Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
2 "Joon Young Chang"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Review
Basic Research
Article image
Mitochondrial Stress and Mitokines: Therapeutic Perspectives for the Treatment of Metabolic Diseases
Benyuan Zhang, Joon Young Chang, Min Hee Lee, Sang-Hyeon Ju, Hyon-Seung Yi, Minho Shong
Diabetes Metab J. 2024;48(1):1-18.   Published online January 3, 2024
DOI: https://doi.org/10.4093/dmj.2023.0115
  • 3,449 View
  • 325 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDFPubReader   ePub   
Mitochondrial stress and the dysregulated mitochondrial unfolded protein response (UPRmt) are linked to various diseases, including metabolic disorders, neurodegenerative diseases, and cancer. Mitokines, signaling molecules released by mitochondrial stress response and UPRmt, are crucial mediators of inter-organ communication and influence systemic metabolic and physiological processes. In this review, we provide a comprehensive overview of mitokines, including their regulation by exercise and lifestyle interventions and their implications for various diseases. The endocrine actions of mitokines related to mitochondrial stress and adaptations are highlighted, specifically the broad functions of fibroblast growth factor 21 and growth differentiation factor 15, as well as their specific actions in regulating inter-tissue communication and metabolic homeostasis. Finally, we discuss the potential of physiological and genetic interventions to reduce the hazards associated with dysregulated mitokine signaling and preserve an equilibrium in mitochondrial stress-induced responses. This review provides valuable insights into the mechanisms underlying mitochondrial regulation of health and disease by exploring mitokine interactions and their regulation, which will facilitate the development of targeted therapies and personalized interventions to improve health outcomes and quality of life.

Citations

Citations to this article as recorded by  
  • Mitochondria: fundamental characteristics, challenges, and impact on aging
    Runyu Liang, Luwen Zhu, Yongyin Huang, Jia Chen, Qiang Tang
    Biogerontology.2024;[Epub]     CrossRef
Sulwon Lecture 2019
Pathophysiology
The Role of Growth Differentiation Factor 15 in Energy Metabolism
Joon Young Chang, Hyun Jung Hong, Seul Gi Kang, Jung Tae Kim, Ben Yuan Zhang, Minho Shong
Diabetes Metab J. 2020;44(3):363-371.   Published online June 29, 2020
DOI: https://doi.org/10.4093/dmj.2020.0087
  • 9,513 View
  • 246 Download
  • 17 Web of Science
  • 16 Crossref
AbstractAbstract PDFPubReader   

Growth differentiation factor 15 (GDF15) is receiving great interest beyond its role as an aging and disease-related biomarker. Recent discovery of its receptor, glial cell line-derived neurotrophic factor (GDNF) family receptor α-like (GFRAL), suggests a central role in appetite regulation. However, there is also considerable evidence that GDF15 may have peripheral activity through an as-of-yet undiscovered mode of action. This raises the question as to whether increased GDF15 induction during pathophysiologic conditions also suppresses appetite. The present review will briefly introduce the discovery of GDF15 and describe the different contexts under which GDF15 is induced, focusing on its induction during mitochondrial dysfunction. We will further discuss the metabolic role of GDF15 under various pathophysiological conditions and conclude with possible therapeutic applications.

Citations

Citations to this article as recorded by  
  • Growth differentiation factor-15 is an IFN-γ regulated mediator of infection-induced weight loss and the hepatic FGF21 response
    Jojo Reyes, Yanlin Zhao, Krushang Pandya, George S. Yap
    Brain, Behavior, and Immunity.2024; 116: 24.     CrossRef
  • Biomarkers of disability worsening in inactive primary progressive multiple sclerosis
    Maria-Elizabeth Baeva, Isabelle Tottenham, Marcus Koch, Carlos Camara-Lemarroy
    Journal of Neuroimmunology.2024; 387: 578268.     CrossRef
  • Tricarboxylic Acid Cycle Intermediates and Individual Ageing
    Natalia Kurhaluk
    Biomolecules.2024; 14(3): 260.     CrossRef
  • The implicated role of GDF15 in gastrointestinal cancer
    Yingqi Xue, Yan Zhang, Yale Su, Jiangqi Zhao, Daoquan Yu, Yunju Jo, Jongkil Joo, Hyun Joo Lee, Dongryeol Ryu, Shibo Wei
    European Journal of Clinical Investigation.2024;[Epub]     CrossRef
  • Correlation Between Growth Differentiation Factor-15 and Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus
    Yue Li, Yuhui Wang, Yonghong Cao, Xinxiu Zhang, Wu Dai, Yiran Zhao, Lei Zhang, Xiaofang Han
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 3019.     CrossRef
  • A long‐acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model
    Songmao Zheng, David Polidori, Yuanping Wang, Brian Geist, Xiefan Lin‐Schmidt, Jennifer L. Furman, Serena Nelson, Andrea R. Nawrocki, Simon A. Hinke
    Clinical and Translational Science.2023; 16(8): 1431.     CrossRef
  • GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway
    Samuel N. Breit, Rakesh Manandhar, Hong-Ping Zhang, Michelle Lee-Ng, David A. Brown, Vicky Wang-Wei Tsai
    Cell Metabolism.2023; 35(8): 1341.     CrossRef
  • Serum growth differentiation factor-15 (GDF-15) is a biomarker of cardiac manifestations in children with COVID-19
    Sally Raafat Ishak, Mona Mostafa El Ganzoury, Eman Mahmoud Fouda, Maha Ahmad Anwar, Amany Moustafa Kamal, Heba Mostafa Hamza, Nehad Ahmed Bakry
    European Journal of Medical Research.2023;[Epub]     CrossRef
  • Understanding the molecular basis of anorexia and tissue wasting in cancer cachexia
    Eunbyul Yeom, Kweon Yu
    Experimental & Molecular Medicine.2022; 54(4): 426.     CrossRef
  • Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults
    Wan-Hsuan Lu, Kelly Virecoulon Giudici, John E. Morley, Sophie Guyonnet, Angelo Parini, Geetika Aggarwal, Andrew D. Nguyen, Yan Li, Randall J. Bateman, Bruno Vellas, Philipe de Souto Barreto, Bruno Vellas, Sophie Guyonnet, Isabelle Carrié, Lauréane Brigit
    GeroScience.2022; 44(3): 1489.     CrossRef
  • The Potential Role of Growth Differentiation Factor 15 in COVID-19: A Corollary Subjective Effect or Not?
    Ahmad O. Babalghith, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Michel De Waard, Jean-Marc Sabatier, Hebatallah M. Saad, Gaber El-Saber Batiha
    Diagnostics.2022; 12(9): 2051.     CrossRef
  • Metformin and growth differentiation factor 15 (GDF15) in type 2 diabetes mellitus: A hidden treasure
    Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Eman Hassan Nadwa, Sarah M. Albogami, Mohammed Alorabi, Hebatallah M. Saad, Gaber El‐Saber Batiha
    Journal of Diabetes.2022; 14(12): 806.     CrossRef
  • Effects of Exercise Intervention on Mitochondrial Stress Biomarkers in Metabolic Syndrome Patients: A Randomized Controlled Trial
    Jae Seung Chang, Jun Namkung
    International Journal of Environmental Research and Public Health.2021; 18(5): 2242.     CrossRef
  • Neurological & psychological aspects of Barth syndrome: Clinical manifestations and potential pathogenic mechanisms
    Melissa Olivar-Villanueva, Mindong Ren, Colin K.L. Phoon
    Mitochondrion.2021; 61: 188.     CrossRef
  • The metabolic role of spermidine in obesity: Evidence from cells to community
    Yanee Choksomngam, Sintip Pattanakuhar, Nipon Chattipakorn, Siriporn C. Chattipakorn
    Obesity Research & Clinical Practice.2021; 15(4): 315.     CrossRef
  • The Role of GDF15 as a Myomitokine
    Kornelia Johann, Maximilian Kleinert, Susanne Klaus
    Cells.2021; 10(11): 2990.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP