KDA
- Current
- Browse
- Collections
-
For contributors
- For Authors
- Instructions for authors
- Article processing charge
- For Reviewers
- Instructions for reviewers
- How to become a reviewer
- Best reviewers
- For Readers
- Readership
- Subscription
- Permission guidelines
- About
- Editorial policy
Search
- Page Path
- HOME > Search
Original Article
- Metabolic Risk/Epidemiology
- Synergistic Interaction between Hyperuricemia and Abdominal Obesity as a Risk Factor for Metabolic Syndrome Components in Korean Population
- Min Jin Lee, Ah Reum Khang, Yang Ho Kang, Mi Sook Yun, Dongwon Yi
- Diabetes Metab J. 2022;46(5):756-766. Published online January 20, 2022
- DOI: https://doi.org/10.4093/dmj.2021.0166
- 6,397 View
- 277 Download
- 8 Web of Science
- 9 Crossref
-
Abstract
PDF
Supplementary Material
PubReader 
ePub - Background
The present study investigated the role of synergistic interaction between hyperuricemia and abdominal obesity as a risk factor for the components of metabolic syndrome.
Methods
We performed a cross-sectional study using the data of 16,094 individuals from the seventh Korean National Health and Nutrition Examination Survey (2016 to 2018). The adjusted odds ratios of metabolic syndrome and its components were analyzed by multivariate logistic regression analysis. The presence of synergistic interaction between hyperuricemia and abdominal obesity was evaluated by calculating the additive scales—the relative excess risk due to interaction, attributable proportion due to interaction, and synergy index (SI).
Results
There was a synergistic interaction between hyperuricemia and abdominal obesity in hypertriglyceridemia (men: SI, 1.39; 95% confidence interval [CI], 1.01 to 1.98; women: SI, 1.61; 95% CI, 1.02 to 2.69), and low high-density lipoprotein cholesterol (HDL-C) (men: SI, 2.03; 95% CI, 1.41 to 2.91; women: SI, 1.70; 95% CI, 1.05 to 2.95). There was no significant synergistic interaction between hyperuricemia and abdominal obesity for the risk of high blood pressure (men: SI, 1.22; 95% CI, 0.85 to 1.77; women: SI, 1.53; 95% CI, 0.79 to 2.97), and hyperglycemia (men: SI, 1.03; 95% CI, 0.72 to 1.47; women: SI, 1.39; 95% CI, 0.75 to 2.57).
Conclusion
Hyperuricemia and abdominal obesity synergistically increased the risk of hypertriglyceridemia and low HDL-C in both sexes. -
Citations
Citations to this article as recorded by
- Prevalence and factors associated with overweight, obesity and central obesity among adults in Shenmu City, Shaanxi Province, China
Mingxia Liu, Chunjiao Jia, Yaoda Hu, Juan Liu, Lizhen Liu, Shengli Sun, Haiying Wang, Yonglin Liu
Preventive Medicine Reports.2024; 40: 102673. CrossRef - Synergistic interaction between hyperlipidemia and obesity as a risk factor for stress urinary incontinence in Americans
Fangyi Zhu, Mao Chen, Ya Xiao, Xiaoyu Huang, Liying Chen, Li Hong
Scientific Reports.2024;[Epub] CrossRef - Uric Acid Inhibits Mice Pancreatic Steatosis via the Glycerophospholipid Pathway
Yang Xiao, Lina Han, Han Wang, Helin Ke, Shaodan Xu, Zhibin Huang, Guorong Lyu, Shilin Li
ACS Omega.2024; 9(20): 21829. CrossRef - Association of resistome abundance with hyperuricaemia in elderly individuals: a metagenomics study
Zhiyang Liu, Yingbo Shen, Yulin Fu, Da Sun, Liang Li, Ziquan Lv
Frontiers in Microbiomes.2024;[Epub] CrossRef - Exploring the Relationship Between Different Obesity Metabolism Indices and Hyperuricemia in Patients with Hypertension and Coronary Heart Disease
Yuanyuan Li, Shanting Yi, Wencai Jiang, Meihui Gong
Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 3817. CrossRef - The role of cognitive function in the relationship between surrogate markers of visceral fat and depressive symptoms in general middle-aged and elderly population: A nationwide population-based study
Na Zhang, Jianqian Chao, Xueyu Wu, Hongling Chen, Min Bao
Journal of Affective Disorders.2023; 338: 581. CrossRef - Biodegradation of Uric Acid by Bacillus paramycoides-YC02
Xiaoyu Cao, Jingyuan Cai, Yu Zhang, Chao Liu, Meijie Song, Qianqian Xu, Yang Liu, Hai Yan
Microorganisms.2023; 11(8): 1989. CrossRef - A predictive model for hyperuricemia among type 2 diabetes mellitus patients in Urumqi, China
Palizhati Abudureyimu, Yuesheng Pang, Lirun Huang, Qianqian Luo, Xiaozheng Zhang, Yifan Xu, Liang Jiang, Patamu Mohemaiti
BMC Public Health.2023;[Epub] CrossRef - Dietary Ferulic Acid Ameliorates Metabolism Syndrome-Associated Hyperuricemia in Rats via Regulating Uric Acid Synthesis, Glycolipid Metabolism, and Hepatic Injury
Nanhai Zhang, Jingxuan Zhou, Lei Zhao, Ou Wang, Liebing Zhang, Feng Zhou
Frontiers in Nutrition.2022;[Epub] CrossRef
- Prevalence and factors associated with overweight, obesity and central obesity among adults in Shenmu City, Shaanxi Province, China
First
Prev
