Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) generation and their clearance by antioxidant defense systems. Transcription factor nuclear factor NF-E2-related factor 2 (Nrf2) plays an important role in maintaining the oxidative homeostasis by regulating multiple downstream antioxidants. Diabetes may up-regulate several antioxidants in the heart as a compensative mechanism at early stage, but at late stage, diabetes not only generates extra ROS and/or RNS but also impairs antioxidant capacity in the heart, including Nrf2. In an early study, we have established that Nrf2 protect the cardiac cells and heart from high level of glucose in vitro and hyperglycemia in vivo, and in the following study demonstrated the significant down-regulation of cardiac Nrf2 expression in diabetic animals and patients. Using Nrf2-KO mice or Nrf2 inducers, blooming evidence has indicated the important protection by Nrf2 from cardiac pathogenesis in the diabetes. Therefore, this brief review summarizes the status of studies on Nrf2's role in preventing DCM and even other complications, the need for new and safe Nrf2 inducer screening and the precaution for the undesirable side of Nrf2 under certain conditions.

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Citations to this article as recorded by  

• Beyond Hepatoprotection—The Cardioprotective Effects of Bicyclol in Diabetes
  Arun Samidurai, Rakesh C. Kukreja
  Cardiovascular Drugs and Therapy.2024; 38(3): 411.     CrossRef
• Natural Products and Health
  Joanna Bartkowiak-Wieczorek, Edyta Mądry
  Nutrients.2024; 16(3): 415.     CrossRef
• Nrf2 prevents diabetic cardiomyopathy via antioxidant effect and normalization of glucose and lipid metabolism in the heart
  Ge Yang, Qihe Zhang, Chao Dong, Guowen Hou, Jinjie Li, Xin Jiang, Ying Xin
  Journal of Cellular Physiology.2024;[Epub]     CrossRef
• 3,4′,5-Trimethoxy-trans-stilbene ameliorates hepatic insulin resistance and oxidative stress in diabetic obese mice through insulin and Nrf2 signaling pathways
  Yi Tan, Chunxiu Zhou, Lingchao Miao, Xutao Zhang, Haroon Khan, Baojun Xu, Wai San Cheang
  Food & Function.2024; 15(6): 2996.     CrossRef
• The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review
  Wencan Li, Xiang Liu, Zheng Liu, Qichang Xing, Renzhu Liu, Qinxuan Wu, Yixiang Hu, Jiani Zhang
  Frontiers in Pharmacology.2024;[Epub]     CrossRef
• Phycocyanin attenuates skeletal muscle damage and fatigue via modulation of Nrf2 and IRS-1/AKT/mTOR pathway in exercise-induced oxidative stress in rats
  Sayomphu Puengpan, Amnat Phetrungnapha, Sarawut Sattayakawee, Sakara Tunsophon, Keisuke Hitachi
  PLOS ONE.2024; 19(9): e0310138.     CrossRef
• Cannabinoid 2 Receptor Activation Protects against Diabetic Cardiomyopathy through Inhibition of AGE/RAGE-Induced Oxidative Stress, Fibrosis, and Inflammasome Activation
  Hebaallah Mamdouh Hashiesh, Sheikh Azimullah, Mohamed Fizur Nagoor Meeran, Dhanya Saraswathiamma, Seenipandi Arunachalam, Niraj Kumar Jha, Bassem Sadek, Ernest Adeghate, Gautam Sethi, Alia Albawardi, Saeeda Al Marzooqi, Shreesh Ojha
  The Journal of Pharmacology and Experimental Therapeutics.2024; 391(2): 241.     CrossRef
• From Microcirculation to Aging-Related Diseases: A Focus on Endothelial SIRT1
  Martin Law, Pei-Chun Wang, Zhong-Yan Zhou, Yu Wang
  Pharmaceuticals.2024; 17(11): 1495.     CrossRef
• Concerning influences of micro/nano plastics on female reproductive health: focusing on cellular and molecular pathways from animal models to human studies
  Hasti Balali, Ali Morabbi, Mohammad Karimian
  Reproductive Biology and Endocrinology.2024;[Epub]     CrossRef
• Modulation of PPAR-γ/Nrf2 and AGE/RAGE signaling contributes to the chrysin cardioprotection against myocardial damage following ischemia/reperfusion in diabetic rats
  Neha Rani, Dharamvir Singh Arya
  Journal of Pharmacy and Pharmacology.2024;[Epub]     CrossRef
• Natural compounds protect against the pathogenesis of osteoarthritis by mediating the NRF2/ARE signaling
  Zhenyu Wu, Zhouxin Yang, Luying Liu, Yong Xiao
  Frontiers in Pharmacology.2023;[Epub]     CrossRef
• High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury
  Stanley Ibeh, Nour-Mounira Z. Bakkar, Fatima Ahmad, Judith Nwaiwu, Chloe Barsa, Sarine Mekhjian, Mohammad Amine Reslan, Ali H. Eid, Hayat Harati, Sanaa Nabha, Yehia Mechref, Ahmed F. El-Yazbi, Firas Kobeissy
  Life Sciences.2023; 314: 121316.     CrossRef
• The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK
  Jozaa Z. AlTamimi, Nora A. AlFaris, Ghedeir M. Alshammari, Reham I. Alagal, Dalal H. Aljabryn, Mohammed Abdo Yahya
  Nutrients.2023; 15(7): 1660.     CrossRef
• Caffeic Acid Phenethyl Ester and Caffeamide Derivatives Suppress Oral Squamous Cell Carcinoma Cells
  Yin-Hwa Shih, Chieh-Chieh Chen, Yueh-Hsiung Kuo, Lih-Jyh Fuh, Wan-Chen Lan, Tong-Hong Wang, Kuo-Chou Chiu, Thanh-Hien Vu Nguyen, Shih-Min Hsia, Tzong-Ming Shieh
  International Journal of Molecular Sciences.2023; 24(12): 9819.     CrossRef
• The Role of Asiatic Acid in Preventing Dental Pulp Inflammation: An in-vivo Study
  Arlina Nurhapsari, Risya Cilmiaty, Adi Prayitno, Bambang Purwanto, Soetrisno Soetrisno
  Clinical, Cosmetic and Investigational Dentistry.2023; Volume 15: 109.     CrossRef
• Dexmedetomidine ameliorates diabetic cardiomyopathy by inhibiting ferroptosis through the Nrf2/GPX4 pathway
  Fan Li, Zhenfei Hu, Yidan Huang, Haiting Zhan
  Journal of Cardiothoracic Surgery.2023;[Epub]     CrossRef
• Metformin-mediated epigenetic modifications in diabetes and associated conditions: Biological and clinical relevance
  Roberta Giordo, Anna Maria Posadino, Arduino Aleksander Mangoni, Gianfranco Pintus
  Biochemical Pharmacology.2023; 215: 115732.     CrossRef
• Transient receptor potential vanilloid type 1: cardioprotective effects in diabetic models
  Jiaqi Bao, Zhicheng Gao, Yilan Hu, Lifang Ye, Lihong Wang
  Channels.2023;[Epub]     CrossRef
• Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats
  Mohammad Raish, Ajaz Ahmad, Yousef A. Bin Jardan, Mudassar Shahid, Khalid M. Alkharfy, Abdul Ahad, Mushtaq Ahmad Ansari, Ibrahim Abdelsalam Abdelrahman, Fahad I. Al-Jenoobi
  Biomedicine & Pharmacotherapy.2022; 145: 112412.     CrossRef
• Recent Advances in KEAP1/NRF2-Targeting Strategies by Phytochemical Antioxidants, Nanoparticles, and Biocompatible Scaffolds for the Treatment of Diabetic Cardiovascular Complications
  Andrea Rampin, Michele Carrabba, Martina Mutoli, Charlotte L. Eman, Gianluca Testa, Paolo Madeddu, Gaia Spinetti
  Antioxidants & Redox Signaling.2022; 36(10-12): 707.     CrossRef
• Exercise and Urtica Dioica extract ameliorate mitochondrial function and the expression of cardiac muscle Nuclear Respiratory Factor 2 and Peroxisome proliferator-activated receptor Gamma Coactivator 1-alpha in STZ-induced diabetic rats
  Seyyedeh Masoumeh Seyydi, Asghar Tofighi, Masoud Rahmati, Javad Tolouei Azar
  Gene.2022; 822: 146351.     CrossRef
• 3,3′,4,5′-Tetramethoxy-trans-stilbene Improves Insulin Resistance by Activating the IRS/PI3K/Akt Pathway and Inhibiting Oxidative Stress
  Yi Tan, Lingchao Miao, Jianbo Xiao, Wai San Cheang
  Current Issues in Molecular Biology.2022; 44(5): 2175.     CrossRef
• The Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling
  Yiwei Gao, Wu Liu, Xin Su, Xinyi Li, Fangning Yu, Ning Zhang, Yuli Huang
  Oxidative Medicine and Cellular Longevity.2022; 2022: 1.     CrossRef
• Cardioprotective Effects and in-silico Antioxidant Mechanism of L-Ergothioneine in Experimental Type-2 Diabetic Rats
  Ayobami Dare, Ahmed A Elrashedy, Mahendra L. Channa, Anand Nadar
  Cardiovascular & Hematological Agents in Medicinal Chemistry.2022; 20(2): 133.     CrossRef
• Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease
  Lai-Hua Xie, Nadezhda Fefelova, Sri Harika Pamarthi, Judith K. Gwathmey
  Cells.2022; 11(17): 2726.     CrossRef
• Cardiac adaptation and cardioprotection against arrhythmias and ischemia-reperfusion injury in mammalian hibernators
  Lai-Hua Xie, Judith K. Gwathmey, Zhenghang Zhao
  Pflügers Archiv - European Journal of Physiology.2021; 473(3): 407.     CrossRef
• Cardioprotective Effect of Glycyrrhizin on Myocardial Remodeling in Diabetic Rats
  Vikram Thakur, Narah Alcoreza, Monica Delgado, Binata Joddar, Munmun Chattopadhyay
  Biomolecules.2021; 11(4): 569.     CrossRef
• Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy
  Nikole J. Byrne, Namakkal S. Rajasekaran, E Dale Abel, Heiko Bugger
  Free Radical Biology and Medicine.2021; 169: 317.     CrossRef
• Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway
  Feng Fu, Chaoyang Liu, Rui Shi, Man Li, Min Zhang, Yanyan Du, Qiaojuan Wang, Jun Li, Guoen Wang, Jianming Pei, Mingge Ding
  Antioxidants & Redox Signaling.2021; 35(8): 618.     CrossRef
• Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice
  Yuanjiu Lei, Camila Guerra Martinez, Sylvia Torres-Odio, Samantha L. Bell, Christine E. Birdwell, Joshua D. Bryant, Carl W. Tong, Robert O. Watson, Laura Ciaccia West, A. Phillip West
  Science Advances.2021;[Epub]     CrossRef
• The potential role of Keap1-Nrf2 pathway in the pathogenesis of Alzheimer’s disease, type 2 diabetes, and type 2 diabetes-related Alzheimer’s disease
  Ling He, Yi Sun
  Metabolic Brain Disease.2021; 36(7): 1469.     CrossRef
• The impact of mitochondria on cancer treatment resistance
  Michelle van der Merwe, Gustav van Niekerk, Carla Fourie, Manisha du Plessis, Anna-Mart Engelbrecht
  Cellular Oncology.2021; 44(5): 983.     CrossRef
• Therapeutic Approaches Targeting Proteostasis in Kidney Disease and Fibrosis
  Jia-Huang Chen, Chia-Hsien Wu, Chih-Kang Chiang
  International Journal of Molecular Sciences.2021; 22(16): 8674.     CrossRef
• Coronary Large Conductance Ca2+-Activated K+ Channel Dysfunction in Diabetes Mellitus
  Tong Lu, Hon-Chi Lee
  Frontiers in Physiology.2021;[Epub]     CrossRef
• Ferroptosis: New Dawn for Overcoming the Cardio-Cerebrovascular Diseases
  Meng-Yi Luo, Jian-Hui Su, Shao-Xin Gong, Na Liang, Wen-Qian Huang, Wei Chen, Ai-Ping Wang, Ying Tian
  Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
• Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy
  Zuowei Pei, Xiang Wang, Chenguang Yang, Min Dong, Fang Wang, Juan Gambini
  Oxidative Medicine and Cellular Longevity.2021;[Epub]     CrossRef
• Hydrogen sulfide mitigates myocardial inflammation by inhibiting nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation in diabetic rats
  Qiang Jia, Shomaila Mehmood, Xiaofen Liu, Shanfeng Ma, Rui Yang
  Experimental Biology and Medicine.2020; 245(3): 221.     CrossRef
• Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance
  Rafael C. M. C. Silva, Leonardo H. Travassos, Claudia N. Paiva, Marcelo T. Bozza, Marc-Jan Gubbels
  PLOS Pathogens.2020; 16(7): e1008599.     CrossRef
• Distinct Approaches of Raloxifene: Its Far-Reaching Beneficial Effects Implicating the HO-System
  Denise Börzsei, Renáta Szabó, Alexandra Hoffmann, Médea Veszelka, Imre Pávó, Zsolt Turcsán, Csaba Viczián, Krisztina Kupai, Csaba Varga, Anikó Pósa
  Biomolecules.2020; 10(3): 375.     CrossRef
• The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy
  Humna Bhagani, Suzanne A. Nasser, Ali Dakroub, Ahmed F. El-Yazbi, Assaad A. Eid, Firas Kobeissy, Gianfranco Pintus, Ali H. Eid
  International Journal of Molecular Sciences.2020; 21(14): 4962.     CrossRef
• The Effects of Dietary Supplements that Overactivate the Nrf2/ARE System
  Robert E. Smith
  Current Medicinal Chemistry.2020; 27(13): 2077.     CrossRef
• Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats
  Jierong Luo, Dan Yan, Sisi Li, Shiming Liu, Fei Zeng, Chi Wai Cheung, Hong Liu, Michael G. Irwin, Huansen Huang, Zhengyuan Xia
  Journal of Cellular and Molecular Medicine.2020; 24(2): 1760.     CrossRef
• Rg1 protects H9C2 cells from high glucose‐/palmitate‐induced injury via activation of AKT/GSK‐3β/Nrf2 pathway
  Haitao Yu, Juan Zhen, Yang Yang, Jian Du, Jiyan Leng, Qian Tong
  Journal of Cellular and Molecular Medicine.2020; 24(14): 8194.     CrossRef
• Ranolazine protects against diabetic cardiomyopathy by activating the NOTCH1/NRG1 pathway
  Xi Chen, Long Ren, Xing Liu, Xi Sun, Chaorun Dong, Yanan Jiang, Ying Qin, Huan Qu, Jinfeng Jiao, Shuo Wang, Yunlong Bai, Baofeng Yang
  Life Sciences.2020; 261: 118306.     CrossRef
• Low Concentration of Withaferin a Inhibits Oxidative Stress-Mediated Migration and Invasion in Oral Cancer Cells
  Tzu-Jung Yu, Jen-Yang Tang, Fu Ou-Yang, Yen-Yun Wang, Shyng-Shiou F. Yuan, Kevin Tseng, Li-Ching Lin, Hsueh-Wei Chang
  Biomolecules.2020; 10(5): 777.     CrossRef
• Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose‐Induced Oxidative Stress in HUVECs
  Ting-Ting Tian, Qi-Rui Li, Shi-Quan Gan, Chu-Rui Chang, Xiang-Chun Shen, Shao-Hsuan Kao
  Evidence-Based Complementary and Alternative Medicine.2020;[Epub]     CrossRef
• Deneysel Diyabet Oluşturulan Sıçanlarda Kalp ve İskelet Kası Nrf2 Yapımı ve Oksidatif Stres Üzerine Melatoninin Etkisinin İncelenmesi
  Salim ÖZENOĞLU, İnci TURAN, Hale SAYAN ÖZAÇMAK, Veysel Haktan ÖZAÇMAK
  Turkish Journal of Diabetes and Obesity.2020; 4(1): 46.     CrossRef
• Nicorandil alleviates apoptosis in diabetic cardiomyopathy through PI3K/Akt pathway
  Xuyang Wang, Jinyu Pan, Dian Liu, Mingjun Zhang, Xiaowei Li, Jingjing Tian, Ming Liu, Tao Jin, Fengshuang An
  Journal of Cellular and Molecular Medicine.2019; 23(8): 5349.     CrossRef
• Bailcalin Protects against Diabetic Cardiomyopathy through Keap1/Nrf2/AMPK-Mediated Antioxidative and Lipid-Lowering Effects
  Ran Li, Yuan Liu, Ying-guang Shan, Lu Gao, Fang Wang, Chun-guang Qiu
  Oxidative Medicine and Cellular Longevity.2019; 2019: 1.     CrossRef
• Omega 3 rich diet modulates energy metabolism via GPR120-Nrf2 crosstalk in a novel antioxidant mouse model
  Deborah Amos, Carla Cook, Nalini Santanam
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2019; 1864(4): 466.     CrossRef
• Increased placental expressions of nuclear factor erythroid 2–related factor 2 and antioxidant enzymes in gestational diabetes: Protective mechanisms against the placental oxidative stress?
  Balachandiran Manoharan, Zachariah Bobby, Gowri Dorairajan, Sajini Elizabeth Jacob, Victorraj Gladwin, Vickneshwaran Vinayagam, Rajaa Muthu Packirisamy
  European Journal of Obstetrics & Gynecology and Reproductive Biology.2019; 238: 78.     CrossRef
• Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system
  Aleksandra Golonko, Tomasz Pienkowski, Renata Swislocka, Ryszard Lazny, Marek Roszko, Wlodzimierz Lewandowski
  European Journal of Medicinal Chemistry.2019; 167: 291.     CrossRef
• Hydrogen sulfide-mediated regulation of cell death signaling ameliorates adverse cardiac remodeling and diabetic cardiomyopathy
  Sumit Kar, Tyler N. Kambis, Paras K. Mishra
  American Journal of Physiology-Heart and Circulatory Physiology.2019; 316(6): H1237.     CrossRef
• Genomic and Genetic Approaches to Deciphering Acute Respiratory Distress Syndrome Risk and Mortality
  Heather Lynn, Xiaoguang Sun, Nancy Casanova, Manuel Gonzales-Garay, Christian Bime, Joe G.N. Garcia
  Antioxidants & Redox Signaling.2019; 31(14): 1027.     CrossRef
• Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice
  Gobinath Shanmugam, Anil Kumar Challa, Silvio H. Litovsky, Asokan Devarajan, Ding Wang, Dean P. Jones, Victor M. Darley-Usmar, Namakkal Soorappan Rajasekaran
  Redox Biology.2019; 27: 101212.     CrossRef
• Effects of PP2A/Nrf2 on experimental diabetes mellitus-related cardiomyopathy by regulation of autophagy and apoptosis through ROS dependent pathway
  Yanhui Guan, Lichun Zhou, Yu Zhang, Huiqin Tian, Anqi Li, Xiuzhen Han
  Cellular Signalling.2019; 62: 109339.     CrossRef
• An Aza resveratrol–chalcone derivative 6b protects mice against diabetic cardiomyopathy by alleviating inflammation and oxidative stress
  Shengban You, Jianchang Qian, Chuchu Sun, Hailing Zhang, Shiju Ye, Taiwei Chen, Zheng Xu, Jingying Wang, Weijian Huang, Guang Liang
  Journal of Cellular and Molecular Medicine.2018; 22(3): 1931.     CrossRef
• Oxidative Stress in Mesenchymal Stem Cell Senescence: Regulation by Coding and Noncoding RNAs
  Rosa Vono, Eva Jover Garcia, Gaia Spinetti, Paolo Madeddu
  Antioxidants & Redox Signaling.2018; 29(9): 864.     CrossRef
• An overview of the emerging interface between cardiac metabolism, redox biology and the circadian clock
  Rodrigo A. Peliciari-Garcia, Victor Darley-Usmar, Martin E. Young
  Free Radical Biology and Medicine.2018; 119: 75.     CrossRef
• Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo
  Yue Guo, Xiaodong Zhuang, Zena Huang, Jing Zou, Daya Yang, Xun Hu, Zhimin Du, Lichun Wang, Xinxue Liao
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2018; 1864(1): 238.     CrossRef
• Paradoxical cardiotoxicity of intraperitoneally-injected epigallocatechin gallate preparation in diabetic mice
  Nora O. Abdel Rasheed, Lamiaa A. Ahmed, Dalaal M. Abdallah, Bahia M. El-Sayeh
  Scientific Reports.2018;[Epub]     CrossRef
• Oxidative stress-induced miR-27a targets the redox gene nuclear factor erythroid 2-related factor 2 in diabetic embryopathy
  Yang Zhao, Daoyin Dong, E. Albert Reece, Ashley R. Wang, Peixin Yang
  American Journal of Obstetrics and Gynecology.2018; 218(1): 136.e1.     CrossRef
• Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications
  Zhihua Wang, Sheng Yuan, Yanbing Li, Zhe Zhang, Wei Xiao, Dan Tang, Kaihe Ye, Zhijun Liu, Congcong Wang, Yixiong Zheng, Hong Nie, Heru Chen
  Biochemical Pharmacology.2018; 150: 54.     CrossRef
• Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart
  Hong Yang, Anyun Feng, Sundong Lin, Lechu Yu, Xiufei Lin, Xiaoqing Yan, Xuemian Lu, Chi Zhang
  Cell Death & Disease.2018;[Epub]     CrossRef
• Salusin-β contributes to oxidative stress and inflammation in diabetic cardiomyopathy
  Ming-Xia Zhao, Bing Zhou, Li Ling, Xiao-Qing Xiong, Feng Zhang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
  Cell Death & Disease.2017; 8(3): e2690.     CrossRef
• Role of Nrf2 Signaling in the Regulation of Vascular BK Channel β1 Subunit Expression and BK Channel Function in High-Fat Diet–Induced Diabetic Mice
  Tong Lu, Xiaojing Sun, Yong Li, Qiang Chai, Xiao-Li Wang, Hon-Chi Lee
  Diabetes.2017; 66(10): 2681.     CrossRef
• Regulation of vascular large-conductance calcium-activated potassium channels by Nrf2 signalling
  Yong Li, Xiao-Li Wang, Xiaojing Sun, Qiang Chai, Jingchao Li, Benjamin Thompson, Win-Kuang Shen, Tong Lu, Hon-Chi Lee
  Diabetes and Vascular Disease Research.2017; 14(4): 353.     CrossRef
• Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy
  Junlian Gu, Yanli Cheng, Hao Wu, Lili Kong, Shudong Wang, Zheng Xu, Zhiguo Zhang, Yi Tan, Bradley B. Keller, Honglan Zhou, Yuehui Wang, Zhonggao Xu, Lu Cai
  Diabetes.2017; 66(2): 529.     CrossRef
• Kimchi methanol extracts attenuate hepatic steatosis induced by high cholesterol diet in low-density lipoprotein receptor knockout mice through inhibition of endoplasmic reticulum stress
  Minji Woo, Mijeong Kim, Jeong Sook Noh, Yeong Ok Song
  Journal of Functional Foods.2017; 32: 218.     CrossRef
• Aspalathin Protects the Heart against Hyperglycemia-Induced Oxidative Damage by Up-Regulating Nrf2 Expression
  Phiwayinkosi Dludla, Christo Muller, Elizabeth Joubert, Johan Louw, M. Essop, Kwazi Gabuza, Samira Ghoor, Barbara Huisamen, Rabia Johnson
  Molecules.2017; 22(1): 129.     CrossRef
• Intermittent hypoxia-induced cardiomyopathy and its prevention by Nrf2 and metallothionein
  Shanshan Zhou, Xia Yin, Jingpeng Jin, Yi Tan, Daniel J. Conklin, Ying Xin, Zhiguo Zhang, Weixia Sun, Taixing Cui, Jun Cai, Yang Zheng, Lu Cai
  Free Radical Biology and Medicine.2017; 112: 224.     CrossRef
• Inhibitory effects of rosmarinic acid on pterygium epithelial cells through redox imbalance and induction of extrinsic and intrinsic apoptosis
  Ya-Yu Chen, Chia-Fang Tsai, Ming-Chu Tsai, Yu-Wen Hsu, Fung-Jou Lu
  Experimental Eye Research.2017; 160: 96.     CrossRef
• Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus
  Anne Lejay, Fei Fang, Rohan John, Julie A.D. Van, Meredith Barr, Fabien Thaveau, Nabil Chakfe, Bernard Geny, James W. Scholey
  Journal of Molecular and Cellular Cardiology.2016; 91: 11.     CrossRef
• The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases
  Robert Smith, Kevin Tran, Cynthia Smith, Miranda McDonald, Pushkar Shejwalkar, Kenji Hara
  Diseases.2016; 4(4): 34.     CrossRef
• Prohibitin overexpression improves myocardial function in diabetic cardiomyopathy
  Wen-qian Dong, Min Chao, Qing-hua Lu, Wei-li Chai, Wei Zhang, Xue-ying Chen, Er-shun Liang, Ling-bo Wang, Hong-liang Tian, Yu-guo Chen, Ming-xiang Zhang
  Oncotarget.2016; 7(1): 66.     CrossRef
• Restoration of Nrf2 Signaling Normalizes the Regenerative Niche
  Marc A. Soares, Oriana D. Cohen, Yee Cheng Low, Rita A. Sartor, Trevor Ellison, Utkarsh Anil, Lavinia Anzai, Jessica B. Chang, Pierre B. Saadeh, Piul S. Rabbani, Daniel J. Ceradini
  Diabetes.2016; 65(3): 633.     CrossRef
• Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease
  Alexander T. Mikhailov, Mario Torrado
  Heart Failure Reviews.2016; 21(6): 783.     CrossRef
• Antioxidant Properties of Whole Body Periodic Acceleration (pGz)
  Arkady Uryash, Jorge Bassuk, Paul Kurlansky, Francisco Altamirano, Jose R. Lopez, Jose A. Adams, Guillermo López Lluch
  PLOS ONE.2015; 10(7): e0131392.     CrossRef
• Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice
  Ji-Young Ann, Hyeyoon Eo, Yunsook Lim
  Genes & Nutrition.2015;[Epub]     CrossRef
• Oxidative Stress and Human Hypertension: Vascular Mechanisms, Biomarkers, and Novel Therapies
  Augusto C. Montezano, Maria Dulak-Lis, Sofia Tsiropoulou, Adam Harvey, Ana M. Briones, Rhian M. Touyz
  Canadian Journal of Cardiology.2015; 31(5): 631.     CrossRef
• Haeme oxygenase signalling pathway: implications for cardiovascular disease
  Laura E. Fredenburgh, Allison A. Merz, Susan Cheng
  European Heart Journal.2015; 36(24): 1512.     CrossRef