Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in subjects with diabetes. Disorders of the physiological signaling functions of reactive oxygen species (superoxide and hydrogen peroxide) and reactive nitrogen species (nitric oxide and peroxynitrite) are important features of diabetes. In the absence of an appropriate compensation by the endogenous antioxidant defense network, increased oxidative stress leads to the activation of stress-sensitive intracellular signaling pathways and the formation of gene products that cause cellular damage and contribute to the vascular complications of diabetes. It has recently been suggested that diabetic subjects with vascular complications may have a defective cellular antioxidant response against the oxidative stress generated by hyperglycemia. This raises the concept that antioxidant therapy may be of great benefit to these subjects. Although our understanding of how hyperglycemia-induced oxidative stress ultimately leads to tissue damage has advanced considerably in recent years, effective therapeutic strategies to prevent or delay the development of this damage remain limited. Thus, further investigation of therapeutic interventions to prevent or delay the progression of diabetic vascular complications is needed.

Citations

Citations to this article as recorded by  

• Relationship of phytochemicals and antioxidant activities in Gymnema inodorum leaf extracts
  Onanong Nuchuchua, Wanwisa Srinuanchai, Chaisak Chansriniyom, Uthaiwan Suttisansanee, Piya Temviriyanukul, Nitra Nuengchamnong, Uracha Ruktanonchai
  Heliyon.2024; 10(1): e23175.     CrossRef
• The Role of Glutathione and Its Precursors in Type 2 Diabetes
  Dawn Tuell, George Ford, Evan Los, William Stone
  Antioxidants.2024; 13(2): 184.     CrossRef
• Combined toxicity of microplastics and copper on Goniopora columns
  Ya-Ting Chen, De-Sing Ding, Yee Cheng Lim, Cheng-Di Dong, Shu-Ling Hsieh
  Environmental Pollution.2024; 345: 123515.     CrossRef
• Catalytic Nanoparticles in Biomedical Applications: Exploiting Advanced Nanozymes for Therapeutics and Diagnostics
  Divinah Manoharan, Liu‐Chun Wang, Ying‐Chi Chen, Wei‐Peng Li, Chen‐Sheng Yeh
  Advanced Healthcare Materials.2024;[Epub]     CrossRef
• Oxidative Stress, Endothelial Dysfunction, and N-Acetylcysteine in Type 2 Diabetes Mellitus
  Xin Li, Junyong Zou, Aiping Lin, Jingshu Chi, Hong Hao, Hong Chen, Zhenguo Liu
  Antioxidants & Redox Signaling.2024; 40(16-18): 968.     CrossRef
• Acacia gum: Chemistry, properties & food applications
  Deepak Mudgil, Sheweta Mudgil
  Food and Humanity.2024; 2: 100264.     CrossRef
• Association between composite dietary antioxidant index and stroke among individuals with diabetes
  Hong-Qiang Zhang, Jie Shi, Tong Yue, Jia-Hao Weng, Xu-Lin Wang, Hao Wang, Xiao-Yu Su, Xue-Ying Zheng, Si-Hui Luo, Yu Ding, Chao-Fan Wang
  World Journal of Diabetes.2024; 15(8): 1742.     CrossRef
• In Vitro and in-silico Anti-diabetic Evaluation of the Combination of Annona squamosa Linn., Leaf Extract and Oleanolic Acid
  Sasmita Dash, Nityananda Sahoo, Gurudutta Pattnaik, Chandan Das, Sovan Pattanaik, Goutam Ghosh, Goutam Rath, Biswakanth Kar
  Current Bioactive Compounds.2024;[Epub]     CrossRef
• The Relationship Between Lycopene and Metabolic Diseases
  Anna Kulawik, Judyta Cielecka-Piontek, Bogusław Czerny, Adam Kamiński, Przemysław Zalewski
  Nutrients.2024; 16(21): 3708.     CrossRef
• The Potential of Neuregulin 4 as a Novel Biomarker and Therapeutic Agent for Vascular Complications in Type 2 Diabetes Mellitus
  Xiaofang Dan, Ke Li, Jiali Xu, Pijun Yan
  Journal of Inflammation Research.2024; Volume 17: 8543.     CrossRef
• High glucose-induced increasing reactive nitrogen species accumulation triggered mitochondrial dysfunction, inflammation, and apoptosis in keratinocytes
  Huma Rizwan, Sonu Kumar, Golden Kumari, Arttatrana Pal
  Life Sciences.2023; 312: 121208.     CrossRef
• Vitamin D–vitamin D receptor alleviates oxidative stress in ischemic acute kidney injury via upregulating glutathione peroxidase 3
  Xueqin Wu, Shiqi Tang, Qing Dai, Bin Yi, Shikun Yang, Jian Sun, Yong Zhong, Wei Lin, Jun Liu, Yan Liu, Jianwen Wang, Jishi Liu, Qin Liao, Wei Zhang, Hao Zhang
  The FASEB Journal.2023;[Epub]     CrossRef
• Characterization, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities of green synthesized silver nanoparticles using Phragmanthera austroarabica A. G. Mill and J. A. Nyberg extract
  Dina M. Khodeer, Ali M. Nasr, Shady A. Swidan, Sarah Shabayek, Roaa M. Khinkar, Mohammed M. Aldurdunji, Maryam A. Ramadan, Jihan M. Badr
  Frontiers in Microbiology.2023;[Epub]     CrossRef
• Toxic Effects of Copper Sulfate and Trichlorfon on the Intestines of Zebrafish (Danio rerio)
  Qing Li, Yangyang Cao, Yuting Wang, Xiaodong Long, Wenbo Sun, Hui Yang, Yingying Zhang, Zhitao Qi
  Aquaculture Research.2023; 2023: 1.     CrossRef
• Early Detection Is the Best Prevention—Characterization of Oxidative Stress in Diabetes Mellitus and Its Consequences on the Cardiovascular System
  Sanela Rajlic, Hendrik Treede, Thomas Münzel, Andreas Daiber, Georg Daniel Duerr
  Cells.2023; 12(4): 583.     CrossRef
• In vitroand computational studies of the antioxidant and anti-diabetic properties ofBridelia ferruginea
  Olajumoke Oyebode, Ochuko Lucky Erukainure, Lindiwe Zuma, Collins U. Ibeji, Neil Anthony Koorbanally, Md. Shahidul Islam
  Journal of Biomolecular Structure and Dynamics.2022; 40(9): 3989.     CrossRef
• Oxidative distress in aging and age-related diseases: Spatiotemporal dysregulation of protein oxidation and degradation
  Sergey Zavadskiy, Susanna Sologova, Nurbubu Moldogazieva
  Biochimie.2022; 195: 114.     CrossRef
• Effects of Smoking on Diabetic Nephropathy
  Yasemin Gündoğdu, İnan Anaforoğlu
  Frontiers in Clinical Diabetes and Healthcare.2022;[Epub]     CrossRef
• Endogenous Protective Factors and Potential Therapeutic Agents for Diabetes-Associated Atherosclerosis
  Chaoqun Wang, Jin Chen, Pin Wang, Shengli Qing, Wenwen Li, Jin Lu
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Antihyperglycemic activity of verbenone and L-arginine in nicotinamide-streptozotocin-induced diabetic mice: in vitro and in vivo studies
  Habibu Tijjani, Abdulkadir Mohammed Danyaro, Ahmed Olatunde, Aminu Umar Kura
  Beni-Suef University Journal of Basic and Applied Sciences.2022;[Epub]     CrossRef
• Comparison of the combined toxicity of polystyrene microplastics and different concentrations of cadmium in zebrafish
  Hui Yang, Zhu Zhu, Yuexuan Xie, Chen Zheng, Zhenyuan Zhou, Tianhao Zhu, Yingying Zhang
  Aquatic Toxicology.2022; 250: 106259.     CrossRef
• “EVALUATION OF HYPERGLYCEMIA INDUCED OXIDATIVE STRESS IN TYPE-2 DIABETIC PATIENT”
  Ameerul Hasan Amir, Faisal Iqubal, Savita Rathor, Afreena Nasir
  INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2022; : 12.     CrossRef
• Evaluation of Anti-Hyperglycemia and Complications of Red and Black Thai Jasmine Rice Cultivars in Streptozotocin-Induced Diabetic Rats
  Nittiya Suwannasom, Chutamas Thepmalee, Krissana Khoothiam, Chonthida Thephinlap
  Molecules.2022; 27(22): 8043.     CrossRef
• p38 MAPK Inhibitor (SB203580) and Metformin Reduces Aortic Protein Carbonyl and Inflammation in Non-obese Type 2 Diabetic Rats
  Nuttikarn Nokkaew, Podsawee Mongkolpathumrat, Ruttanapong Junsiri, Supawit Jindaluang, Nichagron Tualamun, Niya Manphatthanakan, Nareumon Saleesee, Marisa Intasang, Jantira Sanit, Punyanuch Adulyaritthikul, Kantapich Kongpol, Sarawut Kumphune, Nitirut Ner
  Indian Journal of Clinical Biochemistry.2021; 36(2): 228.     CrossRef
• Elucidation of phytochemicals and antioxidants properties ofSasa quelpaertensis
  Hee Chul Ko, Mi Gyeong Jang, Jae-Won Kim, Songyee Baek, Nam Ho Lee, Se-Jae Kim
  International Journal of Food Properties.2021; 24(1): 210.     CrossRef
• Organelle dynamics of endothelial mitochondria in diabetic angiopathy
  Hong Xiang, Ruipeng Song, Jie Ouyang, Ruifang Zhu, Zhihao Shu, Yulan Liu, Xuewen Wang, Dongtao Zhang, Jiangwei Zhao, Hongwei Lu
  European Journal of Pharmacology.2021; 895: 173865.     CrossRef
• Hypoglycemic and antioxidant effects of green tomato ( Physalis ixocarpa Brot.) calyxes’ extracts
  Fernando Guerrero‐Romero, Luis E. Simental‐Mendía, María Inés Guerra Rosas, Víctor Iván Sayago‐Monreal, Juliana Morales Castro, Claudia I. Gamboa‐Gómez
  Journal of Food Biochemistry.2021;[Epub]     CrossRef
• Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide-induced anaemia in rats
  Jamila Abdulhamid Atata, Taiwo Oluwaseun Ayoola, Abdullateef Abiodun Ajadi, Sani Adamu, Aishat O. Olatunji, Khalid Talha Biobaku
  Journal of Complementary and Integrative Medicine.2021; 18(1): 87.     CrossRef
• NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes
  Ilona M. Gora, Anna Ciechanowska, Piotr Ladyzynski
  Cells.2021; 10(2): 314.     CrossRef
• Potential Roles of Endoplasmic Reticulum Stress and Cellular Proteins Implicated in Diabesity
  Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Ismaeel Yunusa, Aishatu Shehu, Lukman Mustapha, Yusuf Wada, Mubarak Hussaini Ahmad, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Siti Safiah Mokhtar, Silvana Hrelia
  Oxidative Medicine and Cellular Longevity.2021;[Epub]     CrossRef
• Inflammation and apoptosis, two key events induced by hyperglycemia mediated reactive nitrogen species in RGC-5 cells
  Sweta Pal, G. Nageswar Rao, Arttatrana Pal
  Life Sciences.2021; 279: 119693.     CrossRef
• The Predictive Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Levels of Diabetic Peripheral Neuropathy
  Meiqiao Chen, Yuyou Zhu, Jumei Wang, Guoping Wang, Yuanbo Wu
  Journal of Pain Research.2021; Volume 14: 2049.     CrossRef
• The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasomes in the Development of Atherosclerosis
  V. V. Pushkarev, L. K. Sokolova, O. I. Kovzun, V. M. Pushkarev, M. D. Tronko
  Cytology and Genetics.2021; 55(4): 331.     CrossRef
• Aging under Pressure: The Roles of Reactive Oxygen and Nitrogen Species (RONS) Production and Aging Skeletal Muscle in Endothelial Function and Hypertension—From Biological Processes to Potential Interventions
  Hollie Speer, Andrew J. McKune
  Antioxidants.2021; 10(8): 1247.     CrossRef
• Natural Antioxidants in New Age-Related Diseases
  Arti Devi, Vagish Dwibedi, Zaved Ahmed Khan
  Revista Brasileira de Farmacognosia.2021; 31(4): 387.     CrossRef
• Potential risks of endoplasmic reticulum stress on vasculopathy in diabetes
  Sagir Mustapha, Mustapha Mohammed, Ismaeel Yunusa, Aida Hanum Ghulam Rasool, Siti Safiah Mokhtar
  Obesity Medicine.2020; 19: 100274.     CrossRef
• Potential roles of Citrulline and watermelon extract on metabolic and inflammatory variables in diabetes mellitus, current evidence and future directions: A systematic review
  Samaneh Azizi, Reza Mahdavi, Elnaz Vaghef‐Mehrabany, Vahid Maleki, Nahid Karamzad, Mehrangiz Ebrahimi‐Mameghani
  Clinical and Experimental Pharmacology and Physiology.2020; 47(2): 187.     CrossRef
• Enzymic polypeptide antioxidant activity and inhibitory activity on α-glucosidase and α-amylase from Paeonia ostii cake
  Huiru Qiao, Xiaojuan Bi, Yuanyuan Zhang, Mengran Liu, Shuchong Zu, Nan Jia, Shougang Jiang, Qi Lu, Yuangang Zu, Yihong Bao
  Industrial Crops and Products.2020; 146: 112158.     CrossRef
• Hypoglycemic and antioxidant properties of konjac ( Amorphophallus konjac ) in vitro and in vivo
  Claudia I. Gamboa‐Gómez, Fernando Guerrero‐Romero, Miguel A. Sánchez‐Meraz, Luis E. Simental‐Mendía
  Journal of Food Biochemistry.2020;[Epub]     CrossRef
• Heme on Pulmonary Malaria: Friend or Foe?
  Tatiana Almeida Pádua, Mariana Conceição Souza
  Frontiers in Immunology.2020;[Epub]     CrossRef
• The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases
  Thomas CW. Chan, Jennifer L. Wilkinson Berka, Devy Deliyanti, Damien Hunter, Adrian Fung, Gerald Liew, Andrew White
  Experimental Eye Research.2020; 201: 108255.     CrossRef
• The Effect of an Atherogenic Diet and Acute Hyperglycaemia on Endothelial Function in Rabbits Is Artery Specific
  Alexander Tacey, Tawar Qaradakhi, Cassandra Smith, Chris Pittappillil, Alan Hayes, Anthony Zulli, Itamar Levinger
  Nutrients.2020; 12(7): 2108.     CrossRef
• Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway
  Xiaoliang Dong, Di Wu, Yihan Zhang, Lingling Jia, Xiaohua Pan, Jia Sun, Li-Long Pan
  Antioxidants.2020; 9(6): 491.     CrossRef
• Immune-Inflammation in Atherosclerosis: A New Twist in an Old Tale
  Atefe Ghamar Talepoor, Hamed Fouladseresht, Shahdad Khosropanah, Mehrnoosh Doroudchi
  Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(4): 525.     CrossRef
• Fabrication of sensitive D-fructose sensor based on facile ternary mixed ZnO/CdO/SnO2 nanocomposites by electrochemical approach
  M.M. Alam, Abdullah M. Asiri, Mohammed M. Rahman, M.A. Islam
  Surfaces and Interfaces.2020; 19: 100540.     CrossRef
• The role of glutathione and glutathione peroxidase in regulating cellular level of reactive oxygen and nitrogen species
  Sheetal Panday, Raghav Talreja, Mahendra Kavdia
  Microvascular Research.2020; 131: 104010.     CrossRef
• Evaluation of the Antioxidant and Antidiabetic Potential of the Poly Herbal Formulation: Identification of Bioactive Factors
  V.V. Sathibabu Uddandrao, Parim Brahmanaidu, Saravanan Ganapathy
  Cardiovascular & Hematological Agents in Medicinal Chemistry.2020; 18(2): 111.     CrossRef
• Rule of UA on Cardiac Myocytes Uric Acid Differently Influence the Oxidative Damage Induced by Acute Exposure of High Level of Glucose in Chicken Cardiac Myocytes
  Xiaolong Sun, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Hai Lin
  Frontiers in Veterinary Science.2020;[Epub]     CrossRef
• Elevated Serum Levels of Ischemia Modified Albumin and Malondialdehyde are Related to Atherogenic Index of Plasma in a Cohort of Prediabetes
  Mervat M. El-Eshmawy, Doaa F. Gad, Azza A. El-Baiomy
  Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(8): 1347.     CrossRef
• Low serum bilirubin levels contribute to the presence and progression of distal symmetrical polyneuropathy in Chinese patients with type 2 diabetes
  J. Jin, W. Wang, T. Gu, C. Chen, J. Sun, W. Chen, Y. Bi, D. Zhu
  Diabetes & Metabolism.2019; 45(1): 47.     CrossRef
• Therapeutic Benefit of Dillenia indica in Diabetes and Its Associated Complications
  Parul Kamboj, Narayan C. Talukdar, Sanjay K. Banerjee
  Journal of Diabetes Research.2019; 2019: 1.     CrossRef
• The impact of xanthine oxidase (XO) on hemolytic diseases
  Heidi M. Schmidt, Eric E. Kelley, Adam C. Straub
  Redox Biology.2019; 21: 101072.     CrossRef
• What is responsible for antioxidant properties of polyphenolic compounds from plants?
  Małgorzata Olszowy
  Plant Physiology and Biochemistry.2019; 144: 135.     CrossRef
• Leucocyte Telomere Length and Glucose Tolerance Status in Mixed-Ancestry South Africans
  Cecil J. Weale, Glenda M. Davison, Gloudina M. Hon, Andre P. Kengne, Rajiv T. Erasmus, Tandi E. Matsha
  Cells.2019; 8(5): 464.     CrossRef
• Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress
  Xiaojuan Yang, Jing Song, Liang-Jun Yan
  Antioxidants.2019; 8(2): 32.     CrossRef
• Cilostazol Attenuates Retinal Oxidative Stress and Inflammation in a Streptozotocin-Induced Diabetic Animal Model
  Po-Ting Yeh, Yu-Hsun Huang, Shu-Wen Chang, Lu-Chun Wang, Chung-May Yang, Wei-Shiung Yang, Chung-Wu Lin, Chang-Hao Yang
  Current Eye Research.2019; 44(3): 294.     CrossRef
• Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1
  Hatem Maamoun, Tarek Benameur, Gianfranco Pintus, Shankar Munusamy, Abdelali Agouni
  Frontiers in Physiology.2019;[Epub]     CrossRef
• Novel Curcumin C66 That Protects Diabetes‐Induced Aortic Damage Was Associated with Suppressing JNK2 and Upregulating Nrf2 Expression and Function
  Cheng Li, Xiao Miao, Shudong Wang, Binay Kumar Adhikari, Xin Wang, Jian Sun, Quan Liu, Qian Tong, Yonggang Wang, Ayman M. Mahmoud
  Oxidative Medicine and Cellular Longevity.2018;[Epub]     CrossRef
• Nebivolol, a β-blocker abrogates streptozotocin-induced behavioral, biochemical, and neurophysiological deficit by attenuating oxidative-nitrosative stress: a possible target for the prevention of diabetic neuropathy
  Naini Bhadri, Rema Razdan, Sumanta Kumar Goswami
  Naunyn-Schmiedeberg's Archives of Pharmacology.2018; 391(2): 207.     CrossRef
• Angiogenic Dysregulation in Pregnancy-Related Hypertension—A Role for Metformin
  Nerolen Soobryan, Saravanakumar Murugesan, Arunagiri Pandiyan, Jagidesa Moodley, Irene Mackraj
  Reproductive Sciences.2018; 25(11): 1531.     CrossRef
• Nutrients and Oxidative Stress: Friend or Foe?
  Bee Ling Tan, Mohd Esa Norhaizan, Winnie-Pui-Pui Liew, Rodrigo Valenzuela
  Oxidative Medicine and Cellular Longevity.2018;[Epub]     CrossRef
• Free radical scavenging, α-glucosidase inhibitory and lipase inhibitory activities of eighteen Sudanese medicinal plants
  Sara Mustafa Idris Elbashir, Hari Prasad Devkota, Mikiyo Wada, Naoki Kishimoto, Masataka Moriuchi, Tsuyoshi Shuto, Shogo Misumi, Hirofumi Kai, Takashi Watanabe
  BMC Complementary and Alternative Medicine.2018;[Epub]     CrossRef
• An Update on Hypertension in Children With Type 1 Diabetes
  Mallory L. Downie, Emma H. Ulrich, Damien G. Noone
  Canadian Journal of Diabetes.2018; 42(2): 199.     CrossRef
• Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling
  Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie L. Conley, Thiagarajan Sairam, Ashutosh Kumar, Ronald P. Mason, Ramalingam Sankaran, John R. Hoidal, Namakkal S. Rajasekaran
  Frontiers in Physiology.2017;[Epub]     CrossRef
• Protective effects of 6-Gingerol on vascular endothelial cell injury induced by high glucose via activation of PI3K-AKT-eNOS pathway in human umbilical vein endothelial cells
  Dan Liu, Mengqing Wu, Yi Lu, Tao Xian, Yupeng Wang, Bowei Huang, Guohua Zeng, Qiren Huang
  Biomedicine & Pharmacotherapy.2017; 93: 788.     CrossRef
• Evaluation of the release profile, stability and antioxidant activity of a proanthocyanidin-rich cinnamon (Cinnamomum zeylanicum) extract co-encapsulated with α-tocopherol by spray chilling
  Fabrício L. Tulini, Volnei B. Souza, Marcelo Thomazini, Marluci P. Silva, Adna P. Massarioli, Severino M. Alencar, Eliria M.J.A. Pallone, Maria I. Genovese, Carmen S. Favaro-Trindade
  Food Research International.2017; 95: 117.     CrossRef
• Modulatory Effect of Achyranthes aspera L., Seeds on Carbohydrates and Protein Bound Enzymes on High Fructose Fed Diet
  Veerappan Ramanathan, Malarvili Thekkumala
  Journal of Pharmacology and Toxicology.2017; 12(3): 154.     CrossRef
• Pyrethroid insecticide lambda-cyhalothrin and its metabolites induce liver injury through the activation of oxidative stress and proinflammatory gene expression in rats following acute and subchronic exposure
  Bakhta Aouey, Mohamed Derbali, Yassine Chtourou, Michèle Bouchard, Abdelmajid Khabir, Hamadi Fetoui
  Environmental Science and Pollution Research.2017; 24(6): 5841.     CrossRef
• Effect of hydroxychloroquine on oxidative/nitrosative status and angiogenesis in endothelial cells under high glucose condition
  Aysa Rezabakhsh, Soheila Montazersaheb, Elahe Nabat, Mehdi Hassanpour, Azadeh Montaseri, Hassan Malekinejad, Ali Akbar Movassaghpour, Reza Rahbarghazi, Alireza Garjani
  BioImpacts.2017; 7(4): 219.     CrossRef
• The Effect of Vitamin E on Oxidative Stress Indicated by Serum Malondialdehyde in Insulin-dependent Type 2 Diabetes Mellitus Patients with Retinopathy
  Irini P. Chatziralli, George Theodossiadis, Prodromos Dimitriadis, Michail Charalambidis, Antonios Agorastos, Zisis Migkos, Nikolaos Platogiannis, Marilita M. Moschos, Panagiotis Theodossiadis, Petros Keryttopoulos
  The Open Ophthalmology Journal.2017; 11(1): 51.     CrossRef
• Association between Fluorescent Advanced Glycation End-Products and Vascular Complications in Type 2 Diabetic Patients
  Alexis Guerin-Dubourg, Maxime Cournot, Cynthia Planesse, Xavier Debussche, Olivier Meilhac, Philippe Rondeau, Emmanuel Bourdon
  BioMed Research International.2017; 2017: 1.     CrossRef
• Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity
  Xiaoting Luo, Jinzi Wu, Siqun Jing, Liang-Jun Yan
  Aging and disease.2016; 7(1): 90.     CrossRef
• İNSAN VE HAYVANLARDA DİABETES MELLİTUS
  Özlem ÖZMEN, Senay TOPSAKAL
  Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi.2016; 1(1): 47.     CrossRef
• The novel mitochondria-targeted hydrogen sulfide (H 2 S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro
  Domokos Gerő, Roberta Torregrossa, Alexis Perry, Alicia Waters, Sophie Le-Trionnaire, Jacqueline L. Whatmore, Mark Wood, Matthew Whiteman
  Pharmacological Research.2016; 113: 186.     CrossRef
• Heated apple juice supplemented with onion has greatly improved nutritional quality and browning index
  Bonggi Lee, Jeong Dae Seo, Jin-Kyu Rhee, Choon Young Kim
  Food Chemistry.2016; 201: 315.     CrossRef
• Inverse association between serum total bilirubin levels and diabetic peripheral neuropathy in patients with type 2 diabetes
  Eun Sook Kim, Sung Won Lee, Eun Young Mo, Sung Dae Moon, Je Ho Han
  Endocrine.2015; 50(2): 405.     CrossRef
• Interactions of short-acting, intermediate-acting and pre-mixed human insulins with free radicals—Comparative EPR examination
  Paweł Olczyk, Katarzyna Komosinska-Vassev, Paweł Ramos, Łukasz Mencner, Krystyna Olczyk, Barbara Pilawa
  International Journal of Pharmaceutics.2015; 490(1-2): 9.     CrossRef
• Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells
  L. F. Heinrich, D. K. Andersen, M. E. Cleasby, C. Lawson
  British Journal of Nutrition.2015; 113(11): 1704.     CrossRef
• Gum Arabic extracts protect against hepatic oxidative stress in alloxan induced diabetes in rats
  Abdelkareem A. Ahmed, Jaafar S. Fedail, Hassan H. Musa, Asghar Ali Kamboh, Amal Z. Sifaldin, Taha H. Musa
  Pathophysiology.2015; 22(4): 189.     CrossRef
• Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits
  J Roganović, LJ Djukić, E Kršljak, N Tanić, D Stojić
  Oral Diseases.2015; 21(5): 634.     CrossRef
• Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relevance in Diabetic Retinopathy
  Michael Anthony Ruiz, Biao Feng, Subrata Chakrabarti, Rong Wen
  PLOS ONE.2015; 10(4): e0123987.     CrossRef
• Anti-hyperglycaemic effect ofPhragmenthera austroarabicaA.G.Mill. & J.A.Nyberg extract in streptozotocin-induced diabetes in rats
  Abeer Hanafy, Jihan M. Badr
  Natural Product Research.2014; 28(24): 2351.     CrossRef
• Functional and morphological changes of the diencephalon vascular endothelium of rats in experimental ischemia-reperfusion injury and diabetes mellitus
  TM Boĭchuk, TP Savchuk
  Fiziolohichnyĭ zhurnal.2014; 59(6): 30.     CrossRef
• Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox
  Paulo Zoé Costa, Raquel Soares
  Life Sciences.2013; 92(22): 1037.     CrossRef
• Oxidative-stress-induced epigenetic changes in chronic diabetic complications
  Biao Feng, Michael Anthony Ruiz, Subrata Chakrabarti
  Canadian Journal of Physiology and Pharmacology.2013; 91(3): 213.     CrossRef
• Effect of α-Linolenic Acid on Streptozotocin-induced Diabetic Retinopathy Indices In Vivo
  Jun-hui Shen, Qi Ma, Shen-grong Shen, Guo-Tong Xu, Undurti N. Das
  Archives of Medical Research.2013; 44(7): 514.     CrossRef
• Antihyperglycemic Effect ofGinkgo bilobaExtract in Streptozotocin-Induced Diabetes in Rats
  Daye Cheng, Bin Liang, Yunhui Li
  BioMed Research International.2013; 2013: 1.     CrossRef

Diabetic vascular complications are among the leading causes of morbidity and mortality in diabetic patients. In the past, many studies have focused on the mechanisms of hyperglycemia-induced chronic vascular complications via the formation of toxic metabolites such as oxidative stress, advanced glycosylated end products, persistent activation of protein kinase C, and increased sorbitol concentrations. However, vascular complications result from imbalances caused by increases in systemic toxic metabolites, such as those that occur under conditions of hyperglycemia and dyslipidemia, and by reductions in endogenous protective factors such as insulin, vascular endothelial growth factor, and platelet derived growth factor. This review outlines some of the evidence supporting the importance of enhancing endogenous regenerative factors.

Citations

Citations to this article as recorded by  

• Ginkgo biloba extracts protect human retinal Müller glial cells from t-BHP induced oxidative damage by activating the AMPK-Nrf2-NQO-1 axis
  Yue Li, Ke Wang, Xue Zhu, Zhengqi Cheng, Ling Zhu, Michael Murray, Fanfan Zhou
  Journal of Pharmacy and Pharmacology.2023; 75(3): 385.     CrossRef
• Role of platelet-derived growth factor c on endothelial dysfunction in cardiovascular diseases
  Adriana Grismaldo, Luis Sobrevia, Ludis Morales
  Biochimica et Biophysica Acta (BBA) - General Subjects.2022; 1866(10): 130188.     CrossRef
• Organic Isothiocyanates as Hydrogen Sulfide Donors
  Alma Martelli, Valentina Citi, Lara Testai, Simone Brogi, Vincenzo Calderone
  Antioxidants & Redox Signaling.2020; 32(2): 110.     CrossRef
• PGC‐1α, a potential therapeutic target against kidney aging
  Gayoung Lee, Md Jamal Uddin, Yoojeong Kim, Minji Ko, Inyoung Yu, Hunjoo Ha
  Aging Cell.2019;[Epub]     CrossRef
• Glucometabolic characteristics and higher vascular complication risk in Korean patients with type 2 diabetes with non-albumin proteinuria
  Yongin Cho, Yong-ho Lee, Eun Seok Kang, Bong-soo Cha, Byung-wan Lee
  Journal of Diabetes and its Complications.2019; 33(8): 585.     CrossRef
• Ameliorative effects of taurine against diabetes: a review
  Inam-u-llah, Fengyuan Piao, Rana Muhammad Aadil, Raheel Suleman, Kaixin Li, Mengren Zhang, Pingan Wu, Muhammad Shahbaz, Zulfiqar Ahmed
  Amino Acids.2018; 50(5): 487.     CrossRef
• Notoginsenoside Fc attenuates high glucose-induced vascular endothelial cell injury via upregulation of PPAR-γ in diabetic Sprague–Dawley rats
  Jingjing Liu, Chunyu Jiang, Xu Ma, Jianbo Wang
  Vascular Pharmacology.2018; 109: 27.     CrossRef
• Grape seed proanthocyanidin extract protects the retina against early diabetic injury by activating the Nrf2 pathway
  YAN SUN, CAIMEI XIU, WEI LIU, YUAN TAO, JIANRONG WANG, YI QU
  Experimental and Therapeutic Medicine.2016; 11(4): 1253.     CrossRef
• Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway
  Wensong Zhang, Yi Li, Hanlu Ding, Yaqin Du, Li Wang
  Renal Failure.2016; 38(7): 1099.     CrossRef
• TNFSF15 Inhibits Blood Retinal Barrier Breakdown Induced by Diabetes
  Feng Jiang, Qingzhong Chen, Liming Huang, Ying Wang, Zhuhong Zhang, Xiangda Meng, Yuanyuan Liu, Chunjie Mao, Fang Zheng, Jingkai Zhang, Hua Yan
  International Journal of Molecular Sciences.2016; 17(5): 615.     CrossRef
• Effect of Triflusal on Primary Vascular Dysregulation Compared with Aspirin: A Double-Blind, Randomized, Crossover Trial
  Sanghoon Shin, Kwang-Joon Kim, In-Jeong Cho, Geu-Ru Hong, Yangsoo Jang, Namsik Chung, Young Min Rah, Hyuk-Jae Chang
  Yonsei Medical Journal.2015; 56(5): 1227.     CrossRef
• NRF2 plays a protective role in diabetic retinopathy in mice
  Zhenhua Xu, Yanhong Wei, Junsong Gong, Hongkwan Cho, James K. Park, Ee-Rah Sung, Hu Huang, Lijuan Wu, Charles Eberhart, James T. Handa, Yunpeng Du, Timothy S. Kern, Rajesh Thimmulappa, Alistair J. Barber, Shyam Biswal, Elia J. Duh
  Diabetologia.2014; 57(1): 204.     CrossRef
• Inhibition of JNK by compound C66 prevents pathological changes of the aorta in STZ‐induced diabetes
  Yucheng Liu, Yonggang Wang, Xiao Miao, Shanshan Zhou, Yi Tan, Guang Liang, Yang Zheng, Quan Liu, Jian Sun, Lu Cai
  Journal of Cellular and Molecular Medicine.2014; 18(6): 1203.     CrossRef
• Sulforaphane Attenuation of Type 2 Diabetes-Induced Aortic Damage Was Associated with the Upregulation of Nrf2 Expression and Function
  Yonggang Wang, Zhiguo Zhang, Wanqing Sun, Yi Tan, Yucheng Liu, Yang Zheng, Quan Liu, Lu Cai, Jian Sun
  Oxidative Medicine and Cellular Longevity.2014; 2014: 1.     CrossRef
• Therapeutic Effect of MG132 on the Aortic Oxidative Damage and Inflammatory Response in OVE26 Type 1 Diabetic Mice
  Xiao Miao, Wenpeng Cui, Weixia Sun, Ying Xin, Bo Wang, Yi Tan, Lu Cai, Lining Miao, Yaowen Fu, Guanfang Su, Yuehui Wang
  Oxidative Medicine and Cellular Longevity.2013; 2013: 1.     CrossRef
• Risk Factors for the Progression of Intima-Media Thickness of Carotid Arteries: A 2-Year Follow-Up Study in Patients with Newly Diagnosed Type 2 Diabetes
  Sang Ouk Chin, Jin Kyung Hwang, Sang Youl Rhee, Suk Chon, You-Cheol Hwang, Seungjoon Oh, Kyu Jeung Ahn, Ho Yeon Chung, Jeong-taek Woo, Sung-Woon Kim, Young Seol Kim, Ja-Heon Kang, In-Kyung Jeong
  Diabetes & Metabolism Journal.2013; 37(5): 365.     CrossRef
• Downregulation of Nrf2 and HO-1 expression contributes to oxidative stress in type 2 diabetes mellitus: A study in Juana Koslay City, San Luis, Argentina
  Susana Siewert, Irma González, Lucas Santillán, Roberto Lucero, Marta S. Ojeda, María S. Gimenez
  Journal of Diabetes Mellitus.2013; 03(02): 71.     CrossRef
• The effect of oral prostaglandin analogue on painful diabetic neuropathy: a double‐blind, randomized, controlled trial
  S. Shin, K. J. Kim, H. ‐J. Chang, B. ‐W. Lee, W. ‐I. Yang, B. ‐S. Cha, D. Choi
  Diabetes, Obesity and Metabolism.2013; 15(2): 185.     CrossRef
• Areca nut procyanidins ameliorate streptozocin-induced hyperglycemia by regulating gluconeogenesis
  Pei-Ling Huang, Chin-Wen Chi, Tsung-Yun Liu
  Food and Chemical Toxicology.2013; 55: 137.     CrossRef
• Serum glycated albumin predicts the progression of carotid arterial atherosclerosis
  Sun Ok Song, Kwang Joon Kim, Byung-Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee
  Atherosclerosis.2012; 225(2): 450.     CrossRef
• Sulforaphane prevention of diabetes-induced aortic damage was associated with the up-regulation of Nrf2 and its down-stream antioxidants
  Xiao Miao, Yang Bai, Weixia Sun, Wenpeng Cui, Ying Xin, Yuehui Wang, Yi Tan, Lining Miao, Yaowen Fu, Guanfang Su, Lu Cai
  Nutrition & Metabolism.2012;[Epub]     CrossRef
• Association between EPCs count and rate of coronary revascularization in asymptomatic type 2 diabetic patients
  Hyun Min Kim, Kwang Joon Kim, Jae Hoon Moon, Hye-Jeong Lee, Min Kyung Chae, Hyuk-Jae Chang, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Young Jin Kim, Byung-Wan Lee
  Acta Diabetologica.2012; 49(6): 413.     CrossRef
• Taurine ameliorates hyperglycemia and dyslipidemia by reducing insulin resistance and leptin level in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term diabetes
  Kyoung Soo Kim, Da Hee Oh, Jung Yeon Kim, Bong Gn Lee, Jeong Soon You, Kyung Ja Chang, Hyunju Chung, Myung Chul Yoo, Hyung-In Yang, Ja-Heon Kang, Yoo Chul Hwang, Kue Jeong Ahn, Ho-Yeon Chung, In-Kyung Jeong
  Experimental & Molecular Medicine.2012; 44(11): 665.     CrossRef
• Inhibition of NF-κB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells
  In-Kyung Jeong, Da Hee Oh, Seung-Joon Park, Ja-Heon Kang, Sunshin Kim, Myung-Shik Lee, Myung-Jun Kim, Yoo-Chul Hwang, Kyu Jeong Ahn, Ho-Yeon Chung, Min-Kyung Chae, Hyung-Joon Yoo
  Experimental and Molecular Medicine.2011; 43(12): 684.     CrossRef

Citations

Citations to this article as recorded by  

• High Glucose and/or Free Fatty Acid Damage Vascular Endothelial Cells via Stimulating of NAD(P)H Oxidase-induced Superoxide Production from Neutrophils
  Sang Soo Kim, Sun Young Kim, Soo Hyung Lee, Yang Ho Kang, In Ju Kim, Yong Ki Kim, Seok Man Son
  Korean Diabetes Journal.2009; 33(2): 94.     CrossRef