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Diabetes Metab J : Diabetes & Metabolism Journal



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1 "Haleh Sadrzadeh-Yeganeh"
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Original Article
APO A2 -265T/C Polymorphism Is Associated with Increased Inflammatory Responses in Patients with Type 2 Diabetes Mellitus
Fariba Koohdani, Haleh Sadrzadeh-Yeganeh, Mahmoud Djalali, Mohammadreza Eshraghian, Elham Zamani, Gity Sotoudeh, Mohammad-Ali Mansournia, Laleh Keramat
Diabetes Metab J. 2016;40(3):222-229.   Published online June 20, 2016
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  • 12 Web of Science
  • 11 Crossref
AbstractAbstract PDFPubReader   

Apolipoprotein A2 (APO A2) is the second most abundant structural apolipoprotein in high density lipoprotein. Several studies have examined the possible effect of APO A2 on atherosclerosis incidence. Due to the role of inflammation in atherosclerosis, we aimed to determine the relationship between APO A2 -265T/C polymorphism and inflammation as a risk factor in type 2 diabetes mellitus (T2DM) patients.


In total, 180 T2DM patients, with known APO A2 -265T/C polymorphism, were recruited for this comparative study and were grouped equally based on their genotypes. Dietary intakes, anthropometric parameters, lipid profile, and inflammatory markers (i.e., pentraxin 3 [PTX3], high-sensitivity C-reactive protein [hs-CRP], and interleukin 18) were measured. The data were analyzed using an independent t-test, a chi-square test, and the analysis of covariance.


After adjusting for confounding factors, in the entire study population and in the patients with or without obesity, the patients with the CC genotype showed higher hs-CRP (P=0.001, P=0.008, and P=0.01, respectively) and lower PTX3 (P=0.01, P=0.03, and P=0.04, respectively) in comparison with the T allele carriers. In the patients with the CC genotype, no significant differences were observed in the inflammatory markers between the obese or non-obese patients. However, regarding the T allele carriers, the plasma hs-CRP level was significantly higher in the obese patients compared to the non-obese patients (P=0.01).


In the T2DM patients, the CC genotype could be considered as a risk factor and the T allele as a protective agent against inflammation, which the latter effect might be impaired by obesity. Our results confirmed the anti-atherogenic effect of APO A2, though more studies are required to establish this effect.


Citations to this article as recorded by  
  • Proteomic Profiling of Extracellular Vesicles Isolated from Plasma and Peritoneal Exudate in Mice Induced by Crotalus scutulatus scutulatus Crude Venom and Its Purified Cysteine-Rich Secretory Protein (Css-CRiSP)
    Armando Reyes, Joseph D. Hatcher, Emelyn Salazar, Jacob Galan, Anton Iliuk, Elda E. Sanchez, Montamas Suntravat
    Toxins.2023; 15(7): 434.     CrossRef
  • ApoA2–256T > C polymorphism interacts with Healthy Eating Index, Dietary Quality Index-International and Dietary Phytochemical Index to affect biochemical markers among type 2 diabetic patients
    Zahra Esmaeily, Gity Sotoudeh, Masoumeh Rafiee, Fariba Koohdani
    British Journal of Nutrition.2022; 127(9): 1343.     CrossRef
  • Interaction between Apo A-II –265T > C polymorphism and dietary total antioxidant capacity on some oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus
    Banafsheh Jafari Azad, Mehdi Yaseri, Elnaz Daneshzad, Fariba Koohdani
    British Journal of Nutrition.2022; 128(1): 13.     CrossRef
  • Deletion allele of Apo B gene is associated with higher inflammation, oxidative stress and dyslipidemia in obese type 2 diabetic patients: an analytical cross-sectional study
    Nasim Mokhtary, Seyedeh Neda Mousavi, Gity Sotoudeh, Mostafa Qorbani, Maryam Dehghani, Fariba Koohdani
    BMC Endocrine Disorders.2022;[Epub]     CrossRef
  • Interaction between Apo A-II -265T>C polymorphism and dietary total antioxidant capacity on some anthropometric indices and serum lipid profile in patients with type 2 diabetes mellitus
    Banafsheh Jafari Azad, Mehdi Yaseri, Elnaz Daneshzad, Fariba Koohdani
    Journal of Nutritional Science.2021;[Epub]     CrossRef
  • A personalised diet study: The interaction between ApoA2 −265T > C polymorphism and dietary inflammatory index on oxidative and inflammatory markers and lipid profile in patients with type 2 diabetes mellitus: A cross‐sectional study
    Elmira Karimi, Pourya Tondkar, Gity Sotoudeh, Mostafa Qorbani, Masoumeh Rafiee, Fariba Koohdani
    International Journal of Clinical Practice.2021;[Epub]     CrossRef
  • Interaction between the dietary indices and PPAR‐γ Pro12Ala gene variants on cardiovascular risk factors in patients with type 2 diabetes mellitus
    Faezeh Abaj, Gity Sotoudeh, Elmira Karimi, Masoumeh Rafiee, Fariba Koohdani
    International Journal of Clinical Practice.2021;[Epub]     CrossRef
  • A Genetic Score of Predisposition to Low-Grade Inflammation Associated with Obesity May Contribute to Discern Population at Risk for Metabolic Syndrome
    Sebastià Galmés, Margalida Cifre, Andreu Palou, Paula Oliver, Francisca Serra
    Nutrients.2019; 11(2): 298.     CrossRef
  • Study of the relationship between APOA-II −265T>C polymorphism and HDL function in response to weight loss in overweight and obese type 2 diabetic patients
    Masoumeh Moradi, Maryam Mahmoudi, Ahmad Saedisomeolia, Mohammad Ali Mansournia, Roxana Zahirihashemi, Fariba Koohdani
    Clinical Nutrition.2018; 37(3): 965.     CrossRef
  • Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure
    Mu Yang, Yingye Liu, Jian Dai, Lin Li, Xin Ding, Zhe Xu, Masayuki Mori, Hiroki Miyahara, Jinko Sawashita, Keiichi Higuchi
    Scientific Reports.2018;[Epub]     CrossRef
  • Prenatal Exposure to Lipopolysaccharide Induces PTX3 Expression and Results in Obesity in Mouse Offspring
    Shugang Qin, Xin Chen, Meng Gao, Jianzhi Zhou, Xiaohui Li
    Inflammation.2017; 40(6): 1847.     CrossRef

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