Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
1 "Venkata Ramana Mallela"
Filter
Filter
Article category
Keywords
Publication year
Authors
Original Article
Genetics
Severity of Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus: Relationship between Nongenetic Factors and PNPLA3/HSD17B13 Polymorphisms
Mattia Bellan, Cosimo Colletta, Matteo Nazzareno Barbaglia, Livia Salmi, Roberto Clerici, Venkata Ramana Mallela, Luigi Mario Castello, Giuseppe Saglietti, Gian Piero Carnevale Schianca, Rosalba Minisini, Mario Pirisi
Diabetes Metab J. 2019;43(5):700-710.   Published online July 29, 2019
DOI: https://doi.org/10.4093/dmj.2018.0201
  • 5,861 View
  • 80 Download
  • 18 Web of Science
  • 19 Crossref
AbstractAbstract PDFPubReader   
Background

The prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM) is high, though its severity is often underestimated. Our aim is to provide an estimate of the prevalence of severe NAFLD in T2DM and identify its major predictors.

Methods

T2DM patients (n=328) not previously known to have NAFLD underwent clinical assessment, transient elastography with measure of liver stiffness (LS) and controlled attenuation parameter (CAP), and genotyping for patatin like phospholipase domain containing 3 (PNPLA3) and 17β-hydroxysteroid-dehydrogenase type 13 (HSD17B13).

Results

Median LS was 6.1 kPa (4.9 to 8.6). More than one-fourth patients had advanced liver disease, defined as LS ≥7.9 kPa (n=94/238, 29%), and had a higher body mass index (BMI) than those with a LS <7.9 kPa. Carriage of the G allele in the PNPLA3 gene was associated with higher LS, being 5.9 kPa (4.7 to 7.7) in C/C homozygotes, 6.1 kPa (5.2 to 8.7) in C/G heterozygotes, and 6.8 kPa (5.8 to 9.2) in G/G homozygotes (P=0.01). This trend was absent in patients with ≥1 mutated HSD17B13 allele. In a multiple linear regression model, BMI and PNPLA3 genotype predicted LS, while age, gender, disease duration, and glycosylated hemoglobin did not fit into the model. None of these variables was confirmed to be predictive among carriers of at least one HSD17B13 mutated allele. There was no association between CAP and polymorphisms of PNPLA3 or HSD17B13.

Conclusion

Advanced NAFLD is common among T2DM patients. LS is predicted by both BMI and PNPLA3 polymorphism, the effect of the latter being modulated by mutated HSD17B13.

Citations

Citations to this article as recorded by  
  • miRNA and lncRNA as potential tissue biomarkers in hepatocellular carcinoma
    Venkata Ramana Mallela, Marie Rajtmajerová, Andriy Trailin, Václav Liška, Kari Hemminki, Filip Ambrozkiewicz
    Non-coding RNA Research.2024; 9(1): 24.     CrossRef
  • 17-Beta-Hydroxysteroid Dehydrogenase 13 Loss of Function Does Not Confer Protection to Nonalcoholic Fatty Liver Disease in Indian Population
    Bale Govardhan, V. Kulkarni Anand, Padaki Nagaraja Rao, P. Balachandran Menon, Sharma Mithun, Mitnala Sasikala, T.R. Sowmya, Sekaran Anuradha, C. Pawar Smita, D. Nageshwar Reddy, Vishnubhotla Ravikanth
    Journal of Clinical and Experimental Hepatology.2024; 14(4): 101371.     CrossRef
  • The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease
    Facundo Maiorana, Magali Neschuk, María Virginia Caronia, Karina Elizondo, María Laura Robledo, Adolfo Schneider, Georgina Veron, Pedro Dario Zapata, Fernando Javier Barreyro, Shaghayegh Khanmohammadi
    PLOS ONE.2024; 19(9): e0310361.     CrossRef
  • PNPLA3 as a driver of steatotic liver disease: navigating from pathobiology to the clinics via epidemiology
    Ralf Weiskirchen, Amedeo Lonardo
    Journal of Translational Genetics and Genomics.2024; 8(4): 355.     CrossRef
  • Review article: the role of HSD17B13 on global epidemiology, natural history, pathogenesis and treatment of NAFLD
    Maral Amangurbanova, Daniel Q. Huang, Rohit Loomba
    Alimentary Pharmacology & Therapeutics.2023; 57(1): 37.     CrossRef
  • Identification of shared genetic architecture between non-alcoholic fatty liver disease and type 2 diabetes: A genome-wide analysis
    Yajing Tan, Qian He, Kei Hang Katie Chan
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Polymorphisms of HSD17B13, GCKR, HFE, and CP as factors of the development of non-alcoholic fatty liver disease and comorbid diseases
    O. V. Smirnova, D. V. Lagutinskaya
    Meditsinskiy sovet = Medical Council.2023; (8): 119.     CrossRef
  • Global prevalence of non-alcoholic fatty liver disease in type 2 diabetes mellitus: an updated systematic review and meta-analysis
    Elina En Li Cho, Chong Zhe Ang, Jingxuan Quek, Clarissa Elysia Fu, Lincoln Kai En Lim, Zane En Qi Heng, Darren Jun Hao Tan, Wen Hui Lim, Jie Ning Yong, Rebecca Zeng, Douglas Chee, Benjamin Nah, Cosmas Rinaldi Adithya Lesmana, Aung Hlaing Bwa, Khin Maung W
    Gut.2023; 72(11): 2138.     CrossRef
  • HSD17B13 and other liver fat-modulating genes predict development of hepatocellular carcinoma among HCV-positive cirrhotics with and without viral clearance after DAA treatment
    Michela E. Burlone, Mattia Bellan, Matteo N. Barbaglia, Ginevra Mocchetti, Venkata R. Mallela, Rosalba Minisini, Cristina Rigamonti, Mario Pirisi
    Clinical Journal of Gastroenterology.2022; 15(2): 301.     CrossRef
  • Influence of Type 2 Diabetes in the Association of PNPLA3 rs738409 and TM6SF2 rs58542926 Polymorphisms in NASH Advanced Liver Fibrosis
    Pablo Gabriel-Medina, Roser Ferrer-Costa, Francisco Rodriguez-Frias, Andreea Ciudin, Salvador Augustin, Jesus Rivera-Esteban, Juan M. Pericàs, David Martinez Selva
    Biomedicines.2022; 10(5): 1015.     CrossRef
  • Triglyceride and glucose index is a simple and easy‐to‐calculate marker associated with nonalcoholic fatty liver disease
    Kyung‐Soo Kim, Sangmo Hong, Hong‐Yup Ahn, Cheol‐Young Park
    Obesity.2022; 30(6): 1279.     CrossRef
  • Prevalence of elevated liver stiffness in patients with type 1 and type 2 diabetes: A systematic review and meta-analysis
    Stefano Ciardullo, Gianluca Perseghin
    Diabetes Research and Clinical Practice.2022; 190: 109981.     CrossRef
  • Associations of Hydroxysteroid 17-beta Dehydrogenase 13 Variants with Liver Histology in Chinese Patients with Metabolic-associated Fatty Liver Disease
    Wen-Yue Liu, Mohammed Eslam, Kenneth I. Zheng, Hong-Lei Ma, Rafael S. Rios, Min-Zhi Lv, Gang Li, Liang-Jie Tang, Pei-Wu Zhu, Xiao-Dong Wang, Christopher D. Byrne, Giovanni Targher, Jacob George, Ming-Hua Zheng
    Journal of Clinical and Translational Hepatology.2021; 000(000): 000.     CrossRef
  • Albuminuria Is Associated with Steatosis Burden in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease
    Eugene Han, Mi Kyung Kim, Byoung Kuk Jang, Hye Soon Kim
    Diabetes & Metabolism Journal.2021; 45(5): 698.     CrossRef
  • Genetic Polymorphisms and Clinical Features in Diabetic Patients With Fatty Liver: Results From a Single-Center Experience in Southern Italy
    Rosanna Villani, Grazia Pia Magnati, Giuseppe De Girolamo, Moris Sangineto, Antonino Davide Romano, Tommaso Cassano, Gaetano Serviddio
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Interplay of PNPLA3 and HSD17B13 Variants in Modulating the Risk of Hepatocellular Carcinoma among Hepatitis C Patients
    Carla De Benedittis, Mattia Bellan, Martina Crevola, Elena Boin, Matteo Nazzareno Barbaglia, Venkata Ramana Mallela, Paolo Ravanini, Elisa Ceriani, Stefano Fangazio, Pier Paolo Sainaghi, Michela Emma Burlone, Rosalba Minisini, Mario Pirisi
    Gastroenterology Research and Practice.2020; 2020: 1.     CrossRef
  • Toward Genetic Prediction of Nonalcoholic Fatty Liver Disease Trajectories: PNPLA3 and Beyond
    Marcin Krawczyk, Roman Liebe, Frank Lammert
    Gastroenterology.2020; 158(7): 1865.     CrossRef
  • The effect of liraglutide on nonalcoholic fatty liver disease in type 2 diabetes mellitus
    Xueyang Zhang, Ran Bai, Yong Jia, Junwei Zong, Yongbo Wang, Yanan Dong
    International Journal of Diabetes in Developing Countries.2020; 40(4): 491.     CrossRef
  • Lifestyle and silymarin: a fight against liver damage in NAFLD associated - prediabetic disease
    Cosimo Colletta, Alessandro Colletta, Giuseppe Placentino
    Journal of Diabetes & Metabolic Disorders.2020; 19(2): 883.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP