Citations

Citations to this article as recorded by  

• Association between METS-IR and heart failure: a cross-sectional study
  Xiaozhou Su, Chunli Zhao, Xianwei Zhang
  Frontiers in Endocrinology.2024;[Epub]     CrossRef
• Insulin–Heart Axis: Bridging Physiology to Insulin Resistance
  Alfredo Caturano, Raffaele Galiero, Erica Vetrano, Celestino Sardu, Luca Rinaldi, Vincenzo Russo, Marcellino Monda, Raffaele Marfella, Ferdinando Carlo Sasso
  International Journal of Molecular Sciences.2024; 25(15): 8369.     CrossRef
• The web of intrigue: unraveling the role of NETosis within the gut-microbiome-immune-heart axis in acute myocardial infarction and heart failure
  Tai Yasuda, Kate Deans, Aditi Shankar, Robert Chilton
  Cardiovascular Endocrinology & Metabolism.2024;[Epub]     CrossRef
• Relationship between the Mediterranean Diet and Vascular Function in Subjects with and without Increased Insulin Resistance
  Marta Gómez-Sánchez, Leticia Gómez-Sánchez, Rocío Llamas-Ramos, Emiliano Rodríguez-Sánchez, Luis García-Ortiz, Ruth Martí-Lluch, María Cortés Rodríguez, Inés Llamas-Ramos, Manuel A. Gómez-Marcos
  Nutrients.2024; 16(18): 3106.     CrossRef

Citations

Citations to this article as recorded by  

• Altered Metabolic Phenotypes and Hypothalamic Neuronal Activity Triggered by Sodium-Glucose Cotransporter 2 Inhibition (Diabetes Metab J 2023;47:784-95)
  Jae Hyun Bae
  Diabetes & Metabolism Journal.2024; 48(1): 157.     CrossRef
• Altered Metabolic Phenotypes and Hypothalamic Neuronal Activity Triggered by Sodium-Glucose Cotransporter 2 Inhibition (Diabetes Metab J 2023;47:784-95)
  Ho Gyun Lee, Il Hyeon Jung, Byong Seo Park, Hye Rim Yang, Kwang Kon Kim, Thai Hien Tu, Jung-Yong Yeh, Sewon Lee, Sunggu Yang, Byung Ju Lee, Jae Geun Kim, Il Seong Nam-Goong
  Diabetes & Metabolism Journal.2024; 48(1): 159.     CrossRef

Citations

Citations to this article as recorded by  

• Garlic ( Allium sativum L. ) in diabetes and its complications: Recent advances in mechanisms of action
  Yayi Jiang, Rensong Yue, Guojie Liu, Jun Liu, Bo Peng, Maoyi Yang, Lianxue Zhao, Zihan Li
  Critical Reviews in Food Science and Nutrition.2024; 64(16): 5290.     CrossRef
• White-brown adipose tissue interplay in polycystic ovary syndrome: Therapeutic avenues
  Khadijeh Abbasi, Reza Zarezadeh, Amir Valizadeh, Amir Mehdizadeh, Hamed Hamishehkar, Mohammad Nouri, Masoud Darabi
  Biochemical Pharmacology.2024; 220: 116012.     CrossRef
• Brown Adipose Tissue, Batokines, and Bioactive Compounds in Foods: An Update
  Fabiane Ferreira Martins, Bruna Cadete Martins, Ananda Vitoria Silva Teixeira, Matheus Ajackson, Vanessa Souza‐Mello, Julio Beltrame Daleprane
  Molecular Nutrition & Food Research.2024;[Epub]     CrossRef
• Plasticity of Adipose Tissues: Interconversion among White, Brown, and Beige Fat and Its Role in Energy Homeostasis
  Yanqiu Peng, Lixia Zhao, Min Li, Yunfei Liu, Yuke Shi, Jian Zhang
  Biomolecules.2024; 14(4): 483.     CrossRef
• Homotaurine exhibits contrasting effects of DRD1-mediated thermogenesis-related regulators in C2C12 myoblasts and 3T3−L1 white adipocytes
  Kiros Haddish, Jong Won Yun
  Biotechnology and Bioprocess Engineering.2024; 29(4): 673.     CrossRef
• The role of brown adipose tissue in mediating healthful longevity
  Jie Zhang, Berhanu Geresu Kibret, Dorothy E. Vatner, Stephen F. Vatner
  The Journal of Cardiovascular Aging.2024;[Epub]     CrossRef
• Genipin improves obesity through promoting bile secretion and changing bile acids composition in diet-induced obese rats
  Lili Guan, Lei Zhang, Dezheng Gong, Pengcheng Li, Shengnan Zhu, Jiulan Tang, Man Du, Maokun Zhang, Yuan Zou
  Journal of Pharmacy and Pharmacology.2024; 76(7): 897.     CrossRef
• N-3 polyunsaturated fatty acids in fat-1 transgenic mice prevent obesity by stimulating the IL-27 signaling pathway
  Jiayao Bai, Yinlin Ge, Changqi Zhao, Liu Yang, Keli Ge, Jinyu Zhang
  Journal of Functional Foods.2024; 118: 106288.     CrossRef
• Genetic variation in NOTCH1 is associated with overweight and obesity in Brazilian elderly
  Estevão Carlos Silva Barcelos, Michel Satya Naslavsky, Izadora Silveira Fernandes, Marilia Oliveira Scliar, Guilherme Lopes Yamamoto, Jaqueline Yu Ting Wang, Laís Bride, Valdemir Pereira de Sousa, Lucia Helena Sagrillo Pimassoni, Paolo Sportoletti, Flavia
  Scientific Reports.2024;[Epub]     CrossRef
• The Metabolic Syndrome: An Overview and Proposed Mechanisms
  Fernanda Santos Thomaz, Oliver Dean John, Payel Sinha, Siti Raihanah Shafie, Simon Worrall
  Obesities.2024; 4(3): 226.     CrossRef
• A Closer Look into White Adipose Tissue Biology and the Molecular Regulation of Stem Cell Commitment and Differentiation
  Presley D. Dowker-Key, Praveen Kumar Jadi, Nicholas B. Gill, Katelin N. Hubbard, Ahmed Elshaarrawi, Naba D. Alfatlawy, Ahmed Bettaieb
  Genes.2024; 15(8): 1017.     CrossRef
• Identification of regulatory networks and crosstalk factors in brown adipose tissue and liver of a cold-exposed cardiometabolic mouse model
  Melina Amor, Malena Diaz, Valentina Bianco, Monika Svecla, Birgit Schwarz, Silvia Rainer, Anita Pirchheim, Laszlo Schooltink, Suravi Mukherjee, Gernot F. Grabner, Giangiacomo Beretta, Claudia Lamina, Giuseppe Danilo Norata, Hubert Hackl, Dagmar Kratky
  Cardiovascular Diabetology.2024;[Epub]     CrossRef
• Thermogenic Brown Fat in Humans: Implications in Energy Homeostasis, Obesity and Metabolic Disorders
  Masayuki Saito, Yuko Okamatsu-Ogura
  The World Journal of Men's Health.2023; 41(3): 489.     CrossRef
• Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
  Min Jeong Park, Kyung Mook Choi
  Metabolism.2023; 144: 155577.     CrossRef
• White adipose tissue undergoes browning during preweaning period in association with microbiota formation in mice
  Anju Tsukada, Yuko Okamatsu-Ogura, Emi Futagawa, Yuki Habu, Natsumi Takahashi, Mira Kato-Suzuki, Yuko Kato, Satoshi Ishizuka, Kei Sonoyama, Kazuhiro Kimura
  iScience.2023; 26(7): 107239.     CrossRef
• In situ fluorescence-photoacoustic measurement of the changes of brown adipose tissue in mice under hindlimb unloading
  Baojie Gong, Jianxin Tang, Xiaoxiao Jiang, Zhe Zhang, Shiying Li, Hongjun Jin, Liming Nie, Guojia Huang
  Journal of Applied Physiology.2023; 135(2): 251.     CrossRef
• Age-Related Expression Dynamics of Uncoupling Protein 1 in Adipose Tissues of ICR Outbred Mice during Postnatal Ontogenesis
  A. V. Yakunenkov, E. I. Elsukova, I. O. Natochy
  Journal of Evolutionary Biochemistry and Physiology.2023; 59(4): 1020.     CrossRef
• Brown adipose tissue evaluation using water and triglyceride as indices by diffuse reflectance spectroscopy
  Tomomi Iida, Yukio Ueda, Hideo Tsukada, Dai Fukumoto, Takafumi Hamaoka
  Journal of Biophotonics.2023;[Epub]     CrossRef
• UNCOUPLING PROTEIN UCP1 EXPRESSION DYNAMICS IN ADIPOSE TISSUES OF THE OUTBRED ICR MICE IN POSTNATAL ONTOGENESIS
  A. V. Yakunenkov, E. I. Elsukova, I. O. Natochy
  Журнал эволюционной биохимии и физиологии.2023; 59(4): 255.     CrossRef
• Antibodies Regulate Dual-Function Enzyme IYD to Induce Functional Synergy between Metabolism and Thermogenesis
  Sunghyun Kang, Hwan-Woo Park, Kyung Ho Han
  International Journal of Molecular Sciences.2022; 23(14): 7834.     CrossRef
• Machine learning-featured Secretogranin V is a circulating diagnostic biomarker for pancreatic adenocarcinomas associated with adipopenia
  Yunju Jo, Min-Kyung Yeo, Tam Dao, Jeongho Kwon, Hyon‐Seung Yi, Dongryeol Ryu
  Frontiers in Oncology.2022;[Epub]     CrossRef
• Possible roles of exercise and apelin against pregnancy complications
  Hamed Alizadeh Pahlavani
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Relationships between the expression of adipose genes and profiles of hospitalized dogs
  Yukina Sugiyama, Fumie Shimokawa, Kazutoshi Sugiyama, Takashi Kobayashi, Yusuke Yamashita, Kei Kazama, Ken Onda, Masayuki Funaba, Masaru Murakami
  Veterinary Research Communications.2022; 46(4): 1239.     CrossRef
• Fruit of Gardenia jasminoides Induces Mitochondrial Activation and Non-Shivering Thermogenesis through Regulation of PPARγ
  Woo Yong Park, Gahee Song, Ja Yeon Park, Kwan-Il Kim, Kwang Seok Ahn, Hyun Jeong Kwak, Jungtae Leem, Jae-Young Um, Jinbong Park
  Antioxidants.2021; 10(9): 1418.     CrossRef

Over a hundred billion bacteria are found in human intestines. This has emerged as an environmental factor in metabolic diseases, such as obesity and related diseases. The majority of these bacteria belong to two dominant phyla, Bacteroidetes and Firmicutes. Since the ratio of Firmicutes to Bacteroidetes increases in people with obesity and in various animal models, it has been assumed that phylum composition causes the increase in occurrence of metabolic diseases over the past decade. However, this assumption has been challenged by recent studies that have found even an opposite association of phylum composition within metabolic diseases. Moreover, the gut microbiota affects host energy metabolism in various ways including production of metabolites and interaction with host intestinal cells to regulate signaling pathways that affect energy metabolism. However, the direct effect of gut bacteria on host energy intake, such as energy consumption by the bacteria itself and its effects on intestinal energy absorption, has been underestimated. This review aims to discuss whether increased ratio of Firmicutes to Bacteroidetes is associated with the development of metabolic diseases, and whether energy competition between the bacteria and host is a missing part of the mechanism linking gut microbiota to metabolic diseases.

Citations

Citations to this article as recorded by  

• Behavior, intestinal health, and growth of small sea cucumbers Apostichopus japonicus in different color morphs
  Peng Ding, Yushi Yu, Zihe Zhao, Xiang Li, Xiajing Wang, Huiyan Wang, Xiyuan Huang, Jun Ding, Chong Zhao
  Marine Environmental Research.2024; 193: 106300.     CrossRef
• Traditional Chinese Medicine formula Dai-Zong-Fang alleviating hepatic steatosis in db/db mice via gut microbiota modulation
  Li-Wei Zhang, Li-Li Zhu, Xiao-Yun Zhu, Shou-Qiang Fu, Xi-Ming Liu
  Frontiers in Pharmacology.2024;[Epub]     CrossRef
• Repeated inoculation with rumen fluid accelerates the rumen bacterial transition with no benefit on production performance in postpartum Holstein dairy cows
  Fanlin Kong, Feiran Wang, Yijia Zhang, Shuo Wang, Wei Wang, Shengli Li
  Journal of Animal Science and Biotechnology.2024;[Epub]     CrossRef
• Combining bioinformatics and multiomics strategies to investigate the key microbiota and active components of Liupao tea ameliorating hyperlipidemia
  Hailin Zhou, Xuancheng Wang, Zhiyong She, Li Huang, Huijie Wei, Shanyi Yang, Zhijuan Wei, Hongwei Chen, Bao Yang, Zehua Hu, Xue Feng, Pingchuan Zhu, Zijian Li, Jiahui Shen, Huan Liu, Huanxiao Dong, Guanghui Chen, Qisong Zhang
  Journal of Ethnopharmacology.2024; 333: 118438.     CrossRef
• Petunidin-3-O-[rhamnopyranosyl-(trans-p-coumaroyl)]-5-O-(β-D-glucopyranoside), the main anthocyanin from the fruits of Lycium ruthenicum murray, enhances the lifespan of Caenorhabditis elegans by activating DAF-16 and improving the gut microbiota
  Kangzhi Zhang, Jiahao Zhu, Peiyun Liu, Renpeng Guo, Yamei Yan, Jia Mi, Lu Lu, Youlong Cao, Xiaoxiong Zeng
  Food Bioscience.2024; 61: 104642.     CrossRef
• Exploring the Gut Microbiota: Key Insights Into Its Role in Obesity, Metabolic Syndrome, and Type 2 Diabetes
  Sabitha Sasidharan Pillai, Charles A Gagnon, Christy Foster, Ambika P Ashraf
  The Journal of Clinical Endocrinology & Metabolism.2024;[Epub]     CrossRef
• Effect of Saccharomyces boulardii on Liver Diseases: A Systematic Review
  Roman Maslennikov, Nona Benuni, Anna Levshina, Farida Adzhieva, Tatyana Demina, Alina Kucher, Ekaterina Pervushova, Evgeniya Yuryeva, Elena Poluektova, Oxana Zolnikova, Evgenii Kozlov, Alexey Sigidaev, Vladimir Ivashkin
  Microorganisms.2024; 12(8): 1678.     CrossRef
• Testosterone treatment impacts the intestinal microbiome of transgender individuals
  Rebecca M. Harris, Fernanda Pace, Thomas M. Kuntz, Xochitl C. Morgan, Phoebe Hyland, Kiana Summers, Em McDermott, Kai Blumen, Paula I. Watnick, Vincent B. Young
  mSphere.2024;[Epub]     CrossRef
• Analysis of Oral Microbiota in Elderly Thai Patients with Alzheimer’s Disease and Mild Cognitive Impairment
  Narongrit Sritana, Atitaya Phungpinij
  International Journal of Environmental Research and Public Health.2024; 21(9): 1242.     CrossRef
• Identification of oncogenic signatures in the inflammatory colon of C57BL/6 mice fed a high-fat diet
  Huawei Zeng, Bryan D. Safratowich, Wen-Hsing Cheng, Michael R. Bukowski
  The Journal of Nutritional Biochemistry.2023; 111: 109188.     CrossRef
• Evaluation of the gut microbiome alterations in healthy rats after dietary exposure to different synthetic ZnO nanoparticles
  Xinyi Zhu, Henghui Li, Liuzhu Zhou, Huijun Jiang, Minghui Ji, Jin Chen
  Life Sciences.2023; 312: 121250.     CrossRef
• Microplastic-induced gut microbiota and serum metabolic disruption in Sprague-Dawley rats
  Nan Zhao, Meirong Zhao, Hangbiao Jin
  Environmental Pollution.2023; 320: 121071.     CrossRef
• Effects of neutral polysaccharide from Platycodon grandiflorum on high-fat diet-induced obesity via the regulation of gut microbiota and metabolites
  Jing Song, Qin liu, Mengqi Hao, Xiaohu Zhai, Juan Chen
  Frontiers in Endocrinology.2023;[Epub]     CrossRef
• Metabolite interactions between host and microbiota during health and disease: Which feeds the other?
  Yan Zhang, Rui Chen, DuoDuo Zhang, Shuang Qi, Yan Liu
  Biomedicine & Pharmacotherapy.2023; 160: 114295.     CrossRef
• Connecting Gut Microbial Diversity with Plasma Metabolome and Fecal Bile Acid Changes Induced by the Antibiotics Tobramycin and Colistin Sulfate
  Aishwarya Murali, Varun Giri, Franziska Maria Zickgraf, Philipp Ternes, Hunter James Cameron, Saskia Sperber, Volker Haake, Peter Driemert, Hennicke Kamp, Dorothee Funk-Weyer, Shana J. Sturla, Ivonne M.C.M. Rietjens, Bennard van Ravenzwaay
  Chemical Research in Toxicology.2023; 36(4): 598.     CrossRef
• Short-Term Alternate Feeding between Terrestrially Sourced Oil- and Fish Oil-Based Diets Modulates the Intestinal Microecology of Juvenile Turbot
  Xiuhua Ma, Yaoyao Kong, Houguo Xu, Qingzhu Bi, Mengqing Liang, Kangsen Mai, Yanjiao Zhang
  Biology.2023; 12(5): 650.     CrossRef
• Effects and action mechanisms of lotus leaf (Nelumbo nucifera) ethanol extract on gut microbes and obesity in high-fat diet-fed rats
  Zhang Yanan, Ma Lu, Zhang Lu, Huo Jinhai, Wang Weiming
  Frontiers in Nutrition.2023;[Epub]     CrossRef
• Effects of coffee with different roasting degrees on obesity and related metabolic disorders
  Claudia I. Gamboa-Gómez, Laura J. Barragán-Zúñiga, Fernando Guerrero-Romero, Gerardo Martínez-Aguilar, José Luis Gónzalez, Almendra A. Valenzuela-Ramírez, Juan A. Rojas-Contreras, Monica Anese, Maribel Cervantes Flores, Marilisa Alongi
  Journal of Functional Foods.2023; 111: 105889.     CrossRef
• Gut Microbiota and Bacterial Translocation in the Pathogenesis of Liver Fibrosis
  Roman Maslennikov, Elena Poluektova, Oxana Zolnikova, Alla Sedova, Anastasia Kurbatova, Yulia Shulpekova, Natyia Dzhakhaya, Svetlana Kardasheva, Maria Nadinskaia, Elena Bueverova, Vladimir Nechaev, Anna Karchevskaya, Vladimir Ivashkin
  International Journal of Molecular Sciences.2023; 24(22): 16502.     CrossRef
• Eugenol, A Major Component of Clove Oil, Attenuates Adiposity, and Modulates Gut Microbiota in High‐Fat Diet‐Fed Mice
  Mengjie Li, Yuhan Zhao, Yanan Wang, Ruixuan Geng, Jingjing Fang, Seong‐Gook Kang, Kunlun Huang, Tao Tong
  Molecular Nutrition & Food Research.2022;[Epub]     CrossRef
• Heimao tea polysaccharides ameliorate obesity by enhancing gut microbiota-dependent adipocytes thermogenesis in mice fed with high fat diet
  Yu Wang, Ting Li, Yueyue Liu, Chengcheng Yang, Lei Liu, Xiangnan Zhang, Xingbin Yang
  Food & Function.2022; 13(24): 13014.     CrossRef
• The Interplay of Sex Steroids, the Immune Response, and the Intestinal Microbiota
  Fernanda Pace, Paula I. Watnick
  Trends in Microbiology.2021; 29(9): 849.     CrossRef
• Heat stress on microbiota composition, barrier integrity, and nutrient transport in gut, production performance, and its amelioration in farm animals
  Amlan Kumar Patra, Indrajit Kar
  Journal of Animal Science and Technology.2021; 63(2): 211.     CrossRef
• Mechanisms linking gut microbial metabolites to insulin resistance
  Hye Rim Jang, Hui-Young Lee
  World Journal of Diabetes.2021; 12(6): 730.     CrossRef
• The impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health
  Lenka Tomasova, Marian Grman, Karol Ondrias, Marcin Ufnal
  Nutrition & Metabolism.2021;[Epub]     CrossRef

Citations

Citations to this article as recorded by  

• Natural compounds as obesity pharmacotherapies
  Xin‐Yuan Zhao, Ji‐Qiu Wang, G. Gregory Neely, Yan‐Chuan Shi, Qiao‐Ping Wang
  Phytotherapy Research.2024; 38(2): 797.     CrossRef
• Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential
  Jia Gu, Ya-Ning Shi, Neng Zhu, Hong-Fang Li, Chan-Juan Zhang, Li Qin
  Biomedicine & Pharmacotherapy.2023; 164: 114981.     CrossRef
• Tripterygium hypoglaucum extract ameliorates adjuvant-induced arthritis in mice through the gut microbiota
  Jianghui HU, Jimin NI, Junping ZHENG, Yanlei GUO, Yong YANG, Cheng YE, Xiongjie SUN, Hui XIA, Yanju LIU, Hongtao LIU
  Chinese Journal of Natural Medicines.2023; 21(10): 730.     CrossRef
• Health improvements of type 2 diabetic patients through diet and diet plus fecal microbiota transplantation
  Lili Su, Zhifan Hong, Tong Zhou, Yuanyuan Jian, Mei Xu, Xuanping Zhang, Xiaoyan Zhu, Jiayin Wang
  Scientific Reports.2022;[Epub]     CrossRef
• Tripterygium hypoglaucum (Levl.) Hutch: A systematic review of its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics and toxicology
  Jiangping Wei, Liyun Chen, Sijia Gao, Jirui Wang, Yunhong Wang, Zhiwei Zhang, Yuyu Zhang, Xiaomei Zhang, Yong Yang, Dajian Yang
  Pharmacological Research - Modern Chinese Medicine.2022; 3: 100094.     CrossRef
• Celastrol: An Update on Its Hepatoprotective Properties and the Linked Molecular Mechanisms
  Mengzhen Li, Faren Xie, Lu Wang, Guoxue Zhu, Lian-Wen Qi, Shujun Jiang
  Frontiers in Pharmacology.2022;[Epub]     CrossRef
• Celastrol inhibits the proliferation and migration of MCF-7 cells through the leptin-triggered PI3K/AKT pathway
  Pingping Chen, Bin Wang, Meng Li, Chunxue Cui, Fei Liu, Yonggang Gao
  Computational and Structural Biotechnology Journal.2022; 20: 3173.     CrossRef
• Investigating Celastrol’s Anti-DCM Targets and Mechanisms via Network Pharmacology and Experimental Validation
  Rui Xi, Yongxin Wan, Lihong Yang, Jingying Zhang, Liu Yang, Shuai Yang, Rui Chai, Fengchen Mu, Qiting Sun, Rui Yan, Zhifang Wu, Sijin Li, Zhijun Liao
  BioMed Research International.2022; 2022: 1.     CrossRef
• Celastrol inhibits TXNIP expression to protect pancreatic β cells in diabetic mice
  Si-wei Wang, Tian Lan, Fang Zheng, Hui Huang, Hang-fei Chen, Qi Wu, Feng Zhang
  Phytomedicine.2022; 104: 154316.     CrossRef
• Celastrol: A Promising Agent Fighting against Cardiovascular Diseases
  Zhexi Li, Jingyi Zhang, Xulei Duan, Guoan Zhao, Min Zhang
  Antioxidants.2022; 11(8): 1597.     CrossRef
• Celastrol: A lead compound that inhibits SARS‐CoV‐2 replication, the activity of viral and human cysteine proteases, and virus‐induced IL‐6 secretion
  Carlos A. Fuzo, Ronaldo B. Martins, Thais F. C. Fraga‐Silva, Martin K. Amstalden, Thais Canassa De Leo, Juliano P. Souza, Thais M. Lima, Lucia H. Faccioli, Débora Noma Okamoto, Maria Aparecida Juliano, Suzelei C. França, Luiz Juliano, Vania L. D. Bonato,
  Drug Development Research.2022; 83(7): 1623.     CrossRef
• In vitro activity of celastrol in combination with thymol against carbapenem-resistant Klebsiella pneumoniae isolates
  Mahmoud Saad Abdel-Halim, Momen Askoura, Basem Mansour, Galal Yahya, Amira M. El-Ganiny
  The Journal of Antibiotics.2022; 75(12): 679.     CrossRef
• Celastrol alleviates metabolic disturbance in high‐fat diet‐induced obese mice through increasing energy expenditure by ameliorating metabolic inflammation
  Xueping Yang, Fan Wu, Lingli Li, Ernest C. Lynch, Linglin Xie, Yan Zhao, Ke Fang, Jingbin Li, Jinlong Luo, Lijun Xu, Xin Zou, Fuer Lu, Guang Chen
  Phytotherapy Research.2021; 35(1): 297.     CrossRef
• Celastrol in metabolic diseases: Progress and application prospects
  Shaohua Xu, Yaqian Feng, Weishen He, Wen Xu, Wei Xu, Hongjun Yang, Xianyu Li
  Pharmacological Research.2021; 167: 105572.     CrossRef
• The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism
  Qijing Fan, Furong Xu, Bin Liang, Xiaoju Zou
  Frontiers in Pharmacology.2021;[Epub]     CrossRef
• Serum Metabolome Mediates the Antiobesity Effect of Celastrol-Induced Gut Microbial Alterations
  Shaohua Xu, Liwei Lyu, Huaichang Zhu, Xiaoqiang Huang, Wei Xu, Wen Xu, Yaqian Feng, Yong Fan
  Journal of Proteome Research.2021; 20(10): 4840.     CrossRef
• Interrelated Mechanism by Which the Methide Quinone Celastrol, Obtained from the Roots of Tripterygium wilfordii, Inhibits Main Protease 3CLpro of COVID-19 and Acts as Superoxide Radical Scavenger
  Francesco Caruso, Manrose Singh, Stuart Belli, Molly Berinato, Miriam Rossi
  International Journal of Molecular Sciences.2020; 21(23): 9266.     CrossRef

Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription coactivator (CRTC), is essential for controlling the expression of critical enzymes in the metabolic process, leading to more chronic changes in metabolic flux. Among the CRTC isoforms, CRTC2 is predominantly expressed in peripheral tissues and has been shown to be associated with various metabolic pathways in tissue-specific manners. While initial reports showed the physiological role of CRTC2 in regulating gluconeogenesis in the liver, recent studies have further delineated the role of this transcriptional coactivator in the regulation of glucose and lipid metabolism in various tissues, including the liver, pancreatic islets, endocrine tissues of the small intestines, and adipose tissues. In this review, we discuss recent studies that have utilized knockout mouse models to delineate the role of CRTC2 in the regulation of metabolic homeostasis.

Citations

Citations to this article as recorded by  

• Integration of genomic and transcriptomic data of inbred mouse models for polygenic obesity and leanness revealed “obese” and “lean” candidate alleles in polyadenylation signals
  Martin Šimon, Špela Mikec, Nicholas M. Morton, Santosh S. Atanur, Simon Horvat, Tanja Kunej
  Gene Reports.2024; 35: 101903.     CrossRef
• Molecular characterization, spatio-temporal expression patterns of crtc2 gene and its immune roles in yellow catfish (Pelteobagrus fulvidraco)
  Wan-Hong Zeng, Zheng-Yong Wen, Xiu-Ying Wei, Yu He, Luo Zhou, Peng Hu, Qing-Chao Shi, Chuan-Jie Qin, Jun Wang, Rui Li, Xiao-Ying Jing, Wei Hu, Han-Wen Yuan, Jun-De Fan, Chuang Zhang, Wei Jiang, Peng Fu, Qiong Shi
  Fish & Shellfish Immunology.2024; 154: 109877.     CrossRef
• Mylabris phalerata induces the apoptosis and cell cycle delay in HCC, and potentiates the effect of sorafenib based on the molecular and network pharmacology approach
  Young Woo Kim, Seon Been Bak, Su Youn Baek, Il Kon Kim, Won-Yung Lee, Un-Jung Yun, Kwang-Il Park
  Molecular & Cellular Toxicology.2023; 19(4): 731.     CrossRef
• Emerging Role of SMILE in Liver Metabolism
  Nanthini Sadasivam, Kamalakannan Radhakrishnan, Hueng-Sik Choi, Don-Kyu Kim
  International Journal of Molecular Sciences.2023; 24(3): 2907.     CrossRef
• PIMT regulates hepatic gluconeogenesis in mice
  Bandish Kapadia, Soma Behera, Sireesh T. Kumar, Tapan Shah, Rebecca Kristina Edwin, Phanithi Prakash Babu, Partha Chakrabarti, Kishore V.L. Parsa, Parimal Misra
  iScience.2023; 26(3): 106120.     CrossRef
• Biological functions of CRTC2 and its role in metabolism-related diseases
  Hong-Yu Zheng, Yan-Xia Wang, Kun Zhou, Hai-Lin Xie, Zhong Ren, Hui-Ting Liu, Yang-Shao Ou, Zhi-Xiang Zhou, Zhi-Sheng Jiang
  Journal of Cell Communication and Signaling.2023; 17(3): 495.     CrossRef
• An insulin-regulated arrestin domain protein controls hepatic glucagon action
  Sezin Dagdeviren, Megan F. Hoang, Mohsen Sarikhani, Vanessa Meier, Jake C. Benoit, Marinna C. Okawa, Veronika Y. Melnik, Elisabeth M. Ricci-Blair, Natalie Foot, Randall H. Friedline, Xiaodi Hu, Lauren A. Tauer, Arvind Srinivasan, Maxim B. Prigozhin, Sudha
  Journal of Biological Chemistry.2023; 299(8): 105045.     CrossRef
• The Pleiotropic Face of CREB Family Transcription Factors
  Md. Arifur Rahman Chowdhury, Jungeun An, Sangyun Jeong
  Molecules and Cells.2023; 46(7): 399.     CrossRef
• It is a branched road to adipose tissue aging
  N. Touitou, B. Lerrer, H. Y. Cohen
  Nature Aging.2023; 3(8): 911.     CrossRef
• Impaired BCAA catabolism in adipose tissues promotes age-associated metabolic derangement
  Hye-Sook Han, Eunyong Ahn, Eun Seo Park, Tom Huh, Seri Choi, Yongmin Kwon, Byeong Hun Choi, Jueun Lee, Yoon Ha Choi, Yujin L. Jeong, Gwang Bin Lee, Minji Kim, Je Kyung Seong, Hyun Mu Shin, Hang-Rae Kim, Myeong Hee Moon, Jong Kyoung Kim, Geum-Sook Hwang, S
  Nature Aging.2023; 3(8): 982.     CrossRef
• Exploring the diagnostic value, prognostic value, and biological functions of NPC gene family members in hepatocellular carcinoma based on a multi-omics analysis
  Keheng Chen, Xin Zhang, Huixin Peng, Fengdie Huang, Guangyu Sun, Qijiang Xu, Lusheng Liao, Zhiyong Xing, Yanping Zhong, Zhichao Fang, Meihua Liao, Shihua Luo, Wencheng Chen, Mingyou Dong
  Functional & Integrative Genomics.2023;[Epub]     CrossRef
• MicroRNA regulation of AMPK in nonalcoholic fatty liver disease
  Hao Sun, Jongsook Kim Kemper
  Experimental & Molecular Medicine.2023; 55(9): 1974.     CrossRef
• Serine active site containing protein 1 depletion alters lipid metabolism and protects against high fat diet-induced obesity in mice
  Miaomiao Du, Xueyun Li, Fangyi Xiao, Yinxu Fu, Yu Shi, Sihan Guo, Lifang Chen, Lu Shen, Lan Wang, Huang Cheng, Hao Li, Anran Xie, Yaping Zhou, Kaiqiang Yang, Hezhi Fang, Jianxin Lyu, Qiongya Zhao
  Metabolism.2022; 134: 155244.     CrossRef
• cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach
  Muhammad Bilal Ahmed, Abdullah A. A. Alghamdi, Salman Ul Islam, Joon-Seok Lee, Young-Sup Lee
  Cells.2022; 11(13): 2020.     CrossRef
• Hepatic Sam68 Regulates Systemic Glucose Homeostasis and Insulin Sensitivity
  Aijun Qiao, Wenxia Ma, Ying Jiang, Chaoshan Han, Baolong Yan, Junlan Zhou, Gangjian Qin
  International Journal of Molecular Sciences.2022; 23(19): 11469.     CrossRef
• The Role of Small Heterodimer Partner-Interacting Leucine Zipper (SMILE) as a Transcriptional Corepressor in Hepatic Glucose and Lipid Metabolism
  Woo-Ram Park, Byungyoon Choi, Nanthini Sadasivam, Don-Kyu Kim
  Trends in Agriculture & Life Sciences.2022; 60: 7.     CrossRef
• AMPK Localization: A Key to Differential Energy Regulation
  Qonita Afinanisa, Min Kyung Cho, Hyun-A Seong
  International Journal of Molecular Sciences.2021; 22(20): 10921.     CrossRef

Chronic energy surplus increases body fat, leading to obesity. Since obesity is closely associated with most metabolic complications, pathophysiological roles of adipose tissue in obesity have been intensively studied. White adipose tissue is largely divided into subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). These two white adipose tissues are similar in their appearance and lipid storage functions. Nonetheless, emerging evidence has suggested that SAT and VAT have different characteristics and functional roles in metabolic regulation. It is likely that there are intrinsic differences between VAT and SAT. In diet-induced obese animal models, it has been reported that adipogenic progenitors in VAT rapidly proliferate and differentiate into adipocytes. In obesity, VAT exhibits elevated inflammatory responses, which are less prevalent in SAT. On the other hand, SAT has metabolically beneficial effects. In this review, we introduce recent studies that focus on cellular and molecular components modulating adipogenesis and immune responses in SAT and VAT. Given that these two fat depots show different functions and characteristics depending on the nutritional status, it is feasible to postulate that SAT and VAT have different developmental origins with distinct adipogenic progenitors, which would be a key determining factor for the response and accommodation to metabolic input for energy homeostasis.

Citations

Citations to this article as recorded by  

• Lipodystrophy as a target to delay premature aging
  Daniela G. Costa, Marisa Ferreira-Marques, Cláudia Cavadas
  Trends in Endocrinology & Metabolism.2024; 35(2): 97.     CrossRef
• Subcutaneous fat predicts bone metastasis in breast cancer: A novel multimodality-based deep learning model
  Shidi Miao, Haobo Jia, Wenjuan Huang, Ke Cheng, Wenjin Zhou, Ruitao Wang
  Cancer Biomarkers.2024; 39(3): 171.     CrossRef
• Association between abdominal adiposity and clinical outcomes in patients with acute ischemic stroke
  Kayo Wakisaka, Ryu Matsuo, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono, Masaki Mogi
  PLOS ONE.2024; 19(1): e0296833.     CrossRef
• NOTCH1 as a Negative Regulator of Avian Adipocyte Differentiation: Implications for Fat Deposition
  Zheng Wang, Yue Su, Mingyu Zhao, Zhenhua Ma, Jianhui Li, Zhuocheng Hou, Huifeng Li
  Animals.2024; 14(4): 585.     CrossRef
• Visceral adipose of obese mice inhibits endothelial inwardly rectifying K+ channels in a CD36-dependent fashion
  Sabita Rokka, Masoumeh Sadeghinejad, Emma C. Hudgins, Erica J. Johnson, Thanh Nguyen, Ibra S. Fancher
  American Journal of Physiology-Cell Physiology.2024; 326(5): C1543.     CrossRef
• Adipose-derived mesenchymal stromal cells in clinical trials: Insights from single-cell studies
  Anna Kostecka, Natalia Kalamon, Aneta Skoniecka, Magdalena Koczkowska, Piotr M. Skowron, Arkadiusz Piotrowski, Michał Pikuła
  Life Sciences.2024; 351: 122761.     CrossRef
• Dynamics of single-nuclei transcriptomic profiling of adipose tissue from diverse anatomical locations during mouse aging process
  Yujie Wu, Ying Sun, Long Chen, Xingyan Tong, Can Liu, Lu Lu, Rui Zhang, Siyuan Wang, Ziyu Chen, Jiaman Zhang, Ziyin Han, Bo Zeng, Mingzhou Li, Long Jin
  Scientific Reports.2024;[Epub]     CrossRef
• Glucose metabolism and radiodensity of abdominal adipose tissue: A 5‐year longitudinal study in a large PET cohort
  Kyoungjune Pak, Severi Santavirta, Seunghyeon Shin, Hyun‐Yeol Nam, Sven De Maeyer, Lauri Nummenmaa
  Clinical Endocrinology.2024;[Epub]     CrossRef
• Green tea beneficial effects involve changes in the profile of immune cells in the adipose tissue of obese mice
  Kaue Tognolli, Victoria Silva, Celso Pereira Batista Sousa-Filho, Claudia Andrea Lima Cardoso, Renata Gorjão, Rosemari Otton
  European Journal of Nutrition.2023; 62(1): 321.     CrossRef
• Mechanic Insight into the Distinct and Common Roles of Ovariectomy Versus Adrenalectomy on Adipose Tissue Remodeling in Female Mice
  Weihao Chen, Fengyan Meng, Xianyin Zeng, Xiaohan Cao, Guixian Bu, Xiaogang Du, Guozhi Yu, Fanli Kong, Yunkun Li, Tian Gan, Xingfa Han
  International Journal of Molecular Sciences.2023; 24(3): 2308.     CrossRef
• High-fat diet consumption by male rat offspring of obese mothers exacerbates adipose tissue hypertrophy and metabolic alterations in adult life
  Guadalupe L. Rodríguez-González, Sergio De Los Santos, Dayana Méndez-Sánchez, Luis A. Reyes-Castro, Carlos A. Ibáñez, Patricia Canto, Elena Zambrano
  British Journal of Nutrition.2023; 130(5): 783.     CrossRef
• Obesity and the risk of cardiometabolic diseases
  Pedro L. Valenzuela, Pedro Carrera-Bastos, Adrián Castillo-García, Daniel E. Lieberman, Alejandro Santos-Lozano, Alejandro Lucia
  Nature Reviews Cardiology.2023; 20(7): 475.     CrossRef
• Abdominal fat and muscle distributions in different stages of colorectal cancer
  Jun Han, Xinyang Liu, Min Tang, Fan Yang, Zuoyou Ding, Guohao Wu
  BMC Cancer.2023;[Epub]     CrossRef
• Expression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer—Relationship to the Body Mass Index
  Sofía Elena Tesolato, Daniel González-Gamo, Ana Barabash, Paula Claver, Sofía Cristina de la Serna, Inmaculada Domínguez-Serrano, Jana Dziakova, Carmen de Juan, Antonio José Torres, Pilar Iniesta
  Cancers.2023; 15(13): 3324.     CrossRef
• Lower subcutaneous fat index predicts bone metastasis in breast cancer
  Wen Wang, Wen-Juan Huang, Ping-Ping Liu, Shuang Fu, Meng-Lin Zhang, Xin Zhang, Rui-Tao Wang, Yuan-Xi Huang
  Cancer Biomarkers.2023; 38(1): 121.     CrossRef
• RabGAP AS160/TBC1D4 deficiency increases long-chain fatty acid transport but has little additional effect on obesity and metabolic syndrome in ADMSCs-derived adipocytes of morbidly obese women
  Agnieszka Mikłosz, Bartłomiej Łukaszuk, Elżbieta Supruniuk, Kamil Grubczak, Magdalena Kusaczuk, Adrian Chabowski
  Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
• White adipose tissue: Distribution, molecular insights of impaired expandability, and its implication in fatty liver disease
  Griselda Rabadán-Chávez, Rocío I. Díaz de la Garza, Daniel A. Jacobo-Velázquez
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(8): 166853.     CrossRef
• Histological pattern and gene expression profiling of thyroid tissue in subjects with obesity
  A. Basolo, A. M. Poma, R. Giannini, G. Ceccarini, C. Pelosini, P. Fierabracci, M. U. Castany, S. Bechi Genzano, C. E. Ambrosini, G. Materazzi, L. Chiovato, F. Basolo, F. Santini, L. Torregrossa
  Journal of Endocrinological Investigation.2022; 45(2): 413.     CrossRef
• Predictors of non-alcoholic fatty liver disease in children
  Menglong Li, Wen Shu, Jiawulan Zunong, Nubiya Amaerjiang, Huidi Xiao, Dan Li, Sten H. Vermund, Yifei Hu
  Pediatric Research.2022; 92(1): 322.     CrossRef
• Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics
  Hahn Nahmgoong, Yong Geun Jeon, Eun Seo Park, Yoon Ha Choi, Sang Mun Han, Jeu Park, Yul Ji, Jee Hyung Sohn, Ji Seul Han, Ye Young Kim, Injae Hwang, Yun Kyung Lee, Jin Young Huh, Sung Sik Choe, Tae Jung Oh, Sung Hee Choi, Jong Kyoung Kim, Jae Bum Kim
  Cell Metabolism.2022; 34(3): 458.     CrossRef
• WT1 in Adipose Tissue: From Development to Adult Physiology
  Karin M. Kirschner, Holger Scholz
  Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
• Shall We Begin the Voyage of Adipose Tissue Exploration?
  Yong Geun Jeon
  Molecules and Cells.2022; 45(6): 362.     CrossRef
• Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non‐ and anti‐adipogenic in age‐dependent manner
  Magda Zachara, Pernille Y Rainer, Horia Hashimi, Julie M Russeil, Daniel Alpern, Radiana Ferrero, Maria Litovchenko, Bart Deplancke
  The EMBO Journal.2022;[Epub]     CrossRef
• The fates of different types of adipose tissue after transplantation in mice
  Shenglu Jiang, Jiayan Lin, Qian Zhang, Yunjun Liao, Feng Lu, Junrong Cai
  The FASEB Journal.2022;[Epub]     CrossRef
• Analysis of different adipose depot gene expression in cachectic patients with gastric cancer
  Jun Han, Zuoyou Ding, Qiulin Zhuang, Lei Shen, Fan Yang, Szechun Sah, Guohao Wu
  Nutrition & Metabolism.2022;[Epub]     CrossRef
• Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents
  Mariachiara Zuccarini, Patricia Giuliani, Valentina Di Liberto, Monica Frinchi, Francesco Caciagli, Vanni Caruso, Renata Ciccarelli, Giuseppa Mudò, Patrizia Di Iorio
  International Journal of Molecular Sciences.2022; 23(3): 1543.     CrossRef
• Is There a Link between Obesity Indices and Skin Autofluorescence? A Response from the ILERVAS Project
  Enric Sánchez, Marta Sánchez, Carolina López-Cano, Marcelino Bermúdez-López, José Manuel Valdivielso, Cristina Farràs-Sallés, Reinald Pamplona, Gerard Torres, Dídac Mauricio, Eva Castro, Elvira Fernández, Albert Lecube
  Nutrients.2022; 15(1): 203.     CrossRef
• Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?
  Alice Chaplin, Ramon Maria Rodriguez, Juan José Segura-Sampedro, Aina Ochogavía-Seguí, Dora Romaguera, Gwendolyn Barceló-Coblijn
  International Journal of Molecular Sciences.2022; 23(21): 13128.     CrossRef
• Potential effects of nutrition-based weight loss therapies in reversing obesity-related breast cancer epigenetic marks
  Paula M. Lorenzo, Ana B. Crujeiras
  Food & Function.2021; 12(4): 1402.     CrossRef
• Metabolomic Profiles in Adipocytes Differentiated from Adipose-Derived Stem Cells Following Exercise Training or High-Fat Diet
  Seita Osawa, Hisashi Kato, Yuki Maeda, Hisashi Takakura, Junetsu Ogasawara, Tetsuya Izawa
  International Journal of Molecular Sciences.2021; 22(2): 966.     CrossRef
• Adipocytes Are the Control Tower That Manages Adipose Tissue Immunity by Regulating Lipid Metabolism
  Jeu Park, Jee Hyung Sohn, Sang Mun Han, Yoon Jeong Park, Jin Young Huh, Sung Sik Choe, Jae Bum Kim
  Frontiers in Immunology.2021;[Epub]     CrossRef
• Ceramides and Sphingosino-1-Phosphate in Obesity
  Ilona Juchnicka, Mariusz Kuźmicki, Jacek Szamatowicz
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Contribution of Adipose Tissue to the Chronic Immune Activation and Inflammation Associated With HIV Infection and Its Treatment
  Christine Bourgeois, Jennifer Gorwood, Anaelle Olivo, Laura Le Pelletier, Jacqueline Capeau, Olivier Lambotte, Véronique Béréziat, Claire Lagathu
  Frontiers in Immunology.2021;[Epub]     CrossRef
• Subcutaneous, but not visceral, adipose tissue as a marker for prognosis in gastric cancer patients with cachexia
  Jun Han, Min Tang, Chaocheng Lu, Lei Shen, Jiaqi She, Guohao Wu
  Clinical Nutrition.2021; 40(9): 5156.     CrossRef
• miR-410-3P inhibits adipocyte differentiation by targeting IRS-1 in cancer-associated cachexia patients
  Diya Sun, Zuoyou Ding, Lei Shen, Fan Yang, Jun Han, Guohao Wu
  Lipids in Health and Disease.2021;[Epub]     CrossRef
• Multipotent Stromal Cells from Subcutaneous Adipose Tissue of Normal Weight and Obese Subjects: Modulation of Their Adipogenic Differentiation by Adenosine A1 Receptor Ligands
  Mariachiara Zuccarini, Catia Lambertucci, Marzia Carluccio, Patricia Giuliani, Maurizio Ronci, Andrea Spinaci, Rosaria Volpini, Renata Ciccarelli, Patrizia Di Iorio
  Cells.2021; 10(12): 3560.     CrossRef
• Obesity: The Crossroads of Opinion, Knowledge, and Opportunity
  L. A. Ruyatkina, D. S. Ruyatkin
  Meditsinskiy sovet = Medical Council.2020; (7): 108.     CrossRef
• Sex Differences in Long-term Metabolic Effects of Maternal Resveratrol Intake in Adult Rat Offspring
  Purificación Ros, Francisca Díaz, Alejandra Freire-Regatillo, Pilar Argente-Arizón, Vicente Barrios, Jesús Argente, Julie A Chowen
  Endocrinology.2020;[Epub]     CrossRef
• Adipose stem cells in obesity: challenges and opportunities
  Sunhye Shin, Asma S. El-Sabbagh, Brandon E. Lukas, Skylar J. Tanneberger, Yuwei Jiang
  Bioscience Reports.2020;[Epub]     CrossRef
• Clinical and pathogenetic rationale for the prevention and treatment of obesity
  O.M. Korzh
  Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini.2020; 2020(2): 146.     CrossRef
• OBESITY: CLINICAL AND PATHOGENETIC JUSTIFICATION OF PREVENTION AND TREATMENT
  O. M. Korzh
  International Medical Journal.2020; (2): 5.     CrossRef
• The Effect and Mechanism of Subcutaneous and Visceral Adipose Tissue Loss on Gastric Cancer Patients With Cachexia
  Jun Han, Min Tang, Guyue Zhang, Chaocheng Lu, Jiaqi She, Guohao Wu
  SSRN Electronic Journal .2020;[Epub]     CrossRef