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Original Article
Basic Research
Inhibition of Ceramide Accumulation in Podocytes by Myriocin Prevents Diabetic Nephropathy
Chang-Yun Woo, Ji Yeon Baek, Ah-Ram Kim, Chung Hwan Hong, Ji Eun Yoon, Hyoun Sik Kim, Hyun Ju Yoo, Tae-Sik Park, Ranjan Kc, Ki-Up Lee, Eun Hee Koh
Diabetes Metab J. 2020;44(4):581-591.   Published online November 4, 2019
DOI: https://doi.org/10.4093/dmj.2019.0063
  • 5,887 View
  • 161 Download
  • 24 Web of Science
  • 29 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

Ceramides are associated with metabolic complications including diabetic nephropathy in patients with diabetes. Recent studies have reported that podocytes play a pivotal role in the progression of diabetic nephropathy. Also, mitochondrial dysfunction is known to be an early event in podocyte injury. Thus, we tested the hypothesis that ceramide accumulation in podocytes induces mitochondrial damage through reactive oxygen species (ROS) production in patients with diabetic nephropathy.

Methods

We used Otsuka Long Evans Tokushima Fatty (OLETF) rats and high-fat diet (HFD)-fed mice. We fed the animals either a control- or a myriocin-containing diet to evaluate the effects of the ceramide. Also, we assessed the effects of ceramide on intracellular ROS generation and on podocyte autophagy in cultured podocytes.

Results

OLETF rats and HFD-fed mice showed albuminuria, histologic features of diabetic nephropathy, and podocyte injury, whereas myriocin treatment effectively treated these abnormalities. Cultured podocytes exposed to agents predicted to be risk factors (high glucose, high free fatty acid, and angiotensin II in combination [GFA]) showed an increase in ceramide accumulation and ROS generation in podocyte mitochondria. Pretreatment with myriocin reversed GFA-induced mitochondrial ROS generation and prevented cell death. Myriocin-pretreated cells were protected from GFA-induced disruption of mitochondrial integrity.

Conclusion

We showed that mitochondrial ceramide accumulation may result in podocyte damage through ROS production. Therefore, this signaling pathway could become a pharmacological target to abate the development of diabetic kidney disease.

Citations

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Sulwon Lecture 2018
Pathophysiology
Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation
Chang-Yun Woo, Jung Eun Jang, Seung Eun Lee, Eun Hee Koh, Ki-Up Lee
Diabetes Metab J. 2019;43(3):247-256.   Published online March 27, 2019
DOI: https://doi.org/10.4093/dmj.2018.0221
  • 8,123 View
  • 251 Download
  • 67 Web of Science
  • 69 Crossref
AbstractAbstract PDFPubReader   

Adipose tissue inflammation is considered a major contributing factor in the development of obesity-associated insulin resistance and cardiovascular diseases. However, the cause of adipose tissue inflammation is presently unclear. The role of mitochondria in white adipocytes has long been neglected because of their low abundance. However, recent evidence suggests that mitochondria are essential for maintaining metabolic homeostasis in white adipocytes. In a series of recent studies, we found that mitochondrial function in white adipocytes is essential to the synthesis of adiponectin, which is the most abundant adipokine synthesized from adipocytes, with many favorable effects on metabolism, including improvement of insulin sensitivity and reduction of atherosclerotic processes and systemic inflammation. From these results, we propose a new hypothesis that mitochondrial dysfunction in adipocytes is a primary cause of adipose tissue inflammation and compared this hypothesis with a prevailing concept that “adipose tissue hypoxia” may underlie adipose tissue dysfunction in obesity. Recent studies have emphasized the role of the mitochondrial quality control mechanism in maintaining mitochondrial function. Future studies are warranted to test whether an inadequate mitochondrial quality control mechanism is responsible for mitochondrial dysfunction in adipocytes and adipose tissue inflammation.

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Review
Clinical Diabetes & Therapeutics
Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis
Seung-Hyun Ko, Kyungdo Han, Yong-ho Lee, Junghyun Noh, Cheol-Young Park, Dae-Jung Kim, Chang Hee Jung, Ki-Up Lee, Kyung-Soo Ko
Diabetes Metab J. 2018;42(2):93-100.   Published online April 19, 2018
DOI: https://doi.org/10.4093/dmj.2018.42.2.93
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AbstractAbstract PDFPubReader   

Korea's National Healthcare Program, the National Health Insurance Service (NHIS), a government-affiliated agency under the Korean Ministry of Health and Welfare, covers the entire Korean population. The NHIS supervises all medical services in Korea and establishes a systematic National Health Information database (DB). A health information DB system including all of the claims, medications, death information, and health check-ups, both in the general population and in patients with various diseases, is not common worldwide. On June 9, 2014, the NHIS signed a memorandum of understanding with the Korean Diabetes Association (KDA) to provide limited open access to its DB. By October 31, 2017, seven papers had been published through this collaborative research project. These studies were conducted to investigate the past and current status of type 2 diabetes mellitus and its complications and management in Korea. This review is a brief summary of the collaborative projects between the KDA and the NHIS over the last 3 years. According to the analysis, the national health check-up DB or claim DB were used, and the age category or study period were differentially applied.

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Original Article
Obesity and Metabolic Syndrome
Statins Increase Mitochondrial and Peroxisomal Fatty Acid Oxidation in the Liver and Prevent Non-Alcoholic Steatohepatitis in Mice
Han-Sol Park, Jung Eun Jang, Myoung Seok Ko, Sung Hoon Woo, Bum Joong Kim, Hyun Sik Kim, Hye Sun Park, In-Sun Park, Eun Hee Koh, Ki-Up Lee
Diabetes Metab J. 2016;40(5):376-385.   Published online April 5, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.5.376
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AbstractAbstract PDFPubReader   
Background

Non-alcoholic fatty liver disease is the most common form of chronic liver disease in industrialized countries. Recent studies have highlighted the association between peroxisomal dysfunction and hepatic steatosis. Peroxisomes are intracellular organelles that contribute to several crucial metabolic processes, such as facilitation of mitochondrial fatty acid oxidation (FAO) and removal of reactive oxygen species through catalase or plasmalogen synthesis. Statins are known to prevent hepatic steatosis and non-alcoholic steatohepatitis (NASH), but underlying mechanisms of this prevention are largely unknown.

Methods

Seven-week-old C57BL/6J mice were given normal chow or a methionine- and choline-deficient diet (MCDD) with or without various statins, fluvastatin, pravastatin, simvastatin, atorvastatin, and rosuvastatin (15 mg/kg/day), for 6 weeks. Histological lesions were analyzed by grading and staging systems of NASH. We also measured mitochondrial and peroxisomal FAO in the liver.

Results

Statin treatment prevented the development of MCDD-induced NASH. Both steatosis and inflammation or fibrosis grades were significantly improved by statins compared with MCDD-fed mice. Gene expression levels of peroxisomal proliferator-activated receptor α (PPARα) were decreased by MCDD and recovered by statin treatment. MCDD-induced suppression of mitochondrial and peroxisomal FAO was restored by statins. Each statin's effect on increasing FAO and improving NASH was independent on its effect of decreasing cholesterol levels.

Conclusion

Statins prevented NASH and increased mitochondrial and peroxisomal FAO via induction of PPARα. The ability to increase hepatic FAO is likely the major determinant of NASH prevention by statins. Improvement of peroxisomal function by statins may contribute to the prevention of NASH.

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Brief Report
Epidemiology
Data Analytic Process of a Nationwide Population-Based Study Using National Health Information Database Established by National Health Insurance Service
Yong-ho Lee, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko, Ki-Up Lee
Diabetes Metab J. 2016;40(1):79-82.   Published online February 19, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.79
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AbstractAbstract PDFPubReader   

In 2014, the National Health Insurance Service (NHIS) signed a memorandum of understanding with the Korean Diabetes Association to provide limited open access to its databases for investigating the past and current status of diabetes and its management. NHIS databases include the entire Korean population; therefore, it can be used as a population-based nationwide study for various diseases, including diabetes and its complications. This report presents how we established the analytic system of nation-wide population-based studies using the NHIS database as follows: the selection of database study population and its distribution and operational definition of diabetes and patients of currently ongoing collaboration projects.

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Original Articles
Complications
Serum Total Bilirubin Levels Provide Additive Risk Information over the Framingham Risk Score for Identifying Asymptomatic Diabetic Patients at Higher Risk for Coronary Artery Stenosis
Jaechan Leem, Eun Hee Koh, Jung Eun Jang, Chang-Yun Woo, Jin Sun Oh, Min Jung Lee, Joon-Won Kang, Tae-Hwan Lim, Chang Hee Jung, Woo Je Lee, Joong-Yeol Park, Ki-Up Lee
Diabetes Metab J. 2015;39(5):414-423.   Published online October 22, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.5.414
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AbstractAbstract PDFPubReader   
Background

The diagnosis of coronary artery disease (CAD) is often delayed in patients with type 2 diabetes. Serum total bilirubin levels are inversely associated with CAD. However, no studies have examined whether this can be used as a biochemical marker for identifying asymptomatic diabetic patients at higher risk for having obstructive CAD.

Methods

We performed a cross-sectional study of 460 consecutive asymptomatic patients with type 2 diabetes. All patients underwent coronary computed tomographic angiography, and their serum total bilirubin levels were measured. Obstructive CAD was defined as ≥50% diameter stenosis in at least one coronary artery.

Results

Serum total bilirubin tertiles showed an inverse association with the prevalence of obstructive CAD. In multivariate logistic regression analysis, the odds ratio for the highest versus the lowest tertile of total bilirubin was 0.227 (95% confidence interval [CI], 0.130 to 0.398), and an increment of 1 µmol/L in serum total bilirubin level was associated with a 14.6% decrease in obstructive CAD after adjustment for confounding variables. Receiver operating characteristic curve analysis showed that the area under the curve for the Framingham Risk Score (FRS) plus serum total bilirubin level was 0.712 (95% CI, 0.668 to 0.753), which is significantly greater than that of the FRS alone (P=0.0028).

Conclusion

Serum total bilirubin level is inversely associated with obstructive CAD and provides additive risk information over the FRS. Serum total bilirubin may be helpful for identifying asymptomatic patients with type 2 diabetes who are at higher risk for obstructive CAD.

Citations

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Clinical Features and Causes of Endogenous Hyperinsulinemic Hypoglycemia in Korea
Chang-Yun Woo, Ji Yun Jeong, Jung Eun Jang, Jaechan Leem, Chang Hee Jung, Eun Hee Koh, Woo Je Lee, Min-Seon Kim, Joong-Yeol Park, Jung Bok Lee, Ki-Up Lee
Diabetes Metab J. 2015;39(2):126-131.   Published online March 9, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.2.126
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AbstractAbstract PDFPubReader   
Background

Endogenous hyperinsulinemic hypoglycemia (EHH) is characterized by an inappropriately high plasma insulin level, despite a low plasma glucose level. Most of the EHH cases are caused by insulinoma, whereas nesidioblastosis and insulin autoimmune syndrome (IAS) are relatively rare.

Methods

To evaluate the relative frequencies of various causes of EHH in Korea, we retrospectively analyzed 84 patients who were diagnosed with EHH from 1998 to 2012 in a university hospital.

Results

Among the 84 EHH patients, 74 patients (88%), five (6%), and five (6%) were diagnosed with insulinoma, nesidioblastosis or IAS, respectively. The most common clinical manifestation of EHH was neuroglycopenic symptoms. Symptom duration before diagnosis was 14.5 months (range, 1 to 120 months) for insulinoma, 1.0 months (range, 6 days to 7 months) for nesidioblastosis, and 2.0 months (range, 1 to 12 months) for IAS. One patient, who was diagnosed with nesidioblastosis in 2006, underwent distal pancreatectomy but was later determined to be positive for insulin autoantibodies. Except for one patient who was diagnosed in 2007, the remaining three patients with nesidioblastosis demonstrated severe hyperinsulinemia (157 to 2,719 µIU/mL), which suggests that these patients might have had IAS, rather than nesidioblastosis.

Conclusion

The results of this study suggest that the prevalence of IAS may be higher in Korea than previously thought. Therefore, measurement of insulin autoantibody levels is warranted for EHH patients, especially in patients with very high plasma insulin levels.

Citations

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Background and Data Configuration Process of a Nationwide Population-Based Study Using the Korean National Health Insurance System
Sun Ok Song, Chang Hee Jung, Young Duk Song, Cheol-Young Park, Hyuk-Sang Kwon, Bong Soo Cha, Joong-Yeol Park, Ki-Up Lee, Kyung Soo Ko, Byung-Wan Lee
Diabetes Metab J. 2014;38(5):395-403.   Published online October 17, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.5.395
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AbstractAbstract PDFPubReader   
Background

The National Health Insurance Service (NHIS) recently signed an agreement to provide limited open access to the databases within the Korean Diabetes Association for the benefit of Korean subjects with diabetes. Here, we present the history, structure, contents, and way to use data procurement in the Korean National Health Insurance (NHI) system for the benefit of Korean researchers.

Methods

The NHIS in Korea is a single-payer program and is mandatory for all residents in Korea. The three main healthcare programs of the NHI, Medical Aid, and long-term care insurance (LTCI) provide 100% coverage for the Korean population. The NHIS in Korea has adopted a fee-for-service system to pay health providers. Researchers can obtain health information from the four databases of the insured that contain data on health insurance claims, health check-ups and LTCI.

Results

Metabolic disease as chronic disease is increasing with aging society. NHIS data is based on mandatory, serial population data, so, this might show the time course of disease and predict some disease progress, and also be used in primary and secondary prevention of disease after data mining.

Conclusion

The NHIS database represents the entire Korean population and can be used as a population-based database. The integrated information technology of the NHIS database makes it a world-leading population-based epidemiology and disease research platform.

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  • A population-based study on the risk of prescription opioid abuse in patients with chronic opioid use and cost-effectiveness of prescription drug monitoring program using a patient simulation model in South Korea
    Siin Kim, Hae Sun Suh
    International Journal of Drug Policy.2023; 112: 103953.     CrossRef
  • The effects of sociodemographic factors on help-seeking for depression: Based on the 2017–2020 Korean Community Health Survey
    JinYoung Lee, Kyeong-Sook Choi, Ji-Ae Yun, Pedro Vieira da Silva Magalhaes
    PLOS ONE.2023; 18(1): e0280642.     CrossRef
  • Efficacy of acupuncture on cardiovascular complications in patients with diabetes mellitus in Korea: A nationwide retrospective cohort
    Hyejin Jung, Tiana Won, Ga-Yeon Kim, Jowon Jang, Sujung Yeo, Sabina Lim
    Journal of Integrative Medicine.2023; 21(2): 176.     CrossRef
  • A 12-year nationwide cohort study on the association between central retinal artery occlusion and cancer
    Min Seok Kim, Seong Jun Byun, Se Joon Woo, Kyu Hyung Park, Sang Jun Park
    Graefe's Archive for Clinical and Experimental Ophthalmology.2023;[Epub]     CrossRef
  • Long-Term Nonoperative Management is Associated With Lower Mean 9-Year Follow-Up Survival Compared to Total Knee Arthroplasty in Knee Osteoarthritis Patients—Survival Analysis of a Nationwide South Korean Cohort
    Hyein Han, Du Hyun Ro, Sungho Won, Hyuk-Soo Han
    The Journal of Arthroplasty.2023; 38(8): 1470.     CrossRef
  • Positive faecal immunochemical test predicts the onset of inflammatory bowel disease: A nationwide, propensity score-matched study
    Eunyoung Lee, Gil Ho Lee, Bumhee Park, Sung Soo Ahn, Choong-Kyun Noh
    Frontiers in Immunology.2023;[Epub]     CrossRef
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    Amar Lokman, R. Kanesaraj Ramasamy, Choo-Yee Ting
    IEEE Access.2023; 11: 17983.     CrossRef
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    Daniel Duck-Jin Hwang, Kyung-Eun Lee, Yuwon Kim, Myoung-Suk Kim, Tyler Hyungtaek Rim, Mina Kim, Hasung Kim, Dae-Sung Kyoung, Ji In Park
    JAMA Network Open.2023; 6(3): e233068.     CrossRef
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    Suk Ho Sohn, Yoonjin Kang, Ji Seong Kim, Ho Young Hwang, Kyung Hwan Kim, Jae Woong Choi
    The Journal of Thoracic and Cardiovascular Surgery.2023;[Epub]     CrossRef
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    Dojoon Park, Yong-Moon Park, Seung-Hyun Ko, Kang-Se Hyun, Youn-Ho Choi, Dong-Uk Min, Kyungdo Han, Hae-Seok Koh
    Scientific Reports.2023;[Epub]     CrossRef
  • Prior Lifestyle and Survival Outcomes After Intensive Care Unit Admission
    In-Ae Song, Tak Kyu Oh
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
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    Bokyung Kim, Jin-Hyung Jung, Kyungdo Han, Seungkyung Kang, Eunwoo Lee, Hyunsoo Chung, Sang Gyun Kim, Soo-Jeong Cho
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    Mi Hee Cho, Kyungdo Han, Seungwoo Lee, Su-Min Jeong, Jung Eun Yoo, SangYun Kim, Jinkook Lee, Sohyun Chun, Dong Wook Shin
    Alzheimer's Research & Therapy.2023;[Epub]     CrossRef
  • Increased risk of cardiovascular disease associated with diabetes among adult cancer survivors: a population-based matched cohort study
    Sanghyun Oh, Jihwan Lee, Yoo S Hong, Kyuwoong Kim
    European Journal of Preventive Cardiology.2023;[Epub]     CrossRef
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    Jae Young Kim, Sung-youn Chun, Hyunsun Lim, Tae Ik Chang
    Scientific Reports.2023;[Epub]     CrossRef
  • Participation and Prognostic Impact of Cardiac Rehabilitation After Acute Coronary Syndrome: Big-Data Study of the Korean National Health Insurance Service
    Hee-Eun Choi, Chul Kim, Da-Jung Lee, Jae-Eun Joo, Ho-Seob Kim
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
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    Juncheol Lee, Yongil Cho, Jaehoon Oh, Hyunggoo Kang, Tae Ho Lim, Byuk Sung Ko, Kyung Hun Yoo, Sang Hwan Lee
    JAMA Network Open.2023; 6(4): e237809.     CrossRef
  • Treatment Changes and Prognoses in Patients with Incident Drug-Induced Parkinsonism Using a Korean Nationwide Healthcare Claims Database
    Siin Kim, Hae Sun Suh
    Journal of Clinical Medicine.2023; 12(8): 2860.     CrossRef
  • Trends in the Incidence and Etiology of Non-Traumatic Spinal Cord Injury in Korea: A Nationwide Population-Based Study From 2007 to 2020
    Yoonjeong Choi, Ja-Ho Leigh, Jooeun Jeon, Goo Joo Lee, Hyung-Ik Shin, Moon Suk Bang
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • The Association between Metabolic Syndrome and Epithelial Cell Abnormalities Detected on Pap Smear: A Nationwide Population-Based Study
    Dayong Lee, Taek Sang Lee
    Journal of Clinical Medicine.2023; 12(8): 2954.     CrossRef
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    Eun‐Saem Choi, Young Mi Jung, Kyu‐Dong Cho, Sungyeon Ha, Jeongwon Sohn, Su Jung Hong, Min‐Jeong Oh, Chan‐Wook Park, Joong Shin Park, Jong Kwan Jun, Seung Mi Lee, Geum Joon Cho
    BJOG: An International Journal of Obstetrics & Gynaecology.2023; 130(11): 1370.     CrossRef
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    Young Ju Choi, Kyungdo Han, Won Kyoung Cho, Min Ho Jung, Byung-Kyu Suh
    Clinical Epidemiology.2023; Volume 15: 535.     CrossRef
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    Yeonjin Je, Kyungdo Han, Jaeyoung Chun, Yuna Kim, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park, Jong Pil Im, Joo Sung Kim
    Journal of Crohn's and Colitis.2023; 17(5): 681.     CrossRef
  • Lifestyle factors and long-term survival in patients with chronic non-cancer pain: a nationwide cohort study in South Korea
    Tak Kyu Oh, In-Ae Song
    Journal of Anesthesia.2023; 37(4): 522.     CrossRef
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    Kwang Hyun Lee, Ji Hye Bae, Jeesun Lee, Young Mi Jung, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Geum Joon Cho, Seung Mi Lee
    Obstetrics & Gynecology Science.2023; 66(3): 190.     CrossRef
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    Bokyung Kim, Kyungdo Han, Hyunsoo Chung, Sang Gyun Kim, Soo‐Jeong Cho
    Cancer.2023; 129(18): 2893.     CrossRef
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    Woo Hyun Paik, Dong Kee Jang, Soyoung Cho, Jin Ho Choi, Min Kyu Kim, In Rae Cho, Ji Kon Ryu, Yong-Tae Kim, Kyung-Do Han, Sang Hyub Lee
    Journal of Alzheimer's Disease.2023; 94(1): 205.     CrossRef
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    ZhiDa Soh, Ching-Yu Cheng
    Taiwan Journal of Ophthalmology.2023; 13(2): 123.     CrossRef
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  • Evaluating Reference Ages for Selecting Prosthesis Types for Heart Valve Replacement in Korea
    Sung Jun Park, You Jung Ok, Ho Jin Kim, Ye-Jee Kim, Seonok Kim, Jung-Min Ahn, Dae-Hee Kim, Jae-Sung Choi, Joon Bum Kim
    JAMA Network Open.2023; 6(5): e2314671.     CrossRef
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    Sangmo Hong, Kyungdo Han, Jung Hwan Park, Sung Hoon Yu, Chang Beom Lee, Dong Sun Kim
    Journal of Lipid and Atherosclerosis.2023; 12(2): 164.     CrossRef
  • Impact of Allergic Disease on the Risk of Mycobacterial Disease
    Taehee Kim, Hayoung Choi, Hyun Lee, Kyungdo Han, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Sang-Heon Kim
    The Journal of Allergy and Clinical Immunology: In Practice.2023; 11(9): 2830.     CrossRef
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  • Association between regular physical activity and lower incidence of colorectal cancer in patients with diabetes mellitus: a nationwide cohort study
    Han Hee Lee, Kyu‐na Lee, Jin Su Kim, Dae Young Cheung, Hyuk‐Sang Kwon, Bo‐In Lee, Young‐Seok Cho, Soo‐Heon Park, Kyungdo Han, Jin Il Kim
    Colorectal Disease.2023; 25(8): 1588.     CrossRef
  • Bovine pericardial versus porcine bioprosthetic mitral valves: results from a Korean Nationwide Cohort Study
    Hong Rae Kim, Jino Park, Sung Jun Park, Ho Jin Kim, Seonok Kim, Ye-Jee Kim, Jung-Min Ahn, Dae-Hee Kim, Joon Bum Kim
    European Journal of Cardio-Thoracic Surgery.2023;[Epub]     CrossRef
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  • Association of physical activity with total and cause-specific mortality in patients with diabetes: A nationwide population-based cohort study
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    Diabetes Research and Clinical Practice.2023; 202: 110819.     CrossRef
  • The Association Between Institutional Case Volume of Hematopoietic Stem Cell Transplantation and Mortality
    Leerang Lim, Eun Jin Jang, Jun Woo Jo, Junghoon Shin, Hyobin Lee, Hannah Lee, Seung-Young Oh, Hyunjae Im, Ho Geol Ryu
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  • Association between periodontal disease status and risk of atrial fibrillation: a nationwide population-based cohort study
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  • Trends in the incidence and prevalence of dysphagia requiring medical attention among adults in South Korea, 2006–2016: A nationwide population study
    SuYeon Kwon, Seungwoo Cha, Junsik Kim, Kyungdo Han, Nam-Jong Paik, Won-Seok Kim, Sina Azadnajafabad
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    Byungyoon Yun, Juyeon Oh, Jaesung Choi, Laura S. Rozek, Heejoo Park, Juho Sim, Yangwook Kim, Jongmin Lee, Jin-Ha Yoon
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    Tobacco Induced Diseases.2023; 21(July): 1.     CrossRef
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    Sangmo Hong, Kyung-Soo Kim, Kyungdo Han, Cheol-Young Park
    Kidney International.2023; 104(4): 820.     CrossRef
  • Comparative cardiovascular outcomes in type 2 diabetes patients taking dapagliflozin versus empagliflozin: a nationwide population-based cohort study
    Jaehyun Lim, You-Jung Choi, Bong Sung Kim, Tae-Min Rhee, Hyun-Jung Lee, Kyung-Do Han, Jun-Bean Park, Jin Oh Na, Yong-Jin Kim, Heesun Lee, Hyung-Kwan Kim
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Effects of Statin Treatment on the Development of Tendinopathy: A Nationwide Population-Based Cohort Study
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    Orthopaedic Journal of Sports Medicine.2023;[Epub]     CrossRef
  • Incident dementia in kidney transplantation recipients: a matched comparative nationwide cohort study in South Korea
    Seon Ha Baek, Jina Park, Sehoon Park, Mi-yeon Yu, Ji Eun Kim, Sang Hyun Park, Kyungdo Han, Yong Chul Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
    Kidney Research and Clinical Practice.2023; 42(4): 519.     CrossRef
  • Developing Operational Definitions Related toHelicobacter pyloriEradication Therapy
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    Journal of Korean Medical Science.2023;[Epub]     CrossRef
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    Ji Min Lee, Kyungdo Han, Kang-Moon Lee, Jae-Seung Yun
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Sex differences in mortality in patients with acromegaly: a nationwide cohort study in Korea
    Jiwon Kim, Namki Hong, Jimi Choi, Ju Hyung Moon, Eui Hyun Kim, Jae Won Hong, Eun Jig Lee, Sin Gon Kim, Cheol Ryong Ku
    European Journal of Endocrinology.2023; 189(2): 225.     CrossRef
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    Alimentary Pharmacology & Therapeutics.2023; 58(7): 668.     CrossRef
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    Pharmaceuticals.2023; 16(9): 1213.     CrossRef
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    Journal of Korean Medical Science.2023;[Epub]     CrossRef
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    PLOS ONE.2023; 18(10): e0292362.     CrossRef
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    Psychiatry Investigation.2023; 20(9): 834.     CrossRef
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    Ho-Young Yhim, Juhyun Lee, Kyoung Ha Kim, Sang-A Kim, Ji Yun Lee, Hun-Gyu Hwang, Junshik Hong, Jeong-Ok Lee, Soo-Mee Bang
    Thrombosis Research.2023; 231: 50.     CrossRef
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    Anesthesia & Analgesia.2023;[Epub]     CrossRef
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    Diabetes & Metabolism Journal.2023; 47(6): 846.     CrossRef
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    Journal of Big Data.2023;[Epub]     CrossRef
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    Journal of Personalized Medicine.2023; 13(9): 1414.     CrossRef
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    Journal of Psychiatric Research.2023; 167: 93.     CrossRef
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    Journal of Korean Medical Science.2023;[Epub]     CrossRef
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    Psychiatry Research.2023; 330: 115613.     CrossRef
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    Journal of the American Heart Association.2023;[Epub]     CrossRef
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    European Journal of Clinical Pharmacology.2023; 79(12): 1699.     CrossRef
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    The Open Neurology Journal.2023;[Epub]     CrossRef
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    Jae Hyun Kim, Gaeun Lee, Jinseub Hwang, Ji‐Won Kim, Jin‐Won Kwon, Yun‐Kyoung Song
    Journal of the American Heart Association.2023;[Epub]     CrossRef
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    Annals of Surgery.2023; 278(6): 1024.     CrossRef
  • Bovine pericardial versus porcine bioprosthetic aortic valves: A nationwide population-based cohort study in Korea
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    The Journal of Thoracic and Cardiovascular Surgery.2023;[Epub]     CrossRef
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    Journal of Clinical Medicine.2023; 13(1): 92.     CrossRef
  • Cost-effectiveness of the anti-vascular endothelial growth factor intravitreal injection and panretinal photocoagulation for patients with proliferative diabetic retinopathy in South Korea
    Hyeon-Jeong Lee, Songhee Cho, Jungeun Park, Yan Jin, Hyung Min Kim, Donghyun Jee
    BMC Health Services Research.2023;[Epub]     CrossRef
  • Prior Evaluation of Nutritional Status and Mortality in Patients with Sepsis in South Korea
    Tak Kyu Oh, In-Ae Song
    Nutrients.2023; 15(24): 5040.     CrossRef
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    Jiwon Kim, Namki Hong, Jimi Choi, Ju Hyung Moon, Eui Hyun Kim, Eun Jig Lee, Sin Gon Kim, Cheol Ryong Ku
    Endocrinology and Metabolism.2023; 38(6): 690.     CrossRef
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    Journal of Bone and Joint Surgery.2023;[Epub]     CrossRef
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    Sang-Yong Eom, Hyun-a Jang, Yo Han Im, Kyung-Hwa Choi, Ji Hyoun Kim
    Rheumatology.2023;[Epub]     CrossRef
  • Proton Pump Inhibitor Co-Therapy in Patients with Atrial Fibrillation Treated with Oral Anticoagulants and a Prior History of Upper Gastrointestinal Tract Bleeding
    So-Ryoung Lee, Soonil Kwon, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip
    Cardiovascular Drugs and Therapy.2022; 36(4): 679.     CrossRef
  • Institutional case volume-incorporated mortality risk prediction model for cardiac surgery
    Seohee Lee, Eun Jin Jang, Junwoo Jo, Dongnyeok Park, Ho Geol Ryu
    Asian Journal of Surgery.2022; 45(1): 189.     CrossRef
  • Does Surgical Ablation of Atrial Fibrillation Benefit Patients Undergoing Bioprosthetic Valve Replacement?
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    Seminars in Thoracic and Cardiovascular Surgery.2022; 34(3): 906.     CrossRef
  • Burden of comorbidities and medication use in childbearing women with rheumatic diseases: a nationwide population-based study
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    The Korean Journal of Internal Medicine.2022; 37(6): 1250.     CrossRef
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    Hepatology Communications.2022; 6(4): 740.     CrossRef
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    Hypertension.2022; 79(1): 218.     CrossRef
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    European Journal of Preventive Cardiology.2022; 29(3): 547.     CrossRef
  • Liver enzymes and risk of ocular motor cranial nerve palsy: a nationwide population-based study
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    Neurological Sciences.2022; 43(5): 3395.     CrossRef
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    Journal of Chemotherapy.2022; 34(8): 534.     CrossRef
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    Investigative and Clinical Urology.2022; 63(1): 92.     CrossRef
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    European Heart Journal.2022; 43(15): 1491.     CrossRef
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    Korean Circulation Journal.2022; 52(2): 136.     CrossRef
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    Investigative and Clinical Urology.2022; 63(1): 63.     CrossRef
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    Health Informatics Journal.2022; 28(1): 146045822110710.     CrossRef
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    Journal of Neurotrauma.2022; 39(5-6): 390.     CrossRef
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    Biomedicines.2022; 10(2): 303.     CrossRef
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    Clinical Nutrition Research.2022; 11(1): 32.     CrossRef
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    Resuscitation.2022; 173: 31.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    JAMA Network Open.2022; 5(2): e220262.     CrossRef
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    Endocrinology and Metabolism.2022; 37(1): 148.     CrossRef
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    Journal of Psychiatric Research.2022; 149: 226.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    The Breast.2022; 63: 46.     CrossRef
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    Journal of Bone and Mineral Metabolism.2022; 40(4): 602.     CrossRef
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    Archives of Orthopaedic and Trauma Surgery.2022; 143(5): 2307.     CrossRef
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    PLOS ONE.2022; 17(4): e0266262.     CrossRef
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    Cancer Research and Treatment.2022; 54(2): 572.     CrossRef
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    International Journal of Environmental Research and Public Health.2022; 19(9): 4949.     CrossRef
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    Nutrients.2022; 14(8): 1644.     CrossRef
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    Journal of Personalized Medicine.2022; 12(5): 691.     CrossRef
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    Clinical Psychopharmacology and Neuroscience.2022; 20(2): 320.     CrossRef
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    Frontiers in Neurology.2022;[Epub]     CrossRef
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    Cancers.2022; 14(11): 2604.     CrossRef
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    International Journal of Cancer.2022; 151(7): 1024.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    Hepatology Communications.2022; 6(9): 2455.     CrossRef
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    Gastroenterology.2022; 163(3): 637.     CrossRef
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    BMC Medicine.2022;[Epub]     CrossRef
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    Journal of Obesity & Metabolic Syndrome.2022; 31(2): 169.     CrossRef
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    Gut and Liver.2022; 16(4): 555.     CrossRef
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    Yonsei Medical Journal.2022; 63(8): 774.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    Journal of Personalized Medicine.2022; 12(8): 1260.     CrossRef
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    Journal of Cardiothoracic Surgery.2022;[Epub]     CrossRef
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    Hepatology Research.2022; 52(12): 975.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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  • Severe hypoglycemia and the risk of cardiovascular disease and mortality in type 2 diabetes: a nationwide population-based cohort study
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  • The Effects after Implementing a Drug Utilization Review System on Contraindicated Drug use: A Systematic Review
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  • Nationwide Trends in Pancreatitis and Pancreatic Cancer Risk Among Patients With Newly Diagnosed Type 2 Diabetes Receiving Dipeptidyl Peptidase 4 Inhibitors
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  • Dose–response relationship between cigarette smoking and risk of ulcerative colitis: a nationwide population-based study
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  • Is androgen deprivation therapy associated with cerebral infarction in patients with prostate cancer? A Korean nationwide population‐based propensity score matching study
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  • Adult lung transplantation case-volume and in-hospital and long-term mortality in Korea
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  • Validation of diagnostic codes of major clinical outcomes in a National Health Insurance database
    Jiesuck Park, Soonil Kwon, Eue-Keun Choi, You-jung Choi, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Seil Oh
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  • Prognostic influence of Korean public medical insurance system on breast cancer patients
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  • Effect of Case Volume on Mortality After Pediatric Liver Transplantation in Korea
    Hannah Lee, Eun Jin Jang, Ga Hee Kim, Nam Joon Yi, Dal Ho Kim, Seokha Yoo, Hyung Sang Row, Chul-Woo Jung, Seung-Young Oh, Ho Geol Ryu
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  • Prescription Patterns and Burden of Pediatric Asthma in Korea
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  • Increased risk of coronary heart disease and stroke in lung cancer survivors: A Korean nationwide study of 20,458 patients
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  • Waist Circumference and All-Cause Mortality Independent of Body Mass Index in Korean Population from the National Health Insurance Health Checkup 2009–2015
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  • Temporal trends in prevalence and antithrombotic treatment among Asians with atrial fibrillation undergoing percutaneous coronary intervention: A nationwide Korean population-based study
    Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, You-jung Choi, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Jeehoon Kang, Kyung Woo Park, Seil Oh, Gregory Y. H. Lip, Chiara Lazzeri
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  • Factors influencing the incidence and treatment of intracranial aneurysm and subarachnoid hemorrhage: time trends and socioeconomic disparities under an universal healthcare system
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    Journal of NeuroInterventional Surgery.2019; 11(2): 159.     CrossRef
  • Increasing trends in hospital care burden of atrial fibrillation in Korea, 2006 through 2015
    Daehoon Kim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip
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  • Appropriate Amount of Regular Exercise Is Associated with a Reduced Mortality Risk
    DA YOUNG LEE, EUN-JUNG RHEE, JUNG HWAN CHO, HYEMI KWON, SE EUN PARK, YANG-HYUN KIM, KYUNGDO HAN, YONG-KYU PARK, SOON JIB YOO, WON-YOUNG LEE
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  • The effect of continuity of care on the incidence of end-stage renal disease in patients with newly detected type 2 diabetic nephropathy: a retrospective cohort study
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    BMC Nephrology.2018;[Epub]     CrossRef
  • Increased end-stage renal disease risk in patients with inflammatory bowel disease: A nationwide population-based study
    Seona Park, Jaeyoung Chun, Kyung-Do Han, Hosim Soh, Kookhwan Choi, Ji Hye Kim, Jooyoung Lee, Changhyun Lee, Jong Pil Im, Joo Sung Kim
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  • Cardiovascular disease risk differences between bus company employees and general workers according to the Korean National Health Insurance Data
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  • Impact of Renal Function on Outcomes With Edoxaban in Real-World Patients With Atrial Fibrillation
    Hee Tae Yu, Pil-Sung Yang, Tae-Hoon Kim, Eunsun Jang, Daehoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y.H. Lip, Boyoung Joung
    Stroke.2018; 49(10): 2421.     CrossRef
  • Association between adult height, myocardial infarction, heart failure, stroke and death: a Korean nationwide population-based study
    Chan Soon Park, Eue-Keun Choi, Kyung-Do Han, Hyun Jung Lee, Tae-Min Rhee, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Si-Hyuck Kang, Seil Oh
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  • Dietary Fat Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies
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    Nutrients.2018; 10(12): 1963.     CrossRef
  • Association Between Changes in Hemoglobin Concentration and Cardiovascular Risks and All‐Cause Mortality Among Young Women
    Gyeongsil Lee, Seulggie Choi, Kyuwoong Kim, Jae‐Moon Yun, Joung Sik Son, Su‐Min Jeong, Sung Min Kim, Yeon‐Yong Kim, Seong Yong Park, Youngil Koh, Seung‐sik Hwang, Sang Min Park
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  • The economic burden of rotavirus infection in South Korea from 2009 to 2012
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  • Incidence and death rate of pemphigus vulgaris and pemphigus foliaceus in Korea: A nationwide, population‐based study (2006–2015)
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  • Protective Effect of Metformin Against Thyroid Cancer Development: A Population-Based Study in Korea
    Yoon Young Cho, Min Jin Kang, Soo Kyoung Kim, Jung Hwa Jung, Jong Ryeal Hahm, Tae Hyuk Kim, Joo Young Nam, Byung-Wan Lee, Yong-ho Lee, Jae Hoon Chung, Sun Ok Song, Sun Wook Kim
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  • Association of oral ciprofloxacin, levofloxacin, ofloxacin and moxifloxacin with the risk of serious ventricular arrhythmia: a nationwide cohort study in Korea
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  • Age Threshold for Ischemic Stroke Risk in Atrial Fibrillation
    Tae-Hoon Kim, Pil-Sung Yang, Hee Tae Yu, Eunsun Jang, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y.H. Lip
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  • Variations of Prevalence and Incidence of Atrial Fibrillation and Oral Anticoagulation Rate According to Different Analysis Approaches
    Pil-Sung Yang, Soorack Ryu, Daehoon Kim, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jinseub Hwang, Boyoung Joung, Gregory Y. H. Lip
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  • Reciprocal relationship between herpes zoster and cardiovascular diseases: A nationwide population‐based case–control study in Korea
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  • Hypertension and risk of psoriasis incidence: An 11-year nationwide population-based cohort study
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  • Association between abdominal obesity and increased risk for the development of hypertension regardless of physical activity: A nationwide population‐based study
    Eun‐Jung Rhee, Jung‐Hwan Cho, Hyemi Kwon, Se‐Eun Park, Jin‐Hyung Jung, Kyung‐Do Han, Yong‐Gyu Park, Hye Soon Park, Yang‐Hyun Kim, Soon‐Jib Yoo, Won‐Young Lee
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  • Prevalence of extraintestinal manifestations in Korean inflammatory bowel disease patients
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  • Need for Systematic Efforts to Modify Health-Related Behaviors After Acute Myocardial Infarction in Korea
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  • Association between diabetes and asthma
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  • Association between Height and Actinic Keratosis: A Nationwide Population-based Study in South Korea
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  • Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis
    Seung-Hyun Ko, Kyungdo Han, Yong-ho Lee, Junghyun Noh, Cheol-Young Park, Dae-Jung Kim, Chang Hee Jung, Ki-Up Lee, Kyung-Soo Ko
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  • Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseases
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  • A nationwide population-based study of common bile duct stone recurrence after endoscopic stone removal in Korea
    Byung Kyu Park, Jeong Hun Seo, Han Ho Jeon, Jong Won Choi, Sun Young Won, Yong Suk Cho, Chun Kyon Lee, Haeyong Park, Dong Wook Kim
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  • Estimating the impact of body mass index on bladder cancer risk: Stratification by smoking status
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  • Prevalence of Obesity and Incidence of Obesity-Related Comorbidities in Koreans Based on National Health Insurance Service Health Checkup Data 2006–2015
    Mi Hae Seo, Yang-Hyun Kim, Kyungdo Han, Jin-Hyung Jung, Yong-Gyu Park, Seong-Su Lee, Hyuk-Sang Kwon, Won-Young Lee, Soon Jib Yoo
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  • Association of Hemoglobin Concentration and Its Change With Cardiovascular and All‐Cause Mortality
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    Wonil Koh, Kyungwon Kang, Yoon Jae Lee, Me-riong Kim, Joon-Shik Shin, Jinho Lee, Jun-Hwan Lee, Kyung-Min Shin, In-Hyuk Ha, Qinhong Zhang
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  • The influence of diabetes and antidiabetic medications on the risk of pancreatic cancer: a nationwide population-based study in Korea
    Da Young Lee, Ji Hee Yu, Sanghyun Park, Kyungdo Han, Nam Hoon Kim, Hye Jin Yoo, Kyung Mook Choi, Sei Hyun Baik, Nan Hee Kim, Ji A. Seo
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    Young-Jae Hwang, Nayoung Kim, Chang Yong Yun, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Il Tae Son, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Hye Seung Lee, Seon Mee Park, Dong Ho Lee
    Journal of Cancer Prevention.2018; 23(4): 183.     CrossRef
  • J-Shaped Association Between Postoperative Levothyroxine Dosage and Fracture Risk in Thyroid Cancer Patients: A Retrospective Cohort Study
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    Journal of Bone and Mineral Research.2018; 33(6): 1037.     CrossRef
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  • Risk of ischemic stroke in metabolically healthy obesity: A nationwide population-based study
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  • Incidence, prevalence, and mortality of Adamantiades‐Behçet's disease in Korea: a nationwide, population‐based study (2006–2015)
    Y.B. Lee, S.Y. Lee, J.Y. Choi, J.H. Lee, H.S. Chae, J.W. Kim, K.D. Han, Y.G. Park, D.S. Yu
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  • Temporal trends of antithrombotic therapy for stroke prevention in Korean patients with non-valvular atrial fibrillation in the era of non-vitamin K antagonist oral anticoagulants: A nationwide population-based study
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  • Persistent smoking after a cardiovascular event: A nationwide retrospective study in Korea
    Yoo Kyoung Lim, Dong Wook Shin, Hyeon Suk Kim, Jae Moon Yun, Jung-Hyun Shin, Hyejin Lee, Hye Yeon Koo, Min Jung Kim, Jeong Yeon Yoon, Mi Hee Cho, Katriina Aalto-Setala
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    Yang-Hyun Kim, Seon Mee Kim, Kyung-do Han, Jang-Won Son, Seong-Su Lee, Sang Woo Oh, Won-Young Lee, Soon Jib Yoo
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  • Secondary Primary Prostate Cancer after Colorectal Cancer: A Nationwide Population-based Cohort Study in Korea
    Hyun Soo Kim, Yoon Jin Choi, Dong Woo Shin, Kyung-Do Han, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee
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  • Increasing burden of liver cancer despite extensive use of antiviral agents in a hepatitis B virus‐endemic population
    Jonggi Choi, Seungbong Han, Namkug Kim, Young‐Suk Lim
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  • Data Analytic Process of a Nationwide Population-Based Study on Obesity Using the National Health Information Database Presented by the National Health Insurance Service 2006-2015
    Yang-Hyun Kim, Kyungdo Han, Jang-Won Son, Seong-Su Lee, Sang Woo Oh, Hyuk-Sang Kwon, Soon-Ae Shin, Yeon-Yong Kim, Won-Young Lee, Soon Jib Yoo
    Journal of Obesity & Metabolic Syndrome.2017; 26(1): 23.     CrossRef
  • Trends in the incidence and prevalence of atrial fibrillation and estimated thromboembolic risk using the CHA2DS2-VASc score in the entire Korean population
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  • Home Return After Surgery in Patients Aged over 85 Years is Associated with Preoperative Albumin Levels, the Type of Surgery, and APACHE II Score
    Bora Lee, Sungwon Na, Miran Park, Sungyeon Ham, Jeongmin Kim
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  • Atrial fibrillation and the risk of myocardial infarction: a nation-wide propensity-matched study
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    Kyoung-Hun Yoo, Dong-Wook Shin, Mi-Hee Cho, Sang-Hyuck Kim, Hyun-Jung Bahk, Shin-Hye Kim, Su-Min Jeong, Jae-Moon Yun, Jin-Ho Park, Heesun Kim, BeLong Cho
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  • Pediatric fluoroquinolone prescription in South Korea before and after a regulatory intervention: A nationwide study, 2007-2015
    Seung Yeon Song, Joo Hee Shin, Su Yeong Hyeon, Donguk Kim, Won Ku Kang, Soo-Han Choi, Yae-Jean Kim, Eun Young Kim, Ravi Jhaveri
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  • Increased risk of thyroid diseases in patients with systemic lupus erythematosus: A nationwide population-based Study in Korea
    Jae-Seung Yun, Jung Min Bae, Ki-Jo Kim, Yu Seok Jung, Gyong Moon Kim, Hyung-Rae Kim, Jun-Seok Lee, Seung-Hyun Ko, Seon-Ah Cha, Yu-Bae Ahn, Ludmila Prokunina-Olsson
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  • Trends in the pervasiveness of type 2 diabetes, impaired fasting glucose and co-morbidities during an 8-year-follow-up of nationwide Korean population
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  • Impact of National Health Checkup Service on Hard Atherosclerotic Cardiovascular Disease Events and All-Cause Mortality in the General Population
    Yongsung Suh, Chan Joo Lee, Deok-Kyu Cho, Yun-Hyeong Cho, Dong-Ho Shin, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Yangsoo Jang, Myeong-Ki Hong
    The American Journal of Cardiology.2017; 120(10): 1804.     CrossRef
  • Data Analytic Process of a Nationwide Population-Based Study Using National Health Information Database Established by National Health Insurance Service
    Yong-ho Lee, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko, Ki-Up Lee
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  • Trends in Diabetes Incidence in the Last Decade Based on Korean National Health Insurance Claims Data
    Sun Ok Song, Yong-ho Lee, Dong Wook Kim, Young Duk Song, Joo Young Nam, Kyoung Hye Park, Dae Jung Kim, Seok Won Park, Hyun Chul Lee, Byung-Wan Lee
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    Hae Kyung Yang, Kyungdo Han, Hyuk-Sang Kwon, Yong-Moon Park, Jae-Hyoung Cho, Kun-Ho Yoon, Moo-Il Kang, Bong-Yun Cha, Seung-Hwan Lee
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  • Epidemiology of Type 1 Diabetes Mellitus in Korea through an Investigation of the National Registration Project of Type 1 Diabetes for the Reimbursement of Glucometer Strips with Additional Analyses Using Claims Data
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    American Journal of Industrial Medicine.2016; 59(5): 392.     CrossRef
  • Metabolic Risk Profile and Cancer in Korean Men and Women
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    Medicine.2016; 95(27): e4018.     CrossRef
  • Hypoglycemia is associated with dementia in elderly patients with type 2 diabetes mellitus: An analysis based on the Korea National Diabetes Program Cohort
    Sang Ouk Chin, Sang Youl Rhee, Suk Chon, Sei Hyun Baik, Yongsoo Park, Moon Suk Nam, Kwan Woo Lee, Ki Hong Chun, Jeong-taek Woo, Young Seol Kim
    Diabetes Research and Clinical Practice.2016; 122: 54.     CrossRef
  • How Can We Identify the Elimination of Infectious Diseases? Experience From an Active Measles Laboratory Surveillance System in the Republic of Korea
    Tae Un Yang, Hae Ji Kang, Hye Eun Eom, Young-Joon Park, Ok Park, Su Jin Kim, Jeong-Gu Nam, Sung Soon Kim, Eun Kyeong Jeong
    Asia Pacific Journal of Public Health.2015; 27(8_suppl): 101S.     CrossRef
  • The Population-Based Risk of Need for Coronary Revascularization According to the Presence of Type 2 Diabetes Mellitus and History of Coronary Heart Disease in the Korean Population
    Chang Hee Jung, Gi Hyeon Seo, Sunghwan Suh, Ji Cheol Bae, Mee Kyoung Kim, You-Cheol Hwang, Jae Hyeon Kim, Byung-Wan Lee, Xian Wu Cheng
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  • Response: Increased Risk of Hospitalization for Heart Failure with Newly Prescribed Dipeptidyl Peptidase-4 Inhibitors and Pioglitazone Using the Korean Health Insurance Claims Database (Diabetes Metab J2015;39:247-52)
    Sunghwan Suh, Gi Hyeon Seo, Chang Hee Jung, Mee-Kyoung Kim, Sang-Man Jin, You-Cheol Hwang, Byung-Wan Lee, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2015; 39(4): 350.     CrossRef
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Response
Response: The Prevalence of Peripheral Arterial Disease in Korean Patients with Type 2 Diabetes Mellitus Attending a University Hospital (Diabetes Metab J 2011;35:543-50)
Ji Hee Yu, Ki-Up Lee
Diabetes Metab J. 2012;36(1):77-78.   Published online February 17, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.1.77
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  • Low ankle-brachial index is an independent predictor of poor functional outcome in acute cerebral infarction
    Jinkwon Kim, Dong Hyun Lee, Myoung-Jin Cha, Tae-Jin Song, Ji Hye Park, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Ji Hoe Heo
    Atherosclerosis.2012; 224(1): 113.     CrossRef
Original Article
The Prevalence of Peripheral Arterial Disease in Korean Patients with Type 2 Diabetes Mellitus Attending a University Hospital
Ji Hee Yu, Jenie Yoonoo Hwang, Mi-Seon Shin, Chang Hee Jung, Eun Hee Kim, Sang Ah Lee, Eun Hee Koh, Woo Je Lee, Min-Seon Kim, Joong-Yeol Park, Ki-Up Lee
Diabetes Metab J. 2011;35(5):543-550.   Published online October 31, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.5.543
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AbstractAbstract PDFPubReader   
Background

Peripheral arterial disease (PAD) is a common manifestation of systemic atherosclerosis and is associated with significant morbidity and mortality. Diabetes is known to increase the risk of PAD two- to four-fold. The prevalence of PAD in Korean diabetic patients has not been established. In this study, we investigated the prevalence of PAD in Korean patients with type 2 diabetes attending a large university hospital and analyzed the factors associated with PAD.

Methods

A total of 2,002 patients with type 2 diabetes who underwent ankle-brachial index (ABI) measurement in an outpatient clinic were enrolled. PAD was defined as an ABI ≤0.9. Clinical characteristics of 64 patients with PAD were compared with those of 192 age- and sex-matched control patients without PAD.

Results

Of the 2,002 type 2 diabetic patients, 64 (3.2%) were diagnosed as having PAD. PAD was associated with higher prevalences of retinopathy, nephropathy, neuropathy, cerebrovascular and coronary artery disease. Patients with PAD had higher systolic blood pressure and serum triglyceride level and reported higher pack-years of smoking. Multivariate analysis showed that the presence of micro- and macrovascular complications and high systolic blood pressure are factors independently associated with PAD.

Conclusion

The prevalence of PAD in diabetic patients was 3.2%, suggesting that the prevalence in Korean diabetic patients is lower than that of patients in Western countries.

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    Jinkwon Kim, Dong Hyun Lee, Myoung-Jin Cha, Tae-Jin Song, Ji Hye Park, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Ji Hoe Heo
    Atherosclerosis.2012; 224(1): 113.     CrossRef
  • Letter: The Prevalence of Peripheral Arterial Disease in Korean Patients with Type 2 Diabetes Mellitus Attending a University Hospital (Diabetes Metab J 2011;35:543-50)
    Won Jun Kim, Cheol-Young Park
    Diabetes & Metabolism Journal.2011; 35(6): 637.     CrossRef
Response
Response: Lack of Association between Serum Cystatin C Levels and Coronary Artery Disease in Diabetic Patients (Korean Diabetes J 2010;34:95-100)
Eun Hee Kim, Ki-Up Lee
Korean Diabetes J. 2010;34(3):209-210.   Published online June 30, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.3.209
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  • Association Between Cathepsin S, Cystatin C and High Sensitivity C-Reactive Protein (hsCRP) with Oxidized LDL (Ox-LDL) in Men with Central Obesity
    Emmy F Harefa, Ilhamjaya Patellongi, Marita Kaniawati
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Original Article
Homocysteine as a Risk Factor for Development of Microalbuminuria in Type 2 Diabetes
Eun-Hee Cho, Eun Hee Kim, Won Gu Kim, Eun Hui Jeong, Eun Hee Koh, Woo-Je Lee, Min-Seon Kim, Joong-Yeol Park, Ki-Up Lee
Korean Diabetes J. 2010;34(3):200-206.   Published online June 30, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.3.200
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AbstractAbstract PDFPubReader   
Background

Kidney function is critical in homocysteine clearance, and plasma homocysteine level is frequently increased in patients with renal failure. On the other hand, recent studies in animals have shown that hyperhomocysteinemia induces renal injury. In this study, we determined whether hyperhomocysteinemia can be a risk factor for the development of microalbuminuria in patients with type 2 diabetes.

Methods

A nested case-control study. Of 887 patients with type 2 diabetes who did not have microalbuminuria at baseline, 76 developed microalbuminuria during follow-up (mean, 36.0 ± 11.7 months; range, 18 to 76 months). The control group consisted of 152 age- and sex-matched subjects who did not develop microalbuminuria. Baseline plasma homocysteine concentrations were measured in stored samples.

Results

Baseline plasma homocysteine concentrations and mean HbA1C levels during follow-up were significantly higher in patients who developed microalbuminuria than in those who remained normoalbuminuric. Multivariate logistic regression analysis showed that baseline plasma homocysteine level and mean HbA1C were independent predictors of microalbuminuria in type 2 diabetes.

Conclusion

Hyperhomocysteinemia was associated with increased risk of microalbuminuria in patients with type 2 diabetes supporting the concept that hyperhomocysteinemia has an etiologic role in the pathogenesis of diabetic nephropathy.

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    Jae Hee Ahn, Ji Hee Yu, Seung-Hyun Ko, Hyuk-Sang Kwon, Dae Jung Kim, Jae Hyeon Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Soo Lim, Sung Hee Choi, Kyungdo Han, Bong-Yun Cha, Nan Hee Kim
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Review
Adenine Nucleotide Translocator as a Regulator of Mitochondrial Function: Implication in the Pathogenesis of Metabolic Syndrome
Eun Hee Kim, Eun Hee Koh, Joong-Yeol Park, Ki-Up Lee
Korean Diabetes J. 2010;34(3):146-153.   Published online June 30, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.3.146
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AbstractAbstract PDFPubReader   

Mitochondria play key roles in energy production and intracellular reactive oxygen species (ROS) generation. Lines of evidence have shown that mitochondrial dysfunction contributes to the development of metabolic syndrome. The causes of mitochondrial dysfunction are complex, but overnutrition and sedentary living are among the best known causes of mitochondrial dysfunction. ATP synthesized in the mitochondria is exchanged for cytosolic ADP by adenine nucleotide translocator (ANT) to provide a continuous supply of ADP to mitochondria. We recently found that ANT function is essential for peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC-1α)'s action on endothelial cells. PGC-1α is a transcriptional coactivator of nuclear receptors, playing an important role in fatty acid oxidation and mitochondrial biogenesis. Recent studies have shown that PGC-1α decreases intracellular ROS generation by increasing the expression of antioxidant genes. In our study, PGC-1α reduced cell apoptosis and ROS generation in endothelial cells by increasing ATP/ADP translocase activity of ANT and ANT1 expression. Here we review the role of ANT in maintaining proper mitochondrial function, and possible role of ANT dysfunction in the pathogenesis of metabolic syndrome.

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Original Article
Lack of Association between Serum Cystatin C Levels and Coronary Artery Disease in Diabetic Patients
Eun Hee Kim, Ji Hee Yu, Sang Ah Lee, Eui Young Kim, Won Gu Kim, Seung Hun Lee, Eun Hee Cho, Eun Hee Koh, Woo Je Lee, Min-Seon Kim, Joong-Yeol Park, Ki-Up Lee
Korean Diabetes J. 2010;34(2):95-100.   Published online April 30, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.2.95
  • 4,301 View
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AbstractAbstract PDFPubReader   
Background

Serum cystatin C level is a more sensitive marker of renal dysfunction than serum creatinine level. Serum cystatin C level was recently reported to predict the development of cardiovascular disease. This study was performed to evaluate whether the cystatin C level is associated with coronary artery disease (CAD), independent of diabetic nephropathy.

Methods

We conducted a case-control study to assess the relationship between serum cystatin C level and coronary artery disease in diabetic patients. Among 460 diabetic patients, 38 diabetic patients had CAD. The control group consisted of 38 diabetic patients who were matched to cases by age, sex, and presence/absence of diabetic nephropathy. Serum cystatin C level was measured in stored samples.

Results

Serum cystatin C level was significantly higher in patients with diabetic nephropathy, both in CAD and non-CAD patients. However, serum cystatin C level did not differ between CAD and non-CAD patients, regardless of diabetic nephropathy.

Conclusion

Serum cystatin C level is a marker of renal dysfunction, but not coronary artery disease, in diabetic patients.

Citations

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  • Higher Levels of Cystatin C in HIV/AIDS Patients with Metabolic Syndrome
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  • Response: Lack of Association between Serum Cystatin C Levels and Coronary Artery Disease in Diabetic Patients (Korean Diabetes J 2010;34:95-100)
    Eun Hee Kim, Ki-Up Lee
    Korean Diabetes Journal.2010; 34(3): 209.     CrossRef
  • Serum Cystatin C as a Biomarker for Predicting Coronary Artery Disease in Diabetes
    Jee-Young Oh
    Korean Diabetes Journal.2010; 34(2): 84.     CrossRef
  • Letter: Lack of Association between Serum Cystatin C Levels and Coronary Artery Disease in Diabetic Patients (Korean Diabetes J 2010;34:95-100)
    Kyu-Chang Won
    Korean Diabetes Journal.2010; 34(3): 207.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal