KDA
- Current
- Browse
- Collections
-
For contributors
- For Authors
- Instructions for authors
- Article processing charge
- For Reviewers
- Instructions for reviewers
- How to become a reviewer
- Best reviewers
- For Readers
- Readership
- Subscription
- Permission guidelines
- About
- Editorial policy
Search
- Page Path
- HOME > Search
Review
- Pathophysiology
- Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes
- Da Young Lee, Inha Jung, So Young Park, Ji Hee Yu, Ji A Seo, Kyeong Jin Kim, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Nan Hee Kim
- Diabetes Metab J. 2024;48(1):37-52. Published online January 3, 2024
- DOI: https://doi.org/10.4093/dmj.2023.0193
- 26,255 View
- 707 Download
- 14 Web of Science
- 14 Crossref
-
Abstract
PDF
PubReader 
ePub - Novel strategies are required to reduce the risk of developing diabetes and/or clinical outcomes and complications of diabetes. In this regard, the role of the circadian system may be a potential candidate for the prevention of diabetes. We reviewed evidence from animal, clinical, and epidemiological studies linking the circadian system to various aspects of the pathophysiology and clinical outcomes of diabetes. The circadian clock governs genetic, metabolic, hormonal, and behavioral signals in anticipation of cyclic 24-hour events through interactions between a “central clock” in the suprachiasmatic nucleus and “peripheral clocks” in the whole body. Currently, circadian rhythmicity in humans can be subjectively or objectively assessed by measuring melatonin and glucocorticoid levels, core body temperature, peripheral blood, oral mucosa, hair follicles, rest-activity cycles, sleep diaries, and circadian chronotypes. In this review, we summarized various circadian misalignments, such as altered light-dark, sleep-wake, rest-activity, fasting-feeding, shift work, evening chronotype, and social jetlag, as well as mutations in clock genes that could contribute to the development of diabetes and poor glycemic status in patients with diabetes. Targeting critical components of the circadian system could deliver potential candidates for the treatment and prevention of type 2 diabetes mellitus in the future.
-
Citations
Citations to this article as recorded by
- Late-eating adolescents consume more energy, make poorer dietary choices, and are more likely to have excess weight: An analysis of the Brazilian Household Budget Survey (2008–2009)
Maria Carliana Mota, Laura Cristina Tibiletti Balieiro, Luana Thomazetto Rossato, Claudia Roberta de Castro Moreno, Cibele Aparecida Crispim
Chronobiology International.2026; 43(1): 104. CrossRef - Unraveling the Tapestry of Health: The Intricate Dance of Circadian Rhythms and Human Diseases
Sidrah Parvez, Andrej Dzupina, Ghizal Fatima, Najah Hadi, Jan Fedacko, Aminat Magomedova, Ammar Mehdi Raza, Nasser Ghaly Yousif, Hekmat B. Alhmadi
Bratislava Medical Journal.2026; 127(2): 492. CrossRef - Diabetes and its complications: molecular mechanisms, prevention and treatment
Lijun Zhao, Jiamin Yuan, Qing Yang, Jing Ma, Fenghao Yang, Yutong Zou, Ke Liu, Fang Liu
Signal Transduction and Targeted Therapy.2026;[Epub] CrossRef - Prediabetes is a window of opportunity for preventive interventions. Part 2
T. V. Adasheva, E. E. Gubernatorova, E. I. Fomina, E. G. Lobanova
Meditsinskiy sovet = Medical Council.2026; (23): 123. CrossRef - Association of daytime circadian-aligned activity with glycemic control in type 2 diabetes: Insights from continuous glucose monitoring and wearable data
Da Young Lee, Jung-Been Lee, Inha Jung, So Young Park, Ji Hee Yu, Ji A Seo, Heon-Jeong Lee, Nan Hee Kim
Metabolism.2026; 179: 156570. CrossRef - Applying AI Tools for Monitoring Nutrition and Physical Activity in Populations with Obesity: Are We Ready?
Alessandra Amato, Sara Baldassano, Giuseppe Musumeci
Obesities.2026; 6(2): 19. CrossRef - PERSONALIZED CHRONOTHERAPY: BRIDGING PRECISION MEDICINE WITH CIRCADIAN THERAPEUTICS
Rajeswari Aleti, Monika Nijhawan, Mohammad Bakhatwar, Srinivas Baratam, Krishna Kishore Adireddy
INDIAN DRUGS.2026; 63(03): 8. CrossRef - Chrononutrition: Potential, Challenges, and Application in Managing Obesity
Siti Aisyah Fuad, Rehna Paula Ginting, Min-Woo Lee
International Journal of Molecular Sciences.2025; 26(11): 5116. CrossRef - Chrononutrition and Energy Balance: How Meal Timing and Circadian Rhythms Shape Weight Regulation and Metabolic Health
Claudia Reytor-González, Daniel Simancas-Racines, Náthaly Mercedes Román-Galeano, Giuseppe Annunziata, Martina Galasso, Raynier Zambrano-Villacres, Ludovica Verde, Giovanna Muscogiuri, Evelyn Frias-Toral, Luigi Barrea
Nutrients.2025; 17(13): 2135. CrossRef - Chronic stress, gut microbiota, and immunity: interconnections and implications for health
Hexiao Jia, Xiaodong Guo, Yihong Wei, Can Can, Na He, Hailei Zhang, Xinyu Yang, Hanyang Wu, Wancheng Liu, Daoxin Ma
Molecular and Cellular Biochemistry.2025; 480(12): 5995. CrossRef - Chrononutrition and sleep patterns in individuals with diabetes mellitus: Assessing misalignments and social jetlag
Micaela Rabelo Quadra, Fernanda Olivera Meller, Antônio Augusto Schäfer, Taísa Dimer Hendler, Emilio Luiz Streck
Chronobiology International.2025; 42(10): 1427. CrossRef - Effects of time-restricted eating on body composition and metabolic parameters in overweight and obese women: a systematic review and meta-analysis
Shiying Chen, Xiaotian Zhang, Jakub Kortas, Haitao Liu
Frontiers in Nutrition.2025;[Epub] CrossRef - The oncogenic role of BMAL2 in non-small cell lung cancer: MRPL15-mediated regulation of apoptosis and ferroptosis
Yang Liu, Yixia Li, Xiaotian Zhai, Lei Yang, Jie Li, Yi Han
Translational Oncology.2025; 62: 102560. CrossRef - Circadian Rhythm: Biological Functions, Diseases, and Therapeutic Targets
Kangkang Zha, Bobin Mi, Yuan Xiong, Shuyan Wu, Li Lu, Shengming Zhang, Xuan Lu, Hei Chung Mak, Jianping Huang, Adriana C. Panayi, Samuel Knoedler, Lili Chen, Guohui Liu, Sien Lin
MedComm.2025;[Epub] CrossRef
- Late-eating adolescents consume more energy, make poorer dietary choices, and are more likely to have excess weight: An analysis of the Brazilian Household Budget Survey (2008–2009)
First
Prev
