Diabetes & Metabolism Journal

Original Article

Impact of HbA1c Criterion on the Detection of Subjects with Increased Risk for Diabetes among Health Check-Up Recipients in Korea: Hong-Kyu Kim, Sung-Jin Bae, Jaeone Choe; Diabetes Metab J. 2012;36(2):151-156. Published online April 17, 2012; DOI: https://doi.org/10.4093/dmj.2012.36.2.151

4,045 View
35 Download
18 Crossref

Background

We performed the study to examine the impact of hemoglobin A1c (HbA1c) criterion on the screening of increased risk for diabetes among health check-up subjects in Korea.

Methods

We retrospectively analyzed clinical and laboratory data of 37,754 Korean adults (age, 20 to 89 years; 41% women) which were measured during regular health check-ups. After excluding subjects with previously diagnosed diabetes mellitus (n=1,812) and with overt anemia (n=318), 35,624 subjects (21,201 men and 14,423 women) were included in the analysis.

Results

Among the 35,624 subjects, 11,316 (31.8%) subjects were categorized as increased risk for diabetes (IRD) by fasting plasma glucose (FPG) criteria, 6,531 (18.1%) subjects by HbA1c criteria, and 13,556 (38.1%) subjects by combined criteria. Therefore, although HbA1c criteria alone identifies 42% [(11,316-6,531)/11,316] fewer subjects with IRD than does FPG criteria, about 20% [(13,556-11,316)/11,316] more subjects could be detected by including new HbA1c criteria in addition to FPG criteria. Among the 13,556 subjects with IRD, 7,025 (51.8%) met FPG criteria only, 2,240 (16.5%) met HbA1c criteria only, and 4,291 (31.7%) met both criteria. Among subjects with impaired fasting glucose, 65% were normal, 32% were IRD, and 3% were diabetes by HbA1c criterion. In receiver operating characteristic curve analysis, cutoff point of HbA1c with optimal sensitivity and specificity for identifying IRD was 5.4%.

Conclusion

Although HbA1c criteria alone identifies fewer subjects with IRD than does FPG criteria, about 20% more could be detected by addition of HbA1c criteria. Further studies are needed to define optimal cutoff point of HbA1c and to establish screening and management guidelines for IRD.

Citations

Citations to this article as recorded by

Measuring the Burden of Disease in Korea Using Disability-Adjusted Life Years (2008–2020)
Yoon-Sun Jung, Young-Eun Kim, Minsu Ock, Seok-Jun Yoon
Journal of Korean Medical Science.2024;[Epub] CrossRef
The Relationship Between HbA1c and 25-hidroxy Vitamin D Levels in Adult Diabetic Patients
Mehmet ÖZDİN, Durhasan MUNDAN
Van Sağlık Bilimleri Dergisi.2023; 16(1): 25. CrossRef
Association between Prediabetes and Meal Patterns Related to Meal Sharing among Korean Young Adults: Eighth Korean National Health and Nutrition Examination Survey, 2019–2020
Saebom Kim, Sehee Kim, Youngmin Kim, Seonmi Seo, Yu Jin Chung, Sam Cheol Kim
Korean Journal of Family Practice.2023; 13(3): 179. CrossRef
Does reviewing fasting plasma glucose results patterns before glycosylated hemoglobin testing in type-2 diabetic patients lead to better testing decision?
Wichaporn Intharachuti, Jiruth Sriratanaban
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(3): 2080. CrossRef
Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia
Bernd Richter, Bianca Hemmingsen, Maria-Inti Metzendorf, Yemisi Takwoingi
Cochrane Database of Systematic Reviews.2018;[Epub] CrossRef
Evaluation of different ranges of LH:FSH ratios in polycystic ovarian syndrome (PCOS) – Clinical based case control study
N.A. Malini, K. Roy George
General and Comparative Endocrinology.2018; 260: 51. CrossRef
The Cutoff Value of HbA1c in Predicting Diabetes and Impaired Fasting Glucose
Seyoung Kwon, Youngak Na
The Korean Journal of Clinical Laboratory Science.2017; 49(2): 114. CrossRef
Risk of progression to diabetes from prediabetes defined by HbA1c or fasting plasma glucose criteria in Koreans
Chul-Hee Kim, Hong-Kyu Kim, Eun-Hee Kim, Sung-Jin Bae, Jaewon Choe, Joong-Yeol Park
Diabetes Research and Clinical Practice.2016; 118: 105. CrossRef
Comparison of the clinical characteristics of diabetes mellitus diagnosed using fasting plasma glucose and haemoglobin A1c: The 2011 Korea National Health and Nutrition Examination Survey
Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Chang Beom Lee, Sung-Hee Ihm
Diabetes Research and Clinical Practice.2016; 113: 23. CrossRef
Association of prediabetes, defined by fasting glucose, HbA1c only, or combined criteria, with the risk of cardiovascular disease in Koreans
Hong‐Kyu Kim, Jung Bok Lee, Seon Ha Kim, Min‐Woo Jo, Eun Hee Kim, Jenie Yoonoo Hwang, Sung Jin Bae, Chang Hee Jung, Woo Je Lee, Joong‐Yeol Park, Gyung‐Min Park, Young‐Hak Kim, Jaewon Choe
Journal of Diabetes.2016; 8(5): 657. CrossRef
Fasting plasma glucose concentrations for specified HbA1c goals in Korean populations: data from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2, 2011)
Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Chang Beom Lee, Sung-Hee Ihm
Diabetology & Metabolic Syndrome.2016;[Epub] CrossRef
Impact of hemoglobin A1c‐based criterion on diagnosis of prediabetes: The Korea National Health and Nutrition Examination Survey 2011
Chul‐Hee Kim, Hong‐Kyu Kim, Bo‐Yeon Kim, Chan‐Hee Jung, Ji‐Oh Mok, Sung‐Koo Kang
Journal of Diabetes Investigation.2015; 6(1): 51. CrossRef
Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants
G Danaei, S Fahimi, Y Lu, B Zhou, K Hajifathalian, M Di Cesare, WC Lo, B Reis-Santos, MJ Cowan, JE Shaw, J Bentham, JK Lin, H Bixby, D Magliano, P Bovet, JJ Miranda, YH Khang, GA Stevens, LM Riley, MK Ali, M Ezzati, ZA Abdeen, KA Kadir, M Abu-Rmeileh, B A
The Lancet Diabetes & Endocrinology.2015; 3(8): 624. CrossRef
Prediabetes is not independently associated with microalbuminuria in Korean general population: The Korea National Health and Nutrition Examination Survey 2011–2012 (KNHANES V-2,3)
Chul-Hee Kim, Kyu-Jin Kim, Bo-Yeon Kim, Chan-Hee Jung, Ji-Oh Mok, Sung-Koo Kang, Hong-Kyu Kim
Diabetes Research and Clinical Practice.2014; 106(2): e18. CrossRef
Estimation of blood glucose by non-invasive infrared thermography for diagnosis of type 2 diabetes: An alternative for blood sample extraction
S. Sivanandam, M. Anburajan, B. Venkatraman, M. Menaka, D. Sharath
Molecular and Cellular Endocrinology.2013; 367(1-2): 57. CrossRef
Comparison of glycated hemoglobin with fasting plasma glucose in definition of glycemic component of the metabolic syndrome in an Iranian population
Mohsen Janghorbani, Masoud Amini
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2012; 6(3): 136. CrossRef
Usefulness of Glycated Hemoglobin as Diagnostic Criteria for Metabolic Syndrome
Sang Hyun Park, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
Journal of Korean Medical Science.2012; 27(9): 1057. CrossRef
Letter: Impact of HbA1c Criterion on the Detection of Subjects with Increased Risk for Diabetes among Health Check-Up Recipients in Korea (Diabetes Metab J 2012;36:151-6)
Sung Hee Choi
Diabetes & Metabolism Journal.2012; 36(3): 251. CrossRef

First
Prev
Page of 1
Next
Last

Search