Diabetes & Metabolism Journal

Case Reports

Sphenoid Sinus Aspergillosis with Ophthalmoplegia that Occurred in Patients with Diabetes Mellitus.: Oh Dae Kwon, Jong Yup Bae; Korean Diabetes J. 2005;29(1):78-82. Published online January 1, 2005

Abstract PDF: Ophthalmoplegia that is caused by spheniod sinus aspergillosis is a rare disease. We report here on two cases of sphenoid sinus aspergillosis with diplopia that occurred in a diabetic patient and an immunocompetent patients. The diabetic patient showed a more rapid progression, severer symptoms and a delayed and incomplete recovery from the neurological deficits. The other patient had milder symptoms, a slower disease course and a more rapid recovery. We suggest that immediate imaging should be performed to diagnose the cause of diplopia in those patients presenting with atypical unilateral persistent facial pain and diplopia, and especially for those patient with diabetes mellitus

A Case of Invasive Aspergillosis of the Nasal Septum in a Patient with Diabetes Mellitus.: Tae Hoon Kim, Ji Sung Yoon, Ji O Mok, Yeo Joo Kim, Hyeong Kyu Park, Chul Hee Kim, Sang Jin Kim, Dong Won Byun, Kyo Il Suh, Myung Hi Yoo, Jang Mook Kim, Yoon Jung Kim; Korean Diabetes J. 2003;27(4):373-378. Published online August 1, 2003

Abstract PDF: Invasive aspergillosis of the nasal cavity and paranasal sinuses is characterized by invasion and destruction of the bony sinus walls, the orbit, and other soft tissues of the face. It occurs particularly in patients with severe immune deficits, and less frequently in patients with diabetes mellitus. The therapeutic outcome of invasive aspergillosis is unsatisfactory. Mortality rates range from 50 to 80%, depending primarily on the underlying disease. In general, the prognosis depends on making a prompt diagnosis of infection and providing early treatment. However the diagnosis of invasive aspergillosis is difficult because there is no specific symptom, nor any rapid diagnostic method for confirmation. We report a case of a 64-year old woman with diabetes mellitus and invasive aspergillosis of the nasal septum. She was diagnosed by biopsy of the nasal septum and treated with systemic antifungal agent and surgical debridement. (Ed- paragraphs combined here) In conjunction with this case we review the previous literatures and suggest that prompt antifungal therapy with glycemic control is an important element in the treatment of invasive aspergillosis in a diabetic patient.

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