader   
Background

Nonalcoholic fatty liver disease (NAFLD) is closely correlated with abnormal accumulation of visceral fat, but the role of skeletal muscle remains unclear. The aim of this study was to elucidate the role of skeletal muscle in development of NAFLD.

Methods

Among 11,116 subjects (6,242 males), we examined the effects of skeletal muscle mass and visceral fat area (VFA, by bioelectric impedance analysis) on NAFLD using by the fatty liver index (FLI).

Results

Of the total subjects (9,565 total, 5,293 males) included, 1,848 were classified as having NALFD (FLI ≥60). Body mass index, lipid profile, fasting plasma glucose, hemoglobin A1c, prevalence of type 2 diabetes (DM), hypertension (HTN), and metabolic syndrome were higher in males than females, but FLI showed no significant difference. The low FLI group showed the lowest VFA and highest skeletal muscle mass of all the groups. Skeletal muscle to visceral fat ratio (SVR) and skeletal muscle index had inverse correlations with FLI, when adjusted for age and gender. In multivariate regression analysis, SVR was negatively associated with FLI. Among SVR quartiles, the highest quartile showed very low risk of NAFLD when adjusted for age, gender, lipid profile, DM, HTN, and high sensitivity C-reactive protein from the lowest quartiles (odds ratio, 0.037; 95% confidence interval, 0.029 to 0.049).

Conclusion

Skeletal muscle mass was inversely associated with visceral fat area, and higher skeletal muscle mass may have a beneficial effect in preventing NAFLD. These results suggest that further studies are needed to ameliorate or slow the progression of sarcopenia.

Citations

Citations to this article as recorded by  
  • Development and external validation of a machine-learning based model to predict pre-sarcopenia in MASLD population: Results from NHANES 2017–2018
    Siwei Yang, Jianan Yu, Qiyang Chen, Xuedong Sun, Yuefeng Hu, Tianhao Su, Jian Li, Long Jin
    Annals of Hepatology.2025; 30(2): 101585.     CrossRef
  • Effects of nonalcoholic fatty liver disease on sarcopenia: evidence from genetic methods
    Jiaqin Yuan, Jinglin Zhang, Qiang Luo, Lipeng Peng
    Scientific Reports.2024;[Epub]     CrossRef
  • Influence of Sugar-Sweetened Beverages Intake on Sarcopenic Obesity, Visceral Obesity, and Sarcopenia in Lebanese Patients with MASLD: A Case-Control Study
    Maha Hoteit, Myriam Dagher, Nikolaos Tzenios, Najat Al Kaaki, Ghadir Rkein, Abdul Rahman Chahine, Yonna Sacre, Samer Hotayt, Rami Matar, Mahmoud Hallal, Micheal Maitar, Bilal Hotayt
    Healthcare.2024; 12(5): 591.     CrossRef
  • Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of metabolic dysfunction-associated steatotic liver disease in a Chinese population
    Chenbing Liu, Nan Li, Di Sheng, Yahong Shao, Lihong Qiu, Chao Shen, Zhong Liu
    Lipids in Health and Disease.2024;[Epub]     CrossRef
  • Sex difference in skeletal muscle mass in relation to metabolic dysfunction-associated steatotic liver disease: a propensity score matching study
    Da-Hye Son, Yu-Jin Kwon, Jun-Hyuk Lee
    The Journal of nutrition, health and aging.2024; 28(6): 100270.     CrossRef
  • Bibliometric and visualized analysis of the correlation between sarcopenia and chronic liver diseases from 2000 to 2023
    Jiaming Lan, Haozhuo Guo, Jingyu Zou, Jian Xue, Hongbo Ni, Liuchun Wang, Tianhang Ren, Sijie Chai, Haoyang Jiang, Chan Gou, Fan Wang, Shuai Wang, Xiaohe Xu, Yue Wang, Meng Niu
    Portal Hypertension & Cirrhosis.2024; 3(3): 139.     CrossRef
  • How Sarcopenia, Muscle Mass, Strength, and Performance Relate to Non-Alcoholic Fatty Liver Disease: A Systematic Review
    Joana Rigor, Matilde Monteiro-Soares, Pedro Barata, Daniela Martins-Mendes
    Sci.2024; 6(4): 59.     CrossRef
  • Using hyperhomocysteinemia and body composition to predict the risk of non-alcoholic fatty liver disease in healthcare workers
    Xiaoyan Hao, Honghai He, Liyuan Tao, Peng Wang
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Diagnostic Criteria and Prognostic Relevance of Sarcopenia in Patients with Inflammatory Bowel Disease—A Systematic Review
    Claudia-Gabriela Potcovaru, Petruța Violeta Filip, Oana-Maria Neagu, Laura Sorina Diaconu, Teodor Salmen, Delia Cinteză, Anca Pantea Stoian, Florin Bobirca, Mihai Berteanu, Corina Pop
    Journal of Clinical Medicine.2023; 12(14): 4713.     CrossRef
  • Association between Muscle Mass Deficits and Metabolic Dysfunction-Associated Fatty Liver Disease in Adults with Body Mass Index Less than 23 kg/m2
    Mi Young Lee, Hee Jeong Choi, Han Jin Oh
    Korean Journal of Family Practice.2023; 13(3): 171.     CrossRef
  • Sex influences the association between appendicular skeletal muscle mass to visceral fat area ratio and non-alcoholic steatohepatitis in patients with biopsy-proven non-alcoholic fatty liver disease
    Gang Li, Rafael S. Rios, Xin-Xin Wang, Yue Yu, Kenneth I. Zheng, Ou-Yang Huang, Liang-Jie Tang, Hong-Lei Ma, Yi Jin, Giovanni Targher, Christopher D. Byrne, Xiao-Yan Pan, Ming-Hua Zheng
    British Journal of Nutrition.2022; 127(11): 1613.     CrossRef
  • 2019 Global NAFLD Prevalence: A Systematic Review and Meta-analysis
    Michael H. Le, Yee Hui Yeo, Xiaohe Li, Jie Li, Biyao Zou, Yuankai Wu, Qing Ye, Daniel Q. Huang, Changqing Zhao, Jie Zhang, Chenxi Liu, Na Chang, Feng Xing, Shiping Yan, Zi Hui Wan, Natasha Sook Yee Tang, Maeda Mayumi, Xinting Liu, Chuanli Liu, Fajuan Rui,
    Clinical Gastroenterology and Hepatology.2022; 20(12): 2809.     CrossRef
  • Impact of Sarcopenia and Myosteatosis in Non-Cirrhotic Stages of Liver Diseases: Similarities and Differences across Aetiologies and Possible Therapeutic Strategies
    Annalisa Cespiati, Marica Meroni, Rosa Lombardi, Giovanna Oberti, Paola Dongiovanni, Anna Ludovica Fracanzani
    Biomedicines.2022; 10(1): 182.     CrossRef
  • Impact of Sarcopenia on the Severity of the Liver Damage in Patients With Non-alcoholic Fatty Liver Disease
    Vittoria Zambon Azevedo, Cristina Alina Silaghi, Thomas Maurel, Horatiu Silaghi, Vlad Ratziu, Raluca Pais
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Fatty Liver Index and Skeletal Muscle Density
    Julie A. Pasco, Sophia X. Sui, Emma C. West, Kara B. Anderson, Pamela Rufus-Membere, Monica C. Tembo, Natalie K. Hyde, Lana J. Williams, Zoe S. J. Liu, Mark A. Kotowicz
    Calcified Tissue International.2022; 110(6): 649.     CrossRef
  • Skeletal muscle mass to visceral fat area ratio as a predictor of NAFLD in lean and overweight men and women with effect modification by sex
    Yoosun Cho, Yoosoo Chang, Seungho Ryu, Hyun‐Suk Jung, Chan‐won Kim, Hyungseok Oh, Mi Kyung Kim, Won Sohn, Hocheol Shin, Sarah H. Wild, Christopher D. Byrne
    Hepatology Communications.2022; 6(9): 2238.     CrossRef
  • Association of Low Skeletal Muscle Mass with the Phenotype of Lean Non-Alcoholic Fatty Liver Disease
    Jun-Hyeon Byeon, Min-Kyu Kang, Min-Cheol Kim
    Healthcare.2022; 10(5): 850.     CrossRef
  • Muscle strength, but not body mass index, is associated with mortality in patients with non‐alcoholic fatty liver disease
    Phunchai Charatcharoenwitthaya, Khemajira Karaketklang, Wichai Aekplakorn
    Journal of Cachexia, Sarcopenia and Muscle.2022; 13(5): 2393.     CrossRef
  • Effect of progressive resistance training with weight loss compared with weight loss alone on the fatty liver index in older adults with type 2 diabetes: secondary analysis of a 12-month randomized controlled trial
    Christine L Freer, Elena S George, Sze-Yen Tan, Gavin Abbott, David W Dunstan, Robin M Daly
    BMJ Open Diabetes Research & Care.2022; 10(5): e002950.     CrossRef
  • Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeostasis
    Liyan Fan, David R. Sweet, Domenick A. Prosdocimo, Vinesh Vinayachandran, Ernest R. Chan, Rongli Zhang, Olga Ilkayeva, Yuan Lu, Komal S. Keerthy, Chloe E. Booth, Christopher B. Newgard, Mukesh K. Jain
    Journal of Clinical Investigation.2021;[Epub]     CrossRef
  • “Bioelectrical impedance analysis in managing sarcopenic obesity in NAFLD”
    David J. Hanna, Scott T. Jamieson, Christine S. Lee, Christopher A. Pluskota, Nicole J. Bressler, Peter N. Benotti, Sandeep Khurana, David D. K. Rolston, Christopher D. Still
    Obesity Science & Practice.2021; 7(5): 629.     CrossRef
  • Decreased Muscle-to-Fat Mass Ratio Is Associated with Low Muscular Fitness and High Alanine Aminotransferase in Children and Adolescent Boys in Organized Sports Clubs
    Kai Ushio, Yukio Mikami, Hiromune Obayashi, Hironori Fujishita, Kouki Fukuhara, Tetsuhiko Sakamitsu, Kazuhiko Hirata, Yasunari Ikuta, Hiroaki Kimura, Nobuo Adachi
    Journal of Clinical Medicine.2021; 10(11): 2272.     CrossRef
  • Association of Skeletal Muscle and Adipose Tissue Distribution with Histologic Severity of Non-Alcoholic Fatty Liver
    Min-Kyu Kang, Jung-Hun Baek, Young-Oh Kweon, Won-Young Tak, Se-Young Jang, Yu-Rim Lee, Keun Hur, Gyeonghwa Kim, Hye-Won Lee, Man-Hoon Han, Joon-Hyuk Choi, Soo-Young Park, Jung-Gil Park
    Diagnostics.2021; 11(6): 1061.     CrossRef
  • Association of Body Composition and Sarcopenia with NASH in Obese Patients
    Sophia Marie-Therese Schmitz, Lena Schooren, Andreas Kroh, Alexander Koch, Christine Stier, Ulf Peter Neumann, Tom Florian Ulmer, Patrick Hamid Alizai
    Journal of Clinical Medicine.2021; 10(15): 3445.     CrossRef
  • Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK/SIRT1-mediated suppression of inflammation
    Do Hyeon Pyun, Tae Jin Kim, Seung Yeon Park, Hyun Jung Lee, A.M. Abd El-Aty, Ji Hoon Jeong, Tae Woo Jung
    Molecular and Cellular Endocrinology.2021; 538: 111464.     CrossRef
  • Hepatic Steatosis Contributes to the Development of Muscle Atrophy via Inter-Organ Crosstalk
    Kenneth Pasmans, Michiel E. Adriaens, Peter Olinga, Ramon Langen, Sander S. Rensen, Frank G. Schaap, Steven W. M. Olde Damink, Florian Caiment, Luc J. C. van Loon, Ellen E. Blaak, Ruth C. R. Meex
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Muscle mass and cellular membrane integrity assessment in patients with nonalcoholic fatty liver disease
    Iasmin dos Santos Barreto, Raquel Oliveira dos Santos, Raquel Rocha, Claudineia de Souza, Naiade Almeida, Luiza Valois Vieira, Rafael Leiróz, Manoel Sarno, Carla Daltro, Helma Pinchemel Cotrim
    Revista da Associação Médica Brasileira.2021; 67(9): 1233.     CrossRef
  • A significant association of non-obese non-alcoholic fatty liver disease with sarcopenic obesity
    Kazuhiro Kashiwagi, Michiyo Takayama, Kayoko Fukuhara, Ryoko Shimizu-Hirota, Po-Sung Chu, Nobuhiro Nakamoto, Nagamu Inoue, Yasushi Iwao, Takanori Kanai
    Clinical Nutrition ESPEN.2020; 38: 86.     CrossRef
  • Improvement in Menopause‐Associated Hepatic Lipid Metabolic Disorders by Herbal Formula HPC03 on Ovariectomized Rats
    BoYoon Chang, Dae Sung Kim, SungYeon Kim, Silvia Wein
    Evidence-Based Complementary and Alternative Medicine.2020;[Epub]     CrossRef
  • Sarcopenia is associated with non-alcoholic fatty liver disease in men with type 2 diabetes
    D.H. Seo, Y.-h. Lee, S.W. Park, Y.J. Choi, B.W. Huh, E. Lee, K.B. Huh, S.H. Kim, B.-S. Cha
    Diabetes & Metabolism.2020; 46(5): 362.     CrossRef
  • Nonalcoholic fatty liver disease and sarcopenia: pathophysiological connections and therapeutic implications
    Tiziana Fernández-Mincone, Felipe Contreras-Briceño, Maximiliano Espinosa-Ramírez, Patricio García-Valdés, Antonio López-Fuenzalida, Arnoldo Riquelme, Juan Pablo Arab, Daniel Cabrera, Marco Arrese, Francisco Barrera
    Expert Review of Gastroenterology & Hepatology.2020; 14(12): 1141.     CrossRef
  • Association between Atrial Fibrillation and Advanced Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease
    Min Kyu Kang, Jung Gil Park, Min Cheol Kim
    Yonsei Medical Journal.2020; 61(10): 860.     CrossRef
  • Relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease
    Hwi Young Kim, Su Jung Baik, Hye Ah Lee, Byoung Kwon Lee, Hye Sun Lee, Tae Hun Kim, Kwon Yoo
    Scientific Reports.2020;[Epub]     CrossRef
  • Fisetin Alleviates Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice
    Myung-Sook Choi, Ji-Young Choi, Eun-Young Kwon
    Journal of Medicinal Food.2020; 23(10): 1019.     CrossRef
  • Relationship between relative skeletal muscle mass and nonalcoholic fatty liver disease: a systematic review and meta-analysis
    Changzhou Cai, Xin Song, Yishu Chen, Xueyang Chen, Chaohui Yu
    Hepatology International.2020; 14(1): 115.     CrossRef
  • Sarcopenia Is a New Risk Factor of Nonalcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Disease
    Min Kyu Kang, Kyeong Ok Kim, Min Cheol Kim, Jung Gil Park, Byung Ik Jang
    Digestive Diseases.2020; 38(6): 507.     CrossRef
  • Relationship between Muscle Mass/Strength and Hepatic Fat Content in Post-Menopausal Women
    Yajie Zhang, Dajiang Lu, Renwei Wang, Weijie Fu, Shengnian Zhang
    Medicina.2019; 55(10): 629.     CrossRef
  • Lower hand grip strength in older adults with non-alcoholic fatty liver disease: a nationwide population-based study
    Beom-Jun Kim, Seong Hee Ahn, Seung Hun Lee, Seongbin Hong, Mark W. Hamrick, Carlos M. Isales, Jung-Min Koh
    Aging.2019; 11(13): 4547.     CrossRef
  • Nonalcoholic Fatty Liver Disease in Nonobese Subjects of African Origin Has Atypical Metabolic Characteristics
    Debbie S Thompson, Ingrid A Tennant, Deanne P Soares, Clive Osmond, Chris D Byrne, Terrence E Forrester, Michael S Boyne
    Journal of the Endocrine Society.2019; 3(11): 2051.     CrossRef
  • Sarcopenia in patients with non‐alcoholic fatty liver disease: is it a clinically significant entity?
    C. H. De Fré, M. A. De Fré, W. J. Kwanten, B. J. Op de Beeck, L. F. Van Gaal, S. M. Francque
    Obesity Reviews.2019; 20(2): 353.     CrossRef
  • Nonalcoholic Fatty Liver Disease in The Rotterdam Study: About Muscle Mass, Sarcopenia, Fat Mass, and Fat Distribution
    Louise Johanna Maria Alferink, Katerina Trajanoska, Nicole Stephanie Erler, Josje Dorothea Schoufour, Robert Jacobus de Knegt, M. Arfan Ikram, Harry Leonardus Antonius Janssen, Oscar H. Franco, Herold J. Metselaar, Fernando Rivadeneira, Sarwa Darwish Mura
    Journal of Bone and Mineral Research.2019; 34(7): 1254.     CrossRef
  • Sarcopenia Is Significantly Associated with Presence and Severity of Nonalcoholic Fatty Liver Disease
    Goh Eun Chung, Min Joo Kim, Jeong Yoon Yim, Joo Sung Kim, Ji Won Yoon
    Journal of Obesity & Metabolic Syndrome.2019; 28(2): 129.     CrossRef
  • Association of low skeletal muscle mass with advanced liver fibrosis in patients with non‐alcoholic fatty liver disease
    Min Kyu Kang, Jung Gil Park, Heon Ju Lee, Min Cheol Kim
    Journal of Gastroenterology and Hepatology.2019; 34(9): 1633.     CrossRef
  • Whole‐body vibration for patients with nonalcoholic fatty liver disease: a 6‐month prospective study
    Sechang Oh, Natsumi Oshida, Noriko Someya, Tsuyoshi Maruyama, Tomonori Isobe, Yoshikazu Okamoto, Taeho Kim, Bokun Kim, Junichi Shoda
    Physiological Reports.2019; 7(9): e14062.     CrossRef
  • L-Lysine Attenuates Hepatic Steatosis in Senescence-Accelerated Mouse Prone 8 Mice
    Tomonori SATO, Nao MURAMATSU, Yoshiaki ITO, Yoshio YAMAMOTO, Takashi NAGASAWA
    Journal of Nutritional Science and Vitaminology.2018; 64(3): 192.     CrossRef
  • Short-term treatment with metformin reduces hepatic lipid accumulation but induces liver inflammation in obese mice
    Alexandre Abilio de Souza Teixeira, Camila O. Souza, Luana A. Biondo, Loreana Sanches Silveira, Edson A. Lima, Helena A. Batatinha, Adriane Pereira Araujo, Michele Joana Alves, Sandro Massao Hirabara, Rui Curi, José Cesar Rosa Neto
    Inflammopharmacology.2018; 26(4): 1103.     CrossRef
  • Vitamin D and Related Deficiencies, Sarcopenia and Visceral Obesity in Obese People with NAFLD
    Mihaela Petrova
    Gastroenterology & Hepatology: Open Access.2018;[Epub]     CrossRef
  • Grip Strength Moderates the Association between Anthropometric and Body Composition Indicators and Liver Fat in Youth with an Excess of Adiposity
    Robinson Ramírez-Vélez, Mikel Izquierdo, Jorge Correa-Bautista, Alejandra Tordecilla-Sanders, María Correa-Rodríguez, Jacqueline Schmidt Rio-Valle, Emilio González-Jiménez, Katherine González-Ruíz
    Journal of Clinical Medicine.2018; 7(10): 347.     CrossRef
  • Longitudinal Changes in Muscle Mass and Strength, and Bone Mass in Older Adults: Gender-Specific Associations Between Muscle and Bone Losses
    Kyoung Min Kim, Soo Lim, Tae Jung Oh, Jae Hoon Moon, Sung Hee Choi, Jae Young Lim, Ki Woong Kim, Kyong Soo Park, Hak Chul Jang
    The Journals of Gerontology: Series A.2018; 73(8): 1062.     CrossRef
  • Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle
    Eleonora Poggiogalle, Lorenzo Maria Donini, Andrea Lenzi, Claudio Chiesa, Lucia Pacifico
    World Journal of Gastroenterology.2017; 23(10): 1747.     CrossRef
  • Sarcopenia and non-alcoholic fatty liver disease: Is there a relationship? A systematic review
    Cristiane V Tovo, Sabrina A Fernandes, Caroline Buss, Angelo A de Mattos
    World Journal of Hepatology.2017; 9(6): 326.     CrossRef
  • Multiple molecular targets in the liver, adipose tissue and skeletal muscle in ginger-elicited amelioration of nonalcoholic fatty liver disease
    Chunxia Wang, Robert Batey, Johji Yamahara, Yuhao Li
    Journal of Functional Foods.2017; 36: 43.     CrossRef
  • Importance of Lean Muscle Maintenance to Improve Insulin Resistance by Body Weight Reduction in Female Patients with Obesity
    Yaeko Fukushima, Satoshi Kurose, Hiromi Shinno, Ha Cao Thu, Nana Takao, Hiromi Tsutsumi, Yutaka Kimura
    Diabetes & Metabolism Journal.2016; 40(2): 147.     CrossRef
  • Fatty Liver Index Associates with Relative Sarcopenia and GH/ IGF- 1 Status in Obese Subjects
    Eleonora Poggiogalle, Carla Lubrano, Lucio Gnessi, Stefania Mariani, Andrea Lenzi, Lorenzo Maria Donini, Rasheed Ahmad
    PLOS ONE.2016; 11(1): e0145811.     CrossRef
  • The relationship between hepatic steatosis and skeletal muscle mass index in men with type 2 diabetes
    Yoshitaka Hashimoto, Takafumi Osaka, Takuya Fukuda, Muhei Tanaka, Masahiro Yamazaki, Michiaki Fukui
    Endocrine Journal.2016; 63(10): 877.     CrossRef
  • Sarcopenia and the cardiometabolic syndrome: A narrative review
    G. Bahat, B. İlhan
    European Geriatric Medicine.2016; 7(3): 220.     CrossRef
  • Low skeletal muscle mass is associated with non-alcoholic fatty liver disease in Korean adults: the Fifth Korea National Health and Nutrition Examination Survey
    Hee Yeon Kim, Chang Wook Kim, Chung-Hwa Park, Jong Young Choi, Kyungdo Han, Anwar T Merchant, Yong-Moon Park
    Hepatobiliary & Pancreatic Diseases International.2016; 15(1): 39.     CrossRef
  • Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications
    Sven M. Francque, Denise van der Graaff, Wilhelmus J. Kwanten
    Journal of Hepatology.2016; 65(2): 425.     CrossRef
  • Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia
    Kyoung Min Kim, Hak Chul Jang, Soo Lim
    The Korean Journal of Internal Medicine.2016; 31(4): 643.     CrossRef
  • Relationship between grip strength and newly diagnosed nonalcoholic fatty liver disease in a large-scale adult population
    Ge Meng, Hongmei Wu, Liyun Fang, Chunlei Li, Fei Yu, Qing Zhang, Li Liu, Huanmin Du, Hongbin Shi, Yang Xia, Xiaoyan Guo, Xing Liu, Xue Bao, Qian Su, Yeqing Gu, Huijun Yang, Bin Yu, Yuntang Wu, Zhong Sun, Kaijun Niu
    Scientific Reports.2016;[Epub]     CrossRef
  • Volume-dependent effect of supervised exercise training on fatty liver and visceral adiposity index in subjects with type 2 diabetes The Italian Diabetes Exercise Study (IDES)
    Stefano Balducci, Patrizia Cardelli, Luca Pugliese, Valeria D’Errico, Jonida Haxhi, Elena Alessi, Carla Iacobini, Stefano Menini, Lucilla Bollanti, Francesco G. Conti, Antonio Nicolucci, Giuseppe Pugliese
    Diabetes Research and Clinical Practice.2015; 109(2): 355.     CrossRef
  • Sarcopenia is a risk factor for elevated aminotransferase in men independently of body mass index, dietary habits, and physical activity
    Ki Deok Yoo, Dae Won Jun, Kang Nyeong Lee, Hang Lak Lee, Oh Young Lee, Byung Chul Yoon, Ho Soon Choi
    Digestive and Liver Disease.2015; 47(4): 303.     CrossRef
Influence of Visceral Adiposity on Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes Mellitus
Eun-Hee Jang, Na-Young Kim, Yong-Moon Park, Mee-Kyoung Kim, Ki Hyun Baek, Ki-Ho Song, Kwang Woo Lee, Hyuk-Sang Kwon
Diabetes Metab J. 2012;36(4):285-292.   Published online August 20, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.4.285
  • 4,256 View
  • 39 Download
  • 5 Crossref
AbstractAbstract PDFPubReader   
Background

The aim of this study was to investigate the influences of visceral adiposity on cardiovascular autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus.

Methods

Two hundred eleven patients with type 2 diabetes participated in this study. Anthropometric and metabolic parameters were measured, and the visceral fat area was assessed using computed tomography. CAN was diagnosed using a cardiovascular reflex test. We analyzed the correlation between the visceral fat area and each parameter in this test.

Results

The mean age, body mass index (BMI), and duration of diabetes of the study population were 60±14 years (mean±standard deviation), 25.1±4.2 kg/m2, and 12.3±8.9 years, respectively. The visceral fat area showed positive correlations with age, BMI, waist circumference, and subcutaneous fat area. There was no statistically significant difference in the cardiovascular reflex test outcome between genders. Univariate linear regression analysis showed that an increased visceral fat area diminished good heart rate response to a Valsalva maneuver (R2=4.9%, P=0.013 in an unadjusted model), but only in women. This statistical association was preserved after adjusting for age and BMI (R2=9.8%, P=0.0072).

Conclusion

The results of this study suggest that visceral adiposity contributes to an autonomic imbalance to some degree, as demonstrated by the impaired cardiovascular reflex test among women with type 2 diabetes.

Citations

Citations to this article as recorded by  
  • Excessive generalized and visceral adiposity is associated with a higher prevalence of diabetic retinopathy in Caucasian patients with type 2 diabetes
    Andrea Tumminia, Agostino Milluzzo, Nunzia Carrubba, Federica Vinciguerra, Roberto Baratta, Lucia Frittitta
    Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(3): 763.     CrossRef
  • Obesity, Metabolic Syndrome and the Risk of Microvascular Complications in Patients with Diabetes mellitus
    Niki Katsiki, Panagiotis Anagnostis, Kalliopi Kotsa, Dimitrios G. Goulis, Dimitri P. Mikhailidis
    Current Pharmaceutical Design.2019; 25(18): 2051.     CrossRef
  • Morphologic Comparison of Peripheral Nerves in Adipocyte Tissue from db/db Diabetic versus Normal Mice
    Kyung Ae Lee, Na Young Lee, Tae Sun Park, Heung Yong Jin
    Diabetes & Metabolism Journal.2018; 42(2): 169.     CrossRef
  • Gender differences in the perception of difficulty of self-management in patients with diabetes mellitus: a mixed-methods approach
    Hideyo Tsutsui, Kyoko Nomura, Masataka Kusunoki, Tetsuya Ishiguro, Takayoshi Ohkubo, Yoshiharu Oshida
    Diabetology International.2016; 7(3): 289.     CrossRef
  • Contribution of subcutaneous abdominal fat on ultrasonography to carotid atherosclerosis in patients with type 2 diabetes mellitus
    Chan-Hee Jung, Bo-Yeon Kim, Kyu-Jin Kim, Sang-Hee Jung, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
    Cardiovascular Diabetology.2014;[Epub]     CrossRef
ATP-Sensitive Potassium Channel-Deficient Mice Show Hyperphagia but Are Resistant to Obesity
Yeul Bum Park, Yun Jung Choi, So Young Park, Jong Yeon Kim, Seong Ho Kim, Dae Kyu Song, Kyu Chang Won, Yong Woon Kim
Diabetes Metab J. 2011;35(3):219-225.   Published online June 30, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.3.219
  • 4,146 View
  • 35 Download
  • 14 Crossref
AbstractAbstract PDFPubReader   
Background

The hypothalamus, the center for body weight regulation, can sense changes in blood glucose level based on ATP-sensitive potassium (KATP) channels in the hypothalamic neurons. We hypothesized that a lack of glucose sensing in the hypothalamus affects the regulations of appetite and body weight.

Methods

To evaluate this hypothesis, the responses to glucose loading and high fat feeding for eight weeks were compared in Kir6.2 knock-out (KO) mice and control C57BL/6 mice, because Kir6.2 is a key component of the KATP channel.

Results

The hypothalamic neuropeptide Y (NPY) analyzed one hour after glucose injection was suppressed in C57BL/6 mice, but not in Kir6.2 KO mice, suggesting a blunted hypothalamic response to glucose in Kir6.2 KO mice. The hypothalamic NPY expression at a fed state was elevated in Kir6.2 KO mice and was accompanied with hyperphagia. However, the retroperitoneal fat mass was markedly decreased in Kir6.2 KO mice compared to that in C57BL/6 mice. Moreover, the body weight and visceral fat following eight weeks of high fat feeding in Kir6.2 KO mice were not significantly different from those in control diet-fed Kir6.2 KO mice, while body weight and visceral fat mass were elevated due to high fat feeding in C57BL/6 mice.

Conclusion

These results suggested that Kir6.2 KO mice showed a blunted hypothalamic response to glucose loading and elevated hypothalamic NPY expression accompanied with hyperphagia, while visceral fat mass was decreased, suggesting resistance to diet-induced obesity. Further study is needed to explain this phenomenon.

Citations

Citations to this article as recorded by  
  • 17β-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERα signaling
    Kaifan Yu, Yanlin He, Ilirjana Hyseni, Zhou Pei, Yongjie Yang, Pingwen Xu, Xing Cai, Hesong Liu, Na Qu, Hailan Liu, Yang He, Meng Yu, Chen Liang, Tingting Yang, Julia Wang, Pierre Gourdy, Jean-Francois Arnal, Francoise Lenfant, Yong Xu, Chunmei Wang
    Molecular Metabolism.2020; 42: 101053.     CrossRef
  • Brain Glucose-Sensing Mechanism and Energy Homeostasis
    A. J. López-Gambero, F. Martínez, K. Salazar, M. Cifuentes, F. Nualart
    Molecular Neurobiology.2019; 56(2): 769.     CrossRef
  • The involvement of purinergic signalling in obesity
    Geoffrey Burnstock, Daniela Gentile
    Purinergic Signalling.2018; 14(2): 97.     CrossRef
  • High‐fat‐diet‐induced remission of diabetes in a subset of KATP‐GOF insulin‐secretory‐deficient mice
    Zihan Yan, Zeenat A. Shyr, Manuela Fortunato, Alecia Welscher, Mariana Alisio, Michael Martino, Brian N. Finck, Hannah Conway, Maria S. Remedi
    Diabetes, Obesity and Metabolism.2018; 20(11): 2574.     CrossRef
  • Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis
    Yue Ma, Risheka Ratnasabapathy, Chioma Izzi‐Engbeaya, Marie‐Sophie Nguyen‐Tu, Errol Richardson, Sufyan Hussain, Ivan De Backer, Christopher Holton, Mariana Norton, Gaelle Carrat, Blanche Schwappach, Guy A. Rutter, Waljit S. Dhillo, James Gardiner
    Diabetes, Obesity and Metabolism.2018; 20(9): 2246.     CrossRef
  • Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2
    Woo Young Chung, Jung Woo Han, Woon Heo, Min Goo Lee, Joo Young Kim
    Molecular and Cellular Biochemistry.2018; 447(1-2): 165.     CrossRef
  • Insights into the role of neuronal glucokinase
    Ivan De Backer, Sufyan S. Hussain, Stephen R. Bloom, James V. Gardiner
    American Journal of Physiology-Endocrinology and Metabolism.2016; 311(1): E42.     CrossRef
  • Obesogenic and Diabetogenic Effects of High-Calorie Nutrition Require Adipocyte BK Channels
    Julia Illison, Lijun Tian, Heather McClafferty, Martin Werno, Luke H. Chamberlain, Veronika Leiss, Antonia Sassmann, Stefan Offermanns, Peter Ruth, Michael J. Shipston, Robert Lukowski
    Diabetes.2016; 65(12): 3621.     CrossRef
  • ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes
    Leslie J. Baier, Yunhua Li Muller, Maria Sara Remedi, Michael Traurig, Paolo Piaggi, Gregory Wiessner, Ke Huang, Alyssa Stacy, Sayuko Kobes, Jonathan Krakoff, Peter H. Bennett, Robert G. Nelson, William C. Knowler, Robert L. Hanson, Colin G. Nichols, Clif
    Diabetes.2015; 64(12): 4322.     CrossRef
  • Glucokinase activity in the arcuate nucleus regulates glucose intake
    Syed Hussain, Errol Richardson, Yue Ma, Christopher Holton, Ivan De Backer, Niki Buckley, Waljit Dhillo, Gavin Bewick, Shuai Zhang, David Carling, Steve Bloom, James Gardiner
    Journal of Clinical Investigation.2015; 125(1): 337.     CrossRef
  • Dissecting the Etiology of Type 2 Diabetes in the Pima Indian Population
    Ewan R. Pearson
    Diabetes.2015; 64(12): 3993.     CrossRef
  • Ocular Hypotensive Effects of the ATP-Sensitive Potassium Channel Opener Cromakalim in Human and Murine Experimental Model Systems
    Uttio Roy Chowdhury, Cindy K. Bahler, Bradley H. Holman, Peter I. Dosa, Michael P. Fautsch, Ted S Acott
    PLOS ONE.2015; 10(11): e0141783.     CrossRef
  • Differential gene expression pattern in hypothalamus of chickens during fasting-induced metabolic reprogramming: Functions of glucose and lipid metabolism in the feed intake of chickens
    Xin-Ling Fang, Xiao-Tong Zhu, Sheng-Feng Chen, Zhi-Qi Zhang, Qing-Jie Zeng, Lin Deng, Jian-Long Peng, Jian-Jian Yu, Li-Na Wang, Song-Bo Wang, Ping Gao, Qing-Yan Jiang, Gang Shu
    Poultry Science.2014; 93(11): 2841.     CrossRef
  • Combined Treatment of Betulinic Acid, a PTP1B Inhibitor, with Orthosiphon stamineus Extract Decreases Body Weight in High-Fat–Fed Mice
    Yoon-Jung Choi, So-Young Park, Jong-Yeon Kim, Kyu-Chang Won, Bo-Ra Kim, Jong-Keun Son, Seung-Ho Lee, Yong-Woon Kim
    Journal of Medicinal Food.2013; 16(1): 2.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP