Reduction of beta cell function and a beta cell mass is observed in both type 1 and type 2 diabetes. Therefore, restoration of this deficiency might be a therapeutic option for treatment of diabetes. Islet transplantation has benefits, such as reduced incidence of hypoglycemia and achievement of insulin independence. However, the major drawback is an insufficient supply of islet donors. Transplantation of cells differentiated in vitro or in vivo regeneration of insulin-producing cells are possible approaches for beta cell/islet regenerative therapy. Embryonic and adult stem cells, pancreatic ductal progenitor cells, acinar cells, and other endocrine cells have been shown to differentiate into pancreatic beta cells. Formation of fully functional beta cells and the safety of these cells are critical issues for successful clinical application.

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• The efficiency of stem cell differentiation into functional beta cells for treating insulin-requiring diabetes: Recent advances and current challenges
  Yunfei Luo, Peng Yu, Jianping Liu
  Endocrine.2024; 86(1): 1.     CrossRef
• Direct Reprogramming of Mice Skin Fibroblasts into Insulin-Producing CellsIn Vitro
  Israa S. Salman, Ahmed Majeed Al-Shammari, Mukhtar Khamis Haba
  Cellular Reprogramming.2022; 24(5): 271.     CrossRef
• Effects of β-like cell autotransplantation through hepatic arterial intervention on diabetic dogs
  Yongxu Mu, Zhiming Hao, Junfeng He, Ruiqiang Yan, Haiyan Liu, Lei Zhang, Heming Liu, Xiaoyan Hu, Qiming Li
  Artificial Cells, Nanomedicine, and Biotechnology.2016; 44(5): 1333.     CrossRef
• Meeting the Need for Regenerative Therapies I: Target-Based Incidence and Its Relationship to U.S. Spending, Productivity, and Innovation
  Nancy Parenteau, Janet Hardin-Young, William Shannon, Patrick Cantini, Alan Russell
  Tissue Engineering Part B: Reviews.2012; 18(2): 139.     CrossRef
• Glucose-stimulated insulin secretion of various mesenchymal stem cells after insulin-producing cell differentiation
  Su-Jung Kim, Yong-Soo Choi, Eun-Sun Ko, Sang-Min Lim, Chang-Woo Lee, Dong-Il Kim
  Journal of Bioscience and Bioengineering.2012; 113(6): 771.     CrossRef