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Original Article
- Cardiovascular Risk/Epidemiology
- Pre-existing Depression among Newly Diagnosed Dyslipidemia Patients and Cardiovascular Disease Risk
- Jihoon Andrew Kim, Seulggie Choi, Daein Choi, Sang Min Park
- Diabetes Metab J. 2020;44(2):307-315. Published online November 1, 2019
- DOI: https://doi.org/10.4093/dmj.2019.0002
- 6,078 View
- 100 Download
- 9 Web of Science
- 9 Crossref
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Abstract
PDF
Supplementary Material
PubReader Background Whether depression before diagnosis of dyslipidemia is associated with higher cardiovascular disease (CVD) risk among newly diagnosed dyslipidemia patients is yet unclear.
Methods The study population consisted of 72,235 newly diagnosed dyslipidemia patients during 2003 to 2012 from the National Health Insurance Service–Health Screening Cohort of South Korea. Newly diagnosed dyslipidemia patients were then detected for pre-existing depression within 3 years before dyslipidemia diagnosis. Starting from 2 years after the diagnosis date, patients were followed up for CVD until 2015. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for CVD were calculated by Cox proportional hazards regression.
Results Compared to dyslipidemia patients without depression, those with depression had higher risk for CVD (aHR, 1.24; 95% CI, 1.09 to 1.41). Similarly, pre-existing depression was associated with increased risk for stroke (aHR, 1.27; 95% CI, 1.06 to 1.53). The risk for CVD among depressed dyslipidemia patients for high (aHR, 1.42; 95% CI, 1.06 to 1.90), medium (aHR, 1.17; 95% CI, 0.91 to 1.52), and low (aHR, 1.25; 95% CI, 1.05 to 1.50) statin compliance patients tended to be increased compared to patients without pre-existing dyslipidemia. The risk-elevating effect of depression on CVD tended to be preserved regardless of subgroups of smoking, alcohol consumption, physical activity, and body mass index.
Conclusion Dyslipidemia patients with pre-existing depression had increased risk for CVD. Future studies that determine CVD risk after management of depression among dyslipidemia patients are needed.
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Citations
Citations to this article as recorded by
- An application of the Bayesian network model based on the EN-ESL-GA algorithm: Exploring the predictors of heart disease in middle-aged and elderly people in China
Wenlong Gao, Zhimei Zeng, Xiaojie Ma, Yongsong Ke, Minqian Zhi
Technology and Health Care.2024; : 1. CrossRef - Mediating effect of depression on the association between cardiovascular disease and the risk of all‐cause mortality: NHANES in 2005−2018
Xinxin Ma, Huan Zhang, Yuan Tian, Yaping Wang, Ling Liu, Lei Wang
Clinical Cardiology.2023; 46(11): 1380. CrossRef - Associations of sleep duration, daytime napping, and snoring with depression in rural China: a cross-sectional study
Xueyao Zhang, Guangxiao Li, Chuning Shi, Yingxian Sun
BMC Public Health.2023;[Epub] CrossRef - Association between socioeconomic inequality and the global prevalence of anxiety and depressive disorders: an ecological study
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General Psychiatry.2022; 35(3): e100735. CrossRef - Impact of Alexithymia on the Lipid Profile in Major Depressed Individuals
Camille Point, Benjamin Wacquier, Marjorie Dosogne, Mohammed Al Faker, Hadrien Willame, Gwenolé Loas, Matthieu Hein, Philip W. Wertz
Journal of Lipids.2022; 2022: 1. CrossRef - Association of Depression With Cardiovascular Diseases
Zain I Warriach, Sruti Patel, Fatima Khan, Gerardo F Ferrer
Cureus.2022;[Epub] CrossRef - Fenofibrate add-on to statin treatment is associated with low all-cause death and cardiovascular disease in the general population with high triglyceride levels
Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park
Metabolism.2022; 137: 155327. CrossRef - Dyslipidemia prevalence and trends among adult mental disorder inpatients in Beijing, 2005–2018: A longitudinal observational study
Fude Yang, Qiuyue Ma, Botao Ma, Wenzhan Jing, Jue Liu, Moning Guo, Juan Li, Zhiren Wang, Min Liu
Asian Journal of Psychiatry.2021; 57: 102583. CrossRef - Non-HDL cholesterol level and depression among Canadian elderly—a cross-sectional analysis of the baseline data from the CLSA
Jian Liu, Surim Son, Mike Giancaterino, Chris P. Verschoor, Miya Narushima, David Moher
FACETS.2020; 5(1): 1006. CrossRef
- An application of the Bayesian network model based on the EN-ESL-GA algorithm: Exploring the predictors of heart disease in middle-aged and elderly people in China
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