Diabetes & Metabolism Journal

Volume 46(1); January 2022

Special Editorial

Diabetes and Metabolism Journal in 2022: The Flywheel Effect for DMJ: Kyung Mook Choi; Diabetes Metab J. 2022;46(1):1-2. Published online January 27, 2022; DOI: https://doi.org/10.4093/dmj.2021.0348

7,852 View
196 Download
1 Web of Science
1 Crossref

PDF PubReader ePub

Citations

Citations to this article as recorded by

Mulberry leaf ameliorate STZ induced diabetic rat by regulating hepatic glycometabolism and fatty acid β-oxidation
Bohan Lv, Siyuan Liu, Yaqi Li, Zhigang Li, Yongcheng An, Changhao He, Huilin Zhang, Yan Huang, Wanxin Fu, Quantao Ma, Baosheng Zhao
Frontiers in Pharmacology.2024;[Epub] CrossRef

Reviews

Metabolic Risk/Epidemiology
Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications: Joon Ho Moon, Hak Chul Jang; Diabetes Metab J. 2022;46(1):3-14. Published online January 27, 2022; DOI: https://doi.org/10.4093/dmj.2021.0335

23,186 View
1,233 Download
124 Web of Science
133 Crossref

Graphical Abstract Abstract PDF PubReader ePub

Gestational diabetes mellitus (GDM) is the most common complication during pregnancy and is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. GDM is associated with adverse pregnancy outcomes and long-term offspring and maternal complications. For GDM screening and diagnosis, a two-step approach (1-hour 50 g glucose challenge test followed by 3-hour 100 g oral glucose tolerance test) has been widely used. After the Hyperglycemia and Adverse Pregnancy Outcome study implemented a 75 g oral glucose tolerance test in all pregnant women, a one-step approach was recommended as an option for the diagnosis of GDM after 2010. The one-step approach has more than doubled the incidence of GDM, but its clinical benefit in reducing adverse pregnancy outcomes remains controversial. Long-term complications of mothers with GDM include type 2 diabetes mellitus and cardiovascular disease, and complications of their offspring include childhood obesity and glucose intolerance. The diagnostic criteria of GDM should properly classify women at risk for adverse pregnancy outcomes and long-term complications. The present review summarizes the strengths and weaknesses of the one-step and two-step approaches for the diagnosis of GDM based on recent randomized controlled trials and observational studies. We also describe the long-term maternal and offspring complications of GDM.

Citations

Citations to this article as recorded by

Quality of Life in Women With Gestational Diabetes Mellitus and Treatment Satisfaction Upon Intermittently Scanned Continuous Glucose Monitoring
Sookyung Won, Hyeon Ji Kim, Jee Yoon Park, Kyung Joon Oh, Sung Hee Choi, Hak Chul Jang, Joon Ho Moon
Journal of Korean Medical Science.2025;[Epub] CrossRef
Gestational diabetes mellitus-derived miR-7-19488 targets PIK3R2 mRNA to stimulate the abnormal development and maturation of offspring-islets
Chunxue Xu, Linhai Zou, Li Wang, Wenshan Lv, Xiangju Cao, Xinyu Jia, Yuan Wang, Guohui Jiang, Lixia Ji
Life Sciences.2025; 363: 123369. CrossRef
How Do Maternal Gestational Diabetes and Other Concomitant Maternal Factors Determine the Perinatal Outcomes of Pregnancy?—A Retrospective Analysis
Karolina Karcz, Barbara Królak-Olejnik
Nutrients.2025; 17(1): 177. CrossRef
Blood Cells Parameters in Second Trimester of Pregnancy and Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis
Vida Ghasemi, Mojdeh Banaei, Zahra Kiani, Fahimeh Ramezani Tehrani, Marzieh Saei Ghare Naz
Endocrinology, Diabetes & Metabolism.2025;[Epub] CrossRef
Gut Microbiome-Derived Metabolites and Their Impact on Gene Regulatory Networks in Gestational Diabetes
Sarvesh Sabarathinam, Akash Jayaraman, Ramesh Venkatachalapathy
The Journal of Steroid Biochemistry and Molecular Biology.2025; : 106674. CrossRef
Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study
Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Yuichiro Miura, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima
Journal of Diabetes Investigation.2025;[Epub] CrossRef
Prophylactic administration of metformin reduces gestational diabetes mellitus incidence in the high-risk populations: a meta-analysis
Hui Yu, Jinling Sun, Honglei Hu
Irish Journal of Medical Science (1971 -).2024; 193(1): 199. CrossRef
Association of dietary inflammatory index with risk of gestational diabetes mellitus and preeclampsia: a systematic review and meta-analysis
Li Hong, Liyuan Zhu, Jinru Zhang, Yueqi Fu, Xiaoyan Qi, Mei Zhao
British Journal of Nutrition.2024; 131(1): 54. CrossRef
Ferritin and iron supplements in gestational diabetes mellitus: less or more?
Tianlian Li, Jingfan Zhang, Ping Li
European Journal of Nutrition.2024; 63(1): 67. CrossRef
Comparing the screening methods for gestational diabetes mellitus before and during the COVID‐19 pandemic: A systematic review
Xingge Sun, Clare McKeaveney, Helen Noble, Hannah O’Hara, Oliver Perra
Journal of Diabetes Investigation.2024; 15(4): 500. CrossRef
Protective Effects of Paeoniflorin Against Inflammation and Oxidative Stress in Rats with Gestational Diabetes Mellitus via Inhibiting the RhoA/ROCK Signaling Pathway
Cheng kun Yuan, Yan Gao, Jinglu Yu, Limin Peng
Revista Brasileira de Farmacognosia.2024; 34(3): 536. CrossRef
METTL14‐mediated lncRNA XIST silencing alleviates GDM progression by facilitating trophoblast cell proliferation and migration via the miR‐497‐5p/FOXO1 axis
Yanchuan Li, Yanfeng Liu, Xiao Yao, Haili Wang, Ziyun Shi, Meiqing He
Journal of Biochemical and Molecular Toxicology.2024;[Epub] CrossRef
Evaluation of insulin secretion and insulin sensitivity in pregnant women: Application value of simple indices
Shuying Ren, Dan Wu, Ping Li
Clinica Chimica Acta.2024; 554: 117753. CrossRef
ATP5me alleviates high glucose-induced myocardial cell injury
Qingsha Hou, Fang Yan, Xiuling Li, Huanling Liu, Xiang Yang, Xudong Dong
International Immunopharmacology.2024; 129: 111626. CrossRef
Aberrant NK cell profile in gestational diabetes mellitus with fetal growth restriction
Yujing Xiong, Yazhen Wang, Mengqi Wu, Shuqiang Chen, Hui Lei, Hui Mu, Haikun Yu, Yongli Hou, Kang Tang, Xutao Chen, Jie Dong, Xiaohong Wang, Lihua Chen
Frontiers in Immunology.2024;[Epub] CrossRef
Maternal Diabetes and Risk of Hypospadias: A Systemic Review and Meta-Analysis
Zhiyuan Liu, Chengjun Yu, Shuhan Yang, Jin Luo, Jie Zhang, Xiao Wang, Chun Wei, Qinlin Shi, Yi Hua, Xing Liu, Guanghui Wei
Urologia Internationalis.2024; 108(2): 108. CrossRef
Maternal birth weight as an indicator of early and late gestational diabetes mellitus: The Japan Environment and Children's Study
Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima
Journal of Diabetes Investigation.2024; 15(6): 751. CrossRef
Perinatal characteristics and pregnancy outcomes of advanced maternal age women with gestational diabetes mellitus: A retrospective cohort study
Chen Jiang, Haiyan Wen, Tingting Hu, Yanfei Liu, Xiaoqing Dai, Yiming Chen
Health Science Reports.2024;[Epub] CrossRef
Phenotypic characterisation of regulatory T cells in patients with gestational diabetes mellitus
Ya-nan Zhang, Qin Wu, Yi-hui Deng
Scientific Reports.2024;[Epub] CrossRef
Healthy behaviors and gestational diabetes mellitus in an Iranian setting: A cross-sectional study
Maryam Zare, Afrouz Mardi, Paria Yeghanenia, Daniel Hackett
Medicine.2024; 103(9): e36431. CrossRef
Post‐load glucose is a stronger predictor of adverse pregnancy outcomes than first‐trimester HbA1c in women without gestational diabetes
Shahin Keshtkar Rajabi, Elham Toghraee, Golnoosh Nejatipour
Journal of Diabetes Investigation.2024; 15(7): 914. CrossRef
Triglyceride-glucose index in early pregnancy predicts the risk of gestational diabetes: a prospective cohort study
Yufeng Guo, Junwen Lu, Mailiman Bahani, Guifeng Ding, Lei Wang, Yuxia Zhang, Huanmei Zhang, Chengyao Liu, Lijun Zhou, Xiaolan Liu, Fangshen Li, Xiaoli Wang, Hong Ding
Lipids in Health and Disease.2024;[Epub] CrossRef
A study on behavior, diet patterns and physical activity among selected GDM and non-GDM women in south India
S Sindhu, S Uma Mageshwari
Journal of Diabetology.2024; 15(1): 86. CrossRef
The Implication of Diabetes-Specialized Nurses in Aiming for the Better Treatment and Management of Patients with Diabetes Mellitus: A Brief Narrative Review
Yefang Zhu, Hongmei Zhang, Ying Xi, Hongli Zhu, Yan Lu, Xue Luo, Zhangui Tang, Hong Lei
Diabetes Therapy.2024; 15(5): 917. CrossRef
Triglyceride-glucose index: A promising biomarker for predicting risks of adverse pregnancy outcomes in Hangzhou, China
Jinghua Zhang, Binbin Yin, Ya Xi, Yongying Bai
Preventive Medicine Reports.2024; 41: 102683. CrossRef
Associations of education attainment with gestational diabetes mellitus and the mediating effects of obesity: A Mendelian randomization study
Xiaoyan Wang, Ying Lan, Na Li, Jinfeng Gao, Dejiao Meng, Shuchuan Miao
Heliyon.2024; 10(7): e29000. CrossRef
Quality assessment of videos on social media platforms related to gestational diabetes mellitus in China: A cross-section study
Qin-Yu Cai, Jing Tang, Si-Zhe Meng, Yi Sun, Xia Lan, Tai-Hang Liu
Heliyon.2024; 10(7): e29020. CrossRef
One abnormal value in oral glucose tolerance test during pregnancy and type 2 diabetes risk: Insights from a 5-Year Follow-Up study
Rawia Hussein-Aro, Esther Maor-Sagie, Yoel Toledano, Mordechai Hallak, Rinat Gabbay-Benziv
Diabetes Research and Clinical Practice.2024; 211: 111659. CrossRef
Assessment of the Level of Knowledge About Risk Factors, Prevention, and Treatment of Gestational Diabetes Mellitus in a Community Sample From Saudi Arabia
Suzan A Morsy, Ayat M Tawfik, Samar Y Badayyan, Lameer K Shaikh, Shaden AzizKhan, AlKhansaa A Zakari
Cureus.2024;[Epub] CrossRef
Genetic Susceptibility, Mendelian Randomization, and Nomogram Model Construction of Gestational Diabetes Mellitus
Qiulian Liang, Ming Li, Gongchen Huang, Ruiqi Li, Linyuan Qin, Ping Zhong, Xuekun Xing, Xiangyuan Yu
The Journal of Clinical Endocrinology & Metabolism.2024; 109(11): 2802. CrossRef
Study on the regulation of trophoblast activity by abnormally expressed hsa_circ_0024838/miR-543/HIF1A in patients with gestational diabetes mellitus
Qian Liu, Juan Gui, Lianzhi Wu
Placenta.2024; 151: 27. CrossRef
Association between sleep duration during pregnancy and gestational diabetes mellitus: a systematic review and meta-analysis
Yuandong Li, Chao Liang, Cui Wu, Zheng Nan
Frontiers in Medicine.2024;[Epub] CrossRef
Ultrasonographic diagnosis of fetal hemodynamic parameters in pregnant women with diabetes mellitus in the third trimester of pregnancy
Dongmei Cai, Su Yan
Heliyon.2024; 10(11): e30352. CrossRef
Gestational diabetes mellitus and development of intergenerational non-alcoholic fatty liver disease (NAFLD) after delivery: a systematic review and meta-analysis
Ru Xun Foo, Jenny Junyi Ma, Ruochen Du, George Boon Bee Goh, Yap Seng Chong, Cuilin Zhang, Ling-Jun Li
eClinicalMedicine.2024; 72: 102609. CrossRef
Perceptions of Chinese women with a history of gestational diabetes regarding health behaviors and related factors: a directed qualitative content analysis
Xiaoxia Ma, Yun Yang, Shuhua Qian, Yan Ding, Qiping Lin, Na Wang
BMC Public Health.2024;[Epub] CrossRef
Associations of serum D-dimer and glycosylated hemoglobin levels with third-trimester fetal growth restriction in gestational diabetes mellitus
Ying Zhang, Teng Li, Chao-Yan Yue, Yun Liu
World Journal of Diabetes.2024; 15(5): 914. CrossRef
Characterizing the Dynamic Expression of C1q/TNF-α-Related Protein 6 (CTRP6) during Pregnancy in Humans and Mice with Gestational Diabetes Mellitus
Jianan Jiang, Shuangyu Wei, Miao Chen, Yutian Tan, Zhao Yang, Guiying Yang, Weijie Feng, Zhen Han, Xiaojing Wei, Xiao Luo
Biomedicines.2024; 12(5): 1128. CrossRef
Influence of mHealth-Based Lifestyle Interventions on Symptoms of Anxiety and Depression of Women With Gestational Diabetes: A Meta-Analysis
Rong Liao, Yamin Li, Hui Yang, Yaoyue Luo
Clinical Nursing Research.2024; 33(6): 448. CrossRef
Association of VDR gene variant rs2228570-FokI with gestational diabetes mellitus susceptibility in Arab women
Maysa Alzaim, Mohammed G.A. Ansari, Abeer A. Al-Masri, Malak N.K. Khattak, Abir Alamro, Amani Alghamdi, Amal Alenad, Majed Alokail, Omar S. Al-Attas, Ahmad G. Al-Zahrani, Nasser M. Al-Daghri
Heliyon.2024; 10(11): e32048. CrossRef
Placental Expression of Glucose and Zinc Transporters in Women with Gestational Diabetes
Łukasz Ustianowski, Michał Czerewaty, Kajetan Kiełbowski, Estera Bakinowska, Maciej Tarnowski, Krzysztof Safranow, Andrzej Pawlik
Journal of Clinical Medicine.2024; 13(12): 3500. CrossRef
Development and validation of gestational diabetes mellitus health literacy scale
Ruting Gu, Tong Sun, Yueshuai Pan, Jingyuan Wang, Qianqian Li, Yan Zhang, Yalin Tang, Haiqing Zhou, Lili Wei
Patient Education and Counseling.2024; 127: 108365. CrossRef
Efectele placentare ale rezistenţei la insulină în sarcinile complicate cu diabet zaharat gestaţional
Ionescu Gabriela, Marina Nicolae-Gabriel, Scurtu Francesca, Dorneanu Denisa, Edu Mihnea-Dan, Mateescu Radu-Nicolae, Mihaela Plotogea, Antoine Edu, Claudia Mehedinţu, Noditi Aniela
Obstetrica şi Ginecologia.2024; 2(73): 74. CrossRef
The problem of diabetes mellitus in obstetrics
E.V. Popova-Petrosyan, A.A. Dovgan’, E.R. Kulieva
Russian Bulletin of Obstetrician-Gynecologist.2024; 24(3): 25. CrossRef
Second‐trimester triglyceride‐glucose index to predict adverse outcomes in women with gestational diabetes mellitus: A retrospective multicenter cohort study
Xueqi Bai, Qingyi Zhu, Wenli Wang, Sutong Kan, Shiman Hu, Runrun Hao, Shanshan Wang, Zhonghua Shi
Journal of Diabetes Investigation.2024; 15(10): 1489. CrossRef
Therapeutic effect of Momordica charantia on cardiomyopathy in a diabetic maternal rat model
Shaimaa M. Elnahas, Hend Abd El‐Halim Mansour, Mamdouh R. El‐Sawi, Amoura M. Abou‐El‐Naga
Journal of Experimental Zoology Part A: Ecological and Integrative Physiology.2024; 341(9): 977. CrossRef
Functional genetic variants and susceptibility and prediction of gestational diabetes mellitus
Gongchen Huang, Yan Sun, Ruiqi Li, Lei Mo, Qiulian Liang, Xiangyuan Yu
Scientific Reports.2024;[Epub] CrossRef
Early Methylglyoxal Exposure Leads to Worsened Cardiovascular Function in Young Rats
Marcos Divino Ferreira-Junior, Keilah Valéria N. Cavalcante, Jaqueline M. Costa, Amanda S. M. Bessa, Andreia Amaro, Carlos Henrique de Castro, Carlos Henrique Xavier, Sónia Silva, Diogo A. Fonseca, Paulo Matafome, Rodrigo Mello Gomes
Nutrients.2024; 16(13): 2029. CrossRef
The prevalence of gestational diabetes among underweight and normal weight women worldwide: a scoping review
Emily S. Gitlin, Michelle Demetres, Arthi Vaidyanathan, Nicole Palmer, Hannah Lee, Sabrina Loureiro, Eman Radwan, Abigail Tuschman, Jyoti Mathad, Puja Chebrolu
Frontiers in Clinical Diabetes and Healthcare.2024;[Epub] CrossRef
Metformin administration during pregnancy tends to reduce the risk of gestational diabetes mellitus and improve pregnancy outcomes in previously infertile women with polycystic ovary syndrome who become pregnant
Huamei Liu, Yajia Liu, Changhe Wei, Shoujiu Zhang, Yanjie Xu
Irish Journal of Medical Science (1971 -).2024; 193(6): 2843. CrossRef
Longitudinal integrative cell-free DNA analysis in gestational diabetes mellitus
Zhuangyuan Tang, Shuo Wang, Xi Li, Chengbin Hu, Qiangrong Zhai, Jing Wang, Qingshi Ye, Jinnan Liu, Guohong Zhang, Yuanyuan Guo, Fengxia Su, Huikun Liu, Lingyao Guan, Chang Jiang, Jiayu Chen, Min Li, Fangyi Ren, Yu Zhang, Minjuan Huang, Lingguo Li, Haiqian
Cell Reports Medicine.2024; 5(8): 101660. CrossRef
Dual-mode detection of glucose based on pistol-like DNAzyme-mediated exonuclease-assisted signal cycle
Huiying Lu, Xiaofeng Wang
BioTechniques.2024; 76(9): 415. CrossRef
2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of the Korean Diabetes Association
Jun Sung Moon, Shinae Kang, Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, Yoon Ju Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang
Diabetes & Metabolism Journal.2024; 48(4): 546. CrossRef
Metformin inhibits OCT3-mediated serotonin transport in the placenta
Veronika Vachalova, Fiona Kumnova, Tetiana Synova, Kasin Yadunandam Anandam, Cilia Abad, Rona Karahoda, Frantisek Staud
Biomedicine & Pharmacotherapy.2024; 179: 117399. CrossRef
Effects of multidimensional exercise management on self-efficacy, blood glucose control, and delivery outcomes in pregnant women with gestational diabetes mellitus
Ying He, Xin Liu, Xiali Yang
Frontiers in Physiology.2024;[Epub] CrossRef
Letter to the Editor: Comment on “The association between prepregnancy dietary fatty acids and risk of gestational diabetes mellitus: A prospective cohort study”
Joaci Pereira dos Santos Júnior, Erika Vanesa Cadena-Burbano, Raul Manhães-de-Castro, Ana Elisa Toscano
Clinical Nutrition ESPEN.2024; 63: 694. CrossRef
Role of the "Ana Goitia" diabetes day hospital in the reduction of maternal and infant morbimortality
Cecilia Noelia Ramos, Estela Mercedes Acosta
SCT Proceedings in Interdisciplinary Insights and Innovations.2024; 2: 348. CrossRef
Lysophosphatidylcholine Impairs the Mitochondria Homeostasis Leading to Trophoblast Dysfunction in Gestational Diabetes Mellitus
Shao-Chi Hung, Te-Fu Chan, Hsiu-Chuan Chan, Chia-Ying Wu, Mei-Lin Chan, Jie-Yang Jhuang, Ji-Qin Tan, Jia-Bin Mei, Shi-Hui Law, Vinoth Kumar Ponnusamy, Hua-Chen Chan, Liang-Yin Ke
Antioxidants.2024; 13(8): 1007. CrossRef
Effect of High Glucose on Embryological Development of Zebrafish, Brachyodanio, Rerio through Wnt Pathway
Ebony Thompson, Justin Hensley, Renfang Song Taylor
International Journal of Molecular Sciences.2024; 25(17): 9443. CrossRef
Periodontitis and diabetes in pregnant rats: Maternal-fetal outcomes
Samuel Santos Souza, Larissa Lopes Cruz, Amanda Munnick Alves-Reis, Vanessa Queiros Costa, Rafaianne Queiroz Moraes-Souza, Débora Cristina Damasceno, Gustavo Tadeu Volpato
Heliyon.2024; 10(17): e37394. CrossRef
MODULAÇÃO DA MICROBIOTA INTESTINAL NO DIABETES MELLITUS GESTACIONAL: ALVO POTENCIAL TERAPÊUTICO NA ATENUAÇÃO DOS DESFECHOS ADVERSOS MATERNOS E FETAIS
Rafaela da Silva Rocha, Adrielly Suely Santos Pereira, Marília Oliveira Fonseca Goulart, Elaine Luiza Santos Soares de Mendonça, Alane Cabral Menezes de Oliveira
Revista Contemporânea.2024; 4(9): e5677. CrossRef
Gestational diabetes mellitus: ensuring healthy futures
Harriet D Morgan, Malak Hamza, Amy E Morrison, Cathy Campbell, Caroline Borg Cassar, Sheena Thayyil, Claire L Meek
British Journal of Midwifery.2024; 32(10): 552. CrossRef
Characteristics of Glucose-Lipid Metabolism in Early Pregnancy Among Overweight and Obese Women and Their Predictive Value for Gestational Diabetes Mellitus
Xia Chen, Jianmin Zhang, Yuanru Tang, Yan Zhang, Ziwen Ma, Yifan Hu
Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 3711. CrossRef
Effects of Three Exercise Interventions on Pregnancy and Neonatal Outcomes in Chinese Women with Gestational Diabetes Mellitus: A Prospective Cohort Study
Yingchun Zeng, Xiaohui Meng, Meiling Wen, Yin Qin, Xiaorong Wang, Xia Dai, Qiuhong Huang
Clinical and Experimental Obstetrics & Gynecology.2024;[Epub] CrossRef
Insulin aspart plus high-dose vitamin D supplementation for gestational diabetes mellitus: analysis of efficacy and risk factors for maternal and infant outcomes
Huiying Qiu
American Journal of Translational Research.2024; 16(8): 4200. CrossRef
Influencing factors of glycemic control in singleton pregnancies complicated by gestational diabetes mellitus in western China: A retrospective study
Jiani Zhang, Chihui Mao, Qi Cao, Guiqiong Huang, Xiaodong Wang
Medicine.2024; 103(38): e39853. CrossRef
Position statement of Italian Society of Obesity (SIO): Gestational Obesity
Luigi Barrea, Stefania Camastra, Silvia Garelli, Valeria Guglielmi, Melania Manco, Fernanda Velluzzi, Rocco Barazzoni, Ludovica Verde, Giovanna Muscogiuri
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2024;[Epub] CrossRef
The Role of Xanthine Oxidase in Pregnancy Complications: A Systematic Review
Lorenzo Annesi, Giovanni Tossetta, Claudio Borghi, Federica Piani
Antioxidants.2024; 13(10): 1234. CrossRef
Non-Pharmacological Management of Gestational Diabetes Mellitus with a High Fasting Glycemic Parameter: A Hospital-Based Study in Vietnam
Hang Giang Nguyen, Khanh Trang Huynh Nguyen, Phuc Nhon Nguyen
Journal of Clinical Medicine.2024; 13(19): 5895. CrossRef
Role of health literacy on lifestyle and glycemic control among women with diabetes during pregnancy: a cross-sectional study
Towhid Babazadeh, Sara Pourrazavi, Zahra Ardeshiri, Akbar Nadi, Khalil Maleki Chollou
Frontiers in Public Health.2024;[Epub] CrossRef
Bioinformatics-based Identification of Ferroptosis-related Genes and their Diagnostic Value in Gestational Diabetes Mellitus
Xiaomei Lv, Yujun An
Endocrine, Metabolic & Immune Disorders - Drug Targets.2024; 24(14): 1611. CrossRef
Behenic acid alleviates inflammation and insulin resistance in gestational diabetes mellitus by regulating TLR4/NF-κB signaling pathway
Kerong Liu, Ying Gu, Xingnan Pan, Sha Chen, Jie Cheng, Le Zhang, Minkai Cao
iScience.2024; 27(10): 111019. CrossRef
Quantitative Analysis of Myocardial Work in Gestational Diabetes Mellitus Using Noninvasive Left Ventricular Pressure‐Strain Loop Measurement
Jiaqi Zhang, Caihong Chang, Changxiu Yu, Yao Peng, Wei Feng, Juan Song, Ji Wu
Echocardiography.2024;[Epub] CrossRef
Beyond one size fits all: Probing patient choices in gestational diabetes management, from screening to postpartum
Ayman Mobin, Amir Obeid, Imad El‐Kebbi, Dean Everett, Saleh Ibrahim, Joviana Farhat, Basem Al‐Omari
Chronic Diseases and Translational Medicine.2024;[Epub] CrossRef
Association of joint exposure to organophosphorus flame retardants and phthalate acid esters with gestational diabetes mellitus: a nested case-control study
Qi Lang, Xianfeng Qin, Xiangyuan Yu, Shudan Wei, Jinyan Wei, Min Zhang, Chaochao Zhao, Jun Zhang, Dingyuan Zeng, Xiaoying Zhang, Bo Huang
BMC Pregnancy and Childbirth.2024;[Epub] CrossRef
Amelioration of Insulin Resistance after Delivery Is Associated with Reduced Risk of Postpartum Diabetes in Women with Gestational Diabetes Mellitus
Heejun Son, Joon Ho Moon, Sung Hee Choi, Nam H. Cho, Soo Heon Kwak, Hak Chul Jang
Endocrinology and Metabolism.2024; 39(5): 701. CrossRef
Are Maternal Dietary Patterns During Pregnancy Associated with the Risk of Gestational Diabetes Mellitus? A Systematic Review of Observational Studies
Charikleia Kyrkou, Apostolos P. Athanasiadis, Michael Chourdakis, Stefania Kada, Costas G. Biliaderis, Georgios Menexes, Alexandra-Maria Michaelidou
Nutrients.2024; 16(21): 3632. CrossRef
Gestational diabetes mellitus – Can we do better with postpartum diabetes screening?
Hadas Zafrir-Danieli, Ohad Houri, Reut Rotem, Dror Weinberg-Almog, Or Bercovich, Eran Hadar, Alexandra Berezowsky
European Journal of Obstetrics & Gynecology and Reproductive Biology.2024; 303: 153. CrossRef
Dietary inflammatory index as a predictor of prediabetes in women with previous gestational diabetes mellitus
Yanhong Xu, Zhiying Yao, Jiayi Lin, Nan Wei, Ling Yao
Diabetology & Metabolic Syndrome.2024;[Epub] CrossRef
Influence of Nutrition on Growth and Development of Metabolic Syndrome in Children
Alessia Quarta, Maria Teresa Quarta, Concetta Mastromauro, Francesco Chiarelli, Cosimo Giannini
Nutrients.2024; 16(22): 3801. CrossRef
Usefulness of Glycated Albumin Levels in Predicting the Maternal or Neonatal Complications of Gestational Diabetes Mellitus during Late Pregnancy in South Korea: A Retrospective Study
Jihan Kim, Sami Lee, Jong Sung Kim
Korean Journal of Family Medicine.2024;[Epub] CrossRef
Combination of body mass index and body fat percentage in middle and late pregnancy to predict pregnancy outcomes in patients with gestational diabetes in Wenzhou, China: a single-centre retrospective cohort study
Bingru Chen, Lanxi Chen, Xiner Zhao, Tao You, Zhi Zheng, Yilin Chen, Shuoru Zhu
BMJ Open.2024; 14(11): e086703. CrossRef
The Predictive Power of the Mother’s Neck Circumference in the Early Diagnosis of Gestational Diabetes Mellitus
Mahin Balouchi Mahani, Mahtab Sattari, Akbar Mehralizade, Azam Amirian
Journal of Nursing and Midwifery Sciences.2024;[Epub] CrossRef
Insights into the pathogenesis of gestational and hepatic diseases: the impact of ferroptosis
Yilan You, Zhiwen Qian, Ying Jiang, Lingyan Chen, Danping Wu, Lu Liu, Feng Zhang, Xin Ning, Yan Zhang, Jianping Xiao
Frontiers in Cell and Developmental Biology.2024;[Epub] CrossRef
The effect of diabetes education on maternal and neonatal outcomes in pregnant women diagnosed with gestational diabetes
Serap Topkara, Çağanay Soysal
BMC Pregnancy and Childbirth.2024;[Epub] CrossRef
Administration of a diabetes-specific formula can improve postprandial glycemic control and delay insulin use in gestational diabetes mellitus: A randomized controlled trial from two centers
Ruihua Yang, Weiling Han, Wei Zheng, Dong Xu, Jing He, Xianxian Yuan, Li Zhang, Zhihong Tian, Guanghui Li
Clinical Nutrition.2024; 43(12): 265. CrossRef
Circ‐ADAM9 Knockdown Reduces Insulin Resistance and Placental Injury in Diabetic Mice via MAPK Pathway Inactivation
Ai Zhao, Yawen Yang, Yijun Yang, Zhenjing Chi, Yanlan Sun
American Journal of Reproductive Immunology.2024;[Epub] CrossRef
The Efficacy and Acceptability of Flash Glucose Monitoring in Pregnant Women with Gestational Diabetes Mellitus: A Systematic Review
Franciszek Ługowski, Julia Babińska, Zofia Awiżeń-Panufnik, Ewelina Litwińska-Korcz, Magdalena Litwińska, Artur Ludwin, Paweł Jan Stanirowski
Journal of Clinical Medicine.2024; 13(23): 7129. CrossRef
Impact of Gestational Diabetes Mellitus on Fetal Growth and Nutritional Status in Newborns
Karolina Karcz, Barbara Królak-Olejnik
Nutrients.2024; 16(23): 4093. CrossRef
Association of overweight and obesity with gestational diabetes mellitus among pregnant women attending antenatal care clinics in Addis Ababa, Ethiopia: a case-control study
Yeabsra Mesfin Seifu, Negussie Deyessa, Yimer Seid Yimer
BMJ Open.2024; 14(11): e082539. CrossRef
Gestational diabetes mellitus and risk of neonatal respiratory distress syndrome: a systematic review and meta-analysis
Fang Yang, Hua Liu, Cuixia Ding
Diabetology & Metabolic Syndrome.2024;[Epub] CrossRef
Associations of systemic immune-inflammation index and systemic inflammation response index with maternal gestational diabetes mellitus: Evidence from a prospective birth cohort study
Shuanghua Xie, Enjie Zhang, Shen Gao, Shaofei Su, Jianhui Liu, Yue Zhang, Yingyi Luan, Kaikun Huang, Minhui Hu, Xueran Wang, Hao Xing, Ruixia Liu, Wentao Yue, Chenghong Yin
Chinese Medical Journal.2024;[Epub] CrossRef
Gestational Diabetes, the Human Milk Metabolome, and Infant Growth and Adiposity
Emily M. Nagel, Armando Peña, Jonathan M. Dreyfuss, Eric F. Lock, Kelsey E. Johnson, Chang Lu, David A. Fields, Ellen W. Demerath, Elvira Isganaitis
JAMA Network Open.2024; 7(12): e2450467. CrossRef
Prediction of Possible Adverse Effects of Gestational Diabetes Mellitus on Maternal and Fetal Glomeruli by Urine and Amniotic Fluid Podocyte Degradation Products
Fatma Tanilir Cagiran, Nihal Mavral, Zercan Kali, Pinar Kirici
Diagnostics.2024; 14(24): 2771. CrossRef
LncRNAs Involved in Antioxidant Response Regulation as Biomarkers of Gestational Diabetes: A Study on H19, MALAT1 and MEG3
Jovana Stevanović, Uroš Petrović, Ana Penezić, Ognjen Radojičić, Daniela Ardalić, Milica Mandić, Vesna Mandić-Marković, Željko Miković, Miloš Brkušanin, Olgica Nedić, Zorana Dobrijević
Antioxidants.2024; 13(12): 1503. CrossRef
Decreased telomerase activity and shortened telomere length in infants whose mothers have gestational diabetes mellitus and increased severity of telomere shortening in male infants
Shuhua Liu, Liping Xu, Yan Cheng, Dehong Liu, Bin Zhang, Xianxia Chen, Mingming Zheng
Frontiers in Endocrinology.2024;[Epub] CrossRef
Infants of Diabetic Mothers and Associated Complications in the Neonatal Intensive Care Unit
Hussain A Al Ghadeer, Ahad A Mohamed , Mariam A Alali, Kulthum A Al Mahdi, Sajeda M Almishal, Tawfiq M Aljubran, Abdulelah A Alneamah , Roaa S Alduhmush , Mohammed J Alobaid , Tarfh S Alsaad , Hayam S Almoagal, Abdullah M Albuali , Mudhawi F Alsu
Cureus.2024;[Epub] CrossRef
U-shaped Association Between Folic Acid Supplementation and the Risk of Gestational Diabetes Mellitus in Chinese Women
Jiuming Zou, Qiang Fu, Xiaoliu Huang, Zhao Yao, Weiye Wang
Canadian Journal of Diabetes.2023; 47(1): 78. CrossRef
Vitamin D Supplementation for the Outcomes of Patients with Gestational Diabetes Mellitus and Neonates: A Meta-Analysis and Systematic Review
Chunfeng Wu, Yang Song, Xueying Wang, Pier P. Sainaghi
International Journal of Clinical Practice.2023; 2023: 1. CrossRef
Lipolysis and gestational diabetes mellitus onset: a case-cohort genome-wide association study in Chinese
Miao Zhang, Qing Li, Kai-Lin Wang, Yao Dong, Yu-Tong Mu, Yan-Min Cao, Jin Liu, Zi-Heng Li, Hui-Lu Cui, Hai-Yan Liu, An-Qun Hu, Ying-Jie Zheng
Journal of Translational Medicine.2023;[Epub] CrossRef
Interactive effect of prepregnancy overweight/obesity and GDM history on prevalence of GDM in biparous women
Xia Xu, Feipeng Huang, Yanni Guo, Lianghui Zheng, Jianying Yan
Frontiers in Endocrinology.2023;[Epub] CrossRef
Microbiome Changes in Pregnancy Disorders
Luca Giannella, Camilla Grelloni, Dayana Quintili, Alessia Fiorelli, Ramona Montironi, Sonila Alia, Giovanni Delli Carpini, Jacopo Di Giuseppe, Arianna Vignini, Andrea Ciavattini
Antioxidants.2023; 12(2): 463. CrossRef
Effects of early standardized management on the growth trajectory of offspring with gestational diabetes mellitus at 0–5 years old: a preliminary longitudinal study
Bingbing Guo, Jingjing Pei, Yin Xu, Yajie Wang, Xinye Jiang
Scientific Reports.2023;[Epub] CrossRef
Prediction model for gestational diabetes mellitus using the XG Boost machine learning algorithm
Xiaoqi Hu, Xiaolin Hu, Ya Yu, Jia Wang
Frontiers in Endocrinology.2023;[Epub] CrossRef
Prevalence and outcomes of gestational diabetes mellitus in Indian women: Insights from a large real-world study over ten years at tertiary care research institute
Sanjay Gupte, Gayatri Venkataraman, Aarti S. Shah, Shalaka Jamenis, Chandrakant Rao, Shweta M. Jangam, Kaveri M. Adki, Onkar C. Swami
International Journal of Diabetes in Developing Countries.2023; 43(4): 511. CrossRef
Gestational diabetes mellitus: state of art
S. A. Pletneva, E. V. Enkova, O. V. Khoperskaya, S. V. Shamarin, V. V. Enkova
Meditsinskiy sovet = Medical Council.2023; (5): 136. CrossRef
Effect of folic acid supplementation in the association between short sleep duration and gestational diabetes mellitus
Zhen Yang, Sisi Hu, Wei Tong, Zhihao Xu, Xiaoliu Huang, Weiye Wang
Sleep and Breathing.2023; 27(6): 2509. CrossRef
Birth weight and large for gestational age trends in offspring of pregnant women with gestational diabetes mellitus in southern China, 2012-2021
Li-Rong He, Li Yu, Yong Guo
Frontiers in Endocrinology.2023;[Epub] CrossRef
Root causes of long-term complications of gestational diabetes mellitus: Metabolic disturbances of the host and gut microbiota
Mingjin Tao, Gaochen Lu, Sheng Zhang, Pan Li
Clinica Chimica Acta.2023; 548: 117490. CrossRef
Analysis on Related Risk Factors for Gestational Diabetes Mellitus (GDM) in Subsequent Pregnancies in Multiparous Women with No History of GDM
文静张
Advances in Clinical Medicine.2023; 13(07): 11628. CrossRef
Fetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: A potential threat for programming cardiovascular disease
Mariana S. Diniz, Ursula Hiden, Inês Falcão-Pires, Paulo J. Oliveira, Luis Sobrevia, Susana P. Pereira
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(8): 166834. CrossRef
Diagnosis and management of gestational diabetes mellitus
Tae Jung Oh
Journal of the Korean Medical Association.2023; 66(7): 414. CrossRef
Hypoglycemia in Children: Major Endocrine-Metabolic Causes and Novel Therapeutic Perspectives
Alessia Quarta, Daniela Iannucci, Miriana Guarino, Annalisa Blasetti, Francesco Chiarelli
Nutrients.2023; 15(16): 3544. CrossRef
Relation between weight gain during pregnancy and postpartum reclassification in gestational diabetes
Sofia Coelho, Marta Canha, Ana Rita Leite, João Sérgio Neves, Ana Isabel Oliveira, Davide Carvalho, Maria do Céu Ameida
Endocrine.2023; 82(2): 296. CrossRef
Nurturing through Nutrition: Exploring the Role of Antioxidants in Maternal Diet during Pregnancy to Mitigate Developmental Programming of Chronic Diseases
Mariana S. Diniz, Carina C. Magalhães, Carolina Tocantins, Luís F. Grilo, José Teixeira, Susana P. Pereira
Nutrients.2023; 15(21): 4623. CrossRef
Blood manganese level and gestational diabetes mellitus: a systematic review and meta-analysis
Yingmei Sun, Yu Zhang
Journal of Obstetrics and Gynaecology.2023;[Epub] CrossRef
Multiparity increases the risk of diabetes by impairing the proliferative capacity of pancreatic β cells
Joon Ho Moon, Joonyub Lee, Kyun Hoo Kim, Hyun Jung Kim, Hyeongseok Kim, Hye-Na Cha, Jungsun Park, Hyeonkyu Lee, So-young Park, Hak Chul Jang, Hail Kim
Experimental & Molecular Medicine.2023; 55(10): 2269. CrossRef
Physiological Mechanisms Inherent to Diabetes Involved in the Development of Dementia: Alzheimer’s Disease
Himan Mohamed-Mohamed, Victoria García-Morales, Encarnación María Sánchez Lara, Anabel González-Acedo, Teresa Pardo-Moreno, María Isabel Tovar-Gálvez, Lucía Melguizo-Rodríguez, Juan José Ramos-Rodríguez
Neurology International.2023; 15(4): 1253. CrossRef
Synergistic effect between pre-pregnancy smoking and assisted reproductive technology on gestational diabetes mellitus in twin pregnancies
Lingyu Zhang, Yan Huang, Mingjin Zhang, Yanqi Jin
Acta Diabetologica.2023; 61(2): 205. CrossRef
A Comprehensive Review of Gestational Diabetes Mellitus: Impacts on Maternal Health, Fetal Development, Childhood Outcomes, and Long-Term Treatment Strategies
Vaishnavi S Nakshine, Sangita D Jogdand
Cureus.2023;[Epub] CrossRef
The role of dietary fiber on preventing gestational diabetes mellitus in an at-risk group of high triglyceride-glucose index women: a randomized controlled trial
Yannan Cao, Jing Sheng, Dongyao Zhang, Li Chen, Ying Jiang, Decui Cheng, Yao Su, Yuexin Yu, Haoyi Jia, Pengyuan He, Li Wang, Xianming Xu
Endocrine.2023; 82(3): 542. CrossRef
Correlation between PAPP-A serum levels in the first trimester of pregnancy with the occurrence of gestational diabetes, a multicenter cohort study
Sedigheh Borna, Masoumeh Ashrafzadeh, Marjan Ghaemi, Nasim Eshraghi, Nafiseh Hivechi, Sedigheh Hantoushzadeh
BMC Pregnancy and Childbirth.2023;[Epub] CrossRef
Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
Erika Di Zazzo, Sergio Davinelli, Serena Panichella, Giovanni Scapagnini, Mariano Intrieri, Silvio Garofalo
Open Medicine.2023;[Epub] CrossRef
Advancements in Nutritional Strategies for Gestational Diabetes Management: A Systematic Review of Recent Evidence
Juan Carlos Sánchez-García, Ines Saraceno López-Palop, Beatriz Piqueras-Sola, Jonathan Cortés-Martín, Elena Mellado-García, Inmaculada Muñóz Sánchez, Raquel Rodríguez-Blanque
Journal of Clinical Medicine.2023; 13(1): 37. CrossRef
Neuroprotective Potential of Punicalagin, a Natural Component of Pomegranate Polyphenols: A Review
Peng Chen, ZhiLei Guo, Benhong Zhou
Journal of Integrative Neuroscience.2023;[Epub] CrossRef
Comparative efficacy and safety of glyburide, metformin, and insulin in treatment of gestational diabetes mellitus
Jing Lin, Rong-zu Tu, Xun-yu Hong
Medicine.2022;[Epub] CrossRef
Stacking Ensemble Method for Gestational Diabetes Mellitus Prediction in Chinese Pregnant Women: A Prospective Cohort Study
Ruiyi Liu, Yongle Zhan, Xuan Liu, Yifang Zhang, Luting Gui, Yimin Qu, Hairong Nan, Yu Jiang, Mehdi Gheisari
Journal of Healthcare Engineering.2022; 2022: 1. CrossRef
Secular increase in the prevalence of gestational diabetes and its associated adverse pregnancy outcomes from 2014 to 2021 in Hebei province, China
Mei-Ling Tian, Li-Yan Du, Guo-Juan Ma, Ting Zhang, Xu-Yuan Ma, Ying-Kui Zhang, Zeng-Jun Tang
Frontiers in Endocrinology.2022;[Epub] CrossRef
Aquaporin-8 overexpression is involved in vascular structure and function changes in placentas of gestational diabetes mellitus patients
Yanxing Shan, Jiawen Cui, Xinyi Kang, Weichun Tang, Yiling Lu, Ying Gao, Liping Chen
Open Life Sciences.2022; 17(1): 1473. CrossRef
Vitamin D status and levels of pro-inflammatory cytokines in newborns born to mothers with endocrine diseases
N. E. Verisokina, L. Ya. Klimov, I. N. Zakharova, A. L. Zaplatnikov, V. V. Zubkov, A. A. Momotova, V. A. Kuryaninova, R. A. Atanesyan, T. V. Zhelezniakova, M. A. Petrosyan, D. V. Bobryshev, D. A. Volkov, Z. A. Magomadova
Meditsinskiy sovet = Medical Council.2022; (19): 9. CrossRef
IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies
Aleksandra Vilotić, Mirjana Nacka-Aleksić, Andrea Pirković, Žanka Bojić-Trbojević, Dragana Dekanski, Milica Jovanović Krivokuća
International Journal of Molecular Sciences.2022; 23(23): 14574. CrossRef
Higher Muscle Mass Protects Women with Gestational Diabetes Mellitus from Progression to Type 2 Diabetes Mellitus
Yujin Shin, Joon Ho Moon, Tae Jung Oh, Chang Ho Ahn, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang
Diabetes & Metabolism Journal.2022; 46(6): 890. CrossRef
Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus
Yindi Bao, Jun Zhang, Yi Liu, Lianzhi Wu, Jing Yang
Frontiers in Genetics.2022;[Epub] CrossRef
The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders
Mirjana Nacka-Aleksić, Andrea Pirković, Aleksandra Vilotić, Žanka Bojić-Trbojević, Milica Jovanović Krivokuća, Francesca Giampieri, Maurizio Battino, Dragana Dekanski
Nutrients.2022; 14(24): 5246. CrossRef

Pathophysiology
Insulin Resistance: From Mechanisms to Therapeutic Strategies: Shin-Hae Lee, Shi-Young Park, Cheol Soo Choi; Diabetes Metab J. 2022;46(1):15-37. Published online December 30, 2021; DOI: https://doi.org/10.4093/dmj.2021.0280

58,382 View
4,214 Download
340 Web of Science
372 Crossref

Abstract PDF PubReader ePub

Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin. Although the underlying mechanism of insulin resistance is not fully understood, several credible theories have been proposed. In this review, we summarize the functions of insulin in glucose metabolism in typical metabolic tissues and describe the mechanisms proposed to underlie insulin resistance, that is, ectopic lipid accumulation in liver and skeletal muscle, endoplasmic reticulum stress, and inflammation. In addition, we suggest potential therapeutic strategies for addressing insulin resistance.

Citations

Citations to this article as recorded by

Diabetes and its Complications: Role of Luteolin, A Wonder Chemical from the Natural Source
Gandhar Pradhan, Yogesh A. Kulkarni
Current Diabetes Reviews.2025;[Epub] CrossRef
The relation between dietary polysaccharide intake and urinary excretion of tetraglucoside
Candelas Gross‐Valle, Tessa C. Jacobs, Janneke D. A. Dijck‐Brouwer, Janniek Lubberts, Barbara M. Bakker, Stephan J. L. Bakker, Yvonne van der Veen, Andrea B. Schreuder, Terry G. J. Derks, Jennifer van der Krogt, Joost Groen, M. Rebecca Heiner‐Fokkema
Journal of Inherited Metabolic Disease.2025;[Epub] CrossRef
Endothelial versus Metabolic Insulin Resistance, A Descriptive Review
Xiaohui Chen, Huajie Yao, Jiaqi Lai, Yanmei Chen, Xiaodong Li, Shanshan Li, Ling Li, Fazhong He
Current Diabetes Reviews.2025;[Epub] CrossRef
Quantitative assessment of the thickness of the buccal subcutaneous fat using computed tomography to detect diabetes mellitus
Ryoga Atsumi, Kotaro Ito, Naohisa Hirahara, Hirotaka Muraoka, Yuta Kohinata, Takashi Kaneda
Oral Science International.2025;[Epub] CrossRef
BACE1 inhibition via miR-6838-5p overexpression inhibits insulin resistance and the immune response in HFD-induced obesity in mice model
Yubo Han, Zhenhua Quan, Miao Tian, Ruinan Wang, Donghao Guo, Dandan Zhang, Li Liu
Immunopharmacology and Immunotoxicology.2025; 47(1): 42. CrossRef
Chemical characterization and DPP IV inhibitory capacity of purified adzuki bean β-vignin digest in comparison to soybean β-conglycinin and in vitro effect of β-vignin on diabetic-related outcomes
Shu Hang Kwan, Frida Esteves, Emily Davis, Elvira Gonzalez de Mejia
Food Chemistry.2025; 467: 142285. CrossRef
Uric acid in diabetic microvascular complications: Mechanisms and therapy
Xin Li, Bo Huang, Yue Liu, Meng Wang, Jing-Qiu Cui
Journal of Diabetes and its Complications.2025; 39(2): 108929. CrossRef
Value of Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) in Assessing Liver Fibrosis in Metabolic Dysfunction-Associated Liver Disease: A Comprehensive Review of its Serum Biomarker Role
Mohammadjavad Sotoudeheian
Current Protein & Peptide Science.2025; 26(1): 6. CrossRef
Coumarin derivatives against diabetics: a systematic target-specific drug repurposing approach via molecular docking-dynamic simulation
Prachi Rani Sahu, Dhananjay Kumar Tanty, Susanta Kumar Sahu
Journal of Taibah University for Science.2025;[Epub] CrossRef
Multiple pesticide exposure and impaired glucose regulation in U.S. non-diabetic population
Xingdi Zhu, Congxin Chen, Qi Liu, Zhihong Zhu, Xiaoli Wu, Yuqing Zhang
Environmental Pollution.2025; 366: 125519. CrossRef
The predictive value of estimated glucose disposal rate for all-cause and cardiovascular mortality in the US non-diabetic population aged ≥60 years: A population-based cohort study
Botao Zhu, Chenghui Cao, Wenwu Liu, Yuxuan Liu, Yonghong Luo, Daoquan Peng
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2025; 19(1): 103182. CrossRef
Deciphering endocrine function of adipose tissue and its significant influences in obesity-related diseases caused by its dysfunction
Feiyi Duan, Jiaoyan Wu, Jiayi Chang, Haoyuan Peng, Zitao Liu, Pengfei Liu, Xu Han, Tiantian Sun, Dandan Shang, Yutian Yang, Zhihao Li, Pengkun Li, Yixuan Liu, Yonghao Zhu, Yunzhi Lv, Xiumei Guo, Ying Zhao, Yang An
Differentiation.2025; 141: 100832. CrossRef
Sirtuin, irisin, and vitamin D as predictors of diabetes mellitus with uncontrolled glycemia in Indonesian patients
Elly Herwana, Yenny, Alvina, Kurniasari, Clarissa Asha Febinia, Pusparini
Endocrine and Metabolic Science.2025; 17: 100214. CrossRef
Ursodeoxycholic acid grafted chitosan oligosaccharide self-assembled micelles with enhanced oral absorption and antidiabetic effect of oleanolic acid
Minghao Yuan, Yan Wan, Yulu Wang, Sihui Li, Jiamei Tang, Xue Liang, Xin Tan, Sirui Yi, Xiaohang Wei, Xiaohong Li, Li Guo, Yiping Guo
Food Chemistry.2025; 470: 142708. CrossRef
Associations Between Diabetes Mellitus and Neurodegenerative Diseases
Leszek Szablewski
International Journal of Molecular Sciences.2025; 26(2): 542. CrossRef
Structure characterization of Grifola frondosa polysaccharide and its effect on insulin resistance in HFD-fed mice
Yin-Yi Ding, Jinchi Lan, Yuxin Wang, Yuxiang Pan, Tianyuan Song, Shizhu Liu, Zhenyu Gu, Yujun Ge
npj Science of Food.2025;[Epub] CrossRef
Effect of Total and Partial Meal Replacements on Factors Related to Glucose Metabolism: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Niloofar Sadat Maddahi, Mohammad Hassan Sohouli, Elma Izze da Silva Magalhães, Neda Ezoddin, Azadeh Nadjarzadeh
Nutrition Reviews.2025;[Epub] CrossRef
Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome—An Update
Imadeldin Elfaki, Rashid Mir, Mohamed E. Elnageeb, Abdullah Hamadi, Zeyad M. Alharbi, Ruqaiah I. Bedaiwi, Jamsheed Javid, Tariq Alrasheed, Dalal Alatawi, Basmah M. Alrohaf, Mohammed K. Abunab, Turki Ahmed Muqri
Medicina.2025; 61(1): 83. CrossRef
Apitherapy for diabetes mellitus: mechanisms and clinical implications
Andrés Jagua-Gualdrón, Nicolai Andrés García-Reyes, Roger Edwin Fernández-Bernal
Journal of Complementary and Integrative Medicine.2025;[Epub] CrossRef
Exploration of the Fasting Hypoglycemic Mechanism of Casein Hydrolysate Enriched with Glu/Gln and Glu/Gln-Containing Peptides in db/db Diabetic-like Mice Using Multiomics Analysis
Chenyang Wang, Rong Xu, Chibuike C. Udenigwe, Lianzhu Lin, Lin Zheng, Mouming Zhao
Journal of Agricultural and Food Chemistry.2025;[Epub] CrossRef
Insulin signaling and oxidative stress: Bridging the gap between type 2 diabetes mellitus and Alzheimer's disease
Fengqing Xu, Jingshan Shi
Journal of Alzheimer’s Disease.2025;[Epub] CrossRef
Diabetic Encephalopathy: Role of Oxidative and Nitrosative Factors in Type 2 Diabetes
Debashree Mazumdar, Santosh Singh
Indian Journal of Clinical Biochemistry.2024; 39(1): 3. CrossRef
Underlying mechanisms and molecular targets of genistein in the management of type 2 diabetes mellitus and related complications
Tao Jiang, Yuhe Dong, Wanying Zhu, Tong Wu, Linyan Chen, Yuantong Cao, Xi Yu, Ye Peng, Ling Wang, Ying Xiao, Tian Zhong
Critical Reviews in Food Science and Nutrition.2024; 64(31): 11543. CrossRef
Validation of a physiological type 2 diabetes model in human periodontal ligament stem cells
Dongqing Ai, Yuanyuan Yin, Xuyun Xia, Sihan Yang, Yu Sun, Jie Zhou, Han Qin, Xiaohui Xu, Jinlin Song
Oral Diseases.2024; 30(5): 3363. CrossRef
Materials and structure of polysaccharide-based delivery carriers for oral insulin: A review
Xinran Wang, Hongnan Sun, Taihua Mu
Carbohydrate Polymers.2024; 323: 121364. CrossRef
β-Thalassemia and Diabetes Mellitus: Current State and Future Directions
Jalal Taneera, Eglal Mahgoub, Reem Qannita, Ayah Alalami, Ola Al Shehadat, Mona Youssef, Ayah Dib, Alaa Al Hajji, Amani Al Hajji, Fatheya Al-Khaja, Hany Dewedar, Mawieh Hamad
Hormone and Metabolic Research.2024; 56(04): 272. CrossRef
Mulberry leaf multi-components exert hypoglycemic effects through regulation of the PI-3K/Akt insulin signaling pathway in type 2 diabetic rats
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Journal of Ethnopharmacology.2024; 319: 117307. CrossRef
Thyroid cancer and insulin resistance
Gabriela Brenta, Fernando Di Fermo
Reviews in Endocrine and Metabolic Disorders.2024; 25(1): 19. CrossRef
Comparative profiling of gut microbiota and metabolome in diet-induced obese and insulin-resistant C57BL/6J mice
Hobby Aggarwal, Jyoti Gautam, Deepika Kumari, Sonu Kumar Gupta, Sneh Bajpai, Kartikey Chaturvedi, Yashwant Kumar, Madhu Dikshit
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2024; 1871(2): 119643. CrossRef
CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation
Patricia O. Benedet, Nooshin S. Safikhan, Maria J. Pereira, Bryan M. Lum, José Diego Botezelli, Cheng-Hsiang Kuo, Hua-Lin Wu, Barbara P. Craddock, W. Todd Miller, Jan W. Eriksson, Jessica T.Y. Yue, Edward M. Conway
eBioMedicine.2024; 99: 104906. CrossRef
The Antiobesity Effects and Potential Mechanisms of Theaflavins
Yi Fang, Jun Wang, Yu Cao, Wenrui Liu, Lianxiang Duan, Jing Hu, Jinghua Peng
Journal of Medicinal Food.2024; 27(1): 1. CrossRef
The role of zinc finger proteins in the fate determination of mesenchymal stem cells during osteogenic and adipogenic differentiation
Bolun Li, Shibo Liu, Ze He, En Luo, Hanghang Liu
The International Journal of Biochemistry & Cell Biology.2024; 167: 106507. CrossRef
Gentianella turkestanorum (Gand.) Holub, a Chinese Herbal Medicine that can Alleviate T2DM in Db/db Mice, and its Active Mechanism of Action
Ying Wei, Jiaxin Sun, Liya Su, Tunhai Xu
Pharmacognosy Magazine.2024; 20(2): 646. CrossRef
Hyperglycemia affects axial signs in patients with Parkinson’s disease through mechanisms of insulin resistance or non-insulin resistance
Ruidan Wang, Zhaohui Jin, Qiaoxia Zhen, Lin Qi, Cui Liu, Ping Wang, Yonghong Liu, Jinping Fang, Yanjun Liu, Yuan Su, Yixuan Wang, Detao Meng, Hongjiao Yan, Yi Zhen, Zhenzhen Li, Boyan Fang
Neurological Sciences.2024; 45(5): 2011. CrossRef
Insulin resistance: Risk factors, diagnostic approaches and mathematical models for clinical practice, epidemiological studies, and beyond
Janusz Krzymien, Piotr Ladyzynski
Biocybernetics and Biomedical Engineering.2024; 44(1): 55. CrossRef
Effects of silybin supplementation on growth performance, serum indexes and liver transcriptome of Peking ducks
Ziyue Zhang, Bozhi Shi, Xueze Lv, Yingchao Dong, Lei Li, Zhaofei Xia
Frontiers in Veterinary Science.2024;[Epub] CrossRef
Effects of Consuming Beverages Sweetened with Fructose, Glucose, High-Fructose Corn Syrup, Sucrose, or Aspartame on OGTT-Derived Indices of Insulin Sensitivity in Young Adults
Bettina Hieronimus, Valentina Medici, Vivien Lee, Marinelle V. Nunez, Desiree M. Sigala, Andrew A. Bremer, Chad L. Cox, Nancy L. Keim, Jean-Marc Schwarz, Giovanni Pacini, Andrea Tura, Peter J. Havel, Kimber L. Stanhope
Nutrients.2024; 16(1): 151. CrossRef
Association Between Insulin Resistance Markers and Poor Prognosis in Patients With Acute Ischemic Stroke After Intravenous Thrombolysis
Haimei Liu, Denglu Liu, Peng Zuo
The Neurologist.2024; 29(4): 218. CrossRef
Interplay of Angiotensin Peptides, Vasopressin, and Insulin in the Heart: Experimental and Clinical Evidence of Altered Interactions in Obesity and Diabetes Mellitus
Ewa Szczepanska-Sadowska
International Journal of Molecular Sciences.2024; 25(2): 1310. CrossRef
High-Density Lipoprotein Is Located Alongside Insulin in the Islets of Langerhans of Normal and Rodent Models of Diabetes
Sahar Mohsin, Haba Elabadlah, Mariam K. Alotaiba, Suhail AlAmry, Shamma J. Almehairbi, Maha M. K. Harara, Aisha M. H. Almuhsin, Saeed Tariq, Frank Christopher Howarth, Ernest A. Adeghate
Nutrients.2024; 16(2): 313. CrossRef
Sweet triterpenoid glycoside from Cyclocarya paliurus ameliorates obesity-induced insulin resistance through inhibiting the TLR4/NF-κB/NLRP3 inflammatory pathway
Jie Li, Junyu He, Haibo He, Xiao Wang, Shuran Zhang, Yumin He, Jihong Zhang, Chengfu Yuan, HongWu Wang, Daoxiang Xu, Chaowang Pan, Huifan Yu, Kun Zou
Current Research in Food Science.2024; 8: 100677. CrossRef
Effect of supplementation with probiotics or synbiotics on cardiovascular risk factors in patients with metabolic syndrome: a systematic review and meta-analysis of randomized clinical trials
TingRui Chen, Jing Wang, ZeKun Liu, Fei Gao
Frontiers in Endocrinology.2024;[Epub] CrossRef
Diabetes mellitus progression in β-thalassaemia major patients: The impact of iron overload
Eglal Omer Mahgoub, Reem Qannita, Ayah Alalami, Ola Al Shehadat, Rabah Al Mahmoud, Ayah Dib, Alaa Al Hajji, Amani Al Hajji, Fatheya Al Khaja, Hany Dewedar, Mawieh Hamad, Jalal Taneera
Advances in Biomedical and Health Sciences.2024; 3(1): 5. CrossRef
Dietary Tomato Pectin Attenuates Hepatic Insulin Resistance and Inflammation in High-Fat-Diet Mice by Regulating the PI3K/AKT Pathway
Jing Sun, Kongyan Wu, Pan Wang, Yubin Wang, Dan Wang, Wenting Zhao, Yuanyuan Zhao, Chunhong Zhang, Xiaoyan Zhao
Foods.2024; 13(3): 444. CrossRef
Atractylodes macrocephala Koidz. and Cuscuta chinensis Lam. extract relieves insulin resistance via PI3K/Akt signalling in diabetic Drosophila
Yinghong Li, Ye Xu, Biwei Zhang, Zhigang Wang, Leilei Ma, Longyu Sun, Xiuping Wang, Yimin Lin, Ji-an Li, Chenxi Wu
Journal of Traditional and Complementary Medicine.2024; 14(4): 424. CrossRef
Ketogenic diet ameliorates high-fat diet-induced insulin resistance in mouse skeletal muscle by alleviating endoplasmic reticulum stress
Qin Ma, Lincheng Jiang, Yuehua You, Hongbing Ni, Li Ma, Xiaojing Lin, Zhuyun Wang, Weiyan Yan, Xiaoqiu Xiao, Xinyu Li, Jibin Li
Biochemical and Biophysical Research Communications.2024; 702: 149559. CrossRef
Brain insulin resistance and Alzheimer’s disease: a systematic review
Luis Jesuino de Oliveira Andrade, Luís Matos de Oliveira, Alcina Maria Vinhaes Bittencourt, Letícia Góes de Carvalho Lourenço, Gabriela Correia Matos de Oliveira
Dementia & Neuropsychologia.2024;[Epub] CrossRef
Poorly controlled glycemia and worse beta cell function associate with higher resting and total energy expenditure in adults with obesity and type 2 diabetes: A doubly labeled water study
Kate Lillegard, John A. Del Castillo, Heidi J. Silver
Clinical Nutrition.2024; 43(3): 729. CrossRef
Gut microbiota in insulin resistance: a bibliometric analysis
Weiwei Tian, Li Liu, Ruirui Wang, Yunyun Quan, Bihua Tang, Dongmei Yu, Lei Zhang, Hua Hua, Junning Zhao
Journal of Diabetes & Metabolic Disorders.2024; 23(1): 173. CrossRef
Association of the triglyceride glucose index with all-cause and cardiovascular mortality in a general population of Iranian adults
Ghazaal Alavi Tabatabaei, Noushin Mohammadifard, Hamed Rafiee, Fatemeh Nouri, Asieh Maghami mehr, Jamshid Najafian, Masoumeh Sadeghi, Maryam Boshtam, Hamidreza Roohafza, Fahimeh Haghighatdoost, Marzieh Taheri, Nizal Sarrafzadegan
Cardiovascular Diabetology.2024;[Epub] CrossRef
Changes in Cells Associated with Insulin Resistance
Leszek Szablewski
International Journal of Molecular Sciences.2024; 25(4): 2397. CrossRef
Assessment of insulin resistance using the HOMA index: a comparative approach between premenopausal and postmenopausal women
Ericka Jazmín Tubón Luisa, Carlos Fernando Yauli Flores
Salud, Ciencia y Tecnología.2024; 4: 729. CrossRef
Insulin Resistance: The Increased Risk of Cancers
Leszek Szablewski
Current Oncology.2024; 31(2): 998. CrossRef
Muscle strength and non-alcoholic fatty liver disease/metabolic-associated fatty liver disease
Xuan-Yu Hao, Kai Zhang, Xing-Yong Huang, Fei Yang, Si-Yu Sun
World Journal of Gastroenterology.2024; 30(7): 636. CrossRef
Outcomes With Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes by Baseline Insulin Resistance
Thomas Ebert, Stefan D. Anker, Luis M. Ruilope, Paola Fioretto, Vivian Fonseca, Guillermo E. Umpierrez, Andreas L. Birkenfeld, Robert Lawatscheck, Charlie Scott, Katja Rohwedder, Peter Rossing
Diabetes Care.2024; 47(3): 362. CrossRef
Influence of Obesity and Insulin Resistance on the Reproductive Outcome of Iraqi Women Undergoing Intracytoplasmic Sperm Injection
Sundus Ali Dawood, Hayder Ali Lafta Mossa, Mufeeda Ali Jwad
Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ).2024; 6(1): 179. CrossRef
Metabolic memory: mechanisms and diseases
Hao Dong, Yuezhang Sun, Lulingxiao Nie, Aimin Cui, Pengfei Zhao, Wai Keung Leung, Qi Wang
Signal Transduction and Targeted Therapy.2024;[Epub] CrossRef
Effect of preoperative oral carbohydrates on insulin resistance in patients undergoing laparoscopic cholecystectomy: a randomized controlled trial
Xiaohan Wang, Jingwen Zhuang, Jianxin Cheng, Zeyang Wang, Jingyi Sheng, Shanshan Guo, Rui Wang, Zhiping Wang
Langenbeck's Archives of Surgery.2024;[Epub] CrossRef
Beta‐Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5
Lu Ding, Yang Sun, Yan Liang, Jie Zhang, Zhendong Fu, Caiyue Ren, Pengfei Li, Wen Liu, Rong Xiao, Hao Wang, Zhaoying Zhang, Xuetian Yue, Chunyang Li, Zhuanchang Wu, Yuemin Feng, Xiaohong Liang, Chunhong Ma, Lifen Gao
Advanced Science.2024;[Epub] CrossRef
Metabolic syndrome awareness in the general Korean population: results from a nationwide survey
Hyun-Jin Kim, Mi-Seung Shin, Kyung-Hee Kim, Mi-Hyang Jung, Dong-Hyuk Cho, Ju-Hee Lee, Kwang Kon Koh
The Korean Journal of Internal Medicine.2024; 39(2): 272. CrossRef
Pregnane X receptor knockout mitigates weight gain and hepatic metabolic dysregulation in female C57BL/6 J mice on a long-term high-fat diet
Lidya H. Gebreyesus, Sora Choi, Prince Neequaye, Mattia Mahmoud, Mia Mahmoud, Malvin Ofosu-Boateng, Elizabeth Twum, Daniel O. Nnamani, Lijin Wang, Nour Yadak, Sujoy Ghosh, Frank J. Gonzalez, Maxwell A. Gyamfi
Biomedicine & Pharmacotherapy.2024; 173: 116341. CrossRef
TyG-GGT is a Reliable Non-Invasive Predictor of Advanced Liver Fibrosis in Overweight or Obese Individuals
Lei Jin, Jing Gu, Zhe Zhang, Cheng-Fei Du, Fei-Qi Xu, Xiao-Kun Huang, Zhen-Yu Gao, Ying Li, Li-Li Yu, Xin Zhang, Guo-Qing Ru, Jun-Wei Liu, Lei Liang, Xiao-Dong Sun, Zun-Qiang Xiao
Obesity Surgery.2024; 34(4): 1333. CrossRef
Excess homocysteine inhibits pancreatic β-cell secretory function by repressing Zbtb20 expression
Tianqi Ding, Bo Wen, Jian Chen, Wenbin Chu, Rong Fan, Xuewei Chen
Molecular and Cellular Endocrinology.2024; 586: 112195. CrossRef
Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase
Yuliya Tishova, Svetlana Kalinchenko, George Mskhalaya, Geoffrey Hackett, Mark Livingston, Carola König, Richard Strange, Michael Zitzmann, Amar Mann, Amro Maarouf, Sudarshan Ramachandran
Diabetes, Obesity and Metabolism.2024; 26(6): 2147. CrossRef
Preoperative contributing factors and the remission of diabetes after metabolic surgery: the mediating role of preoperative triglyceride
Lijuan Niu, Liqian Mu, Runda Wu, Shan Tong, Zhongqi Mao, Yi Yang, Jun Yin
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2024;[Epub] CrossRef
Mechanisms of Action of Potentilla discolor Bunge in Type 2 Diabetes Mellitus Based on Network Pharmacology and Experimental Verification in Drosophila
Yinghong Li, Fanwu Wu, Jianbo Zhang, Ye Xu, Hong Chang, Yueyue Yu, Chunhua Jiang, Xiujuan Gao, Huijuan Liu, Zhen Chen, Chenxi Wu, Ji-An Li
Drug Design, Development and Therapy.2024; Volume 18: 747. CrossRef
Diabetes and diabetic associative diseases: An overview of epigenetic regulations of TUG1
Mohammed Ageeli Hakami
Saudi Journal of Biological Sciences.2024; 31(5): 103976. CrossRef
Sleep quality of patients with diabetes mellitus: association with anxiety trait and state
Lidiane Bernardes Faria Vilela, Larissa Cristina dos Santos Camargos, Guilherme Rocha Rodrigues, Adelzí Auto Alves Júnior, Renato Canevari Dutra da Silva, Elton Brás Camargo Júnior
Revista Gaúcha de Enfermagem.2024;[Epub] CrossRef
Qualidade do sono de pacientes com diabetes mellitus: associação com ansiedade traço e estado
Lidiane Bernardes Faria Vilela, Larissa Cristina dos Santos Camargos, Guilherme Rocha Rodrigues, Adelzí Auto Alves Júnior, Renato Canevari Dutra da Silva, Elton Brás Camargo Júnior
Revista Gaúcha de Enfermagem.2024;[Epub] CrossRef
Association of the triglyceride-glucose index with severity of coronary stenosis and in-hospital mortality in patients with acute ST elevation myocardial infarction after percutaneous coronary intervention: a multicentre retrospective analysis cohort stud
Xin Lu, Xin Lin, Yingying Cai, Xiaoxiao Zhang, Haoyu Meng, Weiwei Chen, Peng Yu, Xiaohu Chen
BMJ Open.2024; 14(3): e081727. CrossRef
Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells
Vishal Chavda, Dhananjay Yadav, Snehal Patel, Minseok Song
Brain Sciences.2024; 14(3): 284. CrossRef
Mechanisms of body fat distribution and gluteal-femoral fat protection against metabolic disorders
Maha Alser, Khaled Naja, Mohamed A. Elrayess
Frontiers in Nutrition.2024;[Epub] CrossRef
Regulation of lipid metabolism by E3 ubiquitin ligases in lipid-associated metabolic diseases
Yuanming Zou, Ying Zhang, Mohan Li, Kexin Cao, Chunyu Song, Zhaobo Zhang, Kexin Cai, Danxi Geng, Shuxian Chen, Yanjiao Wu, Naijin Zhang, Guozhe Sun, Jing Wang, Yixiao Zhang, Yingxian Sun
International Journal of Biological Macromolecules.2024; 265: 130961. CrossRef
METS-IR and all-cause mortality in Korean over 60 years old: Korean genome and epidemiology study-health examinees (KoGES-HEXA) cohorts
Ha Eun Ryu, Dong Hyuk Jung, Seok-Jae Heo, Byoungjin Park, Yong Jae Lee
Frontiers in Endocrinology.2024;[Epub] CrossRef
Effects of vitamin family members on insulin resistance and diabetes complications
Hong-Jin Chen, Min Wang, Ding-Min Zou, Gui-You Liang, Si-Yuan Yang
World Journal of Diabetes.2024; 15(3): 568. CrossRef
Alleviative effects of the parthenolide derivative ACT001 on insulin resistance induced by sodium propionate combined with a high-fat diet and its potential mechanisms
Qian Yu, Xiang Zuo, Huijuan Bai, Shuhui Zhang, Jialu Luan, Qili Zhao, Xin Zhao, Xizeng Feng
European Journal of Pharmacology.2024; 971: 176529. CrossRef
The genetic causal relationship between type 2 diabetes, glycemic traits and venous thromboembolism, deep vein thrombosis, pulmonary embolism: a two-sample Mendelian randomization study
Mingyi Yang, Xianjie Wan, Yani Su, Ke Xu, Pengfei Wen, Binfei Zhang, Lin Liu, Zhi Yang, Peng Xu
Thrombosis Journal.2024;[Epub] CrossRef
Transgenerational inheritance of insulin resistance in offspring of white rice-fed female fruit flies
Kehinde Ahmad Adeshina, Kasimu Ghandi Ibrahim, Murtala Bello Abubakar, Mustapha Umar Imam
Scientific African.2024; 24: e02208. CrossRef
PPARβ/δ as a promising molecular drug target for liver diseases: A focused review
Xin Meng, Lin Wang, Yan-Chao Du, Dong Cheng, Tao Zeng
Clinics and Research in Hepatology and Gastroenterology.2024; 48(6): 102343. CrossRef
EPA and DHA differentially improve insulin resistance by reducing adipose tissue inflammation—targeting GPR120/PPARγ pathway
Xian Yang, Xudong Li, Manjiang Hu, Jie Huang, Siyan Yu, Huanting Zeng, Limei Mao
The Journal of Nutritional Biochemistry.2024; 130: 109648. CrossRef
The impact of diabetes mellitus on the development of psychiatric and neurological disorders
Olivia Kelly, Jillian Sullivan, Natalie Carris, Samantha Geci, Athena Martinez, Varvara Liashenko, James Colvin, Emily Misko, Gary Vanderlaan, He Liu, Prasad S. Dalvi
Brain Disorders.2024; 14: 100135. CrossRef
Oligonucleotide therapies for nonalcoholic steatohepatitis
Sixu Li, Feng Xiong, Songbo Zhang, Jinghua Liu, Guangping Gao, Jun Xie, Yi Wang
Molecular Therapy - Nucleic Acids.2024; 35(2): 102184. CrossRef
The Contribution of Type 2 Diabetes to Parkinson’s Disease Aetiology
Samo Ribarič
International Journal of Molecular Sciences.2024; 25(8): 4358. CrossRef
Dose-response associations of triglyceride to high-density lipoprotein cholesterol ratio and triglyceride–glucose index with arterial stiffness risk
Wenkai Zhang, Weifeng Huo, Huifang Hu, Tianze Li, Lijun Yuan, Jinli Zhang, Yifei Feng, Yuying Wu, Xueru Fu, Yamin Ke, Mengmeng Wang, Longkang Wang, Yaobing Chen, Yajuan Gao, Xi Li, Liang Sun, Jinyuan Pang, Zeqiang Zheng, Fulan Hu, Ming Zhang, Yu Liu, Dong
Lipids in Health and Disease.2024;[Epub] CrossRef
Unraveling PCOS: Exploring its causes and diagnostic challenges
Mohd Altaf Dar, Mudasir Maqbool, Zulfkar Qadrie, Irfat Ara, Afshana Qadir
Open Health.2024;[Epub] CrossRef
Association Between Triglyceride-Glucose Index and Diabetic Retinopathy: A Meta-Analysis
Lanchu Yu, Bingqing Li
Hormone and Metabolic Research.2024; 56(11): 785. CrossRef
Serum Klotho and insulin resistance: Insights from a cross-sectional analysis
Laisha Yan, Xiaoyan Hu, Shanshan Wu, Shunying Zhao
Medicine.2024; 103(17): e37971. CrossRef
Research Progress of Correlation between Triglyceride Glucose Index and Kidney Disease
伊琳黄
Advances in Clinical Medicine.2024; 14(04): 2137. CrossRef
Oxygen-Dependent Aspects of Asprosin Action
V. V. Zinchuk, J. S. O. Al-Jebur
Journal of Evolutionary Biochemistry and Physiology.2024; 60(2): 818. CrossRef
Differential Modulation by Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) of Mesenteric Fat and Macrophages and T Cells in Adipose Tissue of Obese fa/fa Zucker Rats
Lena Hong, Peter Zahradka, Carla G. Taylor
Nutrients.2024; 16(9): 1311. CrossRef
Triglyceride-glucose index as a potential predictor for in-hospital mortality in critically ill patients with intracerebral hemorrhage: a multicenter, case–control study
Yang Yang, Shengru Liang, Jiangdong Liu, Minghao Man, Yue Si, Dengfeng Jia, Jianwei Li, Xiaoxi Tian, Lihong Li
BMC Geriatrics.2024;[Epub] CrossRef
Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice
Jiani Lu, Zhengshan Tang, Miaomiao Xu, Jianqiang Lu, Fengmei Wang, Xin Ni, Changnan Wang, Bo Yu
Redox Report.2024;[Epub] CrossRef
Significance of vitamin D responsiveness on the etiology of vitamin D-related diseases
Ulla M. Järvelin, Juho M. Järvelin
Steroids.2024; 207: 109437. CrossRef
Association between the triglyceride glucose index and obstructive sleep apnea and its symptoms: results from the NHANES
Chao Wang, Mengdi Shi, Chunsheng Lin, Jingyi Wang, Liangzhen Xie, Yan Li
Lipids in Health and Disease.2024;[Epub] CrossRef
Overweight, Obesity, Hypertriglyceridemia, and Insulin Resistance Are Positively Associated with High Serum Copper Levels in Mexican Adults
Armando Ramírez-Cruz, María Judith Rios-Lugo, Jacqueline Soto-Sánchez, Cuauhtémoc Arturo Juárez-Pérez, Alejandro Cabello-López, Carmina Jiménez-Ramírez, Consuelo Chang-Rueda, Miguel Cruz, Héctor Hernández-Mendoza, Miguel Vazquez-Moreno
Metabolites.2024; 14(5): 282. CrossRef
Therapeutic strategies targeting mechanisms of macrophages in diabetic heart disease
Chaoyue Zhang, Yunke Shi, Changzhi Liu, Shivon Mirza Sudesh, Zhao Hu, Pengyang Li, Qi Liu, Yiming Ma, Ao Shi, Hongyan Cai
Cardiovascular Diabetology.2024;[Epub] CrossRef
Global status and trends of metabolomics in diabetes: A literature visualization knowledge graph study
Hong Li, Liu Li, Qiu-Qing Huang, Si-Yao Yang, Jun-Ju Zou, Fan Xiao, Qin Xiang, Xiu Liu, Rong Yu
World Journal of Diabetes.2024; 15(5): 1021. CrossRef
Association of serum total IgE and allergen-specific IgE with insulin resistance in adolescents: an analysis of the NHANES database
Yaping Liu, Xiaoxia Wang, Yong Liu
BMC Pediatrics.2024;[Epub] CrossRef
A national study exploring the association between triglyceride-glucose index and risk of hyperuricemia events in adults with hypertension
Leixia Wang, Jianqian Chao, Na Zhang, Yanqian Wu, Min Bao, Chenyuan Yan, Tong Chen, Xinyue Li, Yiqin Chen
Preventive Medicine Reports.2024; 43: 102763. CrossRef
The association between triglyceride-glucose index and related parameters and risk of cardiovascular disease in American adults under different glucose metabolic states
Yuansong Zhuang, Liliang Qiu, Dongjian Han, Zhentao Qiao, Fuhang Wang, Qingjiao Jiang, Quanxu An, Yuhang Li, Jiahong Shangguan, Xuanye Bi, Deliang Shen
Diabetology & Metabolic Syndrome.2024;[Epub] CrossRef
Recent advances in the effect of adipose tissue inflammation on insulin resistance
Kaiyi Yan
Cellular Signalling.2024; 120: 111229. CrossRef
Umbilical Cord Mesenchymal Stem Cells Combined with Fufang Xueshuantong Capsule Attenuate Oxidative Stress and Vascular Lesions in Diabetic Rats by Activating Nrf-2/HO-1 Signaling Pathway
Yunchao Sun, Yongzhang Li, Xueliang Gao, Limin Gao, Bingqi Yang, Jianing Zhao
Endocrine, Metabolic & Immune Disorders - Drug Targets.2024; 24(8): 918. CrossRef
Harnessing Metabolic Indices as a Predictive Tool for Cardiovascular Disease in a Korean Population without Known Major Cardiovascular Event
Hyun-Jin Kim, Byung Sik Kim, Yonggu Lee, Sang Bong Ahn, Dong Wook Kim, Jeong-Hun Shin
Diabetes & Metabolism Journal.2024; 48(3): 449. CrossRef
Integrated insights into the synthesis and biological significances of novel benzofuran based oxadiazole/thiadiazole derivatives: A comprehensive computational and experimental study
Hakimullah, Zahoor Ullah, Wajid Rehman, Mamoon Ur Rashid, Shoaib Khan, Rafaqat Hussain, Yousaf Khan, Tayyiaba Iqbal, Shifa Felemban, M.M. Khowdiary
Journal of Molecular Structure.2024; 1314: 138726. CrossRef
Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review
Parisa Zare Mehrjerdi, Sara Asadi, Elham Ehsani, Vahid Reza Askari, Vafa Baradaran Rahimi
Naunyn-Schmiedeberg's Archives of Pharmacology.2024; 397(10): 7531. CrossRef
Application of ERAS in older patients with gastric cancer
Kuanxuan You, He Han
Medicine.2024; 103(22): e38409. CrossRef
Positive Effects of Physical Activity on Insulin Signaling
Paulina Małkowska
Current Issues in Molecular Biology.2024; 46(6): 5467. CrossRef
Preventing High Fat Diet-Induced Obesity and Related Hepatic Steatosis by Chlorin e6-Mediated Photodynamic Therapy
Pallavi Gurung, Junmo Lim, Yong-Wan Kim
Pharmaceuticals.2024; 17(6): 729. CrossRef
The Relationship Between Insulin Resistance Indicated by Triglyceride and Glucose Index and Left Ventricular Hypertrophy and Decreased Left Ventricular Diastolic Function with Preserved Ejection Fraction
Chengzhang Yang, Weifang Liu, Zijia Tong, Fang Lei, Lijin Lin, Xuewei Huang, Xingyuan Zhang, Tao Sun, Gang Wu, Huajing Shan, Shaoze Chen, Hongliang Li
Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 2259. CrossRef
Consumption of Chokeberry Bio-Products Improves Specific Metabolic Parameters and Increases the Plasma Antioxidant Status
Ewa Olechno, Anna Puścion-Jakubik, Katarzyna Socha, Caterina Pipino, Małgorzata Elżbieta Zujko
Antioxidants.2024; 13(6): 699. CrossRef
The ketogenic diet and MetSyn in Parkinson’s disease – Symptoms, biomarkers, depression and anxiety: A case study
Melanie M. Tidman
Journal of Metabolic Health.2024;[Epub] CrossRef
Bisphenol a accelerates the glucolipotoxicity-induced dysfunction of rat insulinoma cell lines: An implication for a potential risk of environmental bisphenol a exposure for individuals susceptible to type 2 diabetes
Chengmeng Huang, Xiaolin Chen, Zedong Ouyang, Lingxue Meng, Jian Liu, Qihua Pang, Ruifang Fan
Toxicology in Vitro.2024; 99: 105866. CrossRef
A randomized double blind placebo controlled trial to assess the safety and efficacy of a patented fenugreek (Trigonella foenum-graecum) seed extract in Type 2 diabetics
Rajinder Singh Gupta, Amarjit Singh Grover, Pawan Kumar, Apurva Goel, Samudra P. Banik, Sanjoy Chakraborty, Mehul Rungta, Manashi Bagchi, Partha Pal, Debasis Bagchi
Food & Nutrition Research.2024;[Epub] CrossRef
Ovalbumin Hydrolysates Enhance Skeletal Muscle Insulin-Dependent Signaling Pathway in High-Fat Diet-Fed Mice
Nesma Elhadad, S. C. de Campos Zani, C. B. Chan, Jianping Wu
Journal of Agricultural and Food Chemistry.2024; 72(27): 15248. CrossRef
Effects of Preoperative Oral Carbohydrates on Recovery After Laparoscopic Cholecystectomy: A Meta-analysis of Randomized Controlled Trials
Xiao-Han Wang, Ze-Yang Wang, Zheng-Ru Shan, Rui Wang, Zhi-Ping Wang
Journal of PeriAnesthesia Nursing.2024;[Epub] CrossRef
Metabolic Responses to High‐Fat Feeding and Chronic Psychological Stress Combination
Marzieh Nemati, Fatemeh Rostamkhani, Roxana Karbaschi, Homeira Zardooz
Endocrinology, Diabetes & Metabolism.2024;[Epub] CrossRef
Blue mussel (Mytilus edulis) lipid extract ameliorates insulin resistance in diabetic rats by regulating the SphK/So1P signaling pathway
Xiaotong Kuang, Shiyi Liu, Huiying Li, Xiaolei Song, Xianfeng Shao, Kelei Li, Duo Li
Journal of Functional Foods.2024; 119: 106307. CrossRef
Association between triglyceride glucose-body mass index and all-cause mortality in critically ill patients with acute myocardial infarction: retrospective analysis of the MIMIC-IV database
Chaodi Luo, Qian Li, Zhuoer Wang, Sifan Duan, Qiang Ma
Frontiers in Nutrition.2024;[Epub] CrossRef
High‐dose sinomenine attenuates ischemia/reperfusion‐induced hepatic inflammation and oxidative stress in rats with diabetes mellitus
Bo Hui, Xiaogang Zhang, Dinghui Dong, Yantao Shu, Ren Li, Zhengan Yang
Immunity, Inflammation and Disease.2024;[Epub] CrossRef
Endoplasmic reticulum stress in pancreatic β-cell dysfunctionality and diabetes mellitus: a promising target for generation of functional hPSC-derived β-cells in vitro
Abdoulaye Diane, Asma Allouch, Razik Bin Abdul Mu-U-Min, Heba Hussain Al-Siddiqi
Frontiers in Endocrinology.2024;[Epub] CrossRef
SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets
Luning Yang, Di Liu, Shide Jiang, Hengzhen Li, Lin Chen, Yuxiang Wu, Anko Elijah Essien, Michael Opoku, Shinen Naranmandakh, ShuGuang Liu, Qin Ru, Yusheng Li
Biomedicine & Pharmacotherapy.2024; 177: 116917. CrossRef
A Review of Fetal Development in Pregnancies with Maternal Type 2 Diabetes Mellitus (T2DM)-Associated Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysregulation: Possible Links to Pregestational Prediabetes
Mathuli Ngema, Nombuso D. Xulu, Phikelelani S. Ngubane, Andile Khathi
Biomedicines.2024; 12(6): 1372. CrossRef
The association between endometrial polyps and insulin resistance from the expression of PI3K and AKT proteins perspective
Xuelin Li, Feifan Wang, Mengzhu Chen, Li Ling, Fengfeng Zhao, Danhong Peng
BMC Women's Health.2024;[Epub] CrossRef
Sodium–Glucose Cotransporter Inhibitors: Cellular Mechanisms Involved in the Lipid Metabolism and the Treatment of Chronic Kidney Disease Associated with Metabolic Syndrome
Fernando Cortés-Camacho, Oscar René Zambrano-Vásquez, Elena Aréchaga-Ocampo, Jorge Ismael Castañeda-Sánchez, José Guillermo Gonzaga-Sánchez, José Luis Sánchez-Gloria, Laura Gabriela Sánchez-Lozada, Horacio Osorio-Alonso
Antioxidants.2024; 13(7): 768. CrossRef
The association of regional cerebral blood flow and glucose metabolism in normative ageing and insulin resistance
Hamish A. Deery, Emma Liang, Robert Di Paolo, Katharina Voigt, Gerard Murray, M. Navyaan Siddiqui, Gary F. Egan, Chris Moran, Sharna D. Jamadar
Scientific Reports.2024;[Epub] CrossRef
A comprehensive framework for managing metabolic dysfunction-associated steatotic liver disease: analyzing novel risk factors and advances in nanotechnology-based treatments and diagnosis
Lucia M. Chávez-López, Gabriela I. Carballo-López, Karina del Carmen Lugo-Ibarra, Ana B. Castro-Ceseña
RSC Medicinal Chemistry.2024; 15(8): 2622. CrossRef
Effect of oral glucose tolerance test-based insulin resistance on embryo quality in women with/without polycystic ovary syndrome
Zhengyan Hu, Rujun Zeng, Yuanting Tang, Yingjun Liao, Tao Li, Lang Qin
Frontiers in Endocrinology.2024;[Epub] CrossRef
Exogenous Nucleotides Ameliorate Insulin Resistance Induced by Palmitic Acid in HepG2 Cells through the IRS-1/AKT/FOXO1 Pathways
Lixia Song, Yong Li, Meihong Xu
Nutrients.2024; 16(12): 1801. CrossRef
Putative mechanism of a multivitamin treatment against insulin resistance
José Antonio Palma-Jacinto, Edgar López-López, José Luis Medina-Franco, Oreth Montero-Ruíz, Isela Santiago-Roque
Adipocyte.2024;[Epub] CrossRef
Insulin Resistance in Pediatric Obesity: From Mechanisms to Treatment Strategies
Yu Luo, Dan Luo, Maojun Li, Binzhi Tang, Robert P. Hoffman
Pediatric Diabetes.2024;[Epub] CrossRef
Lysophosphatidylcholine trigger myocardial injury in diabetic cardiomyopathy via the TLR4/ZNF480/AP-1/NF-kB pathway
Nannan Liu, Yang Chen, Tian An, Siyu Tao, Bohan Lv, Jinfang Dou, Ruxue Deng, Xianjie Zhen, Yuelin Zhang, Caizhong Lu, Zhongsheng Chang, Guangjian Jiang
Heliyon.2024; 10(13): e33601. CrossRef
John Yudkin’s hypothesis: sugar is a major dietary culprit in the development of cardiovascular disease
Kenneth K.Y. Ting
Frontiers in Nutrition.2024;[Epub] CrossRef
Rabson-Mendenhall Syndrome: Analysis of the Clinical Characteristics and Gene Mutations in 42 Patients
Wenfeng Gong, Wenzhe Chen, Jianjun Dong, Lin Liao
Journal of the Endocrine Society.2024;[Epub] CrossRef
Triglyceride glucose-related indexes and lipid accumulation products—reliable markers of insulin resistance in the Chinese population
Lei Liu, Yufang Luo, Min Liu, Chenyi Tang, Hong Liu, Guo Feng, Meng Wang, Jinru Wu, Wei Zhang
Frontiers in Nutrition.2024;[Epub] CrossRef
Exploring the active components and potential mechanisms of Alpiniae oxyphyllae Fructus in treating diabetes mellitus with depression by UPLC-Q-Exactive Orbitrap/MS, network pharmacology and molecular docking
Yue Qi, Qilun Zhou, Yongping Zhang, Jinlan Deng, Ruonan Li, Xiaofeng Zhang
Metabolic Brain Disease.2024; 39(6): 1065. CrossRef
A λ-Dynamics Investigation of Insulin Wakayama and Other A3 Variant Binding Affinities to the Insulin Receptor
Monica P. Barron, Jonah Z. Vilseck
Journal of Chemical Information and Modeling.2024; 64(14): 5657. CrossRef
The dichloromethane fraction from Calotropis gigantea (L.) dryand. Stem bark extract prevents liver cancer in SDT rats with insulin-independent diabetes mellitus
Thaiyawat Haewphet, Supawadee Parhira, Pattaraporn Chaisupasakul, Apirath Wangteeraprasert, Ittipon Phoungpetchara, Dumrongsak Pekthong, Worasak Kaewkong, Zhi-Hong Jiang, Li-Ping Bai, Julintorn Somran, Piyarat Srisawang
Journal of Ethnopharmacology.2024; 334: 118516. CrossRef
Association between preoperative persistent hyperglycemia and postoperative delirium in geriatric hip fracture patients
Wei Wang, Yingqi Zhang, Wei Yao, Wanyun Tang, Yuhao Li, Hongbo Sun, Wenbo Ding
BMC Geriatrics.2024;[Epub] CrossRef
Association between the triglyceride glucose index and the risk of acute kidney injury in critically ill patients with hypertension: analysis of the MIMIC-IV database
Wenbin Zhang, Zewen Yang
Frontiers in Endocrinology.2024;[Epub] CrossRef
The Role of Pro-Inflammatory Chemokines CCL-1, 2, 4, and 5 in the Etiopathogenesis of Type 2 Diabetes Mellitus in Subjects from the Asir Region of Saudi Arabia: Correlation with Different Degrees of Obesity
Mohammad Muzaffar Mir, Jaber Alfaifi, Shahzada Khalid Sohail, Syeda Fatima Rizvi, Md Tanwir Akhtar, Mushabab Ayed Abdullah Alghamdi, Rashid Mir, Javed Iqbal Wani, Zia Ul Sabah, Fahad A. Alhumaydhi, Fahad Alremthi, AbdulElah Al Jarallah AlQahtani, Muffarah
Journal of Personalized Medicine.2024; 14(7): 743. CrossRef
Endoplasmic reticulum stress mechanisms and exercise intervention in type 2 diabetes mellitus
Qianyu Chen, Xiaoqin Zhao, Zujie Xu, Yiyao Liu
Biomedicine & Pharmacotherapy.2024; 177: 117122. CrossRef
Advances in Nanomedicine for Precision Insulin Delivery
Alfredo Caturano, Roberto Nilo, Davide Nilo, Vincenzo Russo, Erica Santonastaso, Raffaele Galiero, Luca Rinaldi, Marcellino Monda, Celestino Sardu, Raffaele Marfella, Ferdinando Carlo Sasso
Pharmaceuticals.2024; 17(7): 945. CrossRef
Association between triglyceride glucose body mass index and cardiovascular disease in adults: evidence from NHANES 2011- 2020
Run Wang, Xiaobing Cheng, Weijun Tao
Frontiers in Endocrinology.2024;[Epub] CrossRef
Evaluating the impact of type 2 diabetes mellitus on pulmonary vascular function and the development of pulmonary fibrosis
Nhlakanipho Mzimela, Nosipho Dimba, Aubrey Sosibo, Andile Khathi
Frontiers in Endocrinology.2024;[Epub] CrossRef
Roles of Lysine Methylation in Glucose and Lipid Metabolism: Functions, Regulatory Mechanisms, and Therapeutic Implications
Zhen Wang, Huadong Liu
Biomolecules.2024; 14(7): 862. CrossRef
Slow-velocity eccentric-only resistance training improves symptoms of type 2 diabetic mellitus patients by regulating plasma MMP-2 and -9
Zhao Qian, Liu Ping, Xu Dongming, Zhang Xuelin
Medicine.2024; 103(29): e38855. CrossRef
Common Denominator of MASLD and Some Non-Communicable Diseases
Katarzyna Ferenc, Sara Jarmakiewicz-Czaja, Aneta Sokal-Dembowska, Katarzyna Stasik, Rafał Filip
Current Issues in Molecular Biology.2024; 46(7): 6690. CrossRef
Hepatokines: unveiling the molecular and cellular mechanisms connecting hepatic tissue to insulin resistance and inflammation
Xiaolei Miao, Arian Alidadipour, Vian Saed, Firooze Sayyadi, Yasaman Jadidi, Maryam Davoudi, Fatemeh Amraee, Nastaran Jadidi, Reza Afrisham
Acta Diabetologica.2024; 61(11): 1339. CrossRef
The cellular and molecular targets of natural products against metabolic disorders: a translational approach to reach the bedside
Xiaofei Shen, Hongling Yang, Yang Yang, Xianjun Zhu, Qingxiang Sun
MedComm.2024;[Epub] CrossRef
Impact of Lipids on Insulin Resistance: Insights from Human and Animal Studies
Rani Elkanawati, Sri Sumiwi, Jutti Levita
Drug Design, Development and Therapy.2024; Volume 18: 3337. CrossRef
Cysteine‐rich 61 inhibition attenuates hepatic insulin resistance and improves lipid metabolism in high‐fat diet fed mice and HepG2 cells
Yu Jung Heo, Jieun Park, Nami Lee, Sung‐E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Kwan Woo Lee, Hae Jin Kim
The FASEB Journal.2024;[Epub] CrossRef
Molecular mechanism and therapeutic strategy of bile acids in Alzheimer’s disease from the emerging perspective of the microbiota–gut–brain axis
Menglu Wu, Yongyi Cheng, Ruolin Zhang, Wenwen Han, Hanqi Jiang, Chenchen Bi, Ziyi Zhang, Mengfei Ye, Xiuqin Lin, Zheng Liu
Biomedicine & Pharmacotherapy.2024; 178: 117228. CrossRef
Deficiency of ASGR1 Alleviates Diet-Induced Systemic Insulin Resistance via Improved Hepatic Insulin Sensitivity
Xiaorui Yu, Jiawang Tao, Yuhang Wu, Yan Chen, Penghui Li, Fan Yang, Miaoxiu Tang, Abdul Sammad, Yu Tao, Yingying Xu, Yin-Xiong Li
Diabetes & Metabolism Journal.2024; 48(4): 802. CrossRef
Peripheral insulin resistance attenuates cerebral glucose metabolism and impairs working memory in healthy adults
Hamish A. Deery, Emma Liang, Robert Di Paolo, Katharina Voigt, Gerard Murray, M. Navyaan Siddiqui, Gary F. Egan, Chris Moran, Sharna D. Jamadar
npj Metabolic Health and Disease.2024;[Epub] CrossRef
Protein Arginine Methyltransferases: Emerging Targets in Cardiovascular and Metabolic Disease
Yan Zhang, Shibo Wei, Eun-Ju Jin, Yunju Jo, Chang-Myung Oh, Gyu-Un Bae, Jong-Sun Kang, Dongryeol Ryu
Diabetes & Metabolism Journal.2024; 48(4): 487. CrossRef
mTOR Dysregulation, Insulin Resistance, and Hypertension
Silviu Marcel Stanciu, Mariana Jinga, Daniela Miricescu, Constantin Stefani, Remus Iulian Nica, Iulia-Ioana Stanescu-Spinu, Ileana Adela Vacaroiu, Maria Greabu, Silvia Nica
Biomedicines.2024; 12(8): 1802. CrossRef
Advancing the understanding of diabetic encephalopathy through unravelling pathogenesis and exploring future treatment perspectives
Aarti Nagayach, Rakesh Bhaskar, Shampa Ghosh, Krishna Kumar Singh, Sung Soo Han, Jitendra Kumar Sinha
Ageing Research Reviews.2024; 100: 102450. CrossRef
Impact of Smoking and Obesity on the Selected Peptide Hormones and Metabolic Parameters in the Blood of Women with Polycystic Ovary Syndrome—Preliminary Study
Justyna Niepsuj, Agnieszka Piwowar, Grzegorz Franik, Anna Bizoń
International Journal of Molecular Sciences.2024; 25(16): 8713. CrossRef
Relationship between changes in the triglyceride glucose-body mass index and frail development trajectory and incidence in middle-aged and elderly individuals: a national cohort study
Kai Guo, Qi Wang, Lin Zhang, Rui Qiao, Yujia Huo, Lipeng Jing, Xiaowan Wang, Zixuan Song, Siyu Li, Jinming Zhang, Yanfang Yang, Jinli Mahe, Zhengran Liu
Cardiovascular Diabetology.2024;[Epub] CrossRef
In vitro digestive properties and the bioactive effect of walnut green husk on human gut microbiota
Xiaolan Zhao, Jiabao Ying, Zhuochen Wang, Yulu Wang, Zhen Li, Tianyi Gu, Shujun Liu, Yulong Li, Bing Liu, Fengjiao Xin, Boting Wen
Frontiers in Microbiology.2024;[Epub] CrossRef
Lipid on stroke in intracranial artery atherosclerotic stenosis: a mediation role of glucose
Sheng Li, Yiqing Wang, Xiangyi Zhu, He Zheng, Jianqiang Ni, Hao Li, Yi Yang
Frontiers in Endocrinology.2024;[Epub] CrossRef
Impact of Rice Bran Oil Emulsified Formulation on Digestion and Glycemic Response to Japonica Rice: An In Vitro Test and a Clinical Trial in Adult Men
Naoki Kawada, Keiko Kamachi, Masatsugu Tamura, Maki Tamura, Rika Kitamura, Kenta Susaki, Hiroyoshi Yamamoto, Hideaki Kobayashi, Ryosuke Matsuoka, Osamu Ishihara
Foods.2024; 13(16): 2628. CrossRef
Plant but not animal sourced nitrate intake is associated with lower dementia-related mortality in the Australian Diabetes, Obesity, and Lifestyle Study
Anjana Rajendra, Nicola P. Bondonno, Liezhou Zhong, Simone Radavelli-Bagatini, Kevin Murray, Stephanie R. Rainey-Smith, Samantha L. Gardener, Lauren C. Blekkenhorst, Dianna J. Magliano, Jonathan E. Shaw, Robin M. Daly, Kaarin J. Anstey, Joshua R. Lewis, J
Frontiers in Nutrition.2024;[Epub] CrossRef
İnsülin Direncinin Beslenme Tedavisinde Güncel Diyet Modelleri
Meryem Köpürlü, Elif Ede Çintesun
İstanbul Sabahattin Zaim Üniversitesi Fen Bilimleri Enstitüsü Dergisi.2024; 6(1): 5. CrossRef
Structural characterization, physicochemical properties and hypoglycemic activity of soluble dietary fibers from salt stressed mung bean sprouts
Cong Teng, Jinge Liu, Suling Li, Kaiyang Ma, Lujing Xu, Jin Feng, Zhi Chai, Xindi Hu, Yifei Lu, Ying Li
International Journal of Biological Macromolecules.2024; 278: 134979. CrossRef
The synergistic effect of triglyceride-glucose index and HbA1c on blood pressure control in patients with hypertension: a retrospective cohort study
Yugang Han, Jinghan Hai, Xiaojun Yang, Dongyue Lu, Jingyuan Li, Xuefang Yan, Peili Bu, Yun Ti, Xiaofeng Li
Scientific Reports.2024;[Epub] CrossRef
Nitric oxide in modulating oxidative stress mediated skeletal muscle insulin resistance
Aamir Anwar, Shivang Shukla, Priya Pathak
Molecular Biology Reports.2024;[Epub] CrossRef
Effect of weight loss interventions on metabolomic signatures in obese children with insulin resistance
Xiaoguang Liu, Lin Zhu, Jingxin Liu, Zichen Nie, Wenjun Qiu
Amino Acids.2024;[Epub] CrossRef
Mitochondrial dysfunction and onset of type 2 diabetes along with its complications: a multi-omics Mendelian randomization and colocalization study
Yang Li, Yahu Miao, Qing Feng, Weixi Zhu, Yijing Chen, Qingqing Kang, Zhen Wang, Fangting Lu, Qiu Zhang
Frontiers in Endocrinology.2024;[Epub] CrossRef
Molecular Aspects in the Development of Type 2 Diabetes and Possible Preventive and Complementary Therapies
Laura Simon-Szabó, Beáta Lizák, Gábor Sturm, Anikó Somogyi, István Takács, Zsuzsanna Németh
International Journal of Molecular Sciences.2024; 25(16): 9113. CrossRef
Effect of irisin on ovarian phosphatidylinositol‐3‐kinase/protein kinase B signaling pathway and mitogen‐activated protein kinase/extracellular signal‐regulated kinase pathways of rats with polycystic ovary syndrome
Cheng‐gang Li, Li Zhou, Ying‐jun Zhang, Yong Li, Li‐yan Zhao
Journal of Obstetrics and Gynaecology Research.2024; 50(10): 1945. CrossRef
Linear positive association of metabolic score for insulin resistance with stroke risk among American adults: a cross-sectional analysis of National Health and Nutrition Examination Survey datasets
Ruwen Zheng, Xu Dong, Tianyi Wang, Hongyan Zhang, Yihao Zhou, Dongyan Wang
Journal of Stroke and Cerebrovascular Diseases.2024; 33(11): 107994. CrossRef
Glycemic Control and Retinal Microvascular Changes in Type 2 Diabetes Mellitus Patients without Clinical Retinopathy
Kangmin Lee, Ga Hye Lee, Seung Eun Lee, Jee Myung Yang, Kunho Bae
Diabetes & Metabolism Journal.2024; 48(5): 983. CrossRef
The Predictive Value of the Triglycerides/HDL-Cholesterol Ratio for Diabetes Incidence
Bianca de Almeida-Pititto, Julia Ines Branda, Julia M. de Oliveira, Patrícia M. Dualib, Luisa Bittencourt de Aquino Fernandes Dias, Isabela M. Bensenor, Paulo A. Lotufo, Sandra Roberta G. Ferreira
Endocrines.2024; 5(3): 418. CrossRef
Associations of total protein, albumin, and globulin with insulin resistance: an NHANES study
Rui-Xiang Zeng, Jun-Peng Xu, Yu-Zhuo Zhang, Jia-Wei Tan, Yong-Jie Kong, Min-Zhou Zhang, Li-Heng Guo
Frontiers in Endocrinology.2024;[Epub] CrossRef
Sex-specific associations between total and regional Fat-to-muscle Mass ratio and cardiometabolic risk: findings from the China National Health Survey
Zhiming Lu, Yaoda Hu, Xingming Chen, Qiong Ou, Yawen Liu, Tan Xu, Ji Tu, Ang Li, Binbin Lin, Qihang Liu, Tianshu Xi, Weihao Wang, Haibo Huang, Da Xu, Zhili Chen, Zichao Wang, Huijing He, Guangliang Shan
Nutrition Journal.2024;[Epub] CrossRef
Genistein mitigates diet-induced obesity and metabolic dysfunctions in gonadectomized mice with some sex-differential effects
Weerapat Kositanurit, Natakorn Siritaweechai, Pachara Varachotisate, Chuti Burana, Narittee Sukswai, Jerasit Surintrspanont, Prasong Siriviriyakul, Kasiphak Kaikaew, Duangporn Werawatganon
Frontiers in Endocrinology.2024;[Epub] CrossRef
Initiating non-insulin-based treatment in adults with type 2 diabetes: a practical guide
Martha Stewart
Primary Health Care.2024;[Epub] CrossRef
Therapeutic Potential of Luteolin for Diabetes Mellitus and Its Complications
Xiao-qin Chang, Ren-song Yue
Chinese Journal of Integrative Medicine.2024;[Epub] CrossRef
Licochalcone D from Glycyrrhiza uralensis Improves High-Glucose-Induced Insulin Resistance in Hepatocytes
Yu Geon Lee, Hee Min Lee, Jin-Taek Hwang, Hyo-Kyoung Choi
International Journal of Molecular Sciences.2024; 25(18): 10066. CrossRef
The emerging role of nanoscaffolds in chronic diabetic wound healing: a new horizon for advanced therapeutics
Mehmet Ali Tibatan, Dzana Katana, Casey M. Yin
Journal of Biomaterials Science, Polymer Edition.2024; : 1. CrossRef
Bioactive molecules from soybeans (Glycine max) with anti-type 2 diabetes activity: a systematic review
Adekunle Babajide Rowaiye , Lorretha Chinonye Emenyonu, Ezinne Janefrances Nwonu, Okiemute Ajiroghene Okpalefe, Joseph Akwoba Ogugua , Victor Oluwatoyin Akinseye, Gordon Chukwuma Ibeanu
Academia Biology.2024;[Epub] CrossRef
Influence of Type 2 Diabetes and Adipose Tissue Dysfunction on Breast Cancer and Potential Benefits from Nutraceuticals Inducible in Microalgae
Domenico Sergi, Mattia Melloni, Angelina Passaro, Luca Maria Neri
Nutrients.2024; 16(19): 3243. CrossRef
Oxygen-Dependent Aspects of the Action of Asprosyn
V. V. Zinchuk, J. S. O. Al-Jebur
Rossijskij fiziologičeskij žurnal im. I.M. Sečenova.2024; 110(4): 547. CrossRef
How Can Promoting Skeletal Muscle Health and Exercise in Children and Adolescents Prevent Insulin Resistance and Type 2 Diabetes?
Valeria Calcaterra, Vittoria Carlotta Magenes, Alice Bianchi, Virginia Rossi, Alessandro Gatti, Luca Marin, Matteo Vandoni, Gianvincenzo Zuccotti
Life.2024; 14(9): 1198. CrossRef
Association between cardiometabolic index and gestational diabetes mellitus: a cross-sectional study
Minchun Chen, Suqiang Xiong, Jie Zheng, Jingyi Zhang, Dan Ye, Yusan Xian, Qing Cao, Kangkang Yan
Endocrine.2024;[Epub] CrossRef
Association between diabetes mellitus and ossification of the spinal ligament: a systematic review and meta-analysis
Bowen Lai, Yuan Gao, Yichen Meng, Rui Gao, Heng Jiang, Xuhui Zhou
Neurosurgical Review.2024;[Epub] CrossRef
Association of Insulin Resistance and Ectopic Fat Accumulation with HOMA Indices: A Single-Centre Observational Study
Sevde Nur Emir, Servet Emir
Turkish Journal of Diabetes and Obesity.2024; 8(2): 97. CrossRef
Enteropancreatic hormone changes in caloric-restricted diet interventions associate with post-intervention weight maintenance
Huibin Lin, Qiaoling Wang, Aibo Gao, Yingkai Sun, Chongrong Shen, Yufei Chen, Zhifeng Wang, Xiaoqiang Xu, Mengshan Ni, Yanru Chen, Juan Zhang, Yaogan Luo, Xu Lin, Yufang Bi, Guang Ning, Weiqing Wang, Jie Hong, Weiqiong Gu, Jiqiu Wang, Ruixin Liu
Clinical Nutrition.2024; 43(12): 5. CrossRef
Research Progress of the Correlation between Insulin Resistance and Its Novel Evaluation Indicators with Cardiovascular Disease
高华蒲
Advances in Clinical Medicine.2024; 14(10): 76. CrossRef
Hypoglycemic Effect of Rambutan (Nephelium lappaceum L.) Peel Polyphenols on Type 2 Diabetes Mice by Modulating Gut Microbiota and Metabolites
Qiuming Liu, Qingyu Ma, Jiao Li, Liping Sun, Yongliang Zhuang
Molecular Nutrition & Food Research.2024;[Epub] CrossRef
Gender Differences in the Predictive Value of Obesity Indices for Insulin Resistance in Adult Mexican Individuals
Elizalde-Barrera Cesar Ivan, Estrada-Garcia Teresa, Lopez-Saucedo Catalina, Rubio-Guerra Alberto Francisco, Ramirez-Velasco Diana Elena
Endocrine, Metabolic & Immune Disorders - Drug Targets.2024; 24(14): 1640. CrossRef
Association between Dietary Antioxidants and Atherosclerotic Cardiovascular Disease in South Korea: Insights from a Comprehensive Cross-Sectional Analysis
Jong-Ho Kim, Myeong Eun Lee, Sung-Mi Hwang, Jae-Jun Lee, Young-Suk Kwon
Journal of Clinical Medicine.2024; 13(20): 6068. CrossRef
Role of Akkermansia muciniphila in insulin resistance
Zhijun Zeng, Mengjie Chen, Yimin Liu, Yun Zhou, Hongning Liu, Shaohua Wang, Yanhua Ji
Journal of Gastroenterology and Hepatology.2024;[Epub] CrossRef
Elevated non-HDL-C to HDL-C ratio as a marker for NAFLD and liver fibrosis risk: a cross-sectional analysis
Yanyan Xuan, Minghui Zhu, Linzhi Xu, Shujiao Huangfu, Tongyu Li, Chunbo Liu, Dongdong Zhou
Frontiers in Endocrinology.2024;[Epub] CrossRef
Baicalein Ameliorates Insulin Resistance of HFD/STZ Mice Through Activating PI3K/AKT Signal Pathway of Liver and Skeletal Muscle in a GLP-1R-Dependent Manner
Na Liu, Xin Cui, Tingli Guo, Xiaotong Wei, Yuzhuo Sun, Jieyun Liu, Yangyang Zhang, Weina Ma, Wenhui Yan, Lina Chen
Antioxidants.2024; 13(10): 1246. CrossRef
Insulin
Wenqiang Chen, C. Ronald Kahn
Trends in Endocrinology & Metabolism.2024;[Epub] CrossRef
Prevalence of Functional Cobalamin Deficiency and Relevant Mortality Risk in the General Population: An Unheeded Phenotype Distinct from Cobalamin Deficiency
Yan Liu, Yi Gao, Yige Liu, Yiying Zhang, Shanjie Wang, Bo Yu
Journal of the American Nutrition Association.2024; : 1. CrossRef
Interaction between green tea and metformin and its effects on oxidative stress and inflammation in overweight women: a randomised clinical trial
Carolina de Oliveira Vogado, Monalisa Alves Ferreira, Eduardo Yoshio Nakano, Sabrina Azevedo, Kelly Grace Magalhães, Sandra Fernandes Arruda, Patrícia Borges Botelho
British Journal of Nutrition.2024; 132(9): 1173. CrossRef
The protective effects of fisetin in metabolic disorders: a focus on oxidative stress and associated events
Mahboobe Sattari, Jamal Amri, Mohammad Esmaeil Shahaboddin, Mohadese Sattari, Ozra Tabatabaei-Malazy, Marzyeh Azmon, Reza Meshkani, Ghodratollah Panahi
Journal of Diabetes & Metabolic Disorders.2024; 23(2): 1753. CrossRef
Early impaired insulin tolerance among Vietnamese diabetes with or without dyslipidemia
Mai Ly Thi Nguyen, Khac Cuong Bui, Thu Hang Ngo, Tai Suc Nguyen, Phuong Linh Thi Nham, Chi Pham, Thi Minh Hoang, Quang Thuan Huynh, Thanh Thuy Tang, Thanh Chung Dang, Thuy Linh Dang, Linh Toan Nguyen, Van Mao Can
Medicine.2024; 103(44): e40212. CrossRef
Exploration and identification of diabetes targets in nursing: CDH1 and DVL1
Fei Cheng, Lixia Li, Yanting Zhang
Medicine.2024; 103(44): e40002. CrossRef
KLF3 impacts insulin sensitivity and glucose uptake in skeletal muscle
Shuying Fu, Xiaocheng Gong, Keying Liang, Ke Ding, Li Qiu, Huice Cen, Hongli Du
American Journal of Physiology-Cell Physiology.2024; 327(5): C1219. CrossRef
Development and validation of a predictive scoring system for hypoglycaemic agents for optimal control of blood glucose during glucocorticoid therapy
Ayaka Kato, Masayuki Fuwa, Motochika Asano, Ichiro Mori, Saori Iida, Hideyuki Okada, Yoshihiro Uno, Kei Fujioka, Hiroyuki Morita
Internal Medicine Journal.2024; 54(12): 1970. CrossRef
Correlation between portal hypertension and somatic constitution: rationale behind the concept
Yury O. Zharikov, Ilia A. Voloshin, Roman V. Maslennikov, Aida N. Gadzhiakhmedova, Tatiana S. Zharikova, Vladimir N. Nikolenko
Science and Innovations in Medicine.2024; 9(4): 251. CrossRef
The association between the triglyceride-glucose index and vitamin D status: a systematic review and meta-analysis
Zhitong Li, Shiwei Liu, Xingyu Li, Jinchang Liu, Xin Li, Yuxiang Zhao, Yongliang Feng
BMC Endocrine Disorders.2024;[Epub] CrossRef
Varicose vein disease in the context of insulin resistance
Valeria Korolenya, Maxim Filipenko, Mariya Smetanina
Vessel Plus.2024;[Epub] CrossRef
Association of triglyceride-glucose index, low and high-density lipoprotein cholesterol with all-cause and cardiovascular disease mortality in generally Chinese elderly: a retrospective cohort study
Donghai Su, Zhantian An, Liyuan Chen, Xuejiao Chen, Wencan Wu, Yufang Cui, Yulin Cheng, Songhe Shi
Frontiers in Endocrinology.2024;[Epub] CrossRef
Targeting histamine in metabolic syndrome: Insights and therapeutic potential
Yiting Wang, Fude Fang, Xiaojun Liu
Life Sciences.2024; 358: 123172. CrossRef
Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin resistance in metabolic syndrome by regulating the LXRα/SREBP-1 signaling pathway
Sisi Lei, Weihang Peng, Lulu Wu, Liyuan Yu, Meida Wang, Qingmin Li, Yi Deng, Shuai Zhao, Peiying Huang, Bojun Chen
Frontiers in Pharmacology.2024;[Epub] CrossRef
Acupuncture, a Promising Therapy for Insulin Resistance and Non-Alcoholic Fatty Liver Disease
Hui Li, Dan Wang
International Journal of General Medicine.2024; Volume 17: 4917. CrossRef
Exploring cutting-edge approaches in diabetes care: from nanotechnology to personalized therapeutics
Gihan F. Asaad, Ahmed S. Doghish, Ahmed A. Rashad, Walaa A. El-Dakroury
Naunyn-Schmiedeberg's Archives of Pharmacology.2024;[Epub] CrossRef
Polysaccharides targeting autophagy to alleviate metabolic syndrome
Hongxia Li, Zeting Ye, Guangjuan Zheng, Zuqing Su
International Journal of Biological Macromolecules.2024; 283: 137393. CrossRef
Global burden of type 2 diabetes mellitus from 1990 to 2021, with projections of prevalence to 2044: a systematic analysis across SDI levels for the global burden of disease study 2021
Ke-Jie He, Haitao Wang, Jianguang Xu, Guoyu Gong, Xu Liu, Huiting Guan
Frontiers in Endocrinology.2024;[Epub] CrossRef
High-fiber basil seed flour reduces insulin resistance and hepatic steatosis in high-fat diet mice
Camila Farías, Camila Cisternas, Angie Caicedo, Lorena Mercado, Rodrigo Valenzuela, Héctor Calderón, Alejandra Espinosa, L. A. Videla, Loreto A. Muñoz
npj Science of Food.2024;[Epub] CrossRef
Ratio of red blood cell distribution width to albumin level and risk of mortality in sarcopenic obesity
Xiong-Bin Ma, Yan-Lin Lv, Lin Qian, Shi-Tao Huang, Xi-Xia Pu, Yong-Ming Liu
Scientific Reports.2024;[Epub] CrossRef
Diabetes and the associated complications: The role of antioxidants in diabetes therapy and care
Lowell Dilworth, Dewayne Stennett, Aldeam Facey, Felix Omoruyi, Shada Mohansingh, Felix O. Omoruyi
Biomedicine & Pharmacotherapy.2024; 181: 117641. CrossRef
The role of low-carbohydrate, high-fat diet in modulating autophagy and endoplasmic reticulum stress in aortic endothelial dysfunction of metabolic syndrome animal model
Basmah Eldakhakhny, Abdulhadi Bima, Aliaa A. Alamoudi, Abrar Alnami, Salwa Mohamed Abo-Elkhair, Hussein Sakr, Yousef Almoghrabi, Fatma Mohamed Ghoneim, Reham Mohamed Nagib, Ayman Elsamanoudy
Frontiers in Nutrition.2024;[Epub] CrossRef
Association between selenium biomarkers and insulin resistance in women with obesity: A case–control study
Tamires da Cunha Soares, Bruna Emanuele Pereira Cardoso, Thaline Milany da Silva Dias, Jennifer Beatriz Silva Morais, Larissa Cristina Fontenelle, Stéfany Rodrigues de Sousa Melo, Loanne Rocha dos Santos, Thayanne Gabryelle Visgueira de Sousa, Mickael de
Nutrition and Health.2024;[Epub] CrossRef
U-shaped relationship between triglyceride glucose-body mass index and suicide attempts in Chinese patients with untreated first-episode major depressive disorder
Fengnan Jia, He Ma, Junjun Liu, Chuanwei Li, Gang Ye, Tao Chen, Ruiping Huo, Xiangdong Du, Xiangyang Zhang
BMC Psychiatry.2024;[Epub] CrossRef
Expression of PPAR-γ TF by newly synthesized thiazolidine-2,4-diones to manage glycemic control: Insights from in silico, in vitro and experimental pharmacology in wistar rats
Shankar Gharge, Shankar G. Alegaon, Shriram D. Ranade, Rohini S. Kavalapure, B.R. Prashantha Kumar, Pravin C. Mhaske
Bioorganic Chemistry.2024; 153: 107966. CrossRef
Impact of diabetes mellitus on the risk of Alzheimer’s disease: a mendelian randomization study
Weichao Wang, Jie Zhang, Man Zhang, Chengyuan Zhang, Huanli Liu, Wanlin Li, Yimeng Fan
BMC Neurology.2024;[Epub] CrossRef
Chrysanthemum indicum L. ameliorates muscle atrophy by improving glucose tolerance in CT26-induced cancer cachexia
Gahee Song, Minji Choi, Woo Yong Park, Sang Hee Kim, Wenjun Jiao, Ja Yeon Park, Kwang Seok Ahn, Hyun Jeong Kwak, Jae-Young Um
Frontiers in Pharmacology.2024;[Epub] CrossRef
Associations of baseline and changes in the triglyceride glucose-weight adjusted waist index and cardiovascular disease risk: evidence from middle-aged and older individuals
Chenglin Duan, Meng Lyu, Jingjing Shi, Xintian Shou, Lu Zhao, Yuanhui Hu
Cardiovascular Diabetology.2024;[Epub] CrossRef
Correlation of the triglyceride-glucose index and heart rate with 28-day all-cause mortality in severely ill patients: analysis of the MIMIC-IV database
Yuekai Shao, Zhikun Gan, Taishan Wang, Zhiqiang Shao, Hong Yu, Song Qin, Hong Mei, Tao Chen, Xiaoyun Fu, Guoyue Liu, Miao Chen
Lipids in Health and Disease.2024;[Epub] CrossRef
Dysbiosis–epigenetics–immune system interaction and ageing health problems
Sima Ataollahi Eshkoor, Sara Fanijavadi
Journal of Medical Microbiology .2024;[Epub] CrossRef
A New Heterozygous Variant of c.1225_1227delTTC (p.Phe409del) in Insulin Receptor Gene Associated with Severe Insulin Resistance and Hyperandrogenemia in an Adolescent Female with Type A Severe Insulin Resistance Syndrome
Yuqing Song, Wenjie Lei, Qianqian Huang, Jiehan Zhang, Qiao Zhang, Lulu Chen, Huiqing Li, Li Liu, Tianshu Zeng, Xiang Hu
Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 4389. CrossRef
The impact of high-intensity interval training on insulin sensitivity and quality of life in women with overweight polycystic ovary syndrome
Ling Jiang, Yaxin Chen, Meiying Huang
Technology and Health Care.2024;[Epub] CrossRef
Relationship Between Body Composition and Insulin Resistance Evaluated by the TyG Index: A Retrospective Study Among Chinese Population
Yufang Luo, Lei Liu, Min Liu, Chenyi Tang, Hong Liu, Meng Wang, Guo Feng, Jinru Wu, Wei Wu
Clinical Endocrinology.2024;[Epub] CrossRef
Association Between Serum Concentrations of (Certain) Metals and Type 2 Diabetes Mellitus
Magdalena Tyczyńska, Gabriela Hunek, Weronika Kawecka, Adam Brachet, Marta Gędek, Kinga Kulczycka, Katarzyna Czarnek, Jolanta Flieger, Jacek Baj
Journal of Clinical Medicine.2024; 13(23): 7443. CrossRef
Exploring the Potential of Epigallocatechin Gallate in Combating Insulin Resistance and Diabetes
Kübra Yurtseven, Sevinç Yücecan
Nutrients.2024; 16(24): 4360. CrossRef
Insulin Resistance Predicts Prognosis in Patients With Subarachnoid Hemorrhage
Pengfei Ding, Dingding Zhang, Haiping Ling, Tao Tao, Yongyue Gao, Yunfeng Wang, Huasheng Zhang, Lingyun Wu, Chunhua Hang, Wei Li
Journal of Evidence-Based Medicine.2024; 17(4): 771. CrossRef
The waist-to-height ratio is a good predictor for insulin resistance in women with polycystic ovary syndrome
Mengyi Zhu, Kaiyue Wang, Jiaxing Feng, Yang Liu, Muxin Guan, Yu Wang, Xiaoke Wu
Frontiers in Endocrinology.2024;[Epub] CrossRef
Experimental cell models of insulin resistance: overview and appraisal
Ying Yang, Ting-ting Wang, Hu-ai Xie, Ping Ping Hu, Pan Li
Frontiers in Endocrinology.2024;[Epub] CrossRef
Association of non-insulin-dependent insulin resistance indices with lower limb artery restenosis after drug-coated balloon angioplasty
Zhentao Qiao, Yuansong Zhuang, Zhiwei Wang
Lipids in Health and Disease.2024;[Epub] CrossRef
The mediating role of vitamin D in the relationship between triglyceride glucose index and mortality in patients with diabetes mellitus: a causal mediation analysis
Fan Zhang, Wenjian Li
Frontiers in Nutrition.2024;[Epub] CrossRef
Polyethylene glycol loxenatide modulates lipid metabolism and insulin resistance through lncRNA steroid receptor RNA activator/cellular nucleic acid binding protein/Rho‐associated coiled‐coil kinase 2 axis in type 2 diabetes mellitus
Zhuangsen Chen, Zhongyu Zhou, Lin Wang, Yanrong Zhang, Caiyan Huang, Cong Wang, Ying Huang, Shanshan Wang, Dewen Yan, Kun Feng
Journal of Diabetes Investigation.2024;[Epub] CrossRef
Insulin resistance, vulnerable plaque and stroke risk in patients with carotid artery stenosis
Junjie Cao, Dayong Zhou, Zhichao Yao, Yuqi Zeng, Jin Zheng, Yao Tang, Jian Huang, Zhanao Liu, Guijun Huo
Scientific Reports.2024;[Epub] CrossRef
Interventions Targeting Insulin Resistance in Patients with Type 1 Diabetes: A Narrative Review
Andreea Herascu, Vlad-Florian Avram, Laura Gaita, Sima Alexandra, Delia-Viola Reurean-Pintilei, Bogdan Timar
Medicina.2024; 60(12): 2067. CrossRef
Association between triglyceride-glucose index and cardiovascular disease in US adults with chronic kidney disease: a population-based study
Lijia Liu, Hui Sun, Lan Yi, Gang Wang, Yanqin Zou
BMC Cardiovascular Disorders.2024;[Epub] CrossRef
Research hotspots and trends in diabetes and insulin resistance: a bibliometric analysis
Shaobo Zhang, Huixin Yan, Di Cao, Weichen Sun, Jingnan Li, Jing Xu, Bailin Song, Xingquan Wu
Frontiers in Nutrition.2024;[Epub] CrossRef
Correlations of the triglyceride−glucose index and modified indices with arterial stiffness in overweight or obese adults
Yuchen Tang, Li Li, Jialin Li
Frontiers in Endocrinology.2024;[Epub] CrossRef
A Comprehensive Review of Pathophysiological Link Between Non-alcoholic Fatty Liver Disease, Insulin Resistance, and Metabolic Syndrome
Eudith Januario, Aly Barakat, Abhivanditha Rajsundar, Zahra Fatima, Varda Nanda Palienkar, Arjun V Bullapur, Sunchandandeep Singh Brar, Punam Kharel, Mishal Mohammed Koyappathodi Machingal, Amena Backosh
Cureus.2024;[Epub] CrossRef
Gut Microbiota: An Important Participant in Childhood Obesity
Yu Luo, Maojun Li, Dan Luo, Binzhi Tang
Advances in Nutrition.2024; : 100362. CrossRef
Weight status influences the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy
Tao Tang, Xu-Sheng Zhao, Zhong-Jun Chen, Tie-Ping Fan, Aline M. Thomas, Man-Hong Zhao, Di Li, Shen Li
Brain Circulation.2024; 10(4): 324. CrossRef
The Therapeutic Role of Gastrodin in Combating Insulin Resistance, Inflammation, and Oxidative Stress Induced by Bisphenol-A
Obasi U. Orji, Nonso J. Awoke, Daniel E. Uti, Otuomasirichi D. Obasi, Patrick M. Aja, Ezeaani N. Nwamaka, Grace Ufedo Umoru, Patience N. Ogbu, Mfon Paulinus Udoudoh, Esther U. Alum, Celestine O. Ogbu, Simon I. Oodo, Udu A. Ibiam
Natural Product Communications.2024;[Epub] CrossRef
Lauric-α-linolenic lipids modulate gut microbiota, preventing obesity, insulin resistance and inflammation in high-fat diet mice
Ying Huang, Wangxin Liu, Xianliang Luo, Minjie Zhao, Jing Wang, Sami Ullah, Wei Wei, Fengqin Feng
npj Science of Food.2024;[Epub] CrossRef
The Predictive Value of TyG Index and NLR for Risk of CHD and the Severity of Coronary Artery Lesions in Patients with Type 2 Diabetes Mellitus
Haixia Li, Mingxian Chen, Youhua Wang, Weilu Cui, Yuqing Lou, Dong Chen, Haiming Deng, Zican Shen
Journal of Inflammation Research.2024; Volume 17: 11813. CrossRef
Prevalence of Metabolic Syndrome and Insulin Resistance in Adult Patients with Acne: Association with Traditional Cardiovascular Risk Factors and Acne Severity
Ana Cecília Arcanjo Carneiro, Jozélio Freire de Carvalho, Daniel Coelho de Sá, Carlos Ewerton Maia Rodrigues
Metabolic Syndrome and Related Disorders.2023; 21(2): 109. CrossRef
Metabolic and Genetic Association of Vitamin D with Calcium Signaling and Insulin Resistance
Najeebul Tarfeen, Khair Ul Nisa, Mir Bilal Ahmad, Ajaz Ahmad Waza, Bashir Ahmad Ganai
Indian Journal of Clinical Biochemistry.2023; 38(4): 407. CrossRef
Tinosporaside from Tinospora cordifolia Encourages Skeletal Muscle Glucose Transport through Both PI-3-Kinase- and AMPK-Dependent Mechanisms
Akansha Mishra, Khushbu Sharma, Jyotsana Pandey, Kapil Dev, Sleman Kadan, Mahendra Sahai, Ishbal Ahmad, Arvind K. Srivastava, Akhilesh K. Tamrakar, Hilal Zaid, Rakesh Maurya
Molecules.2023; 28(2): 483. CrossRef
Pathophysiology of obesity and its associated diseases
Xin Jin, Tingting Qiu, Li Li, Rilei Yu, Xiguang Chen, Changgui Li, Christopher G. Proud, Tao Jiang
Acta Pharmaceutica Sinica B.2023; 13(6): 2403. CrossRef
Hypertension, type 2 diabetes, obesity, and p53 mutations negatively correlate with metastatic colorectal cancer patients’ survival
Alessandro Ottaiano, Mariachiara Santorsola, Luisa Circelli, Francesco Perri, Marco Cascella, Francesco Sabbatino, Maurizio Capuozzo, Vincenza Granata, Silvia Zappavigna, Angela Lombardi, Marianna Scrima, Nadia Petrillo, Monica Ianniello, Marika Casillo,
Frontiers in Medicine.2023;[Epub] CrossRef
Triglyceride glucose index and poor sleep patterns in non-diabetic adults: Evidence from NHANES 2005–2016
Chi-Feng Liu, Li-Wei Chien
Frontiers in Nutrition.2023;[Epub] CrossRef
Polyphenol-Rich Extract of Fermented Chili Pepper Alleviates Insulin Resistance in HepG2 Cells via Regulating INSR, PTP1B, PPAR-γ, and AMPK Pathways
Tao Wang, Meiqi Li, Shengbao Cai, Linyan Zhou, Xiaosong Hu, Junjie Yi
Fermentation.2023; 9(2): 84. CrossRef
Effects of preoperative oral enzyme-hydrolyzed rice flour solution on gastric emptying and insulin resistance in patients undergoing laparoscopic cholecystectomy: a prospective randomized controlled trial
Yang Yuan, Guangjun Shi, Huailong Chen, Mingshan Wang, Haofei Liu, Xiao Zhang, Bin Wang, Gaofeng Zhang, Lixin Sun
BMC Anesthesiology.2023;[Epub] CrossRef
Roles of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome
Hiroshi Koike, Miyuki Harada, Akari Kusamoto, Zixin Xu, Tsurugi Tanaka, Nanoka Sakaguchi, Chisato Kunitomi, Jerilee M. K. Azhary, Nozomi Takahashi, Yoko Urata, Yutaka Osuga
Frontiers in Endocrinology.2023;[Epub] CrossRef
The Metabolic Score for Insulin Resistance (METS-IR) Predicts Cardiovascular Disease and Its Subtypes in Patients with Hypertension and Obstructive Sleep Apnea
Wenbo Yang, Xintian Cai, Junli Hu, Wen Wen, Heizhati Mulalibieke, Xiaoguang Yao, Ling Yao, Qing Zhu, Jing Hong, Qin Luo, Shasha Liu, Nanfang Li
Clinical Epidemiology.2023; Volume 15: 177. CrossRef
Sperm DNA damage: The possible link between obesity and male infertility, an update of the current literature
Andrew Peel, Anmol Saini, Joshua C. Deluao, Nicole O. McPherson
Andrology.2023; 11(8): 1635. CrossRef
Glucose Homeostasis, Diabetes Mellitus, and Gender-Affirming Treatment
Charalampos Milionis, Ioannis Ilias, Evangelia Venaki, Eftychia Koukkou
Biomedicines.2023; 11(3): 670. CrossRef
From Metabolic Syndrome to Type 2 Diabetes in Youth
Dario Iafusco, Roberto Franceschi, Alice Maguolo, Salvatore Guercio Nuzio, Antonino Crinò, Maurizio Delvecchio, Lorenzo Iughetti, Claudio Maffeis, Valeria Calcaterra, Melania Manco
Children.2023; 10(3): 516. CrossRef
Kcnma1 is involved in mitochondrial homeostasis in diabetes‐related skeletal muscle atrophy
Shan‐Yan Gao, Yong‐Ping Liu, Ri Wen, Xin‐Mei Huang, Ping Li, Yu‐Hang Yang, Ni Yang, Tie‐Ning Zhang
The FASEB Journal.2023;[Epub] CrossRef
Capsaicin and Zinc Signalling Pathways as Promising Targets for Managing Insulin Resistance and Type 2 Diabetes
Parisa Vahidi Ferdowsi, Kiran D. K. Ahuja, Jeffrey M. Beckett, Stephen Myers
Molecules.2023; 28(6): 2861. CrossRef
Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption
Keiko Unno, Kyoko Taguchi, Yoshiichi Takagi, Tadashi Hase, Shinichi Meguro, Yoriyuki Nakamura
International Journal of Molecular Sciences.2023; 24(7): 6278. CrossRef
Association between triglyceride-glucose index and carotid atherosclerosis in patients with psoriatic arthritis
Wenhui Xie, Wei Bian, Zhibo Song, Xuerong Deng, Jiahao Qu, Zhuoli Zhang
Rheumatology.2023; 62(11): 3584. CrossRef
The relationship between HMGB1 and autophagy in the pathogenesis of diabetes and its complications
Kun Yang, Feng Cao, Weili Wang, Zhenyu Tian, Lu Yang
Frontiers in Endocrinology.2023;[Epub] CrossRef
Association of long-term triglyceride-glucose index level and change with the risk of cardiometabolic diseases
Wenqi Xu, Haiyan Zhao, Lishu Gao, Lu Guo, Jianrong Liu, Haixia Li, Junyan Sun, Aijun Xing, Shuohua Chen, Shouling Wu, Yuntao Wu
Frontiers in Endocrinology.2023;[Epub] CrossRef
White Adipose Tissue Dysfunction: Pathophysiology and Emergent Measurements
Natalia Santillana, Camila Astudillo-Guerrero, Amanda D’Espessailles, Gonzalo Cruz
Nutrients.2023; 15(7): 1722. CrossRef
Soy protein compared with whey protein ameliorates insulin resistance by regulating lipid metabolism, AMPK/mTOR pathway and gut microbiota in high-fat diet-fed mice
Andong Ji, Wei Chen, Chang Liu, Tianyu Zhang, Runjia Shi, Xinqi Wang, Huina Xu, Duo Li
Food & Function.2023; 14(12): 5752. CrossRef
Hepatic Insulin Resistance Model in the Male Wistar Rat Using Exogenous Insulin Glargine Administration
Victor Enrique Sarmiento-Ortega, Diana Moroni-González, Alfonso Diaz, Miguel Ángel García-González, Eduardo Brambila, Samuel Treviño
Metabolites.2023; 13(4): 572. CrossRef
Pathophysiological Effects of Contemporary Lifestyle on Evolutionary-Conserved Survival Mechanisms in Polycystic Ovary Syndrome
Jim Parker
Life.2023; 13(4): 1056. CrossRef
Metabolic dysfunction correction as a method of restoring the function of the reproductive system in women
G. E. Chernukha, V. A. Pronina
Meditsinskiy sovet = Medical Council.2023; (5): 90. CrossRef
Associations between TyG-BMI and normal-high blood pressure values and hypertension: cross-sectional evidence from a non-diabetic population
Nan Peng, Maobin Kuang, Yi Peng, Hang Yu, Shuhua Zhang, Guobo Xie, Guotai Sheng, Yang Zou
Frontiers in Cardiovascular Medicine.2023;[Epub] CrossRef
Inverse Correlation of Superoxide Dismutase and Catalase with Type 2 Diabetes among Rural Thais
Natnicha Promyos, Pornpimol Panprathip Phienluphon, Naruemon Wechjakwen, Jirayu Lainampetch, Pattaneeya Prangthip, Karunee Kwanbunjan
Nutrients.2023; 15(9): 2071. CrossRef
Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
Min Jeong Park, Kyung Mook Choi
Metabolism.2023; 144: 155577. CrossRef
Oxygen-binding properties of blood in insulin resistance with different asprosin content
V.V. Zinchuk, J.S.O. Al-Jebur, N.V. Glutkina
Biomeditsinskaya Khimiya.2023; 69(2): 133. CrossRef
Associations between basal metabolic rate and insulin resistance in non-diabetic obese adults: Evidence from NHANES 2011–2018
Hai Guo, Dilihumaier Duolikun, Qiaoling Yao
International Journal of Diabetes in Developing Countries.2023; 43(6): 946. CrossRef
Biomarkers of Spinal Cord Injury in Patients Undergoing Complex Endovascular Aortic Repair Procedures—A Narrative Review of Current Literature
Anna Sotir, Johannes Klopf, Christine Brostjan, Christoph Neumayer, Wolf Eilenberg
Biomedicines.2023; 11(5): 1317. CrossRef
The Hypoglycemic Activities and Underlying Mechanisms of Two Saponins‐Rich Components from Fried Ziziphus jujuba Mill. Kernel
Yi‐Meng Li, Ke‐xin Hao, Hong Xie, Jian‐Guo Jiang
Molecular Nutrition & Food Research.2023;[Epub] CrossRef
Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia
Yi-Shang Yan, Chun Feng, Dan-Qing Yu, Shen Tian, Yin Zhou, Yi-Ting Huang, Yi-Ting Cai, Jian Chen, Miao-Miao Zhu, Min Jin
Frontiers in Nutrition.2023;[Epub] CrossRef
The Function of MondoA and ChREBP Nutrient—Sensing Factors in Metabolic Disease
Byungyong Ahn
International Journal of Molecular Sciences.2023; 24(10): 8811. CrossRef
An Update on the Molecular and Cellular Basis of Pharmacotherapy in Type 2 Diabetes Mellitus
Mohamed Omer Mahgoub, Ifrah Ismail Ali, Jennifer O. Adeghate, Kornélia Tekes, Huba Kalász, Ernest A. Adeghate
International Journal of Molecular Sciences.2023; 24(11): 9328. CrossRef
Study on the therapeutic effect and mechanism of Tangningtongluo Tablet on diabetic mice
Zengxiaorui Cai, Xiangka Hu, Liuming Gui, Mushuang Qi, Wanjun Zhu, Ying Ren, Shuyu Yang, Chunmei Dai
Journal of Diabetes and its Complications.2023; 37(8): 108523. CrossRef
A Descriptive Review of the Action Mechanisms of Berberine, Quercetin and Silymarin on Insulin Resistance/Hyperinsulinemia and Cardiovascular Prevention
Paolo Bellavite, Serafino Fazio, Flora Affuso
Molecules.2023; 28(11): 4491. CrossRef
Relationships of neck circumference and abdominal obesity with insulin resistance considering relative handgrip strength in middle-aged and older individuals
Kayoung Lee
Archives of Gerontology and Geriatrics.2023; 114: 105097. CrossRef
Acute exposure to realistic concentrations of Bisphenol-A trigger health damage in fish: Blood parameters, gene expression, oxidative stress
Gustavo Axel Elizalde-Velázquez, Leobardo Manuel Gómez-Oliván, Selene Elizabeth Herrera-Vázquez, Karina Elisa Rosales-Pérez, Nely SanJuan-Reyes, Sandra García-Medina, Marcela Galar-Martínez
Aquatic Toxicology.2023; 261: 106610. CrossRef
Gαi‐coupled GPR41 activation increases Ca2+ influx in C2C12 cells and shows a therapeutic effect in diabetic animals
Do‐Hyung Lee, Kyung‐Sun Heo, Chang‐Seon Myung
Obesity.2023; 31(7): 1871. CrossRef
Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in mice
Saori Kakehi, Yoshifumi Tamura, Shin-ichi Ikeda, Naoko Kaga, Hikari Taka, Yuya Nishida, Ryuzo Kawamori, Hirotaka Watada
Frontiers in Physiology.2023;[Epub] CrossRef
Metabolic-Associated Fatty Liver Disease and Insulin Resistance: A Review of Complex Interlinks
Thomas M. Barber, Stefan Kabisch, Andreas F. H. Pfeiffer, Martin O. Weickert
Metabolites.2023; 13(6): 757. CrossRef
Metabolic Markers Associated with Progression of Type 2 Diabetes Induced by High-Fat Diet and Single Low Dose Streptozotocin in Rats
Maria Andonova, Petko Dzhelebov, Krastina Trifonova, Penka Yonkova, Nikola Kostadinov, Krasimira Nancheva, Veselin Ivanov, Krasimira Gospodinova, Nikola Nizamov, Ilia Tsachev, Chavdar Chernev
Veterinary Sciences.2023; 10(7): 431. CrossRef
Research Progress Into Adipose Tissue Macrophages and Insulin Resistance
M Fu, L Yang, H Wang, Y Chen, X Chen, Q Hu, H Sun
Physiological Research.2023;[Epub] CrossRef
Effects of aerobic exercises in prediabetes patients: a systematic review and meta-analysis
Yifei Wang, Honglei Li, Dongxue Yang, Mengzhao Wang, Yanbai Han, Hongli Wang
Frontiers in Endocrinology.2023;[Epub] CrossRef
Associations of C-peptide with cardiometabolic parameters in women aged 25–44 years with different metabolic phenotypes
S. V. Mustafina, V. I. Alferova, L. V. Shcherbakova, E. V. Kashtanova, D. V. Denisova
Ateroscleroz.2023; 19(2): 115. CrossRef
Adipose-derived Mesenchymal Stem Cells Therapy as a new Treatment Option for Diabetes Mellitus
Agnieszka Mikłosz, Adrian Chabowski
The Journal of Clinical Endocrinology & Metabolism.2023; 108(8): 1889. CrossRef
Anthropometric Indices With Insulin Resistance in Obese Patients: A Literature Review
Khalid Khan, Anil Wanjari, Sourya Acharya, Sabiha Quazi
Cureus.2023;[Epub] CrossRef
Preventive and therapeutic effects of natural products and herbal extracts onnonalcoholic fatty liver disease/nonalcoholic steatohepatitis
Yiming Cao, Xiaoxue Fang, Mingyang Sun, Yegang Zhang, Mengyao Shan, Xintian Lan, Difu Zhu, Haoming Luo
Phytotherapy Research.2023; 37(9): 3867. CrossRef
Tuina (Chinese massage) for insulin resistance and sensitivity: A protocol for systematic review and meta-analysis of animal and human studies
Zhixuan Zhao, Jun Yan, Yuxin Ding, Yingji Wang, Yan Li, Ricardo Ney Oliveira Cobucci
PLOS ONE.2023; 18(7): e0288414. CrossRef
Rubus chingii Hu relieved the polycystic ovary syndrome with enhanced insulin sensitivity through inhibiting TXNIP/NLRP3 inflammasome signaling
Huizhen Li, Yongping Li, Ying Zhang, Li Tong, Yuping Sa, Wenping Sun
Gynecological Endocrinology.2023;[Epub] CrossRef
The Research Role of Triglyceride Glucose Index in Pre-Type 2 Diabetes
士博徐
Advances in Clinical Medicine.2023; 13(07): 11762. CrossRef
Gentiopicroside modulates glucose homeostasis in high-fat-diet and streptozotocin-induced type 2 diabetic mice
Xing Wang, Dongmei Long, Xianghong Hu, Nan Guo
Frontiers in Pharmacology.2023;[Epub] CrossRef
Review of the Case Reports on Metformin, Sulfonylurea, and Thiazolidinedione Therapies in Type 2 Diabetes Mellitus Patients
Elis Susilawati, Jutti Levita, Yasmiwar Susilawati, Sri Adi Sumiwi
Medical Sciences.2023; 11(3): 50. CrossRef
Effects of AIM2 and IFI16 on Infectious Diseases and Inflammation
Zhen Fan, Rui Chen, Wen Yin, Xiaomei Xie, Shan Wang, Chunbo Hao
Viral Immunology.2023; 36(7): 438. CrossRef
PREDICTING PROGRESSION TYPE 2 DIABETES MELLITUS: A 3-YEAR FOLLOW-UP STUDY EXAMINING RISK FACTORS FOR TYPE 2 DIABETES IN PATIENTS WITH PREDIABETES
Taras I. Griadil, Mykhaylo V. Bychko, Mykhaylo M. Hechko, Ksenia I. Chubirko, Ivan V. Chopey
Polski Merkuriusz Lekarski.2023; 51(3): 245. CrossRef
GABA Prevents Age-Related Sarcopenic Obesity in Mice with High-Fat-Diet-Induced Obesity
Heegu Jin, Hyun-Ji Oh, Boo-Yong Lee
Cells.2023; 12(17): 2146. CrossRef
Bio-Hacking Better Health—Leveraging Metabolic Biochemistry to Maximise Healthspan
Isabella D. Cooper, Yvoni Kyriakidou, Lucy Petagine, Kurtis Edwards, Bradley T. Elliott
Antioxidants.2023; 12(9): 1749. CrossRef
Hyperinsulinemia Impairs Clathrin-Mediated Endocytosis of the Insulin Receptor and Activation of Endothelial Nitric Oxide Synthase in Brain Endothelial Cells
Stephanie G. DiLucia, B. Jacob Kendrick, Catrina Sims-Robinson
International Journal of Molecular Sciences.2023; 24(19): 14670. CrossRef
Flavonoids from Lophatherum gracile Brongn. Ameliorate Liver Damages in High-Fat Diet and Streptozotocin-Induced Diabetic Mice by Regulating PI3K/AKT and NF-Kappa B Pathways
Jian-Hua Zheng, Song-Xia Lin, Xiao-Yi Li, Chun-Yan Shen, Shao-Wei Zheng, Wen-Bin Chen, Walid Elfalleh
Journal of Food Biochemistry.2023; 2023: 1. CrossRef
Asprosin, a novel glucogenic adipokine implicated in type 2 diabetes mellitus
Hongcui Diao, Xue Li, Yeqiu Xu, Xiuli Xing, Shuguang Pang
Journal of Diabetes and its Complications.2023; 37(11): 108614. CrossRef
Impact of Fixed Combination of Metformin and Pioglitazone on Insulin Resistance of Patients with Type 2 Diabetes: Results of a Randomized Open-Label Study
Rui Sun, Lu Yuan, Yun Shen, Ziyang Shen, Bo Ding, Jianhua Ma
Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 2911. CrossRef
Integrating network analysis and experimental validation to reveal the mechanism of pinocembrin in alleviating high glucose and free fatty acid-induced lipid accumulation in HepG2 cells
Kun Hu, Yongjin Sun, Jie Wang, Shaojun Wu, Jie Ren, Dan Su, Lidan Tang, Jinhong Gong, Hufeng Fang, Shan Xu, Hao Yang
Journal of Functional Foods.2023; 110: 105879. CrossRef
A Literature Review and a Proposed Classification of the Relationships between Ovulatory Infertility and Lifestyle Factors Based on the Three Groups of Ovulation Disorders Classified by WHO
Magdalena Skowrońska, Michał Pawłowski, Robert Milewski
Journal of Clinical Medicine.2023; 12(19): 6275. CrossRef
Targeting of insulin receptor endocytosis as a treatment to insulin resistance
Bryce Tim, Valentina L. Kouznetsova, Santosh Kesari, Igor F. Tsigelny
Journal of Diabetes and its Complications.2023; 37(11): 108615. CrossRef
A U-shaped association between the triglyceride to high-density lipoprotein cholesterol ratio and the risk of incident type 2 diabetes mellitus in Japanese men with normal glycemic levels: a population-based longitudinal cohort study
Bei Song, Kun Wang, Weilin Lu, Xiaofang Zhao, Tianci Yao, Ting Liu, Guangyu Gao, Haohui Fan, Chengyun Liu
Frontiers in Endocrinology.2023;[Epub] CrossRef
Association of triglyceride-glucose index levels with gestational diabetes mellitus in the US pregnant women: a cross-sectional study
Yan Zeng, Li Yin, Xiaoping Yin, Danqing Zhao
Frontiers in Endocrinology.2023;[Epub] CrossRef
The protective role of resveratrol in diabetic wound healing
Minglei Bi, Yonghong Qin, Lerong Wang, Jin Zhang
Phytotherapy Research.2023; 37(11): 5193. CrossRef
Correlation between alternative insulin resistance indexes and diabetic kidney disease: a retrospective study
Xiaodie Mu, Aihua Wu, Huiyue Hu, Min Yang, Hua Zhou
Endocrine.2023; 84(1): 136. CrossRef
Enhancing Muscle Intracellular Ca2+ Homeostasis and Glucose Uptake: Passive Pulsatile Shear Stress Treatment in Type 2 Diabetes
Arkady Uryash, Jordan Umlas, Alfredo Mijares, Jose A. Adams, Jose R. Lopez
Biomedicines.2023; 11(10): 2596. CrossRef
Review of Related Research on Type 2 Diabetes Related Macroangiopathy
珊珊李
Advances in Clinical Medicine.2023; 13(09): 15001. CrossRef
Association between lipoprotein(a) and insulin resistance in Chinese adults: results from the China health and nutrition survey
Heng Wang, Jia-Li Fan
Frontiers in Endocrinology.2023;[Epub] CrossRef
Association between the Triglyceride–Glucose Index and Non-Alcoholic Fatty Liver Disease in patients with Atrial Fibrillation
Xiaozhong Li, Fenfang Zhan, Tian Peng, Zhen Xia, Juxiang Li
European Journal of Medical Research.2023;[Epub] CrossRef
Resveratrol as a potential protective compound against skeletal muscle insulin resistance
Arash Bahramzadeh, Kosar Bolandnazar, Reza Meshkani
Heliyon.2023; 9(11): e21305. CrossRef
The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging
Zheng Ding, Yuqiu Wei, Jing Peng, Siyu Wang, Guixi Chen, Jiazeng Sun
Biomedicines.2023; 11(10): 2711. CrossRef
Obesity and Bone Mineral Density Protection Paradox in Chronic Kidney Disease: Secreted Protein Acidic and Rich in Cysteine as a Piece of the Puzzle?
Abdelaziz Ghanemi, Fabrice Mac-Way
Life.2023; 13(11): 2172. CrossRef
Correlation of Lipid Profile and Apolipoprotein B/A-I Ratio with Insulin Resistance in Non-Diabetes Mellitus Subjects
Andi Heriadi Palloge, Liong Boy Kurniawan, Yuyun Widyaningsih, Husaini Umar, Nurahmi Nurahmi, Andi Alfian Zainuddin
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY.2023; 30(1): 6. CrossRef
Endothelial progenitor cells as biomarkers of diabetes-related cardiovascular complications
Josefa Benítez-Camacho, Antonio Ballesteros, Lucía Beltrán-Camacho, Marta Rojas-Torres, Antonio Rosal-Vela, Margarita Jimenez-Palomares, Ismael Sanchez-Gomar, Mª Carmen Durán-Ruiz
Stem Cell Research & Therapy.2023;[Epub] CrossRef
Effects of ginseng peptides on the hypoglycemic activity and gut microbiota of a type 2 diabetes mellitus mice model
Caijing Han, Xiaoting Kong, Xiaohong Xia, Xinyu Huang, Zhaojie Mao, Jiaxin Han, Fuyan Shi, Yaohui Liang, Anning Wang, Fengxiang Zhang
Journal of Functional Foods.2023; 111: 105897. CrossRef
Effects of theasaponin E1 on the regulationglucose uptake of C2C12 myoblasts PI3K/Akt/mTOR signaling pathway
Ming Zhang, Zhiyun Chen, Di Tian, Zaiqiao Li, Shaning Wang, Yujie Huo, Ling Song, Juan Lu, Jun Sheng, Xu Ji, Xiao Ma
CyTA - Journal of Food.2023; 21(1): 682. CrossRef
Efficacy and underlying mechanisms of berberine against lipid metabolic diseases: a review
Yajie Cai, Qiaoning Yang, Yanqiao Yu, Furong Yang, Ruina Bai, Xiaodi Fan
Frontiers in Pharmacology.2023;[Epub] CrossRef
Adipocyte-derived exosomal miR-22-3p modulated by circadian rhythm disruption regulates insulin sensitivity in skeletal muscle cells
Haohao Zhang, Xiaoning Zhang, Saifei Wang, Lu Zheng, Hengru Guo, Yanqi Ren, Bo Qiao, Jing Wu, Di Zhao, Lijun Xu, Shengnan Ma, Xiao Hao, Yushan Yan
Journal of Biological Chemistry.2023; 299(12): 105476. CrossRef
Total Astragalus saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance in vivo
Leilei Ma, Xiaojin La, Biwei Zhang, Wenxuan Xu, Chunyu Tian, Qianru Fu, Meng Wang, Chenxi Wu, Zhen Chen, Hong Chang, Ji-an Li
Frontiers in Endocrinology.2023;[Epub] CrossRef
Interplay between Vitamin D and Adipose Tissue: Implications for Adipogenesis and Adipose Tissue Function
Shiqi Lu, Zhen-Bo Cao
Nutrients.2023; 15(22): 4832. CrossRef
Alanine aminotransferase to high- density lipoprotein cholesterol ratio is positively correlated with the occurrence of diabetes in the Chinese population: a population-based cohort study
Shiming He, Changhui Yu, Maobin Kuang, Jiajun Qiu, Ruijuan Yang, Shuhua Zhang, Guotai Sheng, Yang Zou
Frontiers in Endocrinology.2023;[Epub] CrossRef
The association between the metabolic score for insulin resistance (METS-IR) index and urinary incontinence in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2001–2018
Shangqi Cao, Linghao Meng, Lede Lin, Xu Hu, Xiang Li
Diabetology & Metabolic Syndrome.2023;[Epub] CrossRef
Adipose Tissue, Non-Communicable Diseases, and Physical Exercise: An Imperfect Triangle
Francisco A. Monsalve, Fernando Delgado-López, Barbra Fernández-Tapia, Daniel R. González
International Journal of Molecular Sciences.2023; 24(24): 17168. CrossRef
Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms
Guizheng Wei, Ke Lu, Muhammad Umar, Zhenglin Zhu, William W. Lu, John R. Speakman, Yan Chen, Liping Tong, Di Chen
Bone Research.2023;[Epub] CrossRef
Influence of Sociodemographic Variables and Healthy Habits on the Values of Insulin Resistance Indicators in 386,924 Spanish Workers
Miguel Mestre Font, Carla Busquets-Cortés, José Ignacio Ramírez-Manent, Pilar Tomás-Gil, Hernán Paublini, Ángel Arturo López-González
Nutrients.2023; 15(24): 5122. CrossRef
Konjac flour-mediated gut microbiota alleviates insulin resistance and improves placental angiogenesis of obese sows
Deyuan Wu, Wenyu Xiong, Shuo Ma, Jinxi Luo, Hongxuan Ye, Shuangbo Huang, Fuyong Li, Xi’en Xiang, Qiling Chen, Binghui Gao, Jinping Deng, Yulong Yin, Chengquan Tan
AMB Express.2023;[Epub] CrossRef
Physiological Adaptations to Life in Space: An Update
Isadora de Carvalho e Silva, Thais Russomano, Ricardo Alves Ferreira, Marli do Carmo Cupertino, Fabíola Alves Alcântara, Mauro Geller, Oswaldo Monteiro Del Cima, Rodrigo Siqueira-Batista
Journal of Aerospace Technology and Management.2023;[Epub] CrossRef
Blood and Brain Metabolites after Cerebral Ischemia
Eva Baranovicova, Dagmar Kalenska, Peter Kaplan, Maria Kovalska, Zuzana Tatarkova, Jan Lehotsky
International Journal of Molecular Sciences.2023; 24(24): 17302. CrossRef
Key Therapeutic Targets to Treat Hyperglycemia-Induced Atherosclerosis Analyzed Using a Petri Net-Based Model
Agnieszka Rybarczyk, Dorota Formanowicz, Piotr Formanowicz
Metabolites.2023; 13(12): 1191. CrossRef
Exploration of the Mechanism of the Comorbidity Relationship between Alzheimer’s Disease and Diabetes Mellitus
涛温
Medical Diagnosis.2023; 13(04): 440. CrossRef
Postbiyotikler ve İnsülin Direnci
Betül SARIDAĞ DEVRAN, Mendane SAKA
Van Sağlık Bilimleri Dergisi.2023; 16(3): 268. CrossRef
The Anti-Diabetic Potential of Baicalin: Evidence from Rodent Studies
Tomasz Szkudelski, Katarzyna Szkudelska
International Journal of Molecular Sciences.2023; 25(1): 431. CrossRef
Clinical application of Momordica charantia (Bitter Melon) for reducing blood sugar in type 2 diabetes mellitus
Ashley Dahlquist, Dana Jandali, Mirielle C. Nauman, Jeremy J. Johnson, Sasho Stoleski
International Journal of Nutrition.2023; 7(4): 8. CrossRef
Alkaloids as Promising Agents for the Management of Insulin Resistance: A Review
Ayoub Amssayef, Mohamed Eddouks
Current Pharmaceutical Design.2023; 29(39): 3123. CrossRef
A Brief Review of Commonly Used Indices for the Assessment of Insulin Sensitivity and Resistance
Mudhafar S. Khazaal, Rawaa Hamid Abdulshahed, Alaa Khalid Ali Alabbas
Academic International Journal of Medical Update.2023; 1(2): 01. CrossRef
Potential Mechanisms for How Long-Term Physical Activity May Reduce Insulin Resistance
Sindre Lee-Ødegård, Thomas Olsen, Frode Norheim, Christian Andre Drevon, Kåre Inge Birkeland
Metabolites.2022; 12(3): 208. CrossRef
Pathophysiological Link between Insulin Resistance and Adrenal Incidentalomas
Jordan A. Higgs, Alyssa P. Quinn, Kevin D. Seely, Zeke Richards, Shad P. Mortensen, Cody S. Crandall, Amanda E. Brooks
International Journal of Molecular Sciences.2022; 23(8): 4340. CrossRef
The Dose-Response Effects of Consuming High Fructose Corn Syrup-Sweetened Beverages on Hepatic Lipid Content and Insulin Sensitivity in Young Adults
Desiree M. Sigala, Bettina Hieronimus, Valentina Medici, Vivien Lee, Marinelle V. Nunez, Andrew A. Bremer, Chad L. Cox, Candice A. Price, Yanet Benyam, Yasser Abdelhafez, John P. McGahan, Nancy L. Keim, Michael I. Goran, Giovanni Pacini, Andrea Tura, Clau
Nutrients.2022; 14(8): 1648. CrossRef
Association of β-cell function and cognitive impairment in patients with abnormal glucose metabolism
Mengyi Guo, Jiaokun Jia, Jia Zhang, Mingyue Zhou, Anxin Wang, Shengyun Chen, Xingquan Zhao
BMC Neurology.2022;[Epub] CrossRef
The Role of Insulin Resistance in Fueling NAFLD Pathogenesis: From Molecular Mechanisms to Clinical Implications
Rossella Palma, Annamaria Pronio, Mario Romeo, Flavia Scognamiglio, Lorenzo Ventriglia, Vittorio Maria Ormando, Antonietta Lamazza, Stefano Pontone, Alessandro Federico, Marcello Dallio
Journal of Clinical Medicine.2022; 11(13): 3649. CrossRef
Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction
Kah Kheng Goh, Cynthia Yi-An Chen, Tzu-Hua Wu, Chun-Hsin Chen, Mong-Liang Lu
International Journal of Molecular Sciences.2022; 23(13): 7092. CrossRef
TyG index is positively associated with risk of CHD and coronary atherosclerosis severity among NAFLD patients
Jianqi Zhao, Hongxuan Fan, Ting Wang, Bing Yu, Shaobin Mao, Xun Wang, Wenjing Zhang, Leigang Wang, Yao Zhang, Zhaoyu Ren, Bin Liang
Cardiovascular Diabetology.2022;[Epub] CrossRef
The Association of Acute Phase Proteins in Stress and Inflammation-Induced T2D
Tammy Speelman, Lieke Dale, Ann Louw, Nicolette J. D. Verhoog
Cells.2022; 11(14): 2163. CrossRef
Probiotic Mechanisms Affecting Glucose Homeostasis: A Scoping Review
Maša Pintarič, Tomaž Langerholc
Life.2022; 12(8): 1187. CrossRef
Potential Molecular Targets of Oleanolic Acid in Insulin Resistance and Underlying Oxidative Stress: A Systematic Review
Ángel Fernández-Aparicio, María Correa-Rodríguez, Jose M. Castellano, Jacqueline Schmidt-RioValle, Javier S. Perona, Emilio González-Jiménez
Antioxidants.2022; 11(8): 1517. CrossRef
Impact of Highly Saturated versus Unsaturated Fat Intake on Carbohydrate Metabolism and Vascular Reactivity in Rat
Youzan Ferdinand Djohan, Fabrice Raynaud, Karen Lambert, Jean-Paul Cristol, Charles Coudray, Christine Feillet-Coudray, Anne Virsolvy, Eric Badia, Néstor Gutiérrez-Méndez
Biochemistry Research International.2022; 2022: 1. CrossRef
Mitophagy: A potential therapeutic target for insulin resistance
Peng Ning, Xiaobo Jiang, Jing Yang, Jiaxing Zhang, Fan Yang, Hongyi Cao
Frontiers in Physiology.2022;[Epub] CrossRef
Higher neutrophil to lymphocyte ratio is associated with renal dysfunction and cardiac adverse remodeling in elderly with metabolic syndrome
Yuqi Zhu, Gang Li, Jari A. Laukkanen, Xing Song, Jing Zhang, Linping Wei, Xinrui Chen, Yufeng Li, Cheng Liu
Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef
Lipid droplet accumulation in β cells in patients with type 2 diabetes is associated with insulin resistance, hyperglycemia and β cell dysfunction involving decreased insulin granules
Tomomi Horii, Junji Kozawa, Yukari Fujita, Satoshi Kawata, Harutoshi Ozawa, Chisaki Ishibashi, Sho Yoneda, Takao Nammo, Jun-ichiro Miyagawa, Hidetoshi Eguchi, Iichiro Shimomura
Frontiers in Endocrinology.2022;[Epub] CrossRef
Comparing the long non-coding RNA expression profiles of skeletal muscle and kidney tissues from patients with diabetes
Young-Kook Kim, Takahiro Nemoto
PLOS ONE.2022; 17(9): e0274794. CrossRef
The CCR2+ Monocyte Subsets Increase in Obese Boys but Not Girls with Abnormally High Carotid Intima-Media Thickness: A Pilot Study
María José Garcés-Hernández, Karen Pedraza-Escudero, Nayely Garibay-Nieto, Joselin Hernández-Ruiz, Jessica Lakshmi Prieto-Chávez, Lourdes Andrea Arriaga-Pizano, Eréndira Villanueva-Ortega, Galileo Escobedo, Aaron Noe Manjarrez-Reyna, Juan Carlos López-Alv
Journal of Cardiovascular Development and Disease.2022; 9(10): 330. CrossRef
Effect of honey bee venom on the histological changes of testes and hormonal disturbance in diabetic mice
Sattar J. J. AL-Shaeli, Talal Jabal Hussen, Ali M. Ethaeb
Veterinary World.2022; : 2357. CrossRef
Establishment and Validation of a New Predictive Model for Insulin Resistance based on 2 Chinese Cohorts: A Cross-Sectional Study
Shi Zhang, Xin-Cheng Wang, Jing Li, Xiao-He Wang, Yi Wang, Yan-Ju Zhang, Mei-Yang Du, Min-Ying Zhang, Jing-Na Lin, Chun-Jun Li, Aman Rajpal
International Journal of Endocrinology.2022; 2022: 1. CrossRef
Zishen Pill alleviates diabetes in Db/db mice via activation of PI3K/AKT pathway in the liver
You Wu, Boju Sun, Xiaoyuan Guo, Lili Wu, Yaomu Hu, Lingling Qin, Tao Yang, Mei Li, Tianyu Qin, Miao Jiang, Tonghua Liu
Chinese Medicine.2022;[Epub] CrossRef
Effect of Insulin and Pioglitazone on Protein Phosphatase 2A Interaction Partners in Primary Human Skeletal Muscle Cells Derived from Obese Insulin-Resistant Participants
Lana Alghanem, Xiangmin Zhang, Ruchi Jaiswal, Berhane Seyoum, Abdullah Mallisho, Zaher Msallaty, Zhengping Yi
ACS Omega.2022; 7(47): 42763. CrossRef
Dietary Plant Protein Intake Can Reduce Maternal Insulin Resistance during Pregnancy
Yuting Hong, Chen Yang, Jinjing Zhong, Yanmei Hou, Kui Xie, Linlin Wang
Nutrients.2022; 14(23): 5039. CrossRef
Preventive effect of probiotics supplementation on occurrence of gestational diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials
Azin Pakmehr, Hanieh-Sadat Ejtahed, Nooshin Shirzad, Mahboobeh Hemmatabadi, Sara Farhat, Bagher Larijani
Frontiers in Medicine.2022;[Epub] CrossRef
Insulin resistance in ischemic stroke: Mechanisms and therapeutic approaches
Peng-Fei Ding, Hua-Sheng Zhang, Jie Wang, Yong-Yue Gao, Jian-Nan Mao, Chun-Hua Hang, Wei Li
Frontiers in Endocrinology.2022;[Epub] CrossRef
Long Noncoding RNAs in the Pathogenesis of Insulin Resistance
Weili Yang, Yixiang Lyu, Rui Xiang, Jichun Yang
International Journal of Molecular Sciences.2022; 23(24): 16054. CrossRef
Predictability of HOMA-IR for Gestational Diabetes Mellitus in Early Pregnancy Based on Different First Trimester BMI Values
Yanbei Duo, Shuoning Song, Yuemei Zhang, Xiaolin Qiao, Jiyu Xu, Jing Zhang, Zhenyao Peng, Yan Chen, Xiaorui Nie, Qiujin Sun, Xianchun Yang, Ailing Wang, Wei Sun, Yong Fu, Yingyue Dong, Zechun Lu, Tao Yuan, Weigang Zhao
Journal of Personalized Medicine.2022; 13(1): 60. CrossRef
MODERN CONCEPTS OF THE PATHOGENESIS OF TYPE 2 DIABETES MELLITUS
D.V. Kurkin, E.I. Morkovin, D.A. Bakulin, Yu.V. Gorbunova, A.V. Strygin, A.I. Robertus, I.E. Makarenko, V.B. Saparova, R.V. Drai, V.I. Petrov
Journal of Volgograd State Medical University.2022; 19(4): 34. CrossRef

Islet Studies and Transplantation
Regulation of Pancreatic β-Cell Mass by Gene-Environment Interaction: Shun-ichiro Asahara, Hiroyuki Inoue, Yoshiaki Kido; Diabetes Metab J. 2022;46(1):38-48. Published online January 27, 2022; DOI: https://doi.org/10.4093/dmj.2021.0045

6,217 View
229 Download
9 Web of Science
8 Crossref

Graphical Abstract Abstract PDF PubReader ePub

The main pathogenic mechanism of diabetes consists of an increase in insulin resistance and a decrease in insulin secretion from pancreatic β-cells. The number of diabetic patients has been increasing dramatically worldwide, especially in Asian people whose capacity for insulin secretion is inherently lower than that of other ethnic populations. Causally, changes of environmental factors in addition to intrinsic genetic factors have been considered to have an influence on the increased prevalence of diabetes. Particular focus has been placed on “gene-environment interactions” in the development of a reduced pancreatic β-cell mass, as well as type 1 and type 2 diabetes mellitus. Changes in the intrauterine environment, such as intrauterine growth restriction, contribute to alterations of gene expression in pancreatic β-cells, ultimately resulting in the development of pancreatic β-cell failure and diabetes. As a molecular mechanism underlying the effect of the intrauterine environment, epigenetic modifications have been widely investigated. The association of diabetes susceptibility genes or dietary habits with gene-environment interactions has been reported. In this review, we provide an overview of the role of gene-environment interactions in pancreatic β-cell failure as revealed by previous reports and data from experiments.

Citations

Citations to this article as recorded by

Leptin Rs7799039 polymorphism is associated with type 2 diabetes mellitus Egyptian patients
Amal Ahmed Mohamed, Dina M. Abo-Elmatty, Alaa S. Wahba, Omnia Ezzat Esmail, Hadeer Saied Mahmoud Salim, Wafaa Salah Mohammed Hegab, Mona Mostafa Farid Ghanem, Nadia Youssef Riad, Doaa Ghaith, Lamiaa I Daker, Shorouk Issa, Noha Hassan Radwan, Eman Sultan,
Archives of Physiology and Biochemistry.2024; 130(6): 742. CrossRef
Higher Genetic Risk for Type 2 Diabetes Is Associated With a Faster Decline of β-Cell Function in an East Asian Population
Hyunsuk Lee, Jaewon Choi, Jong-Il Kim, Richard M. Watanabe, Nam H. Cho, Kyong Soo Park, Soo Heon Kwak
Diabetes Care.2024; 47(8): 1386. CrossRef
Protein Arginine Methyltransferases: Emerging Targets in Cardiovascular and Metabolic Disease
Yan Zhang, Shibo Wei, Eun-Ju Jin, Yunju Jo, Chang-Myung Oh, Gyu-Un Bae, Jong-Sun Kang, Dongryeol Ryu
Diabetes & Metabolism Journal.2024; 48(4): 487. CrossRef
Recent Glycemia Is a Major Determinant of β-Cell Function in Type 2 Diabetes Mellitus
Ji Yoon Kim, Jiyoon Lee, Sin Gon Kim, Nam Hoon Kim
Diabetes & Metabolism Journal.2024; 48(6): 1135. CrossRef
Increased risk of incident diabetes after therapy with immune checkpoint inhibitor compared with conventional chemotherapy: A longitudinal trajectory analysis using a tertiary care hospital database
Minyoung Lee, Kyeongseob Jeong, Yu Rang Park, Yumie Rhee
Metabolism.2023; 138: 155311. CrossRef
The ameliorating effects of mesenchymal stem cells compared to α‐tocopherol on apoptosis and autophagy in streptozotocin‐induced diabetic rats: Implication of PI3K/Akt signaling pathway and entero‐insular axis
Heba A. Mubarak, Manal M. Kamal, Yossra Mahmoud, Fatma S. Abd‐Elsamea, Eman Abdelbary, Marwa G. Gamea, Reham I. El‐Mahdy
Journal of Cellular Biochemistry.2023; 124(11): 1705. CrossRef
Association of Polygenic Variants with Type 2 Diabetes Risk and Their Interaction with Lifestyles in Asians
Haeng Jeon Hur, Hye Jeong Yang, Min Jung Kim, Kyun-Hee Lee, Myung-Sunny Kim, Sunmin Park
Nutrients.2022; 14(15): 3222. CrossRef
Chemical Compounds and Ambient Factors Affecting Pancreatic Alpha-Cells Mass and Function: What Evidence?
Gaia Chiara Mannino, Elettra Mancuso, Stefano Sbrignadello, Micaela Morettini, Francesco Andreozzi, Andrea Tura
International Journal of Environmental Research and Public Health.2022; 19(24): 16489. CrossRef

Cardiovascular Risk/Epidemiology
Association between Variability of Metabolic Risk Factors and Cardiometabolic Outcomes: Min Jeong Park, Kyung Mook Choi; Diabetes Metab J. 2022;46(1):49-62. Published online January 27, 2022; DOI: https://doi.org/10.4093/dmj.2021.0316

7,083 View
248 Download
6 Web of Science
11 Crossref

Graphical Abstract Abstract PDF PubReader ePub

Despite strenuous efforts to reduce cardiovascular disease (CVD) risk by improving cardiometabolic risk factors, such as glucose and cholesterol levels, and blood pressure, there is still residual risk even in patients reaching treatment targets. Recently, researchers have begun to focus on the variability of metabolic variables to remove residual risks. Several clinical trials and cohort studies have reported a relationship between the variability of metabolic parameters and CVDs. Herein, we review the literature regarding the effect of metabolic factor variability and CVD risk, and describe possible mechanisms and potential treatment perspectives for reducing cardiometabolic risk factor variability.

Citations

Citations to this article as recorded by

4-week results of “Linni Slim” synbiotic in patients with metabolic syndrome
A. S. Rudoy, N. N. Silivinchik
Experimental and Clinical Gastroenterology.2024; (3): 87. CrossRef
Association between weight loss and cardiovascular outcomes and mortality in Korea: A nationwide cohort study
So Yoon Kwon, Gyuri Kim, Seohyun Kim, Jae Hyeon Kim
Diabetes Research and Clinical Practice.2024; 214: 111767. CrossRef
Identifying Personal and Lifestyle Determinants Associated With Glycemic Variability Among Healthy Non-Diabetes Adults
SuJin Song
CardioMetabolic Syndrome Journal.2024; 4(2): 93. CrossRef
Новий сучасний скринінговий комплекс профілактичної медицини
M.S. Cherska, S.V. Kutsevlyak
Endokrynologia.2024; 29(3): 207. CrossRef
Long-term variability in physiological measures in relation to mortality and epigenetic aging: prospective studies in the USA and China
Hui Chen, Tianjing Zhou, Shaowei Wu, Yaying Cao, Geng Zong, Changzheng Yuan
BMC Medicine.2023;[Epub] CrossRef
Dose–response relationship between physical activity and cardiometabolic risk in obese children and adolescents: A pre-post quasi-experimental study
Zekai Chen, Lin Zhu
Frontiers in Physiology.2023;[Epub] CrossRef
Association of body weight change with all-cause and cause-specific mortality: A nationwide population-based study
So Yoon Kwon, Gyuri Kim, Jungkuk Lee, Jiyun Park, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
Diabetes Research and Clinical Practice.2023; 199: 110666. CrossRef
Association between lipid variability and the risk of mortality in cancer patients not receiving lipid-lowering agents
Seohyun Kim, Gyuri Kim, So Hyun Cho, Rosa Oh, Ji Yoon Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
Frontiers in Oncology.2023;[Epub] CrossRef
Association between visit-to-visit lipid variability and risk of ischemic heart disease: a cohort study in China
Yonghao Wu, Peng Shen, Lisha Xu, Zongming Yang, Yexiang Sun, Luhua Yu, Zhanghang Zhu, Tiezheng Li, Dan Luo, Hongbo Lin, Liming Shui, Mengling Tang, Mingjuan Jin, Kun Chen, Jianbing Wang
Endocrine.2023; 84(3): 914. CrossRef
Variability of Metabolic Risk Factors: Causative Factor or Epiphenomenon?
Hye Jin Yoo
Diabetes & Metabolism Journal.2022; 46(2): 257. CrossRef
Long-Term Variability in Physiological Measures in Relation to Mortality and Epigenetic Aging: Prospective Studies in the US and China
Hui Chen, Tianjing Zhou, Shaowei Wu, Yaying Cao, Geng Zong, Changzheng Yuan
SSRN Electronic Journal .2022;[Epub] CrossRef

Original Articles

Drug/Regimen
Increasing Age Associated with Higher Dipeptidyl Peptidase-4 Inhibition Rate Is a Predictive Factor for Efficacy of Dipeptidyl Peptidase-4 Inhibitors: Sangmo Hong, Chang Hee Jung, Song Han, Cheol-Young Park; Diabetes Metab J. 2022;46(1):63-70. Published online April 19, 2021; DOI: https://doi.org/10.4093/dmj.2020.0253

65,535 View
303 Download
1 Web of Science
2 Crossref

Graphical Abstract Abstract PDF Supplementary Material PubReader ePub

Background
It is not known which type 2 diabetes mellitus (T2DM) patients would most benefit from dipeptidyl peptidase-4 (DPP-4) inhibitor treatment. We aimed to investigate the predictors of response to DPP-4 inhibitors considering degree of DPP-4 inhibition.
Methods
This study is a post hoc analysis of a 24-week, randomized, double-blind, phase III trial that compared the efficacy and safety of a DPP-4 inhibitor (gemigliptin vs. sitagliptin) in patients with T2DM. Subjects were classified into tertiles of T1 <65.26%, T2=65.26%–76.35%, and T3 ≥76.35% by DPP-4 inhibition. We analyzed the change from baseline in glycosylated hemoglobin (HbA1c) according to DPP-4 inhibition with multiple linear regression adjusting for age, ethnicity, body mass index, baseline HbA1c, and DPP-4 activity at baseline.
Results
The mean age was greater in the high tertile group compared with the low tertile group (T1: 49.8±8.3 vs. T2: 53.1±10.5 vs. T3: 55.3±9.5, P<0.001) of DPP-4 inhibition. Although HbA1c at baseline was not different among tertiles of DPP-4 inhibition (P=0.398), HbA1c after 24-week treatment was lower in the higher tertile compares to the lower tertile (T1: 7.30%±0.88% vs. T2: 7.12%±0.78% vs. T3: 7.00%±0.78%, P=0.021). In multiple regression analysis, DPP-4 enzyme inhibition rate was not a significant determent for HbA1c reduction due to age. In subgroup analysis by tertile of DPP-4 inhibition, age was the only significant predictor and only in the highest tertile (R²=0.281, B=–0.014, P=0.024).
Conclusion
This study showed that HbA1c reduction by DPP-4 inhibitor was associated with increasing age, and this association was linked with higher DPP-4 inhibition.

Citations

Citations to this article as recorded by

Comparative efficacy and safety of sitagliptin or gliclazide combined with metformin in treatment-naive patients with type 2 diabetes: A single-center, prospective, randomized, controlled, noninferiority study with genetic polymorphism analysis
Min Qin, Lingxi Chao, Shiqun Liu
Medicine.2025; 104(2): e41061. CrossRef
Neurological Sequelae of Post-COVID-19 Fatigue: A Narrative Review of Dipeptidyl Peptidase IV-Mediated Cerebrovascular Complications
Che Mohd Nasril Che Mohd Nassir, Muhammad Danial Che Ramli, Usman Jaffer, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Mazira Mohamad Ghazali, Ebrahim Nangarath Kottakal Cheriya
Current Issues in Molecular Biology.2024; 46(12): 13565. CrossRef

Drug/Regimen
Efficacy and Safety of Self-Titration Algorithms of Insulin Glargine 300 units/mL in Individuals with Uncontrolled Type 2 Diabetes Mellitus (The Korean TITRATION Study): A Randomized Controlled Trial: Jae Hyun Bae, Chang Ho Ahn, Ye Seul Yang, Sun Joon Moon, Soo Heon Kwak, Hye Seung Jung, Kyong Soo Park, Young Min Cho; Diabetes Metab J. 2022;46(1):71-80. Published online June 16, 2021; DOI: https://doi.org/10.4093/dmj.2020.0274

11,000 View
477 Download
2 Web of Science
4 Crossref

Graphical Abstract Abstract PDF Supplementary Material PubReader ePub

Background
To compare the efficacy and safety of two insulin self-titration algorithms, Implementing New Strategies with Insulin Glargine for Hyperglycemia Treatment (INSIGHT) and EDITION, for insulin glargine 300 units/mL (Gla-300) in Korean individuals with uncontrolled type 2 diabetes mellitus (T2DM).
Methods
In a 12-week, randomized, open-label trial, individuals with uncontrolled T2DM requiring basal insulin were randomized to either the INSIGHT (adjusted by 1 unit/day) or EDITION (adjusted by 3 units/week) algorithm to achieve a fasting self-monitoring of blood glucose (SMBG) in the range of 4.4 to 5.6 mmol/L. The primary outcome was the proportion of individuals achieving a fasting SMBG ≤5.6 mmol/L without noct urnal hypoglycemia at week 12.
Results
Of 129 individuals (age, 64.1±9.5 years; 66 [51.2%] women), 65 and 64 were randomized to the INSIGHT and EDITION algorithms, respectively. The primary outcome of achievement was comparable between the two groups (24.6% vs. 23.4%, P=0.876). Compared with the EDITION group, the INSIGHT group had a greater reduction in 7-point SMBG but a similar decrease in fasting plasma glucose and glycosylated hemoglobin. The increment of total daily insulin dose was significantly higher in the INSIGHT group than in the EDITION group (between-group difference: 5.8±2.7 units/day, P=0.033). However, body weight was significantly increased only in the EDITION group (0.6±2.4 kg, P=0.038). There was no difference in the occurrence of hypoglycemia between the two groups. Patient satisfaction was significantly increased in the INSIGHT group (P=0.014).
Conclusion
The self-titration of Gla-300 using the INSIGHT algorithm was effective and safe compared with that using the EDITION algorithm in Korean individuals with uncontrolled T2DM (ClinicalTrials.gov number: NCT03406663).

Citations

Citations to this article as recorded by

Time for Using Machine Learning for Dose Guidance in Titration of People With Type 2 Diabetes? A Systematic Review of Basal Insulin Dose Guidance
Camilla Heisel Nyholm Thomsen, Stine Hangaard, Thomas Kronborg, Peter Vestergaard, Ole Hejlesen, Morten Hasselstrøm Jensen
Journal of Diabetes Science and Technology.2024; 18(5): 1185. CrossRef
Comparative efficacy and safety of weekly tirzepatide versus weekly insulin in type 2 diabetes: A network meta‐analysis of randomized clinical trials
Hazem Ayesh, Sajida Suhail, Suhail Ayesh, Kevin Niswender
Diabetes, Obesity and Metabolism.2024; 26(9): 3801. CrossRef
Basal insulin titration algorithms in patients with type 2 diabetes: the simplest is the best (?)
V.I. Katerenchuk
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2023; 19(1): 72. CrossRef
Issues of insulin therapy for type 2 diabetes and ways to solve them
V.I. Katerenchuk, A.V. Katerenchuk
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2023; 19(3): 240. CrossRef

Drug/Regimen
Effects of Teneligliptin on HbA1c levels, Continuous Glucose Monitoring-Derived Time in Range and Glycemic Variability in Elderly Patients with T2DM (TEDDY Study): Ji Cheol Bae, Soo Heon Kwak, Hyun Jin Kim, Sang-Yong Kim, You-Cheol Hwang, Sunghwan Suh, Bok Jin Hyun, Ji Eun Cha, Jong Chul Won, Jae Hyeon Kim; Diabetes Metab J. 2022;46(1):81-92. Published online June 16, 2021; DOI: https://doi.org/10.4093/dmj.2021.0016

9,368 View
465 Download
5 Web of Science
5 Crossref

Graphical Abstract Abstract PDF Supplementary Material PubReader ePub

Background
To evaluate the effects of teneligliptin on glycosylated hemoglobin (HbA1c) levels, continuous glucose monitoring (CGM)-derived time in range, and glycemic variability in elderly type 2 diabetes mellitus patients.
Methods
This randomized, double-blinded, placebo-controlled study was conducted in eight centers in Korea (clinical trial registration number: NCT03508323). Sixty-five participants aged ≥65 years, who were treatment-naïve or had been treated with stable doses of metformin, were randomized at a 1:1 ratio to receive 20 mg of teneligliptin (n=35) or placebo (n=30) for 12 weeks. The main endpoints were the changes in HbA1c levels from baseline to week 12, CGM metrics-derived time in range, and glycemic variability.
Results
After 12 weeks, a significant reduction (by 0.84%) in HbA1c levels was observed in the teneligliptin group compared to that in the placebo group (by 0.08%), with a between-group least squares mean difference of –0.76% (95% confidence interval [CI], –1.08 to –0.44). The coefficient of variation, standard deviation, and mean amplitude of glycemic excursion significantly decreased in participants treated with teneligliptin as compared to those in the placebo group. Teneligliptin treatment significantly decreased the time spent above 180 or 250 mg/dL, respectively, without increasing the time spent below 70 mg/dL. The mean percentage of time for which glucose levels remained in the 70 to 180 mg/dL time in range (TIR70–180) at week 12 was 82.0%±16.0% in the teneligliptin group, and placebo-adjusted change in TIR70–180 from baseline was 13.3% (95% CI, 6.0 to 20.6).
Conclusion
Teneligliptin effectively reduced HbA1c levels, time spent above the target range, and glycemic variability, without increasing hypoglycemia in our study population.

Citations

Citations to this article as recorded by

Comparison of teneligliptin and other gliptin-based regimens in addressing insulin resistance and glycemic control in type 2 diabetic patients: a cross-sectional study
Harmanjit Singh, Ravi Rohilla, Shivani Jaswal, Mandeep Singla
Expert Review of Endocrinology & Metabolism.2024; 19(1): 81. CrossRef
Potential approaches using teneligliptin for the treatment of type 2 diabetes mellitus: current status and future prospects
Harmanjit Singh, Jasbir Singh, Ravneet Kaur Bhangu, Mandeep Singla, Jagjit Singh, Farideh Javid
Expert Review of Clinical Pharmacology.2023; 16(1): 49. CrossRef
Mechanism of molecular interaction of sitagliptin with human DPP4 enzyme - New Insights
Michelangelo Bauwelz Gonzatti, José Edvar Monteiro Júnior, Antônio José Rocha, Jonathas Sales de Oliveira, Antônio José de Jesus Evangelista, Fátima Morgana Pio Fonseca, Vânia Marilande Ceccatto, Ariclécio Cunha de Oliveira, José Ednésio da Cruz Freire
Advances in Medical Sciences.2023; 68(2): 402. CrossRef
A prospective multicentre open label study to assess effect of Teneligliptin on glycemic control through parameters of time in range (TIR) Metric using continuous glucose monitoring (TOP-TIR study)
Banshi Saboo, Suhas Erande, A.G. Unnikrishnan
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2022; 16(2): 102394. CrossRef
Association between Variability of Metabolic Risk Factors and Cardiometabolic Outcomes
Min Jeong Park, Kyung Mook Choi
Diabetes & Metabolism Journal.2022; 46(1): 49. CrossRef

Type 1 Diabetes
Association between Metabolic Syndrome and Microvascular Complications in Chinese Adults with Type 1 Diabetes Mellitus: Qianwen Huang, Daizhi Yang, Hongrong Deng, Hua Liang, Xueying Zheng, Jinhua Yan, Wen Xu, Xiangwen Liu, Bin Yao, Sihui Luo, Jianping Weng; Diabetes Metab J. 2022;46(1):93-103. Published online August 31, 2021; DOI: https://doi.org/10.4093/dmj.2020.0240

7,529 View
234 Download
8 Web of Science
9 Crossref

Graphical Abstract Abstract PDF Supplementary Material PubReader ePub

Background
Both type 1 diabetes mellitus (T1DM) and metabolic syndrome (MetS) are associated with an elevated risk of morbidity and mortality yet with increasing heterogeneity. This study primarily aimed to evaluate the prevalence of MetS among adult patients with T1DM in China and investigate its associated risk factors, and relationship with microvascular complications.
Methods
We included adult patients who had been enrolled in the Guangdong T1DM Translational Medicine Study conducted from June 2010 to June 2015. MetS was defined according to the updated National Cholesterol Education Program criterion. Logistic regression models were used to estimate the odds ratio (OR) for the association between MetS and the risk of diabetic kidney disease (DKD) and diabetic retinopathy (DR).
Results
Among the 569 eligible patients enrolled, the prevalence of MetS was 15.1%. While female gender, longer diabetes duration, higher body mass index, and glycosylated hemoglobin A1c (HbA1c) were risk factors associated with MetS (OR, 2.86, 1.04, 1.14, and 1.23, respectively), received nutrition therapy education was a protective factor (OR, 0.46). After adjustment for gender, age, diabetes duration, HbA1c, socioeconomic and lifestyle variables, MetS status was associated with an increased risk of DKD and DR (OR, 2.14 and 3.72, respectively; both P<0.05).
Conclusion
Although the prevalence of MetS in adult patients with T1DM in China was relatively low, patients with MetS were more likely to have DKD and DR. A comprehensive management including lifestyle modification might reduce their risk of microvascular complications in adults with T1DM.

Citations

Citations to this article as recorded by

Dynamic Changes in Metabolic Status Are Associated With Risk of Ocular Motor Cranial Nerve Palsies
Daye Diana Choi, Kyung-Ah Park, Kyungdo Han, Sei Yeul Oh
Journal of Neuro-Ophthalmology.2024; 44(3): 386. CrossRef
Prevalence of Metabolic Syndrome and Its Risk Factors Influence on Microvascular Complications in Patients With Type 1 and Type 2 Diabetes Mellitus
Asad Riaz, Shoaib Asghar, Salman Shahid, Haider Tanvir, Muhammad Hamza Ejaz, Mamuna Akram
Cureus.2024;[Epub] CrossRef
Simplified integration of optimal self-management behaviors is associated with improved HbA1c in patients with type 1 diabetes
C. Deng, Y. Xie, F. Liu, X. Tang, L. Fan, X. Yang, Y. Chen, Z. Zhou, X. Li
Journal of Endocrinological Investigation.2024; 47(11): 2691. CrossRef
Correlation between triglyceride-glucose index and diabetic kidney disease risk in adults with type 1 diabetes mellitus
Mengyun Lei, Ping Ling, Yongwen Zhou, Jing Lv, Ying Ni, Hongrong Deng, Chaofan Wang, Daizhi Yang, Xubin Yang, Wen Xu, Jinhua Yan
Diabetology & Metabolic Syndrome.2024;[Epub] CrossRef
Development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the Chinese adults
Shujuan Yang, Bin Yu, Wanqi Yu, Shaoqing Dai, Chuanteng Feng, Ying Shao, Xing Zhao, Xiaoqing Li, Tianjing He, Peng Jia
Nature Communications.2023;[Epub] CrossRef
Association of Endotoxemia with Low-Grade Inflammation, Metabolic Syndrome and Distinct Response to Lipopolysaccharide in Type 1 Diabetes
Aleksejs Fedulovs, Leonora Pahirko, Kaspars Jekabsons, Liga Kunrade, Jānis Valeinis, Una Riekstina, Valdis Pīrāgs, Jelizaveta Sokolovska
Biomedicines.2023; 11(12): 3269. CrossRef
Association between Metabolic Syndrome and Microvascular Complications in Chinese Adults with Type 1 Diabetes Mellitus (Diabetes Metab J 2022;46:93-103)
Qianwen Huang, Sihui Luo
Diabetes & Metabolism Journal.2022; 46(3): 515. CrossRef
Association between Metabolic Syndrome and Microvascular Complications in Chinese Adults with Type 1 Diabetes Mellitus (Diabetes Metab J 2022;46:93-103)
Gyuri Kim
Diabetes & Metabolism Journal.2022; 46(3): 512. CrossRef
Metabolic syndrome associated with higher glycemic variability in type 1 diabetes: A multicenter cross-sectional study in china
Keyu Guo, Liyin Zhang, Jianan Ye, Xiaohong Niu, Hongwei Jiang, Shenglian Gan, Jian Zhou, Lin Yang, Zhiguang Zhou
Frontiers in Endocrinology.2022;[Epub] CrossRef

Complications
Renal Tubular Damage Marker, Urinary N-acetyl-β-D-Glucosaminidase, as a Predictive Marker of Hepatic Fibrosis in Type 2 Diabetes Mellitus: Hae Kyung Kim, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee; Diabetes Metab J. 2022;46(1):104-116. Published online July 13, 2021; DOI: https://doi.org/10.4093/dmj.2020.0273

7,377 View
217 Download
5 Web of Science
6 Crossref

Graphical Abstract Abstract PDF Supplementary Material PubReader ePub

Background
Non-alcoholic steatohepatitis is closely associated with the progression of diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM). We investigated whether urinary N-acetyl-β-D-glucosaminidase (u-NAG), an early renal tubular damage biomarker in DKD, could be related to the degree of hepatic fibrosis in patients with T2DM.
Methods
A total of 300 patients with T2DM were enrolled in this study. Hepatic steatosis and fibrosis were determined using transient elastography. The levels of urinary biomarkers, including u-NAG, albumin, protein, and creatinine, and glucometabolic parameters were measured.
Results
Based on the median value of the u-NAG to creatinine ratio (u-NCR), subjects were divided into low and high u-NCR groups. The high u-NCR group showed a significantly longer duration of diabetes, worsened hyperglycemia, and a more enhanced hepatic fibrosis index. A higher u-NCR was associated with a greater odds ratio for the risk of higher hepatic fibrosis stage (F2: odds ratio, 1.99; 95% confidence interval [CI], 1.04 to 3.82). Also, u-NCR was an independent predictive marker for more advanced hepatic fibrosis, even after adjusting for several confounding factors (β=1.58, P<0.01).
Conclusion
The elevation of u-NAG was independently associated with a higher degree of hepatic fibrosis in patients with T2DM. Considering the common metabolic milieu of renal and hepatic fibrosis in T2DM, the potential use of u-NAG as an effective urinary biomarker reflecting hepatic fibrosis in T2DM needs to be validated in the future.

Citations

Citations to this article as recorded by

Changes in urinary renal injury markers in children with Mycoplasma pneumoniae pneumonia and a prediction model for related early renal injury
Ju Zhang, He-kai Ma, Bao-wen Li, Ke-Ke Ma, Yu-Ling Zhang, Shu-jun Li
Italian Journal of Pediatrics.2024;[Epub] CrossRef
Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: a randomized controlled trial
Xiao Tong Teong, Kai Liu, Andrew D. Vincent, Julien Bensalem, Bo Liu, Kathryn J. Hattersley, Lijun Zhao, Christine Feinle-Bisset, Timothy J. Sargeant, Gary A. Wittert, Amy T. Hutchison, Leonie K. Heilbronn
Nature Medicine.2023; 29(4): 963. CrossRef
Significance of Diabetic Kidney Disease Biomarkers in Predicting Metabolic-Associated Fatty Liver Disease
Jaehyun Bae, Byung-Wan Lee
Biomedicines.2023; 11(7): 1928. CrossRef
Abdominal adipose tissue and type 2 diabetic kidney disease: adipose radiology assessment, impact, and mechanisms
Fei Lu, Jinlei Fan, Fangxuan Li, Lijing Liu, Zhiyu Chen, Ziyu Tian, Liping Zuo, Dexin Yu
Abdominal Radiology.2023; 49(2): 560. CrossRef
β‐Amyrin ameliorates diabetic nephropathy in mice and regulates the miR‐181b‐5p/HMGB2 axis in high glucose‐stimulated HK‐2 cells
Wenhua Xu, Hongwu Zhang, Qinfeng Zhang, Jialan Xu
Environmental Toxicology.2022; 37(3): 637. CrossRef
High Glycated Hemoglobin Instead of High Body Mass Index Might Increase the Urine N-Acetyl-β-D-glucosaminidase Con-Centration in Children and Adolescents with Diabetes Mellitus
Jin-Soon Suh, Kyoung Soon Cho, Seul Ki Kim, Shin-Hee Kim, Won Kyoung Cho, Min Ho Jung, Moon Bae Ahn
Life.2022; 12(6): 879. CrossRef

Complications
Influence of Glucose Fluctuation on Peripheral Nerve Damage in Streptozotocin-Induced Diabetic Rats: Yu Ji Kim, Na Young Lee, Kyung Ae Lee, Tae Sun Park, Heung Yong Jin; Diabetes Metab J. 2022;46(1):117-128. Published online September 9, 2021; DOI: https://doi.org/10.4093/dmj.2020.0275

6,698 View
197 Download
5 Web of Science
4 Crossref

Graphical Abstract Abstract PDF PubReader ePub

Background
It is unclear whether glycemic variability (GV) is a risk factor for diabetic peripheral neuropathy (DPN), and whether control of GV is beneficial for DPN. The purpose of this study was to investigate the effect of GV on peripheral nerve damage by inducing glucose fluctuation in streptozotocin-induced diabetic rats.
Methods
Rats were divided into four groups: normal (normal glucose group [NOR]), diabetes without treatment (sustained severe hyperglycemia group; diabetes mellitus [DM]), diabetes+once daily insulin glargine (stable hyperglycemia group; DM+LAN), and diabetes+once daily insulin glargine with twice daily insulin glulisine (unstable glucose fluctuation group; DM+Lantus [LAN]+Apidra [API]). We measured anti-oxidant enzyme levels and behavioral responses against tactile, thermal, and pressure stimuli in the plasma of rats. We also performed a quantitative comparison of cutaneous and sciatic nerves according to glucose fluctuation.
Results
At week 24, intraepidermal nerve fiber density was less reduced in the insulin-administered groups compared to the DM group (P<0.05); however, a significant difference was not observed between the DM+LAN and DM+LAN+API groups irrespective of glucose fluctuation (P>0.05; 16.2±1.6, 12.4±2.0, 14.3±0.9, and 13.9±0.6 for NOR, DM, DM+LAN, and DM+LAN+API, respectively). The DM group exhibited significantly decreased glutathione levels compared to the insulin-administered groups (2.64±0.10 μmol/mL, DM+LAN; 1.93±0.0 μmol/mL, DM+LAN+API vs. 1.25±0.04 μmol/mL, DM; P<0.05).
Conclusion
Our study suggests that glucose control itself is more important than glucose fluctuation in the prevention of peripheral nerve damage, and intra-day glucose fluctuation has a limited effect on the progression of peripheral neuropathy in rats with diabetes.

Citations

Citations to this article as recorded by

Glucose Fluctuation Inhibits Nrf2 Signaling Pathway in Hippocampal Tissues and Exacerbates Cognitive Impairment in Streptozotocin-Induced Diabetic Rats
Haiyan Chi, Yujing Sun, Peng Lin, Junyu Zhou, Jinbiao Zhang, Yachao Yang, Yun Qiao, Deshan Liu, Eusebio Chiefari
Journal of Diabetes Research.2024; 2024: 1. CrossRef
Artesunate Inhibits Apoptosis and Promotes Survival in Schwann Cells via the PI3K/AKT/mTOR Axis in Diabetic Peripheral Neuropathy
Xin Zhang, Zhifang Liang, Ying Zhou, Fang Wang, Shan Wei, Bing Tan, Yujie Guo
Biological and Pharmaceutical Bulletin.2023; 46(6): 764. CrossRef
The Potential of Glucose Treatment to Reduce Reactive Oxygen Species Production and Apoptosis of Inflamed Neural Cells In Vitro
Juin-Hong Cherng, Shu-Jen Chang, Hsin-Da Tsai, Chung-Fang Chun, Gang-Yi Fan, Kenneth Dean Reeves, King Hei Stanley Lam, Yung-Tsan Wu
Biomedicines.2023; 11(7): 1837. CrossRef
Relationship between acute glucose variability and cognitive decline in type 2 diabetes: A systematic review and meta-analysis
Haiyan Chi, Min Song, Jinbiao Zhang, Junyu Zhou, Deshan Liu, Victor Manuel Mendoza-Nuñez
PLOS ONE.2023; 18(9): e0289782. CrossRef

Metabolic Risk/Epidemiology
Serum Retinol-Binding Protein Levels Are Associated with Nonalcoholic Fatty Liver Disease in Chinese Patients with Type 2 Diabetes Mellitus: A Real-World Study: Zhi-Hui Zhang, Jiang-Feng Ke, Jun-Xi Lu, Yun Liu, Ai-Ping Wang, Lian-Xi Li; Diabetes Metab J. 2022;46(1):129-139. Published online August 10, 2021; DOI: https://doi.org/10.4093/dmj.2020.0222

8,493 View
202 Download
11 Web of Science
11 Crossref

Graphical Abstract Abstract PDF PubReader ePub

Background
The association of serum retinol-binding protein (RBP) levels with nonalcoholic fatty liver disease (NAFLD) remains controversial. Furthermore, few studies have investigated their relationship in type 2 diabetes mellitus (T2DM) patients. Therefore, the aim of the present study was to explore the association between serum RBP levels and NAFLD in Chinese inpatients with T2DM.
Methods
This cross-sectional, real-world study included 2,263 Chinese T2DM inpatients. NAFLD was diagnosed by abdominal ultrasonography. The subjects were divided into four groups based on RBP quartiles, and clinical characteristics were compared among the four groups. The associations of both RBP levels and quartiles with the presence of NAFLD were also analyzed.
Results
After adjustment for sex, age, and diabetes duration, there was a significant increase in the prevalence of NAFLD from the lowest to the highest RBP quartiles (30.4%, 40.0%, 42.4%, and 44.7% for the first, second, third, and fourth quartiles, respectively, P<0.001 for trend). Fully adjusted multiple logistic regression analysis revealed that both increased RBP levels (odds ratio, 1.155; 95% confidence interval, 1.012 to 1.318; P=0.033) and quartiles (P=0.014 for trend) were independently associated with the presence of NAFLD in T2DM patients.
Conclusion
Increased serum RBP levels were independently associated with the presence of NAFLD in Chinese T2DM inpatients. Serum RBP levels may be used as one of the indicators to assess the risk of NAFLD in T2DM patients.

Citations

Citations to this article as recorded by

A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system
Julio Aleman, Ravikumar K, Connor Wiegand, Mark E. Schurdak, Lawrence Vernetti, Dillon Gavlock, Celeste Reese, Richard DeBiasio, Greg LaRocca, Yulder Daniel Angarita, Albert Gough, Alejandro Soto-Gutierrez, Jaideep Behari, Vijay K. Yechoor, Mark T. Miedel
Communications Biology.2024;[Epub] CrossRef
Serum Magnesium Levels Are Negatively Associated with Obesity and Abdominal Obesity in Type 2 Diabetes Mellitus: A Real-World Study
Man-Rong Xu, Ai-Ping Wang, Yu-Jie Wang, Jun-Xi Lu, Li Shen, Lian-Xi Li
Diabetes & Metabolism Journal.2024; 48(6): 1147. CrossRef
The relationship between NAFLD and retinol-binding protein 4 - an updated systematic review and meta-analysis
Rui Hu, Xiaoyue Yang, Xiaoyu He, Guangyao Song
Lipids in Health and Disease.2023;[Epub] CrossRef
Blood lactate levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease in type 2 diabetes: a real-world study
Yi-Lin Ma, Jiang-Feng Ke, Jun-Wei Wang, Yu-Jie Wang, Man-Rong Xu, Lian-Xi Li
Frontiers in Endocrinology.2023;[Epub] CrossRef
High‐normal unconjugated bilirubin is associated with decreased risk of chronic kidney disease in type 2 diabetes: A real‐world study
Man‐Rong Xu, Chun‐Hua Jin, Jun‐Xi Lu, Mei‐Fang Li, Lian‐Xi Li
Diabetes/Metabolism Research and Reviews.2023;[Epub] CrossRef
Global prevalence of non-alcoholic fatty liver disease in type 2 diabetes mellitus: an updated systematic review and meta-analysis
Elina En Li Cho, Chong Zhe Ang, Jingxuan Quek, Clarissa Elysia Fu, Lincoln Kai En Lim, Zane En Qi Heng, Darren Jun Hao Tan, Wen Hui Lim, Jie Ning Yong, Rebecca Zeng, Douglas Chee, Benjamin Nah, Cosmas Rinaldi Adithya Lesmana, Aung Hlaing Bwa, Khin Maung W
Gut.2023; 72(11): 2138. CrossRef
Serum iron is closely associated with metabolic dysfunction-associated fatty liver disease in type 2 diabetes: A real-world study
Jun-Wei Wang, Chun-Hua Jin, Jiang-Feng Ke, Yi-Lin Ma, Yu-Jie Wang, Jun-Xi Lu, Mei-Fang Li, Lian-Xi Li
Frontiers in Endocrinology.2022;[Epub] CrossRef
Low-normal serum unconjugated bilirubin levels are associated with late but not early carotid atherosclerotic lesions in T2DM subjects
Chun-Hua Jin, Jun-Wei Wang, Jiang-Feng Ke, Jing-Bo Li, Mei-Fang Li, Lian-Xi Li
Frontiers in Endocrinology.2022;[Epub] CrossRef
Waist-to-height ratio is a simple and practical alternative to waist circumference to diagnose metabolic syndrome in type 2 diabetes
Yi-Lin Ma, Chun-Hua Jin, Cui-Chun Zhao, Jiang-Feng Ke, Jun-Wei Wang, Yu-Jie Wang, Jun-Xi Lu, Gao-Zhong Huang, Lian-Xi Li
Frontiers in Nutrition.2022;[Epub] CrossRef
GA/HbA1c ratio is a simple and practical indicator to evaluate the risk of metabolic dysfunction-associated fatty liver disease in type 2 diabetes: an observational study
Jun-Wei Wang, Chun-Hua Jin, Jiang-Feng Ke, Yi-Lin Ma, Yu-Jie Wang, Jun-Xi Lu, Mei-Fang Li, Lian-Xi Li
Diabetology & Metabolic Syndrome.2022;[Epub] CrossRef
Decreased Serum Osteocalcin is an Independent Risk Factor for Metabolic Dysfunction-Associated Fatty Liver Disease in Type 2 Diabetes
Yu-Jie Wang, Chun-Hua Jin, Jiang-Feng Ke, Jun-Wei Wang, Yi-Lin Ma, Jun-Xi Lu, Mei-Fang Li, Lian-Xi Li
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 3717. CrossRef

Metabolic Risk/Epidemiology
Postprandial Free Fatty Acids at Mid-Pregnancy Increase the Risk of Large-for-Gestational-Age Newborns in Women with Gestational Diabetes Mellitus: So-Yeon Kim, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyung-Soo Kim; Diabetes Metab J. 2022;46(1):140-148. Published online August 9, 2021; DOI: https://doi.org/10.4093/dmj.2021.0023

6,249 View
176 Download
4 Web of Science
4 Crossref

Graphical Abstract Abstract PDF Supplementary Material PubReader ePub

Background
To investigate the association between free fatty acid (FFA) level at mid-pregnancy and large-for-gestational-age (LGA) newborns in women with gestational diabetes mellitus (GDM).
Methods
We enrolled 710 pregnant women diagnosed with GDM from February 2009 to October 2016. GDM was diagnosed by a ‘two-step’ approach with Carpenter and Coustan criteria. We measured plasma lipid profiles including fasting and 2-hour postprandial FFA (2h-FFA) levels at mid-pregnancy. LGA was defined if birthweights of newborns were above the 90th percentile for their gestational age.
Results
Mean age of pregnant women in this study was 33.1 years. Mean pre-pregnancy body mass index (BMI) was 22.4 kg/m². The prevalence of LGA was 8.3% (n=59). Levels of 2h-FFA were higher in women who delivered LGA newborns than in those who delivered non-LGA newborns (416.7 μEq/L vs. 352.5 μEq/L, P=0.006). However, fasting FFA was not significantly different between the two groups. The prevalence of delivering LGA newborns was increased with increasing tertile of 2h-FFA (T1, 4.3%; T2, 9.8%; T3, 10.7%; P for trend <0.05). After adjustment for maternal age, pre-pregnancy BMI, and fasting plasma glucose, the highest tertile of 2h-FFA was 2.38 times (95% confidence interval, 1.11 to 5.13) more likely to have LGA newborns than the lowest tertile. However, there was no significant difference between groups according to fasting FFA tertiles.
Conclusion
In women with GDM, a high 2h-FFA level (but not fasting FFA) at mid-pregnancy is associated with an increasing risk of delivering LGA newborns.

Citations

Citations to this article as recorded by

Advances in free fatty acid profiles in gestational diabetes mellitus
Haoyi Du, Danyang Li, Laura Monjowa Molive, Na Wu
Journal of Translational Medicine.2024;[Epub] CrossRef
Association between serum free fatty acids and gestational diabetes mellitus
Danyang Li, Haoyi Du, Na Wu
Frontiers in Endocrinology.2024;[Epub] CrossRef
Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids
Aijun Tong, Weihao Wu, Zhengxin Chen, Jiahui Wen, Ruibo Jia, Bin Liu, Hui Cao, Chao Zhao
Current Research in Food Science.2023; 6: 100427. CrossRef
Fetal Abdominal Obesity Detected at 24 to 28 Weeks of Gestation Persists until Delivery Despite Management of Gestational Diabetes Mellitus (Diabetes Metab J 2021;45:547-57)
Wonjin Kim, Soo Kyung Park, Yoo Lee Kim
Diabetes & Metabolism Journal.2021; 45(6): 970. CrossRef

Short Communication

Type 1 Diabetes
Real-World Analysis of Therapeutic Outcome in Type 1 Diabetes Mellitus at a Tertiary Care Center: Antonia Kietaibl, Michaela Riedl, Latife Bozkurt; Diabetes Metab J. 2022;46(1):149-153. Published online July 6, 2021; DOI: https://doi.org/10.4093/dmj.2020.0267

5,234 View
159 Download

Abstract PDF PubReader ePub: Insulin replacement in type 1 diabetes mellitus (T1DM) needs intensified treatment, which can either be performed by multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII). This retrospective analysis of a real-world scenario aimed to evaluate whether glycaemic and cardiovascular risk factors could be controlled with CSII outclass MDI as suggested by recent evidence. Data from patients with either insulin pump (n=68) or injection (n=224) therapy at an Austrian tertiary care centre were analysed between January 2016 and December 2017. There were no significant differences with regard to the latest glycosylated hemoglobin, cardiovascular risk factor control or diabetes-associated late complications. Hypoglycaemia was less frequent (P<0.001), sensor-augmented therapy was more common (P=0.003) and mean body mass index (BMI) was higher (P=0.002) with CSII treatment. This retrospective analysis of real-world data in T1DM did not demonstrate the superiority of insulin pump treatment with regard to glycaemic control or cardiovascular risk factor control.

Brief Report

Technology/Device
Do-It-Yourself Open Artificial Pancreas System in Children and Adolescents with Type 1 Diabetes Mellitus: Real-World Data: Min Sun Choi, Seunghyun Lee, Jiwon Kim, Gyuri Kim, Sung Min Park, Jae Hyeon Kim; Diabetes Metab J. 2022;46(1):154-159. Published online November 23, 2021; DOI: https://doi.org/10.4093/dmj.2021.0011

6,532 View
215 Download
6 Web of Science
6 Crossref

Abstract PDF Supplementary Material PubReader ePub

Few studies have been conducted among Asian children and adolescents with type 1 diabetes mellitus (T1DM) using do-it-yourself artificial pancreas system (DIY-APS). We evaluated real-world data of pediatric T1DM patients using DIY-APS. Data were obtained for 10 patients using a DIY-APS with algorithms. We collected sensor glucose and insulin delivery data from each participant for a period of 4 weeks. Average glycosylated hemoglobin was 6.2%±0.3%. The mean percentage of time that glucose level remained in the target range of 70 to 180 mg/dL was 82.4%±7.8%. Other parameters including time above range, time below range and mean glucose were also within the recommended level, similar to previous commercial and DIY-APS studies. However, despite meeting the target range, unadjusted gaps were still observed between the median basal setting and temporary basal insulin, which should be handled by healthcare providers.

Citations

Citations to this article as recorded by

Real-world efficacy and safety of open-source automated insulin delivery for people with type 1 diabetes mellitus: Experience from mainland China
Yongwen Zhou, Mengyun Lei, Daizhi Yang, Ping Ling, Ying Ni, Hongrong Deng, Wen Xu, Xubin Yang, Benjamin John Wheeler, Jianping Weng, Jinhua Yan
Diabetes Research and Clinical Practice.2024; 218: 111910. CrossRef
Advances in Continuous Glucose Monitoring and Integrated Devices for Management of Diabetes with Insulin-Based Therapy: Improvement in Glycemic Control
Jee Hee Yoo, Jae Hyeon Kim
Diabetes & Metabolism Journal.2023; 47(1): 27. CrossRef
Open-source automated insulin delivery systems (OS-AIDs) in a pediatric population with type 1 diabetes in a real-life setting: the AWeSoMe study group experience
Judith Nir, Marianna Rachmiel, Abigail Fraser, Yael Lebenthal, Avivit Brener, Orit Pinhas-Hamiel, Alon Haim, Eve Stern, Noa Levek, Tal Ben-Ari, Zohar Landau
Endocrine.2023; 81(2): 262. CrossRef
Efficacy and safety of Android artificial pancreas system use at home among adults with type 1 diabetes mellitus in China: protocol of a 26-week, free-living, randomised, open-label, two-arm, two-phase, crossover trial
Mengyun Lei, Beisi Lin, Ping Ling, Zhigu Liu, Daizhi Yang, Hongrong Deng, Xubin Yang, Jing Lv, Wen Xu, Jinhua Yan
BMJ Open.2023; 13(8): e073263. CrossRef
Barriers to Uptake of Open-Source Automated Insulin Delivery Systems: Analysis of Socioeconomic Factors and Perceived Challenges of Caregivers of Children and Adolescents With Type 1 Diabetes From the OPEN Survey
Antonia Huhndt, Yanbing Chen, Shane O’Donnell, Drew Cooper, Hanne Ballhausen, Katarzyna A. Gajewska, Timothée Froment, Mandy Wäldchen, Dana M. Lewis, Klemens Raile, Timothy C. Skinner, Katarina Braune
Frontiers in Clinical Diabetes and Healthcare.2022;[Epub] CrossRef
Toward Personalized Hemoglobin A1c Estimation for Type 2 Diabetes
Namho Kim, Da Young Lee, Wonju Seo, Nan Hee Kim, Sung-Min Park
IEEE Sensors Journal.2022; 22(23): 23023. CrossRef

First
Prev
Page of 2
Next
Last

Previous issues