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Korea's National Healthcare Program, the National Health Insurance Service (NHIS), a government-affiliated agency under the Korean Ministry of Health and Welfare, covers the entire Korean population. The NHIS supervises all medical services in Korea and establishes a systematic National Health Information database (DB). A health information DB system including all of the claims, medications, death information, and health check-ups, both in the general population and in patients with various diseases, is not common worldwide. On June 9, 2014, the NHIS signed a memorandum of understanding with the Korean Diabetes Association (KDA) to provide limited open access to its DB. By October 31, 2017, seven papers had been published through this collaborative research project. These studies were conducted to investigate the past and current status of type 2 diabetes mellitus and its complications and management in Korea. This review is a brief summary of the collaborative projects between the KDA and the NHIS over the last 3 years. According to the analysis, the national health check-up DB or claim DB were used, and the age category or study period were differentially applied.

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  Ho-Young Yhim, Juhyun Lee, Kyoung Ha Kim, Sang-A Kim, Ji Yun Lee, Hun-Gyu Hwang, Junshik Hong, Jeong-Ok Lee, Soo-Mee Bang
  Thrombosis Research.2023; 231: 50.     CrossRef
• Incidence, Morbidity, and Mortality of Achalasia: A Nationwide, Population-Based Cohort Study in South Korea
  Ga Hee Kim, Hyungchul Park, Kee Wook Jung, Min-Ju Kim, Ye-Jee Kim, Ji Min Lee, Bong Eun Lee, Yang Won Min, Jeong Hwan Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Hyun Jin Kim
  Gut and Liver.2023; 17(6): 894.     CrossRef
• Differential Impact of Obesity on the Risk of Diabetes Development in Two Age Groups: Analysis from the National Health Screening Program
  Tae Kyung Yoo, Kyung-Do Han, Yang-Hyun Kim, Ga Eun Nam, Sang Hyun Park, Eun-Jung Rhee, Won-Young Lee
  Diabetes & Metabolism Journal.2023; 47(6): 846.     CrossRef
• Association between preoperative modifiable lifestyle factors and mortality after cancer surgery: a population-based cohort study in South Korea
  Tak Kyu Oh, In-Ae Song
  Annals of Surgical Treatment and Research.2023; 105(4): 179.     CrossRef
• Classification of long-term clinical course of Parkinson’s disease using clustering algorithms on social support registry database
  Dougho Park, Su Yun Lee, Jong Hun Kim, Hyoung Seop Kim
  Journal of Big Data.2023;[Epub]     CrossRef
• Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study
  Hyungwoo Lee, Moo-Suk Park, Min Kyoung Kang, Tae-Jin Song
  Journal of Personalized Medicine.2023; 13(9): 1414.     CrossRef
• Association of physical activity with the risk of Parkinson's disease in depressive disorder: A nationwide longitudinal cohort study
  Ji hyun An, Kyung-do Han, Jin-Hyung Jung, Hong Jin Jeon
  Journal of Psychiatric Research.2023; 167: 93.     CrossRef
• Effect of changes in the hearing aid subsidy on the prevalence of hearing loss in South Korea
  Chul Young Yoon, Junhun Lee, Tae Hoon Kong, Young Joon Seo
  Frontiers in Neurology.2023;[Epub]     CrossRef
• Preoperative Body Mass Index, Waist Circumference, and Mortality After Major Cancer Surgery: A Nationwide Cohort Study in Korea
  Tak Kyu Oh, In-Ae Song
  Journal of Korean Medical Science.2023;[Epub]     CrossRef
• Characteristics and risk factors of suicide among people who attempted self-harm in South Korea: A longitudinal National Cohort Study in South Korea
  Hye Hyeon Kim, Jin Hyuk Lee, In Han Song, Yu Rang Park
  Psychiatry Research.2023; 330: 115613.     CrossRef
• Association Between Premature Menopause and Cardiovascular Diseases and All‐Cause Mortality in Korean Women
  Gyu Bae Lee, Ga Eun Nam, Wonsock Kim, Byoungduck Han, Kyung Hwan Cho, Seon Mee Kim, Youn Seon Choi, Do Hoon Kim, Yong‐Gyu Park, Jin‐Hyung Jung, Kyungdo Han, Yang‐Hyun Kim
  Journal of the American Heart Association.2023;[Epub]     CrossRef
• Risk of gastric cancer among long-term proton pump inhibitor users: a population-based cohort study
  Jong Wook Kim, Hye-Kyung Jung, Bora Lee, Cheol Min Shin, Eun Jeong Gong, Jitaek Hong, Young Hoon Youn, Kwang Jae Lee
  European Journal of Clinical Pharmacology.2023; 79(12): 1699.     CrossRef
• Cancer Risk in Elderly Korean Patients with Neurodegenerative Disease and its relation to Type 2 Diabetes
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  The Open Neurology Journal.2023;[Epub]     CrossRef
• Performance of Cardiovascular Risk Prediction Models in Korean Patients With New‐Onset Rheumatoid Arthritis: National Cohort Study
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  Journal of the American Heart Association.2023;[Epub]     CrossRef
• Impact of Propofol-based Total Intravenous Anesthesia Versus Inhalation Anesthesia on Long-term Survival After Cancer Surgery in a Nationwide Cohort
  Susie Yoon, Sun-Young Jung, Myo-Song Kim, Danbi Yoon, Younghae Cho, Yunseok Jeon
  Annals of Surgery.2023; 278(6): 1024.     CrossRef
• Decreased Risk of Knee Osteoarthritis with Taller Height in an East Asian Population: A Nationwide Cohort Study
  Dong Hwan Lee, Hwa Sung Lee, Soo Hyun Jang, Jun-Young Heu, Kyungdo Han, Se-Won Lee
  Journal of Clinical Medicine.2023; 13(1): 92.     CrossRef
• Cost-effectiveness of the anti-vascular endothelial growth factor intravitreal injection and panretinal photocoagulation for patients with proliferative diabetic retinopathy in South Korea
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• Prior Evaluation of Nutritional Status and Mortality in Patients with Sepsis in South Korea
  Tak Kyu Oh, In-Ae Song
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• Increased Risk of Hip Fracture in Patients with Acromegaly: A Nationwide Cohort Study in Korea
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  Endocrinology and Metabolism.2023; 38(6): 690.     CrossRef
• Proton Pump Inhibitor Co-Therapy in Patients with Atrial Fibrillation Treated with Oral Anticoagulants and a Prior History of Upper Gastrointestinal Tract Bleeding
  So-Ryoung Lee, Soonil Kwon, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip
  Cardiovascular Drugs and Therapy.2022; 36(4): 679.     CrossRef
• Institutional case volume-incorporated mortality risk prediction model for cardiac surgery
  Seohee Lee, Eun Jin Jang, Junwoo Jo, Dongnyeok Park, Ho Geol Ryu
  Asian Journal of Surgery.2022; 45(1): 189.     CrossRef
• Does Surgical Ablation of Atrial Fibrillation Benefit Patients Undergoing Bioprosthetic Valve Replacement?
  Won Kyung Pyo, Ho Jin Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee
  Seminars in Thoracic and Cardiovascular Surgery.2022; 34(3): 906.     CrossRef
• Burden of comorbidities and medication use in childbearing women with rheumatic diseases: a nationwide population-based study
  Min Kyung Chung, Chan Hee Lee, Jin Su Park, Hyunsun Lim, Jisoo Lee
  The Korean Journal of Internal Medicine.2022; 37(6): 1250.     CrossRef
• Validation of Dynamic Aspartate‐to–Alanine Aminotransferase Ratio for Predicting Liver Disease Mortality
  In‐Ae Song, Eun Sun Jang, Tak Kyu Oh
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• Blood Pressure Levels and Risks of Dementia: a Nationwide Study of 4.5 Million People
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  Hypertension.2022; 79(1): 218.     CrossRef
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  European Journal of Preventive Cardiology.2022; 29(3): 547.     CrossRef
• Liver enzymes and risk of ocular motor cranial nerve palsy: a nationwide population-based study
  Joonhyoung Kim, Kyungdo Han, Juhwan Yoo, Kyung-Ah Park, Sei Yeul Oh
  Neurological Sciences.2022; 43(5): 3395.     CrossRef
• Underutilisation of prophylactic G-CSF in breast cancer patients receiving adjuvant docetaxel/cyclophosphamide chemotherapy
  Minhee Ku, Nam Kyung Je
  Journal of Chemotherapy.2022; 34(8): 534.     CrossRef
• Epidemiologic study of bladder and urethral injury in Korea: A nationwide population-based study
  Bum Sik Tae, Young Eun Yoon, Woong Na, Kyung Jin Oh, Sung Yul Park, Jae Young Park, Hong Sang Moon
  Investigative and Clinical Urology.2022; 63(1): 92.     CrossRef
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  Sangmo Hong, Kyung-Soo Kim, Kyungdo Han, Cheol-Young Park
  European Heart Journal.2022; 43(15): 1491.     CrossRef
• Pericardial Versus Porcine Valves for Surgical Aortic Valve Replacement
  Hong Ju Shin, Wan Kee Kim, Jin Kyoung Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee
  Korean Circulation Journal.2022; 52(2): 136.     CrossRef
• Effect of obesity and metabolic health on urolithiasis: A nationwide population-based study
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  Investigative and Clinical Urology.2022; 63(1): 63.     CrossRef
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  Bo-Guen Kim, Minwoong Kang, Jihyun Lim, Jin Lee, Danbee Kang, Minjung Kim, Jinhee Kim, Hyejeong Park, Kyung Hoon Min, Juhee Cho, Kyeongman Jeon
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• Metabolic Disease Incidence After Allogeneic Stem Cell Transplantation: A Nationwide Korean Case-Control Study
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• Development of eClaim system for private indemnity health insurance in South Korea: Compatibility and interoperability
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  Yoonjeong Choi, Eun Young Kim, Jiyu Sun, Han-Kyoul Kim, Ye Seol Lee, Byung-Mo Oh, Hye Yoon Park, Ja-Ho Leigh
  Journal of Neurotrauma.2022; 39(5-6): 390.     CrossRef
• Female Reproductive Factors and the Risk of Bronchiectasis: A Nationwide Population-Based Longitudinal Study
  Bumhee Yang, Dong-Hwa Lee, Kyungdo Han, Hayoung Choi, Hyung Koo Kang, Dong Wook Shin, Hyun Lee
  Biomedicines.2022; 10(2): 303.     CrossRef
• Clinical outcomes of early closure versus conservative strategy after diagnosis with atrial septal defect: a nationwide population-based cohort study
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  European Journal of Cardio-Thoracic Surgery.2022;[Epub]     CrossRef
• Risk of Osteoporotic Fractures Among Obese Women Based on Body Mass Index and Waist Circumference: A Nationwide Cohort in South Korea
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  Clinical Nutrition Research.2022; 11(1): 32.     CrossRef
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  Yongil Cho, Jaehoon Oh, Jeong-Hun Shin, Byung Sik Kim, Jin-Kyu Park, Jun Ho Lee, Jae Hwan Kim, Minae Park
  Resuscitation.2022; 173: 31.     CrossRef
• Blood pressure and mortality after percutaneous coronary intervention: a population-based cohort study
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  Scientific Reports.2022;[Epub]     CrossRef
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  JAMA Network Open.2022; 5(2): e220262.     CrossRef
• Hip Fracture Risk According to Diabetic Kidney Disease Phenotype in a Korean Population
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  Endocrinology and Metabolism.2022; 37(1): 148.     CrossRef
• Non-Alcoholic Fatty Liver Disease Defined by Fatty Liver Index and Incidence of Heart Failure in the Korean Population: A Nationwide Cohort Study
  Byoungduck Han, Gyu Bae Lee, Sun Young Yim, Kyung-Hwan Cho, Koh Eun Shin, Jung-Hwan Kim, Yong-Gyu Park, Kyung-Do Han, Yang-Hyun Kim
  Diagnostics.2022; 12(3): 663.     CrossRef
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  Eun Jee Park, Nam Ju Ji, Weon Young Lee
  Journal of Psychiatric Research.2022; 149: 226.     CrossRef
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  Tae-lim Kim, Seong Jun Byun, Min Yong Seong, Byung-Mo Oh, Sang Jun Park, Han Gil Seo
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  PLOS ONE.2022; 17(4): e0266262.     CrossRef
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  Nutrients.2022; 14(8): 1644.     CrossRef
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  Journal of Clinical Oncology.2022; 40(29): 3394.     CrossRef
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  Frontiers in Neurology.2022;[Epub]     CrossRef
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  Cancers.2022; 14(11): 2604.     CrossRef
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  Hypertension.2022; 79(7): 1466.     CrossRef
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  Scientific Reports.2022;[Epub]     CrossRef
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  Hepatology Communications.2022; 6(9): 2455.     CrossRef
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  Gastroenterology.2022; 163(3): 637.     CrossRef
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  BMC Medicine.2022;[Epub]     CrossRef
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  Yonsei Medical Journal.2022; 63(8): 774.     CrossRef
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  Scientific Reports.2022;[Epub]     CrossRef
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  Journal of Personalized Medicine.2022; 12(8): 1260.     CrossRef
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  Journal of Cardiothoracic Surgery.2022;[Epub]     CrossRef
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  Hepatology Research.2022; 52(12): 975.     CrossRef
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  Diabetes & Metabolism Journal.2022; 46(5): 701.     CrossRef
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  Scientific Reports.2022;[Epub]     CrossRef
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  Frontiers in Medicine.2022;[Epub]     CrossRef
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• Low-to-moderate atmospheric ozone levels are negatively correlated with hospital visits by asthma patients
  Soyeon Lee, Minhyeok Lee
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• Acute Pancreatitis Increases the Risk of Gastrointestinal Cancer in Type 2 Diabetic Patients: A Korean Nationwide Cohort Study
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• Fasting Glucose Variability and the Risk of Dementia in Individuals with Diabetes: A Nationwide Cohort Study
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• The association between changes in hepatic steatosis and hepatic fibrosis with cardiovascular outcomes and mortality in patients with New-Onset type 2 Diabetes: A nationwide cohort study
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• Long-term outcomes of preterm infants in the first 6 years of life: a nationwide population-based study in Korea
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• Risk of malignancy in patients with psoriasis according to treatment modalities in Korea: a nationwide cohort study
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• Increased risk of cancer in patients with retinal vein occlusion: a 12-year nationwide cohort study
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• Conditional relative survival and competing mortality in patients who underwent surgery for lung cancer: A nationwide cohort study
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• Impact of Benign Prostatic Hyperplasia and/or Prostatitis on the Risk of Prostate Cancer in Korean Patients
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• High prevalence of physical inactivity after heart valve surgery and its association with long-term mortality: A nationwide cohort study
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• Association of physical activity with all-cause and cardiovascular mortality in 7666 adults with hypertrophic cardiomyopathy (HCM): more physical activity is better
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• Traditional medicine for the treatment of common cold in Korean adults: A nationwide population-based study
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• Physical activity after ischemic stroke and its association with adverse outcomes: A nationwide population-based cohort study
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• Obesity and breast cancer risk for pre- and postmenopausal women among over 6 million Korean women
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• Association of Hypertension With the Risk and Severity of Epistaxis
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• The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes – A longitudinal nationwide population-based study
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• Increased atrial fibrillation risk in Parkinson’s disease: A nationwide population‐based study
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• Risk of Cancer Following the Use of N-Nitrosodimethylamine (NDMA) Contaminated Ranitidine Products: A Nationwide Cohort Study in South Korea
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• Short- and long-term exposure to air pollution and lack of sunlight are associated with an increased risk of depression: A nested case-control study using meteorological data and national sample cohort data
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• Associations between metabolic syndrome and type of dementia: analysis based on the National Health Insurance Service database of Gangwon province in South Korea
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• Incidence and prevalence of systemic lupus erythematosus among Korean women in childbearing years: A nationwide population-based study
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• Rheumatoid arthritis in low‐level toluene‐exposed workers based on nationwide medical surveillance data in Korea
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• Status of Diabetic Neuropathy in Korea: A National Health Insurance Service-National Sample Cohort Analysis (2006 to 2015)
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• Risk factors associated with failure of total ankle arthroplasty: a nationwide cohort study
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• Survival in untreated hepatocellular carcinoma: A national cohort study
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• The incidence of myocardial infarction and stroke in head and neck cancer patients
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• Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes
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• Lifestyle is associated with atrial fibrillation development in patients with type 2 diabetes mellitus
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• The Repeatedly Elevated Fatty Liver Index Is Associated With Increased Mortality: A Population-Based Cohort Study
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• Comparative Surgical Outcomes of Prosthetic and Native Valve Endocarditis
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• Analysis of application of dental sedation in attention deficit hyperactivity disorder (ADHD) patients using the Korean National Health Insurance data
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• Deep Spinal Infection after Outpatient Epidural Injections for Pain: A Retrospective Sample Cohort Study Using a Claims Database in South Korea
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Type 2 diabetes mellitus (T2DM) is a complex endocrine and metabolic disorder, and a major public health problem that is rapidly increasing in prevalence. Although a wide range of pharmacotherapies for glycemic control is now available, management of T2DM remains complex and challenging. The kidneys contribute immensely to glucose homeostasis by reabsorbing glucose from the glomerular filtrate. Sodium-glucose cotransporter 2 (SGLT2) inhibitors, a new class of antidiabetic agents that inhibit glucose absorption from the kidney independent of insulin, offer a unique opportunity to improve the outcomes of patients with T2DM. In this review, we provide an overview of two globally-approved SGLT2 inhibitors, dapagliflozin and canagliflozin, and discuss their effects and safety. This information will help clinicians to decide whether these drugs will benefit their patients.

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