Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
1 "Mark E. Pepin"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Review
Complications
My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy
Manoja K. Brahma, Mark E. Pepin, Adam R. Wende
Diabetes Metab J. 2017;41(1):1-9.   Published online November 15, 2016
DOI: https://doi.org/10.4093/dmj.2017.41.1.1
  • 4,687 View
  • 79 Download
  • 42 Web of Science
  • 39 Crossref
AbstractAbstract PDFPubReader   

Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level and uptake contribute to cardiovascular disease (CVD) by modifying proteins, DNA, and gene expression. In the case of glucose, clinical studies have shown that increased dietary sugars for healthy individuals or poor glycemic control in diabetic patients further increased CVD risk. Furthermore, even after decades of maintaining tight glycemic control, susceptibility to disease progression can persist following a period of poor glycemic control through a process termed "glycemic memory." In response to chronically elevated glucose levels, a number of studies have identified molecular targets of the glucose-mediated protein posttranslational modification by the addition of an O-linked N-acetylglucosamine to impair contractility, calcium sensitivity, and mitochondrial protein function. Additionally, elevated glucose contributes to dysfunction in coupling glycolysis to glucose oxidation, pentose phosphate pathway, and polyol pathway. Therefore, in the "sweetened" environment associated with hyperglycemia, there are a number of pathways contributing to increased susceptibly to "breaking" the heart of diabetics. In this review we will discuss the unique contribution of glucose to heart disease and recent advances in defining mechanisms of action.

Citations

Citations to this article as recorded by  
  • Compound SJ-12 attenuates streptozocin-induced diabetic cardiomyopathy by stabilizing SERCA2a
    Shuaijie Lou, Weiwei Zhu, Tianxiang Yu, Qianhui Zhang, Minxiu Wang, Leiming Jin, Yongqiang Xiong, Jiachen Xu, Qinyan Wang, Gaozhi Chen, Guang Liang, Xiang Hu, Wu Luo
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2024; 1870(5): 167140.     CrossRef
  • O304 ameliorates hyperglycemia in mice by dually promoting muscle glucose effectiveness and preserving β-cell function
    Stefan Norlin, Jan Axelsson, Madelene Ericsson, Helena Edlund
    Communications Biology.2023;[Epub]     CrossRef
  • The role of glycolytic metabolic pathways in cardiovascular disease and potential therapeutic approaches
    Shuxian Chen, Yuanming Zou, Chunyu Song, Kexin Cao, Kexin Cai, Yanjiao Wu, Zhaobo Zhang, Danxi Geng, Wei Sun, Nanxiang Ouyang, Naijin Zhang, Zhao Li, Guozhe Sun, Yixiao Zhang, Yingxian Sun, Ying Zhang
    Basic Research in Cardiology.2023;[Epub]     CrossRef
  • Silibinin ameliorates the cardiovascular oxidative and inflammatory effects of type-2-diabetic rats exposed to air particulate matter
    Olamide O. Awolaja, Akeem O. Lawal, Ibukun M. Folorunso, Olusola O. Elekofehinti, Haruna I. Umar
    Polycyclic Aromatic Compounds.2023; 43(7): 6570.     CrossRef
  • The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK
    Jozaa Z. AlTamimi, Nora A. AlFaris, Ghedeir M. Alshammari, Reham I. Alagal, Dalal H. Aljabryn, Mohammed Abdo Yahya
    Nutrients.2023; 15(7): 1660.     CrossRef
  • The role of CD36 in cardiovascular disease
    Hongyang Shu, Yizhong Peng, Weijian Hang, Jiali Nie, Ning Zhou, Dao Wen Wang
    Cardiovascular Research.2022; 118(1): 115.     CrossRef
  • The world congress on insulin resistance, diabetes, and cardiovascular disease (WCIRDC)
    Zachary Bloomgarden
    Journal of Diabetes.2022; 14(3): 163.     CrossRef
  • Pharmacological modulation of prostaglandin E2 (PGE2) EP receptors improves cardiomyocyte function under hyperglycemic conditions
    Karin J. Bosma, Monica Ghosh, Spencer R. Andrei, Lin Zhong, Jennifer C. Dunn, Valerie F. Ricciardi, Juliann B. Burkett, Antonis K. Hatzopoulos, Derek S. Damron, Maureen Gannon
    Physiological Reports.2022;[Epub]     CrossRef
  • The efficacy and safety of traditional Chinese medicine treating diabetic cardiomyopathy: A protocol for systematic review and meta-analysis
    Shuo Han, Yuan Hou, Huaman Liu, Quanlin Zhao
    Medicine.2022; 101(47): e31269.     CrossRef
  • High Throughput Screen Identifies Small Molecule Effectors That Modulate Thin Filament Activation in Cardiac Muscle
    Priyanka Parijat, Laszlo Kondacs, Alexander Alexandrovich, Mathias Gautel, Alexander J. A. Cobb, Thomas Kampourakis
    ACS Chemical Biology.2021; 16(1): 225.     CrossRef
  • Prostaglandin E receptor subtype 4 protects against diabetic cardiomyopathy by modulating cardiac fatty acid metabolism via FOXO1/CD36 signalling
    Fan Ying, Hao Liu, Eva Hoi Ching Tang, Ishan Lakhani, Ningning Liu, Zhengyuan Xia, Shiming Liu
    Biochemical and Biophysical Research Communications.2021; 548: 196.     CrossRef
  • Intracellular Toxic AGEs (TAGE) Triggers Numerous Types of Cell Damage
    Masayoshi Takeuchi, Akiko Sakasai-Sakai, Takanobu Takata, Jun-ichi Takino, Yoshiki Koriyama, Chigusa Kikuchi, Ayako Furukawa, Kentaro Nagamine, Takamitsu Hori, Tamihide Matsunaga
    Biomolecules.2021; 11(3): 387.     CrossRef
  • Phosphorylated and O-GlcNAc Modified IRS-1 (Ser1101) and -2 (Ser1149) Contribute to Human Diabetes Type II
    Afshan Kaleem, Sabahat Javed, Nayab Rehman, Roheena Abdullah, Mehwish Iqtedar, Mohammad Nauman Aftab, Daniel C. Hoessli, Ikram-Ul Haq
    Protein & Peptide Letters.2021; 28(3): 333.     CrossRef
  • Diabetes and Heart Failure: Multi-Omics Approaches
    Akram Tayanloo-Beik, Peyvand Parhizkar Roudsari, Mostafa Rezaei-Tavirani, Mahmood Biglar, Ozra Tabatabaei-Malazy, Babak Arjmand, Bagher Larijani
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • Asymptomatic Diabetic Cardiomyopathy: an Underrecognized Entity in Type 2 Diabetes
    Ana Maria Stanton, Muthiah Vaduganathan, Lee-Shing Chang, Alexander Turchin, James L. Januzzi, Vanita R. Aroda
    Current Diabetes Reports.2021;[Epub]     CrossRef
  • Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization
    Manoja K. Brahma, Chae‐Myeong Ha, Mark E. Pepin, Sobuj Mia, Zhihuan Sun, John C. Chatham, Kirk M. Habegger, Evan Dale Abel, Andrew J. Paterson, Martin E. Young, Adam R. Wende
    Journal of the American Heart Association.2020;[Epub]     CrossRef
  • Gene therapy targeting cardiac phosphoinositide 3-kinase (p110α) attenuates cardiac remodeling in type 2 diabetes
    Darnel Prakoso, Miles J. De Blasio, Mitchel Tate, Helen Kiriazis, Daniel G. Donner, Hongwei Qian, David Nash, Minh Deo, Kate L. Weeks, Laura J. Parry, Paul Gregorevic, Julie R. McMullen, Rebecca Helen Ritchie
    American Journal of Physiology-Heart and Circulatory Physiology.2020; 318(4): H840.     CrossRef
  • The Potential Role of MicroRNA in Diabetic Cardiomyopathy
    Jin Hwa Kim
    Diabetes & Metabolism Journal.2020; 44(1): 54.     CrossRef
  • Re-balancing cellular energy substrate metabolism to mend the failing heart
    Jan F.C. Glatz, Miranda Nabben, Martin E. Young, P. Christian Schulze, Heinrich Taegtmeyer, Joost J.F.P. Luiken
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2020; 1866(5): 165579.     CrossRef
  • The Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1α–Heme Oxygenase 1 Axis, a Powerful Antioxidative Pathway with Potential to Attenuate Diabetic Cardiomyopathy
    Maayan Waldman, Michael Arad, Nader G. Abraham, Edith Hochhauser
    Antioxidants & Redox Signaling.2020; 32(17): 1273.     CrossRef
  • miR‑155 modulates high glucose‑induced cardiac fibrosis via the Nrf2/HO‑1 signaling pathway
    Yu Li, Jing‑Zhu Duan, Qian He, Chong‑Quan Wang
    Molecular Medicine Reports.2020;[Epub]     CrossRef
  • Disruption of energy utilization in diabetic cardiomyopathy; a mini review
    Shinsuke Nirengi, Carmem Peres Valgas da Silva, Kristin I Stanford
    Current Opinion in Pharmacology.2020; 54: 82.     CrossRef
  • Reduced fatty acid uptake aggravates cardiac contractile dysfunction in streptozotocin-induced diabetic cardiomyopathy
    Yogi Umbarawan, Ryo Kawakami, Mas Rizky A. A. Syamsunarno, Norimichi Koitabashi, Hideru Obinata, Aiko Yamaguchi, Hirofumi Hanaoka, Takako Hishiki, Noriyo Hayakawa, Hiroaki Sunaga, Hiroki Matsui, Masahiko Kurabayashi, Tatsuya Iso
    Scientific Reports.2020;[Epub]     CrossRef
  • Metabolomics biomarkers and the risk of overall mortality and ESRD in CKD: Results from the Progredir Cohort
    Silvia M. Titan, Gabriela Venturini, Kallyandra Padilha, Alessandra C. Goulart, Paulo A. Lotufo, Isabela J. Bensenor, Jose E. Krieger, Ravi I. Thadhani, Eugene P. Rhee, Alexandre C. Pereira, Vivekanand Jha
    PLOS ONE.2019; 14(3): e0213764.     CrossRef
  • Chronic hyperglycemia as a risk factor in implant therapy
    Fawad Javed, Georgios E. Romanos
    Periodontology 2000.2019; 81(1): 57.     CrossRef
  • Recent advances in the pathogenesis of microvascular complications in diabetes
    Sungmi Park, Hyeon-Ji Kang, Jae-Han Jeon, Min-Ji Kim, In-Kyu Lee
    Archives of Pharmacal Research.2019; 42(3): 252.     CrossRef
  • Nutrient regulation of signaling and transcription
    Gerald W. Hart
    Journal of Biological Chemistry.2019; 294(7): 2211.     CrossRef
  • Intracellular toxic advanced glycation end-products in cardiomyocytes may cause cardiovascular disease
    Takanobu Takata, Akiko Sakasai-Sakai, Tadashi Ueda, Masayoshi Takeuchi
    Scientific Reports.2019;[Epub]     CrossRef
  • Effects of Exercise to Improve Cardiovascular Health
    Kelsey Pinckard, Kedryn K. Baskin, Kristin I. Stanford
    Frontiers in Cardiovascular Medicine.2019;[Epub]     CrossRef
  • A new hyperpolarized 13C ketone body probe reveals an increase in acetoacetate utilization in the diabetic rat heart
    Desiree Abdurrachim, Chern Chiuh Woo, Xing Qi Teo, Wei Xin Chan, George K. Radda, Philip Teck Hock Lee
    Scientific Reports.2019;[Epub]     CrossRef
  • Chronic O-GlcNAcylation and Diabetic Cardiomyopathy: The Bitterness of Glucose
    Simon Ducheix, Jocelyne Magré, Bertrand Cariou, Xavier Prieur
    Frontiers in Endocrinology.2018;[Epub]     CrossRef
  • Proteomics of the Rat Myocardium during Development of Type 2 Diabetes Mellitus Reveals Progressive Alterations in Major Metabolic Pathways
    Anders Valdemar Edhager, Jonas Agerlund Povlsen, Bo Løfgren, Hans Erik Bøtker, Johan Palmfeldt
    Journal of Proteome Research.2018; 17(7): 2521.     CrossRef
  • Protective effects of astaxanthin on diabetic cardiomyopathy in rats
    Bingshan Zhang, Di Xu
    CyTA - Journal of Food.2018; 16(1): 909.     CrossRef
  • Au cœur de la cardiomyopathie diabétique
    Alexandre Lugat, Michael Joubert, Bertrand Cariou, Xavier Prieur
    médecine/sciences.2018; 34(6-7): 563.     CrossRef
  • Redox imbalance stress in diabetes mellitus: Role of the polyol pathway
    Liang‐jun Yan
    Animal Models and Experimental Medicine.2018; 1(1): 7.     CrossRef
  • Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
    Othmar Moser, Max L. Eckstein, Olivia McCarthy, Rachel Deere, Stephen C. Bain, Hanne L. Haahr, Eric Zijlstra, Tim Heise, Richard M. Bracken, Petter Bjornstad
    PLOS ONE.2018; 13(4): e0194750.     CrossRef
  • Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts
    Tae Hee Ko, Jubert C. Marquez, Hyoung Kyu Kim, Seung Hun Jeong, SungRyul Lee, Jae Boum Youm, In Sung Song, Dae Yun Seo, Hye Jin Kim, Du Nam Won, Kyoung Im Cho, Mun Gi Choi, Byoung Doo Rhee, Kyung Soo Ko, Nari Kim, Jong Chul Won, Jin Han
    Pflügers Archiv - European Journal of Physiology.2018; 470(2): 263.     CrossRef
  • Adriamycin-induced cardiomyopathy can serve as a model for diabetic cardiomyopathy – a hypothesis
    Kaviyarasi Renu, V.G. Abilash, P.B. Tirupathi Pichiah, Thabassum Akthar Syeda, Sankarganesh Arunachalam
    Asian Pacific Journal of Tropical Biomedicine.2017; 7(11): 1041.     CrossRef
  • Proteome profiling in the aorta and kidney of type 1 diabetic rats
    Moustafa Al Hariri, Mohamad Elmedawar, Rui Zhu, Miran A. Jaffa, Jingfu Zhao, Parvin Mirzaei, Adnan Ahmed, Firas Kobeissy, Fuad N. Ziyadeh, Yehia Mechref, Ayad A. Jaffa, Michael Bader
    PLOS ONE.2017; 12(11): e0187752.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal