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- Risk Prediction and Management of Chronic Kidney Disease in People Living with Type 2 Diabetes Mellitus
- Ying-Guat Ooi, Tharsini Sarvanandan, Nicholas Ken Yoong Hee, Quan-Hziung Lim, Sharmila S. Paramasivam, Jeyakantha Ratnasingam, Shireene R. Vethakkan, Soo-Kun Lim, Lee-Ling Lim
- Diabetes Metab J. 2024;48(2):196-207. Published online January 26, 2024
- DOI: https://doi.org/10.4093/dmj.2023.0244
- 11,920 View
- 676 Download
- 7 Web of Science
- 8 Crossref
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Abstract
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Supplementary Material
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ePub - People with type 2 diabetes mellitus have increased risk of chronic kidney disease and atherosclerotic cardiovascular disease. Improved care delivery and implementation of guideline-directed medical therapy have contributed to the declining incidence of atherosclerotic cardiovascular disease in high-income countries. By contrast, the global incidence of chronic kidney disease and associated mortality is either plateaued or increased, leading to escalating direct and indirect medical costs. Given limited resources, better risk stratification approaches to identify people at risk of rapid progression to end-stage kidney disease can reduce therapeutic inertia, facilitate timely interventions and identify the need for early nephrologist referral. Among people with chronic kidney disease G3a and beyond, the kidney failure risk equations (KFRE) have been externally validated and outperformed other risk prediction models. The KFRE can also guide the timing of preparation for kidney replacement therapy with improved healthcare resources planning and may prevent multiple complications and premature mortality among people with chronic kidney disease with and without type 2 diabetes mellitus. The present review summarizes the evidence of KFRE to date and call for future research to validate and evaluate its impact on cardiovascular and mortality outcomes, as well as healthcare resource utilization in multiethnic populations and different healthcare settings.
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Citations
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- Integrated SERS-magnetic capture platform for multiplex detection of early tubular injury biomarkers in diabetic kidney disease progression
Wendi Cao, Sirui Yang, Zhenhua Zhao, Xuelin Chen, Tenglong Liu, Xinran Yang, Leshan Cai, Xiaozhe Lin, Xia Zhou, Qiaoxin Zhang
Sensors and Actuators Reports.2026; 11: 100412. CrossRef - A Machine Learning-Based Prediction Model for Diabetic Kidney Disease in Korean Patients with Type 2 Diabetes Mellitus
Kyung Ae Lee, Jong Seung Kim, Yu Ji Kim, In Sun Goak, Heung Yong Jin, Seungyong Park, Hyejin Kang, Tae Sun Park
Journal of Clinical Medicine.2025; 14(6): 2065. CrossRef - Chronic Kidney Disease in Diabetes: A Clinical Practice Guideline
Sheldon W. Tobe, Harpreet S. Bajaj, Navdeep Tangri, Rahul Jain, Thuy Pham, Valerie Beaudin, Phil McFarlane
Canadian Journal of Diabetes.2025; 49(2): 73. CrossRef - Kidney failure risk equation (KFRE), A risk-based triage for nephrology referrals: A mixed-methods study at pre-implementation phase among healthcare providers
Nur Raziana Rozi, Christine Shamala Selvaraj, Jia-Kai Tan, Zhan-Foong Lim, Noor Wahidah Nordin, Nuqman Hakimi Mazhar, Haris Hafizal, Hooi-Chin Beh, Quan-Hziung Lim, Ying-Guat Ooi, Adina Abdullah, Wan Ahmad Hafiz Wan Md Adnan, Pavai Sthaneswar, Soo-Kun Lim
Primary Care Diabetes.2025; 19(6): 636. CrossRef - Construction and validation of a clinical prediction model for diabetic ketoacidosis
Chen Xu, Xingwen Jiang, Quanan He, Peng Xu
Frontiers in Medicine.2025;[Epub] CrossRef - External validation, recalibration, and clinical utility of the kidney failure risk equation in patients with advanced CKD: a nationwide retrospective cohort analysis in Peru
Jessica Ivonne Bravo-Zúñiga, Percy Soto-Becerra, Edgar Juan Coila-Paricahua, Ricardo Chávez-Gómez, Eduardo Pérez-Tejada, Anselma Victoria Pardo-Villafranca, Lizbeth Carmen Arce-Gallo, Daysi Diaz-Obregón
BMC Nephrology.2025;[Epub] CrossRef - Reprint of: Chronic Kidney Disease in Diabetes: A Clinical Practice Guideline
Sheldon W. Tobe, Harpreet S. Bajaj, Navdeep Tangri, Rahul Jain, Thuy Pham, Valerie Beaudin, Phil McFarlane
Canadian Journal of Diabetes.2025; 49: 7. CrossRef - Prevalence of diabetes and its associated factors in Cape Verde: an analysis of the 2020 WHO STEPS survey on non-communicable diseases risk factors
Joshua Okyere, Castro Ayebeng, Kwamena Sekyi Dickson
BMC Endocrine Disorders.2024;[Epub] CrossRef
- Integrated SERS-magnetic capture platform for multiplex detection of early tubular injury biomarkers in diabetic kidney disease progression
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