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Original Article
Metabolic Risk/Epidemiology
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Novel Asian-Specific Visceral Adiposity Indices Are Associated with Chronic Kidney Disease in Korean Adults
Jonghwa Jin, Hyein Woo, Youngeun Jang, Won-Ki Lee, Jung-Guk Kim, In-Kyu Lee, Keun-Gyu Park, Yeon-Kyung Choi
Diabetes Metab J. 2023;47(3):426-436.   Published online March 6, 2023
DOI: https://doi.org/10.4093/dmj.2022.0099
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  • 130 Download
  • 1 Web of Science
  • 2 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
The Chinese visceral adiposity index (CVAI) and new visceral adiposity index (NVAI) are novel indices of visceral adiposity used to predict metabolic and cardiovascular diseases in Asian populations. However, the relationships of CVAI and NVAI with chronic kidney disease (CKD) have not been investigated. We aimed to characterize the relationships of CVAI and NVAI with the prevalence of CKD in Korean adults.
Methods
A total of 14,068 participants in the 7th Korea National Health and Nutrition Examination Survey (6,182 men and 7,886 women) were included. Receiver operating characteristic (ROC) analyses were employed to compare the associations between indices of adiposity and CKD, and a logistic regression model was used to characterize the relationships of CVAI and NVAI with CKD prevalence.
Results
The areas under the ROC curves for CVAI and NVAI were significantly larger than for the other indices, including the visceral adiposity index and lipid accumulation product, in both men and women (all P<0.001). In addition, high CVAI or NVAI was significantly associated with a high CKD prevalence in both men (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.31 to 3.48 in CVAI and OR, 6.47; 95% CI, 2.91 to 14.38 in NVAI, P<0.05) and women (OR, 4.87; 95% CI, 1.85 to 12.79 in CVAI and OR, 3.03; 95% CI, 1.35 to 6.82 in NVAI, P<0.05); this association remained significant after adjustment for multiple confounding factors in men and women.
Conclusion
CVAI and NVAI are positively associated with CKD prevalence in a Korean population. CVAI and NVAI may be useful for the identification of CKD in Asian populations, including in Korea.

Citations

Citations to this article as recorded by  
  • Accessing the relationship between six surrogate insulin resistance indexes and the incidence of rapid kidney function decline and the progression to chronic kidney disease among middle-aged and older adults in China: Results from the China health and ret
    Siti Liu, Honglin Sun, Jia Liu, Guang Wang
    Diabetes Research and Clinical Practice.2024; 212: 111705.     CrossRef
  • Association between Chinese visceral adiposity index and risk of stroke incidence in middle-aged and elderly Chinese population: evidence from a large national cohort study
    Zenglei Zhang, Lin Zhao, Yiting Lu, Xu Meng, Xianliang Zhou
    Journal of Translational Medicine.2023;[Epub]     CrossRef
Response
Impact of Social Distancing Due to Coronavirus Disease 2019 on the Changes in Glycosylated Hemoglobin Level in People with Type 2 Diabetes Mellitus (Diabetes Metab J 2021;45:109-14)
Sung-Don Park, Sung-Woo Kim, Jun Sung Moon, Jae-Han Jeon, Mi Kyung Kim, Keun-Gyu Park
Diabetes Metab J. 2021;45(2):279-280.   Published online March 25, 2021
DOI: https://doi.org/10.4093/dmj.2020.0300
  • 4,436 View
  • 87 Download
  • 1 Crossref
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Citations

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  • A cross-sectional study on the telemedicine usage and glycemic status of diabetic patients during the COVID-19 pandemic
    Novi Sulistia Wati, Pokkate Wongsasuluk, Pradana Soewondo
    Medical Journal of Indonesia.2021; 30(3): 215.     CrossRef
Short Communication
COVID-19
Article image
Impact of Social Distancing Due to Coronavirus Disease 2019 on the Changes in Glycosylated Hemoglobin Level in People with Type 2 Diabetes Mellitus
Sung-Don Park, Sung-Woo Kim, Jun Sung Moon, Yin Young Lee, Nan Hee Cho, Ji-Hyun Lee, Jae-Han Jeon, Yeon-Kyung Choi, Mi Kyung Kim, Keun-Gyu Park
Diabetes Metab J. 2021;45(1):109-114.   Published online December 4, 2020
DOI: https://doi.org/10.4093/dmj.2020.0226
  • 9,736 View
  • 309 Download
  • 24 Web of Science
  • 24 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
This study investigated the impact of social distancing due to coronavirus disease 2019 (COVID-19) on glycemic control in people with type 2 diabetes mellitus (T2DM). We retrospectively analyzed the change in glycosylated hemoglobin level (ΔHbA1c) in people with T2DM who undertook social distancing because of COVID-19. We compared the ΔHbA1c between COVID-19 and non-COVID-19 cohorts that were enrolled at the same time of year. The ΔHbA1c of the COVID-19 cohort was significantly higher than that of two non-COVID-19 cohorts. Subgroup analysis according to age and baseline HbA1c level showed that social distancing significantly increased the mean HbA1c level of participants of <50 years. The ΔHbA1c of participants of <50 years and with HbA1c <7.0% in the COVID-19 cohort showed larger changes than other subgroups. In adjusted model, adjusted ΔHbA1c levels in the COVID-19 cohort remained significantly higher than those in the two other cohorts. Social distancing negatively impacts blood glucose control in people with T2DM, especially those who are younger and have good blood glucose control.

Citations

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  • Impact of two COVID-19 lockdowns on HbA1c levels in patients with type 2 diabetes and associations with patient characteristics: a multicentre, observational cohort study over three years
    Ingmar Schäfer, Daniel Tajdar, Laura Walther, Lasse Bittner, Dagmar Lühmann, Martin Scherer
    Frontiers in Public Health.2024;[Epub]     CrossRef
  • Influence of the COVID-19 pandemic on the achievement of guideline targets for HbA1c, blood pressure, and LDL cholesterol in people with diabetes in Japan
    Shingo Kuwajima, Takahito Itoh, Tatsuya Sato, Shoya Ino, Satoru Shibata, Kouhei Ohno, Hiroyuki Hotta, Tomoaki Matsumoto, Hitoshi Ooiwa, Hirofumi Kubo, Takayuki Miki
    Diabetology International.2024;[Epub]     CrossRef
  • Socioeconomic status and the effect of prolonged pandemic confinement on anthropometric and glycaemic outcomes in adults with type 2 diabetes mellitus
    Chandana Wijeweera, Ummul Muhfaza, Reginald V. Lord, Peter Petocz, Juliana Chen, Veronica Preda
    Primary Care Diabetes.2024; 18(3): 308.     CrossRef
  • Physical and Mental Health Characteristics of Hospitalized COVID-19 Patients with and without Type 2 Diabetes Mellitus in Turkey
    Abdulbari Bener, Murat Atmaca, Abdulla O. A. A. Al-Hamaq, Antonio Ventriglio
    Brain Sciences.2024; 14(4): 377.     CrossRef
  • Self-Care of Adults with Type 2 Diabetes During the COVID-19 Pandemic: A Qualitative Interpretive Description Study
    Michela Luciani, Camilla Bigoni, Marta Canesi, Matteo Masotto, Diletta Fabrizi, Stefania Di Mauro, Davide Ausili
    Clinical Nursing Research.2023; 32(1): 73.     CrossRef
  • Changes in body weight and glycemic control in association with COVID-19 Shutdown among 23,000 adults with type 2 diabetes
    Emily Panza, Kevin E. Kip, Kripa Venkatakrishnan, Oscar C. Marroquin, Rena R. Wing
    Acta Diabetologica.2023; 60(6): 787.     CrossRef
  • The Impact of a Lockdown for the COVID-19 Pandemic on Seasonal HbA1c Variation in Patients with Type 2 Diabetes
    Yu-Cheng Cheng, Yu-Hsuan Li, Hsiu-Chen Liu, Chiann-Yi Hsu, Wan-Jen Chang, I-Te Lee, Chin-Li Lu
    Life.2023; 13(3): 763.     CrossRef
  • Changes in the mean incidence and variance of orthopedic diseases before and during the COVID-19 pandemic in Korea: a retrospective study
    Joo-Hee Kim, Mi Jung Kwon, Hyo Geun Choi, Sang Jun Lee, Sangwon Hwang, Jaemin Lee, San-Hui Lee, Jung Woo Lee
    BMC Musculoskeletal Disorders.2023;[Epub]     CrossRef
  • Gender differences-based bioinformatics analysis to identify hub genes and key pathways in type 2 diabetes
    Md Sojib Hossain, Subrina Islam Rupa, Md Sumon Sarkar, Md Al Amin, Mst Tania Khatun, Md Shamim, Md Zahidul Islam
    Informatics in Medicine Unlocked.2023; 40: 101302.     CrossRef
  • Retrospective Study on the Impact of COVID-19 Lockdown on Patients with Type 2 Diabetes in Northern Taiwan
    Hsuan Huang, Hsiao-Ling Su, Chih-Hsung Huang, Yi-Hsin Lin
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 2539.     CrossRef
  • Understanding impacts of COVID-19 restrictions on glycemic control for patients with diabetes in Japan
    Kiyoko Uno-Eder, Noriko Satoh-Asahara, Manabu Hibiya, Kenji Uno, Takuya Uchino, Koji Morita, Toshio Ishikawa, Tetsuji Kaneko, Hajime Yamakage, Yuki Kitaoka, Tomohiro Sawa, Kazuhisa Tsukamoto, Tamio Teramoto
    Journal of Diabetes & Metabolic Disorders.2023; 22(2): 1695.     CrossRef
  • Impacts of the COVID-19 pandemic on unmet social needs, self-care, and outcomes among people with diabetes and poor glycemic control
    Minal R. Patel, Guanghao Zhang, Cindy Leung, Peter X.K. Song, Michele Heisler, Hae Mi Choe, Roshanak Mehdipanah, Xu Shi, Kenneth Resnicow, Geila Rajaee, John D. Piette
    Primary Care Diabetes.2022; 16(1): 57.     CrossRef
  • Impact of the COVID-19 Pandemic on Glycemic Control and Blood Pressure Control in Patients with Diabetes in Japan
    Keisuke Endo, Takayuki Miki, Takahito Itoh, Hirofumi Kubo, Ryosuke Ito, Kouhei Ohno, Hiroyuki Hotta, Nobuo Kato, Tomoaki Matsumoto, Aya Kitamura, Mai Tamayama, Takako Wataya, Ayaka Yamaya, Rei Ishikawa, Hitoshi Ooiwa
    Internal Medicine.2022; 61(1): 37.     CrossRef
  • The Effects of COVID-19 Lockdown on Glycaemic Control and Lipid Profile in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
    Omorogieva Ojo, Xiao-Hua Wang, Osarhumwese Osaretin Ojo, Edith Orjih, Nivedita Pavithran, Amanda Rodrigues Amorim Adegboye, Qian-Qian Feng, Paul McCrone
    International Journal of Environmental Research and Public Health.2022; 19(3): 1095.     CrossRef
  • Lifestyles Under Lockdown: A Scoping Review of International Studies on Type 2 Diabetes Self-Management Behaviors During COVID-19
    Caroline Cummings, Kagnica Seng, Ryan Tweet, Julie Wagner
    Frontiers in Clinical Diabetes and Healthcare.2022;[Epub]     CrossRef
  • Substitution of telemedicine for clinic visit during the COVID‐19 pandemic of 2020: Comparison of telemedicine and clinic visit
    Yukiko Onishi, Rieko Ichihashi, Yoko Yoshida, Tazu Tahara, Takako Kikuchi, Toshiko Kobori, Tetsuya Kubota, Masahiko Iwamoto, Shoko Hamano, Masato Kasuga
    Journal of Diabetes Investigation.2022; 13(9): 1617.     CrossRef
  • The impact of the COVID-19 pandemic on the management of patients with chronic diseases in Primary Health Care
    Panagiotis Stachteas, Manolis Symvoulakis, Apostolos Tsapas, Emmanouil Smyrnakis
    Population Medicine.2022; 4(August): 1.     CrossRef
  • Effects of COVID-19 Pandemic and Lockdown on Monitoring and Treatment Balance of Finnish Coronary Heart Disease and Type 2 Diabetes Patients
    Piia Lavikainen, Marja-Leena Lamidi, Teppo Repo, Laura Inglin, Janne Martikainen, Tiina Laatikainen
    Clinical Epidemiology.2022; Volume 14: 1363.     CrossRef
  • Impact of Social Distancing Due to Coronavirus Disease 2019 on the Changes in Glycosylated Hemoglobin Level in People with Type 2 Diabetes Mellitus (Diabetes Metab J 2021;45:109-14)
    Junghyun Noh
    Diabetes & Metabolism Journal.2021; 45(2): 275.     CrossRef
  • Impact of Social Distancing Due to Coronavirus Disease 2019 on the Changes in Glycosylated Hemoglobin Level in People with Type 2 Diabetes Mellitus (Diabetes Metab J 2021;45:109-14)
    Sung-Don Park, Sung-Woo Kim, Jun Sung Moon, Jae-Han Jeon, Mi Kyung Kim, Keun-Gyu Park
    Diabetes & Metabolism Journal.2021; 45(2): 279.     CrossRef
  • Glucose control in diabetes during home confinement for the first pandemic wave of COVID-19: a meta-analysis of observational studies
    Giovanni Antonio Silverii, Chiara Delli Poggi, Ilaria Dicembrini, Matteo Monami, Edoardo Mannucci
    Acta Diabetologica.2021; 58(12): 1603.     CrossRef
  • The impact of COVID-19 pandemic on glycemic control in patients with diabetes mellitus in Turkey: a multi-center study from Kocaeli
    Alev Selek, Emre Gezer, Eda Altun, Mehmet Sözen, Ömercan Topaloğlu, Damla Köksalan, Halil Demirkan, Dilek Karakaya, Berrin Cetinarslan, Zeynep Cantürk, Dilek Taymez
    Journal of Diabetes & Metabolic Disorders.2021; 20(2): 1461.     CrossRef
  • Effects of Social Distancing on Diabetes Management in Older Adults during COVID-19 Pandemic
    Soo Myoung Shin, Tae Jung Oh, Sung Hee Choi, Hak Chul Jang
    Diabetes & Metabolism Journal.2021; 45(5): 765.     CrossRef
  • Year-Long Trend in Glycated Hemoglobin Levels in Patients with Type 2 Diabetes during the COVID-19 Pandemic
    Jonghwa Jin, Seong Wook Lee, Won-Ki Lee, Jae-Han Jeon, Jung-Guk Kim, In-Kyu Lee, Yeon-Kyung Choi, Keun-Gyu Park
    Endocrinology and Metabolism.2021; 36(5): 1142.     CrossRef
Original Article
Covid-19
Article image
The Clinical Characteristics and Outcomes of Patients with Moderate-to-Severe Coronavirus Disease 2019 Infection and Diabetes in Daegu, South Korea
Mi Kyung Kim, Jae-Han Jeon, Sung-Woo Kim, Jun Sung Moon, Nan Hee Cho, Eugene Han, Ji Hong You, Ji Yeon Lee, Miri Hyun, Jae Seok Park, Yong Shik Kwon, Yeon-Kyung Choi, Ki Tae Kwon, Shin Yup Lee, Eon Ju Jeon, Jin-Woo Kim, Hyo-Lim Hong, Hyun Hee Kwon, Chi Young Jung, Yin Young Lee, Eunyeoung Ha, Seung Min Chung, Jian Hur, June Hong Ahn, Na-young Kim, Shin-Woo Kim, Hyun Ha Chang, Yong Hoon Lee, Jaehee Lee, Keun-Gyu Park, Hyun Ah Kim, Ji-Hyun Lee
Diabetes Metab J. 2020;44(4):602-613.   Published online August 12, 2020
DOI: https://doi.org/10.4093/dmj.2020.0146
  • 13,792 View
  • 209 Download
  • 70 Web of Science
  • 79 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

Coronavirus disease 2019 (COVID-19) is a global pandemic that had affected more than eight million people worldwide by June 2020. Given the importance of the presence of diabetes mellitus (DM) for host immunity, we retrospectively evaluated the clinical characteristics and outcomes of moderate-to-severe COVID-19 in patients with diabetes.

Methods

We conducted a multi-center observational study of 1,082 adult inpatients (aged ≥18 years) who were admitted to one of five university hospitals in Daegu because of the severity of their COVID-19-related disease. The demographic, laboratory, and radiologic findings, and the mortality, prevalence of severe disease, and duration of quarantine were compared between patients with and without DM. In addition, 1:1 propensity score (PS)-matching was conducted with the DM group.

Results

Compared with the non-DM group (n=847), patients with DM (n=235) were older, exhibited higher mortality, and required more intensive care. Even after PS-matching, patients with DM exhibited more severe disease, and DM remained a prognostic factor for higher mortality (hazard ratio, 2.40; 95% confidence interval, 1.38 to 4.15). Subgroup analysis revealed that the presence of DM was associated with higher mortality, especially in older people (≥70 years old). Prior use of a dipeptidyl peptidase-4 inhibitor or a renin-angiotensin system inhibitor did not affect mortality or the clinical severity of the disease.

Conclusion

DM is a significant risk factor for COVID-19 severity and mortality. Our findings imply that COVID-19 patients with DM, especially if elderly, require special attention and prompt intensive care.

Citations

Citations to this article as recorded by  
  • Potential use of sodium glucose co-transporter 2 inhibitors during acute illness: a systematic review based on COVID-19
    Carmen Tisch, Eleni Xourgia, Aristomenis Exadaktylos, Mairi Ziaka
    Endocrine.2024;[Epub]     CrossRef
  • Insulin and Metformin Administration: Unravelling the Multifaceted Association with Mortality across Various Clinical Settings Considering Type 2 Diabetes Mellitus and COVID-19
    Łukasz Lewandowski, Agnieszka Bronowicka-Szydełko, Maciej Rabczyński, Dorota Bednarska-Chabowska, Joanna Adamiec-Mroczek, Adrian Doroszko, Małgorzata Trocha, Krzysztof Kujawa, Agnieszka Matera-Witkiewicz, Edwin Kuźnik, Paweł Lubieniecki, Marcin Madziarski
    Biomedicines.2024; 12(3): 605.     CrossRef
  • Prognostic Value of Hyperglycemia and Insulin Resistance Among Patients with Confirmed COVID-19 Infections at Admission to the Alexandria Fever Hospital, Egypt
    Fathy Z. Alsewy, Magdy H. Megallaa, Salma A. Imbaby, Huda M. Zidan, Heba S. Kassab, Mai H. Badrah
    Metabolic Syndrome and Related Disorders.2024;[Epub]     CrossRef
  • The Effect of Antihyperglycemic Medications on COVID-19: A Meta-analysis and Systematic Review from Observational Studies
    Zhi-Hui Song, Qiao-Ming Huang, Shan-Shan Xu, Jian-Bo Zhou, Chao Zhang
    Therapeutic Innovation & Regulatory Science.2024; 58(4): 773.     CrossRef
  • The relationship of age, sex and prothrombin time related to the severity and mortality of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis
    Audrey Fabianisa Mirza, Ceria Halim, Mutiara Indah Sari
    F1000Research.2024; 11: 729.     CrossRef
  • The therapeutic potential of the use of gliclazide MV in combination with COVID-19 and type 2 diabetes mellitus
    D. V. Belikina, T. A. Nekrasova, L. G. Strongin, E. M. Durygina, M. Yu. Rodina
    FOCUS. Endocrinology.2024; 5(1): 20.     CrossRef
  • Research status and hotspots in the field of endoplasmic reticulum stress and liver disease: A bibliometric study
    Ruiyu Wang, Shu Huang, Ping Wang, Xiaowei Tang, Huan Xu, Wei Zhang, Lei Shi, Xiaolin Zhong, Muhan Lü, Xian Zhou, Xiaomin Shi
    Medicine.2024; 103(22): e38450.     CrossRef
  • Pre-admission use of sodium glucose transporter-2 inhibitor (SGLT-2i) may significantly improves Covid-19 outcomes in patients with diabetes: A systematic review, meta-analysis, and meta-regression
    Hikmat Permana, Theo Audi Yanto, Timotius Ivan Hariyanto
    Diabetes Research and Clinical Practice.2023; 195: 110205.     CrossRef
  • Risk phenotypes of diabetes and association with COVID-19 severity and death: an update of a living systematic review and meta-analysis
    Sabrina Schlesinger, Alexander Lang, Nikoletta Christodoulou, Philipp Linnerz, Kalliopi Pafili, Oliver Kuss, Christian Herder, Manuela Neuenschwander, Janett Barbaresko, Michael Roden
    Diabetologia.2023; 66(8): 1395.     CrossRef
  • Factors influencing the severity of COVID-19 course for patients with diabetes mellitus in tashkent: a retrospective cohort study
    A. V. Alieva, A. A. Djalilov, F. A. Khaydarova, A. V. Alimov, D. Z. Khalilova, V. A. Talenova, N. U. Alimova, M. D. Aripova, A. S. Sadikova
    Obesity and metabolism.2023; 20(2): 92.     CrossRef
  • Pituitary Diseases and COVID-19 Outcomes in South Korea: A Nationwide Cohort Study
    Jeonghoon Ha, Kyoung Min Kim, Dong-Jun Lim, Keeho Song, Gi Hyeon Seo
    Journal of Clinical Medicine.2023; 12(14): 4799.     CrossRef
  • Epidemiological features and consequences of COVID‐19 in patients with and without gastrointestinal symptoms in southwestern Iran. A retrospective observational study
    Habibollah Azarbakhsh, Leila Moftakhar, Aliasghar Valipour, Alireza Mirahmadizadeh, Hekmat Allah Moradi, Elahe Piraee
    Health Science Reports.2023;[Epub]     CrossRef
  • The Impact of Long-Term Conditions and Comorbidity Patterns on COVID-19 Infection and Hospitalisation: A Cohort Study
    Yun-Ting Huang, Andrew Steptoe, Riyaz S. Patel, Esme Fuller Thomson, Dorina Cadar
    Gerontology.2023; 69(10): 1200.     CrossRef
  • Association Between Anti-diabetic Agents and Clinical Outcomes of COVID-19 in Patients with Diabetes: A Systematic Review and Meta-Analysis
    Tiantian Han, Shaodi Ma, Chenyu Sun, Huimei Zhang, Guangbo Qu, Yue Chen, Ce Cheng, Eric L. Chen, Mubashir Ayaz Ahmed, Keun Young Kim, Raveena Manem, Mengshi Chen, Zhichun Guo, Hongru Yang, Yue Yan, Qin Zhou
    Archives of Medical Research.2022; 53(2): 186.     CrossRef
  • Use of DPP4i reduced odds of clinical deterioration and hyperinflammatory syndrome in COVID-19 patients with type 2 diabetes: Propensity score analysis of a territory-wide cohort in Hong Kong
    Carlos K.H. Wong, David T.W. Lui, Angel Y.C. Lui, Ashley C.Y. Kwok, Marshall C.H. Low, Kristy T.K. Lau, Ivan C.H. Au, Xi Xiong, Matthew S.H. Chung, Eric H.Y. Lau, Benjamin J. Cowling
    Diabetes & Metabolism.2022; 48(1): 101307.     CrossRef
  • Dipeptidyl peptidase-4 (DPP-IV) inhibitor was associated with mortality reduction in COVID-19 — A systematic review and meta-analysis
    Ahmad Fariz Malvi Zamzam Zein, Wilson Matthew Raffaello
    Primary Care Diabetes.2022; 16(1): 162.     CrossRef
  • Prevalence and impact of diabetes in hospitalized COVID‐19 patients: A systematic review and meta‐analysis
    Sian A. Bradley, Maciej Banach, Negman Alvarado, Ivica Smokovski, Sonu M. M. Bhaskar
    Journal of Diabetes.2022; 14(2): 144.     CrossRef
  • Interplay between Inflammaging, Frailty and Nutrition in Covid-19: Preventive and Adjuvant Treatment Perspectives
    A. Padilha de Lima, M. Macedo Rogero, T. Araujo Viel, H.M. Garay-Malpartida, I. Aprahamian, Sandra Maria Lima Ribeiro
    The Journal of nutrition, health and aging.2022; 26(1): 67.     CrossRef
  • Increase in blood glucose level and incidence of diabetic ketoacidosis in children with type 1 diabetes mellitus in the Daegu-Gyeongbuk area during the coronavirus disease 2019 (COVID-19) pandemic: a retrospective cross-sectional study
    Mi Seon Lee, Rosie Lee, Cheol Woo Ko, Jung Eun Moon
    Journal of Yeungnam Medical Science.2022; 39(1): 46.     CrossRef
  • Interrelationship between 2019-nCov receptor DPP4 and diabetes mellitus targets based on protein interaction network
    Qian Gao, Wenjun Zhang, Tingting Li, Guojun Yang, Wei Zhu, Naijun Chen, Huawei Jin
    Scientific Reports.2022;[Epub]     CrossRef
  • Can sodium-glucose co-transporter-2 (SGLT-2) inhibitor reduce the risk of adverse complications due to COVID-19? – Targeting hyperinflammation
    Afnan Alshnbari, Iskandar Idris
    Current Medical Research and Opinion.2022; 38(3): 357.     CrossRef
  • Commentary: Mortality Risk of Antidiabetic Agents for Type 2 Diabetes With COVID-19: A Systematic Review and Meta-Analysis
    Li-Min Zhao, Xie-Hui Chen, Mei Qiu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • COVID-19 and Diabetes
    Awadhesh Kumar Singh, Kamlesh Khunti
    Annual Review of Medicine.2022; 73(1): 129.     CrossRef
  • The enzymes in COVID-19: A review
    Maria Helena Menezes Estevam Alves, Layla Carvalho Mahnke, Tifany Cerqueira Macedo, Thais Ketinly dos Santos Silva, Luiz Bezerra Carvalho Junior
    Biochimie.2022; 197: 38.     CrossRef
  • IMPACT OF ANTIDIABETIC DRUGS ON RISK AND OUTCOME OF COVID-19 INFECTION: A REVIEW
    Adnan A. Zainal, Marwan M. Merkhan
    Military Medical Science Letters.2022; 91(2): 140.     CrossRef
  • Does metformin affect outcomes in COVID‐19 patients with new or pre‐existing diabetes mellitus? A systematic review and meta‐analysis
    Adithan Ganesh, Michael D. Randall
    British Journal of Clinical Pharmacology.2022; 88(6): 2642.     CrossRef
  • Diabetes, Metformin and the Clinical Course of Covid-19: Outcomes, Mechanisms and Suggestions on the Therapeutic Use of Metformin
    Clifford J. Bailey, Mike Gwilt
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • The Role of Diabetes and Hyperglycemia on COVID-19 Infection Course—A Narrative Review
    Evangelia Tzeravini, Eleftherios Stratigakos, Chris Siafarikas, Anastasios Tentolouris, Nikolaos Tentolouris
    Frontiers in Clinical Diabetes and Healthcare.2022;[Epub]     CrossRef
  • Preadmission use of antidiabetic medications and mortality among patients with COVID-19 having type 2 diabetes: A meta-analysis
    Nam Nhat Nguyen, Dung Si Ho, Hung Song Nguyen, Dang Khanh Ngan Ho, Hung-Yuan Li, Chia-Yuan Lin, Hsiao-Yean Chiu, Yang-Ching Chen
    Metabolism.2022; 131: 155196.     CrossRef
  • Glucose-Lowering Agents and COVID-19
    Ah Reum Khang
    The Journal of Korean Diabetes.2022; 23(1): 1.     CrossRef
  • Impact of diabetes on COVID‐19 mortality and hospital outcomes from a global perspective: An umbrella systematic review and meta‐analysis
    Stavroula Kastora, Manisha Patel, Ben Carter, Mirela Delibegovic, Phyo Kyaw Myint
    Endocrinology, Diabetes & Metabolism.2022;[Epub]     CrossRef
  • The Association Between Antidiabetic Agents and Clinical Outcomes of COVID-19 Patients With Diabetes: A Bayesian Network Meta-Analysis
    Yidan Chen, Xingfei Lv, Sang Lin, Mohammad Arshad, Mengjun Dai
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Renin‐Angiotensin Aldosterone System Inhibitors and COVID‐19: A Systematic Review and Meta‐Analysis Revealing Critical Bias Across a Body of Observational Research
    Jordan Loader, Frances C. Taylor, Erik Lampa, Johan Sundström
    Journal of the American Heart Association.2022;[Epub]     CrossRef
  • Diabetes and SARS-CoV-2–Is There a Mutual Connection?
    Anna P. Jedrzejak, Edyta K. Urbaniak, Jadwiga A. Wasko, Natalia Ziojla, Malgorzata Borowiak
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • The relationship of age, sex and prothrombin time related to the severity and mortality of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis
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    F1000Research.2022; 11: 729.     CrossRef
  • Are lipid ratios and triglyceride-glucose index associated with critical care outcomes in COVID-19 patients?
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    PLOS ONE.2022; 17(8): e0272000.     CrossRef
  • Early glycaemic variability increases 28-day mortality and prolongs intensive care unit stay in critically ill patients with pneumonia
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    Annals of Medicine.2022; 54(1): 2724.     CrossRef
  • Dipeptidyl peptidase 4 inhibitors in COVID-19: Beyond glycemic control
    Niya Narayanan, Dukhabandhu Naik, Jayaprakash Sahoo, Sadishkumar Kamalanathan
    World Journal of Virology.2022; 11(6): 399.     CrossRef
  • Prevalencia de secuelas en pacientes con diabetes mellitus tipo 2 sobrevivientes al COVID-19
    Gianela M. Cancino-Castillo, Miguel A. Tresierra-Ayala, Jorge L. Campos-Reyna, Jaime Rosales-Rimache
    REVISTA MÉDICA VALLEJIANA/ Vallejian Medical Journal.2022; 11(2): 48.     CrossRef
  • Predictors of adverse in-hospital outcome and recovery in patients with diabetes mellitus and COVID-19 pneumonia in Iraq
    Hussein Nafakhi, Mohammed Alareedh, Karrar Al-Buthabhak, Foaad Shaghee, Ahmed Nafakhi, Samet Kasim
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2021; 15(1): 33.     CrossRef
  • Non-insulin anti-diabetic agents in patients with type 2 diabetes and COVID-19: A Critical Appraisal of Literature
    Awadhesh Kumar Singh, Ritu Singh, Banshi Saboo, Anoop Misra
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2021; 15(1): 159.     CrossRef
  • COVID-19 associated with diabetes and other noncommunicable diseases led to a global health crisis
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    Diabetes Research and Clinical Practice.2021; 171: 108587.     CrossRef
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    Journal of Endocrinological Investigation.2021; 44(7): 1379.     CrossRef
  • Prognostic bioindicators in severe COVID-19 patients
    L. Bergantini, E. Bargagli, M. d'Alessandro, R.M. Refini, P. Cameli, L. Galasso, C. Scapellato, F. Montagnani, S. Scolletta, F. Franchi, S. Valente, D. Bennett, G. Sebastiani, B. Frediani, F. Dotta
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    International Journal of Diabetes in Developing Countries.2021; 41(3): 383.     CrossRef
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    André J. Scheen
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    Frontiers in Pharmacology.2021;[Epub]     CrossRef
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    Timotius Ivan Hariyanto, Andree Kurniawan
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    Acta Diabetologica.2021; 58(8): 1101.     CrossRef
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    Progress in Neuro-Psychopharmacology and Biological Psychiatry.2021; 111: 110341.     CrossRef
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  • Is diabetes mellitus a wrongdoer to COVID-19 severity?
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    Diabetes Research and Clinical Practice.2021; 178: 108936.     CrossRef
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    Frontiers in Molecular Biosciences.2021;[Epub]     CrossRef
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    Diabetes Care.2021; 44(7): 1564.     CrossRef
  • The effect of metformin on mortality and severity in COVID-19 patients with diabetes mellitus
    Wenxing Yang, Xuehong Sun, Jun Zhang, Kui Zhang
    Diabetes Research and Clinical Practice.2021; 178: 108977.     CrossRef
  • Renin‐Angiotensin Aldosterone System Inhibitors in Primary Prevention and COVID‐19
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    Journal of the American Heart Association.2021;[Epub]     CrossRef
  • Factors influencing on development of COVID-19 pneumonia and association with oral anti-diabetic drugs in hospitalized patients with diabetes mellitus
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    Primary Care Diabetes.2021; 15(5): 806.     CrossRef
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    Experimental Gerontology.2021; 154: 111507.     CrossRef
  • Classical and Counter-Regulatory Renin–Angiotensin System: Potential Key Roles in COVID-19 Pathophysiology
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    CJC Open.2021; 3(8): 1060.     CrossRef
  • Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis
    Yin Li, Xue Yang, Peijing Yan, Tong Sun, Zhi Zeng, Sheyu Li
    Frontiers in Medicine.2021;[Epub]     CrossRef
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    BMC Medicine.2021;[Epub]     CrossRef
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    Endocrinology and Metabolism.2021; 36(4): 757.     CrossRef
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    Endocrinology and Metabolism.2021; 36(4): 800.     CrossRef
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    Clinical Cardiology.2020; 43(12): 1478.     CrossRef
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Review
Guideline/Fact Sheet
Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association
Byung-Wan Lee, Yong-ho Lee, Cheol-Young Park, Eun-Jung Rhee, Won-Young Lee, Nan-Hee Kim, Kyung Mook Choi, Keun-Gyu Park, Yeon-Kyung Choi, Bong-Soo Cha, Dae Ho Lee, Korean Diabetes Association (KDA) Fatty Liver Research Group
Diabetes Metab J. 2020;44(3):382-401.   Published online May 11, 2020
DOI: https://doi.org/10.4093/dmj.2020.0010
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AbstractAbstract PDFPubReader   

This clinical practice position statement, a product of the Fatty Liver Research Group of the Korean Diabetes Association, proposes recommendations for the diagnosis, progression and/or severity assessment, management, and follow-up of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Patients with both T2DM and NAFLD have an increased risk of non-alcoholic steatohepatitis (NASH) and fibrosis and a higher risk of cardiovascular diseases and diabetic complications compared to those without NAFLD. With regards to the evaluation of patients with T2DM and NAFLD, ultrasonography-based stepwise approaches using noninvasive biomarker models such as fibrosis-4 or the NAFLD fibrosis score as well as imaging studies such as vibration-controlled transient elastography with controlled attenuation parameter or magnetic resonance imaging-proton density fat fraction are recommended. After the diagnosis of NAFLD, the stage of fibrosis needs to be assessed appropriately. For management, weight reduction achieved by lifestyle modification has proven beneficial and is recommended in combination with antidiabetic agent(s). Evidence that some antidiabetic agents improve NAFLD/NASH with fibrosis in patients with T2DM is emerging. However, there are currently no definite pharmacologic treatments for NAFLD in patients with T2DM. For specific cases, bariatric surgery may be an option if indicated.

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  • A combined extract containing Schisandra chinensis (SCE) reduced hepatic triglyceride accumulation in rats fed a high-sucrose diet
    Haneul Lee, Eun Young Kang, Joowon Lee, Yejin Kim, Sumin Kang, Hayoon Kim, Hyun Kyung Kim, Gyoungok Gang, Sang-gil Lee, Cao Lei, Gwang-woong Go
    Food Science and Biotechnology.2024; 33(6): 1449.     CrossRef
  • Association of non-alcoholic fatty liver disease with cardiovascular disease and all cause death in patients with type 2 diabetes mellitus: nationwide population based study
    Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park
    BMJ.2024; : e076388.     CrossRef
  • Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Clinical and Experimental Perspective
    Inha Jung, Dae-Jeong Koo, Won-Young Lee
    Diabetes & Metabolism Journal.2024; 48(3): 327.     CrossRef
  • Association between urinary polycyclic aromatic hydrocarbons and risk of metabolic associated fatty liver disease
    Minzhen Wang, Shaoyan Tang, Lulu Zhang, Yamin Zhao, Yindi Peng, Shan zheng, Zanchao Liu
    International Archives of Occupational and Environmental Health.2024;[Epub]     CrossRef
  • Risk Scores for Prediction of Major Cardiovascular Events in Non-Alcoholic Fatty Liver Disease: A No Man’s Land?
    Liliana Gheorghe, Roxana Nemteanu, Andreea Clim, Gina Eosefina Botnariu, Irina Iuliana Costache, Alina Plesa
    Life.2023; 13(4): 857.     CrossRef
  • Increased expression of sodium-glucose cotransporter 2 and O-GlcNAcylation in hepatocytes drives non-alcoholic steatohepatitis
    Hye Jin Chun, Eun Ran Kim, Minyoung Lee, Da Hyun Choi, Soo Hyun Kim, Eugene Shin, Jin-Hong Kim, Jin Won Cho, Dai Hoon Han, Bong-Soo Cha, Yong-ho Lee
    Metabolism.2023; 145: 155612.     CrossRef
  • Association between fatty liver index and risk of end-stage renal disease stratified by kidney function in patients with type 2 diabetes: A nationwide population-based study
    Goh Eun Chung, Kyungdo Han, Kyu-Na Lee, Jung Ho Bae, Sun Young Yang, Su-Yeon Choi, Jeong Yoon Yim, Nam Ju Heo
    Diabetes & Metabolism.2023; 49(4): 101454.     CrossRef
  • Comparison of glucagon-like peptide-1 receptor agonists and thiazolidinediones on treating nonalcoholic fatty liver disease: A network meta-analysis
    Min Jeong Park, Hayeon Kim, Myeong Gyu Kim, Kyungim Kim
    Clinical and Molecular Hepatology.2023; 29(3): 693.     CrossRef
  • Histological analysis of hypoglycemic agents on liver fibrosis in patients with non-alcoholic fatty liver disease: a systematic review
    Qingxing Xie, Xiaohui Pan, Xinyue Zhang, Jinfang Ma, Ge Peng, Nanwei Tong
    Chinese Medical Journal.2023; 136(16): 2014.     CrossRef
  • Hepatotropc effects of glucose-lowering drugs: non-alcoholic fatty liver disease in focus
    E. V. Uzhakova, Z. E. Zshanko, E. N. Smirnova
    Experimental and Clinical Gastroenterology.2023; (6): 121.     CrossRef
  • Complementary effects of dapagliflozin and lobeglitazone on metabolism in a diet-induced obese mouse model
    Yun Kyung Lee, Tae Jung Oh, Ji In Lee, Bo Yoon Choi, Hyen Chung Cho, Hak Chul Jang, Sung Hee Choi
    European Journal of Pharmacology.2023; 957: 175946.     CrossRef
  • Hepatic T-cell senescence and exhaustion are implicated in the progression of fatty liver disease in patients with type 2 diabetes and mouse model with nonalcoholic steatohepatitis
    Byeong Chang Sim, Yea Eun Kang, Sun Kyoung You, Seong Eun Lee, Ha Thi Nga, Ho Yeop Lee, Thi Linh Nguyen, Ji Sun Moon, Jingwen Tian, Hyo Ju Jang, Jeong Eun Lee, Hyon-Seung Yi
    Cell Death & Disease.2023;[Epub]     CrossRef
  • 2023 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
    Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Nan Hee Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, YoonJu Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang Youl Rhee, Hae J
    Diabetes & Metabolism Journal.2023; 47(5): 575.     CrossRef
  • Circ_0004535/miR-1827/CASP8 network involved in type 2 diabetes mellitus with nonalcoholic fatty liver disease
    Min Li, Ai Zeng, Xinle Tang, Hui Xu, Wei Xiong, Yanying Guo
    Scientific Reports.2023;[Epub]     CrossRef
  • Stratification by obesity class, rather than age, can identify a higher percent of children at risk for non‐alcoholic fatty liver disease and metabolic dysfunction
    Aurelia Radulescu, Adam J. Dugan, Mary Killian, Suzanna L. Attia, Marialena Mouzaki, George J. Fuchs, Rohit Kohli, Henrietta Bada, Philip A. Kern, Samir Softic
    Pediatric Obesity.2022;[Epub]     CrossRef
  • Renal Tubular Damage Marker, Urinary N-acetyl-β-D-Glucosaminidase, as a Predictive Marker of Hepatic Fibrosis in Type 2 Diabetes Mellitus
    Hae Kyung Kim, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
    Diabetes & Metabolism Journal.2022; 46(1): 104.     CrossRef
  • Dulaglutide Ameliorates Palmitic Acid-Induced Hepatic Steatosis by Activating FAM3A Signaling Pathway
    Jinmi Lee, Seok-Woo Hong, Min-Jeong Kim, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
    Endocrinology and Metabolism.2022; 37(1): 74.     CrossRef
  • State-of-the-Art Overview of the Pharmacological Treatment of Non-Alcoholic Steatohepatitis
    Yongin Cho, Yong-ho Lee
    Endocrinology and Metabolism.2022; 37(1): 38.     CrossRef
  • Ezetimibe combination therapy with statin for non-alcoholic fatty liver disease: an open-label randomized controlled trial (ESSENTIAL study)
    Yongin Cho, Hyungjin Rhee, Young-eun Kim, Minyoung Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Jin-Young Choi, Yong-ho Lee
    BMC Medicine.2022;[Epub]     CrossRef
  • Obesity is an important determinant of severity in newly defined metabolic dysfunction-associated fatty liver disease
    Ji Hye Huh, Kwang Joon Kim, Seung Up Kim, Bong-Soo Cha, Byung-Wan Lee
    Hepatobiliary & Pancreatic Diseases International.2022; 21(3): 241.     CrossRef
  • Anti-Obesity and Anti-Hyperglycemic Effects of Meretrix lusoria Protamex Hydrolysate in ob/ob Mice
    Min Ju Kim, Ramakrishna Chilakala, Hee Geun Jo, Seung-Jae Lee, Dong-Sung Lee, Sun Hee Cheong
    International Journal of Molecular Sciences.2022; 23(7): 4015.     CrossRef
  • The associations of hepatic steatosis and fibrosis using fatty liver index and BARD score with cardiovascular outcomes and mortality in patients with new-onset type 2 diabetes: a nationwide cohort study
    Jiyun Park, Gyuri Kim, Bong-Sung Kim, Kyung-Do Han, So Yoon Kwon, So Hee Park, You-Bin Lee, Sang-Man Jin, Jae Hyeon Kim
    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • Cumulative Exposure to High γ-Glutamyl Transferase Level and Risk of Diabetes: A Nationwide Population-Based Study
    Ji-Yeon Park, Kyungdo Han, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee
    Endocrinology and Metabolism.2022; 37(2): 272.     CrossRef
  • SGLT-2 inhibitors and GLP-1 receptor agonists in metabolic dysfunction-associated fatty liver disease
    Jun Sung Moon, Jun Hwa Hong, Yong Jin Jung, Ele Ferrannini, Michael A. Nauck, Soo Lim
    Trends in Endocrinology & Metabolism.2022; 33(6): 424.     CrossRef
  • Plasma Aldo-Keto Reductase Family 1 Member B10 as a Biomarker Performs Well in the Diagnosis of Nonalcoholic Steatohepatitis and Fibrosis
    Aron Park, Seung Joon Choi, Sungjin Park, Seong Min Kim, Hye Eun Lee, Minjae Joo, Kyoung Kon Kim, Doojin Kim, Dong Hae Chung, Jae Been Im, Jaehun Jung, Seung Kak Shin, Byung-Chul Oh, Cheolsoo Choi, Seungyoon Nam, Dae Ho Lee
    International Journal of Molecular Sciences.2022; 23(9): 5035.     CrossRef
  • Chinese Herbal Medicine for Type 2 Diabetes Mellitus With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
    Sihan Peng, Lu Liu, Ziyan Xie, Xiyu Zhang, Chunguang Xie, Sha Ye, Xiangeng Zhang, Xiaoli Liang, Hongyan Wang, Ya Liu
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Non-alcoholic fatty liver disease and sarcopenia is associated with the risk of albuminuria independent of insulin resistance, and obesity
    Eugene Han, Mi Kyung Kim, Seung-Soon Im, Byoung Kuk Jang, Hye Soon Kim
    Journal of Diabetes and its Complications.2022; 36(8): 108253.     CrossRef
  • Extra-Glycemic Effects of Anti-Diabetic Medications: Two Birds with One Stone?
    Eun-Jung Rhee
    Endocrinology and Metabolism.2022; 37(3): 415.     CrossRef
  • Plasma Metabolomics and Machine Learning-Driven Novel Diagnostic Signature for Non-Alcoholic Steatohepatitis
    Moongi Ji, Yunju Jo, Seung Joon Choi, Seong Min Kim, Kyoung Kon Kim, Byung-Chul Oh, Dongryeol Ryu, Man-Jeong Paik, Dae Ho Lee
    Biomedicines.2022; 10(7): 1669.     CrossRef
  • Association Between DPP4 Inhibitor Use and the Incidence of Cirrhosis, ESRD, and Some Cancers in Patients With Diabetes
    Yewon Na, Soo Wan Kim, Ie Byung Park, Soo Jung Choi, Seungyoon Nam, Jaehun Jung, Dae Ho Lee
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(11): 3022.     CrossRef
  • Nonalcoholic fatty liver disease is associated with early left ventricular diastolic dysfunction in patients with type 2 diabeteS
    Walaa Sheba, Eman Morsy, Salah Altahan, Mona Ayaad, Sameh A. Lashen
    Alexandria Journal of Medicine.2022; 58(1): 117.     CrossRef
  • The association between changes in hepatic steatosis and hepatic fibrosis with cardiovascular outcomes and mortality in patients with New-Onset type 2 Diabetes: A nationwide cohort study
    Jiyun Park, Gyuri Kim, Bong-Sung Kim, Kyung-Do Han, So Yoon Kwon, So Hee Park, You-Bin Lee, Sang-Man Jin, Jae Hyeon Kim
    Diabetes Research and Clinical Practice.2022; 194: 110191.     CrossRef
  • Advanced Liver Fibrosis Is Associated with Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease (Diabetes Metab J 2022;46:630-9)
    Ji Hye Huh
    Diabetes & Metabolism Journal.2022; 46(6): 953.     CrossRef
  • The association of fatty liver index and BARD score with all-cause and cause-specific mortality in patients with type 2 diabetes mellitus: a nationwide population-based study
    Goh Eun Chung, Su-Min Jeong, Eun Ju Cho, Ji Won Yoon, Jeong-Ju Yoo, Yuri Cho, Kyu-na Lee, Dong Wook Shin, Yoon Jun Kim, Jung-Hwan Yoon, Kyungdo Han, Su Jong Yu
    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • Non-Albumin Proteinuria (NAP) as a Complementary Marker for Diabetic Kidney Disease (DKD)
    Jaehyun Bae, Young Jun Won, Byung-Wan Lee
    Life.2021; 11(3): 224.     CrossRef
  • Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: Diagnosis and Treatment
    Sook Jung Lee, Byung-Wan Lee
    The Journal of Korean Diabetes.2021; 22(1): 38.     CrossRef
  • Non-alcoholic fatty liver disease
    Elizabeth E Powell, Vincent Wai-Sun Wong, Mary Rinella
    The Lancet.2021; 397(10290): 2212.     CrossRef
  • Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway
    In-Jin Cho, Da-Hee Oh, Jin Yoo, You-Cheol Hwang, Kyu Jeung Ahn, Ho-Yeon Chung, Soung Won Jeong, Ju-Young Moon, Sang-Ho Lee, Sung-Jig Lim, In-Kyung Jeong
    Scientific Reports.2021;[Epub]     CrossRef
  • Patient Management in Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus
    A. E. Bagriy, A. D. Zubov, M. V. Khomenko, E. S. Mikhailichenko, E. A. Pylaeva, N. A. Khaustova, E. V. Bryukhovetskaya
    Russian Journal of Gastroenterology, Hepatology, Coloproctology.2021; 31(2): 14.     CrossRef
  • Liver Fibrosis Indices for the Prediction of Mortality in Korean Subjects: A 16-Year Prospective Cohort Study
    Tae Jung Oh, Kyuho Kim, Jae Hoon Moon, Sung Hee Choi, Nam H Cho, Hak Chul Jang
    Journal of the Endocrine Society.2021;[Epub]     CrossRef
  • Reduced Rank Regression-Derived Dietary Patterns Related to the Fatty Liver Index and Associations with Type 2 Diabetes Mellitus among Ghanaian Populations under Transition: The RODAM Study
    Tracy Bonsu Osei, Anne-Marieke van Dijk, Sjoerd Dingerink, Felix Patience Chilunga, Erik Beune, Karlijn Anna Catharina Meeks, Silver Bahendeka, Matthias Bernd Schulze, Charles Agyemang, Mary Nicolaou, Adriaan Georgius Holleboom, Ina Danquah
    Nutrients.2021; 13(11): 3679.     CrossRef
  • Efficacy and Safety of GLP-1 Receptor Agonists in Patients With Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
    Yuan Zhu, Jiao Xu, Dong Zhang, Xingyu Mu, Yi Shi, Shangtao Chen, Zengxiang Wu, Shuangqing Li
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Liver fibrosis indices are related to diabetic peripheral neuropathy in individuals with type 2 diabetes
    Kyuho Kim, Tae Jung Oh, Hyen Chung Cho, Yun Kyung Lee, Chang Ho Ahn, Bo Kyung Koo, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang
    Scientific Reports.2021;[Epub]     CrossRef
  • Evaluation of Grapefruit Juice in terms of Interleukin 18 Gene Expression in Rats with Fatty Liver and Healthy Rats
    Simin Bahmanpoor, Noosha Zia-Jahromi
    journal of ilam university of medical sciences.2021; 29(4): 74.     CrossRef
Brief Report
Drug/Regimen
Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
Mi-Jin Kim, Na-young Kim, Yun-A Jung, Seunghyeong Lee, Gwon-Soo Jung, Jung-Guk Kim, In-Kyu Lee, Sungwoo Lee, Yeon-Kyung Choi, Keun-Gyu Park
Diabetes Metab J. 2020;44(1):186-192.   Published online October 31, 2019
DOI: https://doi.org/10.4093/dmj.2018.0271
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AbstractAbstract PDFSupplementary MaterialPubReader   

Renal fibrosis is considered to be the final common outcome of chronic kidney disease. Dipeptidyl peptidase-4 (DPP-4) inhibitors have demonstrated protective effects against diabetic kidney disease. However, the anti-fibrotic effect of evogliptin, a DPP-4 inhibitor, has not been studied. Here, we report the beneficial effects of evogliptin on unilateral ureteral obstruction (UUO)-induced renal fibrosis in mice. Evogliptin attenuated UUO-induced renal atrophy and tubulointerstitial fibrosis. Immunohistochemistry and Western blotting demonstrated that evogliptin treatment inhibits pro-fibrotic gene expressions and extracellular matrix production. In vitro findings showed that the beneficial effects of evogliptin on renal fibrosis are mediated by inhibition of the transforming growth factor-β/Smad3 signaling pathway. The present study demonstrates that evogliptin is protective against UUO-induced renal fibrosis, suggesting that its clinical applications could extend to the treatment of kidney disease of non-diabetic origin.

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  • Targeting cluster of differentiation 26 / dipeptidyl peptidase 4 (CD26/DPP4) in organ fibrosis
    Birte Ohm, Isabelle Moneke, Wolfgang Jungraithmayr
    British Journal of Pharmacology.2023; 180(22): 2846.     CrossRef
  • Linagliptin ameliorates pulmonary fibrosis in systemic sclerosis mouse model via inhibition of endothelial-to-mesenchymal transition
    Biwei Pei, Na Zhang, Tingting Pang, Gengyun Sun
    Molecular and Cellular Biochemistry.2022; 477(4): 995.     CrossRef
  • Association Between DPP4 Inhibitor Use and the Incidence of Cirrhosis, ESRD, and Some Cancers in Patients With Diabetes
    Yewon Na, Soo Wan Kim, Ie Byung Park, Soo Jung Choi, Seungyoon Nam, Jaehun Jung, Dae Ho Lee
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(11): 3022.     CrossRef
  • Evogliptin Directly Inhibits Inflammatory and Fibrotic Signaling in Isolated Liver Cells
    Hye-Young Seo, So-Hee Lee, Eugene Han, Jae Seok Hwang, Sol Han, Mi Kyung Kim, Byoung Kuk Jang
    International Journal of Molecular Sciences.2022; 23(19): 11636.     CrossRef
  • Optimization and validation of a fluorogenic dipeptidyl peptidase 4 enzymatic assay in human plasma
    Hyunyee Yoon, Su Hee Cho, Yu Rim Seo, Kyung-Sang Yu, Sung Sup Park, Moon Jung Song
    Analytical Biochemistry.2021; 612: 113952.     CrossRef
  • Use of Anti-Diabetic Agents in Non-Diabetic Kidney Disease: From Bench to Bedside
    Sungjin Chung, Gheun-Ho Kim
    Life.2021; 11(5): 389.     CrossRef
  • Targeting Dermal Fibroblast Subtypes in Antifibrotic Therapy: Surface Marker as a Cellular Identity or a Functional Entity?
    Xin Huang, Yimin Khoong, Chengyao Han, Dai Su, Hao Ma, Shuchen Gu, Qingfeng Li, Tao Zan
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • Efficacy and safety of evogliptin treatment in patients with type 2 diabetes: A multicentre, active‐controlled, randomized, double‐blind study with open‐label extension (the EVERGREEN study)
    Gyuri Kim, Soo Lim, Hyuk‐Sang Kwon, Ie B. Park, Kyu J. Ahn, Cheol‐Young Park, Su K. Kwon, Hye S. Kim, Seok W. Park, Sin G. Kim, Min K. Moon, Eun S. Kim, Choon H. Chung, Kang S. Park, Mikyung Kim, Dong J. Chung, Chang B. Lee, Tae H. Kim, Moon‐Kyu Lee
    Diabetes, Obesity and Metabolism.2020; 22(9): 1527.     CrossRef
  • Effect of Switching from Linagliptin to Teneligliptin Dipeptidyl Peptidase-4 Inhibitors in Older Patients with Type 2 Diabetes Mellitus


    Eugene Han, Minyoung Lee, Yong-ho Lee, Hye Soon Kim, Byung-wan Lee, Bong-Soo Cha, Eun Seok Kang
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 4113.     CrossRef
  • Efficacy and safety of novel dipeptidyl-peptidase-4 inhibitor evogliptin in the management of type 2 diabetes mellitus: A meta-analysis
    Deep Dutta, Saptarshi Bhattacharya, Aishwarya Krishnamurthy, LokeshKumar Sharma, Meha Sharma
    Indian Journal of Endocrinology and Metabolism.2020; 24(5): 434.     CrossRef
Short Communication
Epidemiology
Low-Normal Free Thyroxine Levels in Euthyroid Male Are Associated with Prediabetes
Sung Woo Kim, Jae-Han Jeon, Jun Sung Moon, Eon Ju Jeon, Mi-Kyung Kim, In-Kyu Lee, Jung Beom Seo, Keun-Gyu Park
Diabetes Metab J. 2019;43(5):718-726.   Published online March 19, 2019
DOI: https://doi.org/10.4093/dmj.2018.0222
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AbstractAbstract PDFSupplementary MaterialPubReader   

Abnormal thyroid function is associated with impaired glucose homeostasis. This study aimed to determine whether free thyroxine (FT4) influences the prevalence of prediabetes in euthyroid subjects using a cross-sectional survey derived from the Korea National Health and Nutrition Examination Survey, conducted between 2013 and 2015. We studied 2,399 male participants of >20 years of age who were euthyroid and non-diabetic. Prediabetic participants had lower FT4 concentrations than those without prediabetes, but their thyrotropin concentrations were similar. We stratified the population into tertiles according to FT4 concentration. After adjusting for multiple confounding factors, glycosylated hemoglobin (HbA1c) levels significantly decreased with increasing FT4 tertile, whereas fasting plasma glucose (FPG) levels were not associated with FT4 tertiles (HbA1c, P<0.01 in T3 vs. T1; FPG, P=0.489 in T3 vs. T1). The prevalence of prediabetes was significantly higher in T1 (odds ratio, 1.426; 95% confidence interval, 1.126 to 1.806; P<0.01) than in T3. In conclusion, subjects with low-normal serum FT4 had high HbA1c and were more likely to have prediabetes. These results suggest that low FT4 concentration is a risk factor for prediabetes in male, even when thyroid function is within the normal range.

Original Articles
Complications
Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome
Jung Beom Seo, Yeon-Kyung Choi, Hye-In Woo, Yun-A Jung, Sungwoo Lee, Seunghyeong Lee, Mihyang Park, In-Kyu Lee, Gwon-Soo Jung, Keun-Gyu Park
Diabetes Metab J. 2019;43(6):830-839.   Published online March 5, 2019
DOI: https://doi.org/10.4093/dmj.2018.0181
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AbstractAbstract PDFPubReader   
Background

The hypoglycemic drugs dipeptidyl peptidase-4 (DPP-4) inhibitors have proven protective effects on diabetic kidney disease, including renal fibrosis. Although NOD-like receptor protein 3 (NLRP3) inflammasome activation is known to play an important role in the progression of renal fibrosis, the impact of DPP-4 inhibition on NLRP3-mediated inflammation while ameliorating renal fibrosis has not been fully elucidated. Here, we report that the renoprotective effect of gemigliptin is associated with a reduction in NLRP3-mediated inflammation in a murine model of renal fibrosis.

Methods

We examined the effects of gemigliptin on renal tubulointerstitial fibrosis induced in mice by unilateral ureteral obstruction (UUO). Using immunohistochemical and Western blot analysis, we quantitated components of the NLRP3 inflammasome in kidneys with and without gemigliptin treatment, and in vitro in human kidney tubular epithelial human renal proximal tubule cells (HK-2) cells, we further analyzed the effect of gemigliptin on transforming growth factor-β (TGF-β)-stimulated production of profibrotic proteins.

Results

Immunohistological examination revealed that gemigliptin ameliorated UUO-induced tubular atrophy and renal fibrosis. Gemigliptin-treated kidneys showed a reduction in levels of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), caspase-1, and interleukin-1β, which had all been markedly increased by UUO. In line with the in vivo results, TGF-β markedly increased NLRP3 inflammasome markers, which were attenuated by gemigliptin treatment. Furthermore, gemigliptin treatment attenuated phosphorylated nuclear factor-κB levels, which had been increased in the UUO kidney as well as in TGF-β-treated cultured renal cells.

Conclusion

The present study shows that activation of the NLRP3 inflammasome contributes to UUO-induced renal fibrosis and the renoprotective effect of gemigliptin is associated with attenuation of NLRP3 inflammasome activation.

Citations

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  • Novel pharmacological interventions for diabetic kidney disease
    Seng Kiong Tan, Jairo A. Pinzon-Cortes, Mark E. Cooper
    Current Opinion in Nephrology & Hypertension.2024; 33(1): 13.     CrossRef
  • Integrated analysis reveals crosstalk between pyroptosis and immune regulation in renal fibrosis
    Fengxia Bai, Longchao Han, Jifeng Yang, Yuxiu Liu, Xiangmeng Li, Yaqin Wang, Ruijian Jiang, Zhaomu Zeng, Yan Gao, Haisong Zhang
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Di (2-ethylhexyl) phthalate and polystyrene microplastics co-exposure caused oxidative stress to activate NF-κB/NLRP3 pathway aggravated pyroptosis and inflammation in mouse kidney
    Shanshan Li, Xuedie Gu, Muyue Zhang, Qihang Jiang, Tong Xu
    Science of The Total Environment.2024; 926: 171817.     CrossRef
  • Fluorofenidone attenuates renal fibrosis by inhibiting lysosomal cathepsin‑mediated NLRP3 inflammasome activation
    Linfeng Zheng, Wenjuan Mei, Jing Zhou, Xin Wei, Zhijuan Huang, Xiaozhen Lin, Li Zhang, Wei Liu, Qian Wu, Jinhong Li, Yan Yan
    Experimental and Therapeutic Medicine.2024;[Epub]     CrossRef
  • HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome
    Jialin Li, Qisheng Lin, Xinghua Shao, Shu Li, Xuying Zhu, Jingkui Wu, Shan Mou, Leyi Gu, Qin Wang, Minfang Zhang, Kaiqi Zhang, Jiayue Lu, Zhaohui Ni
    Cell Death & Disease.2023;[Epub]     CrossRef
  • Pyroptosis in renal inflammation and fibrosis: current knowledge and clinical significance
    Ya Liu, Haibo Lei, Wenyou Zhang, Qichang Xing, Renzhu Liu, Shiwei Wu, Zheng Liu, Qingzi Yan, Wencan Li, Xiang Liu, Yixiang Hu
    Cell Death & Disease.2023;[Epub]     CrossRef
  • Tubular injury in diabetic kidney disease: molecular mechanisms and potential therapeutic perspectives
    Yu Wang, Mingyue Jin, Chak Kwong Cheng, Qiang Li
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Hederagenin inhibits high glucose‐induced fibrosis in human renal cells by suppression of NLRP3 inflammasome activation through reducing cathepsin B expression
    Guohua Yang, Wang Yang, Hairong Jiang, Qing Yi, Wei Ma
    Chemical Biology & Drug Design.2023; 102(6): 1409.     CrossRef
  • Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis
    Rikke Nørregaard, Henricus A. M. Mutsaers, Jørgen Frøkiær, Tae-Hwan Kwon
    Physiological Reviews.2023; 103(4): 2847.     CrossRef
  • Adenine model of chronic renal failure in rats to determine whether MCC950, an NLRP3 inflammasome inhibitor, is a renopreventive
    Mahmoud S. Sabra, Fahmy K. Hemida, Essmat A. H. Allam
    BMC Nephrology.2023;[Epub]     CrossRef
  • Gut microbiota dysbiosis promotes age-related atrial fibrillation by lipopolysaccharide and glucose-induced activation of NLRP3-inflammasome
    Yun Zhang, Song Zhang, Bolin Li, Yingchun Luo, Yongtai Gong, Xuexin Jin, Jiawei Zhang, Yun Zhou, Xiaozhen Zhuo, Zixi Wang, Xinbo Zhao, Xuejie Han, Yunlong Gao, Hui Yu, Desen Liang, Shiqi Zhao, Danghui Sun, Dingyu Wang, Wei Xu, Guangjin Qu, Wanlan Bo, Dan
    Cardiovascular Research.2022; 118(3): 785.     CrossRef
  • The NLRP3 inflammasome in fibrosis and aging: The known unknowns
    Yanqing Liu, Xuezeng Xu, Wangrui Lei, Yuxuan Hou, Yan Zhang, Ran Tang, Zhi Yang, Ye Tian, Yanli Zhu, Changyu Wang, Chao Deng, Shaofei Zhang, Yang Yang
    Ageing Research Reviews.2022; 79: 101638.     CrossRef
  • Research progress of endothelial‐mesenchymal transition in diabetic kidney disease
    Ying Chen, Hang Zou, Hongwei Lu, Hong Xiang, Shuhua Chen
    Journal of Cellular and Molecular Medicine.2022; 26(12): 3313.     CrossRef
  • Exploring the mechanism of Shendi Bushen capsule in anti-renal fibrosis using metabolomics theory and network analysis
    Tianwei Meng, Hong Chang, Hongyu Meng
    Molecular Omics.2022; 18(9): 873.     CrossRef
  • Gemigliptin suppresses salivary dysfunction in streptozotocin-induced diabetic rats
    Wan Seok Kang, Woo Kwon Jung, Su-Bin Park, Hyung Rae Kim, Junghyun Kim
    Biomedicine & Pharmacotherapy.2021; 137: 111297.     CrossRef
  • Long‐Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats
    Edwin K. Jackson, Zaichuan Mi, Delbert G. Gillespie, Dongmei Cheng, Stevan P. Tofovic
    Journal of the American Heart Association.2021;[Epub]     CrossRef
  • Disulfiram inhibits inflammation and fibrosis in a rat unilateral ureteral obstruction model by inhibiting gasdermin D cleavage and pyroptosis
    Yu Zhang, Ruicheng Zhang, Xiaohu Han
    Inflammation Research.2021; 70(5): 543.     CrossRef
  • Inflammasome as an Effective Platform for Fibrosis Therapy
    Ting-Ting Chen, Feng Xiao, Nan Li, Shan Shan, Meng Qi, Zi-Ying Wang, Sheng-Nan Zhang, Wei Wei, Wu-Yi Sun
    Journal of Inflammation Research.2021; Volume 14: 1575.     CrossRef
  • Targeting Dermal Fibroblast Subtypes in Antifibrotic Therapy: Surface Marker as a Cellular Identity or a Functional Entity?
    Xin Huang, Yimin Khoong, Chengyao Han, Dai Su, Hao Ma, Shuchen Gu, Qingfeng Li, Tao Zan
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • Linagliptin Protects against Endotoxin-Induced Acute Kidney Injury in Rats by Decreasing Inflammatory Cytokines and Reactive Oxygen Species
    Tsung-Jui Wu, Yi-Jen Hsieh, Chia-Wen Lu, Chung-Jen Lee, Bang-Gee Hsu
    International Journal of Molecular Sciences.2021; 22(20): 11190.     CrossRef
  • Psidium guajava Flavonoids Prevent NLRP3 Inflammasome Activation and Alleviate the Pancreatic Fibrosis in a Chronic Pancreatitis Mouse Model
    Guixian Zhang, Liming Tang, Hongbin Liu, Dawei Liu, Manxue Wang, Jun Cai, Weijun Liu, Wei Nie, Yi Zhang, Xiaomeng Yu
    The American Journal of Chinese Medicine.2021; 49(08): 2001.     CrossRef
  • Effect and Regulation of the NLRP3 Inflammasome During Renal Fibrosis
    Hong Zhang, Zhengchao Wang
    Frontiers in Cell and Developmental Biology.2020;[Epub]     CrossRef
  • Zhen-Wu-Tang Protects IgA Nephropathy in Rats by Regulating Exosomes to Inhibit NF-κB/NLRP3 Pathway
    Honglian Li, Ruirui Lu, Yu Pang, Jicheng Li, Yiwen Cao, Hongxin Fu, Guoxing Fang, Qiuhe Chen, Bihao Liu, Junbiao Wu, Yuan Zhou, Jiuyao Zhou
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • Protective effect of exogenous hydrogen sulfide on diaphragm muscle fibrosis in streptozotocin-induced diabetic rats
    Rui Yang, Qiang Jia, Yan Li, Shomaila Mehmood
    Experimental Biology and Medicine.2020; 245(14): 1280.     CrossRef
Islet Studies and Transplantation
Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5
Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Jae-Han Jeon, Nam Doo Kim, Keun-Gyu Park, Kyu Chang Won, Jaechan Leem, In-Kyu Lee
Diabetes Metab J. 2019;43(2):192-205.   Published online January 16, 2019
DOI: https://doi.org/10.4093/dmj.2018.0052
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AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Chronic hyperglycemia has deleterious effects on pancreatic β-cell function and turnover. Recent studies support the view that cyclin-dependent kinase 5 (CDK5) plays a role in β-cell failure under hyperglycemic conditions. However, little is known about how CDK5 impair β-cell function. Myricetin, a natural flavonoid, has therapeutic potential for the treatment of type 2 diabetes mellitus. In this study, we examined the effect of myricetin on high glucose (HG)-induced β-cell apoptosis and explored the relationship between myricetin and CDK5.

Methods

To address this question, we subjected INS-1 cells and isolated rat islets to HG conditions (30 mM) in the presence or absence of myricetin. Docking studies were conducted to validate the interaction between myricetin and CDK5. Gene expression and protein levels of endoplasmic reticulum (ER) stress markers were measured by real-time reverse transcription polymerase chain reaction and Western blot analysis.

Results

Activation of CDK5 in response to HG coupled with the induction of ER stress via the down regulation of sarcoendoplasmic reticulum calcium ATPase 2b (SERCA2b) gene expression and reduced the nuclear accumulation of pancreatic duodenal homeobox 1 (PDX1) leads to β-cell apoptosis. Docking study predicts that myricetin inhibit CDK5 activation by direct binding in the ATP-binding pocket. Myricetin counteracted the decrease in the levels of PDX1 and SERCA2b by HG. Moreover, myricetin attenuated HG-induced apoptosis in INS-1 cells and rat islets and reduce the mitochondrial dysfunction by decreasing reactive oxygen species production and mitochondrial membrane potential (Δψm) loss.

Conclusion

Myricetin protects the β-cells against HG-induced apoptosis by inhibiting ER stress, possibly through inactivation of CDK5 and consequent upregulation of PDX1 and SERCA2b.

Citations

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  • Profiling of secondary metabolite and evaluation of anti-diabetic potency of Crotalaria quinquefolia (L): In-vitro, in-vivo, and in-silico approaches
    Nazmun Nahar, Md. Nazmul Hasan Zilani, Partha Biswas, Md. Morsaline Billah, Shabana Bibi, Norah A. Albekairi, Abdulrahman Alshammari, Md. Nazmul Hasan
    Saudi Pharmaceutical Journal.2024; 32(1): 101887.     CrossRef
  • Mitochondrial aldehyde dehydrogenase-2 coordinates the hydrogen sulfide - AMPK axis to attenuate high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system
    Udayakumar Karunakaran, Suma Elumalai, Seung Min Chung, Kathrin Maedler, Kyu Chang Won, Jun Sung Moon
    Redox Biology.2024; 69: 102994.     CrossRef
  • Network-based identification and mechanism exploration of active ingredients against Alzheimer’s disease via targeting endoplasmic reticulum stress from traditional chinese medicine
    Zhao Dai, Tian Hu, Junwen Wei, Xue Wang, Chuipu Cai, Yong Gu, Yunhui Hu, Wenjia Wang, Qihui Wu, Jiansong Fang
    Computational and Structural Biotechnology Journal.2024; 23: 506.     CrossRef
  • Myricetin as a Promising Flavonoid with Multitargeted Biological Activity
    A.S. Chiriapkin
    Juvenis Scientia.2024; 10(1): 5.     CrossRef
  • Naturally occurring small molecules with dual effect upon inflammatory signaling pathways and endoplasmic reticulum stress response
    Daniela Correia da Silva, Patrícia Valentão, David M. Pereira
    Journal of Physiology and Biochemistry.2024; 80(2): 421.     CrossRef
  • Immunopeptidome mining reveals a novel ERS-induced target in T1D
    Lina Wang, Shushu Yang, Gaohui Zhu, Jie Li, Gang Meng, Xiaoling Chen, Mengjun Zhang, Shufeng Wang, Xiangqian Li, Yu Pan, Yi Huang, Li Wang, Yuzhang Wu
    Cellular & Molecular Immunology.2024; 21(6): 604.     CrossRef
  • مقارنة تأثير المستخلص المائي لثمار نبات البامية Abelmoschus Esculentus مع عقار الميتفورمين على إناث الجرذان المصابة بالسكري
    عائشة أدريس, إبراهيم عزاقة, فاطمة عبدالله
    Journal of Pure & Applied Sciences .2024; 23(1): 96.     CrossRef
  • Endoplasmic reticulum stress in pancreatic β-cell dysfunction: The potential therapeutic role of dietary flavonoids
    Kingsley C. Mbara, Marthe C.D. Fotsing, Derek T. Ndinteh, Claudine N. Mbeb, Chinekwu S. Nwagwu, Rene Khan, Kopang C. Mokhetho, Himansu Baijnath, Manimbulu Nlooto, Shoeshoe Mokhele, Carmen M. Leonard, Vuyelwa J. Tembu, Clemence Tarirai
    Current Research in Pharmacology and Drug Discovery.2024; 6: 100184.     CrossRef
  • Myricetin Restores Autophagy to Attenuate Lumbar Intervertebral Disk Degeneration Via Negative Regulation of the JAK2/STAT3 Pathway
    Tian Mao, Junchi Fan
    Biochemical Genetics.2024;[Epub]     CrossRef
  • Omnifarious fruit polyphenols: an omnipotent strategy to prevent and intervene diabetes and related complication?
    Yao Chen, Xuejiao Qie, Wei Quan, Maomao Zeng, Fang Qin, Jie Chen, Benu Adhikari, Zhiyong He
    Critical Reviews in Food Science and Nutrition.2023; 63(20): 4288.     CrossRef
  • Regulation of reactive oxygen species by phytochemicals for the management of cancer and diabetes
    Heui Min Lim, See-Hyoung Park
    Critical Reviews in Food Science and Nutrition.2023; 63(22): 5911.     CrossRef
  • Bioactive compounds from Polygonatum genus as anti-diabetic agents with future perspectives
    Yan Shi, Dun Si, Donghong Chen, Xinfeng Zhang, Zhigang Han, Qiang Yu, Jingjing Liu, Jinping Si
    Food Chemistry.2023; 408: 135183.     CrossRef
  • Venom Peptides, Polyphenols and Alkaloids: Are They the Next Antidiabetics That Will Preserve β-Cell Mass and Function in Type 2 Diabetes?
    Michele Lodato, Valérie Plaisance, Valérie Pawlowski, Maxime Kwapich, Alexandre Barras, Emeline Buissart, Stéphane Dalle, Sabine Szunerits, Jérôme Vicogne, Rabah Boukherroub, Amar Abderrahmani
    Cells.2023; 12(6): 940.     CrossRef
  • TFP5 attenuates cyclin‐dependent kinase 5‐mediated islet β‐cell damage in diabetes
    Shunyao Liu, Bo Li, Danna Ma, Yuejia Tao, Jiang Song, Li Bao, Guoqing Zhang, Hongyan Luo, Shilu Cao, Jing E, Yali Zheng
    Chemical Biology & Drug Design.2023; 102(1): 76.     CrossRef
  • Antiviral and Possible Prophylactic Significance of Myricetin for COVID-19
    Pawan K. Agrawal, Chandan Agrawal, Gerald Blunden
    Natural Product Communications.2023; 18(4): 1934578X2311662.     CrossRef
  • In Vitro and In Silico Protocols for the Assessment of Anti-Tick Compounds from Pinus roxburghii against Rhipicephalus (Boophilus) microplus Ticks
    Sana Ayub, Nosheen Malak, Raquel Cossío-Bayúgar, Nasreen Nasreen, Afshan Khan, Sadaf Niaz, Adil Khan, Abdallah D. Alanazi, Mourad Ben Said
    Animals.2023; 13(8): 1388.     CrossRef
  • Protective Effect of Myricetin Against Experimentally Induced Torsion in Rats
    M. Tatar, Z. Polat, J. Öner, H. Öner
    Biology Bulletin.2023; 50(6): 1338.     CrossRef
  • The pharmacological mechanism of Abelmoschus manihot in the treatment of chronic kidney disease
    Cuiting Wei, Chao Wang, Run Li, Yunfeng Bai, Xue Wang, Qingyun Fang, Xiangmei Chen, Ping Li
    Heliyon.2023; 9(11): e22017.     CrossRef
  • Natural Polyphenols as SERCA Activators: Role in the Endoplasmic Reticulum Stress-Related Diseases
    Jana Viskupicova, Petronela Rezbarikova
    Molecules.2022; 27(16): 5095.     CrossRef
  • Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus
    SuFang You, JingYi Zheng, YuPing Chen, HuiBin Huang
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Myricetin inhibits pseudorabies virus infection through direct inactivation and activating host antiviral defense
    Huaiyue Hu, Zhiqiang Hu, Yingying Zhang, Hongping Wan, Zhongqiong Yin, Lixia Li, Xiaoxia Liang, Xinghong Zhao, Lizi Yin, Gang Ye, Yuan-Feng Zou, Huaqiao Tang, Renyong Jia, Yaqin Chen, Hao Zhou, Xu Song
    Frontiers in Microbiology.2022;[Epub]     CrossRef
  • Effects of myricetin against cadmium-induced neurotoxicity in PC12 cells
    Azadeh Aminzadeh, Ayda Salarinejad
    Toxicology Research.2021; 10(1): 84.     CrossRef
  • Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system
    Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
    Redox Biology.2021; 45: 102029.     CrossRef
  • Chlorogenic acid and β-glucan from highland barley grain ameliorate β-cell dysfunction via inhibiting apoptosis and improving cell proliferation
    Ze-Hua Liu, Bo Li
    Food & Function.2021; 12(20): 10040.     CrossRef
  • The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice
    Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer
    Scientific Reports.2021;[Epub]     CrossRef
  • AdipoRon promotes diabetic fracture repair through endochondral ossification-based bone repair by enhancing survival and differentiation of chondrocytes
    Zhongyi Wang, Jinxin Tang, Ying Li, Yu Wang, Yanyang Guo, Qisheng Tu, Jake Chen, Chen Wang
    Experimental Cell Research.2020; 387(2): 111757.     CrossRef
  • A kinase of many talents: non-neuronal functions of CDK5 in development and disease
    Samanta Sharma, Piotr Sicinski
    Open Biology.2020; 10(1): 190287.     CrossRef
  • Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus
    Luis Sobrevia, Paola Valero, Adriana Grismaldo, Roberto Villalobos-Labra, Fabián Pardo, Mario Subiabre, Gael Armstrong, Fernando Toledo, Sofía Vega, Marcelo Cornejo, Gonzalo Fuentes, Reinaldo Marín
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2020; 1866(12): 165948.     CrossRef
  • Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications
    Yasaman Taheri, Hafiz Ansar Rasul Suleria, Natália Martins, Oksana Sytar, Ahmet Beyatli, Balakyz Yeskaliyeva, Gulnaz Seitimova, Bahare Salehi, Prabhakar Semwal, Sakshi Painuli, Anuj Kumar, Elena Azzini, Miquel Martorell, William N. Setzer, Alfred Maroyi,
    BMC Complementary Medicine and Therapies.2020;[Epub]     CrossRef
  • Current Pharmacological Trends on Myricetin
    Gudiya Gupta, Mohd Aftab Siddiqui, Mohd Muazzam Khan, Mohd Ajmal, Rabiya Ahsan, Md Azizur Rahaman, Md Afroz Ahmad, Md Arshad, Mohammad Khushtar
    Drug Research.2020;[Epub]     CrossRef
  • Silencing cyclophilin A improves insulin secretion, reduces cell apoptosis, and alleviates inflammation as well as oxidant stress in high glucose-induced pancreatic β-cells via MAPK/NF-kb signaling pathway
    Tangying Li, Huibiao Quan, Huachuan Zhang, Leweihua Lin, Qianying Ou, Kaining Chen
    Bioengineered.2020; 11(1): 1047.     CrossRef
  • Endoplasmic reticulum stress contributes to NMDA-induced pancreatic β-cell dysfunction in a CHOP-dependent manner
    Xiao-Ting Huang, Wei Liu, Yong Zhou, Mei Sun, Chen-Chen Sun, Chen-Yu Zhang, Si-Yuan Tang
    Life Sciences.2019; 232: 116612.     CrossRef
  • Dapagliflozin rescues endoplasmic reticulum stress-mediated cell death
    Ryo Shibusawa, Eijiro Yamada, Shuichi Okada, Yasuyo Nakajima, Claire C. Bastie, Akito Maeshima, Kyoichi Kaira, Masanobu Yamada
    Scientific Reports.2019;[Epub]     CrossRef
  • Myricetin prevents thapsigargin-induced CDK5-P66Shc signalosome mediated pancreatic β-cell dysfunction
    Udayakumar Karunakaran, Ji Eun Lee, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
    Free Radical Biology and Medicine.2019; 141: 59.     CrossRef
  • CDK5: Key Regulator of Apoptosis and Cell Survival
    Rabih Roufayel, Nimer Murshid
    Biomedicines.2019; 7(4): 88.     CrossRef
  • Oral DhHP-6 for the Treatment of Type 2 Diabetes Mellitus
    Kai Wang, Yu Su, Yuting Liang, Yanhui Song, Liping Wang
    International Journal of Molecular Sciences.2019; 20(6): 1517.     CrossRef
Response
Response: Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome (Diabetes Metab J 2018;42:207-14)
Sung Woo Kim, Keun-Gyu Park
Diabetes Metab J. 2018;42(4):350-352.   Published online August 21, 2018
DOI: https://doi.org/10.4093/dmj.2018.0138
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Citations

Citations to this article as recorded by  
  • Plasma Levels of Proprotein Convertase Subtilisin/Kexin Type 9 Are Inversely Associated with N-Terminal Pro B-Type Natriuretic Peptide in Older Men and Women
    Francesco Spannella, Federico Giulietti, Roberta Galeazzi, Anna Passarelli, Serena Re, Chiara Di Pentima, Massimiliano Allevi, Paolo Magni, Riccardo Sarzani
    Biomedicines.2022; 10(8): 1961.     CrossRef
  • PCSK9: Associated with cardiac diseases and their risk factors?
    Yanan Guo, Binjie Yan, Shi Tai, Shenghua Zhou, Xi-Long Zheng
    Archives of Biochemistry and Biophysics.2021; 704: 108717.     CrossRef
  • Gut Lactobacillus Level Is a Predictive Marker for Coronary Atherosclerotic Lesions Progress and Prognosis in Patients With Acute Coronary Syndrome
    Jing Gao, Jie Wang, Li-Li Zhao, Ting-Ting Yao, Yang Chen, Jing Ma, Xu Zhang, Jing-Xian Wang, Yuan Wang, Zhuang Cui, Yin Liu
    Frontiers in Cellular and Infection Microbiology.2021;[Epub]     CrossRef
  • Butein Synergizes with Statin to Upregulate Low-Density Lipoprotein Receptor ThroughHNF1α-Mediated PCSK9 Inhibition in HepG2 Cells
    Jin-Taek Hwang, Hyo Jin Kim, Hyo-Kyoung Choi, Jae-Ho Park, Sangwon Chung, Min-Yu Chung
    Journal of Medicinal Food.2020; 23(10): 1102.     CrossRef
Original Articles
Complications
Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome
Kwi-Hyun Bae, Sung Woo Kim, Yeon-Kyung Choi, Jung Beom Seo, Namkyun Kim, Chang-Yeon Kim, Won Kee Lee, Sungwoo Lee, Jung Guk Kim, In-Kyu Lee, Jang Hoon Lee, Keun-Gyu Park
Diabetes Metab J. 2018;42(3):207-214.   Published online May 2, 2018
DOI: https://doi.org/10.4093/dmj.2017.0081
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AbstractAbstract PDFPubReader   
Background

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein receptor. PCSK9 has emerged as a target for lipid-lowering therapy, but the predictive value of the serum level of PCSK9 for the severity of coronary disease is largely unknown.

Methods

From December 2009 to July 2012, 121 individuals who underwent coronary angiography (CAG) because of clinically suspected acute coronary syndrome were enrolled in this study. Serum levels of PCSK9 and metabolic parameters were measured. SYNTAX (SYNergy between percutaneous coronary intervention with [paclitaxel-eluting] TAXUS stent and cardiac surgery) and GRACE (Global Registry of Acute Coronary Events) scores were calculated.

Results

Individuals with CAG lesions (n=100) had significantly higher levels of PCSK9 than those without lesions (n=21). The study population was stratified into three groups according to serum levels of PCSK9. The odds radio for occurrence of one or more CAG lesions was significantly higher in the group with the highest level of PCSK9 (odds ratio, 7.468; P=0.011) than in the group with the lowest level of PCSK9. Serum PCSK9 was positively associated with the number of involved coronary arteries. Multivariable linear regression indicated that levels of PCSK9 were positively correlated with GRACE risk scores and SYNTAX scores.

Conclusion

Serum PCSK9 concentrations are higher in patients with coronary artery lesions, and are associated with SYNTAX and GRACE scores, suggesting that PCSK9 is a potential biomarker of the severity of coronary artery disease.

Citations

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  • Clinical Significance of PCSK9 and Soluble P-selectin in Predicting Major Adverse Cardiovascular Events After Primary Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome
    Yao Yao, Qining Qiu, Xiaoye Li, Zi Wang, Shikun Xu, Qianzhou Lv
    Cardiovascular Innovations and Applications.2024;[Epub]     CrossRef
  • Stratification in Heterozygous Familial Hypercholesterolemia: Imaging, Biomarkers, and Genetic Testing
    Pablo Corral, Carlos A. Aguilar Salinas, María Gabriela Matta, Valeria Zago, Laura Schreier
    Current Atherosclerosis Reports.2023; 25(12): 899.     CrossRef
  • Relationship of sortilin and proprotein convertase subtilisin/kexin type 9 in blood serum with the severity of carotid and coronary atherosclerosis in hypertensive patients
    Yu. Yu. Vukolova, I. V. Gubareva
    Russian Journal of Cardiology.2022; 27(2S): 4903.     CrossRef
  • PCSK9 Inhibition could be Effective for Acute Myocardial Infarction
    Baris Gencer, François Mach
    Current Medicinal Chemistry.2022; 29(6): 1016.     CrossRef
  • Peri-event plasma PCSK9 and hsCRP after an acute myocardial infarction correlate with early deterioration of left ventricular ejection fraction: a cohort study
    Lina S. Silva-Bermúdez, Andrea Vargas-Villanueva, Carlos A. Sánchez-Vallejo, Ana C. Palacio, Andrés F. Buitrago, Carlos O. Mendivil
    Lipids in Health and Disease.2022;[Epub]     CrossRef
  • Plasma Levels of Proprotein Convertase Subtilisin/Kexin Type 9 Are Inversely Associated with N-Terminal Pro B-Type Natriuretic Peptide in Older Men and Women
    Francesco Spannella, Federico Giulietti, Roberta Galeazzi, Anna Passarelli, Serena Re, Chiara Di Pentima, Massimiliano Allevi, Paolo Magni, Riccardo Sarzani
    Biomedicines.2022; 10(8): 1961.     CrossRef
  • Sex difference in circulating PCSK9 and its clinical implications
    Fang Jia, Si-Fan Fei, De-Bing Tong, Cong Xue, Jian-Jun Li
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Physiology and role of PCSK9 in vascular disease: Potential impact of localized PCSK9 in vascular wall
    Yanan Guo, Binjie Yan, Yu Gui, Zhihan Tang, Shi Tai, Shenghua Zhou, Xi‐Long Zheng
    Journal of Cellular Physiology.2021; 236(4): 2333.     CrossRef
  • PCSK9 levels do not predict severity and recurrence of cardiovascular events in patients with acute myocardial infarction
    Marianne Zeller, Gilles Lambert, Michel Farnier, Maud Maza, Brice Nativel, Luc Rochette, Catherine Vergely, Yves Cottin
    Nutrition, Metabolism and Cardiovascular Diseases.2021; 31(3): 880.     CrossRef
  • Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction
    Jing Gao, Ya-Nan Yang, Zhuang Cui, Si-Yuan Feng, Jing Ma, Chang-Ping Li, Yin Liu
    Lipids in Health and Disease.2021;[Epub]     CrossRef
  • Circulating Biomarkers for Cardiovascular Disease Risk Prediction in Patients With Cardiovascular Disease
    Yuen-Kwun Wong, Hung-Fat Tse
    Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
  • Association Between Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Concentrations and Cardiovascular Events in Cardiovascular Disease: A Systemic Review and Meta-Analysis
    Jiahui Liu, Fangfang Fan, Xingyu Luo, Wenjun Ji, Yaokun Liu, Yan Zhang, Bo Zheng
    Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
  • PCSK9 in acute coronary syndrome: analysis of associations with clinical and laboratory characteristics
    Yu. A. Drenina, K. Yu. Nikolaev
    Cardiovascular Therapy and Prevention.2020; 19(4): 2484.     CrossRef
  • Relation of Proprotein Convertase Subtilisin/Kexin Type 9 to Cardiovascular Outcomes in Patients Undergoing Percutaneous Coronary Intervention
    Ik Jun Choi, Sungmin Lim, Dongjae Lee, Won Jik Lee, Kwan Yong Lee, Mi-Jeong Kim, Doo Soo Jeon
    The American Journal of Cardiology.2020; 133: 54.     CrossRef
  • A Narrative Review and Expert Panel Recommendations on Dyslipidaemia Management After Acute Coronary Syndrome in Countries Outside Western Europe and North America
    Ashraf Reda, Wael Almahmeed, Idit Dobrecky-Mery, Po-Hsun Huang, Ursulo Juarez-Herrera, Naresh Ranjith, Tobias Sayre, Miguel Urina-Triana
    Advances in Therapy.2020; 37(5): 1754.     CrossRef
  • PCSK9 concentrations in different stages of subclinical atherosclerosis and their relationship with inflammation
    Štefan Tóth, Peter Olexa, Zdenka Hertelyová, Peter Štefanič, Ivan Kopolovets, Peter Berek, Vladimir Filip, Ryan Chakravarty, Monika Široká, Daniel Pella
    Open Chemistry.2020; 18(1): 1011.     CrossRef
  • Association of serum proprotein convertase subtilisin/kexin type 9 with early atherosclerosis in newly diagnosed type 2 diabetes mellitus
    Wen Guo, Yingyun Gong, Jie Li, Pei Qin, Jing Lu, Xiaona Li, Wenfang Zhu, Nianzhen Xu, Hongwen Zhou, Qun Zhang
    Nutrition, Metabolism and Cardiovascular Diseases.2019; 29(8): 815.     CrossRef
  • PCSK9 and atherosclerosis burden in the coronary arteries of patients undergoing coronary angiography
    Yunes Panahi, Mohsen Sadeghi Ghahrodi, Mohsen Jamshir, Mohammad Amin Safarpour, Vanessa Bianconi, Matteo Pirro, Maryam Moshkani Farahani, Amirhossein Sahebkar
    Clinical Biochemistry.2019; 74: 12.     CrossRef
  • Association of PCSK9 plasma levels with metabolic patterns and coronary atherosclerosis in patients with stable angina
    Chiara Caselli, Serena Del Turco, Rosetta Ragusa, Valentina Lorenzoni, Michiel De Graaf, Giuseppina Basta, Arthur Scholte, Raffaele De Caterina, Danilo Neglia
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • PCSK9 inhibition and inflammation: A narrative review
    Massimiliano Ruscica, Lale Tokgözoğlu, Alberto Corsini, Cesare R. Sirtori
    Atherosclerosis.2019; 288: 146.     CrossRef
  • Letter: Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome (Diabetes Metab J 2018;42:207-14)
    Jin Hwa Kim
    Diabetes & Metabolism Journal.2018; 42(4): 348.     CrossRef
  • Response: Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome (Diabetes Metab J 2018;42:207-14)
    Sung Woo Kim, Keun-Gyu Park
    Diabetes & Metabolism Journal.2018; 42(4): 350.     CrossRef
  • Serum PCSK9 levels, but not PCSK9 polymorphisms, are associated with CAD risk and lipid profiles in southern Chinese Han population
    Gaojun Cai, Lei Yu, Zhiying Huang, Li Li, Xingli Fu
    Lipids in Health and Disease.2018;[Epub]     CrossRef
Complications
Renoprotective Effect of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, in Streptozotocin-Induced Type 1 Diabetic Mice
Gwon-Soo Jung, Jae-Han Jeon, Mi Sun Choe, Sung-Woo Kim, In-Kyu Lee, Mi-Kyung Kim, Keun-Gyu Park
Diabetes Metab J. 2016;40(3):211-221.   Published online March 31, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.3.211
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AbstractAbstract PDFPubReader   
Background

Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used in the treatment of patients with type 2 diabetes and have proven protective effects on diabetic kidney disease (DKD). Whether DPP-4 inhibitors have renoprotective effects on insulin-deficient type 1 diabetes has not been comprehensively examined. The aim of this study was to determine whether gemigliptin, a new DPP-4 inhibitor, has renoprotective effects in streptozotocin (STZ)-induced type 1 diabetic mice.

Methods

Diabetes was induced by intraperitoneal administration of a single dose of STZ. Mice with diabetes were treated without or with gemigliptin (300 mg/kg) for 8 weeks. Morphological changes of the glomerular basement membrane (GBM) were observed by electron microscopy and periodic-acid Schiff staining. In addition, we measured blood glucose and urinary albumin excretion and evaluated fibrotic markers using immunohistochemical staining, quantitative reverse transcription polymerase chain reaction analysis, and Western blot analysis.

Results

Gemigliptin did not reduce the blood glucose levels of STZ-treated mice. In gemigliptin-treated mice with STZ, a significant reduction in urinary albumin excretion and GBM thickness was observed. Immunohistological examination revealed that gemigliptin attenuated renal fibrosis induced by STZ and decreased extracellular matrix protein levels, including those of type I collagen and fibronectin, and Smad3 phosphorylation. In cultured rat renal cells, gemigliptin inhibited transforming growth factor β-stimulated type I collagen and fibronectin mRNA and protein levels via down-regulation of Smad3 phosphorylation.

Conclusion

Our data demonstrate that gemigliptin has renoprotective effects on DKD, regardless of its glucose-lowering effect, suggesting that it could be used to prevent DKD, including in patients with type 1 diabetes.

Citations

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  • Diabetic fibrosis
    Izabela Tuleta, Nikolaos G. Frangogiannis
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2021; 1867(4): 166044.     CrossRef
  • Protective roles of thymoquinone and vildagliptin in manganese-induced nephrotoxicity in adult albino rats
    Heba El-Sayed Mostafa, Eman Ahmed Alaa El-Din, Dalia Abdallah El-Shafei, Nehal S. Abouhashem, Aisha Abdallah Abouhashem
    Environmental Science and Pollution Research.2021; 28(24): 31174.     CrossRef
  • Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
    Mi-Jin Kim, Na-young Kim, Yun-A Jung, Seunghyeong Lee, Gwon-Soo Jung, Jung-Guk Kim, In-Kyu Lee, Sungwoo Lee, Yeon-Kyung Choi, Keun-Gyu Park
    Diabetes & Metabolism Journal.2020; 44(1): 186.     CrossRef
  • Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome
    Jung Beom Seo, Yeon-Kyung Choi, Hye-In Woo, Yun-A Jung, Sungwoo Lee, Seunghyeong Lee, Mihyang Park, In-Kyu Lee, Gwon-Soo Jung, Keun-Gyu Park
    Diabetes & Metabolism Journal.2019; 43(6): 830.     CrossRef
  • Recent advances in the pathogenesis of microvascular complications in diabetes
    Sungmi Park, Hyeon-Ji Kang, Jae-Han Jeon, Min-Ji Kim, In-Kyu Lee
    Archives of Pharmacal Research.2019; 42(3): 252.     CrossRef
  • Diabetic nephropathy: An update on pathogenesis and drug development
    Vikram Rao A/L B Vasanth Rao, Sean Hong Tan, Mayuren Candasamy, Subrat Kumar Bhattamisra
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 754.     CrossRef
  • Mechanisms and pathways of anti‐inflammatory activity of DPP‐4 inhibitors in cardiovascular and renal protection
    Katarina Tomovic, Jelena Lazarevic, Gordana Kocic, Marina Deljanin‐Ilic, Marko Anderluh, Andrija Smelcerovic
    Medicinal Research Reviews.2019; 39(1): 404.     CrossRef
  • Effects of Dipeptidyl Peptidase-4 Inhibitors on Renal Outcomes in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
    Jae Hyun Bae, Sunhee Kim, Eun-Gee Park, Sin Gon Kim, Seokyung Hahn, Nam Hoon Kim
    Endocrinology and Metabolism.2019; 34(1): 80.     CrossRef
  • The emerging role of novel antihyperglycemic agents in the treatment of heart failure and diabetes: A focus on cardiorenal outcomes
    Kelly R. McHugh, Adam D. DeVore, Robert J. Mentz, Daniel Edmonston, Jennifer B. Green, Adrian F. Hernandez
    Clinical Cardiology.2018; 41(9): 1259.     CrossRef
  • Acute Kidney Injury and Progression of Diabetic Kidney Disease
    Samuel Mon-Wei Yu, Joseph V. Bonventre
    Advances in Chronic Kidney Disease.2018; 25(2): 166.     CrossRef
  • Recombinant human GLP-1(rhGLP-1) alleviating renal tubulointestitial injury in diabetic STZ-induced rats
    Weiqin Yin, Shiqing Xu, Zai Wang, Honglin Liu, Liang Peng, Qing Fang, Tingting Deng, Wenjian Zhang, Jinning Lou
    Biochemical and Biophysical Research Communications.2018; 495(1): 793.     CrossRef
  • Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice
    Laura E. Crotty Alexander, Christopher A. Drummond, Mark Hepokoski, Denzil Mathew, Alex Moshensky, Andrew Willeford, Soumita Das, Prabhleen Singh, Zach Yong, Jasmine H. Lee, Kevin Vega, Ashley Du, John Shin, Christian Javier, Jiang Tian, Joan Heller Brown
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2018; 314(6): R834.     CrossRef
  • Renoprotective effect of fucoidan from Acaudina molpadioides in streptozotocin/high fat diet-induced type 2 diabetic mice
    Shiwei Hu, Jinhui Wang, Jingfeng Wang, Shijie Li, Wei Jiang, Yu Liu
    Journal of Functional Foods.2017; 31: 123.     CrossRef
  • Dipeptidyl peptidase-4 inhibition and renoprotection
    Yuta Takagaki, Daisuke Koya, Keizo Kanasaki
    Current Opinion in Nephrology and Hypertension.2017; 26(1): 56.     CrossRef
  • Treatment of diabetic kidney disease: current and future targets
    Mi-Kyung Kim
    The Korean Journal of Internal Medicine.2017; 32(4): 622.     CrossRef
  • Pharmacological Treatment in Diabetes Mellitus Type 1 – Insulin and What Else?
    Ewa Otto-Buczkowska, Natalia Jainta
    International Journal of Endocrinology and Metabolism.2017;[Epub]     CrossRef
  • GLP-1 and the kidney: from physiology to pharmacology and outcomes in diabetes
    Marcel H. A. Muskiet, Lennart Tonneijck, Mark M. Smits, Michaël J.B. van Baar, Mark H. H. Kramer, Ewout J. Hoorn, Jaap A. Joles, Daniël H. van Raalte
    Nature Reviews Nephrology.2017; 13(10): 605.     CrossRef
  • Efficacy, safety and albuminuria‐reducing effect of gemigliptin in Korean type 2 diabetes patients with moderate to severe renal impairment: A 12‐week, double‐blind randomized study (the GUARD Study)
    Sun A. Yoon, Byoung G. Han, Sung G. Kim, Sang Y. Han, Young I. Jo, Kyung H. Jeong, Kook H. Oh, Hyeong C. Park, Sun H. Park, Shin W. Kang, Ki R. Na, Sun W. Kang, Nam H. Kim, Young H. Jang, Seong H. Shin, Dae R. Cha
    Diabetes, Obesity and Metabolism.2017; 19(4): 590.     CrossRef
  • Sodium butyrate has context-dependent actions on dipeptidyl peptidase-4 and other metabolic parameters
    Eun-Sol Lee, Dong-Sung Lee, Prakash Raj Pandeya, Youn-Chul Kim, Dae-Gil Kang, Ho-Sub Lee, Byung-Chul Oh, Dae Ho Lee
    The Korean Journal of Physiology & Pharmacology.2017; 21(5): 519.     CrossRef
  • Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor γ Agonist, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
    Kwi-Hyun Bae, Jung Beom Seo, Yun-A Jung, Hye-Young Seo, Sun Hee Kang, Hui-Jeon Jeon, Jae Man Lee, Sungwoo Lee, Jung-Guk Kim, In-Kyu Lee, Gwon-Soo Jung, Keun-Gyu Park
    Endocrinology and Metabolism.2017; 32(1): 115.     CrossRef
  • Gemigliptin: An Update of Its Clinical Use in the Management of Type 2 Diabetes Mellitus
    Sung-Ho Kim, Jung-Hwa Yoo, Woo Je Lee, Cheol-Young Park
    Diabetes & Metabolism Journal.2016; 40(5): 339.     CrossRef
  • Risk assessment and management of post-transplant diabetes mellitus
    Eugene Han, Myoung Soo Kim, Yu Seun Kim, Eun Seok Kang
    Metabolism.2016; 65(10): 1559.     CrossRef
Reviews
A Systematic Review of Oxidative Stress and Safety of Antioxidants in Diabetes: Focus on Islets and Their Defense
Udayakumar Karunakaran, Keun-Gyu Park
Diabetes Metab J. 2013;37(2):106-112.   Published online April 16, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.2.106
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AbstractAbstract PDFPubReader   

A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an important role in diabetic complications, especially β-cell dysfunction and failure. Under physiological conditions, reactive oxygen species serve as second messengers that facilitate signal transduction and gene expression in pancreatic β-cells. However, under pathological conditions, an imbalance in redox homeostasis leads to aberrant tissue damage and β-cell death due to a lack of antioxidant defense systems. Taking into account the vulnerability of islets to oxidative damage, induction of endogenous antioxidant enzymes or exogenous antioxidant administration has been proposed as a way to protect β-cells against diabetic insults. Here, we consider recent insights into how the redox response becomes deregulated under diabetic conditions, as well as the therapeutic benefits of antioxidants, which may provide clues for developing strategies aimed at the treatment or prevention of diabetes associated with β-cell failure.

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  • Association Between Serum Ferritin and the Duration of Type 2 Diabetes Mellitus in a Tertiary Care Hospital in Chennai
    Sankar Arumugam, Anbalagan Suyambulingam
    Cureus.2024;[Epub]     CrossRef
  • Pancreatic Parenchymal Atrophy and Pancreatic Fat Accumulation Measured by Multidetector Computed Tomography as a Stable Marker of Chronic Progressive Type 2 Diabetes Mellitus—A Cross Sectional Observational Study
    Kshipra Devadiga, Khanak K Nandolia, Mahendra Singh, Pankaj Sharma, Udit Chauhan, Ravi Kant
    Avicenna Journal of Medicine.2024; 14(01): 060.     CrossRef
  • Toward Ultrasound Molecular Imaging of Endothelial Dysfunction in Diabetes: Targets, Strategies, and Challenges
    Jiahan Liu, Chen Wang, Shuo Qiu, Wenqi Sun, Guodong Yang, Lijun Yuan
    ACS Applied Bio Materials.2024; 7(3): 1416.     CrossRef
  • Bisphenol a accelerates the glucolipotoxicity-induced dysfunction of rat insulinoma cell lines: An implication for a potential risk of environmental bisphenol a exposure for individuals susceptible to type 2 diabetes
    Chengmeng Huang, Xiaolin Chen, Zedong Ouyang, Lingxue Meng, Jian Liu, Qihua Pang, Ruifang Fan
    Toxicology in Vitro.2024; 99: 105866.     CrossRef
  • Interference of altered plasma trace elements profile with hyperhomocysteinemia and oxidative stress damage to insulin secretion dysfunction in Psammomys obesus: focus on the selenium
    Asma Bouazza, Eric Fontaine, Xavier Leverve, Elhadj-Ahmed Koceir
    Archives of Physiology and Biochemistry.2023; 129(2): 505.     CrossRef
  • Vanillic acid potentiates insulin secretion and prevents pancreatic β-cells cytotoxicity under H2O2-induced oxidative stress
    Chandan Muddahally Naganna, K. Yogendra Prasad, V. P. Mahendra, P. Ganesan, Ravi Kumar
    Molecular Biology Reports.2023; 50(2): 1311.     CrossRef
  • Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress
    Phiwayinkosi V Dludla, Sihle E Mabhida, Khanyisani Ziqubu, Bongani B Nkambule, Sithandiwe E Mazibuko-Mbeje, Sidney Hanser, Albert Kotze Basson, Carmen Pheiffer, Andre Pascal Kengne
    World Journal of Diabetes.2023; 14(3): 130.     CrossRef
  • Redox Balance in Type 2 Diabetes: Therapeutic Potential and the Challenge of Antioxidant-Based Therapy
    Lital Argaev-Frenkel, Tovit Rosenzweig
    Antioxidants.2023; 12(5): 994.     CrossRef
  • Polygenic Variants Linked to Oxidative Stress and the Antioxidant System Are Associated with Type 2 Diabetes Risk and Interact with Lifestyle Factors
    Youngjin Choi, Hyuk-Ku Kwon, Sunmin Park
    Antioxidants.2023; 12(6): 1280.     CrossRef
  • Food Anthocyanins: Malvidin and Its Glycosides as Promising Antioxidant and Anti-Inflammatory Agents with Potential Health Benefits
    Anna Merecz-Sadowska, Przemysław Sitarek, Tomasz Kowalczyk, Karolina Zajdel, Mariusz Jęcek, Paweł Nowak, Radosław Zajdel
    Nutrients.2023; 15(13): 3016.     CrossRef
  • Selenium—More than Just a Fortuitous Sulfur Substitute in Redox Biology
    Luisa B. Maia, Biplab K. Maiti, Isabel Moura, José J. G. Moura
    Molecules.2023; 29(1): 120.     CrossRef
  • Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging
    Ken-ichiro Matsumoto, Ikuo Nakanishi, Zhivko Zhelev, Rumiana Bakalova, Ichio Aoki
    Antioxidants & Redox Signaling.2022; 36(1-3): 95.     CrossRef
  • Speciation study and biological activity of copper (II) complexes with picolinic and 6-methylpicolinic acid with different components of blood serum of low molecular mass in KNO3 1.0 mol·L−1 at 25 °C
    Edgar Del Carpio, María L. Serrano, Lino Hernández, Waleska Madden, Vito Lubes, Vanessa R. Landaeta, Rafael E. Rodríguez-Lugo, Giuseppe Lubes, Anita Stern, Carlos Ciangherotti, Lissette Jiménez
    Polyhedron.2022; 211: 115562.     CrossRef
  • Pharmaceutical Formulation and Polymer Chemistry for Cell Encapsulation Applied to the Creation of a lab-on-a-chip bio-microsystem
    Armin Mooranian, Melissa Jones, Corina Mihaela Ionescu, Daniel Walker, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov, Hani Al-Salami
    Therapeutic Delivery.2022; 13(1): 51.     CrossRef
  • Racial Differences in Pain, Nutrition, and Oxidative Stress
    Larissa J. Strath, Robert E. Sorge
    Pain and Therapy.2022; 11(1): 37.     CrossRef
  • Aerobic training reduces pancreatic fat content and improves β‐cell function: A randomized controlled trial using IDEAL‐IQ magnetic resonance imaging
    Min Li, Qidong Zheng, Joshua D. Miller, Panpan Zuo, Xiaodan Yuan, Jitao Feng, Chao Liu, Shan Bao, Qingqing Lou
    Diabetes/Metabolism Research and Reviews.2022;[Epub]     CrossRef
  • Synthesis, Antioxidant, and Antidiabetic Activities of Ketone Derivatives of Succinimide
    Bushra Waheed, Syed Muhammad Mukarram Shah, Fida Hussain, Mohammad Ijaz Khan, Anwar Zeb, Muhammad Saeed Jan, Arpita Roy
    Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
  • Recent Advances and Mechanistic Insights into Antibacterial Activity, Antibiofilm Activity, and Cytotoxicity of Silver Nanoparticles
    Neetu Tripathi, Manoj Kumar Goshisht
    ACS Applied Bio Materials.2022; 5(4): 1391.     CrossRef
  • Chemical speciation, antioxidant activity and molecular docking of copper(II) complexes with pyridinedicarboxylic acids and different ligands of low molecular mass
    Edgar Del Carpio, María L. Serrano, Lino Hernández, Waleska Madden, Vito Lubes, Vanessa R. Landaeta, Rafael E. Rodríguez-Lugo, Giuseppe Lubes, Anita Stern, Carlos Ciangherotti, Lissette Jiménez
    Physics and Chemistry of Liquids.2022; 60(6): 943.     CrossRef
  • Inflammaging and Osteoarthritis
    Francesca Motta, Elisa Barone, Antonio Sica, Carlo Selmi
    Clinical Reviews in Allergy & Immunology.2022; 64(2): 222.     CrossRef
  • Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation
    Thobekile S. Leyane, Sandy W. Jere, Nicolette N. Houreld
    International Journal of Molecular Sciences.2022; 23(13): 7273.     CrossRef
  • Validation of the traditional medicinal use of a Mexican endemic orchid (Prosthechea karwinskii) through UPLC-ESI-qTOF-MS/MS characterization of its bioactive compounds
    Gabriela Soledad Barragán-Zarate, Luicita Lagunez-Rivera, Rodolfo Solano, Candy Carranza-Álvarez, Diego Manuel Hernández-Benavides, Gerard Vilarem
    Heliyon.2022; 8(7): e09867.     CrossRef
  • N-acetyl-L-cysteine ameliorates hepatocyte pyroptosis of dog type 1 diabetes mellitus via suppression of NLRP3/NF-κB pathway
    Haihua Huo, Haitong Wu, Feiyang Ma, Xinrun Li, Jianzhao Liao, Lianmei Hu, Qingyue Han, Ying Li, Jiaqiang Pan, Hui Zhang, Zhaoxin Tang, Jianying Guo
    Life Sciences.2022; 306: 120802.     CrossRef
  • Vitamin D regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin-induced diabetes
    Fatima El Zahra M. Fathi, Kadry M. Sadek, Asmaa F. Khafaga, Abdel Wahab Al senosy, Hanan A. Ghoniem, Sahar Fayez, Mohamed F. Zeweil
    Environmental Science and Pollution Research.2022; 29(60): 90219.     CrossRef
  • Hypoglycemic, Hypolipidemic and Antioxidant Potentials of Ethanolic Stem Bark Extract of Anacardium occidentale in Streptozotocin-Induced Diabetic Rats
    F. A Bamisaye, R. A Ibrahim, A.O. Sulyman, A.O. Jubril, Olawale Ajuwon
    Nigerian Journal of Physiological Sciences.2022; 37(1): 137.     CrossRef
  • Protective Effects of the Bilobalide on Retinal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats
    Qiang Su, Jing Dong, Donglei Zhang, Lu Yang, Rupak Roy
    Applied Biochemistry and Biotechnology.2022; 194(12): 6407.     CrossRef
  • Effects of Psychotropic Medication on Somatic Sterol Biosynthesis of Adult Mice
    Marta Balog, Allison C Anderson, Marija Heffer, Zeljka Korade, Karoly Mirnics
    Biomolecules.2022; 12(10): 1535.     CrossRef
  • Myricitrin and Its Solid Lipid Nanoparticle Increase Insulin Secretion and Content of Isolated Islets from the Pancreas of Male Mice
    Akram Ahangarpour, Ali Akbar Oroojan
    Brazilian Journal of Pharmaceutical Sciences.2022;[Epub]     CrossRef
  • Diabetes and plant‐derived natural products: From ethnopharmacological approaches to their potential for modern drug discovery and development
    Arun K. Jugran, Sandeep Rawat, Hari P. Devkota, Indra D. Bhatt, Ranbeer S. Rawal
    Phytotherapy Research.2021; 35(1): 223.     CrossRef
  • Exploring brain insulin resistance in adults with bipolar depression using extracellular vesicles of neuronal origin
    Rodrigo B. Mansur, Francheska Delgado-Peraza, Mehala Subramaniapillai, Yena Lee, Michelle Iacobucci, Flora Nasri, Nelson Rodrigues, Joshua D. Rosenblat, Elisa Brietzke, Victoria E. Cosgrove, Nicole E. Kramer, Trisha Suppes, Charles L. Raison, Andrea Fagio
    Journal of Psychiatric Research.2021; 133: 82.     CrossRef
  • Protective Effects of Iridoid Glycoside from Corni Fructus on Type 2 Diabetes with Nonalcoholic Fatty Liver in Mice
    Dou Niu, Xue Chen, Ting Wang, Fuxing Wang, Qiusheng Zhang, Xiaochang Xue, Jiefang Kang, Dan Qian Chen
    BioMed Research International.2021; 2021: 1.     CrossRef
  • Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes
    Jiahui Zhang, Fnu Anshul, Deepak K. Malhotra, Juan Jaume, Lance D. Dworkin, Rujun Gong
    Antioxidants.2021; 10(1): 138.     CrossRef
  • p-Terphenyls From Aspergillus sp. GZWMJZ-055: Identification, Derivation, Antioxidant and α-Glycosidase Inhibitory Activities
    Yanchao Xu, Yong Wang, Dan Wu, Wenwen He, Liping Wang, Weiming Zhu
    Frontiers in Microbiology.2021;[Epub]     CrossRef
  • Updated Role of Neuropeptide Y in Nicotine-Induced Endothelial Dysfunction and Atherosclerosis
    Yan-li Zheng, Wan-da Wang, Mei-mei Li, Shu Lin, Hui-li Lin
    Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
  • IRS-2/Akt/GSK-3β/Nrf2 Pathway Contributes to the Protective Effects of Chikusetsu Saponin IVa against Lipotoxicity
    Lei Wang, Jialin Duan, Na Jia, Meiyou Liu, Shanshan Cao, Yan Weng, Wei Zhang, Jinyi Cao, Ruili Li, Jia Cui, Jingwen Wang, Silvana Hrelia
    Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
  • In Vivo and In Vitro Assays Evaluating the Biological Activity of Taurine, Glucose and Energetic Beverages
    Marcos Mateo-Fernández, Fernando Valenzuela-Gómez, Rafael Font, Mercedes Del Río-Celestino, Tania Merinas-Amo, Ángeles Alonso-Moraga
    Molecules.2021; 26(8): 2198.     CrossRef
  • Effect of propolis on glycemic control in patients with type 2 diabetes: an updated systematic review and meta-analysis of randomized controlled trials
    Zahra Mosallanezhad, Cain Clark, Fatemeh Bahreini, Zahra Motamed, Abdolhamid Mosallanezhad, Seyedeh Fatemeh Hosseini, Aneseh Shaban-Khalaf, Zahra Sohrabi
    Nutrition & Food Science .2021; 51(7): 1124.     CrossRef
  • The Correlation between Selenium Dependent Glutathione Peroxidase Activity and Oxidant/Antioxidant Balance in Sera of Diabetic Patients with Nephropathy
    Abdulateef Altuhafi, Muhammed Altun, Mahmoud Hussein Hadwan
    Reports of Biochemistry and Molecular Biology.2021; 10(2): 164.     CrossRef
  • Effect of alpha-lipoic acid on oxidative stress parameters: A systematic review and meta-analysis
    Sanaz Rezaei Zonooz, Motahareh Hasani, Mojgan Morvaridzadeh, Ana Beatriz Pizarro, Hafez Heydari, Somaye Yosaee, Gholamreza Rezamand, Javad Heshmati
    Journal of Functional Foods.2021; 87: 104774.     CrossRef
  • The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease
    Kristian Leisegang, Shubhadeep Roychoudhury, Petr Slama, Renata Finelli
    Antioxidants.2021; 10(11): 1834.     CrossRef
  • Роль системы врождённого иммунитета и окислительного стресса в развитии сахарного диабета 1-типа. Пероксиредоксин 6 как новый антидиабетический препарат
    Е.Г. Новосёлова, О.В. Глушкова, М.О. Хренов, С.М. Лунин, Т.В. Новосёлова, С.Б. Парфенюк
    Биохимия.2021; 86(12): 1840.     CrossRef
  • Role of Innate Immunity and Oxidative Stress in the Development of Type 1 Diabetes Mellitus. Peroxiredoxin 6 as a New Anti-Diabetic Agent
    Elena G. Novoselova, Olga V. Glushkova, Maxim O. Khrenov, Sergey M. Lunin, Tatyana V. Novoselova, Svetlana B. Parfenuyk
    Biochemistry (Moscow).2021; 86(12-13): 1579.     CrossRef
  • Participation of Hsp70 and Hsp90α Heat Shock Proteins in Stress Response in the Course of Type 1 Diabetes Mellitus
    E. G. Novoselova, O. V. Glushkova, M. O. Khrenov, S. B. Parfenyuk, S. M. Lunin, T. V. Novoselova, E. E. Fesenko
    Doklady Biological Sciences.2020; 493(1): 124.     CrossRef
  • The correlation between blood oxidative stress and sialic acid content in diabetic patients with nephropathy, hypertension, and hyperlipidemia
    Sedigheh Shahvali, Armita Shahesmaeili, Mojgan Sanjari, Somayyeh Karami-Mohajeri
    Diabetology International.2020; 11(1): 19.     CrossRef
  • Green synthesis of gold nanoparticles from Fritillaria cirrhosa and its anti-diabetic activity on Streptozotocin induced rats
    Ying Guo, Nan Jiang, Li Zhang, Min Yin
    Arabian Journal of Chemistry.2020; 13(4): 5096.     CrossRef
  • The Role of Oxidative Stress in Physiopathology and Pharmacological Treatment with Pro- and Antioxidant Properties in Chronic Diseases
    Andrés García-Sánchez, Alejandra Guillermina Miranda-Díaz, Ernesto Germán Cardona-Muñoz
    Oxidative Medicine and Cellular Longevity.2020; 2020: 1.     CrossRef
  • Pharmacological and Advanced Cell Respiration Effects, Enhanced by Toxic Human-Bile Nano-Pharmaceuticals of Probucol Cell-Targeting Formulations
    Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Corina Mihaela Ionescu, Melissa Jones, Goran Stojanovic, Sanja Kojic, Armin Mooranian, Hani Al-Salami
    Pharmaceutics.2020; 12(8): 708.     CrossRef
  • Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states
    Minglei Ma, Haibin Liu, Jie Yu, Shuli He, Pingping Li, Chunxiao Ma, Huabing Zhang, Lingling Xu, Fan Ping, Wei Li, Qi Sun, Yuxiu Li
    Lipids in Health and Disease.2020;[Epub]     CrossRef
  • Protective Effects of Grape Seed Proanthocyanidins on the Kidneys of Diabetic Rats through the Nrf2 Signalling Pathway
    Yusong Ding, Haiyan Li, Yang Li, Dandan Liu, Liyuan Zhang, Tongling Wang, Tao Liu, Long Ma, Rocío De la Puerta
    Evidence-Based Complementary and Alternative Medicine.2020; 2020: 1.     CrossRef
  • The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond
    Jun Sung Moon, Udayakumar Karunakaran, Elumalai Suma, Seung Min Chung, Kyu Chang Won
    Diabetes & Metabolism Journal.2020; 44(2): 222.     CrossRef
  • Roles of Autophagy in Oxidative Stress
    Hyeong Rok Yun, Yong Hwa Jo, Jieun Kim, Yoonhwa Shin, Sung Soo Kim, Tae Gyu Choi
    International Journal of Molecular Sciences.2020; 21(9): 3289.     CrossRef
  • Antioxidant and prebiotic effects of a beverage composed by tropical fruits and yacon in alloxan-induced diabetic rats
    Ana Paula DIONISIO, Luciano Bruno de CARVALHO-SILVA, Nara Menezes VIEIRA, Nedio Jair WURLITZER, Ana Carolina da Silva PEREIRA, Maria de Fatima BORGES, Deborah dos Santos GARRUTI, Idila dos Santos ARAÚJO
    Food Science and Technology.2020; 40(1): 202.     CrossRef
  • Pro-oxidant–antioxidant balance (PAB) as a prognostic index in assessing the cardiovascular risk factors: A narrative review
    Hamideh Ghazizadeh, Maryam Saberi-Karimian, Maliheh Aghasizadeh, Reza Sahebi, Hamed Ghazavi, Hamed Khedmatgozar, Ameneh Timar, Mohadeseh Rohban, Ali Javandoost, Majid Ghayour-Mobarhan
    Obesity Medicine.2020; 19: 100272.     CrossRef
  • Rosemary Leaf Extract Inhibits Glycation, Breast Cancer Proliferation, and Diabetes Risks
    Yixiao Shen, Jing Han, Xiaoyan Zheng, Binling Ai, Yang Yang, Dao Xiao, Lili Zheng, Zhanwu Sheng
    Applied Sciences.2020; 10(7): 2249.     CrossRef
  • Trigonella stellata reduced the deleterious effects of diabetes mellitus through alleviation of oxidative stress, antioxidant- and drug-metabolizing enzymes activities
    Salah A. Sheweita, Sara A. ElHady, Hala M. Hammoda
    Journal of Ethnopharmacology.2020; 256: 112821.     CrossRef
  • A Shift Toward a Plant-Centered Diet From Young to Middle Adulthood and Subsequent Risk of Type 2 Diabetes and Weight Gain: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
    Yuni Choi, Nicole Larson, Daniel D. Gallaher, Andrew O. Odegaard, Jamal S. Rana, James M. Shikany, Lyn M. Steffen, David R. Jacobs
    Diabetes Care.2020; 43(11): 2796.     CrossRef
  • Ascorbic acid supplementation in type 2 diabetes mellitus
    Lipeng Shi, Xuqin Du, Pei Guo, Lumei Huang, Peng Qi, Qianhui Gong
    Medicine.2020; 99(45): e23125.     CrossRef
  • Analysis of the Effect of Fish Bars Made of Bilih Fish (Mystacoleuseus padangensis Blkr) Flour to Reduce Oxidative Stress in a Diabetic Rat Model
    Deni ELNOVRIZA, Hadi RIYADI, Rimbawan RIMBAWAN, Evy DAMAYANTHI, Adi WINARTO
    Journal of Nutritional Science and Vitaminology.2020; 66(Supplement): S36.     CrossRef
  • Antioxidant activity of crude ethanolic extract and fractions of Ziziphus mauritiana Lam. (Rhamnaceae) leaves from Burkina Faso
    Estelle N.H. Youl, Cyrille A.P. Ouédraogo, Moustapha Gambo, Moussa Ouédraogo, Martin Kiendrebéogo, Aristide Traoré, Innocent Pierre Guissou
    Journal of Basic and Clinical Physiology and Pharmacology.2019;[Epub]     CrossRef
  • CD36 dependent redoxosomes promotes ceramide-mediated pancreatic β-cell failure via p66Shc activation
    Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
    Free Radical Biology and Medicine.2019; 134: 505.     CrossRef
  • Comparative proteomic analysis reveals drug resistance of Staphylococcus xylosus ATCC700404 under tylosin stress
    Xin Liu, Jinpeng Wang, Mo Chen, Ruixiang Che, Wenya Ding, Fei Yu, Yonghui Zhou, Wenqiang Cui, Xing Xiaoxu, Bello-Onaghise God’spower, Yanhua Li
    BMC Veterinary Research.2019;[Epub]     CrossRef
  • The Potential of Bilih Fish (Mystacoleuseus padangensis Blkr) Flour as a Zinc Source to Control Blood Glucose and Impact on Oxidative Stress in a Diabetic Rat Model
    Deni Elnovriza, Hadi Riyadi, Rimbawan ., Evy Damayanthi, Adi Winarto
    Pakistan Journal of Nutrition.2019; 18(3): 264.     CrossRef
  • Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
    Zuo, Prather, Stetskiv, Garrison, Meade, Peace, Zhou
    International Journal of Molecular Sciences.2019; 20(18): 4472.     CrossRef
  • The variations of some salivary parameters as probable indices of the hereditary diabetes
    Menicagli Roberto, Marotta Ortensio
    International Journal of Preventive Medicine.2019; 10(1): 11.     CrossRef
  • The Interrelationship between Job Stress with the Immune System and Functional Memory of Women Working in Diagnostic Laboratories
    Mansoureh Sadeghi-Yarandi, Anahita Khodabakhshi-Koolaee, Mohammad Reza Falsafinejad, Neda Khaletbari
    The Neuroscience Journal of Shefaye Khatam.2019; 7(2): 23.     CrossRef
  • Effect of Cinnamon Administration on Fertility of Normal and Diabetic Male Rats
    Mahmoud Al-Shawabk, Abdulrahim Al Jamal
    Pakistan Journal of Nutrition.2019; 18(5): 491.     CrossRef
  • White Sesame Seed Oil Mitigates Blood Glucose Level, Reduces Oxidative Stress, and Improves Biomarkers of Hepatic and Renal Function in Participants with Type 2 Diabetes Mellitus
    Farhan Aslam, Sanaullah Iqbal, Muhammad Nasir, Aftab Ahmad Anjum
    Journal of the American College of Nutrition.2019; 38(3): 235.     CrossRef
  • Effect of combination of Gynura procumbens aqueous extract and Trigona spp. honey on fertility and libido of streptozotocin-induced hyperglycaemic male rats
    Khaidatul Akmar, MahanemMat Noor
    Asian Pacific Journal of Reproduction.2019; 8(2): 56.     CrossRef
  • Serum Antioxidant Parameters are Significantly Increased in Patients with Type 2 Diabetes Mellitus after Consumption of Chinese Propolis: A Randomized Controlled Trial Based on Fasting Serum Glucose Level
    Weina Gao, Lingling Pu, Jingyu Wei, Zhanxin Yao, Yawen Wang, Tala Shi, Liting Zhao, Changya Jiao, Changjiang Guo
    Diabetes Therapy.2018; 9(1): 101.     CrossRef
  • Baccharis trimera (Carqueja) Improves Metabolic and Redox Status in an Experimental Model of Type 1 Diabetes
    Natália Nogueira do Nascimento Kaut, Ana Carolina Silveira Rabelo, Glaucy Rodrigues Araujo, Jason Guy Taylor, Marcelo Eustáquio Silva, Maria Lúcia Pedrosa, Miriam Martins Chaves, Joamyr Victor Rossoni Junior, Daniela Caldeira Costa
    Evidence-Based Complementary and Alternative Medicine.2018; 2018: 1.     CrossRef
  • The Potential of South African Herbal Tisanes, Rooibos and Honeybush in the Management of Type 2 Diabetes Mellitus
    Olawale R. Ajuwon, Ademola O. Ayeleso, Gbenga A. Adefolaju
    Molecules.2018; 23(12): 3207.     CrossRef
  • Clinical variables and ethnicity may influenced by polymorphism of CAT −262C/T and MnSOD 47C/T antioxidant enzymes in Algerian type1 diabetes without complications
    A. Eddaikra, H. Amroun, R. Raache, A. Galleze, N. Abdallah-Elhadj, M. Azzouz, F. Meçabih, B. Mechti, M.C. Abbadi, C. Touil-Boukoffa, N. Attal
    Gene.2018; 670: 182.     CrossRef
  • Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction
    Astrid Borchert, Jacqueline Kalms, Sophia R. Roth, Marlena Rademacher, Andrea Schmidt, Hermann-Georg Holzhutter, Hartmut Kuhn, Patrick Scheerer
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2018; 1863(9): 1095.     CrossRef
  • The effects of green cardamom supplementation on blood glucose, lipids profile, oxidative stress, sirtuin-1 and irisin in type 2 diabetic patients: a study protocol for a randomized placebo-controlled clinical trial
    Mohadeseh Aghasi, Shohreh Ghazi-Zahedi, Fariba Koohdani, Fereydoun Siassi, Ensieh Nasli-Esfahani, Ali Keshavarz, Mostafa Qorbani, Hoorieh Khoshamal, Asma Salari-Moghaddam, Gity Sotoudeh
    BMC Complementary and Alternative Medicine.2018;[Epub]     CrossRef
  • Mice pancreatic islets protection from oxidative stress induced by single-walled carbon nanotubes through naringin
    A Ahangarpour, S Alboghobeish, AA Oroojan, MA Dehghani
    Human & Experimental Toxicology.2018; 37(12): 1268.     CrossRef
  • Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity
    Biplab Giri, Sananda Dey, Tanaya Das, Mrinmoy Sarkar, Jhimli Banerjee, Sandeep Kumar Dash
    Biomedicine & Pharmacotherapy.2018; 107: 306.     CrossRef
  • Cognitive dysfunction and metabolic comorbidities in mood disorders: A repurposing opportunity for glucagon-like peptide 1 receptor agonists?
    Rodrigo B. Mansur, Yena Lee, Mehala Subramaniapillai, Elisa Brietzke, Roger S. McIntyre
    Neuropharmacology.2018; 136: 335.     CrossRef
  • The protective effects of a novel synthetic β-elemene derivative on human umbilical vein endothelial cells against oxidative stress-induced injury: Involvement of antioxidation and PI3k/Akt/eNOS/NO signaling pathways
    Khalil Ali Ahmad, Hong Ze, Jichao Chen, Farhan Ullah Khan, Chen Xuezhuo, Jinyi Xu, Ding Qilong
    Biomedicine & Pharmacotherapy.2018; 106: 1734.     CrossRef
  • Curcumin alleviates liver oxidative stress in type 1 diabetic rats
    Zhenglu Xie, Binbin Wu, Guozhi Shen, Xiaqing Li, Qianying Wu
    Molecular Medicine Reports.2017;[Epub]     CrossRef
  • Treatment with a GLP−1R agonist over four weeks promotes weight loss-moderated changes in frontal-striatal brain structures in individuals with mood disorders
    Rodrigo B. Mansur, Andre Zugman, Juhie Ahmed, Danielle S. Cha, Mehala Subramaniapillai, Yena Lee, Julie Lovshin, Jung G. Lee, Jae-Hon Lee, Vladislav Drobinin, Jason Newport, Elisa Brietzke, Eva Z. Reininghaus, Kang Sim, Maj Vinberg, Natalie Rasgon, Tomas
    European Neuropsychopharmacology.2017; 27(11): 1153.     CrossRef
  • Plasma vascular endothelial growth factor B levels are increased in patients with newly diagnosed type 2 diabetes mellitus and associated with the first phase of glucose-stimulated insulin secretion function of β-cell
    J. Wu, H. Wei, H. Qu, Z. Feng, J. Long, Q. Ge, H. Deng
    Journal of Endocrinological Investigation.2017; 40(11): 1219.     CrossRef
  • Associations of Dietary Antioxidants and Risk of Type 2 Diabetes: Data from the 2007–2012 Korea National Health and Nutrition Examination Survey
    Dan Quansah, Kyungho Ha, Shinyoung Jun, Seong-Ah Kim, Sangah Shin, Gyung-Ah Wie, Hyojee Joung
    Molecules.2017; 22(10): 1664.     CrossRef
  • Curcumin attenuates oxidative stress in liver in Type 1 diabetic rats
    Zhenglu Xie, Xinqi Zeng, Xiaqing Li, Binbin Wu, Guozhi Shen, Qianying Wu, Changbiao Wu
    Open Life Sciences.2017; 12(1): 452.     CrossRef
  • Metabolic control and periodontal treatment decreases elevated oxidative stress in the early phases of type 1 diabetes onset
    Cüneyt A. Aral, Özlem Nalbantoğlu, Bilge G. Nur, Mustafa Altunsoy, Kübra Aral
    Archives of Oral Biology.2017; 82: 115.     CrossRef
  • Evaluation and Application of a Novel Quantitative Antioxidant Activity Assay Based on Cellular Metabolomics
    Jianteng Wei, Qingping Hu, Ningli Wang, Yewei Liu, Dong Pei, Duolong Di
    Chromatographia.2017; 80(4): 617.     CrossRef
  • C-X-C motif chemokine ligand 8 promotes endothelial cell homing via the Akt-signal transducer and activator of transcription pathway to accelerate healing of ischemic and hypoxic skin ulcers
    Lei Shen, Peng Zhang, Shanqiang Zhang, Liping Xie, Lijie Yao, Weiya Lang, Jie Lian, Wei Qin, Meng Zhang, Liang Ji
    Experimental and Therapeutic Medicine.2017; 13(6): 3021.     CrossRef
  • STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper
    Rachel T Scarl, C Martin Lawrence, Hannah M Gordon, Craig S Nunemaker
    Journal of Endocrinology.2017; 234(3): R123.     CrossRef
  • Current views on neuropeptide Y and diabetes-related atherosclerosis
    Wei-wei Sun, Ping Zhu, Yan-chuan Shi, Chen-liang Zhang, Xu-feng Huang, Shi-yu Liang, Zhi-yuan Song, Shu Lin
    Diabetes and Vascular Disease Research.2017; 14(4): 277.     CrossRef
  • Teucrium polium extract reverses symptoms of streptozotocin-induced diabetes in rats via rebalancing the Pdx1 and FoxO1 expressions
    Parvaneh Sadat Tabatabaie, Razieh Yazdanparast
    Biomedicine & Pharmacotherapy.2017; 93: 1033.     CrossRef
  • Morin activates the Nrf2-ARE pathway and reduces oxidative stress-induced DNA damage in pancreatic beta cells
    Pachamuthu Vanitha, Sankareswaran Senthilkumar, Sireesh Dornadula, Sundaramurthy Anandhakumar, Palanisamy Rajaguru, Kunka Mohanram Ramkumar
    European Journal of Pharmacology.2017; 801: 9.     CrossRef
  • Antioxidant status and gut microbiota change in an aging mouse model as influenced by exopolysaccharide produced by Lactobacillus plantarum YW11 isolated from Tibetan kefir
    Jian Zhang, Xiao Zhao, Yunyun Jiang, Wen Zhao, Ting Guo, Yongqiang Cao, Junwei Teng, Xiaona Hao, Juan Zhao, Zhennai Yang
    Journal of Dairy Science.2017; 100(8): 6025.     CrossRef
  • Metformin prevents glucotoxicity by alleviating oxidative and ER stress–induced CD36 expression in pancreatic beta cells
    Jun Sung Moon, Udayakumar Karunakaran, Suma Elumalai, In-Kyu Lee, Hyoung Woo Lee, Yong-Woon Kim, Kyu Chang Won
    Journal of Diabetes and its Complications.2017; 31(1): 21.     CrossRef
  • Differential dose-dependent Effects of Zinc Oxide Nanoparticles on Oxidative stress-mediated Pancreatic β-cell Death
    Swati C Asani, Rinku D Umrani, Kishore M Paknikar
    Nanomedicine.2017; 12(7): 745.     CrossRef
  • Effects of Silver Nanoparticles on Multiple Drug-Resistant Strains of Staphylococcus aureus and Pseudomonas aeruginosa from Mastitis-Infected Goats: An Alternative Approach for Antimicrobial Therapy
    Yu-Guo Yuan, Qiu-Ling Peng, Sangiliyandi Gurunathan
    International Journal of Molecular Sciences.2017; 18(3): 569.     CrossRef
  • Rac1-NADPH oxidase signaling promotes CD36 activation under glucotoxic conditions in pancreatic beta cells
    Suma Elumalai, Udayakumar Karunakaran, In Kyu Lee, Jun Sung Moon, Kyu Chang Won
    Redox Biology.2017; 11: 126.     CrossRef
  • Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin
    Samsulrizal Nurdiana, Yong Meng Goh, Hafandi Ahmad, Sulaiman Md Dom, Nur Syimal’ain Azmi, Noor Syaffinaz Noor Mohamad Zin, Mahdi Ebrahimi
    BMC Complementary and Alternative Medicine.2017;[Epub]     CrossRef
  • Murraya paniculata (L.) (Orange Jasmine): Potential Nutraceuticals with Ameliorative Effect in Alloxan‐Induced Diabetic Rats
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    Phytotherapy Research.2017; 31(11): 1747.     CrossRef
  • Exploiting biological activities of brown seaweed Ishige okamurae Yendo for potential industrial applications: a review
    K. K. Asanka Sanjeewa, Won Woo Lee, Jae-Il Kim, You-Jin Jeon
    Journal of Applied Phycology.2017; 29(6): 3109.     CrossRef
  • The thioredoxin and glutathione-dependent H2O2 consumption pathways in muscle mitochondria: Involvement in H2O2 metabolism and consequence to H2O2 efflux assays
    Daniel Munro, Sheena Banh, Emianka Sotiri, Nahid Tamanna, Jason R. Treberg
    Free Radical Biology and Medicine.2016; 96: 334.     CrossRef
  • Effect of crocin extracted from saffron on pro-oxidant–anti-oxidant balance in subjects with metabolic syndrome: A randomized, placebo-controlled clinical trial
    I. Nikbakht-Jam, M. Khademi, M. Nosrati, S. Eslami, M. Foroutan-Tanha, A. Sahebkar, S. Tavalaie, M. Ghayour-Mobarhan, G.A.A. Ferns, F. Hadizadeh, S.A.S. Tabassi, S.A. Mohajeri, M. Emamian
    European Journal of Integrative Medicine.2016; 8(3): 307.     CrossRef
  • Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic β-cell line
    Armin Mooranian, Rebecca Negrulj, Frank Arfuso, Hani Al-Salami
    Artificial Cells, Nanomedicine, and Biotechnology.2016; 44(7): 1642.     CrossRef
  • Lipid peroxidation is associated with poor control of type-2 diabetes mellitus
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    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2016; 10(2): S64.     CrossRef
  • Increased Electron Paramagnetic Resonance Signal Correlates with Mitochondrial Dysfunction and Oxidative Stress in an Alzheimer’s disease Mouse Brain
    Du Fang, Zhihua Zhang, Hang Li, Qing Yu, Justin T. Douglas, Anna Bratasz, Periannan Kuppusamy, Shirley ShiDu Yan, Hemachandra Reddy
    Journal of Alzheimer's Disease.2016; 51(2): 571.     CrossRef
  • Coffee silverskin extract improves glucose-stimulated insulin secretion and protects against streptozotocin-induced damage in pancreatic INS-1E beta cells
    Beatriz Fernandez-Gomez, Sonia Ramos, Luis Goya, María Dolores Mesa, María Dolores del Castillo, María Ángeles Martín
    Food Research International.2016; 89: 1015.     CrossRef
  • Male Subfertility Induced by Heterozygous Expression of Catalytically Inactive Glutathione Peroxidase 4 Is Rescued in Vivo by Systemic Inactivation of the Alox15 Gene
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    Journal of Biological Chemistry.2016; 291(45): 23578.     CrossRef
  • Assessment of antioxidant activity, lipid profile, general biochemical and immune system responses of Wistar rats fed with dairy dessert containing Lactobacillus acidophilus La-5
    C.S. Moura, P.C.B. Lollo, P.N. Morato, E.A. Esmerino, L.P. Margalho, V.A. Santos-Junior, P.T. Coimbra, L.P. Cappato, M.C. Silva, A.S. Garcia-Gomes, D. Granato, H.M. A. Bolini, A.S. Sant'Ana, A.G. Cruz, Jaime Amaya-Farfan
    Food Research International.2016; 90: 275.     CrossRef
  • Discovery of biomarkers for oxidative stress based on cellular metabolomics
    Ningli Wang, Jianteng Wei, Yewei Liu, Dong Pei, Qingping Hu, Yu Wang, Duolong Di
    Biomarkers.2016; 21(5): 449.     CrossRef
  • Diabetic nephropathy and endothelial dysfunction: Current and future therapies, and emerging of vascular imaging for preclinical renal-kinetic study
    Wilson KC Leung, L Gao, Parco M Siu, Christopher WK Lai
    Life Sciences.2016; 166: 121.     CrossRef
  • Brazilian Green Propolis Improves Antioxidant Function in Patients with Type 2 Diabetes Mellitus
    Liting Zhao, Lingling Pu, Jingyu Wei, Jinghua Li, Jianquan Wu, Zhonghao Xin, Weina Gao, Changjiang Guo
    International Journal of Environmental Research and Public Health.2016; 13(5): 498.     CrossRef
  • Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection
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  • Recent Breakthroughs in the Antioxidant and Anti-Inflammatory Effects of Morella and Myrica Species
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  • Oxidative Stress Type Influences the Properties of Antioxidants Containing Polyphenols in RINm5F Beta Cells
    Nathalie Auberval, Stéphanie Dal, William Bietiger, Elodie Seyfritz, Jean Peluso, Christian Muller, Minjie Zhao, Eric Marchioni, Michel Pinget, Nathalie Jeandidier, Elisa Maillard, Valérie Schini-Kerth, Séverine Sigrist
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    Udayakumar Karunakaran, Jun Sung Moon, Hyoung Woo Lee, Kyu Chang Won
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  • Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health
    James P. Kehrer, Lars-Oliver Klotz
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  • Expression of Inactive Glutathione Peroxidase 4 Leads to Embryonic Lethality, and Inactivation of theAlox15Gene Does Not Rescue Such Knock-In Mice
    Simone Hanna Brütsch, Chi Chiu Wang, Lu Li, Hannelore Stender, Nilgün Neziroglu, Constanze Richter, Hartmut Kuhn, Astrid Borchert
    Antioxidants & Redox Signaling.2015; 22(4): 281.     CrossRef
  • Islet β-cell failure in type 2 diabetes – Within the network of toxic lipids
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    Biochemical and Biophysical Research Communications.2015; 460(3): 491.     CrossRef
  • Endoplasmic reticulum stress and Nrf2 repression in circulating cells of type 2 diabetic patients without the recommended glycemic goals
    C. Mozzini, U. Garbin, C. Stranieri, A. Pasini, E. Solani, I. A. Tinelli, L. Cominacini, A.M. Fratta Pasini
    Free Radical Research.2015; 49(3): 244.     CrossRef
  • El estrés oxidativo como predictor de longevidad; estudio de casos y controles
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  • Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways
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    Food and Chemical Toxicology.2014; 66: 245.     CrossRef
  • Decreased serum CA19‐9 is associated with improvement of insulin resistance and metabolic control in patients with obesity and type 2 diabetes after Roux‐en‐Y gastric bypass
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    Journal of Diabetes Investigation.2014; 5(6): 694.     CrossRef
  • Oxidative Stress Is Associated with an Increased Antioxidant Defense in Elderly Subjects: A Multilevel Approach
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    PLoS ONE.2014; 9(9): e105881.     CrossRef
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    Pharmaceutical Biology.2014; 52(1): 74.     CrossRef
  • Diabetes Mellitus and Disturbances in Brain Connectivity: A Bidirectional Relationship?
    Rodrigo B. Mansur, Danielle S. Cha, Hanna O. Woldeyohannes, Joanna K. Soczynska, Andre Zugman, Elisa Brietzke, Roger S. McIntyre
    NeuroMolecular Medicine.2014; 16(4): 658.     CrossRef
  • Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress
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  • Vitamin C Protects against INS832/13 ^|^beta;-Cell Death and/or Dysfunction Caused by Glucolipotoxicity or 3T3-L1 Adipocyte Coculture
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    Journal of Nutritional Science and Vitaminology.2014; 60(5): 313.     CrossRef
  • Antioxidant activities of novel small-molecule polysaccharide fractions purified from Portulaca oleracea L.
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    Food Science and Biotechnology.2014; 23(6): 2045.     CrossRef
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    European Journal of Pharmacology.2014; 729: 37.     CrossRef
  • Therapeutic Roles of Heme Oxygenase-1 in Metabolic Diseases: Curcumin and Resveratrol Analogues as Possible Inducers of Heme Oxygenase-1
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    Journal of Biological Chemistry.2013; 288(43): 31010.     CrossRef
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Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
Ji Yun Jeong, Nam Ho Jeoung, Keun-Gyu Park, In-Kyu Lee
Diabetes Metab J. 2012;36(5):328-335.   Published online October 18, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.5.328
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AbstractAbstract PDFPubReader   

The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes. Although it has been reported that PDC is phosphorylated and inactivated by PDK2 and PDK4 in metabolically active tissues including liver, skeletal muscle, heart, and kidney during starvation and diabetes, the precise mechanisms by which expression of PDK2 and PDK4 are transcriptionally regulated still remains unclear. Insulin represses the expression of PDK2 and PDK4 via phosphorylation of FOXO through PI3K/Akt signaling pathway. Several nuclear hormone receptors activated due to fasting or increased fat supply, including peroxisome proliferator-activated receptors, glucocorticoid receptors, estrogen-related receptors, and thyroid hormone receptors, also participate in the up-regulation of PDK2 and PDK4; however, the endogenous ligands that bind those nuclear receptors have not been identified. It has been recently suggested that growth hormone, adiponectin, epinephrine, and rosiglitazone also control the expression of PDK4 in tissue-specific manners. In this review, we discuss several factors involved in the expressional regulation of PDK2 and PDK4, and introduce current studies aimed at providing a better understanding of the molecular mechanisms that underlie the development of metabolic diseases such as diabetes.

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    BMC Sports Science, Medicine and Rehabilitation.2024;[Epub]     CrossRef
  • 1,5-Anhydroglucitol promotes pre-B acute lymphocytic leukemia progression by driving glycolysis and reactive oxygen species formation
    Huasu Zhu, Huixian Ma, Na Dong, Min Wu, Dong Li, Linghong Liu, Qing Shi, Xiuli Ju
    BMC Cancer.2023;[Epub]     CrossRef
  • The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
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    JBMR Plus.2023;[Epub]     CrossRef
  • Targeting PDK2 rescues stress-induced impaired brain energy metabolism
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    Molecular Psychiatry.2023; 28(10): 4138.     CrossRef
  • Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion
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    Kidney International.2023; 104(4): 724.     CrossRef
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    Zhouji Ma, Youjun Ding, Xiaofeng Ding, Haining Mou, Ran Mo, Qian Tan
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    Huimin Niu, Xiayu Ren, Enxue Tan, Xing Wan, Yu Wang, Honghong Shi, Yanjuan Hou, Lihua Wang
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    Xuan Gao, Yong-Yue Gao, Hui-Ying Yan, Guang-Jie Liu, Yan Zhou, Tao Tao, Ting-Ting Yue, Cong Pang, Xiang-Xin Chen, Sen Gao, Ling-Yun Wu, Chun-Hua Hang, Wei Li
    Antioxidants & Redox Signaling.2022; 36(7-9): 505.     CrossRef
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    Tiantian Zhao, Qingsong Jin, Lili Kong, Dongdong Zhang, Yaqin Teng, Liangyan Lin, Xiaoyan Yao, Yongjun Jin, Minglong Li
    Journal of Bioenergetics and Biomembranes.2022; 54(1): 17.     CrossRef
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    Frontiers in Pharmacology.2022;[Epub]     CrossRef
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    Crystal Sang, Sasha A. Philbert, Danielle Hartland, Richard. D Unwin, Andrew W. Dowsey, Jingshu Xu, Garth J. S. Cooper
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
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    Zongling Wang, Lizhi Wang, Lina Dai, Yanan Wang, Erhong Li, Shuyuan An, Fengliang Wang, Dan Liu, Wen Pan
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  • PDK2: An Underappreciated Regulator of Liver Metabolism
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    Livers.2021; 1(2): 82.     CrossRef
  • Endocrine Influence on Cardiac Metabolism in Development and Regeneration
    Niall Graham, Guo N Huang
    Endocrinology.2021;[Epub]     CrossRef
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  • Pyruvate dehydrogenase kinase 4‐mediated metabolic reprogramming is involved in rituximab resistance in diffuse large B‐cell lymphoma by affecting the expression of MS4A1/CD20
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    Cancer Science.2021; 112(9): 3585.     CrossRef
  • Skeletal muscle energy metabolism in obesity
    Abel M. Mengeste, Arild C. Rustan, Jenny Lund
    Obesity.2021; 29(10): 1582.     CrossRef
  • Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases
    Hélène Arnould, Vincent Baudouin, Anne Baudry, Luiz W. Ribeiro, Hector Ardila-Osorio, Mathéa Pietri, Cédric Caradeuc, Cynthia Soultawi, Declan Williams, Marjorie Alvarez, Carole Crozet, Fatima Djouadi, Mireille Laforge, Gildas Bertho, Odile Kellermann, Je
    PLOS Pathogens.2021; 17(10): e1009991.     CrossRef
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    Translational Medicine Communications.2020;[Epub]     CrossRef
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    Cancer & Metabolism.2020;[Epub]     CrossRef
  • Co-expression network analysis predicts a key role of microRNAs in the adaptation of the porcine skeletal muscle to nutrient supply
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    Journal of Animal Science and Biotechnology.2020;[Epub]     CrossRef
  • Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes
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  • The pyruvate dehydrogenase kinase 2 (PDK2) is associated with conidiation, mycelial growth, and pathogenicity in Fusarium graminearum
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  • PDK2 Deficiency Prevents Ovariectomy-Induced Bone Loss in Mice by Regulating the RANKL-NFATc1 Pathway During Osteoclastogenesis
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  • PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming
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  • Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses
    Alexander L. Pendleton, Laurel R. Humphreys, Melissa A. Davis, Leticia E. Camacho, Miranda J. Anderson, Sean W. Limesand
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2019; 317(4): R513.     CrossRef
  • Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle
    Yan Li, Haiou Pan, Xuetong Zhang, Hui Wang, Shengnan Liu, Hui Zhang, Haifeng Qian, Li Wang, Hao Ying
    Journal of Agricultural and Food Chemistry.2019; 67(16): 4483.     CrossRef
  • The Effects of Sodium Dichloroacetate on Mitochondrial Dysfunction and Neuronal Death Following Hypoglycemia-Induced Injury
    A Ra Kho, Bo Young Choi, Song Hee Lee, Dae Ki Hong, Jeong Hyun Jeong, Beom Seok Kang, Dong Hyeon Kang, Kyoung-Ha Park, Jae Bong Park, Sang Won Suh
    Cells.2019; 8(5): 405.     CrossRef
  • Predictive factors for the development of diabetes in cancer patients treated with phosphatidylinositol 3-kinase inhibitors
    Gyuri Kim, Myungeun Yoo, Min Hee Hong, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Hye Ryun Kim, Yong-ho Lee, Byoung Chul Cho
    Cancer Chemotherapy and Pharmacology.2019; 84(2): 405.     CrossRef
  • Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease
    Maja Dembic, Henriette S. Andersen, Jean Bastin, Thomas K. Doktor, Thomas J. Corydon, Jörn Oliver Sass, Alexandra Lopes Costa, Fatima Djouadi, Brage S. Andresen
    Molecular Genetics and Metabolism.2019; 126(1): 64.     CrossRef
  • PDK4 Augments ER–Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity
    Themis Thoudam, Chae-Myeong Ha, Jaechan Leem, Dipanjan Chanda, Jong-Seok Park, Hyo-Jeong Kim, Jae-Han Jeon, Yeon-Kyung Choi, Suthat Liangpunsakul, Yang Hoon Huh, Tae-Hwan Kwon, Keun-Gyu Park, Robert A. Harris, Kyu-Sang Park, Hyun-Woo Rhee, In-Kyu Lee
    Diabetes.2019; 68(3): 571.     CrossRef
  • Membrane-initiated cortisol action modulates early pyruvate dehydrogenase kinase 2 (pdk2) expression in fish skeletal muscle
    Jorge E. Aedo, Rodrigo Zuloaga, Sebastián Boltaña, Alfredo Molina, Juan Antonio Valdés
    Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.2019; 233: 24.     CrossRef
  • Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis
    Wen-Qi Ma, Xue-Jiao Sun, Ying Wang, Yi Zhu, Xi-Qiong Han, Nai-Feng Liu
    Molecular and Cellular Endocrinology.2019; 479: 39.     CrossRef
  • Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation
    Azuma Kosai, Nanao Horike, Yoshiaki Takei, Akihiro Yamashita, Kaori Fujita, Takashi Kamatani, Noriyuki Tsumaki
    Biochemical and Biophysical Research Communications.2019; 516(4): 1097.     CrossRef
  • Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short-term high-fat diet
    Maria F. Newhardt, Albert Batushansky, Satoshi Matsuzaki, Zachary T. Young, Melinda West, Ngun Cer Chin, Luke I. Szweda, Michael Kinter, Kenneth M. Humphries
    Journal of Biological Chemistry.2019; 294(45): 16831.     CrossRef
  • Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation
    Ina Katrine Nitschke Pettersen, Deusdedit Tusubira, Hanan Ashrafi, Sissel Elisabeth Dyrstad, Lena Hansen, Xiao-Zheng Liu, Linn Iren Hodneland Nilsson, Nils Gunnar Løvsletten, Kjetil Berge, Hege Wergedahl, Bodil Bjørndal, Øystein Fluge, Ove Bruland, Arild
    Mitochondrion.2019; 49: 97.     CrossRef
  • Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis
    Benjamin L. Woolbright, Ganeshkumar Rajendran, Robert A. Harris, John A. Taylor
    Molecular Cancer Therapeutics.2019; 18(10): 1673.     CrossRef
  • Clinical use of plasma lactate concentration. Part 1: Physiology, pathophysiology, and measurement
    Patricia G. Rosenstein, Brett S. Tennent‐Brown, Dez Hughes
    Journal of Veterinary Emergency and Critical Care.2018; 28(2): 85.     CrossRef
  • SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart
    Danish Khan, Mohsen Sarikhani, Subhajit Dasgupta, Babukrishna Maniyadath, Anwit S. Pandit, Sneha Mishra, Faiz Ahamed, Abhinav Dubey, Nowrin Fathma, Hanudatta S. Atreya, Ullas Kolthur‐Seetharam, Nagalingam R. Sundaresan
    Journal of Cellular Physiology.2018; 233(7): 5478.     CrossRef
  • Metabolic Changes Associated With Muscle Expression of SOD1G93A
    Gabriella Dobrowolny, Elisa Lepore, Martina Martini, Laura Barberi, Abigail Nunn, Bianca Maria Scicchitano, Antonio Musarò
    Frontiers in Physiology.2018;[Epub]     CrossRef
  • Effect of sex on glucose handling by adipocytes isolated from rat subcutaneous, mesenteric and perigonadal adipose tissue
    Floriana Rotondo, Ana Cecilia Ho-Palma, Xavier Remesar, José Antonio Fernández-López, María del Mar Romero, Marià Alemany
    PeerJ.2018; 6: e5440.     CrossRef
  • Heat stress decreases metabolic flexibility in skeletal muscle of growing pigs
    Lidan Zhao, Ryan P. McMillan, Guohao Xie, Samantha G. L. W. Giridhar, Lance H. Baumgard, Samer El-Kadi, Joshua Selsby, Jason Ross, Nicholas Gabler, Matthew W. Hulver, Robert P. Rhoads
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2018; 315(6): R1096.     CrossRef
  • Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism
    Rong Ke, Qicao Xu, Cong Li, Lingyu Luo, Deqiang Huang
    Cell Biology International.2018; 42(4): 384.     CrossRef
  • Advanced glycation end products accelerate calcification in VSMCs through HIF-1α/PDK4 activation and suppress glucose metabolism
    Yi Zhu, Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Nai-Feng Liu
    Scientific Reports.2018;[Epub]     CrossRef
  • Nε-carboxymethyl-lysine promotes calcium deposition in VSMCs via intracellular oxidative stress-induced PDK4 activation and alters glucose metabolism
    Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Yi Zhu, Nai-Feng Liu
    Oncotarget.2017; 8(68): 112841.     CrossRef
  • Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury
    Chang Joo Oh, Chae-Myeong Ha, Young-Keun Choi, Sungmi Park, Mi Sun Choe, Nam Ho Jeoung, Yang Hoon Huh, Hyo-Jeong Kim, Hee-Seok Kweon, Ji-min Lee, Sun Joo Lee, Jae-Han Jeon, Robert A. Harris, Keun-Gyu Park, In-Kyu Lee
    Kidney International.2017; 91(4): 880.     CrossRef
  • PPARβ/δ in human cancer
    Rolf Müller
    Biochimie.2017; 136: 90.     CrossRef
  • The physiological and molecular response of Aurelia sp.1 under hypoxia
    Guoshan Wang, Yu Zhen, Zhigang Yu, Yan Shi, Qing Zhao, Jianyan Wang, Tiezhu Mi
    Scientific Reports.2017;[Epub]     CrossRef
  • A Drosophila model of GDAP1 function reveals the involvement of insulin signalling in the mitochondria-dependent neuromuscular degeneration
    Víctor López del Amo, Martina Palomino-Schätzlein, Marta Seco-Cervera, José Luis García-Giménez, Federico Vicente Pallardó, Antonio Pineda-Lucena, Máximo Ibo Galindo
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2017; 1863(3): 801.     CrossRef
  • Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity
    Mikael Niku, Anne-Maria Pajari, Laura Sarantaus, Essi Päivärinta, Markus Storvik, Anu Heiman-Lindh, Santeri Suokas, Minna Nyström, Marja Mutanen
    The Journal of Nutritional Biochemistry.2017; 39: 126.     CrossRef
  • Small heterodimer partner (SHP) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice
    Jung Hun Ohn, Ji Yeon Hwang, Min Kyong Moon, Hwa Young Ahn, Hwan Hee Kim, Young Do Koo, Kwang-Il Kim, Hyuk Jae Chang, Hye Seung Lee, Hak Chul Jang, Young Joo Park, Catherine Mounier
    PLOS ONE.2017; 12(10): e0186021.     CrossRef
  • Involvement of oxidative modification of proteins related to ATP synthesis in the left ventricles of hamsters with cardiomyopathy
    Sahoko Ichihara, Yuka Suzuki, Jie Chang, Kentaro Kuzuya, Chisa Inoue, Yuki Kitamura, Shinji Oikawa
    Scientific Reports.2017;[Epub]     CrossRef
  • Early induction of pyruvate dehydrogenase kinase 4 by retinoic acids in adipocytes
    Emilie Distel, Thomas Cadoudal, Martine Collinet, Edwards A. Park, Chantal Benelli, Sylvie Bortoli
    Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
  • Oncogenic role of PDK4 in human colon cancer cells
    D Leclerc, D N T Pham, N Lévesque, M Truongcao, W D Foulkes, C Sapienza, R Rozen
    British Journal of Cancer.2017; 116(7): 930.     CrossRef
  • Fasting and Glucagon Stimulate Gene Expression of Pyruvate Dehydrogenase Kinase 4 in Chickens
    Kazuhisa Honda, Shoko Takagi, Kiyotaka Kurachi, Haruka Sugimoto, Takaoki Saneyasu, Hiroshi Kamisoyama
    The Journal of Poultry Science.2017; 54(4): 292.     CrossRef
  • Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
    Peter W Stacpoole
    JNCI: Journal of the National Cancer Institute.2017;[Epub]     CrossRef
  • Reference Gene Selection and Prednisolone Target Gene Expression in Adipose Tissues of Friesian Cattle
    Sara Divari, Enrica Berio, Bartolomeo Biolatti, Francesca Tiziana Cannizzo
    Journal of Agricultural and Food Chemistry.2017; 65(50): 11140.     CrossRef
  • Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease
    Luana Naia, Teresa Cunha-Oliveira, Joana Rodrigues, Tatiana R. Rosenstock, Ana Oliveira, Márcio Ribeiro, Catarina Carmo, Sofia I. Oliveira-Sousa, Ana I. Duarte, Michael R. Hayden, A. Cristina Rego
    The Journal of Neuroscience.2017; 37(10): 2776.     CrossRef
  • Black Adzuki Bean (Vigna angularis) Extract Protects Pancreatic β Cells and Improves Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet
    Mina Kim, Dae Keun Kim, Youn-Soo Cha
    Journal of Medicinal Food.2016; 19(5): 442.     CrossRef
  • Inflammation increases pyruvate dehydrogenase kinase 4 (PDK4) expression via the Jun N-Terminal Kinase (JNK) pathway in C2C12 cells
    Hana Park, Nam Ho Jeoung
    Biochemical and Biophysical Research Communications.2016; 469(4): 1049.     CrossRef
  • Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
    Jaechan Leem, In-Kyu Lee
    Endocrinology and Metabolism.2016; 31(1): 52.     CrossRef
  • Molecular Mechanisms of Obesity-Induced Osteoporosis and Muscle Atrophy
    Bipradas Roy, Mary E. Curtis, Letimicia S. Fears, Samuel N. Nahashon, Hugh M. Fentress
    Frontiers in Physiology.2016;[Epub]     CrossRef
  • MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice
    Xiaolin Lin, Yujuan Qin, Junshuang Jia, Taoyan Lin, Xia Lin, Li Chen, Hui Zeng, Yanjiang Han, Lihong Wu, Shun Huang, Meng Wang, Shenhao Huang, Raoying Xie, Liqi Liang, Yu Liu, Ruiyu Liu, Tingting Zhang, Jing Li, Shengchun Wang, Penghui Sun, Wenhua Huang,
    PLOS Genetics.2016; 12(10): e1006308.     CrossRef
  • Transforming Growth Factor β Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer
    Yang Zhang, Yi Zhang, Liying Geng, Haowei Yi, Wei Huo, Geoffrey Talmon, Yeong C. Kim, San Ming Wang, Jing Wang
    Journal of Biological Chemistry.2016; 291(33): 17405.     CrossRef
  • Metabolic Response to Heat Stress in Late-Pregnant and Early Lactation Dairy Cows: Implications to Liver-Muscle Crosstalk
    Franziska Koch, Ole Lamp, Mehdi Eslamizad, Joachim Weitzel, Björn Kuhla, Andrew C. Gill
    PLOS ONE.2016; 11(8): e0160912.     CrossRef
  • Short chain acyl-CoA dehydrogenase deficiency and short-term high-fat diet perturb mitochondrial energy metabolism and transcriptional control of lipid-handling in liver
    Sujoy Ghosh, Claudia Kruger, Shawna Wicks, Jacob Simon, K. Ganesh Kumar, William D. Johnson, Randall L. Mynatt, Robert C. Noland, Brenda K. Richards
    Nutrition & Metabolism.2016;[Epub]     CrossRef
  • Metabolic reprogramming by the pyruvate dehydrogenase kinase–lactic acid axis: Linking metabolism and diverse neuropathophysiologies
    Mithilesh Kumar Jha, In-Kyu Lee, Kyoungho Suk
    Neuroscience & Biobehavioral Reviews.2016; 68: 1.     CrossRef
  • 1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells
    Zachary C. Ryan, Theodore A. Craig, Clifford D. Folmes, Xuewei Wang, Ian R. Lanza, Niccole S. Schaible, Jeffrey L. Salisbury, K. Sreekumaran Nair, Andre Terzic, Gary C. Sieck, Rajiv Kumar
    Journal of Biological Chemistry.2016; 291(3): 1514.     CrossRef
  • Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells
    Sina Oppermann, Avery J. Lam, Stephanie Tung, Yonghong Shi, Lindsay McCaw, Guizhei Wang, Jarkko Ylanko, Brian Leber, David Andrews, David E. Spaner
    Oncotarget.2016; 7(45): 72608.     CrossRef
  • Energy metabolic disorder is a major risk factor in severe influenza virus infection: Proposals for new therapeutic options based on animal model experiments
    Hiroshi Kido, Irene L. Indalao, Hyejin Kim, Takashi Kimoto, Satoko Sakai, Etsuhisa Takahashi
    Respiratory Investigation.2016; 54(5): 312.     CrossRef
  • Fusarium graminearum pyruvate dehydrogenase kinase 1 (FgPDK1) Is Critical for Conidiation, Mycelium Growth, and Pathogenicity
    Tao Gao, Jian Chen, Zhiqi Shi, Yin-Won Lee
    PLOS ONE.2016; 11(6): e0158077.     CrossRef
  • Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase
    Michael J. Bround, Rich Wambolt, Haoning Cen, Parisa Asghari, Razvan F. Albu, Jun Han, Donald McAfee, Marc Pourrier, Nichollas E. Scott, Lubos Bohunek, Jerzy E. Kulpa, S. R. Wayne Chen, David Fedida, Roger W. Brownsey, Christoph H. Borchers, Leonard J. Fo
    Journal of Biological Chemistry.2016; 291(45): 23490.     CrossRef
  • Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
    Nam Ho Jeoung
    Diabetes & Metabolism Journal.2015; 39(3): 188.     CrossRef
  • Novel molecular mechanisms involved in hormonal regulation of lactate production in Sertoli cells
    Mariana Regueira, Silvana Lucía Artagaveytia, María Noel Galardo, Eliana Herminia Pellizzari, Selva Beatriz Cigorraga, Silvina Beatriz Meroni, María Fernanda Riera
    REPRODUCTION.2015; 150(4): 311.     CrossRef
  • Influence of dietary fatty acids on differentiation of human stromal vascular fraction preadipocytes
    Anna Polus, Beata Kiec-Wilk, Urszula Razny, Anna Gielicz, Gerd Schmitz, Aldona Dembinska-Kiec
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2015; 1851(9): 1146.     CrossRef
  • A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis
    Lavinia Palamiuc, Anna Schlagowski, Shyuan T Ngo, Aurelia Vernay, Sylvie Dirrig‐Grosch, Alexandre Henriques, Anne‐Laurence Boutillier, Joffrey Zoll, Andoni Echaniz‐Laguna, Jean‐Philippe Loeffler, Frédérique René
    EMBO Molecular Medicine.2015; 7(5): 526.     CrossRef
  • A genetic perspective on rapid evolution in cane toads (Rhinella marina)
    Lee A. Rollins, Mark F. Richardson, Richard Shine
    Molecular Ecology.2015; 24(9): 2264.     CrossRef
  • Transcriptome profiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism
    Qin Hao, Rachita Yadav, Astrid L. Basse, Sidsel Petersen, Si B. Sonne, Simon Rasmussen, Qianhua Zhu, Zhike Lu, Jun Wang, Karine Audouze, Ramneek Gupta, Lise Madsen, Karsten Kristiansen, Jacob B. Hansen
    American Journal of Physiology-Endocrinology and Metabolism.2015; 308(5): E380.     CrossRef
  • Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation
    Sun Joo Lee, Ji Yun Jeong, Chang Joo Oh, Sungmi Park, Joon-Young Kim, Han-Jong Kim, Nam Doo Kim, Young-Keun Choi, Ji-Yeon Do, Younghoon Go, Chae-Myeong Ha, Je-Yong Choi, Seung Huh, Nam Ho Jeoung, Ki-Up Lee, Hueng-Sik Choi, Yu Wang, Keun-Gyu Park, Robert A
    Scientific Reports.2015;[Epub]     CrossRef
  • Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction
    Laura D. Brown, Paul J. Rozance, Jennifer L. Bruce, Jacob E. Friedman, William W. Hay, Stephanie R. Wesolowski
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2015; 309(8): R920.     CrossRef
  • The long‐acting β2‐adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor‐mediated transcription in human airway epithelial cells in a gene‐ and agonist‐dependent manner
    T Joshi, M Johnson, R Newton, M A Giembycz
    British Journal of Pharmacology.2015; 172(10): 2634.     CrossRef
  • The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism
    Jianrong Lu, Ming Tan, Qingsong Cai
    Cancer Letters.2015; 356(2): 156.     CrossRef
  • The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
    In-Kyu Lee
    Diabetes & Metabolism Journal.2014; 38(3): 181.     CrossRef
  • Rapid in Vitro Metabolism of the Flame Retardant Triphenyl Phosphate and Effects on Cytotoxicity and mRNA Expression in Chicken Embryonic Hepatocytes
    Guanyong Su, Doug Crump, Robert J. Letcher, Sean W. Kennedy
    Environmental Science & Technology.2014; 48(22): 13511.     CrossRef
  • Low force contractions induce fatigue consistent with muscle mRNA expression in people with spinal cord injury
    Michael A. Petrie, Manish Suneja, Elizabeth Faidley, Richard K. Shields
    Physiological Reports.2014; 2(2): e00248.     CrossRef
  • Diisopropylamine Dichloroacetate, a Novel Pyruvate Dehydrogenase Kinase 4 Inhibitor, as a Potential Therapeutic Agent for Metabolic Disorders and Multiorgan Failure in Severe Influenza
    Kazuhiko Yamane, Irene L. Indalao, Junji Chida, Yoshikazu Yamamoto, Masaaki Hanawa, Hiroshi Kido, Amy Lynn Adamson
    PLoS ONE.2014; 9(5): e98032.     CrossRef
  • Fatty Acid Transport Protein 1 (FATP1) Localizes in Mitochondria in Mouse Skeletal Muscle and Regulates Lipid and Ketone Body Disposal
    Maria Guitart, Óscar Osorio-Conles, Thais Pentinat, Judith Cebrià, Judit García-Villoria, David Sala, David Sebastián, Antonio Zorzano, Antonia Ribes, Josep C. Jiménez-Chillarón, Celia García-Martínez, Anna M. Gómez-Foix, Cedric Moro
    PLoS ONE.2014; 9(5): e98109.     CrossRef
  • CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism
    Blake C. Ellis, Lloyd D. Graham, Peter L. Molloy
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2014; 1843(2): 372.     CrossRef
  • DLK1/PREF1 regulates nutrient metabolism and protects from steatosis
    Marika Charalambous, Simao Teixeira Da Rocha, Elizabeth Jane Radford, Gema Medina-Gomez, Scott Curran, Scarlett B. Pinnock, Sacri R. Ferrón, Antonio Vidal-Puig, Anne C. Ferguson-Smith
    Proceedings of the National Academy of Sciences.2014; 111(45): 16088.     CrossRef
  • The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
    Shuai Zhang, Matthew W Hulver, Ryan P McMillan, Mark A Cline, Elizabeth R Gilbert
    Nutrition & Metabolism.2014;[Epub]     CrossRef
  • Time‐dependent effects of the flame retardant tris(1,3‐dichloro‐2‐propyl) phosphate (TDCPP) on mRNA expression, in vitro and in ovo, reveal optimal sampling times for rapidly metabolized compounds
    Amani Farhat, Doug Crump, Emily Porter, Suzanne Chiu, Robert J. Letcher, Guanyong Su, Sean W. Kennedy
    Environmental Toxicology and Chemistry.2014; 33(12): 2842.     CrossRef
  • Chickens from lines selected for high and low body weight show differences in fatty acid oxidation efficiency and metabolic flexibility in skeletal muscle and white adipose tissue
    S Zhang, R P McMillan, M W Hulver, P B Siegel, L H Sumners, W Zhang, M A Cline, E R Gilbert
    International Journal of Obesity.2014; 38(10): 1374.     CrossRef
  • Pathway-selective Insulin Resistance and Metabolic Disease: The Importance of Nutrient Flux
    Yolanda F. Otero, John M. Stafford, Owen P. McGuinness
    Journal of Biological Chemistry.2014; 289(30): 20462.     CrossRef
  • Remodeling of Oxidative Energy Metabolism by Galactose Improves Glucose Handling and Metabolic Switching in Human Skeletal Muscle Cells
    Eili Tranheim Kase, Nataša Nikolić, Siril Skaret Bakke, Kaja Kamilla Bogen, Vigdis Aas, G. Hege Thoresen, Arild Christian Rustan, Darcy Johannsen
    PLoS ONE.2013; 8(4): e59972.     CrossRef
  • Association of Estrogen Receptor α GenesPvuII andXbaI Polymorphisms with Type 2 Diabetes Mellitus in the Inpatient Population of a Hospital in Southern Iran
    Farzaneh Mohammadi, Mohammad Pourahmadi, Mohadeseh Mosalanejad, Houshang Jamali, Mohamed Amin Ghobadifar, Saeideh Erfanian
    Diabetes & Metabolism Journal.2013; 37(4): 270.     CrossRef
  • The orphan nuclear receptors in cancer and diabetes
    Harmit S. Ranhotra
    Journal of Receptors and Signal Transduction.2013; 33(4): 207.     CrossRef
  • Genes with Aberrant Expression in Murine Preneoplastic Intestine Show Epigenetic and Expression Changes in Normal Mucosa of Colon Cancer Patients
    Daniel Leclerc, Nancy Lévesque, Yuanhang Cao, Liyuan Deng, Qing Wu, Jasmine Powell, Carmen Sapienza, Rima Rozen
    Cancer Prevention Research.2013; 6(11): 1171.     CrossRef
Original Article
Relationship between Chemerin Levels and Cardiometabolic Parameters and Degree of Coronary Stenosis in Korean Patients with Coronary Artery Disease
Yu-Jin Hah, Nam-Keong Kim, Mi-Kyung Kim, Hye-Soon Kim, Seung-Ho Hur, Hyuck-Jun Yoon, Yoon-Nyun Kim, Keun-Gyu Park
Diabetes Metab J. 2011;35(3):248-254.   Published online June 30, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.3.248
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AbstractAbstract PDFPubReader   
Background

Chemerin is a novel adipokine that is associated with inflammation and adipogenesis. However, it remains unclear whether chemerin is involved in patients with cardiovascular disease. We investigated whether the serum chemerin levels of Korean patients with coronary artery disease correlated with specific cardiometabolic parameters.

Methods

In total, 131 patients, all of whom had coronary artery stenosis exceeding 50%, participated in this study. Their serum chemerin levels and cardiometabolic parameters were measured. The serum chemerin levels of two groups of patients were compared; those with one stenotic vessel (n=68) and those with multiple stenotic vessels, including left main coronary artery disease (n=63).

Results

Serum chemerin levels correlated positively with the degree of coronary artery stenosis and fasting glucose, triglyceride, total cholesterol, low density lipoprotein cholesterol, and high sensitive C-reactive protein levels. The group with multiple stenotic vessels, including left main disease, had higher chemerin levels than the group with one stenotic vessel (t=-2.129, P=0.035). Multiple binary logistic regression showed chemerin was not an independent risk factor of multiple vessel disease (odds ratio, 1.018; confidence interval, 0.997 to 1.040; P=0.091).

Conclusion

Serum chemerin levels have a significant correlation with several cardiometabolic risk factors and the degree of coronary artery stenosis in Korean patients with coronary artery disease. However, multiple binary logistic regression showed chemerin was not an independent risk factor of multiple vessel disease. Additional investigations are necessary to fully elucidate the role of chemerin in cardiovascular disease.

Citations

Citations to this article as recorded by  
  • Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia
    Lunbo Tan, Zijun Ouyang, Zhilong Chen, Fen Sun, Haichun Guo, Feng Wang, Monique Mulder, Yuan Sun, Xifeng Lu, Jian V. Zhang, A. H. Jan Danser, Koen Verdonk, Xiujun Fan, Qing Yang
    Lipids in Health and Disease.2023;[Epub]     CrossRef
  • Chemerin Levels in Acute Coronary Syndrome: Systematic Review and Meta-Analysis
    Abdulrahman Ismaiel, Mohammad Zeeshan Ashfaq, Daniel-Corneliu Leucuta, Mohamed Ismaiel, Dilara Ensar Ismaiel, Stefan-Lucian Popa, Dan L Dumitrascu
    Laboratory Medicine.2022; 53(6): 552.     CrossRef
  • Prognostic value of plasma adipokine chemerin in patients with coronary artery disease
    Bo Wang, Wenxin Kou, Shuya Ji, Rongrong Shen, Hongwei Ji, Jianhui Zhuang, Yifan Zhao, Bo Li, Wenhui Peng, Xuejing Yu, Hailing Li, Yawei Xu
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Role of Chemerin in Cardiovascular Diseases
    Mirjana T. Macvanin, Manfredi Rizzo, Jelena Radovanovic, Alper Sonmez, Francesco Paneni, Esma R. Isenovic
    Biomedicines.2022; 10(11): 2970.     CrossRef
  • Chemerin in inflammatory diseases
    Xin Su, Ye Cheng, Guoming Zhang, Bin Wang
    Clinica Chimica Acta.2021; 517: 41.     CrossRef
  • Chemerin activity in selected pathological states of human body – A systematic review
    Magdalena Acewicz, Irena Kasacka
    Advances in Medical Sciences.2021; 66(2): 270.     CrossRef
  • Chemerin in atherosclerosis
    Jia-Xiang Sun, Chi Zhang, Zhe-Bin Cheng, Mu-Yao Tang, Yi-Zhang Liu, Jie-Feng Jiang, Xuan Xiao, Liang Huang
    Clinica Chimica Acta.2021; 520: 8.     CrossRef
  • Serum Chemerin Concentration Is Associated with Proinflammatory Status in Chronic Coronary Syndrome
    Anna Szpakowicz, Malgorzata Szpakowicz, Magda Lapinska, Marlena Paniczko, Slawomir Lawicki, Andrzej Raczkowski, Marcin Kondraciuk, Emilia Sawicka, Malgorzata Chlabicz, Marcin Kozuch, Maciej Poludniewski, Slawomir Dobrzycki, Irina Kowalska, Karol Kaminski
    Biomolecules.2021; 11(8): 1149.     CrossRef
  • Novo Efeito Cardioprotetor da L-Carnitina em Camundongos Obesos Diabéticos: Regulação da Expressão de Quemerina e CMKLRI no Coração e Tecidos Adiposos
    Rezvan Amiri, Mohammad Reza Tabandeh, Seyed Ahmad Hosseini
    Arquivos Brasileiros de Cardiologia.2021; 117(4): 715.     CrossRef
  • The role of adipokines in the regulation of cardiovascular function
    A. V. Karpushev, V. B. Mikhailova
    "Arterial’naya Gipertenziya" ("Arterial Hypertension").2020; 25(5): 448.     CrossRef
  • The associations among RARRES2 rs17173608 gene polymorphism, serum chemerin, and non-traditional lipid profile in patients with metabolic syndrome
    Marwa A. Dahpy, Marwa K. Khairallah, Nashwa Mostafa A. Azoz, Ghada M. Ezzat
    Egyptian Journal of Medical Human Genetics.2020;[Epub]     CrossRef
  • Serum chemerin as a predictor of left ventricle hypertrophy in patients with coronary artery disease
    NohaHasssanin Hanboly, Yasser Sharaf, Mervat Al-Anany, Essam Saeed
    Nigerian Journal of Cardiology.2019; 16(1): 25.     CrossRef
  • Association of Circulating Chemerin With Subclinical Parameters of Atherosclerosis
    Stephanie Zylla, Marcus Dörr, Henry Völzke, Ulf Schminke, Stephan B. Felix, Matthias Nauck, Nele Friedrich
    Arteriosclerosis, Thrombosis, and Vascular Biology.2018; 38(7): 1656.     CrossRef
  • Six weeks of combined aerobic and resistance exercise using outdoor exercise machines improves fitness, insulin resistance, and chemerin in the Korean elderly: A pilot randomized controlled trial
    Dong-Il Kim, Dong Hoon Lee, Sunghyun Hong, Sung-won Jo, Young-shin Won, Justin Y. Jeon
    Archives of Gerontology and Geriatrics.2018; 75: 59.     CrossRef
  • Relationship between serum chemerin levels and insulin resistance index and cardio–respiratory function in non–active obese and lean men
    Mehdi Abbaszadegan, Farhad Kouhi achachluie
    Advances in Obesity, Weight Management & Control.2018;[Epub]     CrossRef
  • Serum levels of chemerin, apelin, vaspin, and omentin-1 in obese type 2 diabetic Egyptian patients with coronary artery stenosis
    Tarek M.K. Motawi, Soliman G. Mahdy, Maha M. El-Sawalhi, Eman N. Ali, Rania Farag A. El-Telbany
    Canadian Journal of Physiology and Pharmacology.2018; 96(1): 38.     CrossRef
  • Plasma CXCL1 levels and TRAF3IP2 variants in patients with myocardial infarction
    Safoora Pordel, Mahdi Sajedi Khanian, Mohammad Hossein Karimi, Hossein Nikoo, Mehrnoosh Doroudchi
    Journal of Clinical Laboratory Analysis.2018;[Epub]     CrossRef
  • Serum Chemerin Levels are Associated with Visceral Adiposity, Independent of Waist Circumference, in Newly Diagnosed Type 2 Diabetic Subjects
    Dae Young Cheon, Jun Goo Kang, Seong Jin Lee, Sung Hee Ihm, Eun Jig Lee, Moon Gi Choi, Hyung Joon Yoo, Chul Sik Kim
    Yonsei Medical Journal.2017; 58(2): 319.     CrossRef
  • The comparison of chemerin, adiponectin and lipid profile indices in obese and non-obese adolescents
    Zahra Maghsoudi, Roya Kelishadi, Mohammad Javad Hosseinzadeh-Attar
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2016; 10(2): S43.     CrossRef
  • Chemerin processing in the myocardium: A mechanism in search of a function
    Michael V.G. Latronico, Gianluigi Condorelli
    Journal of Molecular and Cellular Cardiology.2016; 100: 21.     CrossRef
  • Chemerin as an independent predictor of cardiovascular event risk
    Sinan İnci, Gökhan Aksan, Pınar Doğan
    Therapeutic Advances in Endocrinology and Metabolism.2016; 7(2): 57.     CrossRef
  • Chemerin level in pregnancies complicated by preeclampsia and its relation with disease severity and neonatal outcomes
    Orkun Cetin, Zehra Kurdoglu, Mertihan Kurdoglu, H. Guler Sahin
    Journal of Obstetrics and Gynaecology.2016; : 1.     CrossRef
  • Chemerin in renal dysfunction and cardiovascular disease
    Mario Bonomini, Assunta Pandolfi
    Vascular Pharmacology.2016; 77: 28.     CrossRef
  • High plasma chemerin is associated with renal dysfunction and predictive for cardiovascular events — Insights from phenotype and genotype characterization
    Andreas Leiherer, Axel Muendlein, Elena Kinz, Alexander Vonbank, Philipp Rein, Peter Fraunberger, Cornelia Malin, Christoph H. Saely, Heinz Drexel
    Vascular Pharmacology.2016; 77: 60.     CrossRef
  • Chemerin plays a protective role by regulating human umbilical vein endothelial cell-induced nitric oxide signaling in preeclampsia
    Liqiong Wang, Tianli Yang, Yiling Ding, Yan Zhong, Ling Yu, Mei Peng
    Endocrine.2015; 48(1): 299.     CrossRef
  • Evaluation of the salivary levels of visfatin, chemerin, and progranulin in periodontal inflammation
    Erkan Özcan, N. Işıl Saygun, Muhittin A. Serdar, Nezahat Kurt
    Clinical Oral Investigations.2015; 19(4): 921.     CrossRef
  • Elevated serum chemerin in Chinese women with hyperandrogenic PCOS
    LiQiong Wang, Yan Zhong, YiLing Ding, XiaoBo Shi, Jian Huang, FuFan Zhu
    Gynecological Endocrinology.2014; 30(10): 746.     CrossRef
  • Chemerin reduces vascular nitric oxide/cGMP signalling in rat aorta: a link to vascular dysfunction in obesity?
    Karla Bianca Neves, Núbia S. Lobato, Rhéure Alves Moreira Lopes, Fernando P. Filgueira, Camila Ziliotto Zanotto, Ana Maria Oliveira, Rita C. Tostes
    Clinical Science.2014; 127(2): 111.     CrossRef
  • Chemerin levels as predictor of acute coronary events: A case–control study nested within the veterans affairs normative aging study
    Konstantinos N. Aronis, Ayse Sahin-Efe, John P. Chamberland, Avron Spiro, Pantel Vokonas, Christos S. Mantzoros
    Metabolism.2014; 63(6): 760.     CrossRef
  • The predictive value of the first-trimester maternal serum chemerin level for pre-eclampsia
    Qiu-Lian Xu, Min Zhu, Yan Jin, Nan Wang, Hai-Xia Xu, Li-Mei Quan, Shan-Shan Wang, Shan-Shan Li
    Peptides.2014; 62: 150.     CrossRef
  • Evaluation of Circulating Adipokines and Abdominal Obesity as Predictors of Significant Myocardial Ischemia Using Gated Single-Photon Emission Computed Tomography
    Chi-Sheng Hung, Yen-Wen Wu, Jei-Yie Huang, Pei-Ying Hsu, Ming-Fong Chen, Xin-Liang Ma
    PLoS ONE.2014; 9(5): e97710.     CrossRef
  • Towards an integrative approach to understanding the role of chemerin in human health and disease
    J. L. Rourke, H. J. Dranse, C. J. Sinal
    Obesity Reviews.2013; 14(3): 245.     CrossRef
  • The association between chemerin and homeostasis assessment of insulin resistance at baseline and after weight reduction via lifestyle modifications in young obese adults
    Mi Kyung Lee, Sang Hui Chu, Duk Chul Lee, Ki Yong An, Ji-Hye Park, Dong Il Kim, Jiyoung Kim, Sunghyun Hong, Jee Aee Im, Ji Won Lee, Justin Y. Jeon
    Clinica Chimica Acta.2013; 421: 109.     CrossRef
  • Elevated Chemerin Levels in Pakistani Men: An Interrelation with Metabolic Syndrome Phenotypes
    Syeda Sadia Fatima, Kiymet Bozaoglu, Rehana Rehman, Faiza Alam, Abdul Shakoor Memon, Pascale Chavatte-Palmer
    PLoS ONE.2013; 8(2): e57113.     CrossRef
  • Chemerin: a potential endocrine link between obesity and type 2 diabetes
    Alexandra A. Roman, Sebastian D. Parlee, Christopher J. Sinal
    Endocrine.2012; 42(2): 243.     CrossRef
  • Elastase and Tryptase Govern TNFα-Mediated Production of Active Chemerin by Adipocytes
    Sebastian D. Parlee, Jenna O. McNeil, Shanmugam Muruganandan, Christopher J. Sinal, Kerry B. Goralski, Charaf Benarafa
    PLoS ONE.2012; 7(12): e51072.     CrossRef
  • Potential association between coronary artery disease and the inflammatory biomarker YKL-40 in asymptomatic patients with type 2 diabetes mellitus
    Hyun Min Kim, Byung-Wan Lee, Young-Mi Song, Won Jin Kim, Hyuk-Jae Chang, Dong-Hoon Choi, Hee Tae Yu, EunSeok Kang, Bong Soo Cha, Hyun Chul Lee
    Cardiovascular Diabetology.2012;[Epub]     CrossRef
  • The association of serum chemerin level with risk of coronary artery disease in Chinese adults
    Qun Yan, Yifei Zhang, Jie Hong, Weiqiong Gu, Meng Dai, Juan Shi, Ying Zhai, Weiqing Wang, Xiaoying Li, Guang Ning
    Endocrine.2012; 41(2): 281.     CrossRef
  • Epidemiology of Micro- and Macrovascular Complications of Type 2 Diabetes in Korea
    Jung Hee Kim, Dae Jung Kim, Hak Chul Jang, Sung Hee Choi
    Diabetes & Metabolism Journal.2011; 35(6): 571.     CrossRef
  • Chemerin: A Novel Link between Inflammation and Atherosclerosis?
    Eun-Jung Rhee
    Diabetes & Metabolism Journal.2011; 35(3): 216.     CrossRef

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