Diabetes & Metabolism Journal

Original Articles

Basic research
Reducing Oxidative Stress and Inflammation by Pyruvate Dehydrogenase Kinase 4 Inhibition Is Important in Prevention of Renal Ischemia-Reperfusion Injury in Diabetic Mice: Ah Reum Khang, Dong Hun Kim, Min-Ji Kim, Chang Joo Oh, Jae-Han Jeon, Sung Hee Choi, In-Kyu Lee; Diabetes Metab J. 2024;48(3):405-417. Published online February 1, 2024; DOI: https://doi.org/10.4093/dmj.2023.0196

9,576 View
405 Download
12 Web of Science
13 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Reactive oxygen species (ROS) and inflammation are reported to have a fundamental role in the pathogenesis of ischemia-reperfusion (IR) injury, a leading cause of acute kidney injury. The present study investigated the role of pyruvate dehydrogenase kinase 4 (PDK4) in ROS production and inflammation following IR injury.
Methods
We used a streptozotocin-induced diabetic C57BL6/J mouse model, which was subjected to IR by clamping both renal pedicles. Cellular apoptosis and inflammatory markers were evaluated in NRK-52E cells and mouse primary tubular cells after hypoxia and reoxygenation using a hypoxia work station.
Results
Following IR injury in diabetic mice, the expression of PDK4, rather than the other PDK isoforms, was induced with a marked increase in pyruvate dehydrogenase E1α (PDHE1α) phosphorylation. This was accompanied by a pronounced ROS activation, as well as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), and monocyte chemoattractant protein-1 (MCP-1) production. Notably, sodium dichloroacetate (DCA) attenuated renal IR injury-induced apoptosis which can be attributed to reducing PDK4 expression and PDHE1α phosphorylation levels. DCA or shPdk4 treatment reduced oxidative stress and decreased TNF-α, IL-6, IL-1β, and MCP-1 production after IR or hypoxia-reoxygenation injury.
Conclusion
PDK4 inhibition alleviated renal injury with decreased ROS production and inflammation, supporting a critical role for PDK4 in IR mediated damage. This result indicates another potential target for reno-protection during IR injury; accordingly, the role of PDK4 inhibition needs to be comprehensively elucidated in terms of mitochondrial function during renal IR injury.

Citations

Citations to this article as recorded by

Advancements in early biomarkers of acute kidney injury: from traditional indicators to a paradigm shift in lactate metabolism
Qian Wu, Xinyi Qiu, Hongyu Chen
Annals of Medicine.2026;[Epub] CrossRef
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease
Tingting Fu, Shengnan Sun, Zhiye Wang, Fang Zhao, Junhui Zhen, Xingzhao Ji, Fuyuan Xue, Qian Mu, Ying Wang, Yi Liu, Qiang Wan
Cardiovascular Diabetology.2026;[Epub] CrossRef
Persistent subclinical renal injury in female rats following renal ischemia-reperfusion injury
Desmond Moronge, Hannah Godley, Victor Ayulo, Elisabeth Mellott, Mona Elgazzaz, Gibson Cooper, Riyaz Mohamed, Safia Ogbi, Ellen Gillis, Jessica L. Faulkner, Jennifer C. Sullivan
Clinical Science.2025; 139(04): 309. CrossRef
Edaravone dexborneol exerts anti-epileptic effects on rodent temporal lobe epilepsy by promoting NMDAR deactivation and inhibiting oxidative stress
Wanhua Qiu, Roumeng Chen, Lechen Pan, Yiqian Li, Yuchen Xu, Yuqian Li, Ang Guo, Wenting Huang, Tao Tan, Peijun Li, Chenglong Xie, Huiqin Xu, Li Lin, Xinshi Wang
Phytomedicine.2025; 140: 156558. CrossRef
Cardiac PDK4 promotes neutrophilic PFKL methylation and drives the innate immune response in diabetic myocardial infarction
Song Yang, Longxin Yan, Lang Chen, Gaijuan Su, Long Yang, Lili Gong, Lihong Liu
Pharmacological Research.2025; 215: 107731. CrossRef
Targeting HDAC3 Suppresses Ferroptosis and Demyelination in White Matter Injury by Restoring PDK4‐Mediated Iron Homeostasis
Ting Xu, Lisha Ye, Wenfeng Li, Fangming Liu, Tianjiao Wei, Wenhui Gu, Lihua Xu, Mingde Fang, Qianqian Luo, Chuanjie Wu, Guohua Wang
CNS Neuroscience & Therapeutics.2025;[Epub] CrossRef
Advances in the therapeutic applications of dichloroacetate as a metabolic regulator: A review
Xiaohuan Wu, Min Shang, Meichuan Li, Yujuan Liu, Han Hu, Ping Zhang, Qiuyi He, Shide Lin
Medicine.2025; 104(36): e44295. CrossRef
Depression, anxiety, and stress impair sperm quality via dysregulation of the mitochondrial PDK–PDC axis
Wang Wang, Wang Qikai, Wang Zilin, Shao Junyan, Jiang Xiaocui, Liu Qi, Chen Shuhui, Zhu Yangyang, Gao Mengjie, Chen Siyi, Cao Jigang, Xiao Min
Reproductive Biology and Endocrinology.2025;[Epub] CrossRef
Integrating Metabolomics LC-HRMS, and Network Pharmacology of Garcinia forbesii King Leaf Extract, Potential for Treatment of Renal Ischemic Reperfusion Injury
Azma Rosida, Nia Kania, Mohammad Rudiansyah, Fujiati Fujiati, Oski Illiandri, Wivina R Devi
Tropical Journal of Natural Product Research.2025;[Epub] CrossRef
Identification and validation of mitochondrial-related genes in intestinal ischemia-reperfusion injury based on WGCNA and machine learning
YiChen Hu, Jie Huang, XiaoLi Min, YuanPei Zhao, JiaHui Wang, HongYuan Liu, KaiWen Shi, WenLiang Li, WeiMing Li
Frontiers in Molecular Biosciences.2025;[Epub] CrossRef
Exploring Renal Pyruvate Metabolism as a Therapeutic Avenue for Diabetic Kidney Injury
Jaemin Lee
Diabetes & Metabolism Journal.2024; 48(3): 385. CrossRef
Cardiovascular Disease and miRNAs: Possible Oxidative Stress-Regulating Roles of miRNAs
Seahyoung Lee
Antioxidants.2024; 13(6): 656. CrossRef
Sodium Phenylbutyrate Attenuates Cisplatin-Induced Acute Kidney Injury Through Inhibition of Pyruvate Dehydrogenase Kinase 4
Chang Joo Oh, Wooyoung Choi, Ha Young Lee, In-Kyu Lee, Min-Ji Kim, Jae-Han Jeon
Biomedicines.2024; 12(12): 2815. CrossRef

Basic Research
CycloZ Improves Hyperglycemia and Lipid Metabolism by Modulating Lysine Acetylation in KK-Ay Mice: Jongsu Jeon, Dohyun Lee, Bobae Kim, Bo-Yoon Park, Chang Joo Oh, Min-Ji Kim, Jae-Han Jeon, In-Kyu Lee, Onyu Park, Seoyeong Baek, Chae Won Lim, Dongryeol Ryu, Sungsoon Fang, Johan Auwerx, Kyong-Tai Kim, Hoe-Yune Jung; Diabetes Metab J. 2023;47(5):653-667. Published online April 26, 2023; DOI: https://doi.org/10.4093/dmj.2022.0244

8,133 View
261 Download
5 Web of Science
6 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
CycloZ, a combination of cyclo-His-Pro and zinc, has anti-diabetic activity. However, its exact mode of action remains to be elucidated.
Methods
KK-Ay mice, a type 2 diabetes mellitus (T2DM) model, were administered CycloZ either as a preventive intervention, or as a therapy. Glycemic control was evaluated using the oral glucose tolerance test (OGTT), and glycosylated hemoglobin (HbA1c) levels. Liver and visceral adipose tissues (VATs) were used for histological evaluation, gene expression analysis, and protein expression analysis.
Results
CycloZ administration improved glycemic control in KK-Ay mice in both prophylactic and therapeutic studies. Lysine acetylation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha, liver kinase B1, and nuclear factor-κB p65 was decreased in the liver and VATs in CycloZ-treated mice. In addition, CycloZ treatment improved mitochondrial function, lipid oxidation, and inflammation in the liver and VATs of mice. CycloZ treatment also increased the level of β-nicotinamide adenine dinucleotide (NAD⁺), which affected the activity of deacetylases, such as sirtuin 1 (Sirt1).
Conclusion
Our findings suggest that the beneficial effects of CycloZ on diabetes and obesity occur through increased NAD⁺ synthesis, which modulates Sirt1 deacetylase activity in the liver and VATs. Given that the mode of action of an NAD+ booster or Sirt1 deacetylase activator is different from that of traditional T2DM drugs, CycloZ would be considered a novel therapeutic option for the treatment of T2DM.

Citations

Citations to this article as recorded by

Beneficial Effects of a Novel Fructose-1,6-Bisphosphatase Inhibitor Cpd96 on Insulin Secretion in Type 2 Diabetes
Kejia Xu, Jiaxuan Zhao, Liran Lei, Quan Liu, Hui Cao, Caina Li, Yi Huan, Xinqian Geng, Lin Zhang, Xi Cao, Ying Yang, Yongzhao Mu, Rongcui Li, Zhufang Shen, Lei Lei, Shuainan Liu
ACS Pharmacology & Translational Science.2026; 9(1): 153. CrossRef
Microwave Pretreatment-Induced Significant Nutrient and Metabolite Changes in Sea Cucumber Apostichopus japonicus
Dairong Song, Fang Liu, Airong Jia, Xue Liu, Tingting Cui, Hui Zhang, Miansong Zhang
Marine Drugs.2025; 23(6): 249. CrossRef
Distinct types of protein modifications in diabetic endothelial dysfunction
Qianyou Zhou, Xintong Ge, Zhaojing Chen, Danyi Cao, Yun Chen, Jiahai Shi, Guoliang Meng
Cardiovascular Diabetology.2025;[Epub] CrossRef
Cyclo His‐Pro Attenuates Muscle Degeneration in Murine Myopathy Models
Alessia De Masi, Nadège Zanou, Keno Strotjohann, Dohyun Lee, Tanes I. Lima, Xiaoxu Li, Jongsu Jeon, Nicolas Place, Hoe‐Yune Jung, Johan Auwerx
Advanced Science.2024;[Epub] CrossRef
CycloZ Suppresses TLR4-Driven Inflammation to Reduce Asthma-Like Responses in HDM-Exposed Mouse Models
Dohyun Lee, Jongsu Jeon, Seoyeong Baek, Onyu Park, Ah-Ram Kim, Myoung-Sool Do, Hoe-Yune Jung
Cells.2024; 13(23): 2034. CrossRef
Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases
Lorena Martínez-Alcantar, Laura Hernández-Padilla, Alma Laura Díaz-Pérez, Lizbeth Guadalupe Villalón-Magallán, Mayra Xóchitl Durán-Maldonado, César Díaz-Pérez, Marlene E. Campos-Morales, Citlali Figueroa-Guzmán, Jesús Campos-García
Kinases and Phosphatases.2024; 2(4): 346. CrossRef

Review

Basic Research
The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4: Min-Ji Kim, Ibotombi Singh Sinam, Zerwa Siddique, Jae-Han Jeon, In-Kyu Lee; Diabetes Metab J. 2023;47(2):153-163. Published online January 12, 2023; DOI: https://doi.org/10.4093/dmj.2022.0305

16,148 View
652 Download
44 Web of Science
46 Crossref

Abstract PDF PubReader ePub

Sarcopenia, defined as a progressive loss of muscle mass and function, is typified by mitochondrial dysfunction and loss of mitochondrial resilience. Sarcopenia is associated not only with aging, but also with various metabolic diseases characterized by mitochondrial dyshomeostasis. Pyruvate dehydrogenase kinases (PDKs) are mitochondrial enzymes that inhibit the pyruvate dehydrogenase complex, which controls pyruvate entry into the tricarboxylic acid cycle and the subsequent adenosine triphosphate production required for normal cellular activities. PDK4 is upregulated in mitochondrial dysfunction-related metabolic diseases, especially pathologic muscle conditions associated with enhanced muscle proteolysis and aberrant myogenesis. Increases in PDK4 are associated with perturbation of mitochondria-associated membranes and mitochondrial quality control, which are emerging as a central mechanism in the pathogenesis of metabolic disease-associated muscle atrophy. Here, we review how mitochondrial dysfunction affects sarcopenia, focusing on the role of PDK4 in mitochondrial homeostasis. We discuss the molecular mechanisms underlying the effects of PDK4 on mitochondrial dysfunction in sarcopenia and show that targeting mitochondria could be a therapeutic target for treating sarcopenia.

Citations

Citations to this article as recorded by

From aging to space: A comparative biology of skeletal muscle degeneration
Rizwan Qaisar
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2026; 1872(1): 168058. CrossRef
High-concentration Mg2+ stress improves L-lactic acid biosynthesis of Bacillus coagulans revealed by combined analysis of transcriptome and metabolome
Zhitong Sun, Jiaxin Liang, Gang Wang, Yumeng Zhen, Jinlong Liu, Di Cai, Bin Wang, Yong Wang
Journal of Biotechnology.2026; 409: 1. CrossRef
Repairing muscle with broccoli-derived sulforaphane: A preclinical evaluation for the treatment of mitochondrial myopathies
Thomas Lilley, Donny M. Camera, Faith A.A. Kwa
Drug Discovery Today.2025; 30(1): 104283. CrossRef
Could Sarcopenia Be Related to Chemotherapy in Gastrointestinal Cancer? A Cross-Sectional Study Including Comprehensive Geriatric Assessment
Kamile Sılay, Gökhan Uçar, Tülay Eren, Hande Selvi Öztorun, Ozan Yazıcı, Nuriye Özdemir
Journal of Clinical Medicine.2025; 14(3): 711. CrossRef
The association of body roundness index and body mass index with frailty and all-cause mortality: a study from the population aged 40 and above in the United States
Jianqiang Zhang, Huifeng Zhang
Lipids in Health and Disease.2025;[Epub] CrossRef
Near Infrared‐Mediated Intracellular NADH Delivery Strengthens Mitochondrial Function and Stability in Muscle Dysfunction Model
Hui Bang Cho, Hye‐Ryoung Kim, Sujeong Lee, Chae Won Cho, Ji‐In Park, Seulki Youn, Gyuwon So, Sumin Kang, Hye Jin Kim, Keun‐Hong Park
Advanced Science.2025;[Epub] CrossRef
The Association Between Low Muscle Mass and the Risk of Depressive Symptoms: A Cross‐Sectional Study Based on the Chinese Longitudinal Health Longevity Survey (CLHLS)
Yuting Yang, Yan Wang, Qiao Chen, Ling Li, Wangping Jia
Brain and Behavior.2025;[Epub] CrossRef
Type 3 diabetes and metabolic reprogramming of brain neurons: causes and therapeutic strategies
Xiangyuan Meng, Hui Zhang, Zhenhu Zhao, Siyao li, Xin Zhang, Ruihan Guo, Huimin Liu, Yiling Yuan, Wanrui Li, Qi Song, Jinyu Liu
Molecular Medicine.2025;[Epub] CrossRef
Dipalmitoylphosphatidylcholine Lipid Vesicles for Delivering HMB, NMN, and L-Leucine in Sarcopenia Therapy
Alfred Najm, Alexandra Cătălina Bîrcă, Adelina-Gabriela Niculescu, Adina Alberts, Alexandru Mihai Grumezescu, Bianca Gălățeanu, Bogdan Ștefan Vasile, Mircea Beuran, Bogdan Severus Gaspar, Ariana Hudiță
Molecules.2025; 30(7): 1437. CrossRef
Renometabolic disorder in experimental rat model of polycystic ovarian syndrome is reversed by acetate-mediated inhibition of pyruvate dehydrogenase kinase 4
Stephanie E. Areloegbe, Chukwubueze L. Atuma, Ayodeji Aturamu, Isaac O. Ajadi, Oluseyi E. Adelekan, Mary B. Ajadi, Christopher O. Akintayo, Gloria O. Omoruyi, Samuel O. Onyekweli, Omosola F. Anifowose, Oluwatobi A. Amusa, Kayode Ajayi, Paul A. Oyewole, To
BMC Nephrology.2025;[Epub] CrossRef
Unraveling the Metabolic Pathways Between Metabolic-Associated Fatty Liver Disease (MAFLD) and Sarcopenia
Marina Ribas Losasso, Maria Luiza Cesto Parussolo, Antony Oliveira Silva, Rosa Direito, Karina Quesada, Claudia Rucco Penteado Detregiachi, Marcelo Dib Bechara, Nahum Méndez-Sánchez, Ludovico Abenavoli, Adriano Cressoni Araújo, Ricardo de Alvares Goulart,
International Journal of Molecular Sciences.2025; 26(10): 4673. CrossRef
Mechanisms of aristolochic acid I Hepatotoxicity: Central role of PDK4-Induced mitochondrial dysfunction and hepatic inflammation
Zhaobin Wang, Kunyang Li, Xiaoqi Yi, Yichen Wu, Yang Zhao, Pingping He, Qinghua Zeng, Enxiang Zhang
Food and Chemical Toxicology.2025; 203: 115592. CrossRef
FOXK2 in skeletal muscle development: a new pathogenic gene for congenital myopathy with ptosis
Peixuan Wu, Nan Song, Yang Xiang, Zhe Tao, Bing Mao, Ruochen Guo, Xin Wang, Dan Wu, Zhenzhen Zhang, Xin Chen, Duan Ma, Tianyu Zhang, Bingtao Hao, Jing Ma
EMBO Molecular Medicine.2025; 17(7): 1599. CrossRef
Molecular Network Analysis and Effector Gene Prioritization of Endurance-Training-Influenced Modulation of Cardiac Aging
Mingrui Wang, Samuhaer Azhati, Hangyu Chen, Yanyan Zhang, Lijun Shi
Genes.2025; 16(7): 814. CrossRef
Therapeutic advances in sarcopenia management: From traditional interventions to personalized medicine
Xiangliang Liu, Xinqiao Chen, Jiuwei Cui
Clinical Nutrition.2025; 51: 187. CrossRef
An in vitro model to study molecular pathogenesis of sarcopenia established by a SASP-dependent human myotube culture
Kiyo-aki Ishii, Ryo Hashimoto, Chikako Umeda, Tohru Hosoyama, Ken Watanabe, Keisuke Hitachi
PLOS One.2025; 20(7): e0326968. CrossRef
Postbiotic Intervention in Sarcopenia: The Role of Lactiplantibacillus plantarum HY7715 and Its Extracellular Vesicles
Kippeum Lee, Soo Dong Park, Joo Yun Kim, Jae Jung Shim, Jae Hwan Lee
Life.2025; 15(7): 1101. CrossRef
Targeting ALDH2 to promote skeletal muscle health: A novel strategy against mitochondrial dysfunction
Katia S. G. Andrade, Jianming Liu, Dimitrius Santiago P. S. F. Guimarães, Julio C.B. Ferreira, Zhigao Wang, Da‐Zhi Wang, Leonardo R. Silveira
The Journal of Physiology.2025; 603(16): 4483. CrossRef
Healthy Dietary Patterns and Risk of Sarcopenia in Adults Aged > 50 Years: A Systematic Review and Meta-Analysis Considering EWGSOP1 and EWGSOP2 Criteria
Roxana E. Ruiz-Valenzuela, Reyes Artacho, María Dolores Ruiz-López, Esther Molina-Montes
Nutrients.2025; 17(17): 2764. CrossRef
The Role of Methylmalonic Acid in the Risk of Sarcopenia and All‐Cause Mortality Among Individuals With Sarcopenia: Evidence From NHANES
Ping Zhu, Jie Zhang, Xue‐Chun Liu, Ming Song, Bin Lu, Zhi‐Cheng Yang, Hui Pan, Ya‐Qiong Jiao, Ya‐Fei Guo, Fang‐Fang Chen, Zhi‐Hao Wang, Bo‐Ang Hu, Ming Zhong
Food Science & Nutrition.2025;[Epub] CrossRef
Mechanical Stimulation Induces Yap Mediated OCTN2 Transcription to Enhance Carnitine Metabolism in Sarcopenia
Yahong Lu, Yu Bai, Weiqing Li, Zhiguo Zhou, Heihuan Lai, Xingyu Hu, Tao Yang, Chendi Wang, Yitao Chen, Keping Gan, Kechi Li, Haiwei Ma, Lin Shen, Dengwei He
Journal of Cachexia, Sarcopenia and Muscle.2025;[Epub] CrossRef
Skeletal muscle alterations in type 2 diabetes mellitus with and without dyslipidemia
Safak Yigit, Busra Ulker Eksi, Ilhan Satman, Damla Korkmaz Dayican, Fulya Calikoglu, Humeyra Rekali Sahin, Francesco Perone, Buket Akinci
Lipids in Health and Disease.2025;[Epub] CrossRef
Loganin, an Iridoid Glycoside, Alleviates Paclitaxel‐Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence
Yu‐Fan Chuang, Cai‐Rong Wu, Wan‐Hsuan Chang, Ying‐Jung Su, Hung‐Te Hsu, Fan‐Li Lin, Yi‐Ching Lo
The Kaohsiung Journal of Medical Sciences.2025;[Epub] CrossRef
Targeting mitochondrial transporters and metabolic reprogramming for disease treatment
Mboneye Anselme, Huafeng He, Chengyang Lai, Wenwei Luo, Shilong Zhong
Journal of Translational Medicine.2025;[Epub] CrossRef
Amino acid metabolic signatures of dynapenic obesity in older adults: a (principal component analysis) PCA-based sex-stratified analysis in the Bushehr elderly health program
Maryam kheirandish, Neda Cheraghloo, Nafiseh Tavasoli, Farideh Razi, Farima Farsi, Atefeh Amrollahi Bioky, Hamid Reza Aghaei Meybodi, Kazem Khalagi, Ramin Heshmat, Niloufar Najjar, Maryam Amini Shirkouhi, Iraj Nabipour, Gita Shafiee, Bagher Larijani
Journal of Diabetes & Metabolic Disorders.2025;[Epub] CrossRef
PDK4 is critical for metabolic regulation and progesterone production in bovine granulosa cells
Xuelian Tao, Dirk Koczan, Julia Brenmoehl, Jens Vanselow, Vijay Simha Baddela
Biology of Reproduction.2025;[Epub] CrossRef
The canonical ER stress IRE1α/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia
Aniket S Joshi, Meiricris Tomaz da Silva, Anh Tuan Vuong, Bowen Xu, Ravi K Singh, Ashok Kumar
EMBO Molecular Medicine.2025; 17(12): 3607. CrossRef
Genomic Insights into Bear Hibernation
Blair W. Perry, Heiko T. Jansen, Alexis N. Enstrom, Joanna L. Kelley
Annual Review of Genetics .2025; 59(1): 147. CrossRef
From mitochondrial dysfunction to frailty and sarcopenia: genetic evidence from multi-omics data via Mendelian randomization and colocalization
Abudunaibi Wupuer, Xing Peng, Jie Wang, Yihan Li, Kaidiriyan Kuribanjiang, Shikang Yan, Lei Yang, Gustavo Duque
The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences.2025;[Epub] CrossRef
Recent advances in the research of sarcopenia in colorectal cancer
Yang Wang, Yuliuming Wang, Ming Liu
Holistic Integrative Oncology.2025;[Epub] CrossRef
Metabolic score for visceral fat as a superior predictor of frailty in overweight and obese adults: a cross-sectional NHANES analysis (2007–2020)
Yiming Zhan, Jeffrey William Ripley-Gonzalez, Yuhang Liu, Yang Gao, Jialing Tang, Siyao Gao
Diabetology & Metabolic Syndrome.2025;[Epub] CrossRef
PROPHYLACTIC EFFICACY OF GLYCOSIDES RICH STANDARDIZED FENUGREEK SEED EXTRACT ON EXPERIMENTAL RENAL INTERSTITIAL FIBROSIS IN MICE
PRASAD THAKURDESAI, ROHINI PUJARI
International Journal of Pharmacy and Pharmaceutical Sciences.2025; : 42. CrossRef
Synthesis, activatory effects, molecular docking and ADME studies as rabbit muscle pyruvate kinase activators of ureido phenyl substituted 1,4-dihydropyridine derivatives
Mustafa Oğuzhan Kaya, Tuna Demirci, Ümit Çalışır, Oğuzhan Özdemir, Yeşim Kaya, Mustafa Arslan
Research on Chemical Intermediates.2024; 50(1): 437. CrossRef
Unraveling the causes of sarcopenia: Roles of neuromuscular junction impairment and mitochondrial dysfunction
Yanmei Miao, Leiyu Xie, Jiamei Song, Xing Cai, Jinghe Yang, Xinglong Ma, Shaolin Chen, Peng Xie
Physiological Reports.2024;[Epub] CrossRef
Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases
Zonghao Qian, Yuzhen Huang, Yucong Zhang, Ni Yang, Ziwei Fang, Cuntai Zhang, Le Zhang
Frontiers in Genetics.2024;[Epub] CrossRef
Inhibition of Pyruvate Dehydrogenase Kinase 4 Protects Cardiomyocytes from lipopolysaccharide-Induced Mitochondrial Damage by Reducing Lactate Accumulation
Tangtian Chen, Qiumin Xie, Bin Tan, Qin Yi, Han Xiang, Rui Wang, Qin Zhou, Bolin He, Jie Tian, Jing Zhu, Hao Xu
Inflammation.2024; 47(4): 1356. CrossRef
Effect of resistance training plus enriched probiotic supplement on sestrin2, oxidative stress, and mitophagy markers in elderly male Wistar rats
Majid Mohabbat, Hamid Arazi
Scientific Reports.2024;[Epub] CrossRef
Comparison between single-muscle evaluation and cross-sectional area muscle evaluation for predicting the prognosis in patients with oral squamous cell carcinoma: a retrospective cohort study
Hirotaka Takayama, Takuya Yoshimura, Hajime Suzuki, Yuka Hirano, Masahiro Tezuka, Takayuki Ishida, Kiyohide Ishihata, Marie Amitani, Haruka Amitani, Yasunori Nakamura, Yasushi Imamura, Akio Inui, Norifumi Nakamura
Frontiers in Oncology.2024;[Epub] CrossRef
Resveratrol and Vitamin D: Eclectic Molecules Promoting Mitochondrial Health in Sarcopenia
Cristina Russo, Maria Stella Valle, Floriana D’Angeli, Sofia Surdo, Lucia Malaguarnera
International Journal of Molecular Sciences.2024; 25(14): 7503. CrossRef
Unveiling the crucial role of peroxisomal acyl-CoA metabolism in muscle atrophy: Insights from genetic models and therapeutic interventions
Songling Jiang, Han Sol Kim, Ji Hyun Ryu, Yong-Soo Lee, Dong-Ik Kim, Eun-Jung Jin
Nano Today.2024; 58: 102417. CrossRef
Dichloroacetate Prevents Sepsis Associated Encephalopathy by Inhibiting Microglia Pyroptosis through PDK4/NLRP3
Xuliang Huang, Yuhao Zheng, Nan Wang, Mingming Zhao, Jinhui Liu, Wen Lin, Ye Zhu, Xiaofan Xie, Ya Lv, Junlu Wang, Yunchang Mo
Inflammation.2024; 48(3): 1159. CrossRef
The MyoGravity project to study real microgravity effects on human muscle precursor cells and tissue
Ester Sara Di Filippo, Sara Chiappalupi, Stefano Falone, Vincenza Dolo, Fernanda Amicarelli, Silvia Marchianò, Adriana Carino, Gabriele Mascetti, Giovanni Valentini, Sara Piccirillo, Michele Balsamo, Marco Vukich, Stefano Fiorucci, Guglielmo Sorci, Stefan
npj Microgravity.2024;[Epub] CrossRef
Mitochondria in skeletal system-related diseases
Liang Pei, Zhuo Yao, Dong Liang, Keda Yang, Lin Tao
Biomedicine & Pharmacotherapy.2024; 181: 117505. CrossRef
Incretin-Based Therapies: A Promising Approach for Modulating Oxidative Stress and Insulin Resistance in Sarcopenia
Raniah I. Alnaser, Fawaz A. Alassaf, Mohammed N. Abed
Journal of Bone Metabolism.2024; 31(4): 251. CrossRef
Sodium Phenylbutyrate Attenuates Cisplatin-Induced Acute Kidney Injury Through Inhibition of Pyruvate Dehydrogenase Kinase 4
Chang Joo Oh, Wooyoung Choi, Ha Young Lee, In-Kyu Lee, Min-Ji Kim, Jae-Han Jeon
Biomedicines.2024; 12(12): 2815. CrossRef
Neuroprotective Effects and Therapeutic Potential of Dichloroacetate: Targeting Metabolic Disorders in Nervous System Diseases
Yue Zhang, Meiyan Sun, Hongxiang Zhao, Zhengyan Wang, Yanan Shi, Jianxin Dong, Kaifang Wang, Xi Wang, Xingyue Li, Haiyan Qi, Xiaoyong Zhao
International Journal of Nanomedicine.2023; Volume 18: 7559. CrossRef

Letter

Letter: Presence of Carotid Plaque Is Associated with Rapid Renal Function Decline in Patients with Type 2 Diabetes Mellitus and Normal Renal Function (Diabetes Metab J 2019;43:840–53): Min-Ji Kim, Jae-Han Jeon; Diabetes Metab J. 2020;44(1):201-202. Published online February 21, 2020; DOI: https://doi.org/10.4093/dmj.2020.0017

5,013 View
47 Download

PDF PubReader ePub

First
Prev
Page of 1
Next
Last

Search