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Links between Thyroid Disorders and Glucose Homeostasis
Young Sil Eom, Jessica R. Wilson, Victor J. Bernet
Diabetes Metab J. 2022;46(2):239-256.   Published online March 24, 2022
DOI: https://doi.org/10.4093/dmj.2022.0013
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  • 24 Web of Science
  • 21 Crossref
AbstractAbstract PDFPubReader   ePub   
Thyroid disorders and diabetes mellitus often coexist and are closely related. Several studies have shown a higher prevalence of thyroid disorders in patients with diabetes mellitus and vice versa. Thyroid hormone affects glucose homeostasis by impacting pancreatic β-cell development and glucose metabolism through several organs such as the liver, gastrointestinal tract, pancreas, adipose tissue, skeletal muscles, and the central nervous system. The present review discusses the effect of thyroid hormone on glucose homeostasis. We also review the relationship between thyroid disease and diabetes mellitus: type 1, type 2, and gestational diabetes, as well as guidelines for screening thyroid function with each disorder. Finally, we provide an overview of the effects of antidiabetic drugs on thyroid hormone and thyroid disorders.

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Diabetes Metab J : Diabetes & Metabolism Journal