Diabetes & Metabolism Journal

Original Articles

Complications
Cardiovascular Autonomic Neuropathy Predicts Higher HbA1c Variability in Subjects with Type 2 Diabetes Mellitus: Yeoree Yang, Eun-Young Lee, Jae-Hyoung Cho, Yong-Moon Park, Seung-Hyun Ko, Kun-Ho Yoon, Moo-Il Kang, Bong-Yun Cha, Seung-Hwan Lee; Diabetes Metab J. 2018;42(6):496-512. Published online September 28, 2018; DOI: https://doi.org/10.4093/dmj.2018.0026

4,831 View
47 Download
10 Web of Science
9 Crossref

Abstract PDF Supplementary Material PubReader

Background

This study aimed to investigate the association between the presence and severity of cardiovascular autonomic neuropathy (CAN) and development of long-term glucose fluctuation in subjects with type 2 diabetes mellitus.

Methods

In this retrospective cohort study, subjects with type 2 diabetes mellitus who received cardiovascular autonomic reflex tests (CARTs) at baseline and at least 4-year of follow-up with ≥6 measures of glycosylated hemoglobin (HbA1c) were included. The severity of CAN was categorized as normal, early, or severe CAN according to the CARTs score. HbA1c variability was measured as the standard deviation (SD), coefficient of variation, and adjusted SD of serial HbA1c measurements.

Results

A total of 681 subjects were analyzed (294 normal, 318 early, and 69 severe CAN). The HbA1c variability index values showed a positive relationship with the severity of CAN. Multivariable logistic regression analysis showed that CAN was significantly associated with the risk of developing higher HbA1c variability (SD) after adjusting for age, sex, body mass index, diabetes duration, mean HbA1c, heart rate, glomerular filtration rate, diabetic retinopathy, coronary artery disease, insulin use, and anti-hypertensive medication (early CAN: odds ratio [OR], 1.65; 95% confidence interval [CI], 1.12 to 2.43) (severe CAN: OR, 2.86; 95% CI, 1.47 to 5.56). This association was more prominent in subjects who had a longer duration of diabetes (>10 years) and lower mean HbA1c (<7%).

Conclusion

CAN is an independent risk factor for future higher HbA1c variability in subjects with type 2 diabetes mellitus. Tailored therapy for stabilizing glucose fluctuation should be emphasized in subjects with CAN.

Citations

Citations to this article as recorded by

Intensified glycemic control by HbA1c for patients with coronary heart disease and Type 2 diabetes: a review of findings and conclusions
Jingyang Chen, Dong Yin, Kefei Dou
Cardiovascular Diabetology.2023;[Epub] CrossRef
Long-Term Risk of Cardiovascular Disease Among Type 2 Diabetes Patients According to Average and Visit-to-Visit Variations of HbA1c Levels During the First 3 Years of Diabetes Diagnosis
Hyunah Kim, Da Young Jung, Seung-Hwan Lee, Jae-Hyoung Cho, Hyeon Woo Yim, Hun-Sung Kim
Journal of Korean Medical Science.2023;[Epub] CrossRef
Factors Associated with Diabetic Complication Index among Type 2 Diabetes Patients: Focusing on Regular Outpatient Follow-up and HbA1c Variability
Haejung Lee, Gaeun Park, Ah Reum Khang
Asian Nursing Research.2023; 17(5): 259. CrossRef
The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus: A Retrospective and Observational Study
Natsumi Matsuoka-Uchiyama, Haruhito A. Uchida, Shugo Okamoto, Yasuhiro Onishi, Katsuyoshi Katayama, Mariko Tsuchida-Nishiwaki, Hidemi Takeuchi, Rika Takemoto, Yoshiko Hada, Ryoko Umebayashi, Naoko Kurooka, Kenji Tsuji, Jun Eguchi, Hirofumi Nakajima, Kenic
Journal of Diabetes Research.2022; 2022: 1. CrossRef
Perspectives of glycemic variability in diabetic neuropathy: a comprehensive review
Xiaochun Zhang, Xue Yang, Bao Sun, Chunsheng Zhu
Communications Biology.2021;[Epub] CrossRef
Assessment of Functions of the Autonomic Nervous System in the Elderly with Different Comorbid Factors
Sushma S., Medha Y. Rao, Shaikh Mohammed Aslam
Journal of Neurosciences in Rural Practice.2020; 12: 80. CrossRef
Prognostic irrelevance of plaque vulnerability following plaque sealing in high-risk patients with type 2 diabetes: an optical coherence tomography study
Rosalia Dettori, Andrea Milzi, Kathrin Burgmaier, Mohammad Almalla, Martin Hellmich, Nikolaus Marx, Sebastian Reith, Mathias Burgmaier
Cardiovascular Diabetology.2020;[Epub] CrossRef
HbA1C Variability Is Strongly Associated With the Severity of Cardiovascular Autonomic Neuropathy in Patients With Type 2 Diabetes After Longer Diabetes Duration
Yun-Ru Lai, Chih-Cheng Huang, Wen-Chan Chiu, Rue-Tsuan Liu, Nai-Wen Tsai, Hung-Chen Wang, Wei-Che Lin, Ben-Chung Cheng, Yu-Jih Su, Chih-Min Su, Sheng-Yuan Hsiao, Pei-Wen Wang, Jung-Fu Chen, Cheng-Hsien Lu
Frontiers in Neuroscience.2019;[Epub] CrossRef
Polyscore of Non-invasive Cardiac Risk Factors
Alexander Steger, Alexander Müller, Petra Barthel, Michael Dommasch, Katharina Maria Huster, Katerina Hnatkova, Daniel Sinnecker, Alexander Hapfelmeier, Marek Malik, Georg Schmidt
Frontiers in Physiology.2019;[Epub] CrossRef

Clinical Care/Education
Physician-Directed Diabetes Education without a Medication Change and Associated Patient Outcomes: Hun-Sung Kim, Hyunah Kim, Hae-Kyung Yang, Eun Young Lee, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung-Hwan Lee, Jae Hyoung Cho, In Young Choi, Hyeon Woo Yim, Bong-Yun Cha; Diabetes Metab J. 2017;41(3):187-194. Published online May 12, 2017; DOI: https://doi.org/10.4093/dmj.2017.41.3.187

4,898 View
40 Download
1 Web of Science
3 Crossref

Abstract PDF PubReader

Background

When patients with diabetes mellitus (DM) are first referred to a hospital from primary health care clinics, physicians have to decide whether to administer an oral hypoglycemic agent (OHA) immediately or postpone a medication change in favor of diabetes education regarding diet or exercise. The aim of this study was to determine the effect of diabetes education alone (without alterations in diabetes medication) on blood glucose levels.

Methods

The study was conducted between January 2009 and December 2013 and included patients with DM. The glycosylated hemoglobin (HbA1c) levels were evaluated at the first visit and after 3 months. During the first medical examination, a designated doctor also conducted a diabetes education session that mainly covered dietary management.

Results

Patients were divided into those who received no diabetic medications (n=66) and those who received an OHA (n=124). Education resulted in a marked decrease in HbA1c levels in the OHA group among patients who had DM for <1 year (from 7.0%±1.3% to 6.6%±0.9%, P=0.0092) and for 1 to 5 years (from 7.5%±1.8% to 6.9%±1.1%, P=0.0091). Those with DM >10 years showed a slightly lower HbA1c target achievement rate of <6.5% (odds ratio, 0.089; P=0.0024).

Conclusion

For patients who had DM for more than 5 years, higher doses or changes in medication were more effective than intensive active education. Therefore, individualized and customized education are needed for these patients. For patients with a shorter duration of DM, it may be more effective to provide initial intensive education for diabetes before prescribing medicines, such as OHAs.

Citations

Citations to this article as recorded by

Management Status of Patients with Type 2 Diabetes Mellitus at General Hospitals in Korea: A 5-Year Follow-Up Study
Jin Hee Jung, Jung Hwa Lee, Hyang Mi Jang, Young Na, Hee Sun Choi, Yeon Hee Lee, Yang Gyo Kang, Na Rae Kim, Jeong Rim Lee, Bok Rye Song, Kang Hee Sim
The Journal of Korean Diabetes.2022; 23(1): 64. CrossRef
Effect of Voluntary Participation on Mobile Health Care in Diabetes Management: Randomized Controlled Open-Label Trial
Da Young Lee, Seung-Hyun Yoo, Kyong Pil Min, Cheol-Young Park
JMIR mHealth and uHealth.2020; 8(9): e19153. CrossRef
Developing a multi-center clinical data mart of ACEI and ARB for real-world evidence (RWE)
Hun-Sung Kim, Sue Hyun Lee, Tong Min Kim, Ju Han Kim
Clinical Hypertension.2018;[Epub] CrossRef

Effects of 6-Month Sitagliptin Treatment on Insulin and Glucagon Responses in Korean Patients with Type 2 Diabetes Mellitus: Hae Kyung Yang, Borami Kang, Seung-Hwan Lee, Hun-Sung Kim, Kun-Ho Yoon, Bong-Yun Cha, Jae-Hyoung Cho; Diabetes Metab J. 2015;39(4):335-341. Published online July 17, 2015; DOI: https://doi.org/10.4093/dmj.2015.39.4.335

4,153 View
36 Download
4 Web of Science
3 Crossref

Abstract PDF PubReader

Background

This study aimed to evaluate the effect of sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, on insulin secretion and glucagon suppression in Korean subjects with type 2 diabetes mellitus.

Methods

Twenty-four subjects underwent a 75-g oral glucose tolerance test (OGTT) before and after 6 months of sitagliptin treatment. Sitagliptin, insulin, and sulfonylurea were withdrawn for 3 days before OGTT to eliminate any acute effects on β-cell insulin or α-cell glucagon secretion. Venous samples were drawn five times during each OGTT to measure plasma glucose, insulin, and glucagon. Indices on insulin secretion and resistance were calculated.

Results

Early phase insulin secretion, measured by the insulinogenic index significantly increased after 6 months of sitagliptin treatment, especially in the higher baseline body mass index group and higher baseline glycosylated hemoglobin (HbA1c) group. There were no significant differences in the insulin resistance indices before and after sitagliptin treatment. Although no significant differences were observed in the absolute levels of glucagon and the glucagon-to-insulin ratio, there was a significant reduction in the percentile change of glucagon-to-insulin ratio at 30- and 120-minute during the OGTT.

Conclusion

Although the HbA1c level did not decrease significantly after 6 months of sitagliptin treatment, an increase in insulin secretion and reduction in early phase postprandial plasma glucagon-to-insulin ratio excursion was confirmed in Korean subjects with type 2 diabetes.

Citations

Citations to this article as recorded by

A genetic variant in GLP1R is associated with response to DPP-4 inhibitors in patients with type 2 diabetes
Eugene Han, Hye Sun Park, Obin Kwon, Eun Yeong Choe, Hye Jin Wang, Yong-ho Lee, Sang-Hak Lee, Chul Hoon Kim, Lee-Kyung Kim, Soo Heon Kwak, Kyong Soo Park, Chul Sik Kim, Eun Seok Kang
Medicine.2016; 95(44): e5155. CrossRef
Effects of sitagliptin on circulating zinc-α2-glycoprotein levels in newly diagnosed type 2 diabetes patients: a randomized trial
Mingyuan Tian, Zerong Liang, Rui Liu, Ke Li, Xinrong Tan, Yong Luo, Mengliu Yang, Harvest F Gu, Hua Liu, Ling Li, Gangyi Yang
European Journal of Endocrinology.2016; 174(2): 147. CrossRef
Effects of Sitagliptin on Insulin and Glucagon Levels in Type 2 Diabetes Mellitus
Ji Hyun Kim
Diabetes & Metabolism Journal.2015; 39(4): 304. CrossRef

Current Status of Glycemic Control of Patients with Diabetes in Korea: The Fifth Korea National Health and Nutrition Examination Survey: Ja Young Jeon, Dae Jung Kim, Seung-Hyun Ko, Hyuk-Sang Kwon, Soo Lim, Sung Hee Choi, Chul Sik Kim, Jee Hyun An, Nan Hee Kim, Jong Chul Won, Jae Hyeon Kim, Bong-Yun Cha, Kee-Ho Song; Diabetes Metab J. 2014;38(3):197-203. Published online June 17, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.3.197

5,104 View
59 Download
46 Web of Science
51 Crossref

Abstract PDF PubReader

Background

The Korea National Health and Nutrition Examination Survey (KNHANES) III (2005) reported that 22.9% of individuals with diabetes have a glycated hemoglobin (HbA1c) <6.5% and that 43.5% have an HbA1c <7%. We investigated the levels of glycemic control and the factors associated with glycemic control using data from the KNHANES V (2010 to 2012).

Methods

Subjects with diabetes diagnosed by a physician or those taking antidiabetic medications were classified as individuals with known diabetes. Of 1,498 subjects aged ≥30 years with diabetes, we excluded 157 individuals who were missing HbA1c data. A total of 1,341 subjects were included in the final analysis.

Results

The prevalence of known diabetes was 7.7% (n=1,498, estimated to be 2.32 million people). The proportions of well-controlled diabetes meeting a HbA1c goal of <6.5% and <7% were 27% and 45.6%, respectively. HbA1c increased as the duration of diabetes increased. HbA1c in subjects with a duration of diabetes ≤5 years was lower than in subjects with a duration >5 years. HbA1c in the group taking only oral hypoglycemic agents (OHAs) was significantly lower than that in the group administered only insulin or OHA and insulin in combination. In logistic regression analysis, a longer duration of diabetes, insulin use and the absence of chronic renal failure were associated with HbA1c levels >6.5%.

Conclusion

The level of adequate glycemic control was similar to but slightly improved compared with previous levels. The glycemic control of long-standing diabetes patients is more difficult even though they receive insulin treatment.

Citations

Citations to this article as recorded by

Real-time continuous glucose monitoring vs. self-monitoring of blood glucose: cost-utility in South Korean type 2 diabetes patients on intensive insulin
Ji Yoon Kim, Sabrina Ilham, Hamza Alshannaq, Richard F. Pollock, Waqas Ahmed, Gregory J. Norman, Sang-Man Jin, Jae Hyeon Kim
Journal of Medical Economics.2024; : 1. CrossRef
Therapeutic Effects of Switching to Anagliptin from Other DPP-4 Inhibitors in T2DM Patients with Inadequate Glycemic Control: A Non-interventional, Single-Arm, Open-Label, Multicenter Observational Study
Sang-Yong Kim, Sungrae Kim
Diabetes Therapy.2023; 14(1): 109. CrossRef
Information and Communications Technology (ICT)-based Monitoring Service for Tailored Chronic Disease Management in Primary Care: Cost-Effectiveness Analysis based on ICT-CM Trial Results (Preprint)
Sung-Hee Oh, Jae-Heon Kang, Jin-Won Kwon
Journal of Medical Internet Research.2023;[Epub] CrossRef
Declined incidence of patients treated for vision-threatening diabetic retinopathy in South Korea: a 12-year nationwide population-based study
Jiwon Kim, Hyojin Seong, Kang Ju Son, Eun Jee Chung
Graefe's Archive for Clinical and Experimental Ophthalmology.2022; 260(1): 101. CrossRef
Glycemic status and general characteristics among individuals with undiagnosed diabetes; findings from second National Diabetes Survey of Pakistan 2016–2017 (NDSP 08)
Abdul Basit, Nazish Waris, Asher Fawwad, Bilal Tahir, Iftikhar Ahmed Siddiqui, Mujeeb Ur Rehman Abro, Khawaja Ishfaq Ahmed, Khurshid Ahmed, Sobia Sabir Ali, Ahmed Bilal, Anam Butt, Bikha Ram Devrajani, Ijaz Hayder, Yasir Humayun, Rabia Irshad, Riasat Ali
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2022; 16(6): 102535. CrossRef
Glycemic control and its determinants among people with type 2 diabetes mellitus in Ernakulam district, Kerala
ShanaShirin Najeeb, TeenaMary Joy, Aswathy Sreedevi, K Vijayakumar, Syama, . Glycaemic Control and Determinants Team
Indian Journal of Public Health.2022; 66(5): 80. CrossRef
C-peptide level as predictor of type 2 diabetes remission and body composition changes in non-diabetic and diabetic patients after Roux-en-Y gastric bypass
Roberto de Cleva, Flavio Kawamoto, Georgia Borges, Priscila Caproni, Alex Jones Flores Cassenote, Marco Aurelio Santo
Clinics.2021; 76: e2906. CrossRef
Inadequate achievement of ABC goals (HbA1c, blood pressure, LDL-C) among patients with type 2 diabetes in an Iranian population, 2012–2017
Mehrdad Larry, Saeid Alizadeh, Sina Naderi, Bahareh Salekani, Mohammad Ali Mansournia, Soghra Rabizadeh, Alireza Esteghamati, Manouchehr Nakhjavani
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(4): 619. CrossRef
Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea
Suk Kyeong Kim, Ju-Young Jang, Dong-Lim Kim, Young A Rhyu, Suh Eun Lee, Seung-Hyun Ko, Kyungdo Han, Kee-Ho Song
The Korean Journal of Internal Medicine.2020; 35(3): 641. CrossRef
The development of oral semaglutide, an oral GLP-1 analog, for the treatment of type 2 diabetes
Mads Frederik Rasmussen
Diabetology International.2020; 11(2): 76. CrossRef
An Assessment of Pharmacokinetic Interaction Between Lobeglitazone and Sitagliptin After Multiple Oral Administrations in Healthy Men
Seol Ju Moon, Kyung-Sang Yu, Min-Gul Kim
Clinical Therapeutics.2020; 42(6): 1047. CrossRef
Nationwide Trends in Pancreatitis and Pancreatic Cancer Risk Among Patients With Newly Diagnosed Type 2 Diabetes Receiving Dipeptidyl Peptidase 4 Inhibitors
Minyoung Lee, Jiyu Sun, Minkyung Han, Yongin Cho, Ji-Yeon Lee, Chung Mo Nam, Eun Seok Kang
Diabetes Care.2019; 42(11): 2057. CrossRef
Factors Influencing Glycemic Control among Type 2 Diabetes Mellitus Patients: The Sixth Korea National Health and Nutrition Examination Survey (2013~2015)
Mee Ock Gu
Korean Journal of Adult Nursing.2019; 31(3): 235. CrossRef
Trends in metabolic risk factors among patients with diabetes mellitus according to income levels: the Korea National Health and Nutrition Examination Surveys 1998 ~ 2014
Sukyung Cho, Kyong Park
Journal of Nutrition and Health.2019; 52(2): 206. CrossRef
Current status of treatment of type 2 diabetes mellitus in Ningbo, China
Tianmeng Yang, Rongjiong Zheng, Qingmei Chen, Yushan Mao
Journal of Clinical Laboratory Analysis.2019;[Epub] CrossRef
Trends in the prevalence and management of diabetes in Korea: 2007-2017
Ji-Yeon Shin
Epidemiology and Health.2019; 41: e2019029. CrossRef
Diabetes Fact Sheets in Korea, 2018: An Appraisal of Current Status
Bo-Yeon Kim, Jong Chul Won, Jae Hyuk Lee, Hun-Sung Kim, Jung Hwan Park, Kyoung Hwa Ha, Kyu Chang Won, Dae Jung Kim, Kyong Soo Park
Diabetes & Metabolism Journal.2019; 43(4): 487. CrossRef
A new comprehensive diabetes health literacy scale: Development and psychometric evaluation
Eun-Hyun Lee, Young Whee Lee, Kwan-Woo Lee, Moonsuk Nam, So Hun Kim
International Journal of Nursing Studies.2018; 88: 1. CrossRef
Women are less likely than men to achieve optimal glycemic control after 1 year of treatment: A multi-level analysis of a Korean primary care cohort
Seung-Ah Choe, Joo Yeong Kim, Young Sun Ro, Sung-Il Cho, Antonio Palazón-Bru
PLOS ONE.2018; 13(5): e0196719. CrossRef
Ten-Year Mortality Trends for Adults with and without Diabetes Mellitus in South Korea, 2003 to 2013
Kyeong Jin Kim, Tae Yeon Kwon, Sungwook Yu, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Sin Gon Kim, Yousung Park, Nam Hoon Kim
Diabetes & Metabolism Journal.2018; 42(5): 394. CrossRef
Comparison of Adherence to Glimepiride/Metformin Sustained Release Once-daily Versus Glimepiride/Metformin Immediate Release BID Fixed-combination Therapy Using the Medication Event Monitoring System in Patients With Type 2 Diabetes
Jong-Dai Kim, Cheol-Young Park, Bong-Yun Cha, Kyu Jeung Ahn, In Joo Kim, Kyong Soo Park, Hyung Woo Lee, Kyung-Wan Min, Jong Chul Won, Min Young Chung, Jae-Taek Kim, Jun Goo Kang, Sung-Woo Park
Clinical Therapeutics.2018; 40(5): 752. CrossRef
Negative Association of Hepatitis B Virus With Hearing Impairment
SKM Azizul Islam, Jin Wook Chung, Young-Sil Lee, HoChan Cho, Seong-Su Moon
American Journal of Audiology.2018; 27(3): 324. CrossRef
The effectiveness, reproducibility, and durability of tailored mobile coaching on diabetes management in policyholders: A randomized, controlled, open-label study
Da Young Lee, Jeongwoon Park, Dooah Choi, Hong-Yup Ahn, Sung-Woo Park, Cheol-Young Park
Scientific Reports.2018;[Epub] CrossRef
Prediction of Type 2 Diabetes Remission after Bariatric or Metabolic Surgery
Ji Yeon Park
Journal of Obesity & Metabolic Syndrome.2018; 27(4): 213. CrossRef
Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis
Seung-Hyun Ko, Kyungdo Han, Yong-ho Lee, Junghyun Noh, Cheol-Young Park, Dae-Jung Kim, Chang Hee Jung, Ki-Up Lee, Kyung-Soo Ko
Diabetes & Metabolism Journal.2018; 42(2): 93. CrossRef
Prediction of Diabetes Remission after Bariatric or Metabolic Surgery
Ji Yeon Park
Journal of Metabolic and Bariatric Surgery.2018; 7(1): 22. CrossRef
Detrimental Effects of Higher Body Mass Index and Smoking Habits on Menstrual Cycles in Korean Women
An Na Jung, Ju Hwan Park, Jihyun Kim, Seok Hyun Kim, Byung Chul Jee, Byung Heun Cha, Jae Woong Sull, Jin Hyun Jun
Journal of Women's Health.2017; 26(1): 83. CrossRef
Improved trends in cardiovascular complications among subjects with type 2 diabetes in Korea: a nationwide study (2006–2013)
Chang Hee Jung, Jin Ook Chung, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko, Joong-Yeol Park
Cardiovascular Diabetology.2017;[Epub] CrossRef
The differences in the incidence of diabetes mellitus and prediabetes according to the type of HMG-CoA reductase inhibitors prescribed in Korean patients
Tong Min Kim, Hyunah Kim, Yoo Jin Jeong, Sun Jung Baik, So Jung Yang, Seung-Hwan Lee, Jae-Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun-Ho Yoon, Hun-Sung Kim
Pharmacoepidemiology and Drug Safety.2017; 26(10): 1156. CrossRef
Euglycemic Diabetic Ketoacidosis When Reducing Insulin Dosage in Patients Taking Sodium Glucose Cotransporter 2 Inhibitor
Woo Jin Yi, Soo-Kyung Kim, Sun Ung Youn, Namkyu Kang, Myung Won Lee, Seok O Park
The Ewha Medical Journal.2017; 40(1): 55. CrossRef
Effectiveness of Vildagliptin in Clinical Practice: Pooled Analysis of Three Korean Observational Studies (the VICTORY Study)
Sunghwan Suh, Sun Ok Song, Jae Hyeon Kim, Hyungjin Cho, Woo Je Lee, Byung-Wan Lee
Journal of Diabetes Research.2017; 2017: 1. CrossRef
Prevalence and risk factors for reduced pulmonary function in diabetic patients: The Korea National Health and Nutrition Examination Survey
Hee Yeon Kim, Tae Seo Sohn, Hannah Seok, Chang Dong Yeo, Young Soo Kim, Jae Yen Song, Young Bok Lee, Dong-Hee Lee, Jae-Im Lee, Tae-Kyu Lee, Seong Cheol Jeong, Mihee Hong, Hiun Suk Chae
The Korean Journal of Internal Medicine.2017; 32(4): 682. CrossRef
Delay of insulin initiation in patients with type 2 diabetes mellitus inadequately controlled with oral hypoglycemic agents (analysis of patient‐ and physician‐related factors): A prospective observational DIPP‐FACTOR study in Korea
Sin Gon Kim, Nam Hoon Kim, Bon Jeong Ku, Ho Sang Shon, Doo Man Kim, Tae Sun Park, Yong‐Seong Kim, In Joo Kim, Dong Seop Choi
Journal of Diabetes Investigation.2017; 8(3): 346. CrossRef
Effectiveness and safety of exenatide in Korean patients with type 2 diabetes inadequately controlled with oral hypoglycemic agents: an observational study in a real clinical practice
You-Cheol Hwang, Ari Kim, Euna Jo, Yeoree Yang, Jae-Hyoung Cho, Byung-Wan Lee
BMC Endocrine Disorders.2017;[Epub] CrossRef
Current status of managing diabetes mellitus in Korea
Kyoung Hwa Ha, Dae Jung Kim
The Korean Journal of Internal Medicine.2016; 31(5): 845. CrossRef
Trends of antidiabetic drug use in adult type 2 diabetes in Korea in 2002–2013
Seung-Hyun Ko, Dae-Jung Kim, Jong-Heon Park, Cheol-Young Park, Chang Hee Jung, Hyuk-Sang Kwon, Joong-Yeol Park, Kee-Ho Song, Kyungdo Han, Ki-Up Lee, Kyung-Soo Ko
Medicine.2016; 95(27): e4018. CrossRef
A patient-centric approach to optimise insulin therapy in Asia
Su Yen Goh, Ernesto Ang, Shailendra Bajpai, Chaicharn Deerochanawong, Eun-Gyoung Hong, Zanariah Hussein, Shashank Joshi, Nor Azmi Kamaruddin, Sjoberg Kho, Alice Pik-Shan Kong, Chang Yu Pan, Riccardo Perfetti, Apichati Vichayanrat, Aleksandra Vlajnic, Juli
Journal of Diabetes and its Complications.2016; 30(6): 973. CrossRef
Association between blood glucose level derived using the oral glucose tolerance test and glycated hemoglobin level
Hyoung Joo Kim, Young Geon Kim, Jin Soo Park, Young Hwan Ahn, Kyoung Hwa Ha, Dae Jung Kim
The Korean Journal of Internal Medicine.2016; 31(3): 535. CrossRef
Social Networking Services-Based Communicative Care for Patients with Diabetes Mellitus in Korea
Hun-Sung Kim, Yoo Jeong, Sun Baik, So Yang, Tong Kim, Hyunah Kim, Hyunyong Lee, Seung-Hwan Lee, Jae Cho, In-Young Choi, Kun-Ho Yoon
Applied Clinical Informatics.2016; 07(03): 899. CrossRef
Factors Associated with Poor Glycemic Control among Patients with Type 2 Diabetes Mellitus: The Fifth Korea National Health and Nutrition Examination Survey (2010-2012)
Jinhyun Park, Seungji Lim, Eunshil Yim, Youngdae Kim, Woojin Chung
Health Policy and Management.2016; 26(2): 125. CrossRef
Reduction of Sulfonylurea with the Initiation of Basal Insulin in Patients with Inadequately Controlled Type 2 Diabetes Mellitus Undergoing Long-Term Sulfonylurea-Based Treatment
Yeoree Yang, Jeong-Ah Shin, Hae Kyung Yang, Seung-Hwan Lee, Seung-Hyun Ko, Yu-Bae Ahn, Kun-Ho Yoon, Jae-Hyoung Cho
Diabetes & Metabolism Journal.2016; 40(6): 454. CrossRef
Health inequalities in hypertension and diabetes management among the poor in urban areas: a population survey analysis in south Korea
Young-Jee Jeon, Chung Reen Kim, Joo-Sung Park, Kyung-Hyun Choi, Myoung Joo Kang, Seung Guk Park, Young-Jin Park
BMC Public Health.2016;[Epub] CrossRef
Prediction of Diabetes Remission in Morbidly Obese Patients After Roux-en-Y Gastric Bypass
Ji Yeon Park, Yong Jin Kim
Obesity Surgery.2016; 26(4): 749. CrossRef
Inhibition of advanced glycation end product formation by burdock root extract
Darye Lee, Choon Young Kim
Journal of Nutrition and Health.2016; 49(4): 233. CrossRef
Diabetes in Asians
Eun-Jung Rhee
Endocrinology and Metabolism.2015; 30(3): 263. CrossRef
Insulin Initiation in Insulin-Naïve Korean Type 2 Diabetic Patients Inadequately Controlled on Oral Antidiabetic Drugs in Real-World Practice: The Modality of Insulin Treatment Evaluation Study
Sang Soo Kim, In Joo Kim, Yong Ki Kim, Kun Ho Yoon, Ho Young Son, Sung Woo Park, Yeon Ah Sung, Hong Sun Baek
Diabetes & Metabolism Journal.2015; 39(6): 481. CrossRef
Current status of glucose, blood pressure and lipid management in type 2 diabetes clinic attendees in Isfahan, Iran
Mohsen Janghorbani, Bahman Papi, Masoud Amini
Journal of Diabetes Investigation.2015; 6(6): 716. CrossRef
Trends in the Diabetes Epidemic in Korea
Kyoung Hwa Ha, Dae Jung Kim
Endocrinology and Metabolism.2015; 30(2): 142. CrossRef
The Side Effects of Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor
Won Jin Kim, Sang Soo Kim
The Journal of Korean Diabetes.2014; 15(3): 158. CrossRef
It's Still Not Too Late to Make a Change: Current Status of Glycemic Control in Korea
Sang Yong Kim
Diabetes & Metabolism Journal.2014; 38(3): 194. CrossRef
Association between Diabetes Education Status and Clinical Outcomes of Patients with Diabetes Mellitus: Analysis of the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V)
Jun Sung Kwon, Won Jun Kim, Yang Hee Han, Hyun Joong Kim, Sa Young Shin, Kyoo Ho Choi, Jae Hyuck Jun, Myoung Sook Shim, Jin Yeob Kim
The Journal of Korean Diabetes.2014; 15(4): 236. CrossRef

Prevalence and Determinants of Diabetic Nephropathy in Korea: Korea National Health and Nutrition Examination Survey: Jae Hee Ahn, Ji Hee Yu, Seung-Hyun Ko, Hyuk-Sang Kwon, Dae Jung Kim, Jae Hyeon Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Soo Lim, Sung Hee Choi, Kyungdo Han, Bong-Yun Cha, Nan Hee Kim; Diabetes Metab J. 2014;38(2):109-119. Published online April 18, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.2.109

6,171 View
107 Download
59 Web of Science
59 Crossref

Abstract PDF PubReader

Background

Diabetic nephropathy is a leading cause of end stage renal disease and is associated with an increased risk of cardiovascular mortality. It manifests as albuminuria or impaired glomerular filtration rate (GFR), and the prevalence of diabetic nephropathy varies with ethnicity. The prevalence of diabetic nephropathy and its determinants in Korean adults have not previously been studied at the national level. This cross-sectional study was undertaken to ascertain the prevalence and determinants of albuminuria and chronic kidney disease (CKD) in Korean patients with diabetes.

Methods

The Korea National Health and Nutrition Examination Survey (KNHANES) V, conducted in 2011, was used to define albuminuria (n=4,652), and the dataset of KNHANES IV-V (2008-2011) was used to define CKD (n=21,521). Selected samples were weighted to represent the entire civilian population in Korea. Albuminuria was defined as a spot urine albumin/creatinine ratio >30 mg/g. CKD was defined as a GFR <60 mL/min/1.73 m².

Results

Among subjects with diabetes, 26.7% had albuminuria, and 8.6% had CKD. Diabetes was associated with an approximate 2.5-fold increased risk of albuminuria, with virtually no difference between new-onset and previously diagnosed diabetes. Only systolic blood pressure was significantly associated with albuminuria, and old age, high serum triglyceride levels, and previous cardiovascular disease (CVD) were related with CKD in subjects with diabetes.

Conclusion

Korean subjects with diabetes had a higher prevalence of albuminuria and CKD than those without diabetes. Blood pressure was associated with albuminuria, and age, triglyceride level, and previous CVD were independent determinants of CKD in subjects with diabetes.

Citations

Citations to this article as recorded by

Associations between dietary patterns and renal impairment in individuals with diabetes: a cross‐sectional study
Ziling Ding, Xingzhe Wu, Chao Liu, Ruixue Ying, Yi Zhang, Shiqi Zhang, Qiu Zhang, Honglin Hu, Fang Dai
Journal of Human Nutrition and Dietetics.2024; 37(1): 193. CrossRef
Determinants of diabetic nephropathy among adult diabetic patients on follow-up at public hospitals in Addis Ababa, Ethiopia: A case-control study
Diriba Etana Tola, Zenebu Begna Bayissa, Tamene Abera Desissa, Lencho Kajela Solbana, Azeb Haile Tesfaye, Bikila Fufa Eba
SAGE Open Medicine.2024;[Epub] CrossRef
Kidney Health Plan 2033 in Korea: bridging the gap between the present and the future
Do Hyoung Kim, Young Youl Hyun, Jin Joo Cha, Sua Lee, Hyun Kyung Lee, Jong Wook Choi, Su-Hyun Kim, Sang Youb Han, Cheol Whee Park, Eun Young Lee, Dae Ryong Cha, Sung Gyun Kim, Chun Soo Lim, Sun-Hee Park
Kidney Research and Clinical Practice.2024; 43(1): 8. CrossRef
2023 Diabetic Kidney Disease Fact Sheet in Korea
Nam Hoon Kim, Mi-Hae Seo, Jin Hyung Jung, Kyung Do Han, Mi Kyung Kim, Nan Hee Kim
Diabetes & Metabolism Journal.2024; 48(3): 463. CrossRef
Risk Factors of Microalbuminuria among Patients with Type 2 Diabetes Mellitus in Korea: A Cross-Sectional Study Based on 2019–2020 Korea National Health and Nutrition Examination Survey Data
Eun Sook Bae, Jung Yi Hur, Hyung Soon Jang, Jeong Suk Kim, Hye Seung Kang
International Journal of Environmental Research and Public Health.2023; 20(5): 4169. CrossRef
CORRELATION OF VASCULAR ENDOTHELIAL FUNCTION AND INFLAMMATORY FACTORS WITH RENAL FUNCTION IN PATIENTS WITH DIABETIC NEPHROPATHY
A. Y. Mammadzada, Sh. G. Ismayilova, Sh. S. Ibrahimova, N. I. Huseynova, L. A. Huseyn
World of Medicine and Biology.2023; 19(85): 129. CrossRef
Synopsis of the Korean Society of Nephrology 2023 Practical Recommendations for the Management of Diabetic Kidney Disease
Sungjin Chung
The Korean Journal of Medicine.2023; 98(6): 270. CrossRef
3-Hydroxybutyrate Ameliorates the Progression of Diabetic Nephropathy
Jeeyoun Jung, Woo Yeong Park, Yun Jin Kim, Mikyung Kim, Misun Choe, Kyubok Jin, Ji Hae Seo, Eunyoung Ha
Antioxidants.2022; 11(2): 381. CrossRef
Development and Validation of a Model That Predicts the Risk of Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study
Jing Yang, Sheng Jiang
International Journal of General Medicine.2022; Volume 15: 5089. CrossRef
Renoprotective Mechanism of Sodium-Glucose Cotransporter 2 Inhibitors: Focusing on Renal Hemodynamics
Nam Hoon Kim, Nan Hee Kim
Diabetes & Metabolism Journal.2022; 46(4): 543. CrossRef
Development and assessment of diabetic nephropathy prediction model using hub genes identified by weighted correlation network analysis
Xuelian Zhang, Yao Wang, Zhaojun Yang, Xiaoping Chen, Jinping Zhang, Xin Wang, Xian Jin, Lili Wu, Xiaoyan Xing, Wenying Yang, Bo Zhang
Aging.2022; 14(19): 8095. CrossRef
Neutrophil–lymphocyte ratio as an inflammatory biomarker of diabetic nephropathy among type 2 diabetes mellitus patients: A comparative cross-sectional study
Mesfin Zewude Gurmu, Solomon Genet, Solomon Tebeje Gizaw, Teka Obsa Feyisa, Natesan Gnanasekaran
SAGE Open Medicine.2022; 10: 205031212211402. CrossRef
Did Sejong the Great have ankylosing spondylitis? The oldest documented case of ankylosing spondylitis
JiHwan Lee
International Journal of Rheumatic Diseases.2021; 24(2): 203. CrossRef
Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy
Jeong Suk Kang, Seung Seob Son, Ji-Hye Lee, Seong Woo Lee, Ah Reum Jeong, Eun Soo Lee, Seung-Kuy Cha, Choon Hee Chung, Eun Young Lee, Partha Mukhopadhyay
PLOS ONE.2021; 16(4): e0250666. CrossRef
Nomogram for the prediction of diabetic nephropathy risk among patients with type 2 diabetes mellitus based on a questionnaire and biochemical indicators: a retrospective study
Yuhong Hu, Rong Shi, Ruohui Mo, Fan Hu
Aging.2020; 12(11): 10317. CrossRef
Differential Urinary Proteome Analysis for Predicting Prognosis in Type 2 Diabetes Patients with and without Renal Dysfunction
Hee-Sung Ahn, Jong Ho Kim, Hwangkyo Jeong, Jiyoung Yu, Jeonghun Yeom, Sang Heon Song, Sang Soo Kim, In Joo Kim, Kyunggon Kim
International Journal of Molecular Sciences.2020; 21(12): 4236. CrossRef
Urine E-cadherin: A Marker for Early Detection of Kidney Injury in Diabetic Patients
Michael Koziolek, Gerhard A. Mueller, Gry H. Dihazi, Klaus Jung, Constanze Altubar, Manuel Wallbach, Ivana Markovic, Dirk Raddatz, Olaf Jahn, Hülya Karaköse, Christof Lenz, Henning Urlaub, Abdelhi Dihazi, Abdellatif El El Meziane, Hassan Dihazi
Journal of Clinical Medicine.2020; 9(3): 639. CrossRef
Study of serum pentraxin 3 level in patients with diabetic nephropathy
Alaaeldin Abdelsalam Dawood, Mai Ashraf Kamel, Thoria Ahmed Omar, Ahmed Ahmed Mohammed Agaba
The Egyptian Journal of Internal Medicine.2020;[Epub] CrossRef
Limitations of Deep Learning Attention Mechanisms in Clinical Research: Empirical Case Study Based on the Korean Diabetic Disease Setting
Junetae Kim, Sangwon Lee, Eugene Hwang, Kwang Sun Ryu, Hanseok Jeong, Jae Wook Lee, Yul Hwangbo, Kui Son Choi, Hyo Soung Cha
Journal of Medical Internet Research.2020; 22(12): e18418. CrossRef
Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea
Seo Yeon Baik, Hyunah Kim, So Jung Yang, Tong Min Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon, Hun-Sung Kim
Frontiers of Medicine.2019; 13(6): 713. CrossRef
Plasma endoglin in Type2 diabetic patients with nephropathy
Ahmed S. Doghish, Atef A. Bassyouni, Mohamed H. Mahfouz, Heba G. Abd El-Aziz, Rania Y. Zakaria
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 764. CrossRef
Cigarette smoking as a risk factor for diabetic nephropathy: A systematic review and meta-analysis of prospective cohort studies
Dan Liao, Liang Ma, Jing Liu, Ping Fu, Noël C. Barengo
PLOS ONE.2019; 14(2): e0210213. CrossRef
Risk factors for diabetic nephropathy complications in community patients with type 2 diabetes mellitus in Shanghai: Logistic regression and classification tree model analysis
Jieqiong Lou, Limei Jing, Hui Yang, Fei Qin, Wen Long, Rong Shi
The International Journal of Health Planning and Management.2019; 34(3): 1013. CrossRef
Predictive Factors for Efficacy of AST-120 Treatment in Diabetic Nephropathy: a Prospective Single-Arm, Open-Label, Multi-Center Study
You-Cheol Hwang, Se Won Kim, Kyu Yeon Hur, Bong-Soo Cha, In Joo Kim, Tae Sun Park, Sei Hyun Baik, Kun Ho Yoon, Kwan Woo Lee, In Kyu Lee, Moon-Kyu Lee
Journal of Korean Medical Science.2019;[Epub] CrossRef
Glycated Albumin Is a More Useful Glycation Index than HbA1c for Reflecting Renal Tubulopathy in Subjects with Early Diabetic Kidney Disease
Ji Hye Huh, Minyoung Lee, So Young Park, Jae Hyeon Kim, Byung-Wan Lee
Diabetes & Metabolism Journal.2018; 42(3): 215. CrossRef
Meta‑analysis of the benefit of sitagliptin treatment in patients with type 2 diabetes complicated with incipient nephropathy
Wei Liu, Jiangyi Yu, Qianhua Yan, Lijuan Wang, Nan Li, Wei Xiong
Experimental and Therapeutic Medicine.2018;[Epub] CrossRef
MicroRNA‐326‐3p ameliorates high glucose and ox‐LDL‐IC‐ induced fibrotic injury in renal mesangial cells by targeting FcγRIII
Yiting Wang, Rui Zhang, Junlin Zhang, Fang Liu
Nephrology.2018; 23(11): 1031. CrossRef
The Global Epidemiology of Diabetes and Kidney Disease
Digsu N. Koye, Dianna J. Magliano, Robert G. Nelson, Meda E. Pavkov
Advances in Chronic Kidney Disease.2018; 25(2): 121. CrossRef
Evaluation of the association between the number of natural teeth and anemia among Korean adults using nationally representative data
Kyungdo Han, Jun‐Beom Park
Journal of Periodontology.2018; 89(10): 1184. CrossRef
Correlation of vascular endothelial function and coagulation factors with renal function and inflammatory factors in patients with diabetic nephropathy
Jie Sun, Caiyan Liu
Experimental and Therapeutic Medicine.2018;[Epub] CrossRef
Cigarette smoking and risk of albuminuria in patients with type 2 diabetes: a systematic review and meta-analysis of observational studies
Haili Xu, Jinliu Suo, Jing Lian
International Urology and Nephrology.2018; 50(5): 911. CrossRef
Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
Diabetes & Metabolism Journal.2018; 42(5): 415. CrossRef
Association between the number of natural teeth and diabetic retinopathy among type 2 diabetes mellitus
Su Jeong Song, Kyungdo Han, Seong-su Lee, Jun-Beom Park
Medicine.2017; 96(47): e8694. CrossRef
Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study
Jong Ho Kim, Sang Soo Kim, In Joo Kim, Bo Hyun Kim, Ja Young Park, Chang Won Lee, Ji Hye Suk, Sun Hae Shin, Sung Pyo Son, Min Chul Kim, Jun Hyeob Ahn, Kwang Jae Lee, Min Jung Kwon, Soon Hee Lee, Jeong Hyun Park
Journal of Diabetes Research.2017; 2017: 1. CrossRef
Determinants of diabetic nephropathy in Ayder Referral Hospital, Northern Ethiopia: A case-control study
Solomon Hintsa, Lamessa Dube, Mebrahtu Abay, Teklit Angesom, Abdulhalik Workicho, Petter Bjornstad
PLOS ONE.2017; 12(4): e0173566. CrossRef
Comparison between Atorvastatin and Rosuvastatin in Renal Function Decline among Patients with Diabetes
Eugene Han, Gyuri Kim, Ji-Yeon Lee, Yong-ho Lee, Beom Seok Kim, Byung-Wan Lee, Bong-Soo Cha, Eun Seok Kang
Endocrinology and Metabolism.2017; 32(2): 274. CrossRef
Association between underweight and tooth loss among Korean adults
In-Seok Song, Kyungdo Han, Jae-Jun Ryu, Jun-Beom Park
Scientific Reports.2017;[Epub] CrossRef
Variability in glycated albumin levels predicts the progression of diabetic nephropathy
Su Bin Park, Sang Soo Kim, In Joo Kim, Yoon Jeong Nam, Kang Hee Ahn, Jong Ho Kim, Yun Kyung Jeon, Bo Hyun Kim, Sang Heon Song, Ihm Soo Kwak, Eun Kyung Lee, Yong Ki Kim
Journal of Diabetes and its Complications.2017; 31(6): 1041. CrossRef
Low serum bilirubin level predicts the development of chronic kidney disease in patients with type 2 diabetes mellitus
Kang Hee Ahn, Sang Soo Kim, Won Jin Kim, Jong Ho Kim, Yun Jeong Nam, Su Bin Park, Yun Kyung Jeon, Bo Hyun Kim, In Joo Kim, Yong Ki Kim
The Korean Journal of Internal Medicine.2017; 32(5): 875. CrossRef
Periodontitis is associated with diabetic retinopathy in non-obese adults
Su Jeong Song, Seong-su Lee, Kyungdo Han, Jun-Beom Park
Endocrine.2017; 56(1): 82. CrossRef
Baseline Cardiovascular Characteristics of Adult Patients with Chronic Kidney Disease from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD)
Hyoungnae Kim, Tae-Hyun Yoo, Kyu Hun Choi, Kook-Hwan Oh, Joongyub Lee, Soo Wan Kim, Tae Hee Kim, Suah Sung, Seung Hyeok Han
Journal of Korean Medical Science.2017; 32(2): 231. CrossRef
Addition of nonalbumin proteinuria to albuminuria improves prediction of type 2 diabetic nephropathy progression
Jong Ho Kim, Seo Young Oh, Eun Heui Kim, Min Jin Lee, Yun Kyung Jeon, Bo Hyun Kim, Jin Mi Kim, Yong Ki Kim, Sang Soo Kim, In Joo Kim
Diabetology & Metabolic Syndrome.2017;[Epub] CrossRef
Smoking and the risk of diabetic nephropathy in patients with type 1 and type 2 diabetes: a meta-analysis of observational studies
Ning Jiang, Feng Huang, Xiurong Zhang
Oncotarget.2017; 8(54): 93209. CrossRef
Treatment of diabetic kidney disease: current and future targets
Mi-Kyung Kim
The Korean Journal of Internal Medicine.2017; 32(4): 622. CrossRef
Analysis and comparison of the cost-effectiveness of statins according to the baseline low-density lipoprotein cholesterol level in Korea
Y. J. Jeong, H. Kim, S. J. Baik, T. M. Kim, S. J. Yang, S.-H. Lee, J.-H. Cho, H. Lee, H. W. Yim, I. Y. Choi, K.-H. Yoon, H.-S. Kim
Journal of Clinical Pharmacy and Therapeutics.2017; 42(3): 292. CrossRef
Mechanistic Insight and Management of Diabetic Nephropathy: Recent Progress and Future Perspective
Rui Xue, Dingkun Gui, Liyang Zheng, Ruonan Zhai, Feng Wang, Niansong Wang
Journal of Diabetes Research.2017; 2017: 1. CrossRef
Nonalbuminuric Renal Insufficiency: Can It Be a Novel Category of Diabetic Nephropathy?
Masami Tanaka, Hiroshi Itoh
Endocrinology and Metabolism.2016; 31(4): 533. CrossRef
Current Challenges in Diabetic Nephropathy: Early Diagnosis and Ways to Improve Outcomes
Sang Soo Kim, Jong Ho Kim, In Joo Kim
Endocrinology and Metabolism.2016; 31(2): 245. CrossRef
Functional mechanisms for diabetic nephropathy-associated genetic variants
Chengxin Gong, Yonghu Xu, Yongfang Fan, Xingzi Liu, Chaopeng Xiong, Luling He, Changle Liu, Shenqiang Rao, Wen Xiao, Lu Ding, Lan Tang, Fangfang Hu, Mengqi Xiong, Mei Yang, Shangdong Liang, Hong Xu
Genes & Genomics.2016; 38(7): 595. CrossRef
Factors Influencing Intention to Receive Examination of Diabetes Complications
Yi-Lin Hsieh, Fang-Hsin Lee, Chien-Liang Chen, Ming-Fong Chang, Pei-Hsuan Han
Asian Nursing Research.2016; 10(4): 289. CrossRef
Associations between the number of natural teeth and renal dysfunction
Hye Min Choi, Kyungdo Han, Yong Gyu Park, Jun-Beom Park
Medicine.2016; 95(34): e4681. CrossRef
Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients
Sang Soo Kim, Sang Heon Song, In Joo Kim, Eun Young Lee, Su Mi Lee, Choon Hee Chung, Ihm Soo Kwak, Eun Kyung Lee, Yong Ki Kim
Journal of Diabetes and its Complications.2016; 30(5): 887. CrossRef
The Association Between Smoking Tobacco After a Diagnosis of Diabetes and the Prevalence of Diabetic Nephropathy in the Korean Male Population
Hyungseon Yeom, Jung Hyun Lee, Hyeon Chang Kim, Il Suh
Journal of Preventive Medicine and Public Health.2016; 49(2): 108. CrossRef
Effects of Small Dense LDL in Diabetic Nephropathy in Females with Type 2 Diabetes Mellitus
Seongyul Ryu, Youngwoo Kim, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Hyun Baek, Ki-Ho Song, Kyung-Jin Yun
Journal of Lipid and Atherosclerosis.2016; 5(1): 11. CrossRef
Translational genomics for human diseases: toward a new era of precision medicine
Yoon Shin Cho, Ki Wha Chung, Nam-Soo Kim
Genes & Genomics.2016; 38(7): 573. CrossRef
Lipoprotein(a) predicts a new onset of chronic kidney disease in people with Type 2 diabetes mellitus
J.‐S. Yun, Y.‐B. Ahn, K.‐H. Song, K.‐D. Yoo, Y.‐M. Park, H.‐W. Kim, S.‐H. Ko
Diabetic Medicine.2016; 33(5): 639. CrossRef
The association between abnormal heart rate variability and new onset of chronic kidney disease in patients with type 2 diabetes: A ten-year follow-up study
Jae-Seung Yun, Yu-Bae Ahn, Ki-Ho Song, Ki-Dong Yoo, Hyung-Wook Kim, Yong-Moon Park, Seung-Hyun Ko
Diabetes Research and Clinical Practice.2015; 108(1): 31. CrossRef
Central obesity is an independent risk factor for microalbuminuria in both the general Korean women and nondiabetic nonhypertensive subpopulation: Association of microalbuminuria and metabolic syndrome from the Korea National Health and Nutrition Examinat
John Hoon Rim, Yong-ho Lee, Bong-Soo Cha, Sang-Guk Lee, Jeong-Ho Kim
Clinica Chimica Acta.2015; 448: 74. CrossRef
Diabetic Kidney Disease: From Epidemiology to Clinical Perspectives
Cheol Whee Park
Diabetes & Metabolism Journal.2014; 38(4): 252. CrossRef

Higher Prevalence and Awareness, but Lower Control Rate of Hypertension in Patients with Diabetes than General Population: The Fifth Korean National Health and Nutrition Examination Survey in 2011: Seung-Hyun Ko, Hyuk-Sang Kwon, Dae Jung Kim, Jae Hyeon Kim, Nan Hee Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Soo Lim, Sung Hee Choi, Kyungdo Han, Yong-Moon Park, Bong-Yun Cha; Diabetes Metab J. 2014;38(1):51-57. Published online February 19, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.1.51

4,399 View
31 Download
28 Web of Science
24 Crossref

Abstract PDF PubReader

Background

We investigated the prevalence, awareness, treatment, and control rate of hypertension in Korean adults with diabetes using nationally representative data.

Methods

Using data of 5,105 adults from the fifth Korea National Health and Nutrition Examination Survey in 2011 (4,389 nondiabetes mellitus [non-DM]), 242 newly diagnosed with DM (new-DM), and 474 previously diagnosed with DM (known-DM), we analyzed the prevalence of hypertension (mean systolic blood pressure ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or use of antihypertensive medication) and control rate of hypertension (blood pressure [BP] <130/80 mm Hg).

Results

The prevalence of hypertension in diabetic adults was 54.6% (44.4% in new-DM and 62.6% in known-DM, P<0.0001 and P<0.0001, respectively) compared with non-DM adults (26.2%). Compared to non-DM, awareness (85.7%, P<0.001) and treatment (97.0%, P=0.020) rates were higher in known-DM, whereas no differences were found between new-DM and non-DM. Control rate among all hypertensive subjects was lower in new-DM (14.9%), compared to non-DM (35.1%, P<0.001) and known-DM (33.3%, P=0.004). Control rate among treated subjects was also lower in new-DM (25.2%), compared to non-DM (68.4%, P<0.0001) and known-DM (39.9%, P<0.0001).

Conclusion

Higher prevalence and low control rate of hypertension in adults with diabetes suggest that stringent efforts are needed to control BP in patients with diabetes, particularly in newly diagnosed diabetic patients.

Citations

Citations to this article as recorded by

Comorbidities of diabetes and hypertension in Vietnam: current burden, trends over time, and correlated factors
Thi Hoang Lan Vu, Thi Tu Quyen Bui, Quoc Bao Tran, Quynh Nga Pham, Duc Truong Lai, Tu Hoang Le, Van Minh Hoang
BMC Public Health.2023;[Epub] CrossRef
Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status
Chan-Hee Jung, Jang Won Son, Shinae Kang, Won Jun Kim, Hun-Sung Kim, Hae Soon Kim, Mihae Seo, Hye-Jung Shin, Seong-Su Lee, Su Jin Jeong, Yongin Cho, Seung Jin Han, Hyang Mi Jang, Mira Rho, Shinbi Lee, Mihyun Koo, Been Yoo, Jung-Wha Moon, Hye Young Lee, Ja
Diabetes & Metabolism Journal.2021; 45(1): 1. CrossRef
Time Trends in Comorbidity and Management of Hypertension and Self-reported Diabetes: A 15-Year Nationwide Longitudinal Study in China
Yixuan Li, Xiaomin Sun, Junxiang Wei, Jing Wu, Youfa Wang
American Journal of Hypertension.2021; 34(8): 810. CrossRef
Impact of Sociodemographic Characteristics, Lifestyle, and Obesity on Coexistence of Diabetes and Hypertension: A Structural Equation Model Analysis amongst Chinese Adults
Wenwen Wu, Jie Diao, Jinru Yang, Donghan Sun, Ying Wang, Ziling Ni, Fen Yang, Xiaodong Tan, Ling Li, Li Li, Lanfranco D Elia
International Journal of Hypertension.2021; 2021: 1. CrossRef
Real-World Effectiveness and Safety of a Single-Pill Combination of Olmesartan/Amlodipine/Hydrochlorothiazide in Korean Patients with Essential Hypertension (RESOLVE): A Large, Observational, Retrospective, Cohort Study
Sung-Ji Park, Si Jae Rhee
Advances in Therapy.2020; 37(8): 3500. CrossRef
Comprehensive Identification of Key Genes Involved in Development of Diabetes Mellitus-Related Atherogenesis Using Weighted Gene Correlation Network Analysis
Qi Huang, Guoxiong Deng, Rongguo Wei, Qiaoye Wang, Donghua Zou, Jinru Wei
Frontiers in Cardiovascular Medicine.2020;[Epub] CrossRef
Risk of hypertension among different metabolic phenotypes: a systematic review and meta-analysis of prospective cohort studies
Atieh Mirzababaei, Hadis Mozaffari, Sakineh Shab-Bidar, Alireza Milajerdi, Kurosh Djafarian
Journal of Human Hypertension.2019; 33(5): 365. CrossRef
Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
Diabetes & Metabolism Journal.2018; 42(5): 415. CrossRef
Evaluation of an association between long sleep duration and periodontal disease among men and women using nationally representative data
Kyungdo Han, Yong-Moon Park, Jun-Beom Park
Gaceta Sanitaria.2018; 32(2): 143. CrossRef
Evaluation of the association between sleep duration and tooth loss among Korean adults: data from the Korean National Health and Nutrition Examination Survey (KNHANES 2012–2014)
Kyungdo Han, Jun-Beom Park
BMJ Open.2018; 8(5): e018383. CrossRef
Association between oral health behavior and periodontal disease among Korean adults
Kyungdo Han, Jun-Beom Park
Medicine.2017; 96(7): e6176. CrossRef
Age threshold for moderate and severe periodontitis among Korean adults without diabetes mellitus, hypertension, metabolic syndrome, and/or obesity
Kyungdo Han, Jun-Beom Park
Medicine.2017; 96(33): e7835. CrossRef
Clinical Course and Risk Factors of Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus in Korea
Jae-Seung Yun, Tae-Seok Lim, Seon-Ah Cha, Yu-Bae Ahn, Ki-Ho Song, Jin A Choi, Jinwoo Kwon, Donghyun Jee, Yang Kyung Cho, Yong-Moon Park, Seung-Hyun Ko
Diabetes & Metabolism Journal.2016; 40(6): 482. CrossRef
Different effect of alcohol consumption on hypertension according to metabolic health status
H K Yang, K Han, Y-M Park, H-S Kwon, K-H Yoon, S-H Lee
Journal of Human Hypertension.2016; 30(10): 591. CrossRef
Differential Association of Metabolic Risk Factors with Open Angle Glaucoma according to Obesity in a Korean Population
Hyun-Ah Kim, Kyungdo Han, Yun-Ah Lee, Jin A Choi, Yong-Moon Park
Scientific Reports.2016;[Epub] CrossRef
Low skeletal muscle mass is associated with non-alcoholic fatty liver disease in Korean adults: the Fifth Korea National Health and Nutrition Examination Survey
Hee Yeon Kim, Chang Wook Kim, Chung-Hwa Park, Jong Young Choi, Kyungdo Han, Anwar T Merchant, Yong-Moon Park
Hepatobiliary & Pancreatic Diseases International.2016; 15(1): 39. CrossRef
Diabetic Cardiovascular Autonomic Neuropathy Predicts Recurrent Cardiovascular Diseases in Patients with Type 2 Diabetes
Seon-Ah Cha, Jae-Seung Yun, Tae-Seok Lim, Kyoungil Min, Ki-Ho Song, Ki-Dong Yoo, Yong-Moon Park, Yu-Bae Ahn, Seung-Hyun Ko, James M Wright
PLOS ONE.2016; 11(10): e0164807. CrossRef
Lipoprotein(a) predicts the development of diabetic retinopathy in people with type 2 diabetes mellitus
Jae-Seung Yun, Tae-Seok Lim, Seon-Ah Cha, Yu-Bae Ahn, Ki-Ho Song, Jin A. Choi, Jinwoo Kwon, Donghyun Jee, Yang Kyung Cho, Yong-Moon Park, Seung-Hyun Ko
Journal of Clinical Lipidology.2016; 10(2): 426. CrossRef
Elevated lipoprotein(a) levels predict cardiovascular disease in type 2 diabetes mellitus: a 10-year prospective cohort study
Tae-Seok Lim, Jae-Seung Yun, Seon-Ah Cha, Ki-Ho Song, Ki-Dong Yoo, Yu-Bae Ahn, Yong-Moon Park, Seung-Hyun Ko
The Korean Journal of Internal Medicine.2016; 31(6): 1110. CrossRef
The association of incident hypertension with metabolic health and obesity status: definition of metabolic health does not matter
Yu Mi Kang, Chang Hee Jung, Jung Eun Jang, Jenie Yoonoo Hwang, Eun Hee Kim, Joong‐Yeol Park, Hong‐Kyu Kim, Woo Je Lee
Clinical Endocrinology.2016; 85(2): 207. CrossRef
The association between abnormal heart rate variability and new onset of chronic kidney disease in patients with type 2 diabetes: A ten-year follow-up study
Jae-Seung Yun, Yu-Bae Ahn, Ki-Ho Song, Ki-Dong Yoo, Hyung-Wook Kim, Yong-Moon Park, Seung-Hyun Ko
Diabetes Research and Clinical Practice.2015; 108(1): 31. CrossRef
Obesity as a Potential Risk Factor for Blepharoptosis: The Korea National Health and Nutrition Examination Survey 2008-2010
Ji-Sun Paik, Su-Kyung Jung, Kyung-Do Han, Sang-Duck Kim, Yong-Moon Park, Suk-Woo Yang, Michele Madigan
PLOS ONE.2015; 10(7): e0131427. CrossRef
Cost-effectiveness analysis of low density lipoprotein cholesterol-lowering therapy in hypertensive patients with type 2 diabetes in Korea: single-pill regimen (amlodipine/atorvastatin) versus double-pill regimen (amlodipine+atorvastatin)
Ji-Hyun Park, Yong-Ho Lee, Su-Kyoung Ko, Bong-Soo Cha
Epidemiology and Health.2015; 37: e2015010. CrossRef
Early Renal Abnormalities as an Indicator of Cardiovascular Risk in Type 2 Diabetes
Francesca Viazzi, Barbara Bonino, Elena Ratto, Salvatore De Cosmo, Roberto Pontremoli
High Blood Pressure & Cardiovascular Prevention.2014; 21(4): 257. CrossRef

Prevalence, Awareness, and Management of Obesity in Korea: Data from the Korea National Health and Nutrition Examination Survey (1998-2011): Chul Sik Kim, Seung-Hyun Ko, Hyuk-Sang Kwon, Nan Hee Kim, Jae Hyeon Kim, Soo Lim, Sung Hee Choi, Kee-Ho Song, Jong Chul Won, Dae Jung Kim, Bong-Yun Cha; Diabetes Metab J. 2014;38(1):35-43. Published online February 19, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.1.35

5,750 View
34 Download
78 Web of Science
84 Crossref

Abstract PDF PubReader

Background

Obesity is a risk factor for diabetes and several cardiovascular diseases. This study was to investigate the trends in the prevalence, awareness, and management status of obesity among the Korean population for recent 13 years.

Methods

The prevalence, subjective awareness, and management of obesity were investigated in adults aged ≥19 years by using the data from the Korea National Health and Nutrition Examination Surveys (KNHANES) 1998 to 2011.

Results

The number of participants was 8,117, 5,826, 5,500, 3,025, 6,756, 7,506, 6,255, and 6,155 in the KNHANES in years 1998, 2001, 2005, 2007, 2008, 2009, 2010, and 2011, respectively. The prevalence of obesity was 26.9%, 29.2%, 32.9%, 32.5%, 32.0%, 32.6%, 32.0%, and 32.0% in 1998, 2001, 2005, 2007, 2008, 2009, 2010, and 2011, respectively, while the overall prevalence of obesity and abdominal obesity increased by 1.19-fold and 1.24-fold respectively in 2011 compared against 2001. In general, a gradual increase in the prevalence of severe obesity has been observed as years go by. Furthermore, trends of improvements in obesity awareness and management rates were visible over the period of surveys.

Conclusion

Although the management status of obesity has improved during the recent years, more effective strategy to control obesity is needed.

Citations

Citations to this article as recorded by

Mediators of the Effect of Obesity on Stroke and Heart Disease Risk: Decomposing Direct and Indirect Effects
Yongho Jee, Mikyung Ryu, In Sun Ryou, Joung Hwan Back, Sung-il Cho, Seung Sik Hwang
Journal of Epidemiology.2023; 33(10): 514. CrossRef
Hormonal Gut–Brain Signaling for the Treatment of Obesity
Eun Roh, Kyung Mook Choi
International Journal of Molecular Sciences.2023; 24(4): 3384. CrossRef
Weight-Adjusted-Waist Index Predicts Newly Diagnosed Diabetes in Chinese Rural Adults
Shasha Yu, Bo Wang, Xiaofan Guo, Guangxiao Li, Hongmei Yang, Yingxian Sun
Journal of Clinical Medicine.2023; 12(4): 1620. CrossRef
Impact of abdominal obesity on the risk of glioma development in patients with diabetes: A nationwide population-based cohort study in Korea
Hyunji Sang, Yun Kyung Cho, Kyungdo Han, Eun Hee Koh, Sandar Tin Tin
PLOS ONE.2023; 18(3): e0283023. CrossRef
Association of Obesity and Incidence of Third, Fourth, and Sixth Cranial Nerve Palsies
Daye Diana Choi, Kyungdo Han, Kyung-Ah Park, Sei Yeul Oh
American Journal of Ophthalmology.2022; 235: 258. CrossRef
Chronological trends in patients undergoing cholecystectomy in Korea: a nationwide health insurance claims study
Chul Hyo Jeon, Jinwook Hong, Jaehun Jung, Jong Youn Moon, Ho Seok Seo
Annals of Surgical Treatment and Research.2022; 102(4): 205. CrossRef
Non-alcoholic fatty liver disease and sarcopenia is associated with the risk of albuminuria independent of insulin resistance, and obesity
Eugene Han, Mi Kyung Kim, Seung-Soon Im, Byoung Kuk Jang, Hye Soon Kim
Journal of Diabetes and its Complications.2022; 36(8): 108253. CrossRef
Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status
Chan-Hee Jung, Jang Won Son, Shinae Kang, Won Jun Kim, Hun-Sung Kim, Hae Soon Kim, Mihae Seo, Hye-Jung Shin, Seong-Su Lee, Su Jin Jeong, Yongin Cho, Seung Jin Han, Hyang Mi Jang, Mira Rho, Shinbi Lee, Mihyun Koo, Been Yoo, Jung-Wha Moon, Hye Young Lee, Ja
Diabetes & Metabolism Journal.2021; 45(1): 1. CrossRef
Trends and Inequalities in Overall and Abdominal Obesity by Sociodemographic Factors in Korean Adults, 1998–2018
Ha-Jin Jang, Hannah Oh
International Journal of Environmental Research and Public Health.2021; 18(8): 4162. CrossRef
Trends of age‐related non‐communicable diseases in people living with HIV and comparison with uninfected controls: A nationwide population‐based study in South Korea
Jung Ho Kim, Juhwan Noh, Woojin Kim, Hye Seong, Jun Hyoung Kim, Woon Ji Lee, YaeJee Baek, JongHoon Hyun, Yujin Sohn, Yunsuk Cho, Moo Hyun Kim, SangMin Ahn, Yongseop Lee, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Joon‐Sup Yeom, Changsoo Kim, Jun Yong Choi
HIV Medicine.2021; 22(9): 824. CrossRef
Comparative Observation of Body Mass Index among Adults in Korea and Japan
Myeong-Jin Lee, Young-Hoon Chae, Won-Chang Lee, Young Hwan Kwon
The Korean Journal of Aerospace and Environmental Medicine.2021; 31(2): 45. CrossRef
Effect of Bariatric Surgery on Urinary Incontinence in Obese Women: A Meta-analysis and Systematic Review
Jindong Zhang, Liang Gao, Maoyu Liu, Chuan Liu
Female Pelvic Medicine & Reconstructive Surgery.2020; 26(3): 207. CrossRef
Perceptions, Attitudes, Behaviors, and Barriers to Effective Obesity Care in South Korea: Results from the ACTION-IO Study
Soo Lim, Bumjo Oh, Seung-Hwan Lee, Yang-Hyun Kim, Yousun Ha, Jae-Heon Kang
Journal of Obesity & Metabolic Syndrome.2020; 29(2): 133. CrossRef
The Prevalence and Incidence of Insomnia in Korea during 2005 to 2013
Seockhoon Chung, Seung Woo Cho, Min-Woo Jo, Soyoung Youn, Jiho Lee, Chang Sun Sim
Psychiatry Investigation.2020; 17(6): 533. CrossRef
Relationship between sleep and obesity among U.S. and South Korean college students
Jaesin Sa, Siyoung Choe, Beom-young Cho, Jean-Philippe Chaput, Gyurin Kim, Chae-Hee Park, Joon Chung, Yoojin Choi, Beatrice Nelson, Yongkyu Kim
BMC Public Health.2020;[Epub] CrossRef
Comprehensive Identification of Key Genes Involved in Development of Diabetes Mellitus-Related Atherogenesis Using Weighted Gene Correlation Network Analysis
Qi Huang, Guoxiong Deng, Rongguo Wei, Qiaoye Wang, Donghua Zou, Jinru Wei
Frontiers in Cardiovascular Medicine.2020;[Epub] CrossRef
Self-perceptions of body weight status according to age-groups among Korean women: A nationwide population-based survey
Boyoung Park, Ha Na Cho, Eunji Choi, Da Hea Seo, Sue Kim, Yeong-Ran Park, Kui Son Choi, Yumie Rhee, Yongjoo Kim
PLOS ONE.2019; 14(1): e0210486. CrossRef
Big data and analysis of risk factors for gallbladder disease in the young generation of Korea
Hyung Sun Kim, Seong Kyung Cho, Chang Soo Kim, Joon Seong Park, David Meyre
PLOS ONE.2019; 14(2): e0211480. CrossRef
Ecological Factors Affecting Obesity Among Middle School Students in South Korea
Suhee Kim, Gwang Suk Kim
Journal of School Health.2019; 89(3): 181. CrossRef
Prevalence and Perception of Obesity Among Sub-Saharan Africans in Korea
Ijeoma Alaeze, Maxine Newell, Mieun Yun, Sungsoo Chun
Journal of Immigrant and Minority Health.2019; 21(3): 555. CrossRef
Body weight perception, disordered weight control behaviors, and depressive symptoms among Korean adults: The Korea National Health and Nutrition Examination Survey 2014
Yongjoo Kim, S. Bryn Austin, S. V. Subramanian, Ichiro Kawachi, Chung-Ying Lin
PLOS ONE.2018; 13(6): e0198841. CrossRef
Trends and Cut-Point Changes in Obesity Parameters by Age Groups Considering Metabolic Syndrome
Hyung Jun Park, Young Ho Hong, Yun Jung Cho, Ji Eun Lee, Jae Moon Yun, Hyuktae Kwon, Sang Hyuck Kim
Journal of Korean Medical Science.2018;[Epub] CrossRef
Fifty Years of Compassionate Care and Harmonious Collaboration of the Korean Diabetes Association: The 50th Anniversary of Korean Diabetes Association
Jong Chul Won, Eun-Jung Rhee, Hyung Joon Yoo
Diabetes & Metabolism Journal.2018; 42(6): 475. CrossRef
The Cardiometabolic Burden of Self-Perceived Obesity: A Multilevel Analysis of a Nationally Representative Sample of Korean Adults
Yongjoo Kim, S. Bryn Austin, S V Subramanian, Ichiro Kawachi
Scientific Reports.2018;[Epub] CrossRef
Characteristics of Dapagliflozin Responders: A Longitudinal, Prospective, Nationwide Dapagliflozin Surveillance Study in Korea
Eugene Han, Ari Kim, Sung Jae Lee, Je-Yon Kim, Jae Hyeon Kim, Woo Je Lee, Byung-Wan Lee
Diabetes Therapy.2018; 9(4): 1689. CrossRef
A novel adiposity index as an integrated predictor of cardiometabolic disease morbidity and mortality
Yousung Park, Nam Hoon Kim, Tae Yeon Kwon, Sin Gon Kim
Scientific Reports.2018;[Epub] CrossRef
The Effects of Weight Control Behaviors among Korean Obese Adults
Li-Ly Kang, Ha-Nui Kim, Young-Ah Jung, Hwan-Sik Hwang, Hoon-Ki Park, Kye-Yeung Park
Korean Journal of Family Medicine.2018; 39(4): 247. CrossRef
The efficacy and safety of Hanslim for obese patients
Seunghoon Lee, Hyeonhoon Lee, Yeeun Cho, Jihye Kim, Jung Won Kang, Byung-Kwan Seo, Yong-Hyeon Baek, Jae-Dong Lee
Medicine.2018; 97(38): e12440. CrossRef
Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
Diabetes & Metabolism Journal.2018; 42(5): 415. CrossRef
Importance of Active Participation in Obesity Management Through Mobile Health Care Programs: Substudy of a Randomized Controlled Trial
Bumjo Oh, Ga-Hye Yi, Min Kyu Han, Jong Seung Kim, Chang Hee Lee, Belong Cho, Hee Cheol Kang
JMIR mHealth and uHealth.2018; 6(1): e2. CrossRef
Independent Association of Serum Aldosterone Level with Metabolic Syndrome and Insulin Resistance in Korean Adults
Se Hee Min, Se-Hong Kim, In-Kyung Jeong, Ho Chan Cho, Jin-Ok Jeong, Ju-Hee Lee, Hyun-Jae Kang, Hyo Soo Kim, Kyong Soo Park, Soo Lim
Korean Circulation Journal.2018; 48(3): 198. CrossRef
The effects of abdominal interferential current therapy on waist circumference and visceral fat distance in obese women
Young-Han Park, Jung-Ho Lee
Journal of Physical Therapy Science.2017; 29(9): 1680. CrossRef
Sex differences in prevalence and risk factors of asymptomatic cholelithiasis in Korean health screening examinee
Sung Bum Kim, Kook Hyun Kim, Tae Nyeun Kim, Jun Heo, Min Kyu Jung, Chang Min Cho, Yoon Suk Lee, Kwang Bum Cho, Dong Wook Lee, Ji Min Han, Ho Gak Kim, Hyun Soo Kim
Medicine.2017; 96(13): e6477. CrossRef
Endoscopic Approach for Major Complications of Bariatric Surgery
Moon Kyung Joo
Clinical Endoscopy.2017; 50(1): 31. CrossRef
Effectiveness of a Smartphone Application for the Management of Metabolic Syndrome Components Focusing on Weight Loss: A Preliminary Study
Tatiana Toro-Ramos, Dong-Hwa Lee, Youngin Kim, Andreas Michaelides, Tae Jung Oh, Kyoung Min Kim, Hak Chul Jang, Soo Lim
Metabolic Syndrome and Related Disorders.2017; 15(9): 465. CrossRef
Differential association between sarcopenia and metabolic phenotype in Korean young and older adults with and without obesity
You‐Cheol Hwang, In‐Jin Cho, In‐Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung
Obesity.2017; 25(1): 244. CrossRef
Overweightness, obesity and arterial stiffness in healthy subjects: a systematic review and meta-analysis of literature studies
Ping Li, Lei Wang, Chao Liu
Postgraduate Medicine.2017; 129(2): 224. CrossRef
Effectiveness and safety of exenatide in Korean patients with type 2 diabetes inadequately controlled with oral hypoglycemic agents: an observational study in a real clinical practice
You-Cheol Hwang, Ari Kim, Euna Jo, Yeoree Yang, Jae-Hyoung Cho, Byung-Wan Lee
BMC Endocrine Disorders.2017;[Epub] CrossRef
Exenatide versus Insulin Lispro Added to Basal Insulin in a Subgroup of Korean Patients with Type 2 Diabetes Mellitus
Kun-Ho Yoon, Elise Hardy, Jenny Han
Diabetes & Metabolism Journal.2017; 41(1): 69. CrossRef
Serum Chemerin Levels are Associated with Visceral Adiposity, Independent of Waist Circumference, in Newly Diagnosed Type 2 Diabetic Subjects
Dae Young Cheon, Jun Goo Kang, Seong Jin Lee, Sung Hee Ihm, Eun Jig Lee, Moon Gi Choi, Hyung Joon Yoo, Chul Sik Kim
Yonsei Medical Journal.2017; 58(2): 319. CrossRef
Prevalence and severity of coronary artery calcification based on the epidemiologic pattern: A propensity matched comparison of asymptomatic Korean and Chinese adults
Donghee Han, Yang Gao, Bríain ó Hartaigh, Heidi Gransar, Ji Hyun Lee, Asim Rizvi, Su-Yeon Choi, Eun Ju Chun, Jidong Sung, Hae-Won Han, Sung Hak Park, James K. Min, Bin Lu, Hyuk-Jae Chang
International Journal of Cardiology.2017; 230: 353. CrossRef
Improvement of voiding characteristics in morbidly obese women after bariatric surgery: A single-center study with a 1-year follow-up
Jae Heon Kim, Hwa Yeon Sun, Hyun Young Lee, Min Ju Soh, Suyeon Park, Yong Jin Kim, Yun Seob Song
Surgery for Obesity and Related Diseases.2017; 13(5): 836. CrossRef
The association of body mass index with outcomes and targeted temperature management practice in cardiac arrest survivors
Yong Hun Jung, Byung Kook Lee, Dong Hun Lee, Sung Min Lee, Yong Soo Cho, Kyung Woon Jeung
The American Journal of Emergency Medicine.2017; 35(2): 268. CrossRef
Breast milk fatty acid composition and fatty acid intake of lactating mothers in South Korea
Hyesook Kim, Sujeong Kang, Byung-Moon Jung, Hyunju Yi, Ji A. Jung, Namsoo Chang
British Journal of Nutrition.2017; 117(4): 556. CrossRef
Central Obesity as a Risk Factor for Non-Erosive Reflux Disease
Ki Ju Kim, Ban Seok Lee
Yonsei Medical Journal.2017; 58(4): 743. CrossRef
Prevalence of abdominal obesity among Chinese adults in 2011
Pei Du, Hui-Jun Wang, Bing Zhang, Su-Fen Qi, Ying-Jun Mi, Dian-Wu Liu, Qing-Bao Tian
Journal of Epidemiology.2017; 27(6): 282. CrossRef
Association Between Obesity and Chronic Kidney Disease, Defined by Both Glomerular Filtration Rate and Albuminuria, in Korean Adults
Yoon Ji Kim, Seun Deuk Hwang, Tae Jung Oh, Kyoung Min Kim, Hak Chul Jang, Heejin Kimm, Hyeon Chang Kim, Sun Ha Jee, Soo Lim
Metabolic Syndrome and Related Disorders.2017; 15(8): 416. CrossRef
Long-term Oncologic Outcomes of Obesity after Laparoscopic Surgery for Colorectal Cancer in Asian Patients
Jung Hak Kwak, Ji Won Park, Byung Kwan Park, Eon Chul Han, Jeong-Ki Kim, Yoon-Hye Kwon, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
The Journal of Minimally Invasive Surgery.2016; 19(4): 148. CrossRef
Effects of Activity-Based Personalized Nutrition Education on Dietary Behaviors and Blood Parameters in Middle-Aged and Older Type 2 Diabetes Korean Outpatients
Seung Hye Yang, Hye-Kyung Chung, Seung-Min Lee
Clinical Nutrition Research.2016; 5(4): 237. CrossRef
Mediterranean diet and mortality risk in metabolically healthy obese and metabolically unhealthy obese phenotypes
Y-M Park, S E Steck, T T Fung, J Zhang, L J Hazlett, K Han, A T Merchant
International Journal of Obesity.2016; 40(10): 1541. CrossRef
A genetic variant in GLP1R is associated with response to DPP-4 inhibitors in patients with type 2 diabetes
Eugene Han, Hye Sun Park, Obin Kwon, Eun Yeong Choe, Hye Jin Wang, Yong-ho Lee, Sang-Hak Lee, Chul Hoon Kim, Lee-Kyung Kim, Soo Heon Kwak, Kyong Soo Park, Chul Sik Kim, Eun Seok Kang
Medicine.2016; 95(44): e5155. CrossRef
Life-threatening late complication after laparoscopic adjustable gastric banding: two cases of gastric necrosis
Eun Young Kim, Yong Jin Kim
Surgery for Obesity and Related Diseases.2016; 12(1): e5. CrossRef
Does bariatric surgery really prevent deterioration of renal function?
Eun Young Kim, Yong Jin Kim
Surgery for Obesity and Related Diseases.2016; 12(4): 856. CrossRef
Are We in the Same Risk of Diabetes Mellitus? Gender- and Age-Specific Epidemiology of Diabetes in 2001 to 2014 in the Korean Population
Bo Kyung Koo, Min Kyong Moon
Diabetes & Metabolism Journal.2016; 40(3): 175. CrossRef
Comparison of Vildagliptin and Pioglitazone in Korean Patients with Type 2 Diabetes Inadequately Controlled with Metformin
Jong Ho Kim, Sang Soo Kim, Hong Sun Baek, In Kyu Lee, Dong Jin Chung, Ho Sang Sohn, Hak Yeon Bae, Mi Kyung Kim, Jeong Hyun Park, Young Sik Choi, Young Il Kim, Jong Ryeal Hahm, Chang Won Lee, Sung Rae Jo, Mi Kyung Park, Kwang Jae Lee, In Joo Kim
Diabetes & Metabolism Journal.2016; 40(3): 230. CrossRef
Different effect of alcohol consumption on hypertension according to metabolic health status
H K Yang, K Han, Y-M Park, H-S Kwon, K-H Yoon, S-H Lee
Journal of Human Hypertension.2016; 30(10): 591. CrossRef
Waist–hip ratio and 1-year clinical outcome in patients with non-ST-elevation myocardial infarctions
Hye Won Lee, Taek Jong Hong, Ju Young Hong, Jong Hyun Choi, Bo Won Kim, Jinhee Ahn, Jin Sup Park, Jun-Hyok Oh, Jung Hyun Choi, Han Cheol Lee, Kwang Soo Cha
Coronary Artery Disease.2016; 27(5): 357. CrossRef
Klinefelter Syndrome and Metabolic Disorder
Ji Cheol Bae
Endocrinology and Metabolism.2016; 31(4): 535. CrossRef
Difference between old and young adults in contribution of β‐cell function and sarcopenia in developing diabetes mellitus
Bo Kyung Koo, Eun Roh, Ye Seul Yang, Min Kyong Moon
Journal of Diabetes Investigation.2016; 7(2): 233. CrossRef
Diabetic Cardiovascular Autonomic Neuropathy Predicts Recurrent Cardiovascular Diseases in Patients with Type 2 Diabetes
Seon-Ah Cha, Jae-Seung Yun, Tae-Seok Lim, Kyoungil Min, Ki-Ho Song, Ki-Dong Yoo, Yong-Moon Park, Yu-Bae Ahn, Seung-Hyun Ko, James M Wright
PLOS ONE.2016; 11(10): e0164807. CrossRef
Obesity and Hyperglycemia in Korean Men with Klinefelter Syndrome: The Korean Endocrine Society Registry
Seung Jin Han, Kyung-Soo Kim, Wonjin Kim, Jung Hee Kim, Yong-ho Lee, Ji Sun Nam, Ji A Seo, Bu Kyung Kim, Jihyun Lee, Jin Ook Chung, Min-Hee Kim, Tae-Seo Sohn, Han Seok Choi, Seong Bin Hong, Yoon-Sok Chung
Endocrinology and Metabolism.2016; 31(4): 598. CrossRef
Obesity in Korean Men: Results from the Fourth through Sixth Korean National Health and Nutrition Examination Surveys (2007~2014)
Yeon Won Park, Kwi Bok Choi, Soon Ki Kim, Dong-Gi Lee, Jun Ho Lee
The World Journal of Men's Health.2016; 34(2): 129. CrossRef
Cardiovascular Risk Factors in Gastric Cancer Patients Decrease 1 Year After Gastrectomy
Tae Kyung Ha, Youn Kyoung Seo, Bo Kyeong Kang, Jinho Shin, Eunyoung Ha
Obesity Surgery.2016; 26(10): 2340. CrossRef
Risk of the Development of Diabetes and Cardiovascular Disease in Metabolically Healthy Obese People
Nan Hee Kim, Ji A Seo, Hyunjoo Cho, Ji Hye Seo, Ji Hee Yu, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Chol Shin, Nam Han Cho
Medicine.2016; 95(15): e3384. CrossRef
Self‐perceived health versus actual cardiovascular disease risks
Young Ko, Sunjoo Boo
Japan Journal of Nursing Science.2016; 13(1): 65. CrossRef
Aster spathulifolius Maxim extract reduces body weight and fat mass in obese humans
In-Jin Cho, Se Young Choung, You-Cheol Hwang, Kyu Jeung Ahn, Ho Yeon Chung, In-Kyung Jeong
Nutrition Research.2016; 36(7): 671. CrossRef
Acceptability and Feasibility of a Smartphone Application for 5th, 6th Grade Elementary Students to Prevent Childhood Obesity; a Qualitative Study
Ji-Hye Jung, Young-Gyu Cho, Da-Ye Ji, Jae-Heon Kang
Korean Journal of Health Promotion.2016; 16(4): 251. CrossRef
Trends in Diabetes Incidence in the Last Decade Based on Korean National Health Insurance Claims Data
Sun Ok Song, Yong-ho Lee, Dong Wook Kim, Young Duk Song, Joo Young Nam, Kyoung Hye Park, Dae Jung Kim, Seok Won Park, Hyun Chul Lee, Byung-Wan Lee
Endocrinology and Metabolism.2016; 31(2): 292. CrossRef
Long-term Oncologic Outcomes of Obesity after Laparoscopic Surgery for Colorectal Cancer in Asian Patients
Se-Jin Baek
The Journal of Minimally Invasive Surgery.2016; 19(4): 117. CrossRef
School- and Individual-level Predictors of Weight Status Misperception among Korean Adolescents: A National Online Survey
Yongjoo Kim, Ichiro Kawachi, Martin J Tovée
PLOS ONE.2016; 11(5): e0154826. CrossRef
Differential Association of Metabolic Risk Factors with Open Angle Glaucoma according to Obesity in a Korean Population
Hyun-Ah Kim, Kyungdo Han, Yun-Ah Lee, Jin A Choi, Yong-Moon Park
Scientific Reports.2016;[Epub] CrossRef
New and emerging drugs for the treatment of obesity
Eun Roh, Min Seon Kim
Journal of the Korean Medical Association.2015; 58(5): 452. CrossRef
Recent Advances for Anti-Obesity Agents
Chul Sik Kim
The Journal of Korean Diabetes.2015; 16(4): 260. CrossRef
Prognostic influence of body mass index and body weight gain during adjuvant FOLFOX chemotherapy in Korean colorectal cancer patients
Dae-Won Lee, Sae-Won Han, Yongjun Cha, Kyung-Hun Lee, Tae-Yong Kim, Do-Youn Oh, Seock-Ah Im, Yung-Jue Bang, Ji Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Gyeong Hoon Kang, Kyu Joo Park, Tae-You Kim
BMC Cancer.2015;[Epub] CrossRef
Plasma Adiponectin Levels in Elderly Patients with Prediabetes
Si Eun Kong, Yea Eun Kang, Kyong Hye Joung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
Endocrinology and Metabolism.2015; 30(3): 326. CrossRef
Identifying subgroups of obesity using the product of triglycerides and glucose: the Korea National Health and Nutrition Examination Survey, 2008–2010
Seung‐Hwan Lee, Kyungdo Han, Hae Kyung Yang, Mee Kyoung Kim, Kun‐Ho Yoon, Hyuk‐Sang Kwon, Yong‐Moon Park
Clinical Endocrinology.2015; 82(2): 213. CrossRef
Can increased visceral adiposity without body weight changes accelerate carotid atherosclerosis in South Korean participants with type 2 diabetes?
Chul Sik Kim, Soo-Kyung Kim, Maria Rosario G. Araneta, Eun Jig Lee, Elizabeth Barrett-Connor, Kab Bum Huh
Journal of Diabetes and its Complications.2015; 29(8): 1085. CrossRef
A novel criterion for identifying metabolically obese but normal weight individuals using the product of triglycerides and glucose
S-H Lee, K Han, H K Yang, H-S Kim, J-H Cho, H-S Kwon, Y-M Park, B-Y Cha, K-H Yoon
Nutrition & Diabetes.2015; 5(4): e149. CrossRef
The Role of Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes: Understanding How Data Can Inform Clinical Practice in Korea
Seungjoon Oh, Suk Chon, Kyu Jeong Ahn, In-Kyung Jeong, Byung-Joon Kim, Jun Goo Kang
Diabetes & Metabolism Journal.2015; 39(3): 177. CrossRef
Quantification of Visceral Fat Using Dual-Energy X-Ray Absorptiometry and Its Reliability According to the Amount of Visceral Fat in Korean Adults
Yong Jun Choi, Young Kyun Seo, Eun Ju Lee, Yoon-Sok Chung
Journal of Clinical Densitometry.2015; 18(2): 192. CrossRef
Ambient Temperature and Prevalence of Obesity: A Nationwide Population-Based Study in Korea
Hae Kyung Yang, Kyungdo Han, Jae-Hyoung Cho, Kun-Ho Yoon, Bong-Yun Cha, Seung-Hwan Lee, David Meyre
PLOS ONE.2015; 10(11): e0141724. CrossRef
Lower serum zinc levels are associated with unhealthy metabolic status in normal-weight adults: The 2010 Korea National Health and Nutrition Examination Survey
H.K. Yang, S.H. Lee, K. Han, B. Kang, S.Y. Lee, K.H. Yoon, H.S. Kwon, Y.M. Park
Diabetes & Metabolism.2015; 41(4): 282. CrossRef
The Effectiveness of Mobile Phone-Based Care for Weight Control in Metabolic Syndrome Patients: Randomized Controlled Trial
Bumjo Oh, Belong Cho, Min Kyu Han, Hochun Choi, Mi Na Lee, Hee-Cheol Kang, Chang Hee Lee, Heeseong Yun, Youngho Kim
JMIR mHealth and uHealth.2015; 3(3): e83. CrossRef
Current Information and Asian Perspectives on Long-Chain Polyunsaturated Fatty Acids in Pregnancy, Lactation, and Infancy: Systematic Review and Practice Recommendations from an Early Nutrition Academy Workshop
Berthold Koletzko, Christopher C.M. Boey, Cristina Campoy, Susan E. Carlson, Namsoo Chang, Maria Antonia Guillermo-Tuazon, Sadhana Joshi, Christine Prell, Seng Hock Quak, Damayanti Rusli Sjarif, Yixiang Su, Sarayut Supapannachart, Yuichiro Yamashiro, Sask
Annals of Nutrition and Metabolism.2014; 65(1): 49. CrossRef

Review

Current Status of Diabetic Peripheral Neuropathy in Korea: Report of a Hospital-Based Study of Type 2 Diabetic Patients in Korea by the Diabetic Neuropathy Study Group of the Korean Diabetes Association: Jong Chul Won, Sang Soo Kim, Kyung Soo Ko, Bong-Yun Cha; Diabetes Metab J. 2014;38(1):25-31. Published online February 19, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.1.25

4,341 View
56 Download
29 Web of Science
27 Crossref

Abstract PDF PubReader

Diabetic peripheral neuropathy (DPN) is the most common complication associated with diabetes. DPN can present as a loss of sensation, may lead to neuropathic ulcers, and is a leading cause of amputation. Reported estimates of the prevalence of DPN vary due to differences in study populations and diagnostic criteria. Furthermore, the epidemiology and clinical characteristics of DPN in Korean patients with type 2 diabetes mellitus (T2DM) are not as well understood as those of other complications of diabetes such as retinal and renal disease. Recently, the Diabetic Neuropathy Study Group of the Korean Diabetes Association (KDA) conducted a study investigating the impact of DPN on disease burden and quality of life in patients with T2DM and has published some data that are representative of the nation. This review investigated the prevalence and associated clinical implications of DPN in Korean patients with diabetes based on the KDA study.

Citations

Citations to this article as recorded by

Shear wave elastography of tibial nerve in patients with diabetic peripheral neuropathy—A cross-sectional study
Dhiri Ranjan Pradhan, Sudhir Saxena, Ravi Kant, Mirtunjai Kumar, Sonal Saran
Skeletal Radiology.2024; 53(3): 547. CrossRef
Diabetic peripheral neuropathy: age-stratified glycemic control
Chi-Sheng Wang, Yen-Wei Pai, Ching-Heng Lin, I-Te Lee, Hsiao-Hui Chen, Ming-Hong Chang
Frontiers in Endocrinology.2024;[Epub] CrossRef
Association of Sensory Nerve Action Potential Amplitude and Velocity With Type 2 Diabetic Peripheral Neuropathy
Anwar H Siddiqui, Nazia Tauheed, Hamid Ashraf, Jamal Ahmad
Cureus.2023;[Epub] CrossRef
A review on extraction, purification, structural characteristics and bioactivities of polysaccharides from Polygonatum odoratum (Mill.) Druce
Xin-Yan Zong, De-Chang Xu, Jun-Yi Yin, Shao-Ping Nie, Ming-Yong Xie
Bioactive Carbohydrates and Dietary Fibre.2022; 27: 100284. CrossRef
Development and characterisation of a rat model that exhibits both metabolic dysfunction and neurodegeneration seen in type 2 diabetes
Katherine Southam, Chantal de Sousa, Abraham Daniel, Bruce V. Taylor, Lisa Foa, Dino Premilovac
The Journal of Physiology.2022; 600(7): 1611. CrossRef
Renal impairment is one of appropriate predictors of future diabetic peripheral neuropathy: a hospital-based 6-year follow-up study
Chi-Sheng Wang, Yen-Wei Pai, Ching-Heng Lin, I-Te Lee, Ming-Hong Chang
Scientific Reports.2022;[Epub] CrossRef
Pathogenesis and Treatment of Diabetic Peripheral Neuropathy
Seon Mee Kang
The Journal of Korean Diabetes.2022; 23(4): 222. CrossRef
Compound XiongShao Capsule ameliorates streptozotocin-induced diabetic peripheral neuropathy in rats via inhibiting apoptosis, oxidative - nitrosative stress and advanced glycation end products
Mei-xiang Yu, Bo Lei, Xin Song, Yong-mei Huang, Xiao-qin Ma, Chen-xia Hao, Wan-hua Yang, Man-li Pan
Journal of Ethnopharmacology.2021; 268: 113560. CrossRef
Etiology, diagnosis, complications, and treatments of diabetic foot
Dong-Kyo Seo
Journal of the Korean Medical Association.2021; 64(8): 523. CrossRef
A nationwide study of patients with monoclonal gammopathy of undetermined significance with a 10-year follow-up in South Korea
Ka-Won Kang, Ji Eun Song, Byung-Hyun Lee, Min Ji Jeon, Eun Sang Yu, Dae Sik Kim, Se Ryeon Lee, Hwa Jung Sung, Chul Won Choi, Yong Park, Byung Soo Kim
Scientific Reports.2021;[Epub] CrossRef
Acupuncture for diabetic peripheral neuropathy: study protocol for a randomized, placebo-controlled trial
Haiping Deng, Yu Shu, Peiran Lv, Ling Zhao, Ke Cheng, Tingting Zhang, Yi Song, Hua Yang, Hong Tang, Jian Pei, Xueyong Shen
Trials.2020;[Epub] CrossRef
Identify the Key Active Ingredients and Pharmacological Mechanisms of Compound XiongShao Capsule in Treating Diabetic Peripheral Neuropathy by Network Pharmacology Approach
Meixiang Yu, Xin Song, Wanhua Yang, Ziwei Li, Xiaoqin Ma, Chenxia Hao
Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1. CrossRef
Deep phenotyping neuropathy: An underestimated complication in patients with pre-diabetes and type 2 diabetes associated with albuminuria
Stefan Kopf, Jan B. Groener, Zoltan Kender, Thomas Fleming, Sandra Bischoff, Johann Jende, Carsten Schumann, Stefan Ries, Martin Bendszus, Sigrid Schuh-Hofer, Rolf-Detlef Treede, Peter P. Nawroth
Diabetes Research and Clinical Practice.2018; 146: 191. CrossRef
Role of neopterin as a biochemical marker for peripheral neuropathy in pediatric patients with type 1 diabetes: Relation to nerve conduction studies
Nancy Samir Elbarbary, Eman Abdel Rahman Ismail, Rana Ahmed El-Hilaly, Fatma Salama Ahmed
International Immunopharmacology.2018; 59: 68. CrossRef
Association between diabetic peripheral neuropathy and heart rate variability in subjects with type 2 diabetes
S.K.M. Azizul Islam, Dongkyu Kim, Young-Sil Lee, Seong-Su Moon
Diabetes Research and Clinical Practice.2018; 140: 18. CrossRef
Diagnosis and Management of Diabetic Peripheral Neuropathy
Seong-Su Moon
The Journal of Korean Diabetes.2018; 19(3): 153. CrossRef
Clinical Importance of Diabetic Neuropathy
Tae Sun Park
The Journal of Korean Diabetes.2018; 19(3): 147. CrossRef
The U-shaped relationship between fibroblast growth factor 21 and microvascular complication in type 2 diabetes mellitus
Chan-Hee Jung, Sang-Hee Jung, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
Journal of Diabetes and its Complications.2017; 31(1): 134. CrossRef
Retinal Neurodegeneration Associated With Peripheral Nerve Conduction and Autonomic Nerve Function in Diabetic Patients
Kiyoung Kim, Seung-Young Yu, Hyung Woo Kwak, Eung Suk Kim
American Journal of Ophthalmology.2016; 170: 15. CrossRef
Letter: Cardiovascular Disease Predicts Severe Hypoglycemia in Patients with Type 2 Diabetes (Diabetes Metab J 2015;39:498-506)
Mi-Kyung Kim
Diabetes & Metabolism Journal.2016; 40(1): 83. CrossRef
Associations of serum anti-ganglioside antibodies and inflammatory markers in diabetic peripheral neuropathy
Shengjie Ge, Jing Xie, Lequn Zheng, Lijuan Yang, Hong Zhu, Xingbo Cheng, Feixia Shen
Diabetes Research and Clinical Practice.2016; 115: 68. CrossRef
Axonopathy in peripheral neuropathies: Mechanisms and therapeutic approaches for regeneration
Lila M. Landowski, P. James B. Dyck, JaNean Engelstad, Bruce V. Taylor
Journal of Chemical Neuroanatomy.2016; 76: 19. CrossRef
Adiponectin gene polymorphisms are associated with increased susceptibility to diabetic peripheral neuropathy
Yao Chen, Jian Wang, Lijing Wang, Peiji Huang, Zeng-Xian Tan, Huai-Jun Liu
Biomarkers.2015; 20(6-7): 474. CrossRef
Effect of Socio-Economic Status on the Prevalence of Diabetes
Yu Jeong Kim, Ja Young Jeon, Seung Jin Han, Hae Jin Kim, Kwan Woo Lee, Dae Jung Kim
Yonsei Medical Journal.2015; 56(3): 641. CrossRef
Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy
Heung Yong Jin, Hong Sun Baek, Tae Sun Park
Diabetes & Metabolism Journal.2015; 39(6): 461. CrossRef
Diabetic neuropathy and the sensory apparatus â€œmeissner corpuscle and merkel cellsâ€
Salma Alsunousi, Husnia I. Marrif
Frontiers in Neuroanatomy.2014;[Epub] CrossRef
Arterial Stiffness and Carotid Intima-Media Thickness in Diabetic Peripheral Neuropathy
Bulent Behlul Altunkeser
Medical Science Monitor.2014; 20: 2074. CrossRef

Original Articles

Prevalence and Management of Dyslipidemia in Korea: Korea National Health and Nutrition Examination Survey during 1998 to 2010: Eun Roh, Seung-Hyun Ko, Hyuk-Sang Kwon, Nan Hee Kim, Jae Hyeon Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Dae Jung Kim, Sung Hee Choi, Soo Lim, Bong-Yun Cha; Diabetes Metab J. 2013;37(6):433-449. Published online December 12, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.6.433

5,945 View
43 Download
74 Crossref

Abstract PDF PubReader

Background

Dyslipidemia is a major risk factor of cardiovascular disease. The aim of this study was to investigate the changing trends in the prevalence and management status of dyslipidemia among Korean adults.

Methods

The prevalence of dyslipidemia and the rates of awareness, treatment, and control of dyslipidemia were investigated in adults aged ≥20 years from the Korea National Health and Nutrition Surveys (KNHANES) 1998 to 2010. The updated National Cholesterol Education Program criteria was used, which define dyslipidemia as having one or more of the following lipid abnormalities: hypercholesterolemia (total cholesterol ≥240 mg/dL or diagnosis of dyslipidemia or use of lipid-lowering drugs), hypertriglyceridemia (≥150 mg/dL), hyper-low density lipoprotein (LDL) cholesterolemia (≥160 mg/dL or diagnosis of dyslipidemia or use of lipid-lowering drugs), and hypo-high density lipoprotein (HDL)-cholesterolemia (<40 mg/dL in men and <50 mg/dL in women).

Results

The number of participants was 6,921, 4,894, 5,312, 2,733, 6,295, 6,900, and 5,738 in KNHANES 1998, 2001, 2005, 2007, 2008, 2009, and 2010, respectively. Age-standardized prevalence rates of dyslipidemia were 54.0%, 65.8%, 66.5%, 60.6%, 58.7%, 58.9%, and 59.0% in 1998, 2001, 2005, 2007, 2008, 2009, and 2010, respectively. Hypertriglyceridemia and hypo-HDL-cholesterolemia were the two most frequent lipid abnormalities. The overall prevalence of hypercholesterolemia and hyper-LDL-cholesterolemia increased by 1.36- and 1.35-fold in 2010 compared with 2007, respectively. Awareness, treatment, and control rates of dyslipidemia improved over the period of surveys in both sexes. In 2010, about 30% of dyslipidemic patients who received lipid-lowering treatment reached target levels.

Conclusion

Although the management status of dyslipidemia has improved during recent years, effective strategy is required for achieving better prevention, treatment, and control of dyslipidemia.

Citations

Citations to this article as recorded by

SCORE and SCORE2 in East Asian Population
JungMin Choi, Soseul Sung, Sue K. Park, Seyong Park, Hyoyeong Kim, Myeong-Chan Cho, Bryan Williams, Hae-Young Lee
JACC: Asia.2024; 4(4): 265. CrossRef
Elevated Risk of Stroke in Young Adults After Traumatic Brain Injury: A Nationwide Study of 1 Million Individuals
Yoonjeong Choi, Jooeun Jeon, Eun Jin Ha, Chi Kyung Kim, Han Gil Seo, Byung‐Mo Oh, Ja‐Ho Leigh
Journal of the American Heart Association.2024;[Epub] CrossRef
Statin use and the risk of hepatocellular carcinoma among patients with chronic hepatitis B: an emulated target trial using longitudinal nationwide population cohort data
Dong Hyun Sinn, Danbee Kang, Yewan Park, Hyunsoo Kim, Yun Soo Hong, Juhee Cho, Geum-Youn Gwak
BMC Gastroenterology.2023;[Epub] CrossRef
Menopause management: A manual for primary care practitioners and nurse practitioners
Neelam Aggarwal, Meeta Meeta, Nirja Chawla
Journal of Mid-life Health.2022; 13(5): 2. CrossRef
New, Novel Lipid-Lowering Agents for Reducing Cardiovascular Risk: Beyond Statins
Kyuho Kim, Henry N. Ginsberg, Sung Hee Choi
Diabetes & Metabolism Journal.2022; 46(4): 517. CrossRef
Status of dyslipidemia management and statin undertreatment in Korean cancer survivors: A Korean National Health and Nutrition Examination Survey study
Sujeong Shin, Dong Wook Shin, In Young Cho, Su-Min Jeong, Hyein Jung
European Journal of Preventive Cardiology.2021; 28(8): 864. CrossRef
Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort
Byoungjin Park, Hye Sun Lee, Yong-Jae Lee
Translational Research.2021; 228: 42. CrossRef
Temporal change in the diagnosis and treatment rates of osteoporosis: results from the Korea National Health and Nutrition Examination Survey
Y. J. Choi, H.-B. Shin, B. Park, D. J. Kim, Y.-S. Chung
Osteoporosis International.2021; 32(9): 1777. CrossRef
Hypertriglyceridemia and Other Plasma Lipid Profile Abnormalities among People Living with Diabetes Mellitus in Ethiopia: A Systematic Review and Meta-Analysis
Baye Dagnew, Yigizie Yeshaw, Demeke Geremew, Dessie Abebaw Angaw, Henok Dagne, Mekuriaw Alemayehu, Meseret Derbew Molla, Yonas Akalu, Carlos R. Bueno Junior
BioMed Research International.2021; 2021: 1. CrossRef
Triglyceride to HDL-Cholesterol Ratio and the Incident Risk of Ischemic Heart Disease Among Koreans Without Diabetes: A Longitudinal Study Using National Health Insurance Data
Byoungjin Park, Dong Hyuk Jung, Hye Sun Lee, Yong Jae Lee
Frontiers in Cardiovascular Medicine.2021;[Epub] CrossRef
Three Musketeers for Lowering Cholesterol: Statins, Ezetimibe and Evolocumab
Qian Xu, Yiming Deng, Jun Xiao, Xiangrui Liu, Min Zhou, Zhong Ren, Juan Peng, Yaling Tang, Zhisheng Jiang, Zhihan Tang, Lushan Liu
Current Medicinal Chemistry.2021; 28(5): 1025. CrossRef
Achievement of LDL-C Targets Defined by ESC/EAS (2011) Guidelines in Risk-Stratified Korean Patients with Dyslipidemia Receiving Lipid-Modifying Treatments
Ye Seul Yang, Seo Young Lee, Jung-Sun Kim, Kyung Mook Choi, Kang Wook Lee, Sang-Chol Lee, Jung Rae Cho, Seung-Jin Oh, Ji-Hyun Kim, Sung Hee Choi
Endocrinology and Metabolism.2020; 35(2): 367. CrossRef
Statin Use and the Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B
Myung Ji Goh, Dong Hyun Sinn, Seonwoo Kim, Sook Young Woo, Hyun Cho, Wonseok Kang, Geum‐Youn Gwak, Yong‐Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
Hepatology.2020; 71(6): 2023. CrossRef
Low-density lipoprotein cholesterol goal attainment rates in high-risk patients with cardiovascular diseases and diabetes mellitus in Korea: a retrospective cohort study
Ye Seul Yang, Bo Ram Yang, Mi-Sook Kim, Yunji Hwang, Sung Hee Choi
Lipids in Health and Disease.2020;[Epub] CrossRef
Prevalencia de hipertrigliceridemia en adultos y factores cardiometabólicos asociados. Estudio SIMETAP-HTG
Antonio Ruiz-García, Ezequiel Arranz-Martínez, Beatriz López-Uriarte, Montserrat Rivera-Teijido, David Palacios-Martínez, Gema M. Dávila-Blázquez, Antonio Rosillo-González, José Antonio González-Posada Delgado, José Enrique Mariño-Suárez, Enrique Revilla-
Clínica e Investigación en Arteriosclerosis.2020; 32(6): 242. CrossRef
The Effect of High Carbohydrate-to-fat Intake Ratios on Hypo-HDL-cholesterolemia Risk and HDL-cholesterol Levels over a 12-year Follow-up
Hye Ah Lee, Hyoin An
Scientific Reports.2020;[Epub] CrossRef
Design and rationale of a randomized control trial testing the effectiveness of combined therapy with STAtin plus FENOfibrate and statin alone in non-diabetic, combined dyslipidemia patients with non-intervened intermediate coronary artery disease - STAFE
Taek-Geun Kwon, Albert Youngwoo Jang, Sang Wook Kim, Young Joon Hong, Jang-Ho Bae, Sung Yun Lee, Sang-Hyun Kim, Seung Hwan Han
Trials.2020;[Epub] CrossRef
Small-area variation of cardiovascular diseases and select risk factors and their association to household and area poverty in South Africa: Capturing emerging trends in South Africa to better target local level interventions
Ntabozuko Dwane, Njeri Wabiri, Samuel Manda, David Watkins
PLOS ONE.2020; 15(4): e0230564. CrossRef
Comprehensive Identification of Key Genes Involved in Development of Diabetes Mellitus-Related Atherogenesis Using Weighted Gene Correlation Network Analysis
Qi Huang, Guoxiong Deng, Rongguo Wei, Qiaoye Wang, Donghua Zou, Jinru Wei
Frontiers in Cardiovascular Medicine.2020;[Epub] CrossRef
The triglyceride-glucose index predicts ischemic heart disease risk in Koreans: a prospective study using National Health Insurance Service data
Byoungjin Park, Yong-Jae Lee, Hye Sun Lee, Dong-Hyuk Jung
Cardiovascular Diabetology.2020;[Epub] CrossRef
Prevalence of hypertriglyceridemia in adults and related cardiometabolic factors. SIMETAP-HTG study
Antonio Ruiz-García, Ezequiel Arranz-Martínez, Beatriz López-Uriarte, Montserrat Rivera-Teijido, David Palacios-Martínez, Gema M. Dávila-Blázquez, Antonio Rosillo-González, José Antonio González-Posada Delgado, José Enrique Mariño-Suárez, Enrique Revilla-
Clínica e Investigación en Arteriosclerosis (English Edition).2020; 32(6): 242. CrossRef
Incident cardiovascular disease and particulate matter air pollution in South Korea using a population-based and nationwide cohort of 0.2 million adults
Ok-Jin Kim, Soo Hyun Lee, Si-Hyuck Kang, Sun-Young Kim
Environmental Health.2020;[Epub] CrossRef
The association between low frequency of having breakfast and dyslipidemia in South Korean men and women
Doo Woong Lee, Dong-Woo Choi, Yeong Jun Ju, Sang Ah Lee, Eun-Cheol Park
European Journal of Clinical Nutrition.2019; 73(6): 896. CrossRef
Estimated glycemic load (eGL) of mixed meals and its associations with cardiometabolic risk factors among Korean adults: data from the 2013 ~ 2016 Korea National Health and Nutrition Examination Survey
Kyungho Ha, Kisun Nam, YoonJu Song
Journal of Nutrition and Health.2019; 52(4): 354. CrossRef
Working hours and nonalcoholic fatty liver disease according to sleep duration
Hwanjin Park, Soo-Jin Lee
Chronobiology International.2019; 36(12): 1671. CrossRef
An analysis of the associations between gender and metabolic syndrome components in Korean adults: a national cross-sectional study
Young-Mo Yang, Byung-Cheul Shin, Chihyoung Son, In-Hyuk Ha
BMC Endocrine Disorders.2019;[Epub] CrossRef
Time‐ and Dose‐Dependent Association of Statin Use With Risk of Clinically Relevant New‐Onset Diabetes Mellitus in Primary Prevention: A Nationwide Observational Cohort Study
Min Jung Ko, Ae Jeong Jo, Yun Jung Kim, Shin Hee Kang, Songhee Cho, Sang‐Ho Jo, Cheol‐Young Park, Sung‐Cheol Yun, Woo Je Lee, Duk‐Woo Park
Journal of the American Heart Association.2019;[Epub] CrossRef
Dyslipidemia associated with body constitution in Traditional Chinese Medicine
Qiuping Li, Qing Kong, Zihui Tang
Traditional Medicine and Modern Medicine.2019; 02(02): 59. CrossRef
Effect of Sulgidduk containing pine needle juice on lipid metabolism in high fat-cholesterol diet induced dyslipidemic rats
Yunjung Lee, Jae-Hee Park, Eunju Park
Journal of Nutrition and Health.2019; 52(1): 6. CrossRef
Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study
Jun Namkung, Joon Hyung Sohn, Jae Seung Chang, Sang-Wook Park, Jang-Young Kim, Sang-Baek Koh, In Deok Kong, Kyu-Sang Park
Diabetes & Metabolism Journal.2019; 43(4): 521. CrossRef
Total cholesterol variability and risk of atrial fibrillation: A nationwide population-based cohort study
Eun Roh, Hye Soo Chung, Ji Sung Lee, Jung A. Kim, You-Bin Lee, So-hyeon Hong, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi, Stefan Kiechl
PLOS ONE.2019; 14(4): e0215687. CrossRef
Low Levels of Low-Density Lipoprotein Cholesterol and Mortality Outcomes in Non-Statin Users
Ki-Chul Sung, Ji Hye Huh, Seungho Ryu, Jong-Young Lee, Eleonora Scorletti, Christopher D Byrne, Jang Young Kim, Dae Sung Hyun, Sang-Baek Ko
Journal of Clinical Medicine.2019; 8(10): 1571. CrossRef
The differential effects of changes in individual macronutrient intake on changes in lipid concentrations during childhood: From the Ewha Birth & Growth Cohort
Hye Ah Lee, Hyo Jeong Hwang, Se Young Oh, Eun Ae Park, Su Jin Cho, Hae Soon Kim, Hyesook Park
Clinical Nutrition.2018; 37(3): 1027. CrossRef
Association between cotinine‐verified smoking status and risk of nonalcoholic fatty liver disease
Nam Hee Kim, Yoon Suk Jung, Hyun Pyo Hong, Jung Ho Park, Hong Joo Kim, Dong Il Park, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim
Liver International.2018; 38(8): 1487. CrossRef
The prevalence, awareness, and treatment of lipid abnormalities in Iranian adults: Surveillance of risk factors of noncommunicable diseases in Iran 2016
Zahra Aryan, Negar Mahmoudi, Ali Sheidaei, Shahabeddin Rezaei, Zohreh Mahmoudi, Kimyia Gohari, Nazila Rezaei, Mohammad Javad Hajipour, Arezou Dilmaghani-Marand, Farideh Razi, Mahdi Sabooni, Farzad Kompani, Alireza Delavari, Bagher Larijani, Farshad Farzad
Journal of Clinical Lipidology.2018; 12(6): 1471. CrossRef
Low-carbohydrate diet and the risk of metabolic syndrome in Korean adults
K. Ha, H. Joung, Y. Song
Nutrition, Metabolism and Cardiovascular Diseases.2018; 28(11): 1122. CrossRef
Association of change in total cholesterol level with mortality: A population-based study
Su-Min Jeong, Seulggie Choi, Kyuwoong Kim, Sung-Min Kim, Gyeongsil Lee, Joung Sik Son, Jae-Moon Yun, Sang Min Park, Katriina Aalto-Setala
PLOS ONE.2018; 13(4): e0196030. CrossRef
Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
Diabetes & Metabolism Journal.2018; 42(5): 415. CrossRef
Evaluating the prevalence, awareness, and control of hypertension, diabetes, and dyslipidemia in Korea using the NHIS-NSC database
Sunjoo Boo, Young Joo Yoon, Hyunjin Oh
Medicine.2018; 97(51): e13713. CrossRef
New and Future Parenteral Therapies for the Management of Lipid Disorders
Roberto Garcia, Jaime Burkle
Archives of Medical Research.2018; 49(8): 538. CrossRef
Association between Dietary Pattern and Incidence of Cholesterolemia in Korean Adults: The Korean Genome and Epidemiology Study
Jieul Lee, Jihye Kim
Nutrients.2018; 10(1): 53. CrossRef
Efficacy and Safety of Adding Omega-3 Fatty Acids in Statin-treated Patients with Residual Hypertriglyceridemia: ROMANTIC (Rosuvastatin-OMAcor iN residual hyperTrIglyCeridemia), a Randomized, Double-blind, and Placebo-controlled Trial
Chee Hae Kim, Kyung Ah Han, Jaemyung Yu, Sang Hak Lee, Hui Kyung Jeon, Sang Hyun Kim, Seok Yeon Kim, Ki Hoon Han, Kyungheon Won, Dong-Bin Kim, Kwang-Jae Lee, Kyungwan Min, Dong Won Byun, Sang-Wook Lim, Chul Woo Ahn, SeongHwan Kim, Young Joon Hong, Jidong
Clinical Therapeutics.2018; 40(1): 83. CrossRef
Effects of Abdominal Obesity and Risk Drinking on the Hypertension Risk in Korean Adults
Eun Sook Lee
Journal of Korean Academy of Community Health Nursing.2018; 29(3): 349. CrossRef
Does Adjuvant Treatment With Ginkgo Biloba to Statins Have Additional Benefits in Patients With Dyslipidemia?
Yu Fan, Xin Jin, Changfeng Man, Dandan Gong
Frontiers in Pharmacology.2018;[Epub] CrossRef
Relationship with Smoking and Dyslipidemia in Korean Adults
Dong Youl Shin, Young Keun Jang, Jae Hoon Lee, Jeong Hoon Wee, Dong Ho Chun
Journal of the Korean Society for Research on Nicotine and Tobacco.2017; 8(2): 73. CrossRef
Prevalence and Clinical Characteristics of Dyslipidemia in Koreans
Jee-Sun Jeong, Hyuk-Sang Kwon
Endocrinology and Metabolism.2017; 32(1): 30. CrossRef
Management Status of Cardiovascular Disease Risk Factors for Dyslipidemia among Korean Adults
Jongseok Lee, Heejeong Son, Ohk-Hyun Ryu
Yonsei Medical Journal.2017; 58(2): 326. CrossRef
Application of the 2013 American College of Cardiology/American Heart Association Cholesterol Guideline to the Korean National Health and Nutrition Examination Surveys from 1998 to 2012
Young Shin Song, Tae Jung Oh, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang, Kyong Soo Park, Soo Lim
Diabetes & Metabolism Journal.2017; 41(1): 38. CrossRef
Dietary carbohydrate and fat intakes are differentially associated with lipid abnormalities in Korean adults
SuJin Song, Won O. Song, YoonJu Song
Journal of Clinical Lipidology.2017; 11(2): 338. CrossRef
Metabolic Syndrome Causes Cardiovascular Disease under Stable Statin Medication
Sang-Cheol Cho, Hoonhee Lee, Hyo-Jung Nam, Ki Hoon Han
Journal of Lipid and Atherosclerosis.2017; 6(2): 75. CrossRef
Improved trends in cardiovascular complications among subjects with type 2 diabetes in Korea: a nationwide study (2006–2013)
Chang Hee Jung, Jin Ook Chung, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko, Joong-Yeol Park
Cardiovascular Diabetology.2017;[Epub] CrossRef
Association Between the Awareness of Dyslipidemia and Health Behavior for Control of Lipid Levels Among Korean Adults with Dyslipidemia
In Young Cho, Hwa Yeon Park, Kiheon Lee, Woo Kyung Bae, Se Young Jung, Hye Jin Ju, Jae Kyeong Song, Jong Soo Han
Korean Journal of Family Medicine.2017; 38(2): 64. CrossRef
Effect of statin on hepatocellular carcinoma in patients with type 2 diabetes: A nationwide nested case‐control study
Gyuri Kim, Suk‐Yong Jang, Eugene Han, Yong‐ho Lee, Se‐young Park, Chung Mo Nam, Eun Seok Kang
International Journal of Cancer.2017; 140(4): 798. CrossRef
Association of dietary intakes of total and subtypes of fat substituted for carbohydrate with metabolic syndrome in Koreans
Kyong Won Lee, Yoonsu Cho, Garam Jo, Yoo Kyoung Park, Min-Jeong Shin
Endocrine Journal.2016; 63(11): 991. CrossRef
Pre-treatment with simvastatin prevents the induction of diet-induced atherosclerosis in a rabbit model
Nikolaos Oikonomidis, Nikolaos Kavantzas, Laskarina-Maria Korou, Panagiotis Konstantopoulos, Vasilios Pergialiotis, Evangelos Misiakos, Ioannis Rizos, Christos Verikokos, Despina N. Perrea
Biomedical Reports.2016; 5(6): 667. CrossRef
Comparative analysis of the efficacy of omega-3 fatty acids for hypertriglyceridaemia management in Korea
H.-S. Kim, H. Kim, Y. J. Jeong, S. J. Yang, S. J. Baik, H. Lee, S.-H. Lee, J. H. Cho, I.-Y. Choi, H. W. Yim, K.-H. Yoon
Journal of Clinical Pharmacy and Therapeutics.2016; 41(5): 508. CrossRef
Parks and Green Areas Are Associated with Decreased Risk for Hyperlipidemia
Hye-Jin Kim, Jin-Young Min, Hyun-Jin Kim, Kyoung-Bok Min
International Journal of Environmental Research and Public Health.2016; 13(12): 1205. CrossRef
Analysis and comparison of statin prescription patterns and outcomes according to clinical department
H.-S. Kim, H. Kim, H. Lee, B. Park, S. Park, S.-H. Lee, J. H. Cho, H. Song, J. H. Kim, K.-H. Yoon, I. Y. Choi
Journal of Clinical Pharmacy and Therapeutics.2016; 41(1): 70. CrossRef
Dyslipidemia patterns are differentially associated with dietary factors
SuJin Song, Hee Young Paik, Minseon Park, YoonJu Song
Clinical Nutrition.2016; 35(4): 885. CrossRef
Epidemiology of dyslipidemia in Korea
Hyeon Chang Kim
Journal of the Korean Medical Association.2016; 59(5): 352. CrossRef
Difference between old and young adults in contribution of β‐cell function and sarcopenia in developing diabetes mellitus
Bo Kyung Koo, Eun Roh, Ye Seul Yang, Min Kyong Moon
Journal of Diabetes Investigation.2016; 7(2): 233. CrossRef
Economic Evaluation of Rosuvastatin and Atorvastatin for the Treatment of Dyslipidemia from a Korean Health System Perspective
Sunghwan Suh, Chang Hee Jung, Soon-Jun Hong, Jung-Sun Kim, Byung Ju Song, Hyun Soon Sohn, Sung Hee Choi
Journal of Lipid and Atherosclerosis.2016; 5(1): 61. CrossRef
Obesity and Hyperglycemia in Korean Men with Klinefelter Syndrome: The Korean Endocrine Society Registry
Seung Jin Han, Kyung-Soo Kim, Wonjin Kim, Jung Hee Kim, Yong-ho Lee, Ji Sun Nam, Ji A Seo, Bu Kyung Kim, Jihyun Lee, Jin Ook Chung, Min-Hee Kim, Tae-Seo Sohn, Han Seok Choi, Seong Bin Hong, Yoon-Sok Chung
Endocrinology and Metabolism.2016; 31(4): 598. CrossRef
Effects of mulberry leaf extract on blood glucose and serum lipid profiles in patients with type 2 diabetes mellitus: A systematic review
Seung-Ok Shin, Hyun-Ju Seo, Hyunyoung Park, Hyun Jin Song
European Journal of Integrative Medicine.2016; 8(5): 602. CrossRef
Diabetic Cardiovascular Autonomic Neuropathy Predicts Recurrent Cardiovascular Diseases in Patients with Type 2 Diabetes
Seon-Ah Cha, Jae-Seung Yun, Tae-Seok Lim, Kyoungil Min, Ki-Ho Song, Ki-Dong Yoo, Yong-Moon Park, Yu-Bae Ahn, Seung-Hyun Ko, James M Wright
PLOS ONE.2016; 11(10): e0164807. CrossRef
Effects of Age, Sex, and Menopausal Status on Blood Cholesterol Profile in the Korean Population
Ji Hye Park, Myung Ha Lee, Jee-Seon Shim, Dong Phil Choi, Bo Mi Song, Seung Won Lee, Hansol Choi, Hyeon Chang Kim
Korean Circulation Journal.2015; 45(2): 141. CrossRef
Is nutritional labeling associated with individual health? The effects of labeling-based awareness on dyslipidemia risk in a South Korean population
Jong Yeob Kim, Ki Hong Kweon, Min Jae Kim, Eun-Cheol Park, Suk-Yong Jang, Woorim Kim, Kyu-Tae Han
Nutrition Journal.2015;[Epub] CrossRef
Cost-effectiveness analysis of low density lipoprotein cholesterol-lowering therapy in hypertensive patients with type 2 diabetes in Korea: single-pill regimen (amlodipine/atorvastatin) versus double-pill regimen (amlodipine+atorvastatin)
Ji-Hyun Park, Yong-Ho Lee, Su-Kyoung Ko, Bong-Soo Cha
Epidemiology and Health.2015; 37: e2015010. CrossRef
Application of New Cholesterol Guidelines to the Korean Adult Diabetic Patients
Bu Kyung Kim, Hyeon Chang Kim, Kyoung Hwa Ha, Dae Jung Kim
Journal of Korean Medical Science.2015; 30(11): 1612. CrossRef
Undiagnosed diabetes is prevalent in younger adults and associated with a higher risk cardiometabolic profile compared to diagnosed diabetes
Yong-ho Lee, Ehrin J. Armstrong, Gyuri Kim, Jaewon Oh, Seok-Min Kang, Byung-Wan Lee, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Lee, Christos S. Mantzoros, Eun Seok Kang
American Heart Journal.2015; 170(4): 760. CrossRef
New Drugs for Treating Dyslipidemia: Beyond Statins
Chang Ho Ahn, Sung Hee Choi
Diabetes & Metabolism Journal.2015; 39(2): 87. CrossRef
Can increased visceral adiposity without body weight changes accelerate carotid atherosclerosis in South Korean participants with type 2 diabetes?
Chul Sik Kim, Soo-Kyung Kim, Maria Rosario G. Araneta, Eun Jig Lee, Elizabeth Barrett-Connor, Kab Bum Huh
Journal of Diabetes and its Complications.2015; 29(8): 1085. CrossRef
Prevalence and Management of Dyslipidemia Among Korean Adults: KNHANES 2010-2012
Sungok Jang, Jongseok Lee
Journal of the Korea Academia-Industrial cooperation Society.2015; 16(11): 7978. CrossRef
Prevalence and Gender-Related Characteristics of Metabolic Syndrome in Korean Community
Kyung-Taek Park, Hack-Lyoung Kim, Sang-Hyun Kim, Myung-A Kim, Euijae Lee, Jonghanne Park, Sang-Ho Jo, Sung Rae Kim, Jaetaek Kim, Chee Jeong Kim, Moon-Kyu Lee, Hyun Ho Shin
Journal of Lipid and Atherosclerosis.2014; 3(2): 89. CrossRef

Prevalence of Diabetes and Prediabetes according to Fasting Plasma Glucose and HbA1c: Ja Young Jeon, Seung-Hyun Ko, Hyuk-Sang Kwon, Nan Hee Kim, Jae Hyeon Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Soo Lim, Sung Hee Choi, Myoung-jin Jang, Yuna Kim, Kyungwon Oh, Dae Jung Kim, Bong-Yun Cha; Diabetes Metab J. 2013;37(5):349-357. Published online October 17, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.5.349

7,723 View
76 Download
117 Crossref

Abstract PDF PubReader

Background

Due to the inconvenience of performing oral glucose tolerance tests and day to day variability in glucose level, glycated hemoglobin (HbA1c) has been recommended by the American Diabetes Association as a method to diagnose diabetes. In addition, the Korean Diabetes Association has also recommended the use of HbA1c as a diagnostic test for diabetes. In this study, we evaluated the prevalence of diabetes according to fasting plasma glucose (FPG) level only or the combination of FPG and HbA1c tests.

Methods

Data from the 2011 Korea National Health and Nutrition Examination Survey (KNHANES) were analyzed. Among 5,811 subjects aged 30 years or older, 5,020 were selected after excluding the data of fasting time <8 hours, missing values from fasting glucose or HbA1c level, previous diagnosis of diabetes made by physicians, or current use of antidiabetic medications. Diabetes was defined as FPG ≥126 mg/dL, previous diagnosis of diabetes made by a medical doctor, current use of antidiabetic medications, and/or HbA1c ≥6.5%. Prediabetes was defined as FPG of 100 to 125 mg/dL and/or HbA1c of 5.7% to 6.4%.

Results

When we used FPG only, the prevalence of diabetes and prediabetes were 10.5% (men, 12.6%; women, 8.5%) and 19.3% (men, 23.8%; women, 14.9%), respectively. When HbA1c was included as a diagnostic test, the prevalence of diabetes and prediabetes increased to 12.4% (men, 14.5%; women, 10.4%) and 38.3% (men, 41%; women, 35.7%), respectively. Participants with HbA1c ≥6.5% and fasting glucose level <126 mg/dL were older and had lower estimated glomerular filtration rate.

Conclusion

We concluded that using fasting glucose level only may result in an underestimation of diabetes and prediabetes. HbA1c is an acceptable complementary diagnostic test for diabetes in Korean patients. However, national standardization is needed to order to use HbA1c as a diagnostic method of diabetes and prediabetes.

Citations

Citations to this article as recorded by

Validation of the Framingham Diabetes Risk Model Using Community-Based KoGES Data
Hye Ah Lee, Hyesook Park, Young Sun Hong
Journal of Korean Medical Science.2024;[Epub] CrossRef
Dietary patterns and the risk of diabetes in Korean adults: A cross-sectional and prospective cohort study
Jiyoung Hwang, Hyesook Kim, Oran Kwon
Nutrition.2024; 125: 112491. CrossRef
Diabetes and prediabetes prevalence through a community-based screening initiative in Alqunfudah, Saudi Arabia
Saleh Ahmed Alshaikhi, Ahmed Madini Alamri, Ibrahim Yahya Alzilai, Ageel Ahmad Alghanimi, Ali Mohammad Alrufaidi, Ahmed Mohammed Alrufaidi, Ahmed Elsayed Bader, Ahmed Abushaisha Abdelmoniem, Ayoub Ali Alshaikh, Omar Ahmed Alshaikhi, Mohammed Ahmed Alshaik
Future Science OA.2024;[Epub] CrossRef
Investigating the Effects of Diet-Induced Prediabetes on Skeletal Muscle Strength in Male Sprague Dawley Rats
Mandlakazi Dlamini, Andile Khathi
International Journal of Molecular Sciences.2024; 25(7): 4076. CrossRef
Investigating Factors Influencing the National Cancer Screening Program among Older Individuals in Republic of Korea—Data from the Korea National Health and Nutrition Examination Survey VIII
Seok Hwan Kim, Hyo Eun Park
Healthcare.2024; 12(12): 1237. CrossRef
Oxidative balance scores in Korean adults are associated with periodontitis
Jeong‐Hwa Seon, Na‐Yeong Kim, Ji‐Eun Kim, Choong‐Ho Choi, Ki‐Ho Chung
Journal of Periodontology.2024;[Epub] CrossRef
Association between gingivitis, tooth loss and cardiovascular risk: Insights from a 10-year nationwide cohort study of 3.7 million Koreans
Seung Yeon Lee, César Félix Cayo-Rojas
PLOS ONE.2024; 19(8): e0308250. CrossRef
Relationship between Marriage and Prediabetes among Healthcare Workers: Mediating Effect of Triglycerides
Yong-Hsin Chen, Jia-June Lin, Hsiu-Mei Tang, Ching-Wen Yang, Gwo-Ping Jong, Yi-Sun Yang
Medicina.2024; 60(9): 1418. CrossRef
Diabetes screening in South Korea: a new estimate of the number needed to screen to detect diabetes
Kyoung Hwa Ha, Kyung Ae Lee, Kyung-Do Han, Min Kyong Moon, Dae Jung Kim
The Korean Journal of Internal Medicine.2023; 38(1): 93. CrossRef
Comparison of diagnostic accuracy for diabetes diagnosis: A systematic review and network meta-analysis
Khanh N. C. Duong, Chia Jie Tan, Sasivimol Rattanasiri, Ammarin Thakkinstian, Thunyarat Anothaisintawee, Nathorn Chaiyakunapruk
Frontiers in Medicine.2023;[Epub] CrossRef
Evaluation of the Association between Amount and Type of Milk Consumption and Periodontitis: Data from the Korea National Health and Nutrition Examination Survey (2016–2018)
Eun Jeong Min, Siseong Jeong, Jun-Beom Park
Nutrients.2023; 15(4): 914. CrossRef
Association between body mass index and reversion to normoglycemia from impaired fasting glucose among Chinese adults: a 5-year cohort study
Yong Han, Haofei Hu, Zhiqiang Huang, Dehong Liu
Frontiers in Endocrinology.2023;[Epub] CrossRef
Evaluation of calcium/magnesium ratio in patients with type 2 diabetes mellitus
Kamile Yücel, Ali Fuat Gürbüz
Turkish Journal of Biochemistry.2023; 48(3): 327. CrossRef
Association of dietary sodium intake with impaired fasting glucose in adult cancer survivors: A population-based cross-sectional study
Kyuwoong Kim, Hamee Kim, Tae Joon Jun, Young-Hak Kim, Dong Keon Yon
PLOS ONE.2023; 18(5): e0286346. CrossRef
Sitagliptin: the fixed combination of the first dipeptidyl peptidase 4 inhibitor and metformin
L. V. Egshatyan
Meditsinskiy sovet = Medical Council.2023; (13): 116. CrossRef
Reply
Kiyoshi Tamura
Annals of Vascular Diseases.2023; 16(3): 244. CrossRef
The inverse association between DNA gaps and HbA1c levels in type 2 diabetes mellitus
Jirapan Thongsroy, Apiwat Mutirangura
Scientific Reports.2023;[Epub] CrossRef
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c
Bin Zhou, Kate E. Sheffer, James E. Bennett, Edward W. Gregg, Goodarz Danaei, Rosie K. Singleton, Jonathan E. Shaw, Anu Mishra, Victor P. F. Lhoste, Rodrigo M. Carrillo-Larco, Andre P. Kengne, Nowell H. Phelps, Rachel A. Heap, Archie W. Rayner, Gretchen A
Nature Medicine.2023; 29(11): 2885. CrossRef
Lobeglitazone and Its Therapeutic Benefits: A Review
Balamurugan M, Sarumathy S, Robinson R
Cureus.2023;[Epub] CrossRef
Position Statement on the Appropriateness and Significance of Adding the Glycated Hemoglobin Test to the National Health Examination
Ji Hye Kim, Dae Jung Kim, Jaehyun Kim, Sangjoon Park, Kyunghoon Lee, Jun Goo Kang, Eu Jeong Ku, Su Kyoung Kwon, Won Jun Kim, Young Sang Lyu, Jang Won Son, Young Sil Eom, Kyung Ae Lee, Jeongrim Lee, Jung Min Lee, Jung Hwa Lee, Jung Hwa Jung, Hochan Cho, Da
The Journal of Korean Diabetes.2023; 24(4): 178. CrossRef
Trends in Prediabetes and Non-Alcoholic Fatty Liver Disease Associated with Abdominal Obesity among Korean Children and Adolescents: Based on the Korea National Health and Nutrition Examination Survey between 2009 and 2018
Kyungchul Song, Goeun Park, Hye Sun Lee, Myeongseob Lee, Hae In Lee, Jungmin Ahn, Eunbyoul Lee, Han Saem Choi, Junghwan Suh, Ahreum Kwon, Ho-Seong Kim, Hyun Wook Chae
Biomedicines.2022; 10(3): 584. CrossRef
Metabolic Effects of an Oral Glucose Tolerance Test Compared to the Mixed Meal Tolerance Tests: A Narrative Review
Marlene Lages, Renata Barros, Pedro Moreira, Maria P. Guarino
Nutrients.2022; 14(10): 2032. CrossRef
Diabetes Prevalence and Associated Risk Factors among Women in a Rural District of Nepal Using HbA1c as a Diagnostic Tool: A Population-Based Study
Chandra Yogal, Sunila Shakya, Biraj Karmarcharya, Rajendra Koju, Astrid Kamilla Stunes, Mats Peder Mosti, Miriam K. Gustafsson, Bjørn Olav Åsvold, Berit Schei, Unni Syversen
International Journal of Environmental Research and Public Health.2022; 19(12): 7011. CrossRef
Prediabetes diagnosis is associated with the progression of coronary artery calcification: The Kangbuk Samsung Health Study
In Young Choi, Yoosoo Chang, Yoosun Cho, Jeonggyu Kang, Hyun‐Suk Jung, Sarah H. Wild, Christopher D. Byrne, Seungho Ryu
Diabetes, Obesity and Metabolism.2022; 24(11): 2118. CrossRef
Investigating the Effects of Diet-Induced Pre-Diabetes on the Functioning of Calcium-Regulating Organs in Male Sprague Dawley Rats: Effects on Selected Markers
Karishma Naidoo, Phikelelani S. Ngubane, Andile Khathi
Frontiers in Endocrinology.2022;[Epub] CrossRef
Oncometabolic surgery in gastric cancer patients with type 2 diabetes
Yun Suk Choi, Jin Wook Yi, Woo Young Shin, Yoonseok Heo
Scientific Reports.2022;[Epub] CrossRef
Epidemiology of prediabetes mellitus among hill tribe adults in Thailand
Tawatchai Apidechkul, Chalitar Chomchiei, Panupong Upala, Ratipark Tamornpark, Xi Pan
PLOS ONE.2022; 17(7): e0271900. CrossRef
Ameliorative Effects of Annona muricata Leaf Ethanol Extract on Renal Morphology of Alloxan-Induced Mice
Supri Irianti Handayani, Mutiara Intan Permata Sari, Meilania Saraswati Sardjana, Kusmardi Kusmardi, Siti Nurbaya, Rosmalena Rosmalena, Ernawati Sinaga, Vivitri Dewi Prasasty
Applied Sciences.2022; 12(18): 9141. CrossRef
ADAM17 cleaves the insulin receptor ectodomain on endothelial cells and causes vascular insulin resistance
Thaysa Ghiarone, Jorge A. Castorena-Gonzalez, Christopher A. Foote, Francisco I. Ramirez-Perez, Larissa Ferreira-Santos, Francisco J. Cabral-Amador, Roger de la Torre, Rama R. Ganga, Andrew A. Wheeler, Camila Manrique-Acevedo, Jaume Padilla, Luis A. Marti
American Journal of Physiology-Heart and Circulatory Physiology.2022; 323(4): H688. CrossRef
A causal relationship between alcohol intake and type 2 diabetes mellitus: A two-sample Mendelian randomization study
Meiling Liu, Sunmin Park
Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(12): 2865. CrossRef
Diabetes stabilisation during COVID-19: A case history
Linda Nazarko
Independent Nurse.2021; 2021(1): 16. CrossRef
Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status
Chan-Hee Jung, Jang Won Son, Shinae Kang, Won Jun Kim, Hun-Sung Kim, Hae Soon Kim, Mihae Seo, Hye-Jung Shin, Seong-Su Lee, Su Jin Jeong, Yongin Cho, Seung Jin Han, Hyang Mi Jang, Mira Rho, Shinbi Lee, Mihyun Koo, Been Yoo, Jung-Wha Moon, Hye Young Lee, Ja
Diabetes & Metabolism Journal.2021; 45(1): 1. CrossRef
Does autonomic nervous system dysfunction influence cardiovascular disease risk in young adults with intellectual disability?
Clara C. Zwack, Rachael McDonald, Ainura Tursunalieva, Amali Cooray, Gavin W. Lambert, Elisabeth A. Lambert
American Journal of Physiology-Heart and Circulatory Physiology.2021; 320(2): H891. CrossRef
Prevalence of Prediabetes and Undiagnosed Diabetes Among Kuwaiti Adults: A Cross-Sectional Study
Anwar Mohammad, Ali H Ziyab, Talal Mohammad
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 2167. CrossRef
The prevalence of diabetes amongst young Emirati female adults in the United Arab Emirates: A cross-sectional study
Maysm N. Mohamad, Leila Cheikh Ismail, Lily Stojanovska, Vasso Apostolopoulos, Jack Feehan, Amjad H. Jarrar, Ayesha S. Al Dhaheri, Muhammad Sajid Hamid Akash
PLOS ONE.2021; 16(6): e0252884. CrossRef
The prevalence and correlates of pre-diabetes in middle- to older-aged Irish adults using three diagnostic methods
Kate Junker, Claire M. Buckley, Seán R. Millar, Sinéad Flynn, Janas M. Harrington, Patricia M. Kearney, Ivan J. Perry, Muhammad Sajid Hamid Akash
PLOS ONE.2021; 16(6): e0253537. CrossRef
Korea National Health and Nutrition Examination Survey, 20th anniversary: accomplishments and future directions
Kyungwon Oh, Yoonjung Kim, Sanghui Kweon, Soyeon Kim, Sungha Yun, Suyeon Park, Yeon-Kyeng Lee, Youngtaek Kim, Ok Park, Eun Kyeong Jeong
Epidemiology and Health.2021; 43: e2021025. CrossRef
The Use of Mobile Personal Health Records for Hemoglobin A1c Regulation in Patients With Diabetes: Retrospective Observational Study
Dongjin Seo, Yu Rang Park, Yura Lee, Ji Young Kim, Joong-Yeol Park, Jae-Ho Lee
Journal of Medical Internet Research.2020; 22(6): e15372. CrossRef
Optimal fasting plasma glucose and haemoglobin A1c levels for screening of prediabetes and diabetes according to 2‐hour plasma glucose in a high‐risk population: The Korean Diabetes Prevention Study
Seon‐Ah Cha, Suk Chon, Jae‐Seung Yun, Sang Youl Rhee, Sun‐Young Lim, Kun‐Ho Yoon, Yu‐Bae Ahn, Seung‐Hyun Ko, Jeong‐Taek Woo, Jin‐Hee Lee
Diabetes/Metabolism Research and Reviews.2020;[Epub] CrossRef
The additive effect of type 2 diabetes on fibrinogen, von Willebrand factor, tryptophan and threonine in people living with HIV
Michelle L. Harrison, Anthony S. Wolfe, Jonathan Fordyce, Jamie Rock, Alexandra A. García, Julie A. Zuñiga
Amino Acids.2019; 51(5): 783. CrossRef
Prevalence of Diabetes Mellitus in Adult Residents of Rural Regions of Grash Town, Fars, Iran during 2015-201
H. Soori, M.N. Mohammadi, J. Yoosefi Lebni
Health Education and Health Promotion.2019; 7(2): 89. CrossRef
Understanding prediabetes: definition, prevalence, burden and treatment options for an emerging disease
Kristian Rett, Ulrike Gottwald-Hostalek
Current Medical Research and Opinion.2019; 35(9): 1529. CrossRef
Does reviewing fasting plasma glucose results patterns before glycosylated hemoglobin testing in type-2 diabetic patients lead to better testing decision?
Wichaporn Intharachuti, Jiruth Sriratanaban
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(3): 2080. CrossRef
Discrepancies between Glycosylated Hemoglobin and Fasting Plasma Glucose for Diagnosing Impaired Fasting Glucose and Diabetes Mellitus in Korean Youth and Young Adults
Jieun Lee, Young Ah Lee, Jae Hyun Kim, Seong Yong Lee, Choong Ho Shin, Sei Won Yang
Diabetes & Metabolism Journal.2019; 43(2): 174. CrossRef
Colorectal Cancer Risks According to Sex Differences in Patients With Type II Diabetes Mellitus: A Korean Nationwide Population-Based Cohort Study
Ji Min Lee, Kang-Moon Lee, Dae Bum Kim, Seung-Hyun Ko, Yong Gyu Park
Clinical and Translational Gastroenterology.2019; 10(10): e00090. CrossRef
Isolated HbA1c identifies a different subgroup of individuals with type 2 diabetes compared to fasting or post-challenge glucose in Asian Indians: The CARRS and MASALA studies
U.P. Gujral, D. Prabhakaran, R. Pradeepa, N.R. Kandula, D. Kondal, M. Deepa, N.A. Zakai, R.M. Anjana, G. Rautela, V. Mohan, K.M.V. Narayan, N. Tandon, A.M. Kanaya
Diabetes Research and Clinical Practice.2019; 153: 93. CrossRef
Diabetes Fact Sheets in Korea, 2018: An Appraisal of Current Status
Bo-Yeon Kim, Jong Chul Won, Jae Hyuk Lee, Hun-Sung Kim, Jung Hwan Park, Kyoung Hwa Ha, Kyu Chang Won, Dae Jung Kim, Kyong Soo Park
Diabetes & Metabolism Journal.2019; 43(4): 487. CrossRef
Lack of association between particulate air pollution and blood glucose levels and diabetic status in peri-urban India
Ariadna Curto, Otavio Ranzani, Carles Milà, Margaux Sanchez, Julian D. Marshall, Bharati Kulkarni, Santhi Bhogadi, Sanjay Kinra, Gregory A. Wellenius, Cathryn Tonne
Environment International.2019; 131: 105033. CrossRef
Diabetes Prevalence Survey of Pakistan (DPS-PAK): prevalence of type 2 diabetes mellitus and prediabetes using HbA1c: a population-based survey from Pakistan
Azizul Hasan Aamir, Zia Ul-Haq, Saeed A Mahar, Faisal Masood Qureshi, Ibrar Ahmad, Ali Jawa, Aisha Sheikh, Abbas Raza, Sheraz Fazid, Zahid Jadoon, Osama Ishtiaq, Nauman Safdar, Hussain Afridi, Adrian H Heald
BMJ Open.2019; 9(2): e025300. CrossRef
Evaluation of the associations between immunoglobulin E levels and the number of natural teeth
Kyungdo Han, Eunjoo Lee, Jun-Beom Park
Journal of the Formosan Medical Association.2018; 117(7): 605. CrossRef
Clinical implications of age and sex in the prevalence of periodontitis in Korean adults with diabetes
Kyungdo Han, Jun‑Beom Park
Experimental and Therapeutic Medicine.2018;[Epub] CrossRef
Clinical implication of fasting glucose and systolic/diastolic blood pressure on the prevalence of periodontitis in non‑diabetic and non‑hypertensive adults using nationally representative data
Kyungdo Han, Jun‑Beom Park
Experimental and Therapeutic Medicine.2018;[Epub] CrossRef
Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis
Seung-Hyun Ko, Kyungdo Han, Yong-ho Lee, Junghyun Noh, Cheol-Young Park, Dae-Jung Kim, Chang Hee Jung, Ki-Up Lee, Kyung-Soo Ko
Diabetes & Metabolism Journal.2018; 42(2): 93. CrossRef
Glycated heamoglobin A1c as a tool for epidemiological studies to assess diabetes prevalence: How has it been used since its official recommendation for diabetes diagnosis?
D. Simon
Diabetes & Metabolism.2018; 44(3): 197. CrossRef
Type 2 Diabetes Mellitus and Cognitive Function in the Elderly
Nazila Malekian, Seyed Reza Hosseini, Sussan Moudi, Mohammad Ali Bayani, Farzan Kheirkhah, Ali Bijani, Aylar Khalilipour
Iranian Journal of Psychiatry and Behavioral Sciences.2018;[Epub] CrossRef
Evaluation of an association between long sleep duration and periodontal disease among men and women using nationally representative data
Kyungdo Han, Yong-Moon Park, Jun-Beom Park
Gaceta Sanitaria.2018; 32(2): 143. CrossRef
Significance of prediabetes as a nosological entity
Ladislav Stepanek, Dagmar Horakova, Marie Nakladalova, Lubica Cibickova, David Karasek, Josef Zadrazil
Biomedical Papers.2018; 162(4): 249. CrossRef
Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
Diabetes & Metabolism Journal.2018; 42(5): 415. CrossRef
Development and Validation of the Korean Diabetes Risk Score: A 10-Year National Cohort Study
Kyoung Hwa Ha, Yong-ho Lee, Sun Ok Song, Jae-woo Lee, Dong Wook Kim, Kyung-hee Cho, Dae Jung Kim
Diabetes & Metabolism Journal.2018; 42(5): 402. CrossRef
Evaluation of the association between sleep duration and tooth loss among Korean adults: data from the Korean National Health and Nutrition Examination Survey (KNHANES 2012–2014)
Kyungdo Han, Jun-Beom Park
BMJ Open.2018; 8(5): e018383. CrossRef
Impact of glycated hemoglobin (HbA1c) on identifying insulin resistance among apparently healthy individuals
Sarama Saha, Peter E. H. Schwarz
Journal of Public Health.2017; 25(5): 505. CrossRef
Trends in the pervasiveness of type 2 diabetes, impaired fasting glucose and co-morbidities during an 8-year-follow-up of nationwide Korean population
Junghyun Noh, Kyung-Do Han, Seung-Hyun Ko, Kyung Soo Ko, Cheol-Young Park
Scientific Reports.2017;[Epub] CrossRef
Efficacy and safety of sitagliptin/metformin fixed‐dose combination compared with glimepiride in patients with type 2 diabetes: A multicenter randomized double‐blind study
Sang Soo Kim, In Joo Kim, Kwang Jae Lee, Jeong Hyun Park, Young Il Kim, Young Sil Lee, Sung Chang Chung, Sang Jin Lee
Journal of Diabetes.2017; 9(4): 412. CrossRef
Periodontitis is associated with diabetic retinopathy in non-obese adults
Su Jeong Song, Seong-su Lee, Kyungdo Han, Jun-Beom Park
Endocrine.2017; 56(1): 82. CrossRef
Association between oral health behavior and periodontal disease among Korean adults
Kyungdo Han, Jun-Beom Park
Medicine.2017; 96(7): e6176. CrossRef
Prevalence and risk factors for reduced pulmonary function in diabetic patients: The Korea National Health and Nutrition Examination Survey
Hee Yeon Kim, Tae Seo Sohn, Hannah Seok, Chang Dong Yeo, Young Soo Kim, Jae Yen Song, Young Bok Lee, Dong-Hee Lee, Jae-Im Lee, Tae-Kyu Lee, Seong Cheol Jeong, Mihee Hong, Hiun Suk Chae
The Korean Journal of Internal Medicine.2017; 32(4): 682. CrossRef
Impaired Fasting Glucose Rate by Diabetes Family History
Eun-Hei Kim, Sang-Geun Bae, Keon-Yeop Kim, Yoon-ju Na
Journal of Health Informatics and Statistics.2017; 42(1): 63. CrossRef
Age threshold for moderate and severe periodontitis among Korean adults without diabetes mellitus, hypertension, metabolic syndrome, and/or obesity
Kyungdo Han, Jun-Beom Park
Medicine.2017; 96(33): e7835. CrossRef
Socioeconomic status is associated with global diabetes prevalence
Zhiye Xu, Dan Yu, Xueyao Yin, Fenping Zheng, Hong Li
Oncotarget.2017; 8(27): 44434. CrossRef
The Cutoff Value of HbA1c in Predicting Diabetes and Impaired Fasting Glucose
Seyoung Kwon, Youngak Na
The Korean Journal of Clinical Laboratory Science.2017; 49(2): 114. CrossRef
Effects of Lobeglitazone, a Novel Thiazolidinedione, on Bone Mineral Density in Patients with Type 2 Diabetes Mellitus over 52 Weeks
Soo Lim, Kyoung Min Kim, Sin Gon Kim, Doo Man Kim, Jeong-Taek Woo, Choon Hee Chung, Kyung Soo Ko, Jeong Hyun Park, Yongsoo Park, Sang Jin Kim, Hak Chul Jang, Dong Seop Choi
Diabetes & Metabolism Journal.2017; 41(5): 377. CrossRef
Association between underweight and tooth loss among Korean adults
In-Seok Song, Kyungdo Han, Jae-Jun Ryu, Jun-Beom Park
Scientific Reports.2017;[Epub] CrossRef
Outcomes and inequalities in diabetes from 2004/2005 to 2011/2012: English longitudinal study
Robert Fleetcroft, Miqdad Asaria, Shehzad Ali, Richard Cookson
British Journal of General Practice.2017; 67(654): e1. CrossRef
Discordance in the diagnosis of diabetes: Comparison between HbA1c and fasting plasma glucose
Lan T. Ho-Pham, Uyen D. T. Nguyen, Truong X. Tran, Tuan V. Nguyen, Petter Bjornstad
PLOS ONE.2017; 12(8): e0182192. CrossRef
Declining Incidence of Ischemic Stroke
Anne M. Vangen-Lønne, Tom Wilsgaard, Stein Harald Johnsen, Maja-Lisa Løchen, Inger Njølstad, Ellisiv B. Mathiesen
Stroke.2017; 48(3): 544. CrossRef
Association between temporomandibular disorders and obesity
Eunmi Rhim, Kyungdo Han, Kyoung-In Yun
Journal of Cranio-Maxillofacial Surgery.2016; 44(8): 1003. CrossRef
Trends of antidiabetic drug use in adult type 2 diabetes in Korea in 2002–2013
Seung-Hyun Ko, Dae-Jung Kim, Jong-Heon Park, Cheol-Young Park, Chang Hee Jung, Hyuk-Sang Kwon, Joong-Yeol Park, Kee-Ho Song, Kyungdo Han, Ki-Up Lee, Kyung-Soo Ko
Medicine.2016; 95(27): e4018. CrossRef
Prevalence and risk factors of periodontitis among adults with or without diabetes mellitus
Mihee Hong, Hee Yeon Kim, Hannah Seok, Chang Dong Yeo, Young Soo Kim, Jae Yen Song, Young Bok Lee, Dong-Hee Lee, Jae-Im Lee, Tae-Kyu Lee, Hyo-Suk Ahn, Yoon Ho Ko, Seong Cheol Jeong, Hiun Suk Chae, Tae Seo Sohn
The Korean Journal of Internal Medicine.2016; 31(5): 910. CrossRef
The Relationship between Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease Measured by Controlled Attenuation Parameter
Young Eun Chon, Kwang Joon Kim, Kyu Sik Jung, Seung Up Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Chae Yoon Chon, Jae Bock Chung, Kyeong Hye Park, Ji Cheol Bae, Kwang-Hyub Han
Yonsei Medical Journal.2016; 57(4): 885. CrossRef
Comparative Study on Self-care Behavior Related Factors for Good, Inadequate and Poor Glycemic Control Groups: Based on Variables from Theory of Planned Behavior, Habit, and Family support*
Jae-Kyoung Kim, Mee Ock Gu
Journal of Korean Academy of Fundamentals of Nursing.2016; 23(3): 245. CrossRef
Associations between the number of natural teeth and renal dysfunction
Hye Min Choi, Kyungdo Han, Yong Gyu Park, Jun-Beom Park
Medicine.2016; 95(34): e4681. CrossRef
Associations between the number of natural teeth in postmenopausal women and duration of lactation: The 2010–2012 Korea National Health and Nutrition Examination Survey
Kyungdo Han, Youngkyung Ko, Yong-Gyu Park, Jun-Beom Park
Maturitas.2016; 85: 73. CrossRef
Trends in Diabetes Incidence in the Last Decade Based on Korean National Health Insurance Claims Data
Sun Ok Song, Yong-ho Lee, Dong Wook Kim, Young Duk Song, Joo Young Nam, Kyoung Hye Park, Dae Jung Kim, Seok Won Park, Hyun Chul Lee, Byung-Wan Lee
Endocrinology and Metabolism.2016; 31(2): 292. CrossRef
Comparison of Age of Onset and Frequency of Diabetic Complications in the Very Elderly Patients with Type 2 Diabetes
Bong-Ki Lee, Sang-Wook Kim, Daehee Choi, Eun-Hee Cho
Endocrinology and Metabolism.2016; 31(3): 416. CrossRef
Emerging Role of Nitric Oxide and Heat Shock Proteins in Insulin Resistance
Marisa Nile Molina, León Ferder, Walter Manucha
Current Hypertension Reports.2016;[Epub] CrossRef
Association between Consumption of Coffee and the Prevalence of Periodontitis: The 2008–2010 Korea National Health and Nutrition Examination Survey
Kyungdo Han, Eunkyung Hwang, Jun-Beom Park, Alberto G Passi
PLOS ONE.2016; 11(7): e0158845. CrossRef
Cause-of-death statistics in the Republic of Korea, 2014
Hyun-Young Shin, Ji-Youn Lee, Juhwa Song, Seokmin Lee, Junghun Lee, Byeongsun Lim, Heyran Kim, Sun Huh
Journal of the Korean Medical Association.2016; 59(3): 221. CrossRef
Effect of Wheat Flour Noodles with Bombyx mori Powder on Glycemic Response in Healthy Subjects
Wanhee Suk, JiEun Kim, Do-Yeon Kim, Hyunjung Lim, Ryowon Choue
Preventive Nutrition and Food Science.2016; 21(3): 165. CrossRef
C-Peptide-Based Index Is More Related to Incident Type 2 Diabetes in Non-Diabetic Subjects than Insulin-Based Index
Jong-Dai Kim, Sung Ju Kang, Min Kyung Lee, Se Eun Park, Eun Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
Endocrinology and Metabolism.2016; 31(2): 320. CrossRef
Inhibition of advanced glycation end product formation by burdock root extract
Darye Lee, Choon Young Kim
Journal of Nutrition and Health.2016; 49(4): 233. CrossRef
Associations between the number of natural teeth in postmenopausal women and hormone replacement therapy
Kyungdo Han, Youngkyung Ko, Yong-Gyu Park, Jun-Beom Park
Maturitas.2016; 94: 125. CrossRef
Is an Oral Glucose Tolerance Test Still Valid for Diagnosing Diabetes Mellitus?
Dong-Lim Kim, Sun-Doo Kim, Suk Kyeong Kim, Sooyoun Park, Kee-Ho Song
Diabetes & Metabolism Journal.2016; 40(2): 118. CrossRef
Are We in the Same Risk of Diabetes Mellitus? Gender- and Age-Specific Epidemiology of Diabetes in 2001 to 2014 in the Korean Population
Bo Kyung Koo, Min Kyong Moon
Diabetes & Metabolism Journal.2016; 40(3): 175. CrossRef
Comparison of the clinical characteristics of diabetes mellitus diagnosed using fasting plasma glucose and haemoglobin A1c: The 2011 Korea National Health and Nutrition Examination Survey
Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Chang Beom Lee, Sung-Hee Ihm
Diabetes Research and Clinical Practice.2016; 113: 23. CrossRef
Excessive Consumption of Green Tea as a Risk Factor for Periodontal Disease among Korean Adults
Kyungdo Han, Eunkyung Hwang, Jun-Beom Park
Nutrients.2016; 8(7): 408. CrossRef
Laboratorydiagnosis of prediabetes
Grażyna Odrowąż-Sypniewska
Diagnostyka Laboratoryjna.2016; 52(1): 57. CrossRef
TRPV1 Gene Polymorphisms Are Associated with Type 2 Diabetes by Their Interaction with Fat Consumption in the Korean Genome Epidemiology Study
Sunmin Park, Xin Zhang, Na Ra Lee, Hyun-Seok Jin
Lifestyle Genomics.2016; 9(1): 47. CrossRef
Need for Diabetes Prevention Study
Ja Young Jeon, Dae Jung Kim
The Journal of Korean Diabetes.2015; 16(3): 161. CrossRef
New risk factors for obesity and diabetes: Environmental chemicals
Ja Young Jeon, Kyoung Hwa Ha, Dae Jung Kim
Journal of Diabetes Investigation.2015; 6(2): 109. CrossRef
Hospital Nurses' Pre-diabetes Knowledge, Performance and Expectation of Patient Education
Min Jung Kim, Misoon Song
Perspectives in Nursing Science.2015; 12(1): 33. CrossRef
Secular Changes in Prediabetes Indicators Among Older-Adult Americans, 1999−2010
Carl J. Caspersen, G. Darlene Thomas, Gloria L.A. Beckles, Kai McKeever Bullard
American Journal of Preventive Medicine.2015; 48(3): 253. CrossRef
Low transferrin saturation is associated with impaired fasting glucose and insulin resistance in the South Korean adults: the 2010 Korean National Health and Nutrition Examination Survey
R. J. Park, J. D. Moon
Diabetic Medicine.2015; 32(5): 673. CrossRef
Role of habitual physical activity in modulating vascular actions of insulin
Jaume Padilla, T. Dylan Olver, John P. Thyfault, Paul J. Fadel
Experimental Physiology.2015; 100(7): 759. CrossRef
Derivation and validation of an HbA1c optimal cutoff for diagnosing prediabetes in a South African mixed ancestry population
Annalise E. Zemlin, Tandi E. Matsha, Andre P. Kengne, Rajiv T. Erasmus
Clinica Chimica Acta.2015; 448: 215. CrossRef
Change in Corneal Biomechanical Parameters in Diabetes Mellitus
Yeon Ggoch Park, Jin Young Rhew, Kyu Ryong Choi
Journal of the Korean Ophthalmological Society.2015; 56(4): 567. CrossRef
New Directions in Chronic Disease Management
Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon
Endocrinology and Metabolism.2015; 30(2): 159. CrossRef
Insulin Initiation in Insulin-Naïve Korean Type 2 Diabetic Patients Inadequately Controlled on Oral Antidiabetic Drugs in Real-World Practice: The Modality of Insulin Treatment Evaluation Study
Sang Soo Kim, In Joo Kim, Yong Ki Kim, Kun Ho Yoon, Ho Young Son, Sung Woo Park, Yeon Ah Sung, Hong Sun Baek
Diabetes & Metabolism Journal.2015; 39(6): 481. CrossRef
New insights into insulin action and resistance in the vasculature
Camila Manrique, Guido Lastra, James R. Sowers
Annals of the New York Academy of Sciences.2014; 1311(1): 138. CrossRef
Current Status of Glycemic Control of Patients with Diabetes in Korea: The Fifth Korea National Health and Nutrition Examination Survey
Ja Young Jeon, Dae Jung Kim, Seung-Hyun Ko, Hyuk-Sang Kwon, Soo Lim, Sung Hee Choi, Chul Sik Kim, Jee Hyun An, Nan Hee Kim, Jong Chul Won, Jae Hyeon Kim, Bong-Yun Cha, Kee-Ho Song
Diabetes & Metabolism Journal.2014; 38(3): 197. CrossRef
It's Still Not Too Late to Make a Change: Current Status of Glycemic Control in Korea
Sang Yong Kim
Diabetes & Metabolism Journal.2014; 38(3): 194. CrossRef
Diabetes Update 2014 – das spannendste Diabetes-Update aller Zeiten
W.A. Scherbaum
Der Diabetologe.2014; 10(5): 363. CrossRef
Higher Prevalence and Awareness, but Lower Control Rate of Hypertension in Patients with Diabetes than General Population: The Fifth Korean National Health and Nutrition Examination Survey in 2011
Seung-Hyun Ko, Hyuk-Sang Kwon, Dae Jung Kim, Jae Hyeon Kim, Nan Hee Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Soo Lim, Sung Hee Choi, Kyungdo Han, Yong-Moon Park, Bong-Yun Cha
Diabetes & Metabolism Journal.2014; 38(1): 51. CrossRef
Association Between Alcohol Consumption and Periodontal Disease: The 2008 to 2010 Korea National Health and Nutrition Examination Survey
Jun‐Beom Park, Kyungdo Han, Yong‐Gyu Park, Youngkyung Ko
Journal of Periodontology.2014; 85(11): 1521. CrossRef
Glycaemic and haemoglobin A1c thresholds for detecting diabetic retinopathy: The fifth Korea National Health and Nutrition Examination Survey (2011)
Yong-Moon Park, Seung-Hyun Ko, Jung-Min Lee, Dae-Jung Kim, Dong-Joon Kim, Kyungdo Han, Julie K. Bower, Yu-Bae Ahn
Diabetes Research and Clinical Practice.2014; 104(3): 435. CrossRef
Diabetic Kidney Disease: From Epidemiology to Clinical Perspectives
Cheol Whee Park
Diabetes & Metabolism Journal.2014; 38(4): 252. CrossRef
Insulin Resistance and Skeletal Muscle Vasculature: Significance, Assessment and Therapeutic Modulators
Camila Manrique, James R. Sowers
Cardiorenal Medicine.2014; 4(3-4): 244. CrossRef
Metformin Based Dual-Combination Therapies in Drug Naïve Type 2 Diabetic Patients
Dong-Lim Kim
Diabetes & Metabolism Journal.2013; 37(6): 429. CrossRef

Predictive Clinical Parameters and Glycemic Efficacy of Vildagliptin Treatment in Korean Subjects with Type 2 Diabetes: Jin-Sun Chang, Juyoung Shin, Hun-Sung Kim, Kyung-Hee Kim, Jeong-Ah Shin, Kun-Ho Yoon, Bong-Yun Cha, Ho-Young Son, Jae-Hyoung Cho; Diabetes Metab J. 2013;37(1):72-80. Published online February 15, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.1.72

4,268 View
33 Download
2 Crossref

Abstract PDF PubReader

Background

The aims of this study are to investigate the glycemic efficacy and predictive parameters of vildagliptin therapy in Korean subjects with type 2 diabetes.

Methods

In this retrospective study, we retrieved data for subjects who were on twice-daily 50 mg vildagliptin for at least 6 months, and classified the subjects into five treatment groups. In three of the groups, we added vildagliptin to their existing medication regimen; in the other two groups, we replaced one of their existing medications with vildagliptin. We then analyzed the changes in glucose parameters and clinical characteristics.

Results

Ultimately, 327 subjects were analyzed in this study. Vildagliptin significantly improved hemoglobin A1c (HbA1c) levels over 6 months. The changes in HbA1c levels (ΔHbA1c) at month 6 were -2.24% (P=0.000), -0.77% (P=0.000), -0.80% (P=0.001), -0.61% (P=0.000), and -0.34% (P=0.025) for groups 1, 2, 3, 4, and 5, respectively, with significance. We also found significant decrements in fasting plasma glucose levels in groups 1, 2, 3, and 4 (P<0.05). Of the variables, initial HbA1c levels (P=0.032) and history of sulfonylurea use (P=0.026) were independently associated with responsiveness to vildagliptin treatment.

Conclusion

Vildagliptin was effective when it was used in subjects with poor glycemic control. It controlled fasting plasma glucose levels as well as sulfonylurea treatment in Korean type 2 diabetic subjects.

Citations

Citations to this article as recorded by

Predictive clinical parameters for the hemoglobin A1c-lowering effect of vildagliptin in Japanese patients with type 2 diabetes
Yukihiro Bando, Masayuki Yamada, Keiko Aoki, Hideo Kanehara, Azusa Hisada, Kazuhiro Okafuji, Daisyu Toya, Nobuyoshi Tanaka
Diabetology International.2014; 5(4): 229. CrossRef
The Efficacy of Vildagliptin in Korean Patients with Type 2 Diabetes
Jun Sung Moon, Kyu Chang Won
Diabetes & Metabolism Journal.2013; 37(1): 36. CrossRef

Effects of a 6-Month Exenatide Therapy on HbA1c and Weight in Korean Patients with Type 2 Diabetes: A Retrospective Cohort Study: Juyoung Shin, Jin-Sun Chang, Hun-Sung Kim, Sun-Hee Ko, Bong-Yun Cha, Ho-Young Son, Kun-Ho Yoon, Jae-Hyoung Cho; Diabetes Metab J. 2012;36(5):364-370. Published online October 18, 2012; DOI: https://doi.org/10.4093/dmj.2012.36.5.364

3,945 View
38 Download
10 Crossref

Abstract PDF PubReader

Background

While many studies have shown the good efficacy and safety of exenatide in patients with diabetes, limited information is available about exenatide in clinical practice in Korean populations. Therefore, this retrospective cohort study was designed to analyze the effects of exenatide on blood glucose level and body weight in Korean patients with type 2 diabetes mellitus.

Methods

We reviewed the records of the patients with diabetes who visited Seoul St. Mary's Hospital and for whom exenatide was prescribed from June 2009 to October 2011. After excluding subjects based on their race/ethnicity, medical history, whether or not they changed more than 2 kinds of oral hypoglycemic agents with exenatide treatment, loss to follow-up, or whether they stopped exenatide therapy within 6 months, a total of 52 subjects were included in the final analysis.

Results

The mean glycated hemoglobin (HbA1c) level and weight remarkably decreased from 8.5±1.7% to 6.7±1.0% (P<0.001) and from 82.3±15.8 kg to 78.6±16.3 kg (P<0.001), respectively. The multiple regression analysis indicated that the reduction in HbA1c level was significantly associated with a shorter duration of diabetes, a higher baseline HbA1c level, and greater weight reduction, whereas weight loss had no significant correlation with other factors. No severe adverse events were observed.

Conclusion

These results suggest that a 6-month exenatide injection therapy significantly improved patients' HbA1c levels and body weights without causing serious adverse effects in Korean patients with type 2 diabetes.

Citations

Citations to this article as recorded by

Recellularization via electroporation therapy of the duodenum combined with glucagon-like peptide 1 receptor agonist to replace insulin therapy in patients with type 2 diabetes: 12-month results of a first-in-human study
Celine B.E. Busch, Suzanne Meiring, Annieke C.G. van Baar, Frits Holleman, Max Nieuwdorp, Jacques J.G.H.M. Bergman
Gastrointestinal Endoscopy.2024;[Epub] CrossRef
Clinical and Genetic Predictors of Glycemic Control and Weight Loss Response to Liraglutide in Patients with Type 2 Diabetes
Artemis Kyriakidou, Angeliki V. Kyriazou, Theocharis Koufakis, Yiannis Vasilopoulos, Maria Grammatiki, Xanthippi Tsekmekidou, Iakovos Avramidis, Stefanos Baltagiannis, Dimitrios G. Goulis, Pantelis Zebekakis, Kalliopi Kotsa
Journal of Personalized Medicine.2022; 12(3): 424. CrossRef
Insulin receptor signaling and glucagon-like peptide 1 effects on pancreatic beta cells
Nunzia Caporarello, Cristina Parrino, Vincenzo Trischitta, Lucia Frittitta, Claudia Miele
PLOS ONE.2017; 12(8): e0181190. CrossRef
Exenatide versus Insulin Lispro Added to Basal Insulin in a Subgroup of Korean Patients with Type 2 Diabetes Mellitus
Kun-Ho Yoon, Elise Hardy, Jenny Han
Diabetes & Metabolism Journal.2017; 41(1): 69. CrossRef
Acarbose reduces body weight irrespective of glycemic control in patients with diabetes: results of a worldwide, non-interventional, observational study data pool
Oliver Schnell, Jianping Weng, Wayne H.-H. Sheu, Hirotaka Watada, Sanjay Kalra, Sidartawan Soegondo, Noriyuki Yamamoto, Rahul Rathod, Cheryl Zhang, Wladyslaw Grzeszczak
Journal of Diabetes and its Complications.2016; 30(4): 628. CrossRef
Determining Predictors of Early Response to Exenatide in Patients with Type 2 Diabetes Mellitus
Muhammad Khan, Jing Ouyang, Karen Perkins, Sunil Nair, Franklin Joseph
Journal of Diabetes Research.2015; 2015: 1. CrossRef
The Role of Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes: Understanding How Data Can Inform Clinical Practice in Korea
Seungjoon Oh, Suk Chon, Kyu Jeong Ahn, In-Kyung Jeong, Byung-Joon Kim, Jun Goo Kang
Diabetes & Metabolism Journal.2015; 39(3): 177. CrossRef
Tolerability, effectiveness and predictive parameters for the therapeutic usefulness of exenatide in obese, Korean patients with type 2 diabetes
Sun Ok Song, Kwang Joon Kim, Byung‐Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee
Journal of Diabetes Investigation.2014; 5(5): 554. CrossRef
From endocrine to rheumatism: do gut hormones play roles in rheumatoid arthritis?
C.-Y. Chen, C.-Y. Tsai
Rheumatology.2014; 53(2): 205. CrossRef
Early use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in Type 2 diabetes
Stuart A. Ross, Jane Ballantine
Current Medical Research and Opinion.2013; 29(12): 1617. CrossRef

Review

Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus in Korea: Seung-Hyun Ko, Bong-Yun Cha; Diabetes Metab J. 2012;36(1):6-12. Published online February 17, 2012; DOI: https://doi.org/10.4093/dmj.2012.36.1.6

5,356 View
95 Download
31 Crossref

Abstract PDF PubReader

Diabetic peripheral neuropathy (DPN), a common and troublesome complication in patients with type 2 diabetes mellitus (T2DM), contributes to a higher risk of diabetic foot ulcer and lower limb amputation. These situations can negatively impact the quality of life of affected individuals. Despite its high prevalence and clinical importance, most diabetes mellitus patients not only do not recognize the presence of diabetic neuropathy, but also do not report their symptoms to physicians or other health care providers. Therefore, DPN is usually under diagnosed and undertreated. For early detection and appropriate intervention for DPN, a careful history, physical with neurologic examination, and prompt treatment are needed in T2DM patients.

Citations

Citations to this article as recorded by

Pramipexole protects against diabetic neuropathy: Effect on oxidative stress, TLR4/IRAK-1/TRAF-6/NF-κB and downstream inflammatory mediators
Nada H. Eisa, Sahar A Helmy, Dalia H. El-Kashef, Mohamed El-Sherbiny, Nehal M. Elsherbiny
International Immunopharmacology.2024; 128: 111514. CrossRef
Diabetic peripheral neuropathy among adult type 2 diabetes patients in Adama, Ethiopia: health facility-based study
Yohannes Mekuria Negussie, Nardos Tilahun Bekele
Scientific Reports.2024;[Epub] CrossRef
Phenotypical characterization of exteroceptive sensation and pain symptoms on diabetic patients
Inaeh de Paula Oliveira, Victória Regina da Silva Oliveira, Heloísa Alonso‐Matielo, Beatriz Magalhães Eng, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Milena Cristina Dias Calsaverini, Fernando de Quadros Ribeiro, José Deney Alves Araújo, Helder T
Pain Practice.2024; 24(5): 724. CrossRef
New Horizons in Diabetic Neuropathies: An Updated Review on their Pathology, Diagnosis, Mechanism, Screening Techniques, Pharmacological, and Future Approaches
Namra Aziz, Biswajit Dash, Pranay Wal, Prachi Kumari, Poonam Joshi, Ankita wal
Current Diabetes Reviews.2024;[Epub] CrossRef
A Probiotic Mixture Decreases Neuropathy and Oxidative Stress Markers in Diabetic Rats
Mohammad Shabani, Elham Hassanpour, Fatemeh Aghighi, Mojgan Mohammadifar, Fereshteh Bahmani, Sayyed Alireza Talaei
OBM Neurobiology.2024; 08(03): 1. CrossRef
Time to diabetic neuropathy and its predictors among adult type 2 diabetes mellitus patients in Amhara regional state Comprehensive Specialized Hospitals, Northwest Ethiopia, 2022: A retrospective follow up study
Sharie Tantigegn, Atsede Alle Ewunetie, Moges Agazhe, Abiot Aschale, Muluye Gebrie, Gedefaw Diress, Bekalu Endalew Alamneh, James Nyirenda
PLOS ONE.2023; 18(4): e0284568. CrossRef
Nutraceuticals: A Promising Approach Towards Diabetic Neuropathy
Sakshi Bajaj, Sumeet Gupta
Endocrine, Metabolic & Immune Disorders - Drug Targets.2023; 23(5): 581. CrossRef
Role of oxidative stress in diabetes-induced complications and their management with antioxidants
Hasandeep Singh, Rajanpreet Singh, Arshdeep Singh, Harshbir Singh, Gurpreet Singh, Sarabjit Kaur, Balbir Singh
Archives of Physiology and Biochemistry.2023; : 1. CrossRef
Diabetic Peripheral Neuropathy Associated with Cardiovascular Risk Factors and Glucagon-Like Peptide-1 Concentrations Among Newly Diagnosed Patients with Type 2 Diabetes Mellitus
Tuan Dinh Le, Nga Phi Thi Nguyen, Thi Thanh Hoa Tran, Thuc Luong Cong, Lan Ho Thi Nguyen, Binh Do Nhu, Son Tien Nguyen, Manh Van Ngo, Trung Hoa Dinh, Hien Thi Nguyen, Kien Trung Nguyen, Cuong Duc Le
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 35. CrossRef
The relation between serum uric acid levels and diabetic peripheral neuropathy in type 2 diabetes in Guilan, north of Iran
Haniye Sadat Fayazi, Maryam Yaseri, Seyyede Sahere Mortazavi, Zahra Sharifhassan, Ali-Sina Assadinia
BMC Endocrine Disorders.2022;[Epub] CrossRef
A comparative evaluation of cardiac and neurological safety status of two commonly used oral hypoglycaemic agents in T2-DM Swiss albino mice model
Md. Ohidur Rahman, Shaheen Ahmed, Tanoy Mazumder, Md. Abdus Salam, Prodip Kumar Baral, Md. Faruk Rana, Shuvo Mitra, Sayem Hossain, Rubiya Rahman, Md. Saddam Hussain
Metabolism Open.2022; 14: 100191. CrossRef
Increased expression of BDNF and inflammatory biomarkers in type 2 diabetes-related claustrophobia: A case report
Ankita Srivastava, BashairM Mussa, Salahedeen Abusnana
Advances in Biomedical and Health Sciences.2022; 1(3): 175. CrossRef
Drug repurposing – A search for novel therapy for the treatment of diabetic neuropathy
Arpita Paul, Mohit Kumar, Parikshit Das, Nilayan Guha, Mithun Rudrapal, Md. Kamaruz Zaman
Biomedicine & Pharmacotherapy.2022; 156: 113846. CrossRef
Comparison of Neutrophyl Lymphocyte Ratio and Nerve Conduction Study Between Male Type 2 Diabetes Mellitus With or Without Peripheral Neuropathy Complication
Martha Kurnia Kusumawardani, Surdiana, I Putu Alit Pawana, Sony Wibisono
Indonesian Journal of Physical Medicine and Rehabilitation.2022; 11(01): 33. CrossRef
Is health related quality of life influenced by diabetic neuropathic pain among type II diabetes mellitus patients in Ethiopia?
Hiwot Degu, Abigiya Wondimagegnehu, Yared Mamushet Yifru, Ayele Belachew, Rayaz A. Malik
PLOS ONE.2019; 14(2): e0211449. CrossRef
Improving vibration perception in a patient with type 2 diabetes and sensory peripheral neuropathy
Liezel Ennion, Juha Hijmans
South African Journal of Physiotherapy.2019;[Epub] CrossRef
Fas-mediated apoptosis and peripheral polyneuropathy in type 2 diabetes mellitus
Mowaffak M. Abd Elhameed, Noha A. Elsawy, Magdy H. Zekry Mgalaa, Sarah S. El-Tawab, Reham A. Abo Elwafa, Marwa R. Abd Elfadeel
Egyptian Rheumatology and Rehabilitation.2019; 46(4): 321. CrossRef
The Necessity of the Simple Tests for Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus Patients without Neuropathic Symptoms in Clinical Practice
Jung Hwan Park, Dong Sun Kim
Diabetes & Metabolism Journal.2018; 42(5): 442. CrossRef
Transplantation of human mobilized mononuclear cells improved diabetic neuropathy
Se Hee Min, Jung Hee Kim, Yu Mi Kang, Seung Hak Lee, Byung-Mo Oh, Kyou-Sup Han, Meihua Zhang, Hoe Suk Kim, Woo Kyung Moon, Hakmo Lee, Kyong Soo Park, Hye Seung Jung
Journal of Endocrinology.2018; 239(3): 277. CrossRef
Do we underestimate influences of diabetic mononeuropathy or polyneuropathy on hand functional performance and life quality?
Chien‐Ju Yang, Hsiu‐Yun Hsu, Chieh‐Hsiang Lu, Yen‐Li Chao, Haw‐Yen Chiu, Li‐Chieh Kuo
Journal of Diabetes Investigation.2018; 9(1): 179. CrossRef
Response: The Necessity of the Simple Tests for Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus Patients without Neuropathic Symptoms in Clinical Practice (Diabetes Metab J 2018;42:442–6)
Jung Hwan Park, Dong Sun Kim
Diabetes & Metabolism Journal.2018; 42(6): 546. CrossRef
Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets
Saikat Dewanjee, Sonjit Das, Anup Kumar Das, Niloy Bhattacharjee, Anjum Dihingia, Tarun K. Dua, Jatin Kalita, Prasenjit Manna
European Journal of Pharmacology.2018; 833: 472. CrossRef
ANTIOXIDANT STATUS IN DIABETIC NEUROPATHY
Giriraja Vrushabaiah Kanakapura, Pavitra Chandrashekar Bangalore, Bindumathi Pula Lakshmi
Journal of Evidence Based Medicine and Healthcare.2017; 4(78): 4588. CrossRef
Association of diabetic vascular complications with poor sleep complaints
Ling-Ling Meng, Ying Liu, Rui-Na Geng, Yun-Zhao Tang, Dai-Qing Li
Diabetology & Metabolic Syndrome.2016;[Epub] CrossRef
Response: Cardiovascular Disease Predicts Severe Hypoglycemia in Patients with Type 2 Diabetes (Diabetes Metab J 2015;39:498-506)
Jae-Seung Yun, Yu-Bae Ahn
Diabetes & Metabolism Journal.2016; 40(1): 85. CrossRef
Antioxidant Strategies in the Management of Diabetic Neuropathy
Ayodeji Babatunde Oyenihi, Ademola Olabode Ayeleso, Emmanuel Mukwevho, Bubuya Masola
BioMed Research International.2015; 2015: 1. CrossRef
Association of depression and sleep quality with complications of type 2 diabetes in geriatric patients
Zeynel Abidin Öztürk, Yusuf Yesil, Mehmet Emin Kuyumcu, Esen Savas, Özhan Uygun, Zeynel Abidin Sayıner, Yalçın Kepekçi
Aging Clinical and Experimental Research.2015; 27(4): 533. CrossRef
Incidence trends and associated factors of diabetes mellitus in Korean children and adolescents: a retrospective cohort study in Busan and Gyeongnam
Jung Hyun Lee, Yu-Mi Kim, Min Jung Kwak, Su Yung Kim, Hyun-Ji Kim, Chong Kun Cheon, Woo Yeong Chung, Im-Jeong Choi, Su Young Hong, Hee Won Chueh, Jae-Ho Yoo
Annals of Pediatric Endocrinology & Metabolism.2015; 20(4): 206. CrossRef
Current Status of Management in Type 2 Diabetes Mellitus at General Hospitals in South Korea
Jin-Hee Jung, Jung-Hwa Lee, Jin-Won Noh, Jeong-Eun Park, Hee-Sook Kim, Joo-Wha Yoo, Bok-Rye Song, Jeong-rim Lee, Myeong-Hee Hong, Hyang-Mi Jang, Young Na, Hyun-Joo Lee, Jeong-Mi Lee, Yang-Gyo Kang, Sun-Young Kim, Kang-Hee Sim
Diabetes & Metabolism Journal.2015; 39(4): 307. CrossRef
Diabetic Peripheral Neuropathy in Ambulatory Patients with Type 2 Diabetes in a General Hospital in a Middle Income Country: A Cross-Sectional Study
María de los Angeles Lazo, Antonio Bernabé-Ortiz, Miguel E. Pinto, Ray Ticse, German Malaga, Katherine Sacksteder, J. Jaime Miranda, Robert H. Gilman, Leighton R. James
PLoS ONE.2014; 9(5): e95403. CrossRef
Monochromatic Infrared Photo Energy in Diabetic Peripheral Neuropathy
Tarek A. Ammar
ISRN Rehabilitation.2012; 2012: 1. CrossRef

First
Prev
Page of 1
Next
Last

Search