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Original Article
The Association of Serum Cystatin C with Glycosylated Hemoglobin in Korean Adults
Eun Hee Sim, Hye Won Lee, Hyun Ju Choi, Dong Wook Jeong, Seok Man Son, Yang Ho Kang
Diabetes Metab J. 2016;40(1):62-69.   Published online November 27, 2015
DOI: https://doi.org/10.4093/dmj.2016.40.1.62
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  • 6 Web of Science
  • 7 Crossref
AbstractAbstract PDFPubReader   
Background

Cystatin C has been known to be associated not only with early renal impairment but also with the incidence of diabetic conditions (prediabetes plus diabetes). However, it is not clear whether cystatin C levels are associated with the prevalence of diabetic conditions in Asian populations. We evaluated this association using glycosylated hemoglobin (HbA1c) levels as the definition of diabetes in Korean adults.

Methods

We analyzed data from 1,559 Korean adults (937 men and 622 women) with available serum cystatin C and HbA1c values.

Results

The serum cystatin C levels in subjects with prediabetes and diabetes were significantly increased (0.91±0.14 mg/L in prediabetes and 0.91±0.17 mg/L in diabetes vs. 0.88±0.13 mg/L in patients with normal glucose levels, P=0.001). At increasing cystatin C levels, the prevalence of subjects with prediabetes (30.2% vs. 14.6%, P<0.001) and those with diabetes (10.6% vs. 8.0%, P<0.001) significantly increased in the group with the highest cystatin C levels. The group with the highest cystatin C levels had a significantly increased odds ratio (OR) for the presence of diabetic conditions compared to the group with the lowest values in total subjects (OR, 2.35; 95% confidence interval [CI], 1.54 to 3.58; P<0.001) and in women (OR, 4.13; 95% CI, 1.97 to 8.65; P<0.001), though there was no significant increase after adjusting for multiple variables.

Conclusions

Higher levels of serum cystatin C are associated with an increased prevalence of diabetic conditions in Korean adults. Our findings may extend the positive association of cystatin C with diabetes incidence to an Asian population.

Citations

Citations to this article as recorded by  
  • Prognostic significance of serum cystatin C in acute brainstem infarctions patients
    H. Li, B. Zhang, Z. Huang, H. Wu, B. Qin, L. Zhou, Z. Lu, F. Qin
    Revue Neurologique.2024;[Epub]     CrossRef
  • Cardiovascular risk assessment in prediabetic patients in a hypertensive population: The role of cystatin C
    Rafael Garcia-Carretero, Luis Vigil-Medina, Inmaculada Mora-Jimenez, Cristina Soguero-Ruiz, Rebeca Goya-Esteban, Javier Ramos-Lopez, Oscar Barquero-Perez
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2018; 12(5): 625.     CrossRef
  • Characteristics of Dapagliflozin Responders: A Longitudinal, Prospective, Nationwide Dapagliflozin Surveillance Study in Korea
    Eugene Han, Ari Kim, Sung Jae Lee, Je-Yon Kim, Jae Hyeon Kim, Woo Je Lee, Byung-Wan Lee
    Diabetes Therapy.2018; 9(4): 1689.     CrossRef
  • Cystatin C as a Predictor for Diabetes according to Glycosylated Hemoglobin Levels in Korean Patients
    Eon Ju Jeon, Ji Hyun Lee
    Diabetes & Metabolism Journal.2016; 40(1): 32.     CrossRef
  • Prevalence of Reduced Kidney Function by Estimated Glomerular Filtration Rate Using an Equation Based on Creatinine and Cystatin C in Metabolic Syndrome and Its Components in Korean Adults
    Yang Ho Kang, Dong Wook Jeong, Seok Man Son
    Endocrinology and Metabolism.2016; 31(3): 446.     CrossRef
  • Letter: The Association of Serum Cystatin C with Glycosylated Hemoglobin in Korean Adults (Diabetes Metab J 2016;40:62-9)
    Kyung-Soo Kim
    Diabetes & Metabolism Journal.2016; 40(2): 171.     CrossRef
  • Response: The Association of Serum Cystatin C with Glycosylated Hemoglobin in Korean Adults (Diabetes Metab J 2016;40:62-9)
    Yang Ho Kang
    Diabetes & Metabolism Journal.2016; 40(2): 173.     CrossRef

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