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- Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases
- Byung Soo Kong, Changhan Lee, Young Min Cho
- Diabetes Metab J. 2023;47(3):315-324. Published online February 24, 2023
- DOI: https://doi.org/10.4093/dmj.2022.0333
- 11,231 View
- 365 Download
- 6 Web of Science
- 6 Crossref
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Abstract
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PubReader 
ePub - Mitochondria are complex metabolic organelles with manifold pathophysiological implications in diabetes. Currently published mitochondrial-encoded peptides, which are expressed from the mitochondrial open reading frame of the 12S ribosomal RNA type-c (MOTS-c), 16S rRNA (humanin and short humanin like peptide 1-6 [SHLP1-6]), or small human mitochondrial open reading frame over serine tRNA (SHMOOSE) are associated with regulation of cellular metabolism and insulin action in age-related diseases, such as type 2 diabetes mellitus. This review focuses mainly on recent advances in MOTS-c research with regards to diabetes, including both type 1 and type 2. The emerging understanding of MOTS-c in diabetes may provide insight into the development of new therapies for diabetes and other age or senescence-related diseases.
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Citations
Citations to this article as recorded by
- Humanin reduces nucleus pulposus cells ferroptosis to alleviate intervertebral disc degeneration: An in vitro and in vivo study
Daxue Zhu, Zhaoheng Wang, Yanhu Li, Shijie Chen, Xuewen Kang
Journal of Orthopaedic Translation.2025; 50: 274. CrossRef - Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives
Satadeepa Kal, Sumana Mahata, Suborno Jati, Sushil K. Mahata
Peptides.2024; 172: 171147. CrossRef - Mitochondrial Stress and Mitokines: Therapeutic Perspectives for the Treatment of Metabolic Diseases
Benyuan Zhang, Joon Young Chang, Min Hee Lee, Sang-Hyeon Ju, Hyon-Seung Yi, Minho Shong
Diabetes & Metabolism Journal.2024; 48(1): 1. CrossRef - Mitochondrial bioenergetics, metabolism, and beyond in pancreatic β-cells and diabetes
Alejandra María Rivera Nieves, Brian Michael Wauford, Accalia Fu
Frontiers in Molecular Biosciences.2024;[Epub] CrossRef - Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome
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Communications Biology.2024;[Epub] CrossRef - Pyrroloquinoline Quinone Alleviates Mitochondria Damage in Radiation-Induced Lung Injury in a MOTS-c-Dependent Manner
Yanli Zhang, Jianfeng Huang, Shengpeng Li, Junlin Jiang, Jiaojiao Sun, Dan Chen, Qingfeng Pang, Yaxian Wu
Journal of Agricultural and Food Chemistry.2024; 72(38): 20944. CrossRef
- Humanin reduces nucleus pulposus cells ferroptosis to alleviate intervertebral disc degeneration: An in vitro and in vivo study
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