Diabetes & Metabolism Journal

Original Articles

Drug/Regimen
Efficacy and Safety of Omega-3 Fatty Acids in Patients Treated with Statins for Residual Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial: Ji Eun Jun, In-Kyung Jeong, Jae Myung Yu, Sung Rae Kim, In Kye Lee, Kyung-Ah Han, Sung Hee Choi, Soo-Kyung Kim, Hyeong Kyu Park, Ji-Oh Mok, Yong-ho Lee, Hyuk-Sang Kwon, So Hun Kim, Ho-Cheol Kang, Sang Ah Lee, Chang Beom Lee, Kyung Mook Choi, Sung-Ho Her, Won Yong Shin, Mi-Seung Shin, Hyo-Suk Ahn, Seung Ho Kang, Jin-Man Cho, Sang-Ho Jo, Tae-Joon Cha, Seok Yeon Kim, Kyung Heon Won, Dong-Bin Kim, Jae Hyuk Lee, Moon-Kyu Lee; Diabetes Metab J. 2020;44(1):78-90. Published online June 20, 2019; DOI: https://doi.org/10.4093/dmj.2018.0265

10,424 View
217 Download
7 Web of Science
8 Crossref

Abstract PDF Supplementary Material PubReader

Background

Cardiovascular risk remains increased despite optimal low density lipoprotein cholesterol (LDL-C) level induced by intensive statin therapy. Therefore, recent guidelines recommend non-high density lipoprotein cholesterol (non-HDL-C) as a secondary target for preventing cardiovascular events. The aim of this study was to assess the efficacy and tolerability of omega-3 fatty acids (OM3-FAs) in combination with atorvastatin compared to atorvastatin alone in patients with mixed dyslipidemia.

Methods

This randomized, double-blind, placebo-controlled, parallel-group, and phase III multicenter study included adults with fasting triglyceride (TG) levels ≥200 and <500 mg/dL and LDL-C levels <110 mg/dL. Eligible subjects were randomized to ATOMEGA (OM3-FAs 4,000 mg plus atorvastatin calcium 20 mg) or atorvastatin 20 mg plus placebo groups. The primary efficacy endpoints were the percent changes in TG and non-HDL-C levels from baseline at the end of treatment.

Results

After 8 weeks of treatment, the percent changes from baseline in TG (−29.8% vs. 3.6%, P<0.001) and non-HDL-C (−10.1% vs. 4.9%, P<0.001) levels were significantly greater in the ATOMEGA group (n=97) than in the atorvastatin group (n=103). Moreover, the proportion of total subjects reaching TG target of <200 mg/dL in the ATOMEGA group was significantly higher than that in the atorvastatin group (62.9% vs. 22.3%, P<0.001). The incidence of adverse events did not differ between the two groups.

Conclusion

The addition of OM3-FAs to atorvastatin improved TG and non-HDL-C levels to a significant extent compared to atorvastatin alone in subjects with residual hypertriglyceridemia.

Citations

Citations to this article as recorded by

Current trends in solving the problem of residual cardiovascular risk
N. Yu. Obedkova, A. A. Guslyakova, G. S. Mal, E. G. Obedkov
Meditsinskiy sovet = Medical Council.2024; (6): 155. CrossRef
Association Between Omega‐3 Fatty Acid Intake and Dyslipidemia: A Continuous Dose–Response Meta‐Analysis of Randomized Controlled Trials
Tianjiao Wang, Xin Zhang, Na Zhou, Yuxuan Shen, Biao Li, Bingshu E. Chen, Xinzhi Li
Journal of the American Heart Association.2023;[Epub] CrossRef
Nutraceutical support in the prevention and treatment of cardiovascular diseases
E. V. Gracheva, E. A. Starovoytova, E. S. Kulikov, N. A. Kirillova, S. V. Fedosenko, M. A. Balaganskaya, D. V. Kromka
Rational Pharmacotherapy in Cardiology.2023; 19(3): 298. CrossRef
Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial
Rehab H. Werida, Aalaa Ramzy, Youssri Nassief Ebrahim, Maged Wasfy Helmy
BMC Endocrine Disorders.2023;[Epub] CrossRef
The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence
Karla Paulina Luna-Castillo, Xochitl Citlalli Olivares-Ochoa, Rocío Guadalupe Hernández-Ruiz, Iris Monserrat Llamas-Covarrubias, Saraí Citlalic Rodríguez-Reyes, Alejandra Betancourt-Núñez, Barbara Vizmanos, Erika Martínez-López, José Francisco Muñoz-Valle
Nutrients.2022; 14(5): 1104. CrossRef
The effect of omega-3 fatty acids and its combination with statins on lipid profile in patients with hypertriglyceridemia: A systematic review and meta-analysis of randomized controlled trials
Yunjiao Yang, Wen Deng, Yanmei Wang, Tongyi Li, Yiding Chen, Cong Long, Qing Wen, Yue Wu, Qiu Chen
Frontiers in Nutrition.2022;[Epub] CrossRef
Comparison of the Efficacy and Safety of Atorvastatin 40 mg/ω-3 Fatty Acids 4 g Fixed-dose Combination and Atorvastatin 40 mg Monotherapy in Hypertriglyceridemic Patients who Poorly Respond to Atorvastatin 40 mg Monotherapy: An 8-week, Multicenter, Random
Jong Shin Woo, Soon Jun Hong, Dong Hoon Cha, Kee Sik Kim, Moo Hyun Kim, Jun-Won Lee, Myung Ho Jeong, Jin-Ok Jeong, Jun-Hee Lee, Doo Soo Jeon, Eun Joo Cho, Soon Kil Kim, Jun Kwan, Chang Gyu Park, Hae Young Lee, Taek Jong Hong, Jinho Shin, Ho Joong Youn, Do
Clinical Therapeutics.2021; 43(8): 1419. CrossRef
All-Cause Mortality and Cardiovascular Death between Statins and Omega-3 Supplementation: A Meta-Analysis and Network Meta-Analysis from 55 Randomized Controlled Trials
Jeongseon Kim, Tung Hoang, Ji-Myung Kim, So Young Bu, Jeong-Hwa Choi, Eunju Park, Seung-Min Lee, Eunmi Park, Ji Yeon Min, In Seok Lee, So Young Youn, Jee-Young Yeon
Nutrients.2020; 12(10): 3203. CrossRef

Complications
Association between Serum Cystatin C and Vascular Complications in Type 2 Diabetes Mellitus without Nephropathy: Hye Jeong Kim, Dong Won Byun, Kyoil Suh, Myung Hi Yoo, Hyeong Kyu Park; Diabetes Metab J. 2018;42(6):513-518. Published online October 15, 2018; DOI: https://doi.org/10.4093/dmj.2018.0006

4,051 View
53 Download
13 Web of Science
10 Crossref

Abstract PDF PubReader

Background

Recent studies have correlated serum cystatin C (CysC) with vascular complications, but few studies have investigated this correlation in diabetes patients without nephropathy. This study aimed to evaluate if higher serum CysC levels increase the risk for vascular complications in type 2 diabetes mellitus patients with normal renal function or mild renal impairment.

Methods

A total of 806 consecutive patients with type 2 diabetes mellitus who were admitted to the diabetes center of Soonchunhyang University Hospital for blood glucose control were retrospectively reviewed. Patients with nephropathy were excluded. Subjects were categorized into quartiles of serum CysC levels (Q1, ≤0.65 mg/L; Q2, 0.66 to 0.79 mg/L; Q3, 0.80 to 0.94 mg/L; and Q4, ≥0.95 mg/L).

Results

The proportion of patients with diabetic retinopathy (DR) (P for trend <0.001), coronary heart disease (CHD) (P for trend <0.001), and stroke (P for trend <0.001) increased across the serum CysC quartiles. After adjustment for confounding factors, the highest serum CysC level remained a significant risk factor for DR (odds ratio [OR], 1.929; 95% confidence interval [CI], 1.007 to 4.144; P=0.040). Compared with Q1, a significant positive association was observed between serum CysC and CHD in Q2 (OR, 7.321; 95% CI, 1.114 to 48.114; P=0.012), Q3 (OR, 6.027; 95% CI, 0.952 to 38.161; P=0.020), and Q4 (OR, 8.122; 95% CI, 1.258 to 52.453; P=0.007). No associations were observed between CysC and stroke after additional adjustment for confounding variables.

Conclusion

Serum CysC levels are independently associated with DR and CHD, suggesting that CysC may be useful for identifying type 2 diabetes mellitus patients without nephropathy who are at high risk for vascular complications.

Citations

Citations to this article as recorded by

Association of Estimated Glomerular Filtration Rate Trajectories with Atrial Fibrillation Risk in Populations with Normal or Mildly Impaired Renal Function
Chi Wang, Qian Xin, Junjuan Li, Jianli Wang, Siyu Yao, Miao Wang, Maoxiang Zhao, Shuohua Chen, Shouling Wu, Hao Xue
Kidney Diseases.2024; 10(4): 274. CrossRef
A systematic literature review of machine learning based risk prediction models for diabetic retinopathy progression
Tiwalade Modupe Usman, Yakub Kayode Saheed, Augustine Nsang, Abel Ajibesin, Sandip Rakshit
Artificial Intelligence in Medicine.2023; 143: 102617. CrossRef
Serum cystatin C for risk stratification of prediabetes and diabetes populations
Kun Xiong, Shiran Zhang, Pingting Zhong, Zhuoting Zhu, Yanping Chen, Wenyong Huang, Wei Wang
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(11): 102882. CrossRef
Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia
Jing Wei, Jincheng Zhang, Yanan Shi, Huiqin Zhang, Yan Wu
Open Medicine.2023;[Epub] CrossRef
Diagnostic circulating biomarkers to detect vision‐threatening diabetic retinopathy: Potential screening tool of the future?
Karen Frudd, Sobha Sivaprasad, Rajiv Raman, Subramanian Krishnakumar, Yeddula Rebecca Revathy, Patric Turowski
Acta Ophthalmologica.2022;[Epub] CrossRef
Association between circulating cystatin C and hyperuricemia: a cross-sectional study
Yanjun Guo, Hangkai Huang, Yishu Chen, Chao Shen, Chengfu Xu
Clinical Rheumatology.2022; 41(7): 2143. CrossRef
Multicenter Evaluation of Diagnostic Circulating Biomarkers to Detect Sight-Threatening Diabetic Retinopathy
Sarega Gurudas, Karen Frudd, Jayapal Jeya Maheshwari, Yeddula Rebecca Revathy, Sobha Sivaprasad, Shruthi Mahalakshmi Ramanathan, Vignesh Pooleeswaran, A. Toby Prevost, Eleni Karatsai, Sandra Halim, Shruti Chandra, Paul Nderitu, Dolores Conroy, Subramanian
JAMA Ophthalmology.2022; 140(6): 587. CrossRef
A Cross-Sectional Study of Serum and Urine Fluoride in Diabetes in Fluoride Exposed Population
Sai Deepika Ram Mohan, Shashidhar Kurpad Nagaraj, Raveesha Anjanappa, Muninarayana Chandrappa
Journal of Evolution of Medical and Dental Sciences.2021; 10(11): 798. CrossRef
Cystatin C predicts the risk of incident cerebrovascular disease in the elderly
Xin Zheng, Hong-da She, Qiao-xin Zhang, Tong Si, Ku-sheng Wu, Ying-xiu Xiao
Medicine.2021; 100(28): e26617. CrossRef
Proteinuria Is Associated with Carotid Artery Atherosclerosis in Non-Albuminuric Type 2 Diabetes: A Cross-Sectional Study
Jaehyun Bae, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
Journal of Clinical Medicine.2020; 9(1): 136. CrossRef

Editorial

Complications
Severe Hypoglycemia and Cardiovascular Disease in Type 2 Diabetes: Hyeong Kyu Park; Diabetes Metab J. 2015;39(6):478-480. Published online December 11, 2015; DOI: https://doi.org/10.4093/dmj.2015.39.6.478

3,112 View
34 Download
4 Web of Science
5 Crossref

PDF PubReader

Citations

Citations to this article as recorded by

Insulin-induced skin lipohypertrophies: A neglected cause of hypoglycemia in dialysed individuals with diabetes
Sandro Gentile, Ersilia Satta, Felice Strollo, Giuseppina Guarino, Carmine Romano, Teresa Della Corte, Carmelo Alfarone
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2021; 15(4): 102145. CrossRef
Insulin-Related Lipohypertrophy in Hemodialyzed Diabetic People: a Multicenter Observational Study and a Methodological Approach
Sandro Gentile, Felice Strollo, Ersilia Satta, Teresa Della Corte, Carmine Romano, Giuseppina Guarino
Diabetes Therapy.2019; 10(4): 1423. CrossRef
Postmeal increment in intact glucagon-like peptide 1 level, but not intact glucose-dependent insulinotropic polypeptide levels, is inversely associated with metabolic syndrome in patients with type 2 diabetes
Soyeon Yoo, Eun-Jin Yang, Sang Ah Lee, Gwanpyo Koh
Endocrine Research.2018; 43(1): 47. CrossRef
Myricetin: a potent approach for the treatment of type 2 diabetes as a natural class B GPCR agonist
Ying Li, Xuemin Zheng, Xiulin Yi, Changxiao Liu, Dexin Kong, Jianning Zhang, Min Gong
The FASEB Journal.2017; 31(6): 2603. CrossRef
Hypoglycemia and Health Costs
Yong-ho Lee, Gyuri Kim, Eun Seok Kang
The Journal of Korean Diabetes.2016; 17(1): 11. CrossRef

Letter

Letter: Predicting Mortality of Critically Ill Patients by Blood Glucose Levels (Diabetes Metab J 2013;37:385-90): Hyeong Kyu Park; Diabetes Metab J. 2013;37(6):484-485. Published online December 12, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.6.484

2,661 View
32 Download

PDF PubReader

Review

Resistin in Rodents and Humans: Hyeong Kyu Park, Rexford S. Ahima; Diabetes Metab J. 2013;37(6):404-414. Published online December 12, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.6.404

6,555 View
65 Download
123 Crossref

Abstract PDF PubReader

Obesity is characterized by excess accumulation of lipids in adipose tissue and other organs, and chronic inflammation associated with insulin resistance and an increased risk of type 2 diabetes. Obesity, type 2 diabetes, and cardiovascular diseases are major health concerns. Resistin was first discovered as an adipose-secreted hormone (adipokine) linked to obesity and insulin resistance in rodents. Adipocyte-derived resistin is increased in obese rodents and strongly related to insulin resistance. However, in contrast to rodents, resistin is expressed and secreted from macrophages in humans and is increased in inflammatory conditions. Some studies have also suggested an association between increased resistin levels and insulin resistance, diabetes and cardiovascular disease. Genetic studies have provided additional evidence for a role of resistin in insulin resistance and inflammation. Resistin appears to mediate the pathogenesis of atherosclerosis by promoting endothelial dysfunction, vascular smooth muscle cell proliferation, arterial inflammation, and formation of foam cells. Indeed, resistin is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. There is also growing evidence that elevated resistin is associated with the development of heart failure. This review will focus on the biology of resistin in rodents and humans, and evidence linking resistin with type 2 diabetes, atherosclerosis, and cardiovascular disease.

Citations

Citations to this article as recorded by

Resistin – A Plausible Therapeutic Target in the Pathogenesis of Psoriasis
Manupati Srikanth, Mahaboobkhan Rasool
Immunological Investigations.2024; 53(2): 115. CrossRef
MHO or MUO? White adipose tissue remodeling
Jing Yi Zhao, Li Juan Zhou, Kai Le Ma, Rui Hao, Min Li
Obesity Reviews.2024;[Epub] CrossRef
Resistin in endocrine pancreas of sheep: Presence and expression related to different diets
Margherita Maranesi, Elisa Palmioli, Cecilia Dall'Aglio, Daniele Marini, Polina Anipchenko, Elena De Felice, Paola Scocco, Francesca Mercati
General and Comparative Endocrinology.2024; 348: 114452. CrossRef
Adipocytokines levels as potential biomarkers for discriminating patients with a diagnosis of depressive disorder from healthy controls
Elżbieta Małujło-Balcerska, Tadeusz Pietras
Journal of Psychiatric Research.2024; 171: 163. CrossRef
Adipokines in atopic dermatitis: the link between obesity and atopic dermatitis
Shiyun Zhang, Bingjie Zhang, Yuehua Liu, Li Li
Lipids in Health and Disease.2024;[Epub] CrossRef
The Role of Adipokines in the Control of Pituitary Functions
Barbara Kaminska, Beata Kurowicka, Marta Kiezun, Kamil Dobrzyn, Katarzyna Kisielewska, Marlena Gudelska, Grzegorz Kopij, Karolina Szymanska, Barbara Zarzecka, Oguzhan Koker, Ewa Zaobidna, Nina Smolinska, Tadeusz Kaminski
Animals.2024; 14(2): 353. CrossRef
Adipokine imbalance and its role in the pathogenesis of novel coronavirus infection
I. D. Bespalova, U. M. Mitrichenko, V. V. Kalyuzhin, E. S. Koroleva, Yu. I. Koshchavtseva, D. S. Romanov, D. E. Pershina
Bulletin of Siberian Medicine.2024; 22(4): 164. CrossRef
Association of adipokine levels with obesity in periodontal health and disease: A systematic review with meta‐analysis and meta‐regression
Eswar Kandaswamy, Chun‐Teh Lee, Soumya Bardvalli Gururaj, Sachin Shivanaikar, Vinayak M. Joshi
Journal of Periodontal Research.2024; 59(4): 623. CrossRef
Role of epicardial adipose tissue in the pathogenesis of chronic inflammation in heart failure with preserved ejection fraction
O. N. Dzhioeva, Yu. S. Timofeev, V. A. Metelskaya, A. A. Bogdanova, T. Yu. Vedenikin, O. M. Drapkina
Cardiovascular Therapy and Prevention.2024; 23(3): 3928. CrossRef
Immunological roles for resistin and related adipokines in obesity-associated tumors
Jingxin Zhang, Enting Lu, Lei Deng, Yaoxuan Zhu, Xiaoqing Lu, Xinyuan Li, Fangmei Li, Yan Yan, Jing-Yan Han, Yin Li, Yi Zhang
International Immunopharmacology.2024; 142: 112911. CrossRef
Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation
David Ramiro-Cortijo, Pratibha Singh, Gloria Herranz Carrillo, Andrea Gila-Díaz, María A. Martín-Cabrejas, Camilia R. Martin, Silvia M. Arribas
Frontiers in Endocrinology.2023;[Epub] CrossRef
Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus
Branislava Rajkov, Marija Zdravković, Ana Ninić, Milica Brajković, Slobodan Klašnja, Vera Gardijan, Lidija Memon, Jelena Munjas, Marija Mihajlović, Vesna Spasojević- Kalimanovska, Vojislav Radosavljević, Miron Sopić
Sleep and Breathing.2023; 27(5): 2031. CrossRef
Fat-to-heart crosstalk in health and disease
Fleur Lodewijks, Timothy A. McKinsey, Emma L. Robinson
Frontiers in Genetics.2023;[Epub] CrossRef
Adipokines as Diagnostic and Prognostic Markers for the Severity of COVID-19
Thomas Grewal, Christa Buechler
Biomedicines.2023; 11(5): 1302. CrossRef
Role of adipokines in sarcopenia
Wenhao Lu, Wenjie Feng, Jieyu Lai, Dongliang Yuan, Wenfeng Xiao, Yusheng Li
Chinese Medical Journal.2023;[Epub] CrossRef
Resistin, TNF-α, and microRNA 124-3p expressions in peripheral blood mononuclear cells are associated with diabetic nephropathy
Amin Monjezi, Azam Khedri, Mehrnoosh Zakerkish, Ghorban Mohammadzadeh
International Journal of Diabetes in Developing Countries.2022; 42(1): 62. CrossRef
Resistin in Urine and Breast Milk: Relation to Type of Feeding and Anthropometry at 1-Month
Irena Santosa, Hiromichi Shoji, Kentaro Awata, Yoshiteru Arai, Hiroki Suganuma, Toshiaki Shimizu
Pediatric Reports.2022; 14(1): 86. CrossRef
High Serum Levels of Resistin is Associated With Acute Cerebral Infarction
Kee Ook Lee, Kyung-Yul Lee, Cheol-Young Lee, Ji Hoon Kim, Jaeku Kang, Hoi Young Lee, Sang-Jun Na, Seung-Hun Oh, Ji Hoe Heo
The Neurologist.2022; 27(2): 41. CrossRef
Resistin production does not affect outcomes in a mouse model of acute surgical sepsis
Anthony S. Bonavia, Zissis C. Chroneos, Victor Ruiz-Velasco, Charles H. Lang, Partha Mukhopadhyay
PLOS ONE.2022; 17(3): e0265241. CrossRef
Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population
Iman Akhlaghipour, Amir Reza Bina, Mohammad Reza Mogharrabi, Ali Fanoodi, Amir Reza Ebrahimian, Soroush Khojasteh Kaffash, Atefeh Babazadeh Baghan, Mohammad Erfan Khorashadizadeh, Negin Taghehchian, Meysam Moghbeli
Human Genomics.2022;[Epub] CrossRef
Synergistic Effects of Weighted Genetic Risk Scores and Resistin and sST2 Levels on the Prognostication of Long-Term Outcomes in Patients with Coronary Artery Disease
Hsin-Hua Chou, Lung-An Hsu, Jyh-Ming Jimmy Juang, Fu-Tien Chiang, Ming-Sheng Teng, Semon Wu, Yu-Lin Ko
International Journal of Molecular Sciences.2022; 23(8): 4292. CrossRef
Hypoxia Increases the Potential for Neutrophil-mediated Endothelial Damage in Chronic Obstructive Pulmonary Disease
Katharine M. Lodge, Arlette Vassallo, Bin Liu, Merete Long, Zhen Tong, Paul R. Newby, Danya Agha-Jaffar, Koralia Paschalaki, Clara E. Green, Kylie B. R. Belchamber, Victoria C. Ridger, Robert A. Stockley, Elizabeth Sapey, Charlotte Summers, Andrew S. Cowb
American Journal of Respiratory and Critical Care Medicine.2022; 205(8): 903. CrossRef
The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer
Klaudia Parafiniuk, Wiktoria Skiba, Anna Pawłowska, Dorota Suszczyk, Aleksandra Maciejczyk, Iwona Wertel
Biomedicines.2022; 10(4): 920. CrossRef
Resistin Modulates Low-Density Lipoprotein Cholesterol Uptake in Human Placental Explants via PCSK9
Sonia Nava-Salazar, Arturo Flores-Pliego, Giovanni Pérez-Martínez, Sandra Parra-Hernández, America Vanoye-Carlo, Francisco Ibarguengoitia-Ochoa, Otilia Perichart-Perera, Enrique Reyes-Muñoz, Juan Mario Solis-Paredes, Salvador Espino y Sosa, Guadalupe Estr
Reproductive Sciences.2022; 29(11): 3242. CrossRef
Differential Association of Selected Adipocytokines, Adiponectin, Leptin, Resistin, Visfatin and Chemerin, with the Pathogenesis and Progression of Type 2 Diabetes Mellitus (T2DM) in the Asir Region of Saudi Arabia: A Case Control Study
Mohammad Muzaffar Mir, Rashid Mir, Mushabab Ayed Abdullah Alghamdi, Javed Iqbal Wani, Zia Ul Sabah, Mohammed Jeelani, Vijaya Marakala, Shahzada Khalid Sohail, Mohamed O’haj, Muffarah Hamid Alharthi, Mohannad Mohammad S. Alamri
Journal of Personalized Medicine.2022; 12(5): 735. CrossRef
Immune system and sarcopenia: Presented relationship and future perspective
Xuzhi Zhang, Hengzhen Li, Miao He, Jingyu Wang, Yuxiang Wu, Yusheng Li
Experimental Gerontology.2022; 164: 111823. CrossRef
Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes
Giuseppina Biondi, Nicola Marrano, Anna Borrelli, Martina Rella, Giuseppe Palma, Isabella Calderoni, Edoardo Siciliano, Pasquale Lops, Francesco Giorgino, Annalisa Natalicchio
International Journal of Molecular Sciences.2022; 23(10): 5522. CrossRef
Supplemental hydroxychloroquine therapy regulates adipokines in patients with systemic lupus erythematosus with stable disease
Risa Wakiya, Kiyo Ueeda, Hiromi Shimada, Shusaku Nakashima, Tomohiro Kameda, Nobuyuki Miyatake, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Mao Mizusaki, Rina Mino, Norimitsu Kadowaki, Hiroaki Dobashi
Clinical Rheumatology.2022; 41(11): 3345. CrossRef
Can soy isoflavones in combination with soy protein change serum concentration of adiponectin and resistin? A systematic review and meta‐analysis on randomized clinical trials
Mitra Hariri, Bahareh Amirkalali, Ensiyeh Mollanoroozy, Ali Gholami
Food Science & Nutrition.2022; 10(12): 4126. CrossRef
Adipokines: Deciphering the cardiovascular signature of adipose tissue
Joseph C. Galley, Shubhnita Singh, Wanessa M.C. Awata, Juliano V. Alves, Thiago Bruder-Nascimento
Biochemical Pharmacology.2022; 206: 115324. CrossRef
Evaluation of the Anti-Obesity Effect of Zeaxanthin and Exercise in HFD-Induced Obese Rats
Mona Al-thepyani, Salha Algarni, Hana Gashlan, Mohamed Elzubier, Lina Baz
Nutrients.2022; 14(23): 4944. CrossRef
Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial
Jan Mieszkowski, Andżelika Borkowska, Błażej Stankiewicz, Andrzej Kochanowicz, Bartłomiej Niespodziński, Marcin Surmiak, Tomasz Waldziński, Rafał Rola, Miroslav Petr, Jędrzej Antosiewicz
Nutrients.2021; 13(4): 1280. CrossRef
Resistin mitigates stemness and metabolic profile of human adipose-derived mesenchymal stem cells via insulin resistance
Komal Rawal, Kishan M. Purohit, Tushar P. Patel, Neeta Karont, Sarita Gupta
Cytokine.2021; 138: 155374. CrossRef
Resistin is co-secreted with adiponectin in white mouse adipocytes
Saliha Musovic, Man Mohan Shrestha, Ali M. Komai, Charlotta S. Olofsson
Biochemical and Biophysical Research Communications.2021; 534: 707. CrossRef
Resistin: Potential biomarker and therapeutic target in atherosclerosis
Li Zhou, Jun-Yi Li, Ping-Ping He, Xiao-Hua Yu, Chao-Ke Tang
Clinica Chimica Acta.2021; 512: 84. CrossRef
The circulating levels of CTRP1 and CTRP5 are associated with obesity indices and carotid intima-media thickness (cIMT) value in patients with type 2 diabetes: a preliminary study
Ziba Majidi, Solaleh Emamgholipour, Abolfazl Omidifar, Soheil Rahmani Fard, Hossein Poustchi, Mehrnoosh Shanaki
Diabetology & Metabolic Syndrome.2021;[Epub] CrossRef
Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation
Chin-Chuan Chen, Chen-Hsin Kuo, Yann-Lii Leu, Shu-Huei Wang
Pharmacological Research.2021; 164: 105291. CrossRef
A Focused Review of the Metabolic Side-Effects of Clozapine
Jessica W. Y. Yuen, David D. Kim, Ric M. Procyshyn, William J. Panenka, William G. Honer, Alasdair M. Barr
Frontiers in Endocrinology.2021;[Epub] CrossRef
A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer’s Disease, the 5XFAD Mouse
Antonio J. López-Gambero, Cristina Rosell-Valle, Dina Medina-Vera, Juan Antonio Navarro, Antonio Vargas, Patricia Rivera, Carlos Sanjuan, Fernando Rodríguez de Fonseca, Juan Suárez
International Journal of Molecular Sciences.2021; 22(10): 5365. CrossRef
Resistin in pregnancy: Analysis of determinants in pairs of umbilical cord blood and maternal serum
Anne Floeck, Nina Ferrari, Christine Joisten, Maria T. Puth, Brigitte Strizek, Ramona Dolscheid-Pommerich, Ulrich Gembruch, Waltraut M. Merz
Cytokine: X.2021; 3(2): 100052. CrossRef
Is resistin the master link between inflammation and inflammation-related chronic diseases?
Mohammed Taouis, Yacir Benomar
Molecular and Cellular Endocrinology.2021; 533: 111341. CrossRef
The dynamics of human bone marrow adipose tissue in response to feeding and fasting
Pouneh K. Fazeli, Miriam A. Bredella, Gisela Pachon-Peña, Wenxiu Zhao, Xun Zhang, Alexander T. Faje, Megi Resulaj, Sai P. Polineni, Tara M. Holmes, Hang Lee, Elizabeth K. O’Donnell, Ormond A. MacDougald, Mark C. Horowitz, Clifford J. Rosen, Anne Klibanski
JCI Insight.2021;[Epub] CrossRef
Resistin: A journey from metabolism to cancer
Ankita Deb, Bhavana Deshmukh, Pranay Ramteke, Firoz Khan Bhati, Manoj Kumar Bhat
Translational Oncology.2021; 14(10): 101178. CrossRef
Obesity is the basis of metabolic syndrome
A. F. Verbovoy, N. I. Verbovaya, Yu. A. Dolgikh
Obesity and metabolism.2021; 18(2): 142. CrossRef
Human Milk Metabolic Hormones: Analytical Methods and Current Understanding
Majed A. Suwaydi, Zoya Gridneva, Sharon L. Perrella, Mary E. Wlodek, Ching Tat Lai, Donna T. Geddes
International Journal of Molecular Sciences.2021; 22(16): 8708. CrossRef
Adipokines as Immune Cell Modulators in Multiple Sclerosis
Merel Rijnsburger, Niek Djuric, Inge A. Mulder, Helga E. de Vries
International Journal of Molecular Sciences.2021; 22(19): 10845. CrossRef
The Role of Adipokines in Cardiovascular Pathology
Valery Podzolkov , Anna Pokrovskaya, Ulyana Bazhanova , Tatyana Vargina , Svetlana Anatolievna Knyazeva , Daria Vanina
Open Access Macedonian Journal of Medical Sciences.2021; 9(F): 794. CrossRef
Measurement of Plasma Resistin Concentrations in Horses with Metabolic and Inflammatory Disorders
Beatriz Fuentes-Romero, Alberto Muñoz-Prieto, José J. Cerón, María Martín-Cuervo, Manuel Iglesias-García, Escolástico Aguilera-Tejero, Elisa Díez-Castro
Animals.2021; 12(1): 77. CrossRef
EFFECT OF DIET AND EXERCISE-INDUCE WEIGHT LOSS ON LEVEL OF RESISTIN IN PATIENT WITH OBESITY
О. I. Tokarenko, I. O. Andreieva, O. O. Tokarenko, M. M. Surmilo
Modern medical technology.2021; (4): 11. CrossRef
Alteration of gut microbiota affects expression of adiponectin and resistin through modifying DNA methylation in high-fat diet-induced obese mice
Hongyang Yao, Chaonan Fan, Yuanyuan Lu, Xiuqin Fan, Lulu Xia, Ping Li, Rui Wang, Tiantian Tang, Yuanyuan Wang, Kemin Qi
Genes & Nutrition.2020;[Epub] CrossRef
Resistin hormone in diabetic kidney disease and its relation to iron status and hepcidin
Zhian Sherzad Hayder, Zrar Saleem Kareem
International Urology and Nephrology.2020; 52(4): 749. CrossRef
Proteoglycans in Obesity-Associated Metabolic Dysfunction and Meta-Inflammation
Ariane R. Pessentheiner, G. Michelle Ducasa, Philip L. S. M. Gordts
Frontiers in Immunology.2020;[Epub] CrossRef
Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies
Andressa V. B. Nogueira, Marjan Nokhbehsaim, Sema Tekin, Rafael S. de Molon, Luis C. Spolidorio, Svenja Memmert, Anna Damanaki, Andreas Jäger, Sigrun Eick, James Deschner, Joni A. Cirelli
Mediators of Inflammation.2020; 2020: 1. CrossRef
Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease
Alan Chait, Laura J. den Hartigh
Frontiers in Cardiovascular Medicine.2020;[Epub] CrossRef
The possible role of endocrine dysfunction of adipose tissue in gestational diabetes mellitus
Patrik Šimják, Kateřina Anderlová, Anna Cinkajzlová, Antonín Pařízek, Michal Kršek, Martin Haluzík
Minerva Endocrinologica.2020;[Epub] CrossRef
High Plasma Resistin Levels Portend the Insulin Resistance-Associated Susceptibility to Early Cognitive Decline in Patients with Type 2 Diabetes Mellitus
Chenchen Wang, Xi Huang, Sai Tian, Rong Huang, Dan Guo, Hongyan Lin, Jiaqi Wang, Shaohua Wang
Journal of Alzheimer's Disease.2020; 75(3): 807. CrossRef
Resistin in metabolism, inflammation, and disease
Deeksha Tripathi, Sashi Kant, Saurabh Pandey, Nasreen Z. Ehtesham
The FEBS Journal.2020; 287(15): 3141. CrossRef
Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases
Lucia Recinella, Giustino Orlando, Claudio Ferrante, Annalisa Chiavaroli, Luigi Brunetti, Sheila Leone
Frontiers in Physiology.2020;[Epub] CrossRef
Correlation of CCL18 with Levels of Adi-pokines in the Sera of Patients with Myocardial Infarction in a 6-Month Period: Case Series
Atefeh GamarTalepoor, Ehsan Dowlatshahi, Mehrnoush Doroudchi
Iranian South Medical Journal.2020; 23(3): 222. CrossRef
The Mesentery, Systemic Inflammation, and Crohn’s Disease
Edgardo D Rivera, John Calvin Coffey, Dara Walsh, Eli D Ehrenpreis
Inflammatory Bowel Diseases.2019; 25(2): 226. CrossRef
Resistin and adenylyl cyclase-associated protein 1 (CAP1) regulate the expression of genes related to insulin resistance in BNL CL.2 mouse liver cells
Dimiter Avtanski, Karin Chen, Leonid Poretsky
Data in Brief.2019; 25: 104112. CrossRef
Proteomic profile of patients with atrial fibrillation undergoing cardiac surgery†
Ilias P Doulamis, George Samanidis, Aspasia Tzani, Asier Antoranz, Anastasios Gkogkos, Panagiotis Konstantopoulos, Vaia Pliaka, Angeliki Minia, Leonidas G Alexopoulos, Despina N Perrea, Konstantinos Perreas
Interactive CardioVascular and Thoracic Surgery.2019; 28(1): 94. CrossRef
Angiotensin-(1-7), Adipokines and Inflammation
Deborah de Farias Lelis, Daniela Fernanda de Freitas, Amanda Souto Machado, Thaísa Soares Crespo, Sérgio Henrique Sousa Santos
Metabolism.2019; 95: 36. CrossRef
New Insights into Adipokines as Potential Biomarkers for Type-2 Diabetes Mellitus
Marta Olivera-Santa Catalina, Pedro C. Redondo, Maria P. Granados, Carlos Cantonero, Jose Sanchez-Collado, Letizia Albarran, Jose J. Lopez
Current Medicinal Chemistry.2019; 26(22): 4119. CrossRef
Myokine–adipokine cross-talk: potential mechanisms for the association between plasma irisin and adipokines and cardiometabolic risk factors in Mexican children with obesity and the metabolic syndrome
Adrian M. Gonzalez-Gil, Mariana Peschard-Franco, Elena C. Castillo, Gustavo Gutierrez-DelBosque, Victor Treviño, Christian Silva-Platas, Luisa Perez-Villarreal, Gerardo Garcia-Rivas, Leticia Elizondo-Montemayor
Diabetology & Metabolic Syndrome.2019;[Epub] CrossRef
Early Life Exposures to Perfluoroalkyl Substances in Relation to Adipokine Hormone Levels at Birth and During Childhood
Colleen Shelly, Philippe Grandjean, Youssef Oulhote, Peter Plomgaard, Ruth Frikke-Schmidt, Flemming Nielsen, Denis Zmirou-Navier, Pal Weihe, Damaskini Valvi
The Journal of Clinical Endocrinology & Metabolism.2019; 104(11): 5338. CrossRef
Overweight and obesity in childhood: Dietary, biochemical, inflammatory and lifestyle risk factors
Samah R. Albataineh, Eman F. Badran, Reema F. Tayyem
Obesity Medicine.2019; 15: 100112. CrossRef
Effects of major adipokines and the −420 C > G resistin gene polymorphism on the long-term outcome of patients with acute ischemic stroke
Stella Bouziana, Konstantinos Tziomalos, Antonis Goulas, Timoleon-Achilleas Vyzantiadis, Maria Papadopoulou, Athanasia Panderi, Apostolos Ι. Ηatzitolios
International Journal of Neuroscience.2019; 129(10): 978. CrossRef
The Complex Interactions Between Obesity, Metabolism and the Brain
Romina María Uranga, Jeffrey Neil Keller
Frontiers in Neuroscience.2019;[Epub] CrossRef
Resistin: A reappraisal
E. Acquarone, F. Monacelli, R. Borghi, A. Nencioni, P. Odetti
Mechanisms of Ageing and Development.2019; 178: 46. CrossRef
Implications of resistin in type 2 diabetes mellitus and coronary artery disease: Impairing insulin function and inducing pro‐inflammatory cytokines
Melissa Emamalipour, Khaled Seidi, Ali Jahanban‐Esfahlan, Rana Jahanban‐Esfahlan
Journal of Cellular Physiology.2019; 234(12): 21758. CrossRef
Serum-based soluble markers differentiate psoriatic arthritis from osteoarthritis
Vinod Chandran, Fatima Abji, Anthony V Perruccio, Rajiv Gandhi, Suzanne Li, Richard J Cook, Dafna D Gladman
Annals of the Rheumatic Diseases.2019; 78(6): 796. CrossRef
Telmisartan prevents diet-induced obesity and preserves leptin transport across the blood-brain barrier in high-fat diet-fed mice
Franziska Schuster, Gianna Huber, Ines Stölting, Emily E. Wing, Kathrin Saar, Norbert Hübner, William A. Banks, Walter Raasch
Pflügers Archiv - European Journal of Physiology.2018; 470(11): 1673. CrossRef
Adipokines in human breast milk
Juergen Kratzsch, Yoon Ju Bae, Wieland Kiess
Best Practice & Research Clinical Endocrinology & Metabolism.2018; 32(1): 27. CrossRef
Addressing the Perfect Storm: Biomarkers in Obesity and Pathophysiology of Cardiometabolic Risk
Krasimira Aleksandrova, Dariush Mozaffarian, Tobias Pischon
Clinical Chemistry.2018; 64(1): 142. CrossRef
Adipocytokine Involvement in Innate Immune Mechanisms
Paulina Żelechowska, Elżbieta Kozłowska, Joanna Pastwińska, Justyna Agier, Ewa Brzezińska-Błaszczyk
Journal of Interferon & Cytokine Research.2018; 38(12): 527. CrossRef
The effect of a garlic supplement on the pro-inflammatory adipocytokines, resistin and tumor necrosis factor-alpha, and on pain severity, in overweight or obese women with knee osteoarthritis
Sahar Dehghani, Elham Alipoor, Ahmad Salimzadeh, Mehdi Yaseri, Mostafa Hosseini, Christine Feinle-Bisset, Mohammad Javad Hosseinzadeh-Attar
Phytomedicine.2018; 48: 70. CrossRef
Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword
Xiao-Yan Qi, Shun-Lin Qu, Wen-Hao Xiong, Oren Rom, Lin Chang, Zhi-Sheng Jiang
Cardiovascular Diabetology.2018;[Epub] CrossRef
Usefulness of the Adipokines as Biomarkers of Ischemic Cardiac Dysfunction
Larisa-Diana Mocan Hognogi, Cerasela-Mihaela Goidescu, Anca-Daniela Farcaş
Disease Markers.2018; 2018: 1. CrossRef
Circulating fibroblast growth factor 21 in patients with liver cirrhosis
Sabrina Krautbauer, Lisa Rein-Fischboeck, Elisabeth M Haberl, Rebekka Pohl, Reiner Wiest, Christa Buechler
Clinical and Experimental Medicine.2018; 18(1): 63. CrossRef
Association of Cord Blood Resistin with Neonatal Birth Weight and Gestational Age
Shahnaz Pourarian, Saeed Fotouhikia, Forough Saki
Journal of Comprehensive Pediatrics.2018;[Epub] CrossRef
Major Adipokines and the −420C>G Resistin Gene Polymorphism as Predictors of Acute Ischemic Stroke Severity and In-Hospital Outcome
Styliani D. Bouziana, Konstantinos Tziomalos, Antonios Goulas, Timoleon-Achilleas Vyzantiadis, Athanasia Panderi, Apostolos Ι. Ηatzitolios
Journal of Stroke and Cerebrovascular Diseases.2018; 27(4): 963. CrossRef
Resistin and NGAL are associated with inflammatory response, endothelial activation and clinical outcomes in sepsis
Stephen P. J. Macdonald, Erika Bosio, Claire Neil, Glenn Arendts, Sally Burrows, Lisa Smart, Simon G. A. Brown, Daniel M. Fatovich
Inflammation Research.2017; 66(7): 611. CrossRef
Reference values for fasting serum resistin in healthy children and adolescents
Ulrik Lausten-Thomsen, Michael Christiansen, Paula Louise Hedley, Tenna Ruest Haarmark Nielsen, Cilius Esmann Fonvig, Oluf Pedersen, Torben Hansen, Jens-Christian Holm
Clinica Chimica Acta.2017; 469: 161. CrossRef
Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis
Alexander Kalinkovich, Gregory Livshits
Ageing Research Reviews.2017; 35: 200. CrossRef
Is There Any Relationship between Plasma 25-Hydroxyvitamin D3, Adipokine Profiles and Excessive Body Weight in Type 2 Diabetic Patients?
Joanna Kocot, Piotr Dziemidok, Małgorzata Kiełczykowska, Jacek Kurzepa, Grzegorz Szcześniak, Irena Musik
International Journal of Environmental Research and Public Health.2017; 15(1): 19. CrossRef
Exogenous Adipokine Peptide Resistin Protects Against Focal Cerebral Ischemia/Reperfusion Injury in Mice
Jiangtao Zhu, Di Wu, Chenyu Zhao, Man Luo, Ronald C. Hamdy, Balvin H. L. Chua, Xingshun Xu, Zhigang Miao
Neurochemical Research.2017; 42(10): 2949. CrossRef
Adipokines in Liver Cirrhosis
Christa Buechler, Elisabeth Haberl, Lisa Rein-Fischboeck, Charalampos Aslanidis
International Journal of Molecular Sciences.2017; 18(7): 1392. CrossRef
The role of sex steroids in white adipose tissue adipocyte function
A E Newell-Fugate
Reproduction.2017; 153(4): R133. CrossRef
Odanacatib Inhibits Resistin-induced Cardiomyocyte Hypertrophy Through the Inactivation of ERK Signaling Pathway
Xian Zheng, Guanchang Cheng, Jianwei Luo, Qunhui Ye, Yongzhi Deng, Lin Wu
International Journal of Pharmacology.2017; 13(2): 212. CrossRef
Linking resistin, inflammation, and cardiometabolic diseases
Hyeong Kyu Park, Mi Kyung Kwak, Hye Jeong Kim, Rexford S. Ahima
The Korean Journal of Internal Medicine.2017; 32(2): 239. CrossRef
Translating the biology of adipokines in atherosclerosis and cardiovascular diseases: Gaps and open questions
M. Ruscica, A. Baragetti, A.L. Catapano, G.D. Norata
Nutrition, Metabolism and Cardiovascular Diseases.2017; 27(5): 379. CrossRef
Differences in Mean Levels of Maternal Resistin Serum between Early Onset Preeclampsia (EOPE) and Late Onset Preeclampsia (LOPE)
Yusrawati ., P. Alfajra, R. Machmud
Research Journal of Obstetrics and Gynecology.2016; 10(1): 1. CrossRef
Secret talk between adipose tissue and central nervous system via secreted factors—an emerging frontier in the neurodegenerative research
Avinash Parimisetty, Anne-Claire Dorsemans, Rana Awada, Palaniyandi Ravanan, Nicolas Diotel, Christian Lefebvre d’Hellencourt
Journal of Neuroinflammation.2016;[Epub] CrossRef
The role of adipokines in ischemic stroke risk stratification
Styliani Bouziana, Konstantinos Tziomalos, Antonios Goulas, Apostolos Ι Ηatzitolios
International Journal of Stroke.2016; 11(4): 389. CrossRef
The endocrine function of human placenta: an overview
Mariana A. Costa
Reproductive BioMedicine Online.2016; 32(1): 14. CrossRef
Ursolic acid plays a protective role in obesity-induced cardiovascular diseases
Yu-Ting Lin, Ya-Mei Yu, Weng-Cheng Chang, Su-Yin Chiang, Hsu-Chin Chan, Ming-Fen Lee
Canadian Journal of Physiology and Pharmacology.2016; 94(6): 627. CrossRef
Determinants of body weight regulation in humans
Milene Moehlecke, Luis Henrique Canani, Lucas Oliveira Junqueira e Silva, Manoel Roberto Maciel Trindade, Rogerio Friedman, Cristiane Bauermann Leitão
Archives of Endocrinology and Metabolism.2016; 60(2): 152. CrossRef
Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats
Tsung-Ming Lee, Wei-Ting Chen, Nen-Chung Chang
Bioscience Reports.2016;[Epub] CrossRef
Les adipokines : état des lieux et nouveautés
J.-P. Bastard, C. Bastard, S. Fellahi, C. Vatier, J. Capeau, B. Fève
Obésité.2016; 11(3): 181. CrossRef
Factors that promote macrophage homing to adipose tissue in metabolic syndrome
Ishwarlal Jialal, Beverley Adams-Huet, Sridevi Devaraj
Journal of Diabetes and its Complications.2016; 30(8): 1434. CrossRef
Uncovering Factors Related to Pancreatic Beta-Cell Function
Aoife M. Curran, Miriam F. Ryan, Elaine Drummond, Eileen R. Gibney, Michael J. Gibney, Helen M. Roche, Lorraine Brennan, Nigel Irwin
PLOS ONE.2016; 11(8): e0161350. CrossRef
Resistin’s, obesity and insulin resistance: the continuing disconnect between rodents and humans
X. Huang, Z. Yang
Journal of Endocrinological Investigation.2016; 39(6): 607. CrossRef
Adipocytokines in renal transplant recipients
Kristof Nagy, Shankar Prasad Nagaraju, Connie M. Rhee, Zoltan Mathe, Miklos Z. Molnar
Clinical Kidney Journal.2016; 9(3): 359. CrossRef
Endocrine alterations from concentric vs. eccentric muscle actions: A brief review
Robert R. Kraemer, V. Daniel Castracane
Metabolism.2015; 64(2): 190. CrossRef
Non-traditional cytokines: How catecholamines and adipokines influence macrophages in immunity, metabolism and the central nervous system
Mark A. Barnes, Monica J. Carson, Meera G. Nair
Cytokine.2015; 72(2): 210. CrossRef
Local and serum levels of adipokines in patients with obesity after periodontal therapy: one‐year follow‐up
Tiago Eduardo Dias Gonçalves, Glaucia Santos Zimmermann, Luciene Cristina Figueiredo, Monique de Carvalho Souza, Daniele Ferreira da Cruz, Marta Ferreira Bastos, Hélio Doyle Pereira da Silva, Poliana Mendes Duarte
Journal of Clinical Periodontology.2015; 42(5): 431. CrossRef
Newborn Adipokines and Birth Outcomes
Edwina H. Yeung, Alexander C. McLain, Nancy Anderson, David Lawrence, Nansi S. Boghossian, Charlotte Druschel, Erin Bell
Paediatric and Perinatal Epidemiology.2015; 29(4): 317. CrossRef
The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats
Márta Sárközy, Gergő Szűcs, Márton Pipicz, Ágnes Zvara, Katalin Éder, Veronika Fekete, Csilla Szűcs, Judit Bárkányi, Csaba Csonka, László G. Puskás, Csaba Kónya, Péter Ferdinandy, Tamás Csont
Cardiovascular Diabetology.2015;[Epub] CrossRef
Diet-induced variability of the resistin gene (Retn) transcript level and methylation profile in rats
Joanna Nowacka-Woszuk, Ewa Pruszynska-Oszmalek, Maciej Szydlowski, Slawomir Sadkowski, Izabela Szczerbal
BMC Genetics.2015;[Epub] CrossRef
INFLUENCE OF RESISTIN ON THE COURSE OF ISCHEMIC HEART DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
A. T. Teplyakov, Sh. D. Akhmedov, T. Ye. Suslova, А. V. Andriyanova, A. V. Kuznetsova, N. V. Protopopova, V. V. Kalyuzhin, O. N. Nasanova
Bulletin of Siberian Medicine.2015; 14(5): 73. CrossRef
The Effects of a Single Developmentally Entrained Pulse of Testosterone in Female Neonatal Mice on Reproductive and Metabolic Functions in Adult Life
Hyeran Jang, Shalender Bhasin, Tyler Guarneri, Carlo Serra, Mary Schneider, Mi-Jeong Lee, Wen Guo, Susan K. Fried, Karol Pencina, Ravi Jasuja
Endocrinology.2015; 156(10): 3737. CrossRef
The Resin fromProtium heptaphyllumPrevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms
Karine Maria Martins Bezerra Carvalho, José Delano Barreto Marinho Filho, Tiago Sousa de Melo, Ana Jérsia Araújo, Josiane da Silva Quetz, Maria do Perpétuo Socorro Saldanha da Cunha, Karina Moura de Melo, Armenio Andre de Carvalho Almeida da Silva, Adrian
Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1. CrossRef
Evolution of the Vertebrate Resistin Gene Family
Qingda Hu, Huanran Tan, David M. Irwin, Marc Robinson-Rechavi
PLOS ONE.2015; 10(6): e0130188. CrossRef
Obesity, adipokines and neuroinflammation
Argel Aguilar-Valles, Wataru Inoue, Christoph Rummel, Giamal N. Luheshi
Neuropharmacology.2015; 96: 124. CrossRef
Adipokines at the crossroad between obesity and cardiovascular disease
Filippo Molica, Sandrine Morel, Brenda Kwak, Françoise Rohner-Jeanrenaud, Sabine Steffens
Thrombosis and Haemostasis.2015; 113(03): 553. CrossRef
Resistin – 420 C/G polymorphism and serum resistin level in Iranian patients with gestational diabetes mellitus
Mohammad Ali Takhshid, Zinab Zare
Journal of Diabetes & Metabolic Disorders.2015;[Epub] CrossRef
Ictal adipokines are associated with pain severity and treatment response in episodic migraine
Nu Cindy Chai, Bizu Gelaye, Gretchen E. Tietjen, Paul D. Dash, Barbara A. Gower, Linda W. White, Thomas N. Ward, Ann I. Scher, B. Lee Peterlin
Neurology.2015; 84(14): 1409. CrossRef
Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration
Lindsay J. Spielman, Jonathan P. Little, Andis Klegeris
Journal of Neuroimmunology.2014; 273(1-2): 8. CrossRef
Wild Blueberries (Vaccinium myrtillus) Alleviate Inflammation and Hypertension Associated with Developing Obesity in Mice Fed with a High-Fat Diet
Otto T. Mykkänen, Anne Huotari, Karl-Heinz Herzig, Thomas W. Dunlop, Hannu Mykkänen, Pirkka V. Kirjavainen, Michael Müller
PLoS ONE.2014; 9(12): e114790. CrossRef
Role of fat and adipokines in intestinal inflammation
LeaI Kredel, Arvind Batra, Britta Siegmund
Current Opinion in Gastroenterology.2014; 30(6): 559. CrossRef
13C metabolic flux analysis shows that resistin impairs the metabolic response to insulin in L6E9 myotubes
Shirley Guzmán, Silvia Marin, Anibal Miranda, Vitaly A Selivanov, Josep J Centelles, Romain Harmancey, Fatima Smih, Annie Turkieh, Yves Durocher, Antonio Zorzano, Philippe Rouet, Marta Cascante
BMC Systems Biology.2014;[Epub] CrossRef
Bee Pollen Improves Muscle Protein and Energy Metabolism in Malnourished Old Rats through Interfering with the Mtor Signaling Pathway and Mitochondrial Activity
Jérôme Salles, Nicolas Cardinault, Véronique Patrac, Alexandre Berry, Christophe Giraudet, Marie-Laure Collin, Audrey Chanet, Camille Tagliaferri, Philippe Denis, Corinne Pouyet, Yves Boirie, Stéphane Walrand
Nutrients.2014; 6(12): 5500. CrossRef

Editorial

Metformin and Cancer in Type 2 Diabetes: Hyeong Kyu Park; Diabetes Metab J. 2013;37(2):113-116. Published online April 16, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.2.113

3,274 View
40 Download
9 Crossref

PDF PubReader

Citations

Citations to this article as recorded by

Diabetes, metformin and cancer risk in myotonic dystrophy type I
Rotana Alsaggaf, Ruth M. Pfeiffer, Youjin Wang, Diane Marie M. St. George, Min Zhan, Kathryn R. Wagner, Sania Amr, Mark H. Greene, Shahinaz M. Gadalla
International Journal of Cancer.2020; 147(3): 785. CrossRef
Metformin, Asian ethnicity and risk of prostate cancer in type 2 diabetes: a systematic review and meta-analysis
Christopher B. Chen, Maxim Eskin, Dean T. Eurich, Sumit R. Majumdar, Jeffrey A. Johnson
BMC Cancer.2018;[Epub] CrossRef
Metformin and aspirin treatment could lead to an improved survival rate for Type 2 diabetic patients with stage II and III colorectal adenocarcinoma relative to non-diabetic patients
Ariella De Monte, Davide Brunetti, Luigi Cattin, Francesca Lavanda, Erica Naibo, Maria Malagoli, Giorgio Stanta, Serena Bonin
Molecular and Clinical Oncology.2018;[Epub] CrossRef
The association between metabolic health, obesity phenotype and the risk of breast cancer
Yong‐Moon Mark Park, Alexandra J. White, Hazel B. Nichols, Katie M. O'Brien, Clarice R. Weinberg, Dale P. Sandler
International Journal of Cancer.2017; 140(12): 2657. CrossRef
Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein
Feng J. Gao, Liang Shi, Timothy Hines, Sachin Hebbar, Kristi L. Neufeld, Deanna S. Smith, Erika Holzbaur
Molecular Biology of the Cell.2017; 28(5): 587. CrossRef
Metformin Promotes Apoptosis but Suppresses Autophagy in Glucose-Deprived H4IIE Hepatocellular Carcinoma Cells
Deok-Bae Park
Diabetes & Metabolism Journal.2015; 39(6): 518. CrossRef
Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
Young Mi Song, Yong-ho Lee, Ji-Won Kim, Dong-Sik Ham, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee, Byung-Wan Lee
Autophagy.2015; 11(1): 46. CrossRef
The anti-proliferative effect of metformin in triple-negative MDA-MB-231 breast cancer cells is highly dependent on glucose concentration: Implications for cancer therapy and prevention
Beshay N.M. Zordoky, Diana Bark, Carrie L. Soltys, Miranda M. Sung, Jason R.B. Dyck
Biochimica et Biophysica Acta (BBA) - General Subjects.2014; 1840(6): 1943. CrossRef
Nutrition and Healthy Ageing: Calorie Restriction or Polyphenol-Rich “MediterrAsian” Diet?
Kathrin Pallauf, Katrin Giller, Patricia Huebbe, Gerald Rimbach
Oxidative Medicine and Cellular Longevity.2013; 2013: 1. CrossRef

Case Reports

A Case of Multifocal Pyomyositis in Diabetes Mellitus.: Eun Seo Park, Joo Hyun Kim, Bo Yong Jung, Jae Ho Park, Ji Hun Ahn, Jun Young Lee, Soon Ho Hwang, Kyung Wook Lee, Jong Kyu Han, Ji O Mok, Yeo Joo Kim, Hyeong Kyu Park, Chul Hee Kim, Sang Jin Kim, Dong Won Byun, Kyo Il Suh, Myung Hi Yoo; Korean Diabetes J. 2006;30(2):140-144. Published online March 1, 2006; DOI: https://doi.org/10.4093/jkda.2006.30.2.140

2,260 View
20 Download

Abstract PDF: Pyomyositis is an acute bacterial infection of skeletal muscle, usually caused by Staphylococcus aureus. It is common in the tropics but rare in temperate climates. In temperature climate there are predisposing factors, such as diabetes, HIV infection, malignancy. The incidence of reported bacterial pyomyositis is increasing in recently, especially among immunocompromised persons such as HIV infection or diabetes mellitus. We experience multifocal pyomyositis in 49-year-old man with type 2 diabetes mellitus presented with drowsy mental state. Muscular USG and MRI finding shows multifocal abscess in thigh. Blood culture revealed Staphyloccus aureus. And patient received a intravenous broad-spectrum antibiotics, incision and drainage. He was successfully managed with drainage and antibiotics then discharge. Since diabetes or infection with HIV predisposes patients to bacterial infection, pyomyositis will occur more frequently. Increased awareness if the disease will improve management.

A Case of Acute Multifocal Bacterial Nephritis Associated with Diabetic Autonomic Neuropathy.: Eun Kyung Park, Jae Hak Lee, Ji Sung Yoon, Ji O Mok, Yeo Joo Kim, Hyeong Kyu Park, Chul Hee Kim, Sang Jin Kim, Dong Won Byun, Kyo Il Suh, Myung Hi Yoo; Korean Diabetes J. 2003;27(4):379-384. Published online August 1, 2003

1,212 View
19 Download

Abstract PDF: Acute multifocal bacterial nephritis is a severe form of acute renal infection in which a heavy leukocytic infiltrate occurs throughout the kidney. It is also an early phase of renal corticomedullary abscess. Clinically, patients have evidence of a severe urinary tract infection secondary to a gram-negative organism and there are frequently signs of sepsis. About half of the reported patients have been diabetics. Urinary tract infections are more common in diabetic women than in non-diabetic women. A variety of factors may contribute. The most important predisposing factor may be bladder dysfunction as a result of diabetic neuropathy and cystopathy. Diabetic cystopathy begins as decreased bladder sensation and decreased reflex detrusor activity caused by neuropathy affecting sympathetic and parasympathetic afferent fibers. Impaired bladder sensation results in bladder distention and increased residual urine volume. Long-term effects may eventually be vesicoureteral reflux and recurrent upper urinary tract infection. However, until now no diabetic patient with acute multifocal bacterial nephritis has been reported in Korea. Acute multifocal bacterial nephritis can be diagnosed by clinical manifestations and on radiologic grounds, including abdominal computed tomography showing multiple, wedge shaped, poorly defined areas of decreased contrast enhancement in multiple renal lobes. Therefore, we report the first Korean case of acute multifocal bacterial nephritis associated with diabetic autonomic neuropathy and review the literatures.

A Case of Invasive Aspergillosis of the Nasal Septum in a Patient with Diabetes Mellitus.: Tae Hoon Kim, Ji Sung Yoon, Ji O Mok, Yeo Joo Kim, Hyeong Kyu Park, Chul Hee Kim, Sang Jin Kim, Dong Won Byun, Kyo Il Suh, Myung Hi Yoo, Jang Mook Kim, Yoon Jung Kim; Korean Diabetes J. 2003;27(4):373-378. Published online August 1, 2003

1,355 View
19 Download

Abstract PDF: Invasive aspergillosis of the nasal cavity and paranasal sinuses is characterized by invasion and destruction of the bony sinus walls, the orbit, and other soft tissues of the face. It occurs particularly in patients with severe immune deficits, and less frequently in patients with diabetes mellitus. The therapeutic outcome of invasive aspergillosis is unsatisfactory. Mortality rates range from 50 to 80%, depending primarily on the underlying disease. In general, the prognosis depends on making a prompt diagnosis of infection and providing early treatment. However the diagnosis of invasive aspergillosis is difficult because there is no specific symptom, nor any rapid diagnostic method for confirmation. We report a case of a 64-year old woman with diabetes mellitus and invasive aspergillosis of the nasal septum. She was diagnosed by biopsy of the nasal septum and treated with systemic antifungal agent and surgical debridement. (Ed- paragraphs combined here) In conjunction with this case we review the previous literatures and suggest that prompt antifungal therapy with glycemic control is an important element in the treatment of invasive aspergillosis in a diabetic patient.

A Case of Endogenous Endophthalmitis in a Patient with Diabetic Retinopathy.: Chang Hee Han, Ji Sung Yoon, Ji O Mok, Yeo Joo Kim, Hyeong Kyu Park, Chul Hee Kim, Sang Jin Kim, Dong Won Byun, Kyo Il Suh, Myung Hi Yoo, Jun Sun Kim; Korean Diabetes J. 2003;27(4):367-372. Published online August 1, 2003

1,195 View
22 Download

Abstract PDF: Infectious endogenous endophthalmitis can occur by entrance of a pathogenic microorganism into the eye from various primary infection sites other than the eye. Although relatively rare, it results in visual loss frequently in spite of early diagnosis and treatment. It occurs in the process of systemic infection and its underlying conditions are diabetes, advanced liver disease, and immune suppressive state or drug abuse. We report a case of a 51-year old man with proliferative diabetic retinopathy and endogenous endophthalmitis caused by S. aureus from a skin infection. The ocular symptoms improved after systemic and intravitreal antibiotic therapy but visual loss could not be prevented. In conjunction with this case, we review the available literatures and stress the seriousness of this disease when concurrent in diabetic patients.

Original Articles

Impairment of Insulin Secretion by Fat Overload in Rat Pancreatic Islets and Effects of Antioxidants.: Chul Hee Kim, Chan Hee Kim, Hyeong Kyu Park, Kyo Il Suh, Ki Up Lee; Korean Diabetes J. 2002;26(5):347-356. Published online October 1, 2002

829 View
22 Download

Abstract PDF: BACKGROUND
It has recently been suggested that fat overload on pancreatic beta cells is responsible for the abnormal pattern of insulin secretion in type 2 diabetes mellitus. Antioxidant treatment was reported to preserve beta cell function in animal models of diabetes. This study was undertaken to examine the effects of various free fatty acids and triglyceride on insulin secretion in isolated rat pancreatic islets. In addition, we examined the effects of antioxidants. METHODS: Pancreatic islets of normal Sprague-Dawley rats were isolated by intraductal injection of collagenase and Ficoll-gradient centrifugation. The islets were treated with palmitat0e (C16:0), oleate (C18:1), linoleate (C18:2), and triglyceride emulsions (intralipid) for 72hours. Basal and glucose-stimulated insulin secretions were measured. The effects of the antioxidants, vitamin E, alpha-lipoic acid, and N-acetyl cysteine, were examined on the fat-induced change of insulin secretion. RESULTS: All of the free fatty acids and the triglyceride increased the basal insulin secretion. In contrast, insulin secretion stimulated by 27 mM glucose was significantly decreased after the treatment with free fatty acids or triglycerides. The antioxidant could not prevent the fat-induced inhibition of insulin secretion. CONCLUSION: These results show that various free fatty acids and triglyceride commonly cause defects in insulin secretion. However, we could not confirm the the hypothesis that increased oxidative stress may be involved in the pathogenesis of insulin secretory defect associated with fat overload.

Effects of Hydrogen Peroxide on Insulin Secretion in Rat Pancreatic Islets.: Chul Hee Kim, Chan Hee Kim, Hyeong Kyu Park, Kyo Il Suh, Ki Up Lee; Korean Diabetes J. 2002;26(4):265-273. Published online August 1, 2002

1,905 View
61 Download

Abstract PDF: BACKGROUND
It has been hypothesized that reactive oxygen species (ROS) are involved in the progression of beta cell dysfunction in both type 1 and type 2 diabetes mellitus. On the other hand, recent evidence suggests that ROS might be an integral component of intracellular signaling. This study was undertaken to examine effects of hydrogen peroxide (H2O2) on insulin secretion by various secretagogues in isolated rat pancreatic islets. METHODS: Pancreatic islets from normal Sprague-Dawley rats were isolated by intraductal injection of collagenase and Ficoll-gradient centrifugation. Isolated islets were treated with H2O2 directly added to the culture media or continuously generated by glucose-glucose oxidase system for 24 hours. Insulin secretion stimulated by glucose, arginine, and KCl was measured by radioimmunoassay. RESULTS: Basal insulin secretion was increased after treatment with H2O2. Treatment with low concentration of H2O2 stimulated insulin secretion in response to 27 mM glucose. In contrast, insulin secretion stimulated by 27 mM glucose was significantly decreased after treatment with high concentrations of H2O2. Arginine- stimulated insulin secretion was increased by both low- and high concentrations of H2O2. Insulin secretion stimulated by KCl was not affected by treatment with H2O2. CONCLUSION: These results suggest that the effect of H2O2 is diverse according to its concentration and different insulin secretagogues. In particular, H2O2 has a dual action on glucose-induced insulin secretion. At low concentration, H2O2 can stimulate insulin secretion probably by acting on signaling pathway of stimulus- secretion coupling. In contrast, high concentrations of H2O2 impairs glucose- induced insulin secretion, probably by acting as an oxidative stress.

Effects of Antioxidants on Ethidium Bromide-induced Inhibition of Insulin Secretion in Rat Pancreatic Islets.: Chul Hee Kim, Chan Hee Kim, Hyeong Kyu Park, Kyo Il Suh, Ki Up Lee; Korean Diabetes J. 2002;26(3):179-187. Published online June 1, 2002

867 View
22 Download

Abstract PDF: BACKGROUND
It was recently shown that mitochondrial function in pancreatic beta-cells is essential in nutrient-stimulated insulin secretion. The inhibition of mitochondrial DNA (mtDNA) transcription by ethidium bromide (EtBr) has been reported to suppress glucose-induced insulin secretion in beta-cell lines. This study was undertaken to examine the effects of EtBr on insulin secretion in isolated normal rat pancreatic islets, and to see whether antioxidants could protect the beta-cell function against the EtBr-induced impairment. METHODS: Pancreatic islets of normal Sprague-Dawley rats were isolated by intraductal injection of collagenase followed by Ficoll-gradient centrifugation. Isolated islets were treated with 0.2 +/- 2.0 microgram/mL of EtBr for 2 to 6 days, and the glucose-stimulated insulin secretion measured. The effects of the antioxidant, vitamin E and alpha-lipoic acid, on the EtBr-induced inhibition of insulin secretion were also examined. RESULTS: EtBr inhibited the basal and glucose-stimulated insulin secretion in normal rat pancreatic islets in a dose- and time-dependent manner. Vitamin E and alpha-lipoic acid prevented the EtBr-induced inhibition of insulin secretion. CONCLUSION: Our results show that antioxidant can protect normal rat pancreatic islets from the EtBr-induced inhibition of insulin secretion. This suggests that oxidative stress is involved in the pathogenesis of the insulin secretory defect associated with mitochondrial dysfunction.

Pancreatic beta-cell Function and Development in Male Offspring of Protein-Malnourished Rats.: Hyeong Kyu Park, Cheng Ji Jin, Do Joon Park, Chan Soo Shin, Kyong Soo Park, Seong Yeon Kim, Hong Kyu Lee; Korean Diabetes J. 2002;26(1):21-30. Published online February 1, 2002

1,087 View
20 Download

Abstract PDF: BACKGROUND
Nutritional deprivation of the fetus and infant may be associated with susceptibility to impaired glucose tolerance or type 2 diabetes in adult life. This association has been interpreted as a long-term effects of nutritional factors that reduce fetal growth and impair the development of tissues that regulate glucose metabolism. This study aimed to investigate the effect of protein malnutrition in a fetus and early life on the pancreatic beta-cell function and development. METHODS: Sprague-Dawley rats were fed a low-protein (8% casein) diet during pregnancy and lactation. Their male offspring were weaned onto either a control (18% casein) diet (recuperated group, R) or a low-protein diet (low-protein group, LP). The offspring of the rats fed control diet were weaned onto control diet (control group, C). Glucose tolerance tests and morphometry of the pancreas were performed to evaluate the pancreatic beta-cell function and development at the 25th week of age. RESULTS: Offspring of the protein-malnourished rats had a significantly lower body weights than the controls. The R and LP showed no major impairment in glucose tolerance, but the plasma insulin concentrations in the R (0.24+/-.03 nmol/L) and LP (0.28+/-.02 nmol/L) groups were lower at 20 min during IVGTT than the C (0.43+/-.05 nmol/L) groups. The areas under the curve for insulin (AUC insulin) during IVGTT were significantly lower in R and LP (0.39+/-.03 nmol/L/min, 0.43+/-.02 nmol/L/min) groups than the C (0.54+/-.03 nmol/L/min) group. In particular, the rats with fetal protein malnutrition showed severe impairment in late-phase insulin secretion to a glucose load. Both the pancreas weight and the proportion of the pancreas weight to the body weight were significantly lower in the R and LP groups than the C group. The proportion of beta-cells to pancreatic cells was lower in the LP (0.91+/-.14%) group than the C (2.19+/-.23%) and R (1.79+/-.25%) group. The relative beta-cell mass was significantly lower in the LP (by 62%) group that the C group. CONCLUSION: Rats with fetal protein malnutrition showed persistently impaired pancreatic beta-cell development and reduced insulin secretion capacity. These findings suggest that in utero protein malnutrition can contribute to the development of type 2 diabetes in adult life along with other deleterious environmental or genetic conditions.

Polymorphism of the Uncoupling Protein 1 (UCP-1) Gene and Fatty Acid Binding Protein 2 (FABP2) Gene in Korean Type 2 Diabetic Patients.: Sun Gyu Kim, Chul Hee Kim, Seog Ki Yun, Yeo Il Yun, Yong Hyun Kim, Il Song Nam, Ju Young Lee, Ji O Mok, Hyeong Kyu Park, Young Sun Kim, Dong Won Byun, Kyo Il Suh, Myung Hi Yoo; Korean Diabetes J. 2001;25(4):262-272. Published online August 1, 2001

1,227 View
18 Download

Abstract PDF: BACKGROUND
It is well known that genetic component plays an important role in developing obesity and type 2 diabetes mellitus. A number of candidate genes have been suggested, but the major gene determining the development of obesity and type 2 diabetes has not yet been uncovered. Previous studies suggest that polymorphisms of the intestinal fatty acid binding protein (FABP2) and uncoupling protein 1 (UCP-1) gene were related with obesity and/or insulin resistance in several populations. METHODS: We examined 76 type 2 diabetic patients (aged 44+/-6 years) and 96 healthy controls (aged 25+/-3 years). Ala54Thr polymorphism of the FABP2 gene and A to G polymorphism (-3826) of the UCP-1 gene were determined by polymerase chain reaction and restriction fragment length polymorphism method. RESULTS: The Thr54 allele of the FABP2 gene was found with a frequency of 0.33 in nondiabetic controls and 0.36 in type 2 diabetic patients. The genotype frequency of the Ala54Thr polymorphism was similar in nondiabetic and diabetic subjects ( 2=0.87, P=0.64). The -3826 G allele of UCP-1 gene was found with a frequency of 0.51 in nondiabetic controls, and 0.46 in type 2 diabetic patients. The genotype frequency of the -3826 A to G polymorphism was also similar in nondiabetic and diabetic subjects ( 2=1.46, p=0.46). When the subjects of each groups were subdivided into nonobese and obese group by BMI of 25 kg/m2, there was no significant difference in genotype frequencies of the UCP-1 and FABP2 gene polymorphisms. CONCLUSION: These results suggest that either the Ala54Thr polymorphism of the FABP2 gene or the A to G polymorphism (-3826) of UCP-1 gene do not play a major role in developing type 2 diabetes mellitus or obesity in Korean.

First
Prev
Page of 2
Next
Last

Search