Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
5 "Diabetic vascular complication"
Filter
Filter
Article category
Keywords
Publication year
Authors
Reviews
Reactive Oxygen and Nitrogen Species in Pathogenesis of Vascular Complications of Diabetes
Seok Man Son
Diabetes Metab J. 2012;36(3):190-198.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.190
  • 5,415 View
  • 57 Download
  • 83 Crossref
AbstractAbstract PDFPubReader   

Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in subjects with diabetes. Disorders of the physiological signaling functions of reactive oxygen species (superoxide and hydrogen peroxide) and reactive nitrogen species (nitric oxide and peroxynitrite) are important features of diabetes. In the absence of an appropriate compensation by the endogenous antioxidant defense network, increased oxidative stress leads to the activation of stress-sensitive intracellular signaling pathways and the formation of gene products that cause cellular damage and contribute to the vascular complications of diabetes. It has recently been suggested that diabetic subjects with vascular complications may have a defective cellular antioxidant response against the oxidative stress generated by hyperglycemia. This raises the concept that antioxidant therapy may be of great benefit to these subjects. Although our understanding of how hyperglycemia-induced oxidative stress ultimately leads to tissue damage has advanced considerably in recent years, effective therapeutic strategies to prevent or delay the development of this damage remain limited. Thus, further investigation of therapeutic interventions to prevent or delay the progression of diabetic vascular complications is needed.

Citations

Citations to this article as recorded by  
  • Relationship of phytochemicals and antioxidant activities in Gymnema inodorum leaf extracts
    Onanong Nuchuchua, Wanwisa Srinuanchai, Chaisak Chansriniyom, Uthaiwan Suttisansanee, Piya Temviriyanukul, Nitra Nuengchamnong, Uracha Ruktanonchai
    Heliyon.2024; 10(1): e23175.     CrossRef
  • The Role of Glutathione and Its Precursors in Type 2 Diabetes
    Dawn Tuell, George Ford, Evan Los, William Stone
    Antioxidants.2024; 13(2): 184.     CrossRef
  • Combined toxicity of microplastics and copper on Goniopora columns
    Ya-Ting Chen, De-Sing Ding, Yee Cheng Lim, Cheng-Di Dong, Shu-Ling Hsieh
    Environmental Pollution.2024; 345: 123515.     CrossRef
  • Catalytic Nanoparticles in Biomedical Applications: Exploiting Advanced Nanozymes for Therapeutics and Diagnostics
    Divinah Manoharan, Liu‐Chun Wang, Ying‐Chi Chen, Wei‐Peng Li, Chen‐Sheng Yeh
    Advanced Healthcare Materials.2024;[Epub]     CrossRef
  • Oxidative Stress, Endothelial Dysfunction, and N-Acetylcysteine in Type 2 Diabetes Mellitus
    Xin Li, Junyong Zou, Aiping Lin, Jingshu Chi, Hong Hao, Hong Chen, Zhenguo Liu
    Antioxidants & Redox Signaling.2024;[Epub]     CrossRef
  • Acacia gum: Chemistry, properties & food applications
    Deepak Mudgil, Sheweta Mudgil
    Food and Humanity.2024; 2: 100264.     CrossRef
  • High glucose-induced increasing reactive nitrogen species accumulation triggered mitochondrial dysfunction, inflammation, and apoptosis in keratinocytes
    Huma Rizwan, Sonu Kumar, Golden Kumari, Arttatrana Pal
    Life Sciences.2023; 312: 121208.     CrossRef
  • Vitamin D–vitamin D receptor alleviates oxidative stress in ischemic acute kidney injury via upregulating glutathione peroxidase 3
    Xueqin Wu, Shiqi Tang, Qing Dai, Bin Yi, Shikun Yang, Jian Sun, Yong Zhong, Wei Lin, Jun Liu, Yan Liu, Jianwen Wang, Jishi Liu, Qin Liao, Wei Zhang, Hao Zhang
    The FASEB Journal.2023;[Epub]     CrossRef
  • Characterization, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities of green synthesized silver nanoparticles using Phragmanthera austroarabica A. G. Mill and J. A. Nyberg extract
    Dina M. Khodeer, Ali M. Nasr, Shady A. Swidan, Sarah Shabayek, Roaa M. Khinkar, Mohammed M. Aldurdunji, Maryam A. Ramadan, Jihan M. Badr
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • Toxic Effects of Copper Sulfate and Trichlorfon on the Intestines of Zebrafish (Danio rerio)
    Qing Li, Yangyang Cao, Yuting Wang, Xiaodong Long, Wenbo Sun, Hui Yang, Yingying Zhang, Zhitao Qi
    Aquaculture Research.2023; 2023: 1.     CrossRef
  • Early Detection Is the Best Prevention—Characterization of Oxidative Stress in Diabetes Mellitus and Its Consequences on the Cardiovascular System
    Sanela Rajlic, Hendrik Treede, Thomas Münzel, Andreas Daiber, Georg Daniel Duerr
    Cells.2023; 12(4): 583.     CrossRef
  • In vitroand computational studies of the antioxidant and anti-diabetic properties ofBridelia ferruginea
    Olajumoke Oyebode, Ochuko Lucky Erukainure, Lindiwe Zuma, Collins U. Ibeji, Neil Anthony Koorbanally, Md. Shahidul Islam
    Journal of Biomolecular Structure and Dynamics.2022; 40(9): 3989.     CrossRef
  • Oxidative distress in aging and age-related diseases: Spatiotemporal dysregulation of protein oxidation and degradation
    Sergey Zavadskiy, Susanna Sologova, Nurbubu Moldogazieva
    Biochimie.2022; 195: 114.     CrossRef
  • Effects of Smoking on Diabetic Nephropathy
    Yasemin Gündoğdu, İnan Anaforoğlu
    Frontiers in Clinical Diabetes and Healthcare.2022;[Epub]     CrossRef
  • Endogenous Protective Factors and Potential Therapeutic Agents for Diabetes-Associated Atherosclerosis
    Chaoqun Wang, Jin Chen, Pin Wang, Shengli Qing, Wenwen Li, Jin Lu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Antihyperglycemic activity of verbenone and L-arginine in nicotinamide-streptozotocin-induced diabetic mice: in vitro and in vivo studies
    Habibu Tijjani, Abdulkadir Mohammed Danyaro, Ahmed Olatunde, Aminu Umar Kura
    Beni-Suef University Journal of Basic and Applied Sciences.2022;[Epub]     CrossRef
  • Comparison of the combined toxicity of polystyrene microplastics and different concentrations of cadmium in zebrafish
    Hui Yang, Zhu Zhu, Yuexuan Xie, Chen Zheng, Zhenyuan Zhou, Tianhao Zhu, Yingying Zhang
    Aquatic Toxicology.2022; 250: 106259.     CrossRef
  • “EVALUATION OF HYPERGLYCEMIA INDUCED OXIDATIVE STRESS IN TYPE-2 DIABETIC PATIENT”
    Ameerul Hasan Amir, Faisal Iqubal, Savita Rathor, Afreena Nasir
    INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2022; : 12.     CrossRef
  • Evaluation of Anti-Hyperglycemia and Complications of Red and Black Thai Jasmine Rice Cultivars in Streptozotocin-Induced Diabetic Rats
    Nittiya Suwannasom, Chutamas Thepmalee, Krissana Khoothiam, Chonthida Thephinlap
    Molecules.2022; 27(22): 8043.     CrossRef
  • p38 MAPK Inhibitor (SB203580) and Metformin Reduces Aortic Protein Carbonyl and Inflammation in Non-obese Type 2 Diabetic Rats
    Nuttikarn Nokkaew, Podsawee Mongkolpathumrat, Ruttanapong Junsiri, Supawit Jindaluang, Nichagron Tualamun, Niya Manphatthanakan, Nareumon Saleesee, Marisa Intasang, Jantira Sanit, Punyanuch Adulyaritthikul, Kantapich Kongpol, Sarawut Kumphune, Nitirut Ner
    Indian Journal of Clinical Biochemistry.2021; 36(2): 228.     CrossRef
  • Elucidation of phytochemicals and antioxidants properties of Sasa quelpaertensis
    Hee Chul Ko, Mi Gyeong Jang, Jae-Won Kim, Songyee Baek, Nam Ho Lee, Se-Jae Kim
    International Journal of Food Properties.2021; 24(1): 210.     CrossRef
  • Organelle dynamics of endothelial mitochondria in diabetic angiopathy
    Hong Xiang, Ruipeng Song, Jie Ouyang, Ruifang Zhu, Zhihao Shu, Yulan Liu, Xuewen Wang, Dongtao Zhang, Jiangwei Zhao, Hongwei Lu
    European Journal of Pharmacology.2021; 895: 173865.     CrossRef
  • Hypoglycemic and antioxidant effects of green tomato ( Physalis ixocarpa Brot.) calyxes’ extracts
    Fernando Guerrero‐Romero, Luis E. Simental‐Mendía, María Inés Guerra Rosas, Víctor Iván Sayago‐Monreal, Juliana Morales Castro, Claudia I. Gamboa‐Gómez
    Journal of Food Biochemistry.2021;[Epub]     CrossRef
  • Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide-induced anaemia in rats
    Jamila Abdulhamid Atata, Taiwo Oluwaseun Ayoola, Abdullateef Abiodun Ajadi, Sani Adamu, Aishat O. Olatunji, Khalid Talha Biobaku
    Journal of Complementary and Integrative Medicine.2021; 18(1): 87.     CrossRef
  • NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes
    Ilona M. Gora, Anna Ciechanowska, Piotr Ladyzynski
    Cells.2021; 10(2): 314.     CrossRef
  • Potential Roles of Endoplasmic Reticulum Stress and Cellular Proteins Implicated in Diabesity
    Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Ismaeel Yunusa, Aishatu Shehu, Lukman Mustapha, Yusuf Wada, Mubarak Hussaini Ahmad, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Siti Safiah Mokhtar, Silvana Hrelia
    Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
  • Inflammation and apoptosis, two key events induced by hyperglycemia mediated reactive nitrogen species in RGC-5 cells
    Sweta Pal, G. Nageswar Rao, Arttatrana Pal
    Life Sciences.2021; 279: 119693.     CrossRef
  • The Predictive Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Levels of Diabetic Peripheral Neuropathy
    Meiqiao Chen, Yuyou Zhu, Jumei Wang, Guoping Wang, Yuanbo Wu
    Journal of Pain Research.2021; Volume 14: 2049.     CrossRef
  • The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasomes in the Development of Atherosclerosis
    V. V. Pushkarev, L. K. Sokolova, O. I. Kovzun, V. M. Pushkarev, M. D. Tronko
    Cytology and Genetics.2021; 55(4): 331.     CrossRef
  • Aging under Pressure: The Roles of Reactive Oxygen and Nitrogen Species (RONS) Production and Aging Skeletal Muscle in Endothelial Function and Hypertension—From Biological Processes to Potential Interventions
    Hollie Speer, Andrew J. McKune
    Antioxidants.2021; 10(8): 1247.     CrossRef
  • Natural Antioxidants in New Age-Related Diseases
    Arti Devi, Vagish Dwibedi, Zaved Ahmed Khan
    Revista Brasileira de Farmacognosia.2021; 31(4): 387.     CrossRef
  • Potential risks of endoplasmic reticulum stress on vasculopathy in diabetes
    Sagir Mustapha, Mustapha Mohammed, Ismaeel Yunusa, Aida Hanum Ghulam Rasool, Siti Safiah Mokhtar
    Obesity Medicine.2020; 19: 100274.     CrossRef
  • Potential roles of Citrulline and watermelon extract on metabolic and inflammatory variables in diabetes mellitus, current evidence and future directions: A systematic review
    Samaneh Azizi, Reza Mahdavi, Elnaz Vaghef‐Mehrabany, Vahid Maleki, Nahid Karamzad, Mehrangiz Ebrahimi‐Mameghani
    Clinical and Experimental Pharmacology and Physiology.2020; 47(2): 187.     CrossRef
  • Enzymic polypeptide antioxidant activity and inhibitory activity on α-glucosidase and α-amylase from Paeonia ostii cake
    Huiru Qiao, Xiaojuan Bi, Yuanyuan Zhang, Mengran Liu, Shuchong Zu, Nan Jia, Shougang Jiang, Qi Lu, Yuangang Zu, Yihong Bao
    Industrial Crops and Products.2020; 146: 112158.     CrossRef
  • Hypoglycemic and antioxidant properties of konjac ( Amorphophallus konjac ) in vitro and in vivo
    Claudia I. Gamboa‐Gómez, Fernando Guerrero‐Romero, Miguel A. Sánchez‐Meraz, Luis E. Simental‐Mendía
    Journal of Food Biochemistry.2020;[Epub]     CrossRef
  • Heme on Pulmonary Malaria: Friend or Foe?
    Tatiana Almeida Pádua, Mariana Conceição Souza
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases
    Thomas CW. Chan, Jennifer L. Wilkinson Berka, Devy Deliyanti, Damien Hunter, Adrian Fung, Gerald Liew, Andrew White
    Experimental Eye Research.2020; 201: 108255.     CrossRef
  • The Effect of an Atherogenic Diet and Acute Hyperglycaemia on Endothelial Function in Rabbits Is Artery Specific
    Alexander Tacey, Tawar Qaradakhi, Cassandra Smith, Chris Pittappillil, Alan Hayes, Anthony Zulli, Itamar Levinger
    Nutrients.2020; 12(7): 2108.     CrossRef
  • Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway
    Xiaoliang Dong, Di Wu, Yihan Zhang, Lingling Jia, Xiaohua Pan, Jia Sun, Li-Long Pan
    Antioxidants.2020; 9(6): 491.     CrossRef
  • Immune-Inflammation in Atherosclerosis: A New Twist in an Old Tale
    Atefe Ghamar Talepoor, Hamed Fouladseresht, Shahdad Khosropanah, Mehrnoosh Doroudchi
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(4): 525.     CrossRef
  • Fabrication of sensitive D-fructose sensor based on facile ternary mixed ZnO/CdO/SnO2 nanocomposites by electrochemical approach
    M.M. Alam, Abdullah M. Asiri, Mohammed M. Rahman, M.A. Islam
    Surfaces and Interfaces.2020; 19: 100540.     CrossRef
  • The role of glutathione and glutathione peroxidase in regulating cellular level of reactive oxygen and nitrogen species
    Sheetal Panday, Raghav Talreja, Mahendra Kavdia
    Microvascular Research.2020; 131: 104010.     CrossRef
  • Evaluation of the Antioxidant and Antidiabetic Potential of the Poly Herbal Formulation: Identification of Bioactive Factors
    V.V. Sathibabu Uddandrao, Parim Brahmanaidu, Saravanan Ganapathy
    Cardiovascular & Hematological Agents in Medicinal Chemistry.2020; 18(2): 111.     CrossRef
  • Rule of UA on Cardiac Myocytes Uric Acid Differently Influence the Oxidative Damage Induced by Acute Exposure of High Level of Glucose in Chicken Cardiac Myocytes
    Xiaolong Sun, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Hai Lin
    Frontiers in Veterinary Science.2020;[Epub]     CrossRef
  • Elevated Serum Levels of Ischemia Modified Albumin and Malondialdehyde are Related to Atherogenic Index of Plasma in a Cohort of Prediabetes
    Mervat M. El-Eshmawy, Doaa F. Gad, Azza A. El-Baiomy
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(8): 1347.     CrossRef
  • Low serum bilirubin levels contribute to the presence and progression of distal symmetrical polyneuropathy in Chinese patients with type 2 diabetes
    J. Jin, W. Wang, T. Gu, C. Chen, J. Sun, W. Chen, Y. Bi, D. Zhu
    Diabetes & Metabolism.2019; 45(1): 47.     CrossRef
  • Therapeutic Benefit of Dillenia indica in Diabetes and Its Associated Complications
    Parul Kamboj, Narayan C. Talukdar, Sanjay K. Banerjee
    Journal of Diabetes Research.2019; 2019: 1.     CrossRef
  • The impact of xanthine oxidase (XO) on hemolytic diseases
    Heidi M. Schmidt, Eric E. Kelley, Adam C. Straub
    Redox Biology.2019; 21: 101072.     CrossRef
  • What is responsible for antioxidant properties of polyphenolic compounds from plants?
    Małgorzata Olszowy
    Plant Physiology and Biochemistry.2019; 144: 135.     CrossRef
  • Leucocyte Telomere Length and Glucose Tolerance Status in Mixed-Ancestry South Africans
    Cecil J. Weale, Glenda M. Davison, Gloudina M. Hon, Andre P. Kengne, Rajiv T. Erasmus, Tandi E. Matsha
    Cells.2019; 8(5): 464.     CrossRef
  • Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress
    Xiaojuan Yang, Jing Song, Liang-Jun Yan
    Antioxidants.2019; 8(2): 32.     CrossRef
  • Cilostazol Attenuates Retinal Oxidative Stress and Inflammation in a Streptozotocin-Induced Diabetic Animal Model
    Po-Ting Yeh, Yu-Hsun Huang, Shu-Wen Chang, Lu-Chun Wang, Chung-May Yang, Wei-Shiung Yang, Chung-Wu Lin, Chang-Hao Yang
    Current Eye Research.2019; 44(3): 294.     CrossRef
  • Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1
    Hatem Maamoun, Tarek Benameur, Gianfranco Pintus, Shankar Munusamy, Abdelali Agouni
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • Novel Curcumin C66 That Protects Diabetes-Induced Aortic Damage Was Associated with Suppressing JNK2 and Upregulating Nrf2 Expression and Function
    Cheng Li, Xiao Miao, Shudong Wang, Binay Kumar Adhikari, Xin Wang, Jian Sun, Quan Liu, Qian Tong, Yonggang Wang
    Oxidative Medicine and Cellular Longevity.2018; 2018: 1.     CrossRef
  • Nebivolol, a β-blocker abrogates streptozotocin-induced behavioral, biochemical, and neurophysiological deficit by attenuating oxidative-nitrosative stress: a possible target for the prevention of diabetic neuropathy
    Naini Bhadri, Rema Razdan, Sumanta Kumar Goswami
    Naunyn-Schmiedeberg's Archives of Pharmacology.2018; 391(2): 207.     CrossRef
  • Angiogenic Dysregulation in Pregnancy-Related Hypertension—A Role for Metformin
    Nerolen Soobryan, Saravanakumar Murugesan, Arunagiri Pandiyan, Jagidesa Moodley, Irene Mackraj
    Reproductive Sciences.2018; 25(11): 1531.     CrossRef
  • Nutrients and Oxidative Stress: Friend or Foe?
    Bee Ling Tan, Mohd Esa Norhaizan, Winnie-Pui-Pui Liew
    Oxidative Medicine and Cellular Longevity.2018; 2018: 1.     CrossRef
  • Free radical scavenging, α-glucosidase inhibitory and lipase inhibitory activities of eighteen Sudanese medicinal plants
    Sara Mustafa Idris Elbashir, Hari Prasad Devkota, Mikiyo Wada, Naoki Kishimoto, Masataka Moriuchi, Tsuyoshi Shuto, Shogo Misumi, Hirofumi Kai, Takashi Watanabe
    BMC Complementary and Alternative Medicine.2018;[Epub]     CrossRef
  • An Update on Hypertension in Children With Type 1 Diabetes
    Mallory L. Downie, Emma H. Ulrich, Damien G. Noone
    Canadian Journal of Diabetes.2018; 42(2): 199.     CrossRef
  • Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling
    Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie L. Conley, Thiagarajan Sairam, Ashutosh Kumar, Ronald P. Mason, Ramalingam Sankaran, John R. Hoidal, Namakkal S. Rajasekaran
    Frontiers in Physiology.2017;[Epub]     CrossRef
  • Protective effects of 6-Gingerol on vascular endothelial cell injury induced by high glucose via activation of PI3K-AKT-eNOS pathway in human umbilical vein endothelial cells
    Dan Liu, Mengqing Wu, Yi Lu, Tao Xian, Yupeng Wang, Bowei Huang, Guohua Zeng, Qiren Huang
    Biomedicine & Pharmacotherapy.2017; 93: 788.     CrossRef
  • Evaluation of the release profile, stability and antioxidant activity of a proanthocyanidin-rich cinnamon (Cinnamomum zeylanicum) extract co-encapsulated with α-tocopherol by spray chilling
    Fabrício L. Tulini, Volnei B. Souza, Marcelo Thomazini, Marluci P. Silva, Adna P. Massarioli, Severino M. Alencar, Eliria M.J.A. Pallone, Maria I. Genovese, Carmen S. Favaro-Trindade
    Food Research International.2017; 95: 117.     CrossRef
  • Modulatory Effect of Achyranthes aspera L., Seeds on Carbohydrates and Protein Bound Enzymes on High Fructose Fed Diet
    Veerappan Ramanathan, Malarvili Thekkumala
    Journal of Pharmacology and Toxicology.2017; 12(3): 154.     CrossRef
  • Pyrethroid insecticide lambda-cyhalothrin and its metabolites induce liver injury through the activation of oxidative stress and proinflammatory gene expression in rats following acute and subchronic exposure
    Bakhta Aouey, Mohamed Derbali, Yassine Chtourou, Michèle Bouchard, Abdelmajid Khabir, Hamadi Fetoui
    Environmental Science and Pollution Research.2017; 24(6): 5841.     CrossRef
  • Effect of hydroxychloroquine on oxidative/nitrosative status and angiogenesis in endothelial cells under high glucose condition
    Aysa Rezabakhsh, Soheila Montazersaheb, Elahe Nabat, Mehdi Hassanpour, Azadeh Montaseri, Hassan Malekinejad, Ali Akbar Movassaghpour, Reza Rahbarghazi, Alireza Garjani
    BioImpacts.2017; 7(4): 219.     CrossRef
  • The Effect of Vitamin E on Oxidative Stress Indicated by Serum Malondialdehyde in Insulin-dependent Type 2 Diabetes Mellitus Patients with Retinopathy
    Irini P. Chatziralli, George Theodossiadis, Prodromos Dimitriadis, Michail Charalambidis, Antonios Agorastos, Zisis Migkos, Nikolaos Platogiannis, Marilita M. Moschos, Panagiotis Theodossiadis, Petros Keryttopoulos
    The Open Ophthalmology Journal.2017; 11(1): 51.     CrossRef
  • Association between Fluorescent Advanced Glycation End-Products and Vascular Complications in Type 2 Diabetic Patients
    Alexis Guerin-Dubourg, Maxime Cournot, Cynthia Planesse, Xavier Debussche, Olivier Meilhac, Philippe Rondeau, Emmanuel Bourdon
    BioMed Research International.2017; 2017: 1.     CrossRef
  • Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity
    Xiaoting Luo, Jinzi Wu, Siqun Jing, Liang-Jun Yan
    Aging and disease.2016; 7(1): 90.     CrossRef
  • İNSAN VE HAYVANLARDA DİABETES MELLİTUS
    Özlem ÖZMEN, Senay TOPSAKAL
    Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi.2016; 1(1): 47.     CrossRef
  • The novel mitochondria-targeted hydrogen sulfide (H 2 S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro
    Domokos Gerő, Roberta Torregrossa, Alexis Perry, Alicia Waters, Sophie Le-Trionnaire, Jacqueline L. Whatmore, Mark Wood, Matthew Whiteman
    Pharmacological Research.2016; 113: 186.     CrossRef
  • Heated apple juice supplemented with onion has greatly improved nutritional quality and browning index
    Bonggi Lee, Jeong Dae Seo, Jin-Kyu Rhee, Choon Young Kim
    Food Chemistry.2016; 201: 315.     CrossRef
  • Inverse association between serum total bilirubin levels and diabetic peripheral neuropathy in patients with type 2 diabetes
    Eun Sook Kim, Sung Won Lee, Eun Young Mo, Sung Dae Moon, Je Ho Han
    Endocrine.2015; 50(2): 405.     CrossRef
  • Interactions of short-acting, intermediate-acting and pre-mixed human insulins with free radicals—Comparative EPR examination
    Paweł Olczyk, Katarzyna Komosinska-Vassev, Paweł Ramos, Łukasz Mencner, Krystyna Olczyk, Barbara Pilawa
    International Journal of Pharmaceutics.2015; 490(1-2): 9.     CrossRef
  • Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells
    L. F. Heinrich, D. K. Andersen, M. E. Cleasby, C. Lawson
    British Journal of Nutrition.2015; 113(11): 1704.     CrossRef
  • Gum Arabic extracts protect against hepatic oxidative stress in alloxan induced diabetes in rats
    Abdelkareem A. Ahmed, Jaafar S. Fedail, Hassan H. Musa, Asghar Ali Kamboh, Amal Z. Sifaldin, Taha H. Musa
    Pathophysiology.2015; 22(4): 189.     CrossRef
  • Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits
    J Roganović, LJ Djukić, E Kršljak, N Tanić, D Stojić
    Oral Diseases.2015; 21(5): 634.     CrossRef
  • Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relevance in Diabetic Retinopathy
    Michael Anthony Ruiz, Biao Feng, Subrata Chakrabarti, Rong Wen
    PLOS ONE.2015; 10(4): e0123987.     CrossRef
  • Anti-hyperglycaemic effect ofPhragmenthera austroarabicaA.G.Mill. & J.A.Nyberg extract in streptozotocin-induced diabetes in rats
    Abeer Hanafy, Jihan M. Badr
    Natural Product Research.2014; 28(24): 2351.     CrossRef
  • Functional and morphological changes of the diencephalon vascular endothelium of rats in experimental ischemia-reperfusion injury and diabetes mellitus
    TM Boĭchuk, TP Savchuk
    Fiziolohichnyĭ zhurnal.2014; 59(6): 30.     CrossRef
  • Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox
    Paulo Zoé Costa, Raquel Soares
    Life Sciences.2013; 92(22): 1037.     CrossRef
  • Oxidative-stress-induced epigenetic changes in chronic diabetic complications
    Biao Feng, Michael Anthony Ruiz, Subrata Chakrabarti
    Canadian Journal of Physiology and Pharmacology.2013; 91(3): 213.     CrossRef
  • Effect of α-Linolenic Acid on Streptozotocin-induced Diabetic Retinopathy Indices In Vivo
    Jun-hui Shen, Qi Ma, Shen-grong Shen, Guo-Tong Xu, Undurti N. Das
    Archives of Medical Research.2013; 44(7): 514.     CrossRef
  • Antihyperglycemic Effect ofGinkgo bilobaExtract in Streptozotocin-Induced Diabetes in Rats
    Daye Cheng, Bin Liang, Yunhui Li
    BioMed Research International.2013; 2013: 1.     CrossRef
New Perspectives on Diabetic Vascular Complications: The Loss of Endogenous Protective Factors Induced by Hyperglycemia
In-Kyung Jeong, George L. King
Diabetes Metab J. 2011;35(1):8-11.   Published online February 28, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.1.8
  • 6,404 View
  • 35 Download
  • 24 Crossref
AbstractAbstract PDFPubReader   

Diabetic vascular complications are among the leading causes of morbidity and mortality in diabetic patients. In the past, many studies have focused on the mechanisms of hyperglycemia-induced chronic vascular complications via the formation of toxic metabolites such as oxidative stress, advanced glycosylated end products, persistent activation of protein kinase C, and increased sorbitol concentrations. However, vascular complications result from imbalances caused by increases in systemic toxic metabolites, such as those that occur under conditions of hyperglycemia and dyslipidemia, and by reductions in endogenous protective factors such as insulin, vascular endothelial growth factor, and platelet derived growth factor. This review outlines some of the evidence supporting the importance of enhancing endogenous regenerative factors.

Citations

Citations to this article as recorded by  
  • Role of platelet-derived growth factor c on endothelial dysfunction in cardiovascular diseases
    Adriana Grismaldo, Luis Sobrevia, Ludis Morales
    Biochimica et Biophysica Acta (BBA) - General Subjects.2022; 1866(10): 130188.     CrossRef
  • Ginkgo biloba extracts protect human retinal Müller glial cells from t-BHP induced oxidative damage by activating the AMPK-Nrf2-NQO-1 axis
    Yue Li, Ke Wang, Xue Zhu, Zhengqi Cheng, Ling Zhu, Michael Murray, Fanfan Zhou
    Journal of Pharmacy and Pharmacology.2022;[Epub]     CrossRef
  • Organic Isothiocyanates as Hydrogen Sulfide Donors
    Alma Martelli, Valentina Citi, Lara Testai, Simone Brogi, Vincenzo Calderone
    Antioxidants & Redox Signaling.2020; 32(2): 110.     CrossRef
  • PGC‐1α, a potential therapeutic target against kidney aging
    Gayoung Lee, Md Jamal Uddin, Yoojeong Kim, Minji Ko, Inyoung Yu, Hunjoo Ha
    Aging Cell.2019;[Epub]     CrossRef
  • Glucometabolic characteristics and higher vascular complication risk in Korean patients with type 2 diabetes with non-albumin proteinuria
    Yongin Cho, Yong-ho Lee, Eun Seok Kang, Bong-soo Cha, Byung-wan Lee
    Journal of Diabetes and its Complications.2019; 33(8): 585.     CrossRef
  • Ameliorative effects of taurine against diabetes: a review
    Inam-u-llah, Fengyuan Piao, Rana Muhammad Aadil, Raheel Suleman, Kaixin Li, Mengren Zhang, Pingan Wu, Muhammad Shahbaz, Zulfiqar Ahmed
    Amino Acids.2018; 50(5): 487.     CrossRef
  • Notoginsenoside Fc attenuates high glucose-induced vascular endothelial cell injury via upregulation of PPAR-γ in diabetic Sprague–Dawley rats
    Jingjing Liu, Chunyu Jiang, Xu Ma, Jianbo Wang
    Vascular Pharmacology.2018; 109: 27.     CrossRef
  • Grape seed proanthocyanidin extract protects the retina against early diabetic injury by activating the Nrf2 pathway
    YAN SUN, CAIMEI XIU, WEI LIU, YUAN TAO, JIANRONG WANG, YI QU
    Experimental and Therapeutic Medicine.2016; 11(4): 1253.     CrossRef
  • Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway
    Wensong Zhang, Yi Li, Hanlu Ding, Yaqin Du, Li Wang
    Renal Failure.2016; 38(7): 1099.     CrossRef
  • TNFSF15 Inhibits Blood Retinal Barrier Breakdown Induced by Diabetes
    Feng Jiang, Qingzhong Chen, Liming Huang, Ying Wang, Zhuhong Zhang, Xiangda Meng, Yuanyuan Liu, Chunjie Mao, Fang Zheng, Jingkai Zhang, Hua Yan
    International Journal of Molecular Sciences.2016; 17(5): 615.     CrossRef
  • Effect of Triflusal on Primary Vascular Dysregulation Compared with Aspirin: A Double-Blind, Randomized, Crossover Trial
    Sanghoon Shin, Kwang-Joon Kim, In-Jeong Cho, Geu-Ru Hong, Yangsoo Jang, Namsik Chung, Young Min Rah, Hyuk-Jae Chang
    Yonsei Medical Journal.2015; 56(5): 1227.     CrossRef
  • NRF2 plays a protective role in diabetic retinopathy in mice
    Zhenhua Xu, Yanhong Wei, Junsong Gong, Hongkwan Cho, James K. Park, Ee-Rah Sung, Hu Huang, Lijuan Wu, Charles Eberhart, James T. Handa, Yunpeng Du, Timothy S. Kern, Rajesh Thimmulappa, Alistair J. Barber, Shyam Biswal, Elia J. Duh
    Diabetologia.2014; 57(1): 204.     CrossRef
  • Inhibition of JNK by compound C66 prevents pathological changes of the aorta in STZ‐induced diabetes
    Yucheng Liu, Yonggang Wang, Xiao Miao, Shanshan Zhou, Yi Tan, Guang Liang, Yang Zheng, Quan Liu, Jian Sun, Lu Cai
    Journal of Cellular and Molecular Medicine.2014; 18(6): 1203.     CrossRef
  • Sulforaphane Attenuation of Type 2 Diabetes-Induced Aortic Damage Was Associated with the Upregulation of Nrf2 Expression and Function
    Yonggang Wang, Zhiguo Zhang, Wanqing Sun, Yi Tan, Yucheng Liu, Yang Zheng, Quan Liu, Lu Cai, Jian Sun
    Oxidative Medicine and Cellular Longevity.2014; 2014: 1.     CrossRef
  • Therapeutic Effect of MG132 on the Aortic Oxidative Damage and Inflammatory Response in OVE26 Type 1 Diabetic Mice
    Xiao Miao, Wenpeng Cui, Weixia Sun, Ying Xin, Bo Wang, Yi Tan, Lu Cai, Lining Miao, Yaowen Fu, Guanfang Su, Yuehui Wang
    Oxidative Medicine and Cellular Longevity.2013; 2013: 1.     CrossRef
  • Risk Factors for the Progression of Intima-Media Thickness of Carotid Arteries: A 2-Year Follow-Up Study in Patients with Newly Diagnosed Type 2 Diabetes
    Sang Ouk Chin, Jin Kyung Hwang, Sang Youl Rhee, Suk Chon, You-Cheol Hwang, Seungjoon Oh, Kyu Jeung Ahn, Ho Yeon Chung, Jeong-taek Woo, Sung-Woon Kim, Young Seol Kim, Ja-Heon Kang, In-Kyung Jeong
    Diabetes & Metabolism Journal.2013; 37(5): 365.     CrossRef
  • Downregulation of Nrf2 and HO-1 expression contributes to oxidative stress in type 2 diabetes mellitus: A study in Juana Koslay City, San Luis, Argentina
    Susana Siewert, Irma González, Lucas Santillán, Roberto Lucero, Marta S. Ojeda, María S. Gimenez
    Journal of Diabetes Mellitus.2013; 03(02): 71.     CrossRef
  • The effect of oral prostaglandin analogue on painful diabetic neuropathy: a double‐blind, randomized, controlled trial
    S. Shin, K. J. Kim, H. ‐J. Chang, B. ‐W. Lee, W. ‐I. Yang, B. ‐S. Cha, D. Choi
    Diabetes, Obesity and Metabolism.2013; 15(2): 185.     CrossRef
  • Areca nut procyanidins ameliorate streptozocin-induced hyperglycemia by regulating gluconeogenesis
    Pei-Ling Huang, Chin-Wen Chi, Tsung-Yun Liu
    Food and Chemical Toxicology.2013; 55: 137.     CrossRef
  • Serum glycated albumin predicts the progression of carotid arterial atherosclerosis
    Sun Ok Song, Kwang Joon Kim, Byung-Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee
    Atherosclerosis.2012; 225(2): 450.     CrossRef
  • Sulforaphane prevention of diabetes-induced aortic damage was associated with the up-regulation of Nrf2 and its down-stream antioxidants
    Xiao Miao, Yang Bai, Weixia Sun, Wenpeng Cui, Ying Xin, Yuehui Wang, Yi Tan, Lining Miao, Yaowen Fu, Guanfang Su, Lu Cai
    Nutrition & Metabolism.2012;[Epub]     CrossRef
  • Association between EPCs count and rate of coronary revascularization in asymptomatic type 2 diabetic patients
    Hyun Min Kim, Kwang Joon Kim, Jae Hoon Moon, Hye-Jeong Lee, Min Kyung Chae, Hyuk-Jae Chang, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Young Jin Kim, Byung-Wan Lee
    Acta Diabetologica.2012; 49(6): 413.     CrossRef
  • Taurine ameliorates hyperglycemia and dyslipidemia by reducing insulin resistance and leptin level in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term diabetes
    Kyoung Soo Kim, Da Hee Oh, Jung Yeon Kim, Bong Gn Lee, Jeong Soon You, Kyung Ja Chang, Hyunju Chung, Myung Chul Yoo, Hyung-In Yang, Ja-Heon Kang, Yoo Chul Hwang, Kue Jeong Ahn, Ho-Yeon Chung, In-Kyung Jeong
    Experimental & Molecular Medicine.2012; 44(11): 665.     CrossRef
  • Inhibition of NF-κB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells
    In-Kyung Jeong, Da Hee Oh, Seung-Joon Park, Ja-Heon Kang, Sunshin Kim, Myung-Shik Lee, Myung-Jun Kim, Yoo-Chul Hwang, Kyu Jeong Ahn, Ho-Yeon Chung, Min-Kyung Chae, Hyung-Joon Yoo
    Experimental and Molecular Medicine.2011; 43(12): 684.     CrossRef
Original Articles
High Glucose Modulates Vascular Smooth Muscle Cell Proliferation Through Activation of PKC-sigma-dependent NAD(P)H oxidase.
Bo Hyun Kim, Chang Won Lee, Jung Lae Park, Yang Ho Kang, In Ju Kim, Yong Ki Kim, Seok Man Son
Korean Diabetes J. 2006;30(6):416-427.   Published online November 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.6.416
  • 1,942 View
  • 18 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
Oxidative stress is thought to be one of the causative factors contributing to macrovascular complications in diabetes. However, the mechanisms of development and progression of diabetic vascular complications are poorly understood. We hypothesized that PKC-sigma isozyme contributes to ROS generation and determined their roles in the critical intermediary signaling events in high glucose-induced proliferation of vascular smooth muscle (VSM) cells. METHODS: We treated primary cultured rat aortic smooth muscle cells for 72 hours with medium containing 5.5 mmol/L D-glucose (normal glucose), 30 mmol/L D-glucose (high glucose) or 5.5 mmol/L D-glucose plus 24.5 mmol/L mannitol (osmotic control). We then measured cell number, BrdU incorporation, cell cycle and superoxide production in VSM cells. Immunoblotting of PKC isozymes using phoshospecific antibodies was performed, and PKC activity was also measured. RESULTS: High glucose increased VSM cell number and BrdU incorporation and displayed significantly greater percentages of S and G2/M phases than compared to 5.5 mmol/L glucose and osmotic control. The nitroblue tetrazolium (NBT) staining in high glucose-treated VSM cell was more prominent compared with normal glucose-treated VSM cell, which was significantly inhibited by DPI (10 micrometer), but not by inhibitors for other oxidases. High glucose also markedly increased activity of PKC-sigma isozyme. When VSM cells were treated with rottlerin, a specific inhibitor of PKC-sigma or transfected with PKC-sigma siRNA, NBT staining and NAD(P)H oxidase activity were significantly attenuated in the high glucose-treated VSM cells. Furthermore, inhibition of PKC-sigma markedly decreased VSM cell number by high glucose. CONCLUSION: These results suggest that high glucose-induced VSM cell proliferation is dependent upon activation of PKC-sigma, which may responsible for elevated intracellular ROS production in VSM cells, and this is mediated by NAD(P)H oxidase.

Citations

Citations to this article as recorded by  
  • High Glucose and/or Free Fatty Acid Damage Vascular Endothelial Cells via Stimulating of NAD(P)H Oxidase-induced Superoxide Production from Neutrophils
    Sang Soo Kim, Sun Young Kim, Soo Hyung Lee, Yang Ho Kang, In Ju Kim, Yong Ki Kim, Seok Man Son
    Korean Diabetes Journal.2009; 33(2): 94.     CrossRef
Study on Role of Neutrophil in Endothelial Cell Injury under High Glucose Condition.
Seok Man Son, In Ju Kim, Yong Ki Kim
Korean Diabetes J. 2000;24(6):652-665.   Published online January 1, 2001
  • 767 View
  • 17 Download
AbstractAbstract PDF
BACKGROUND
High glucose level plays a major role in the injury of endothelium during the early event in diabetic vascular complication. It was speculated that high glucose level may cause endothelial cell injury by neutrophil activation. METHODS: The human umbilical vein endothelial cells (HUVEC) were obtained from American Type Culture Collection. The cells were incubated as long as 24 hours to evaluate the expression of E-selectin on the cell surface using whole cell ELISA method. The adherence of neutrophils to human umbilical endothelial cell monolayers and transendothelial migration of 51Cr-labeled neutrophils were evaluated under the condition of different concentrations of D-glucose (5.5, 15, and 30 mmol/L). L-glucose (30 mmol/L) was used as an osmotic control after 24h incubation. We also measured neutrophil-mediated endothelial cell cytotoxicity using a 51Cr-release assay and release of activating markers (lactoferrin and myeloeroxidase) from neutrophils under the same conditions. RESULTS: The expression of E-selectin was increased on endothelium when incubated with medium containing high glucose (30 mmol/L) compared to control (5.5 mmol/L) preparation (1.36 OD vs. 0.79 OD, p<0.05). Increased adherence of neutrophils to HUVEC was observed with high glucose when compared to control (10.4% vs. 2.9%, p<0.01). Similarly, neutrophil migration across the cultured endothelial monolayers were also significantly increased by high glucose (49.8% vs. 27.3%, p<0.05). 51Cr-release from endothelial cells by neutrophils stimulated with high glucose was greater than that with control (27.5% vs. 10.6%, p<0.05). Release of activating markers from neutrophils incubated with high glucose was greater than that from neutrophils incubated with control. CONCLUSION: These results indicate that high glucose increases the adherence and transendothelial migration of neutrophils and cause endothelial cell injury through neutrophil activation. Thus, it is concluded that high glucose level maybe contribute to manifestation of the diabetic vascular disease, including the early step in the initiation of an acute inflammation of vascular endothelial cells.
Effect of high glucose on function of cultured rabbit vascular endothelial cells.
Seok Man Son, In Ju Kim, Yong Ki Kim, Chi Dae Kim, Ki Whan Hong
Korean Diabetes J. 1997;21(2):156-167.   Published online January 1, 2001
  • 905 View
  • 16 Download
AbstractAbstract PDF
BACKGROUND
Vascular disease accounts for the majority of the clinical complications of diabetes mellitus. Changes in local control of vascular tone such as imbalanced production of relaxing and contracting factors by endothelium may be related to the initiation and maintenance of abnormal vascular reactivity characteristically seen in diabetic vascular complications. Cytokines and growth factors released from injured endothelial cells, T-cells, and macro-phages enhance atherogenesis. In this study, we examined NO and TNF-a released from cultured rabbit aortic endothelial cells(RAECs) under different glucose concentration to investigate the relationship between high glucose and endothelial cell dysfunction. METHODS: The thoracic and abdominal aortae of rabbit(23kg) were isolated and periadventitial connective tissue was carefully removed. Rabbit aortic endothelial cells in primary culture were prepared by the m.ethod of Schwartz with modification. RAECs were grown to confluence in 25 cm2 flask in DMEM supplemented with 20% FBS, 150pg/mL endothelial cell growth supplernent, 90pg/mL heparin, 100 U/mL penicillin and 100pg/mL streptomycin at 37'C in humidified 5% carbon dioxide in air. For experiments, confluent cells were replaced in 1 1 mm, 48 well plate containing same medium composition. Cells were then incubated in the presence or absence of FBS for various times up to 48 hours(time course) to eveluate the NO and TNF-a response to different glucose concentrations(0, 5.5, 11, 22, and 44 mmol/ L). Cells were also incubated with various concentration of ACH and ADP(10, 10', 10 and 10' mol/L) and 10' mol/L of ACH or ADP with different glucose concentrations for 24 hours to evaluate stimulated effect of ACH and ADP on NO release. RESULTS: 1) Total NO release from RAECs was significantly in a time-dependent. After 48 hours incubation, the total secretion of NO was significantly higher in culture medium with FRS than without FBS. 2) Glucose concentration resembling severe hyper-glycemic conditions(22 and 44 mmol/L) significantly inhibited NO release from RAECs, 3) Acetylcholine and ADP induced a clear dose-dependent NO release in RAECs. 4) Stimulation of acetylcholine and ADP on NO release according to different glucose concentration was not significantly higher than NO release in culture medium with glucose alone. 5) The increment in TNF-a levels was associated with a significant increase at higher glucose concentration, 6) There was a negative correlation between NO and TNF-a release in culture medium with FBS but not in culture medium without FBS. CONCLUSION: Our data show that decreased NO release and increased TNF-a release from RAECs were noted under high glucose concentration. Such interaction could play a significant role in the development of diabetic vascular complication in hyperglycernic conditions.

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer