Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
1 "Dae-Jeong Koo"
Filter
Filter
Article category
Keywords
Publication year
Authors
Sulwon Lecture 2023
Metabolic Risk/Epidemiology
Article image
Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Clinical and Experimental Perspective
Inha Jung, Dae-Jeong Koo, Won-Young Lee
Diabetes Metab J. 2024;48(3):327-339.   Published online February 2, 2024
DOI: https://doi.org/10.4093/dmj.2023.0350
  • 17,602 View
  • 663 Download
  • 24 Web of Science
  • 28 Crossref
AbstractAbstract PDFPubReader   ePub   
It has been generally accepted that insulin resistance (IR) and reduced insulin secretory capacity are the basic pathogenesis of type 2 diabetes mellitus (T2DM). In addition to genetic factors, the persistence of systemic inflammation caused by obesity and the associated threat of lipotoxicity increase the risk of T2DM. In particular, the main cause of IR is obesity and subjects with T2DM have a higher body mass index (BMI) than normal subjects according to recent studies. The prevalence of T2DM with IR has increased with increasing BMI during the past three decades. According to recent studies, homeostatic model assessment of IR was increased compared to that of the 1990s. Rising prevalence of obesity in Korea have contributed to the development of IR, non-alcoholic fatty liver disease and T2DM and cutting this vicious cycle is important. My colleagues and I have investigated this pathogenic mechanism on this theme through clinical and experimental studies over 20 years and herein, I would like to summarize some of our studies with deep gratitude for receiving the prestigious 2023 Sulwon Award.

Citations

Citations to this article as recorded by  
  • Macrophage Plg-RKT expression promotes diet-induced obesity and metabolic dysfunction-associated steatotic liver disease
    Lindsey A. Miles, Hongdong Bai, Sagarika Chakrabarty, Nagyung Baik, Yuqing Zhang, Robert J. Parmer, Fahumiya Samad
    Journal of Thrombosis and Haemostasis.2026; 24(1): 241.     CrossRef
  • Hepatorenal vulnerability flagged by glomerular hyperfiltration in metabolic liver disease: a large health-screening cohort evidence
    Dae-Jeong Koo, Yun Tae Kim, Sun-Joon Moon, Hyemi Kwon, Se Eun Park, Sang Min Lee, Cheol-Young Park, Won-Young Lee, Sung Rae Cho, Eun-Jung Rhee
    Diabetology & Metabolic Syndrome.2026;[Epub]     CrossRef
  • Kudzu root-derived carbon dots modulate gut microbiota and metabolites for pan-organ targeted macrophage polarization in synergistic diabetes therapy
    Jianing Yi, Yuanyu Tang, Yilin Chen, Liang Chen, Dongxue Geng, Luyao Liu, Jie Yu, Lianhong Zou, Jie Zeng, Minhuan Lan, Wenjie Gao, Ming Gao
    Biomaterials.2026; 329: 123967.     CrossRef
  • γ-Glutamylcysteine restores glucolipotoxicity-induced islet β-cell apoptosis and dysfunction via inhibiting endoplasmic reticulum stress
    Jinyi Zhou, Yingying Shi, Lishuang Zhao, Rong Wang, Lan Luo, Zhimin Yin
    Toxicology and Applied Pharmacology.2025; 495: 117206.     CrossRef
  • Comparison of SPISE and METS-IR and Other Markers to Predict Insulin Resistance and Elevated Liver Transaminases in Children and Adolescents
    Kyungchul Song, Eunju Lee, Hye Sun Lee, Hana Lee, Ji-Won Lee, Hyun Wook Chae, Yu-Jin Kwon
    Diabetes & Metabolism Journal.2025; 49(2): 264.     CrossRef
  • Unraveling the Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic Interventions
    Mohammad Muzaffar Mir, Mohammed Jeelani, Muffarah Hamid Alharthi, Syeda Fatima Rizvi, Shahzada Khalid Sohail, Javed Iqbal Wani, Zia Ul Sabah, Waad Fuad BinAfif, Partha Nandi, Abdullah M. Alshahrani, Jaber Alfaifi, Adnan Jehangir, Rashid Mir
    International Journal of Molecular Sciences.2025; 26(6): 2770.     CrossRef
  • Investigating the Effects of Gossypetin on Liver Health in Diet-Induced Pre-Diabetic Male Sprague Dawley Rats
    Karishma Naidoo, Andile Khathi
    Molecules.2025; 30(8): 1834.     CrossRef
  • Associations between cardiometabolic indices and the onset of metabolic dysfunction-associated steatotic liver disease as well as its progression to liver fibrosis: a cohort study
    Ziping Song, Xinlei Miao, Shuang Liu, Manling Hu, Xiaoling Xie, Yuting Sun, Song Leng
    Cardiovascular Diabetology.2025;[Epub]     CrossRef
  • Hepatoprotective and Antiatherosclerotic Effects of Oleoylethanolamide-Based Dietary Supplement in Dietary-Induced Obesity in Mice
    Darya Ivashkevich, Arina Ponomarenko, Igor Manzhulo, Anastasia Egoraeva, Inessa Dyuizen
    Pathophysiology.2025; 32(2): 16.     CrossRef
  • Extracellular Vesicle-Mediated Network in the Pathogenesis of Obesity, Diabetes, Steatotic Liver Disease, and Cardiovascular Disease
    Joonyub Lee, Won Gun Choi, Marie Rhee, Seung-Hwan Lee
    Diabetes & Metabolism Journal.2025; 49(3): 348.     CrossRef
  • Association of cardiometabolic markers with hepatic steatosis and liver fibrosis in population without obesity and diabetes
    Zhixing Fan, Chaojun Yang, Xiaojing Zhao, Jing Zhang
    Scientific Reports.2025;[Epub]     CrossRef
  • The Triglyceride-Glucose Index and Risk of End-Stage Renal Disease across Different Durations of Type 2 Diabetes Mellitus: A Longitudinal Cohort Study
    Mi-sook Kim, Kyu-Na Lee, Jeongmin Lee, Jeongeun Kwak, Seung-Hwan Lee, Hyuk-Sang Kwon, Jing Hughes, Kyung-Do Han, Eun Young Lee
    Endocrinology and Metabolism.2025; 40(5): 718.     CrossRef
  • Tectoridin modulates intertwined molecular pathways in metabolic syndrome: insights from network pharmacology, molecular docking, and in vivo studies
    Ashwini Kumar Mishra, Pravat Kumar Sahoo, Rajesh Singh, Smita Jain
    Inflammopharmacology.2025; 33(9): 5545.     CrossRef
  • Triglyceride–Glucose-Based Anthropometric Indices for Predicting Incident Cardiovascular Disease: Relative Fat Mass (RFM) as a Robust Indicator
    Xinlei Chu, Haozhi Niu, Ning Wang, Yu Wang, Hongkai Xu, Huiying Wang, Liting Wu, Wei Li, Lei Han
    Nutrients.2025; 17(13): 2212.     CrossRef
  • Association of temporal MASLD with type 2 diabetes, cardiovascular disease and mortality
    Eugene Han, Kyung-Do Han, Yong-ho Lee, Kyung-Soo Kim, Sangmo Hong, Jung Hwan Park, Cheol-Young Park
    Cardiovascular Diabetology.2025;[Epub]     CrossRef
  • Associations between the effectiveness of sleeve gastrectomy and the composition and function of gut microbiome in obese rats
    Yifan Cao, Songhan Qin, Dandan Liu, Tao Zhang, Yin Wu, Ming Xie, Jiwei Wang
    Journal of Gastrointestinal Surgery.2025; 29(9): 102153.     CrossRef
  • Exercise Interventions for Metabolic Diseases: An Analysis of the Evolution of Aerobic Exercise Bibliometrics in the Field of Type 2 Diabetes Mellitus
    Yang Li, Amin Ullah, Shuhao Fang, Donglin Liu, Zhenwei Cui, Guangning Kou
    Healthcare.2025; 13(17): 2087.     CrossRef
  • Association Between Depression and Hepatic Steatosis According to Obese Status: The Korean National Health and Nutrition Examination Survey 2010–2019
    Young Sang Lyu, Youngmin Yoon, Jin Hwa Kim, Sang Yong Kim
    Medicina.2025; 61(9): 1711.     CrossRef
  • Serum Granulin Concentrations Are Elevated in Prediabetes and Newly Diagnosed Diabetes: A Cross-Sectional Study
    Yu-Hsuan Chou, Yuan Kao, Ka Chon Chan, Hsuan-Wen Chou, Yu-Cheng Liang, Hung-Tsung Wu, Horng-Yih Ou
    Journal of Clinical Medicine.2025; 14(18): 6566.     CrossRef
  • Recent Trends for Computational Enriched Diabetic Retinopathy Assessment: A Systematic Review
    Hrijuta Datta, Preity, Ashish Kumar Bhandari
    Archives of Computational Methods in Engineering.2025;[Epub]     CrossRef
  • Attention-based graph neural network framework for non-invasive CAP score prediction in fatty liver disease via body modeling
    Ghasem Sadeghi Bajestani, Fatemeh Makhloughi, Ayoub Basham, Ebrahim Evazi, Mahdiyeh Razm Pour, Roohallah Alizadehsani, Farkhondeh Razmpour
    Physical and Engineering Sciences in Medicine.2025;[Epub]     CrossRef
  • LGALS3BP Induces Insulin Resistance via TLR2-IKKα/β Pathway-Mediated IRS1 Serine Phosphorylation
    Minjeong Sung, Dae-Hwan Kim, Eun-Gene Sun, Jun-Eul Hwang, Sang-Hee Cho, Ik-Joo Chung, Hyun-Jeong Shim, Woo Kyun Bae
    Endocrinology and Metabolism.2025;[Epub]     CrossRef
  • Mechanistic Insights into N-Oleoylethanolamide-Mediated Hepatoprotection via PPAR-α
    Darya Ivashkevich, Arina Ponomarenko, Igor Manzhulo, Inessa Dyuizen
    BIOCELL.2025; 49(4): 607.     CrossRef
  • Clinical Implementation of Sustainable Functional Foods and Nutraceuticals in Metabolic Health: A Feasibility Study
    Francesca Scionti, Samantha Maurotti, Elisa Mazza, Angela Mirarchi, Raffaella Russo, Paola Doria, Rosario Mare, Giuseppe Marafioti, Yvelise Ferro, Tiziana Montalcini, Arturo Pujia
    Nutrients.2025; 17(24): 3858.     CrossRef
  • The association of multiple metabolic disorders with the severity of fasting blood glucose and hepatic steatosis in a Chinese population with MAFLD: a cross-sectional study of over 3000 participants
    Xue Qu, Shanshan Jin, Yuqing Shi, Weisong Zhang, Delong Cong, Yangyang Liu
    Scientific Reports.2025;[Epub]     CrossRef
  • Frequency and Association of Dyslipidemia with Clinical and Biochemical Parameters among Patients with Non-alcoholic Fatty Liver Disease
    Arslan Ahmad, Shazia Siddique, Amanullah Bhalli, Amina Umer, Umayma Asad, Muhammad Irfan Jamil
    Pakistan Journal of Health Sciences.2025; : 75.     CrossRef
  • Strategy for treating MAFLD: Electroacupuncture alleviates hepatic steatosis and fibrosis by enhancing AMPK mediated glycolipid metabolism and autophagy in T2DM rats
    Haoru Duan, Shanshan Song, Rui Li, Suqin Hu, Shuting Zhuang, Shaoyang liu, Xiaolu Li, Wei Gao
    Diabetology & Metabolic Syndrome.2024;[Epub]     CrossRef
  • Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Mellitus: A Review and Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association
    Jaehyun Bae, Eugene Han, Hye Won Lee, Cheol-Young Park, Choon Hee Chung, Dae Ho Lee, Eun-Hee Cho, Eun-Jung Rhee, Ji Hee Yu, Ji Hyun Park, Ji-Cheol Bae, Jung Hwan Park, Kyung Mook Choi, Kyung-Soo Kim, Mi Hae Seo, Minyoung Lee, Nan-Hee Kim, So Hun Kim, Won-
    Diabetes & Metabolism Journal.2024; 48(6): 1015.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP