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1 "Hyperandrogenism"
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Original Article
FTO Gene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean Women
Do Kyeong Song, Hyejin Lee, Jee-Young Oh, Young Sun Hong, Yeon-Ah Sung
Diabetes Metab J. 2014;38(4):302-310.   Published online August 20, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.4.302
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  • 26 Web of Science
  • 25 Crossref
AbstractAbstract PDFPubReader   
Background

The fat mass and obesity-associated (FTO) gene is associated with obesity and type 2 diabetes mellitus. Obesity and insulin resistance are also common features of polycystic ovary syndrome (PCOS). Therefore, the FTO gene might be a candidate gene for PCOS susceptibility. The aim of the present study was to evaluate the effects of FTO gene variants on PCOS susceptibility and metabolic and reproductive hormonal parameters.

Methods

We recruited 432 women with PCOS (24±5 years) and 927 healthy women with regular menstrual cycles (27±5 years) and performed a case-control association study. We genotyped the single nucleotide polymorphisms rs1421085, rs17817449, and rs8050136 in the FTO gene and collected metabolic and hormonal measurements.

Results

Logistic regression revealed that the G/G genotype (rs1421085, 1.6%), the C/C genotype (rs17817449, 1.6%), and the A/A genotype (rs8050136, 1.6%) were strongly associated with an increased risk of PCOS (odds ratio, 2.551 to 2.559; all P<0.05). The strengths of these associations were attenuated after adjusting for age and BMI. The women with these genotypes were more obese and exhibited higher free androgen indices (P<0.05) and higher free testosterone levels (P=0.053 to 0.063) compared to the other genotypes. However the significant differences disappeared after adjusting for body mass index (BMI). When we analyzed the women with PCOS and the control groups separately, there were no significant differences in the metabolic and reproductive hormonal parameters according to the FTO gene variants.

Conclusion

The rs1421085, rs17817449, and rs8050136 variants of the FTO gene were associated with PCOS susceptibility and hyperandrogenemia in young Korean women. These associations may be mediated through an effect of BMI.

Citations

Citations to this article as recorded by  
  • Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome—An Update
    Imadeldin Elfaki, Rashid Mir, Mohamed E. Elnageeb, Abdullah Hamadi, Zeyad M. Alharbi, Ruqaiah I. Bedaiwi, Jamsheed Javid, Tariq Alrasheed, Dalal Alatawi, Basmah M. Alrohaf, Mohammed K. Abunab, Turki Ahmed Muqri
    Medicina.2025; 61(1): 83.     CrossRef
  • Free-androgen Index in Women with Polycystic Ovarian Syndrome: A Meta-Analysis
    Prakash Patil, Neevan D'Souza, Sudeep D. Ghate, Lakshmi Nagendra, Harish B. Girijashankar
    Journal of Health and Allied Sciences NU.2023; 13(03): 380.     CrossRef
  • Differential Association of FTO Gene variants and Haplotypes with the Susceptibility to Polycystic Ovary Syndrome According To Obesity in Women with PCOS
    Wassim Y. Almawi, Rita Nemr, Tomiris Atazhanova, Zainab H. Malalla, Sameh Sarray, Fekria E. Mustafa, Naeema A. Mahmood
    Reproductive Sciences.2023; 30(7): 2166.     CrossRef
  • FTO: a critical role in obesity and obesity-related diseases
    Dan Yin, Yiyang Li, Xingyue Liao, Dewei Tian, Yunsi Xu, Cuilan Zhou, Jun Liu, Suyun Li, Jing Zhou, Yulin Nie, Hongqing Liao, Cuiying Peng
    British Journal of Nutrition.2023; 130(10): 1657.     CrossRef
  • Association of FTO gene variant rs9939609 with polycystic ovary syndrome from Gujarat, India
    Hiral Chaudhary, Jalpa Patel, Nayan K. Jain, Sonal Panchal, Naresh Laddha, Rushikesh Joshi
    BMC Medical Genomics.2023;[Epub]     CrossRef
  • ASSOCIATION BETWEEN FAT MASS AND OBESITY ASSOCIATED (FTO) RS17817449 GENE POLYMORPHISM WITH INSULIN RESISTANCE AND OBESITY IN THE PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
    Mahbobeh Moayeri, Masoumeh Nezhadali, Mahnaz Mohamadi
    Studies in Medical Sciences.2023; 33(12): 868.     CrossRef
  • Association of FTO gene variants rs9939609 and rs1421085 with polycystic ovary syndrome
    Alaa A. Alnafjan, Afrah F. Alkhuriji, Hussah M. Alobaid, Zainb A. Babay, Mahmoud I. Khalil
    Egyptian Journal of Medical Human Genetics.2022;[Epub]     CrossRef
  • Association of FTO gene variant rs9939609 with hyperandrogenemia and fasting glucose levels in South Indian women with polycystic ovarian syndrome
    Zeinab Naghshband, Suttur S. Malini
    Egyptian Journal of Medical Human Genetics.2022;[Epub]     CrossRef
  • Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome
    Giorgia Scarfò, Simona Daniele, Jonathan Fusi, Marco Gesi, Claudia Martini, Ferdinando Franzoni, Vito Cela, Paolo Giovanni Artini
    Biomedicines.2022; 10(6): 1305.     CrossRef
  • Fat mass and Obesity Associated (FTO) gene and polycystic ovary syndrome: Insight into pathogenesis and association with insulin resistance
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    Human Nutrition & Metabolism.2022; 30: 200174.     CrossRef
  • Effect of green cardamom on the expression of genes implicated in obesity and diabetes among obese women with polycystic ovary syndrome: a double blind randomized controlled trial
    Sahar Cheshmeh, Negin Elahi, Maysa Ghayyem, Elaheh Mosaieby, Shima Moradi, Yahya Pasdar, Susan Tahmasebi, Mehdi Moradinazar
    Genes & Nutrition.2022;[Epub]     CrossRef
  • In depth analysis of the association of FTO SNP (rs9939609) with the expression of classical phenotype of PCOS: a Sri Lankan study
    Umayal Branavan, Sulochana Wijesundera, Vishvanath Chandrasekaran, Carukshi Arambepola, Chandrika Wijeyaratne
    BMC Medical Genetics.2020;[Epub]     CrossRef
  • Body Mass Index and Polycystic Ovary Syndrome: A 2-Sample Bidirectional Mendelian Randomization Study
    Yalin Zhao, Yuping Xu, Xiaomeng Wang, Lin Xu, Jianhua Chen, Chengwen Gao, Chuanhong Wu, Dun Pan, Qian Zhang, Juan Zhou, Ruirui Chen, Zhuo Wang, Han Zhao, Li You, Yunxia Cao, Zhiqiang Li, Yongyong Shi
    The Journal of Clinical Endocrinology & Metabolism.2020; 105(6): 1778.     CrossRef
  • Polikistik Over Sendromu ve Obezite: FTO ve MC4R Gen Polimorfizmlerinin Rolü
    Ayçıl ÖZTURAN ŞİRİN, Yasemin AKDEVELİOĞLU
    Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi.2020; 4(3): 275.     CrossRef
  • Vitamin D receptor and binding protein polymorphisms in women with polycystic ovary syndrome: a case control study
    Do Kyeong Song, Hyejin Lee, Young Sun Hong, Yeon-Ah Sung
    BMC Endocrine Disorders.2019;[Epub]     CrossRef
  • Phenotype and genotype of polycystic ovary syndrome in Asia: Ethnic differences
    Jin Ju Kim, Young Min Choi
    Journal of Obstetrics and Gynaecology Research.2019; 45(12): 2330.     CrossRef
  • Sex hormone binding globulin - an important biomarker for predicting PCOS risk: A systematic review and meta-analysis
    Ritu Deswal, Arun Yadav, Amita Suneja Dang
    Systems Biology in Reproductive Medicine.2018; 64(1): 12.     CrossRef
  • Association between FTO gene polymorphisms and type 2 diabetes mellitus, serum levels of apelin and androgen hormones among Iranian obese women
    Farzaneh Ghafarian-Alipour, Shayan Ziaee, Mohamad Reza Ashoori, Mir Saeid Zakeri, Mohammad Ali Boroumand, Naser Aghamohammadzadeh, Maryam Abbasi-Majdi, Fatemeh Shool, Navid Sarakhs Asbaghi, Abolghasem Mohammadi, Nosratollah Zarghami
    Gene.2018; 641: 361.     CrossRef
  • The role of FTO variants in the susceptibility of polycystic ovary syndrome and in vitro fertilization outcomes in Chinese women
    Ai Ling Liu, Hong Qing Liao, Jing Zhou, Yu Lin Nie, Cui Lan Zhou, Zhi Liang Li, Zi Fen Guo, Dong Xiu He, Yun Hua Zhu, Cui Ying Peng
    Gynecological Endocrinology.2018; 34(8): 719.     CrossRef
  • Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
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    PLOS ONE.2017; 12(4): e0176277.     CrossRef
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  • The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome
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  • Haplotyping strategy highlights the specificity of FTO gene association with polycystic ovary syndrome in Tunisian women population
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    Gene.2015; 565(2): 166.     CrossRef
  • FTO gene variants are not associated with polycystic ovary syndrome in women from Southern Brazil
    Ramon B. Ramos, Poli Mara Spritzer
    Gene.2015; 560(1): 25.     CrossRef
  • Interaction between common variants of FTO and MC4R is associated with risk of PCOS
    Huiqin Yuan, Guoping Zhu, Fang Wang, Xiang Wang, Huihui Guo, Mo Shen
    Reproductive Biology and Endocrinology.2015;[Epub]     CrossRef

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