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Original Article
- Metabolic Risk/Epidemiology
- Temporal Changes in Resting Heart Rate and Risk of Diabetes Mellitus
- Mi Kyoung Son, Kyoungho Lee, Hyun-Young Park
- Diabetes Metab J. 2024;48(4):752-762. Published online February 2, 2024
- DOI: https://doi.org/10.4093/dmj.2023.0305
- 5,885 View
- 219 Download
- 1 Web of Science
- 1 Crossref
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Abstract
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Supplementary Material
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ePub - Background
To investigate the association between the time-varying resting heart rate (RHR) and change in RHR (∆RHR) over time and the risk of diabetes mellitus (DM) by sex.
Methods
We assessed 8,392 participants without DM or atrial fibrillation/flutter from the Korean Genome and Epidemiology Study, a community-based prospective cohort study that was initiated in 2001 to 2002. The participants were followed up until December 31, 2018. Updating RHR with biennial in-study re-examinations, the time-varying ∆RHR was calculated by assessing the ∆RHR at the next follow-up visit.
Results
Over a median follow-up of 12.3 years, 1,345 participants (16.2%) had DM. As compared with RHR of 60 to 69 bpm, for RHR of ≥80 bpm, the incidence of DM was significantly increased for both male and female. A drop of ≥5 bpm in ∆RHR when compared with the stable ∆RHR group (–5< ∆RHR <5 bpm) was associated significantly with lower risk of DM in both male and female. However, an increase of ≥5 bpm in ∆RHR was significantly associated with higher risk of DM only in female, not in male (hazard ratio for male, 1.057 [95% confidence interval, 0.869 to 1.285]; and for female, 1.218 [95% confidence interval, 1.008 to 1.471]).
Conclusion
In this community-based longitudinal cohort study, a reduction in ∆RHR was associated with a decreased risk of DM, while an increase in ∆RHR was associated with an increased risk of DM only in female. -
Citations
Citations to this article as recorded by
- Unstable resting heart rate trajectory patterns are associated with an increase in incident risk of type 2 diabetes mellitus: the China-PAR project
Yuying Wu, Yang Zhao, Yanyan Zhang, Xueru Fu, Liuding Wen, Weifeng Huo, Jianxin Li, Xiangfeng Lu, Fulan Hu, Dongsheng Hu, Ming Zhang
Journal of Epidemiology and Community Health.2025; 79(10): 758. CrossRef
- Unstable resting heart rate trajectory patterns are associated with an increase in incident risk of type 2 diabetes mellitus: the China-PAR project
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