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1 "Mutsuhiro Kobayashi"
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Original Article
Impact of Serum Triglyceride and High Density Lipoprotein Cholesterol Levels on Early-Phase Insulin Secretion in Normoglycemic and Prediabetic Subjects
Masanori Shimodaira, Tomohiro Niwa, Koji Nakajima, Mutsuhiro Kobayashi, Norinao Hanyu, Tomohiro Nakayama
Diabetes Metab J. 2014;38(4):294-301.   Published online August 20, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.4.294
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  • 15 Web of Science
  • 14 Crossref
AbstractAbstract PDFPubReader   
Background

Increased triglycerides (TGs) and decreased high density lipoprotein cholesterol (HDL-C) levels are established as diabetic risks for nondiabetic subjects. The aim of this study was to investigate the relationship among TG, HDL-C, TG/HDL-C ratio, and early-phase insulin secretion in normoglycemic and prediabetic subjects.

Methods

We evaluated 663 Japanese subjects who underwent the 75-g oral glucose tolerance test. On the basis of these results, the subjects were divided into four groups: those with normal glucose tolerance (NGT; n=341), isolated impaired fasting glucose (i-IFG; n=211), isolated impaired glucose tolerance (i-IGT; n=71), and combined IFG and IGT (IFG+IGT; n=40). Insulin secretion was estimated by the insulinogenic index (IGI) (Δinsulin/Δglucose [30 to 0 minutes]) and disposition index (DI) (IGI/homeostasis model assessment of insulin resistance).

Results

In prediabetic subjects (i-IFG, i-IGT, and IFG+IGT), linear regression analyses revealed that IGI and DI were positively correlated with HDL-C levels. Moreover, in subjects with i-IGT and (IFG+IGT), but not with i-IFG, the indices of insulin secretion were negatively correlated with the log-transformed TG and TG/HDL-C ratio. In both the subjects with i-IGT, multivariate linear regression analyses revealed that DI was positively correlated with HDL-C and negatively with log-transformed TG and TG/HDL-C ratio. On the other hand, in subjects with NGT, there was no association between insulin secretion and lipid profiles.

Conclusion

These results revealed that serum TG and HDL-C levels have different impacts on early-phase insulin secretion on the basis of their glucose tolerance status.

Citations

Citations to this article as recorded by  
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    Sudan Wang, Xiaoyan Qian, Chao Shen, Qian Sun, Yang Jing, Bingyue Liu, Kexin Zhang, Mengyuan Li, Junrong Wang, Hui Zhou, Chen Dong
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Interaction between the GCKR rs1260326 variant and serum HDL cholesterol contributes to HOMA-β and ISIMatusda in the middle-aged T2D individuals
    Min Shen, Liying Jiang, Hechun Liu, Hao Dai, Hemin Jiang, Yu Qian, Zhixiao Wang, Shuai Zheng, Heng Chen, Tao Yang, Qi Fu, Kuanfeng Xu
    Journal of Human Genetics.2023; 68(12): 835.     CrossRef
  • Elevated triglyceride/high-density lipoprotein-cholesterol ratio as a risk factor for progression to prediabetes: a 5-year retrospective cohort study in Japan
    Masanori Shimodaira, Yu Minemura, Tomohiro Nakayama
    Journal of Diabetes & Metabolic Disorders.2023;[Epub]     CrossRef
  • Association ofTG/HDLCratio trajectory and risk of type 2 diabetes: A retrospective cohort study inChina
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    Journal of Diabetes.2021; 13(5): 402.     CrossRef
  • Triglycerides/high-density lipoprotein cholesterol is a predictor similar to the triglyceride–glucose index for the diagnosis of metabolic syndrome using International Diabetes Federation criteria of insulin resistance in obese adolescents: a cross-sectio
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    Journal of Pediatric Endocrinology and Metabolism.2020; 33(6): 777.     CrossRef
  • Comparison of Serum PCSK9 Levels in Subjects with Normoglycemia, Impaired Fasting Glucose, and Impaired Glucose Tolerance
    Eugene Han, Nan Hee Cho, Seong-Su Moon, Hochan Cho
    Endocrinology and Metabolism.2020; 35(2): 480.     CrossRef
  • Triglycerides/glucose index is a useful surrogate marker of insulin resistance among adolescents
    B Kang, Y Yang, E Y Lee, H K Yang, H-S Kim, S-Y Lim, J-H Lee, S-S Lee, B-K Suh, K-H Yoon
    International Journal of Obesity.2017; 41(5): 789.     CrossRef
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    European Journal of Clinical Investigation.2016; 46(2): 189.     CrossRef
  • TyG Index Change Is More Determinant for Forecasting Type 2 Diabetes Onset Than Weight Gain
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  • Comparative analysis of the efficacy of omega-3 fatty acids for hypertriglyceridaemia management in Korea
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    Journal of Clinical Pharmacy and Therapeutics.2016; 41(5): 508.     CrossRef
  • Relationship between insulin sensitivity and insulin secretion rate: not necessarily hyperbolic
    S. H. Kim, A. Silvers, J. Viren, G. M. Reaven
    Diabetic Medicine.2016; 33(7): 961.     CrossRef
  • The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance but not of β cell function in a Chinese population with different glucose tolerance status
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    Lipids in Health and Disease.2016;[Epub]     CrossRef
  • Interactive effects of C-reactive protein levels on the association between APOE variants and triglyceride levels in a Taiwanese population
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    Lipids in Health and Disease.2016;[Epub]     CrossRef
  • Lipoproteins and β-Cell Functions: From Basic to Clinical Data
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    Diabetes & Metabolism Journal.2014; 38(4): 274.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal