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Volume 43(3); June 2019
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Sulwon Lecture 2018
Pathophysiology
Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation
Chang-Yun Woo, Jung Eun Jang, Seung Eun Lee, Eun Hee Koh, Ki-Up Lee
Diabetes Metab J. 2019;43(3):247-256.   Published online March 27, 2019
DOI: https://doi.org/10.4093/dmj.2018.0221
  • 9,017 View
  • 263 Download
  • 72 Web of Science
  • 73 Crossref
AbstractAbstract PDFPubReader   

Adipose tissue inflammation is considered a major contributing factor in the development of obesity-associated insulin resistance and cardiovascular diseases. However, the cause of adipose tissue inflammation is presently unclear. The role of mitochondria in white adipocytes has long been neglected because of their low abundance. However, recent evidence suggests that mitochondria are essential for maintaining metabolic homeostasis in white adipocytes. In a series of recent studies, we found that mitochondrial function in white adipocytes is essential to the synthesis of adiponectin, which is the most abundant adipokine synthesized from adipocytes, with many favorable effects on metabolism, including improvement of insulin sensitivity and reduction of atherosclerotic processes and systemic inflammation. From these results, we propose a new hypothesis that mitochondrial dysfunction in adipocytes is a primary cause of adipose tissue inflammation and compared this hypothesis with a prevailing concept that “adipose tissue hypoxia” may underlie adipose tissue dysfunction in obesity. Recent studies have emphasized the role of the mitochondrial quality control mechanism in maintaining mitochondrial function. Future studies are warranted to test whether an inadequate mitochondrial quality control mechanism is responsible for mitochondrial dysfunction in adipocytes and adipose tissue inflammation.

Citations

Citations to this article as recorded by  
  • Prolonged Endurance Exercise Increases Macrophage Content and Mitochondrial Respiration in Adipose Tissue in Trained Men
    Ronni Eg Sahl, Ioanna Patsi, Mikkel Thunestvedt Hansen, Tue Rømer, Jacob Frandsen, Hanne Kruuse Rasmusen, Arthur Ingersen, Steen Seier Poulsen, Flemming Dela, Steen Larsen, Jørn Wulff Helge
    The Journal of Clinical Endocrinology & Metabolism.2024; 109(2): e799.     CrossRef
  • The Role of Ion-Transporting Proteins in Human Disease
    Yoshinori Marunaka
    International Journal of Molecular Sciences.2024; 25(3): 1726.     CrossRef
  • The Role of Obesity in Type 2 Diabetes Mellitus—An Overview
    Preethi Chandrasekaran, Ralf Weiskirchen
    International Journal of Molecular Sciences.2024; 25(3): 1882.     CrossRef
  • The Metabolic Syndrome, a Human Disease
    Marià Alemany
    International Journal of Molecular Sciences.2024; 25(4): 2251.     CrossRef
  • Inflammation‐mediated metabolic regulation in adipose tissue
    Shujie Xu, Feng Lu, Jianhua Gao, Yi Yuan
    Obesity Reviews.2024;[Epub]     CrossRef
  • Sleeve Gastrectomy Reduces Oxidative Stress and Reverses Mitochondrial Dysfunction Associated with Metabolic Syndrome
    Micaela M. Rossi, Franco J. Signorini, Tomas A. Castillo, María P. Scribano Parada, Federico Moser, Maria dC Baez
    Obesity Surgery.2024; 34(6): 2042.     CrossRef
  • The relationships between high-fat diet and metabolic syndrome: Potential mechanisms
    Chao Tang, Yuxin Wang, Zeyu Xu, Dan Chen, Jingguo Xu, Duo Yang, Li Zhang, Jun Liu, Juan Kan
    Food Bioscience.2024; 59: 104261.     CrossRef
  • Obesity, Dietary Patterns, and Hormonal Balance Modulation: Gender-Specific Impacts
    Elisa Mazza, Ersilia Troiano, Yvelise Ferro, Fabrizia Lisso, Martina Tosi, Ettore Turco, Roberta Pujia, Tiziana Montalcini
    Nutrients.2024; 16(11): 1629.     CrossRef
  • Mitochondrial quality control in human health and disease
    Bo-Hao Liu, Chen-Zhen Xu, Yi Liu, Zi-Long Lu, Ting-Lv Fu, Guo-Rui Li, Yu Deng, Guo-Qing Luo, Song Ding, Ning Li, Qing Geng
    Military Medical Research.2024;[Epub]     CrossRef
  • Could very low-calorie ketogenic diets turn off low grade inflammation in obesity? Emerging evidence
    Luigi Barrea, Massimiliano Caprio, Mikiko Watanabe, Giuseppe Cammarata, Alessandra Feraco, Giovanna Muscogiuri, Ludovica Verde, Annamaria Colao, Silvia Savastano
    Critical Reviews in Food Science and Nutrition.2023; 63(26): 8320.     CrossRef
  • The emergent role of mitochondrial RNA modifications in metabolic alterations
    Hatim Boughanem, Yvonne Böttcher, João Tomé‐Carneiro, María‐Carmen López de las Hazas, Alberto Dávalos, Akin Cayir, Manuel Macias‐González
    WIREs RNA.2023;[Epub]     CrossRef
  • Age‐associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis
    Jianrui Song, Diana Farris, Paola Ariza, Smriti Moorjani, Mita Varghese, Muriel Blin, Judy Chen, Daniel Tyrrell, Min Zhang, Kanakadurga Singer, Morgan Salmon, Daniel R. Goldstein
    Aging Cell.2023;[Epub]     CrossRef
  • Obesity, diabetes mellitus, and cardiometabolic risk: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2023
    Harold Edward Bays, Shagun Bindlish, Tiffany Lowe Clayton
    Obesity Pillars.2023; 5: 100056.     CrossRef
  • A role of STING signaling in obesity-induced lung inflammation
    Yong Qi, Zhuhua Wu, Dan Chen, Li Zhu, Yunlei Yang
    International Journal of Obesity.2023; 47(4): 325.     CrossRef
  • Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction
    Alina Kuryłowicz
    Biomedicines.2023; 11(3): 690.     CrossRef
  • White Adipose Tissue Dysfunction: Pathophysiology and Emergent Measurements
    Natalia Santillana, Camila Astudillo-Guerrero, Amanda D’Espessailles, Gonzalo Cruz
    Nutrients.2023; 15(7): 1722.     CrossRef
  • Pleiotropic and multi-systemic actions of physical exercise on PGC-1α signaling during the aging process
    Ivo Vieira de Sousa Neto, Ana Paula Pinto, Vitor Rosetto Muñoz, Rita de Cássia Marqueti, José Rodrigo Pauli, Eduardo Rochete Ropelle, Adelino Sanchez Ramos da Silva
    Ageing Research Reviews.2023; 87: 101935.     CrossRef
  • The impact of metabolic endotoxaemia on the browning process in human adipocytes
    Farah Omran, Alice M. Murphy, Awais Z. Younis, Ioannis Kyrou, Jana Vrbikova, Vojtech Hainer, Petra Sramkova, Martin Fried, Graham Ball, Gyanendra Tripathi, Sudhesh Kumar, Philip G. McTernan, Mark Christian
    BMC Medicine.2023;[Epub]     CrossRef
  • Molecular Mechanisms of Obesity-Induced Development of Insulin Resistance and Promotion of Amyloid-β Accumulation: Dietary Therapy Using Weak Organic Acids via Improvement of Lowered Interstitial Fluid pH
    Yoshinori Marunaka
    Biomolecules.2023; 13(5): 779.     CrossRef
  • From Obesity-Induced Low-Grade Inflammation to Lipotoxicity and Mitochondrial Dysfunction: Altered Multi-Crosstalk between Adipose Tissue and Metabolically Active Organs
    Gina Cavaliere, Fabiano Cimmino, Giovanna Trinchese, Angela Catapano, Lidia Petrella, Margherita D’Angelo, Lucio Lucchin, Maria Pina Mollica
    Antioxidants.2023; 12(6): 1172.     CrossRef
  • Receptor for the Advanced Glycation End Products (RAGE) Pathway in Adipose Tissue Metabolism
    Klaudia Gutowska, Krzysztof Czajkowski, Alina Kuryłowicz
    International Journal of Molecular Sciences.2023; 24(13): 10982.     CrossRef
  • Aerobic and Resistance Training Attenuate Differently Knee Joint Damage Caused by a High-Fat–High-Sucrose Diet in a Rat Model
    Nada Abughazaleh, Kevin Boldt, Jaqueline Lourdes Rios, Stela Marcia Mattiello, Kelsey H. Collins, Ruth-Anne Seerattan, Walter Herzog
    CARTILAGE.2023;[Epub]     CrossRef
  • Exercise mitigates age-related metabolic diseases by improving mitochondrial dysfunction
    Dandan Jia, Zhenjun Tian, Ru Wang
    Ageing Research Reviews.2023; 91: 102087.     CrossRef
  • Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging
    Ines Martic, Federica Papaccio, Barbara Bellei, Maria Cavinato
    Frontiers in Physiology.2023;[Epub]     CrossRef
  • Diabetes Mellitus, Energy Metabolism, and COVID-19
    Caterina Conte, Elisa Cipponeri, Michael Roden
    Endocrine Reviews.2023;[Epub]     CrossRef
  • Influence of Breastfeeding on the State of Meta-Inflammation in Obesity—A Narrative Review
    Dominika Mazur, Małgorzata Satora, Anna K. Rekowska, Zuzanna Kabała, Aleksandra Łomża, Żaneta Kimber-Trojnar, Bożena Leszczyńska-Gorzelak
    Current Issues in Molecular Biology.2023; 45(11): 9003.     CrossRef
  • AGER-1 Long Non-Coding RNA Levels Correlate with the Expression of the Advanced Glycosylation End-Product Receptor, a Regulator of the Inflammatory Response in Visceral Adipose Tissue of Women with Obesity and Type 2 Diabetes Mellitus
    Klaudia Gutowska, Krzysztof Koźniewski, Michał Wąsowski, Marta Izabela Jonas, Zbigniew Bartoszewicz, Wojciech Lisik, Maurycy Jonas, Artur Binda, Paweł Jaworski, Wiesław Tarnowski, Bartłomiej Noszczyk, Monika Puzianowska-Kuźnicka, Krzysztof Czajkowski, Ali
    International Journal of Molecular Sciences.2023; 24(24): 17447.     CrossRef
  • Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis
    Cong Liu, Milena Schönke, Enchen Zhou, Zhuang Li, Sander Kooijman, Mariëtte R Boon, Mikael Larsson, Kristina Wallenius, Niek Dekker, Louise Barlind, Xiao-Rong Peng, Yanan Wang, Patrick C N Rensen
    Cardiovascular Research.2022; 118(2): 489.     CrossRef
  • Obesity-Related Adipose Tissue Remodeling in the Light of Extracellular Mitochondria Transfer
    Simon Lecoutre, Karine Clément, Isabelle Dugail
    International Journal of Molecular Sciences.2022; 23(2): 632.     CrossRef
  • IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity
    Tuan Anh Phu, Martin Ng, Ngan K. Vu, Laura Bouchareychas, Robert L. Raffai
    Molecular Therapy.2022; 30(6): 2274.     CrossRef
  • Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes
    Maria A. Ahonen, Marcus Höring, Van Dien Nguyen, Sami Qadri, Juuso H. Taskinen, Meghana Nagaraj, Martin Wabitsch, Pamela Fischer-Posovszky, You Zhou, Gerhard Liebisch, P. A. Nidhina Haridas, Hannele Yki-Järvinen, Vesa M. Olkkonen
    Molecular Medicine.2022;[Epub]     CrossRef
  • Modulation of adipose inflammation by cellular retinoic acid-binding protein 1
    Chin-Wen Wei, Jennifer Nhieu, Yu-Lung Lin, Li-Na Wei
    International Journal of Obesity.2022; 46(10): 1759.     CrossRef
  • The Role of Adipokines in Pancreatic Cancer
    Qi Wang, Huizhi Wang, Yuntao Ding, Mengtian Wan, Min Xu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes
    Federica Zatterale, Gregory Alexander Raciti, Immacolata Prevenzano, Alessia Leone, Michele Campitelli, Veronica De Rosa, Francesco Beguinot, Luca Parrillo
    Biomolecules.2022; 12(7): 982.     CrossRef
  • Cellular Metabolism and Bioenergetic Function in Human Fibroblasts and Preadipocytes of Type 2 Familial Partial Lipodystrophy
    Cristina Algieri, Chiara Bernardini, Fabiana Trombetti, Elisa Schena, Augusta Zannoni, Monica Forni, Salvatore Nesci
    International Journal of Molecular Sciences.2022; 23(15): 8659.     CrossRef
  • Shared pathobiology identifies AMPK as a therapeutic target for obesity and autosomal dominant polycystic kidney disease
    Ioan-Andrei Iliuta, Xuewen Song, Lauren Pickel, Amirreza Haghighi, Ravi Retnakaran, James Scholey, Hoon-Ki Sung, Gregory R. Steinberg, York Pei
    Frontiers in Molecular Biosciences.2022;[Epub]     CrossRef
  • Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities
    Ruwen Wang, Qin Sun, Xianmin Wu, Yiyin Zhang, Xiaorui Xing, Kaiqing Lin, Yue Feng, Mingqi Wang, Yibing Wang, Ru Wang
    Cells.2022; 11(23): 3735.     CrossRef
  • Macrophage and Adipocyte Mitochondrial Dysfunction in Obesity-Induced Metabolic Diseases
    Liwen Wang, Jie Hu, Haiyan Zhou
    The World Journal of Men's Health.2021; 39(4): 606.     CrossRef
  • ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota
    Sup Kim, June-Young Lee, Seul Gi Shin, Jin Kyung Kim, Prashanta Silwal, Young Jae Kim, Na-Ri Shin, Pil Soo Kim, Minho Won, Sang-Hee Lee, Soo Yeon Kim, Miwa Sasai, Masahiro Yamamoto, Jin-Man Kim, Jin-Woo Bae, Eun-Kyeong Jo
    Autophagy.2021; 17(10): 2856.     CrossRef
  • GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH
    Kook Hwan Kim, Myung-Shik Lee
    Biochimica et Biophysica Acta (BBA) - General Subjects.2021; 1865(3): 129834.     CrossRef
  • The Influence of Obesity and Associated Fatty Acids on Placental Inflammation
    Alison J. Eastman, Rebecca E. Moore, Steven D. Townsend, Jennifer A. Gaddy, David M. Aronoff
    Clinical Therapeutics.2021; 43(2): 265.     CrossRef
  • Targeting the G protein-coupled estrogen receptor (GPER) in obesity and diabetes
    Geetanjali Sharma, Eric R. Prossnitz
    Endocrine and Metabolic Science.2021; 2: 100080.     CrossRef
  • Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome
    Yun Hwan Oh, Seulggie Choi, Gyeongsil Lee, Joung Sik Son, Kyae Hyung Kim, Sang Min Park
    Journal of Clinical Medicine.2021; 10(4): 745.     CrossRef
  • N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases
    Ye-shi Chen, Xin-ping Ouyang, Xiao-hua Yu, Petr Novák, Le Zhou, Ping-ping He, Kai Yin
    Journal of Cardiovascular Translational Research.2021; 14(5): 857.     CrossRef
  • From Metabolic Syndrome to Neurological Diseases: Role of Autophagy
    Jessica Maiuolo, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Federica Scarano, Saverio Nucera, Miriam Scicchitano, Francesca Bosco, Stefano Ruga, Maria Caterina Zito, Roberta Macri, Rosamaria Bulotta, Carolina Muscoli, Vincenzo Mollace
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Absent Exercise-Induced Improvements in Fat Oxidation in Women With Polycystic Ovary Syndrome After High-Intensity Interval Training
    Sofie Lionett, Ida Almenning Kiel, Ragnhild Røsbjørgen, Stian Lydersen, Steen Larsen, Trine Moholdt
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance
    Yoshinori Marunaka
    Biochemical Society Transactions.2021; 49(2): 715.     CrossRef
  • The Role of Mitochondrial Adaptation and Metabolic Flexibility in the Pathophysiology of Obesity and Insulin Resistance: an Updated Overview
    Dimitrios Tsilingiris, Evangelia Tzeravini, Chrysi Koliaki, Maria Dalamaga, Alexander Kokkinos
    Current Obesity Reports.2021; 10(3): 191.     CrossRef
  • Obesity-Related Inflammation and Endothelial Dysfunction in COVID-19: Impact on Disease Severity
    Andrea De Lorenzo, Vanessa Estato, Hugo C Castro-Faria-Neto, Eduardo Tibirica
    Journal of Inflammation Research.2021; Volume 14: 2267.     CrossRef
  • Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential
    Bruna B. Brandão, Ankita Poojari, Atefeh Rabiee
    International Journal of Molecular Sciences.2021; 22(11): 5906.     CrossRef
  • Metabolic Syndrome in an Aging Society – Role of Oxidant-Antioxidant Imbalance and Inflammation Markers in Disentangling Atherosclerosis
    Sylwia Dziegielewska-Gesiak
    Clinical Interventions in Aging.2021; Volume 16: 1057.     CrossRef
  • Recruitment and remodeling of peridroplet mitochondria in human adipose tissue
    Rebeca Acín-Perez, Anton Petcherski, Michaela Veliova, Ilan Y. Benador, Essam A. Assali, Georgia Colleluori, Saverio Cinti, Alexandra J. Brownstein, Siyouneh Baghdasarian, Masha J. Livhits, Michael W. Yeh, Karthickeyan Chella Krishnan, Laurent Vergnes, Na
    Redox Biology.2021; 46: 102087.     CrossRef
  • New Insights Into Mitochondrial Dysfunction at Disease Susceptibility Loci in the Development of Type 2 Diabetes
    Hannah Maude, Winston Lau, Nikolas Maniatis, Toby Andrew
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Effects of sleeve gastrectomy on bone mass, microstructure of femurs and bone metabolism associated serum factors in obese rats
    Ying Xue, Ran Li, Yong Zhao, Ling Li, Yun Zhou
    BMC Endocrine Disorders.2021;[Epub]     CrossRef
  • The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice
    Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer
    Scientific Reports.2021;[Epub]     CrossRef
  • Reliability and variation in mitochondrial respiration in human adipose tissue
    Ronni Eg Sahl, Eva Frederikke Høy Helms, Malte Schmücker, Mathias Flensted-Jensen, Arthur Ingersen, Thomas Morville, Flemming Dela, Jørn Wulff Helge, Steen Larsen
    Adipocyte.2021; 10(1): 605.     CrossRef
  • Inhibition of protein tyrosine phosphatase improves mitochondrial bioenergetics and dynamics, reduces oxidative stress, and enhances adipogenic differentiation potential in metabolically impaired progenitor stem cells
    Katarzyna Kornicka-Garbowska, Lynda Bourebaba, Michael Röcken, Krzysztof Marycz
    Cell Communication and Signaling.2021;[Epub]     CrossRef
  • microRNAs in Human Adipose Tissue Physiology and Dysfunction
    Alina Kurylowicz
    Cells.2021; 10(12): 3342.     CrossRef
  • Aging, obese-insulin resistance, and bone remodeling
    Napatsorn Imerb, Chanisa Thonusin, Nipon Chattipakorn, Siriporn C. Chattipakorn
    Mechanisms of Ageing and Development.2020; 191: 111335.     CrossRef
  • Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
    Federica Zatterale, Michele Longo, Jamal Naderi, Gregory Alexander Raciti, Antonella Desiderio, Claudia Miele, Francesco Beguinot
    Frontiers in Physiology.2020;[Epub]     CrossRef
  • Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?
    Alexis Diaz-Vegas, Pablo Sanchez-Aguilera, James R Krycer, Pablo E Morales, Matías Monsalves-Alvarez, Mariana Cifuentes, Beverly A Rothermel, Sergio Lavandero
    Endocrine Reviews.2020;[Epub]     CrossRef
  • Inflammatory Signaling and Brown Fat Activity
    Farah Omran, Mark Christian
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Omega-3 fatty acids as regulators of brown/beige adipose tissue: from mechanisms to therapeutic potential
    Marta Fernández-Galilea, Elisa Félix-Soriano, Ignacio Colón-Mesa, Xavier Escoté, Maria J. Moreno-Aliaga
    Journal of Physiology and Biochemistry.2020; 76(2): 251.     CrossRef
  • Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes
    Alina Kuryłowicz, Krzysztof Koźniewski
    Molecules.2020; 25(9): 2224.     CrossRef
  • Obese Adipose Tissue Secretion Induces Inflammation in Preadipocytes: Role of Toll-Like Receptor-4
    Mariana Renovato-Martins, Catharina Moreira-Nunes, Georgia C. Atella, Christina Barja-Fidalgo, João Alfredo de Moraes
    Nutrients.2020; 12(9): 2828.     CrossRef
  • Diabetes and Metabolism Journal in 2020: Good to Great
    In-Kyung Jeong
    Diabetes & Metabolism Journal.2020; 44(1): 1.     CrossRef
  • The Effect of Silibinin on Protein Expression Profile in White Adipose Tissue of Obese Mice
    Fei Wang, Shuchun Chen, Luping Ren, Yichao Wang, Zelin Li, Tiantian Song, He Zhang, Qiwen Yang
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • Beneficial Effects of Bariatric Surgery-Induced by Weight Loss on the Proteome of Abdominal Subcutaneous Adipose Tissue
    Bárbara María Varela-Rodríguez, Paula Juiz-Valiña, Luis Varela, Elena Outeiriño-Blanco, Susana Belén Bravo, María Jesús García-Brao, Enrique Mena, José Francisco Noguera, Javier Valero-Gasalla, Fernando Cordido, Susana Sangiao-Alvarellos
    Journal of Clinical Medicine.2020; 9(1): 213.     CrossRef
  • Impact of Skeletal Muscle Mass on Metabolic Health
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    Endocrinology and Metabolism.2020; 35(1): 1.     CrossRef
  • Sea buckthorn (Hippophae rhamnoides L.) oil enhances proliferation, adipocytes differentiation and insulin sensitivity in 3T3-L1 cells
    Ting Zhang, Xuze Qin, Yuxin Cao, Jianxin Zhang, Junxing Zhao
    Food Science and Biotechnology.2020; 29(11): 1511.     CrossRef
  • Adipose tissue secretory profile and cardiometabolic risk in obesity
    Pengcheng Zhang, Daniels Konja, Yu Wang
    Endocrine and Metabolic Science.2020; 1(3-4): 100061.     CrossRef
  • Mitochondrial Dynamics in the Brain Are Associated With Feeding, Glucose Homeostasis, and Whole-Body Metabolism
    Jessica L. Haigh, Lauryn E. New, Beatrice M. Filippi
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Adipogenesis: A Necessary but Harmful Strategy
    Mohammed El Hafidi, Mabel Buelna-Chontal, Fausto Sánchez-Muñoz, Roxana Carbó
    International Journal of Molecular Sciences.2019; 20(15): 3657.     CrossRef
Review
Obesity and Metabolic Syndrome
Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets
Jessica M. Ferrell, John Y. L. Chiang
Diabetes Metab J. 2019;43(3):257-272.   Published online June 13, 2019
DOI: https://doi.org/10.4093/dmj.2019.0043
  • 9,413 View
  • 252 Download
  • 67 Web of Science
  • 74 Crossref
AbstractAbstract PDFPubReader   

Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in the intestine by gut bacteria. Bile acids are nutrient sensors and metabolic integrators that regulate lipid, glucose, and energy homeostasis by activating nuclear farnesoid X receptor and membrane Takeda G protein-coupled receptor 5. Bile acids control gut bacteria overgrowth, species population, and protect the integrity of the intestinal barrier. Gut bacteria, in turn, control circulating bile acid composition and pool size. Dysregulation of bile acid homeostasis and dysbiosis causes diabetes and obesity. Targeting bile acid signaling and the gut microbiome have therapeutic potential for treating diabetes, obesity, and non-alcoholic fatty liver disease.

Citations

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  • Gut microbiome-derived secondary bile acids: therapeutic targets for reducing cardiovascular disease in type 2 diabetes?
    Sarah A. Johnson, Tiffany L. Weir
    The American Journal of Clinical Nutrition.2024; 119(2): 241.     CrossRef
  • Current updates on metabolites and its interlinked pathways as biomarkers for diabetic kidney disease: A systematic review
    Soumik Das, V Devi Rajeswari, Ganesh Venkatraman, Ramprasad Elumalai, Sivaraman Dhanasekaran, Gnanasambandan Ramanathan
    Translational Research.2024; 265: 71.     CrossRef
  • Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes
    Kai Luo, Guo-Chong Chen, Yanbo Zhang, Jee-Young Moon, Jiaqian Xing, Brandilyn A. Peters, Mykhaylo Usyk, Zheng Wang, Gang Hu, Jun Li, Elizabeth Selvin, Casey M. Rebholz, Tao Wang, Carmen R. Isasi, Bing Yu, Rob Knight, Eric Boerwinkle, Robert D. Burk, Rober
    Nature Metabolism.2024; 6(1): 169.     CrossRef
  • Predictive value of serum TBA for 2-year MACEs in ACS patients undergoing PCI: a prospective cohort study
    Wen Wen, Qinze Li, Jianqing She, Xiaofang Bai, Lisha Zhang, Ruifeng Li, Yan Wu, Juan Zhou, Zuyi Yuan
    Scientific Reports.2024;[Epub]     CrossRef
  • Collaborative Metabolism: Gut Microbes Play a Key Role in Canine and Feline Bile Acid Metabolism
    John C. Rowe, Jenessa A. Winston
    Veterinary Sciences.2024; 11(2): 94.     CrossRef
  • The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation
    Olga Golubnitschaja, Jiri Polivka, Pavel Potuznik, Martin Pesta, Ivana Stetkarova, Alena Mazurakova, Lenka Lackova, Peter Kubatka, Martina Kropp, Gabriele Thumann, Carl Erb, Holger Fröhlich, Wei Wang, Babak Baban, Marko Kapalla, Niva Shapira, Kneginja Ric
    EPMA Journal.2024; 15(1): 1.     CrossRef
  • Investigating the mechanism of cornel iridoid glycosides on type 2 diabetes mellitus using serum and urine metabolites in rats
    Yadi Hou, Yanmei Huang, Zihui Shang, Shichao Ma, Tianyi Cui, Ali Chen, Yongxia Cui, Suiqing Chen
    Journal of Ethnopharmacology.2024; 328: 118065.     CrossRef
  • Unravelling the therapeutic landscape of bile acid-based therapies in gastrointestinal disorders
    Bandar D. Alrehaili
    Saudi Journal of Gastroenterology.2024;[Epub]     CrossRef
  • Cichorium glandulosum Ameliorates HFD-Induced Obesity in Mice by Modulating Gut Microbiota and Bile Acids
    Yewei Zhong, Hurxida Emam, Wenhui Hou, Junlin Yan, Adalaiti Abudurexiti, Rui Zhang, Shuwen Qi, Yi Lei, Xiaoli Ma
    Journal of Medicinal Food.2024;[Epub]     CrossRef
  • Exercise Training Independent of Intensity Lowers Plasma Bile Acids in Prediabetes
    STEVEN K. MALIN, U.S. AFSHEEN SYEDA
    Medicine & Science in Sports & Exercise.2024; 56(6): 1009.     CrossRef
  • Production of deoxycholic acid by low-abundant microbial species is associated with impaired glucose metabolism
    Annika Wahlström, Ariel Brumbaugh, Wilhelm Sjöland, Lisa Olsson, Hao Wu, Marcus Henricsson, Annika Lundqvist, Kassem Makki, Stanley L. Hazen, Göran Bergström, Hanns-Ulrich Marschall, Michael A. Fischbach, Fredrik Bäckhed
    Nature Communications.2024;[Epub]     CrossRef
  • Dysregulated bile acid homeostasis: unveiling its role in metabolic diseases
    Yanyan Wang, Huangru Xu, Xiqiao Zhou, Weidong Chen, Huiping Zhou
    Medical Review.2024;[Epub]     CrossRef
  • Improvement of myocardial injury and gut microbiota disturbance in type 2 diabetic mice by inulin with various degrees of polymerization
    Siqiang Jia, Jianpeng Li, Bin Yu, Mengjie Li, Bo Cui
    Food Bioscience.2023; 51: 102318.     CrossRef
  • Bile acids and their receptors in regulation of gut health and diseases
    Sen Lin, Sutian Wang, Peng Wang, Cuiming Tang, Zhenjiang Wang, Lian Chen, Guoqing Luo, Hong Chen, Yuntao Liu, Bin Feng, De Wu, Douglas G. Burrin, Zhengfeng Fang
    Progress in Lipid Research.2023; 89: 101210.     CrossRef
  • Effects of dietary oat supplementation on carcass traits, muscle metabolites, amino acid profiles, and its association with meat quality of Small-tail Han sheep
    Li-wei Wang, Shao-feng Su, Jie Zhao, Xiao-long He, Shao-yin Fu, Biao Wang, Yun-fei Wang, Da-qing Wang, Na-na Yun, Xin Chen, Damien P Belobrajdic, Terigele, Xiao-dong Li, Li-li Jiang, Jiang-feng He, Yong-bin Liu
    Food Chemistry.2023; 411: 135456.     CrossRef
  • Noni (Morinda citrifolia L.) fruit polysaccharide ameliorated high-fat diet-induced obesity by modulating gut microbiota and improving bile acid metabolism
    Wenjing Mo, Jiaqi Zou, Ming Wu, Zijun Peng, Wenjiang He, Wenzhi Li, Xiaoyong Wu
    Journal of Functional Foods.2023; 101: 105408.     CrossRef
  • Sodium glucose co-transporter 2 (SGLT2) inhibition via dapagliflozin improves diabetic kidney disease (DKD) over time associatied with increasing effect on the gut microbiota in db/db mice
    Jiajia Wu, Yan Chen, Huinan Yang, Leyi Gu, Zhaohui Ni, Shan Mou, Jianxiao Shen, Xiajing Che
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Short communication: unique metabolic signature of proliferative retinopathy in the tear fluid of diabetic patients with comorbidities — preliminary data for PPPM validation
    Martina Kropp, Eline De Clerck, Trong-Tin Kevin Steve Vo, Gabriele Thumann, Vincenzo Costigliola, Olga Golubnitschaja
    EPMA Journal.2023; 14(1): 43.     CrossRef
  • Impact of Vancomycin Treatment and Gut Microbiota on Bile Acid Metabolism and the Development of Non-Alcoholic Steatohepatitis in Mice
    Kaichi Kasai, Naoya Igarashi, Yuki Tada, Koudai Kani, Shun Takano, Tsutomu Yanagibashi, Fumitake Usui-Kawanishi, Shiho Fujisaka, Shiro Watanabe, Mayuko Ichimura-Shimizu, Kiyoshi Takatsu, Kazuyuki Tobe, Koichi Tsuneyama, Yukihiro Furusawa, Yoshinori Nagai
    International Journal of Molecular Sciences.2023; 24(4): 4050.     CrossRef
  • Mitochondrial Cholesterol Metabolites in a Bile Acid Synthetic Pathway Drive Nonalcoholic Fatty Liver Disease: A Revised “Two-Hit” Hypothesis
    Genta Kakiyama, Daniel Rodriguez-Agudo, William M. Pandak
    Cells.2023; 12(10): 1434.     CrossRef
  • Bile acid metabolism and signaling: Emerging pharmacological targets of dietary polyphenols
    Kevin M. Tveter, Esther Mezhibovsky, Yue Wu, Diana E. Roopchand
    Pharmacology & Therapeutics.2023; 248: 108457.     CrossRef
  • Role of liver parameters in diabetes mellitus – a narrative review
    Sana Rafaqat, Aqsa Sattar, Amber Khalid, Saira Rafaqat
    Endocrine Regulations.2023; 57(1): 200.     CrossRef
  • Bile acids induce IL-1α and drive NLRP3 inflammasome-independent production of IL-1β in murine dendritic cells
    Ewa Oleszycka, Eoin C. O’Brien, Michael Freeley, Ed C. Lavelle, Aideen Long
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Machine learning for predicting diabetic metabolism in the Indian population using polar metabolomic and lipidomic features
    Nikita Jain, Bhaumik Patel, Manjesh Hanawal, Anurag R. Lila, Saba Memon, Tushar Bandgar, Ashutosh Kumar
    Metabolomics.2023;[Epub]     CrossRef
  • The mitochondrial translocator protein (TSPO, 18 kDa): A key multifunctional molecule in liver diseases
    Yuchang Li, Liting Chen, Vassilios Papadopoulos
    Biochimie.2023;[Epub]     CrossRef
  • Sodium+/taurocholate cotransporting polypeptide as target therapy for liver fibrosis
    Ahmad Salhab, Johnny Amer, Yinying Lu, Rifaat Safadi
    Gut.2022; 71(7): 1373.     CrossRef
  • Comparative Evaluation of the Effect of Metformin and Insulin on Gut Microbiota and Metabolome Profiles of Type 2 Diabetic Rats Induced by the Combination of Streptozotocin and High-Fat Diet
    Nan Hu, Qi Zhang, Hui Wang, Xuping Yang, Yan Jiang, Rong Chen, Liying Wang
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Immunomodulatory functions of FXR
    Stefano Fiorucci, Angela Zampella, Patrizia Ricci, Eleonora Distrutti, Michele Biagioli
    Molecular and Cellular Endocrinology.2022; 551: 111650.     CrossRef
  • Production of New Microbially Conjugated Bile Acids by Human Gut Microbiota
    Carlos J. Garcia, Vit Kosek, David Beltrán, Francisco A. Tomás-Barberán, Jana Hajslova
    Biomolecules.2022; 12(5): 687.     CrossRef
  • Regulation of the intestinal flora: A potential mechanism of natural medicines in the treatment of type 2 diabetes mellitus
    liying he, Fang-Qing Yang, Pan Tang, Ting-Hui Gao, Cai-Xia Yang, Li Tan, Pan Yue, Ya-Nan Hua, Si-Jing Liu, Jin-Lin Guo
    Biomedicine & Pharmacotherapy.2022; 151: 113091.     CrossRef
  • Acrylamide induced glucose metabolism disorder in rats involves gut microbiota dysbiosis and changed bile acids metabolism
    Zonghao Yue, Yanjuan Chen, Qian Dong, Dan Li, Meng Guo, Li Zhang, Yini Shi, Huiting Wu, Lili Li, Zhongke Sun
    Food Research International.2022; 157: 111405.     CrossRef
  • Effects of Herbal Therapy on Intestinal Microbiota and Serum Metabolomics in Different Rat Models of Mongolian Medicine
    Guniang Jiu, Riao Dao, Dongxing Wu, Wang Hung, Haburi Jin, Li Li, Xiquan Fu, Chula Sa, Eerdunchaolu, Maulidiani .M
    Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
  • The role of immune cells in the liver tumor microenvironment: an involvement of gut microbiota-derived factors
    Tomonori Kamiya, Naoko Ohtani
    International Immunology.2022; 34(9): 467.     CrossRef
  • Reduced Cytokine Tumour Necrosis Factor by Pharmacological Intervention in a Preclinical Study
    Armin Mooranian, Jacqueline Chester, Edan Johnston, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Thomas Foster, Momir Mikov, Hani Al-Salami
    Biomolecules.2022; 12(7): 877.     CrossRef
  • Crisis of the Asian gut: associations among diet, microbiota, and metabolic diseases
    Phatthanaphong THERDTATHA, Akari SHINODA, Jiro NAKAYAMA
    Bioscience of Microbiota, Food and Health.2022; 41(3): 83.     CrossRef
  • Valorization of avocado seeds with antioxidant capacity using pressurized hot water extraction
    Eng Shi Ong, Janelle Low, Joseph Choon Wee Tan, Su Yi Foo, Chen Huei Leo
    Scientific Reports.2022;[Epub]     CrossRef
  • The fungicide prothioconazole and its metabolite prothioconazole-desthio disturbed the liver-gut axis in mice
    Lingyu Hu, Xiaofang Wang, Zhiwei Bao, Qihao Xu, Mingrong Qian, Yuanxiang Jin
    Chemosphere.2022; 307: 136141.     CrossRef
  • Gut Microbiota and Bile Acids Mediate the Clinical Benefits of YH1 in Male Patients with Type 2 Diabetes Mellitus: A Pilot Observational Study
    Yueh-Hsiang Huang, Yi-Hong Wu, Hsiang-Yu Tang, Szu-Tah Chen, Chih-Ching Wang, Wan-Jing Ho, Yi-Hsuan Lin, Geng-Hao Liu, Pei-Yeh Lin, Chi-Jen Lo, Yuan-Ming Yeh, Mei-Ling Cheng
    Pharmaceutics.2022; 14(9): 1857.     CrossRef
  • Gut–Liver Axis and Non-Alcoholic Fatty Liver Disease: A Vicious Circle of Dysfunctions Orchestrated by the Gut Microbiome
    Salvatore Pezzino, Maria Sofia, Gloria Faletra, Chiara Mazzone, Giorgia Litrico, Gaetano La Greca, Saverio Latteri
    Biology.2022; 11(11): 1622.     CrossRef
  • The Role of Bile Acids in Cardiovascular Diseases: from Mechanisms to Clinical Implications
    Shuwen Zhang, Junteng Zhou, Wenchao Wu, Ye Zhu, Xiaojing Liu
    Aging and disease.2022;[Epub]     CrossRef
  • Role of bile acids in overweight and obese children and adolescents
    Cosimo Giannini, Concetta Mastromauro, Serena Scapaticci, Cristina Gentile, Francesco Chiarelli
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Bile acids and microbes in metabolic disease
    Dhiraj Kumar Sah, Archana Arjunan, Sun Young Park, Young Do Jung
    World Journal of Gastroenterology.2022; 28(48): 6846.     CrossRef
  • The Fungicide Prothioconazole and its Metabolite Prothioconazole-Desthio Disturbed the Liver-Gut Axis in Mice
    Yuanxiang Jin, Lingyu Hu, Xiaofang Wang, Zhiwei Bao, Qihao Xu, Mingrong Qian
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • The Critical Effect of Bile Acids in Atherosclerosis
    Shangwen Qi, Xu Luo, Shuangfang Liu, Bishi Ling, Hua Jin
    Journal of Cardiovascular Pharmacology.2022; 80(4): 562.     CrossRef
  • Role of sirtuin-1 (SIRT1) in hypoxic injury in pancreatic β-cells
    Ye-Jee Lee, Esder Lee, Young-Hye You, Yu-Bae Ahn, Ki-Ho Song, Ji-Won Kim, Seung-Hyun Ko
    Journal of Drug Targeting.2021; 29(1): 88.     CrossRef
  • Impact of gut microbiota: How it could play roles beyond the digestive system on development of cardiovascular and renal diseases
    Kanmani Suganya, Taekwon Son, Kyu-Won Kim, Byung-Soo Koo
    Microbial Pathogenesis.2021; 152: 104583.     CrossRef
  • Determination of bile acids from human gallbladder by 1H‐MRS—Protocol optimization and estimation of reproducibility
    Peter Vermathen, Gaëlle Diserens, Dino Kröll, Philipp Nett, Guido Stirnimann, Reiner Wiest
    NMR in Biomedicine.2021;[Epub]     CrossRef
  • The gut microbiome-bile acid axis in hepatocarcinogenesis
    Liwei Wu, Jiao Feng, Jingjing Li, Qiang Yu, Jie Ji, Jianye Wu, Weiqi Dai, Chuanyong Guo
    Biomedicine & Pharmacotherapy.2021; 133: 111036.     CrossRef
  • Gut microbiome and bile acids in obesity-related diseases
    Rumei Li, Sergio Andreu-Sánchez, Folkert Kuipers, Jingyuan Fu
    Best Practice & Research Clinical Endocrinology & Metabolism.2021; 35(3): 101493.     CrossRef
  • Gut Microbiome of Indonesian Adults Associated with Obesity and Type 2 Diabetes: A Cross-Sectional Study in an Asian City, Yogyakarta
    Phatthanaphong Therdtatha, Yayi Song, Masaru Tanaka, Mariyatun Mariyatun, Maisaroh Almunifah, Nancy Eka Putri Manurung, Siska Indriarsih, Yi Lu, Koji Nagata, Katsuya Fukami, Tetsuo Ikeda, Yuan-Kun Lee, Endang Sutriswati Rahayu, Jiro Nakayama
    Microorganisms.2021; 9(5): 897.     CrossRef
  • Microbial Ecosystem in Diabetes Mellitus: Consideration of the Gastrointestinal System
    Awgichew Shewasinad Yehualashet, Berhan Begashaw Yikna
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 1841.     CrossRef
  • Role of bile acids in inflammatory liver diseases
    Ioannis Evangelakos, Joerg Heeren, Esther Verkade, Folkert Kuipers
    Seminars in Immunopathology.2021; 43(4): 577.     CrossRef
  • Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes
    Alessandro Mantovani, Andrea Dalbeni, Denise Peserico, Filippo Cattazzo, Michele Bevilacqua, Gian Luca Salvagno, Giuseppe Lippi, Giovanni Targher, Elisa Danese, Cristiano Fava
    Metabolites.2021; 11(7): 453.     CrossRef
  • Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice
    Xue-Song Zhang, Yue Sandra Yin, Jincheng Wang, Thomas Battaglia, Kimberly Krautkramer, Wei Vivian Li, Jackie Li, Mark Brown, Meifan Zhang, Michelle H. Badri, Abigail J.S. Armstrong, Christopher M. Strauch, Zeneng Wang, Ina Nemet, Nicole Altomare, Joseph C
    Cell Host & Microbe.2021; 29(8): 1249.     CrossRef
  • Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature
    Sarah Kim, Sora Choi, Moumita Dutta, Jeffrey O. Asubonteng, Marianne Polunas, Michael Goedken, Frank J. Gonzalez, Julia Yue Cui, Maxwell A. Gyamfi
    Biochemical Pharmacology.2021; 193: 114698.     CrossRef
  • Gut microbiota as a target for prevention and treatment of type 2 diabetes: Mechanisms and dietary natural products
    Fan Xia, Lu-Ping Wen, Bing-Chen Ge, Yu-Xin Li, Fang-Ping Li, Ben-Jie Zhou
    World Journal of Diabetes.2021; 12(8): 1146.     CrossRef
  • Association between circulating bile acid alterations and nonalcoholic steatohepatitis independent of obesity and diabetes mellitus
    Youngae Jung, Bo Kyung Koo, Seo Young Jang, Dain Kim, Heeyeon Lee, Dong Hyeon Lee, Sae Kyung Joo, Yong Jin Jung, Jeong Hwan Park, Taekyeong Yoo, Murim Choi, Min Kyung Lee, Sang Won Kang, Mee Soo Chang, Won Kim, Geum‐Sook Hwang
    Liver International.2021; 41(12): 2892.     CrossRef
  • Bile acid activated receptors: Integrating immune and metabolic regulation in non-alcoholic fatty liver disease
    Michele Biagioli, Stefano Fiorucci
    Liver Research.2021; 5(3): 119.     CrossRef
  • Synthesis of 12β-Methyl-18-nor-bile Acids
    Andreas Luxenburger, Lawrence D. Harris, Elizabeth M. Ure, Roselis A. Landaeta Aponte, Anthony D. Woolhouse, Scott A. Cameron, Chris D. Ling, Ross O. Piltz, Andrew R. Lewis, Graeme J. Gainsford, Alex Weymouth-Wilson, Richard H. Furneaux
    ACS Omega.2021; 6(38): 25019.     CrossRef
  • Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification
    Kamil Borkowski, Ameer Y. Taha, Theresa L. Pedersen, Philip L. De Jager, David A. Bennett, Matthias Arnold, Rima Kaddurah-Daouk, John W. Newman
    Scientific Reports.2021;[Epub]     CrossRef
  • Myocardial Infarction and Coronary Artery Disease in Menopausal Women With Type 2 Diabetes Mellitus Negatively Correlate With Total Serum Bile Acids
    Xunxun Feng, Guangyao Zhai, Jiaqi Yang, Yang Liu, Yujie Zhou, Qianyun Guo
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • An Integrated Bile Acids Profile Determination by UHPLC-MS/MS to Identify the Effect of Bile Acids Supplement in High Plant Protein Diet on Common Carp (Cyprinus carpio)
    Xian Wei, Ting Yao, Fatou Ndoye Fall, Min Xue, Xiaofang Liang, Jie Wang, Wenlong Du, Xu Gu
    Foods.2021; 10(10): 2465.     CrossRef
  • Fatty liver index and development of cardiovascular disease in Koreans without pre-existing myocardial infarction and ischemic stroke: a large population-based study
    Jun Hyung Kim, Jin Sil Moon, Seok Joon Byun, Jun Hyeok Lee, Dae Ryong Kang, Ki Chul Sung, Jang Young Kim, Ji Hye Huh
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Methionine restriction alleviates high-fat diet-induced obesity: Involvement of diurnal metabolism of lipids and bile acids
    Luanfeng Wang, Bo Ren, Qian Zhang, Chuanqi Chu, Zhenting Zhao, Jianbin Wu, Weiyang Zhao, Zhigang Liu, Xuebo Liu
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2020; 1866(11): 165908.     CrossRef
  • Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes
    Yingjie Wu, An Zhou, Li Tang, Yuanyuan Lei, Bo Tang, Linjing Zhang
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy
    John Y. L. Chiang, Jessica M. Ferrell
    American Journal of Physiology-Gastrointestinal and Liver Physiology.2020; 318(3): G554.     CrossRef
  • Imidacloprid disturbed the gut barrier function and interfered with bile acids metabolism in mice
    Guiling Yang, Xianling Yuan, Cuiyuan Jin, Dou Wang, Yanhua Wang, Wenyu Miao, Yuanxiang Jin
    Environmental Pollution.2020; 266: 115290.     CrossRef
  • Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis
    John Y.L. Chiang, Jessica M. Ferrell
    Liver Research.2020; 4(2): 47.     CrossRef
  • Diabetes and Metabolism Journal in 2020: Good to Great
    In-Kyung Jeong
    Diabetes & Metabolism Journal.2020; 44(1): 1.     CrossRef
  • Healthy dietary patterns to reduce obesity-related metabolic disease: polyphenol-microbiome interactions unifying health effects across geography
    Camilla Diotallevi, Francesca Fava, Marco Gobbetti, Kieran Tuohy
    Current Opinion in Clinical Nutrition & Metabolic Care.2020; 23(6): 437.     CrossRef
  • Metabolic profiling of pre-gestational and gestational diabetes mellitus identifies novel predictors of pre-term delivery
    Ilhame Diboun, Manjunath Ramanjaneya, Yasser Majeed, Lina Ahmed, Mohammed Bashir, Alexandra E. Butler, Abdul Badi Abou-Samra, Stephen L. Atkin, Nayef A. Mazloum, Mohamed A. Elrayess
    Journal of Translational Medicine.2020;[Epub]     CrossRef
  • Quantification of common and planar bile acids in tissues and cultured cells
    Stephanie J. Shiffka, Jace W. Jones, Linhao Li, Ann M. Farese, Thomas J. MacVittie, Hongbing Wang, Peter W. Swaan, Maureen A. Kane
    Journal of Lipid Research.2020; 61(11): 1524.     CrossRef
  • Influência da microbiota intestinal na Doença Hepática Gordurosa Não Alcoólica
    Isadora Barbosa de Almeida, Wermerson Assunção Barroso, Caroline Amélia Gonçalves
    Revista Científica Multidisciplinar Núcleo do Conhecimento.2020; : 14.     CrossRef
  • Ultra-Early and Early Changes in Bile Acids and Insulin after Sleeve Gastrectomy among Obese Patients
    Adriana Florinela Cӑtoi, Alina Elena Pârvu, Aurel Mironiuc, Horațiu Silaghi, Ioana Delia Pop, Andra Diana Andreicuț
    Medicina.2019; 55(12): 757.     CrossRef
Editorial
Epidemiology
Diabetes Mellitus, Still Major Threat to Mortality from Various Causes
Nam Hoon Kim
Diabetes Metab J. 2019;43(3):273-275.   Published online June 13, 2019
DOI: https://doi.org/10.4093/dmj.2018.0102
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  • Classical and Novel Lipid-Lowering Therapies for Diabetic Patients with Established Coronary Artery Disease or High Risk of Coronary Artery Disease—A Narrative Clinical Review
    Nikolaos Velidakis, Panagiotis Stachteas, Evangelia Gkougkoudi, Christodoulos Papadopoulos, Nikolaos P. E. Kadoglou
    Pharmaceuticals.2024; 17(5): 568.     CrossRef
  • Analysis of Cause-of-Death Mortality in Children and Young Adults with Diabetes: A Nationwide 10-Year Follow-Up Cohort Study
    Iee-Ho Choi, Sang-Woo Yeom, Sun-Young Kim, Jihye You, Jong-Seung Kim, Minsun Kim
    Children.2023; 10(2): 358.     CrossRef
  • Improvement in Age at Mortality and Changes in Causes of Death in the Population with Diabetes: An Analysis of Data from the Korean National Health Insurance and Statistical Information Service, 2006 to 2018
    Eugene Han, Sun Ok Song, Hye Soon Kim, Kang Ju Son, Sun Ha Jee, Bong-Soo Cha, Byung-Wan Lee
    Endocrinology and Metabolism.2022; 37(3): 466.     CrossRef
  • An exhaustive perspective on structural insights of SGLT2 inhibitors: A novel class of antidiabetic agent
    Sushanta Bhattacharya, Akash Rathore, Deepa Parwani, Chaitali Mallick, Vivek Asati, Shivangi Agarwal, Vaibhav Rajoriya, Ratnesh Das, Sushil Kumar Kashaw
    European Journal of Medicinal Chemistry.2020; 204: 112523.     CrossRef
  • Increased Age of Death and Change in Causes of Death Among Persons With Diabetes Mellitus From the Korean National Health Insurance and Statistical Information Service, 2006 to 2018
    Eugene Han, Sun Ok Song, Hye Soon Kim, Kang Ju Son, Sun Ha Jee, Bong-Soo Cha, Byung-Wan Lee
    SSRN Electronic Journal .2020;[Epub]     CrossRef
Original Articles
Clinical Diabetes & Therapeutics
Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
Tae Jung Oh, Jae Myung Yu, Kyung Wan Min, Hyun Shik Son, Moon Kyu Lee, Kun Ho Yoon, Young Duk Song, Joong Yeol Park, In Kyung Jeong, Bong Soo Cha, Yong Seong Kim, Sei Hyun Baik, In Joo Kim, Doo Man Kim, Sung Rae Kim, Kwan Woo Lee, Jeong Hyung Park, In Kyu Lee, Tae Sun Park, Sung Hee Choi, Sung Woo Park
Diabetes Metab J. 2019;43(3):276-286.   Published online December 7, 2018
DOI: https://doi.org/10.4093/dmj.2018.0051
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AbstractAbstract PDFPubReader   
Background

Combination of metformin to reduce the fasting plasma glucose level and an α-glucosidase inhibitor to decrease the postprandial glucose level is expected to generate a complementary effect. We compared the efficacy and safety of a fixed-dose combination of voglibose plus metformin (vogmet) with metformin monotherapy in drug-naïve newly-diagnosed type 2 diabetes mellitus.

Methods

A total of 187 eligible patients aged 20 to 70 years, with a glycosylated hemoglobin (HbA1c) level of 7.0% to 11.0%, were randomized into either vogmet or metformin treatments for 24 weeks. A change in the HbA1c level from baseline was measured at week 24.

Results

The reduction in the levels of HbA1c was −1.62%±0.07% in the vogmet group and −1.31%±0.07% in the metformin group (P=0.003), and significantly more vogmet-treated patients achieved the target HbA1c levels of <6.5% (P=0.002) or <7% (P=0.039). Glycemic variability was also significantly improved with vogmet treatment, estimated by M-values (P=0.004). Gastrointestinal adverse events and hypoglycemia (%) were numerically lower in the vogmet-treated group. Moreover, a significant weight loss was observed with vogmet treatment compared with metformin (−1.63 kg vs. −0.86 kg, P=0.039).

Conclusion

Vogmet is a safe antihyperglycemic agent that controls blood glucose level effectively, yields weight loss, and is superior to metformin in terms of various key glycemic parameters without increasing the risk of hypoglycemia.

Citations

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  • Phytochemical analysis and antihyperglycemic activity of Castilleja arvensis
    Mónica Aideé Díaz-Román, Juan José Acevedo-Fernández, Gabriela Ávila-Villarreal, Elizabeth Negrete-León, A. Berenice Aguilar-Guadarrama
    Fitoterapia.2024; 174: 105839.     CrossRef
  • YAP/TAZ axis was involved in the effects of metformin on breast cancer
    Yu Xu, Hongke Cai, Yuanfeng Xiong, Li Tang, Longjiang Li, Li Zhang, Yi Shen, Yongqiang Yang, Ling Lin, Jiayi Huang
    Journal of Chemotherapy.2023; 35(7): 627.     CrossRef
  • Diabetes remission: Myth or reality?
    Ashok Kumar, ShubhaLaxmi Margekar, Ravi Kumar
    Indian Journal of Medical Specialities.2023; 14(1): 3.     CrossRef
  • Analysis of Reports Sent to the Portuguese Pharmacovigilance System and Published Literature Regarding the Safety of Metformin in the Elderly
    Beatriz Esteves, Cristina Monteiro, Ana Paula Coelho Duarte
    Healthcare.2023; 11(15): 2197.     CrossRef
  • Rapid prediction method of α-Glycosidase inhibitory activity of Coreopsis tinctoria extract from different habitats by near infrared spectroscopy
    Xiaogang He, Xiang Han, Jiaping Yu, Yulong Feng, Ganghui Chu
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.2022; 268: 120601.     CrossRef
  • Insulin autoimmune syndrome in patients with type 2 diabetes: A report of two cases
    Y. Shin, T.J. Oh, S.H. Choi, H.C. Jang
    Diabetes & Metabolism.2021; 47(1): 101115.     CrossRef
  • Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study
    Jun Sung Moon, Sunghwan Suh, Sang Soo Kim, Heung Yong Jin, Jeong Mi Kim, Min Hee Jang, Kyung Ae Lee, Ju Hyung Lee, Seung Min Chung, Young Sang Lyu, Jin Hwa Kim, Sang Yong Kim, Jung Eun Jang, Tae Nyun Kim, Sung Woo Kim, Eonju Jeon, Nan Hee Cho, Mi-Kyung Ki
    Diabetes & Metabolism Journal.2021; 45(5): 675.     CrossRef
  • Quantifying Remission Probability in Type 2 Diabetes Mellitus
    Sanjay Kalra, Ganapathi Bantwal, Nitin Kapoor, Rakesh Sahay, Saptarshi Bhattacharya, Beatrice Anne, Raju A Gopal, Sunil Kota, Ashok Kumar, Ameya Joshi, Debmalya Sanyal, Mangesh Tiwaskar, Ashok Kumar Das
    Clinics and Practice.2021; 11(4): 850.     CrossRef
  • The effect of voglibose on metabolic profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of clinical trials
    Peyman Nowrouzi-Sohrabi, Reza Tabrizi, Shahla Rezaei, Fatemeh Jafari, Kamran Hessami, Mehdi Abedi, Mohammad Jalali, Pedram Keshavarzi, Saeed Shahabi, Ali Asghar Kolahi, Kristin Carson-Chahhoud, Amirhossein Sahebkar, Saeid Safiri
    Pharmacological Research.2020; 159: 104988.     CrossRef
  • Role of Intestinal Microbiota in Metabolism of Voglibose In Vitro and In Vivo
    Mahesh Raj Nepal, Mi Jeong Kang, Geon Ho Kim, Dong Ho Cha, Ju-Hyun Kim, Tae Cheon Jeong
    Diabetes & Metabolism Journal.2020; 44(6): 908.     CrossRef
  • Response: Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial (Diabetes metab J 2019;43;276-86)
    Tae Jung Oh, Sung Hee Choi
    Diabetes & Metabolism Journal.2019; 43(4): 547.     CrossRef
  • Letter: Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial (Diabetes Metab J 2019;43;276-86)
    Hannah Seok, Tae Seo Sohn
    Diabetes & Metabolism Journal.2019; 43(4): 545.     CrossRef
Clinical Diabetes & Therapeutics
Acarbose Add-on Therapy in Patients with Type 2 Diabetes Mellitus with Metformin and Sitagliptin Failure: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study
Hae Kyung Yang, Seung-Hwan Lee, Juyoung Shin, Yoon-Hee Choi, Yu-Bae Ahn, Byung-Wan Lee, Eun Jung Rhee, Kyung Wan Min, Kun-Ho Yoon
Diabetes Metab J. 2019;43(3):287-301.   Published online December 20, 2018
DOI: https://doi.org/10.4093/dmj.2018.0054
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AbstractAbstract PDFSupplementary MaterialPubReader   
Background

We evaluated the efficacy and safety of acarbose add-on therapy in Korean patients with type 2 diabetes mellitus (T2DM) who are inadequately controlled with metformin and sitagliptin.

Methods

A total of 165 subjects were randomized to metformin and sitagliptin (Met+Sita, n=65), metformin, sitagliptin, and acarbose (Met+Sita+Acarb, n=66) and sitagliptin and acarbose (Sita+Acarb, exploratory assessment, n=34) therapy in five institutions in Korea. After 16 weeks of acarbose add-on or metformin-switch therapy, a triple combination therapy was maintained from week 16 to 24.

Results

The add-on of acarbose (Met+Sita+Acarb group) demonstrated a 0.44%±0.08% (P<0.001 vs. baseline) decrease in glycosylated hemoglobin (HbA1c) at week 16, while changes in HbA1c were insignificant in the Met+Sita group (−0.09%±0.10%, P=0.113). After 8 weeks of triple combination therapy, HbA1c levels were comparable between Met+Sita and Met+Sita+Acarb group (7.66%±0.13% vs. 7.47%±0.12%, P=0.321). Acarbose add-on therapy demonstrated suppressed glucagon secretion (area under the curve of glucagon, 4,726.17±415.80 ng·min/L vs. 3,314.38±191.63 ng·min/L, P=0.004) in the absence of excess insulin secretion during the meal tolerance tests at week 16 versus baseline. The incidence of adverse or serious adverse events was similar between two groups.

Conclusion

In conclusion, a 16-week acarbose add-on therapy to metformin and sitagliptin, effectively lowered HbA1c without significant adverse events. Acarbose might be a good choice as a third-line therapy in addition to metformin and sitagliptin in Korean subjects with T2DM who have predominant postprandial hyperglycemia and a high carbohydrate intake.

Citations

Citations to this article as recorded by  
  • The effect of acarbose on inflammatory cytokines and adipokines in adults: a systematic review and meta-analysis of randomized clinical trials
    Ali Mohammadian, Sahand Tehrani Fateh, Mahlagha Nikbaf-Shandiz, Fatemeh Gholami, Niloufar Rasaei, Hossein Bahari, Samira Rastgoo, Reza Bagheri, Farideh Shiraseb, Omid Asbaghi
    Inflammopharmacology.2024;[Epub]     CrossRef
  • An Update on Dipeptidyl Peptidase-IV Inhibiting Peptides
    Sachithanantham Annapoorani Sivaraman, Varatharajan Sabareesh
    Current Protein & Peptide Science.2024; 25(4): 267.     CrossRef
  • Deciphering Molecular Aspects of Potential α-Glucosidase Inhibitors within Aspergillus terreus: A Computational Odyssey of Molecular Docking-Coupled Dynamics Simulations and Pharmacokinetic Profiling
    Sameh S. Elhady, Noha M. Alshobaki, Mahmoud A. Elfaky, Abdulrahman E. Koshak, Majed Alharbi, Reda F. A. Abdelhameed, Khaled M. Darwish
    Metabolites.2023; 13(8): 942.     CrossRef
  • Change of metformin concentrations in the liver as a pharmacological target site of metformin after long-term combined treatment with ginseng berry extract
    Choong Whan Lee, Byoung Hoon You, Sreymom Yim, Seung Yon Han, Hee-Sung Chae, Mingoo Bae, Seo-Yeon Kim, Jeong-Eun Yu, Jieun Jung, Piseth Nhoek, Hojun Kim, Han Seok Choi, Young-Won Chin, Hyun Woo Kim, Young Hee Choi
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • A Comprehensive Review on Weight Loss Associated with Anti-Diabetic Medications
    Fatma Haddad, Ghadeer Dokmak, Maryam Bader, Rafik Karaman
    Life.2023; 13(4): 1012.     CrossRef
  • The effects of acarbose treatment on cardiovascular risk factors in impaired glucose tolerance and diabetic patients: a systematic review and dose–response meta-analysis of randomized clinical trials
    Mohammad Zamani, Mahlagha Nikbaf-Shandiz, Yasaman Aali, Niloufar Rasaei, Mahtab Zarei, Farideh Shiraseb, Omid Asbaghi
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • The effect of acarbose on lipid profiles in adults: a systematic review and meta-analysis of randomized clinical trials
    Mohsen Yousefi, Sahand Tehrani Fateh, Mahlagha Nikbaf-Shandiz, Fatemeh Gholami, Samira Rastgoo, Reza Bagher, Alireza Khadem, Farideh Shiraseb, Omid Asbaghi
    BMC Pharmacology and Toxicology.2023;[Epub]     CrossRef
  • A systematic review, meta-analysis, dose-response, and meta-regression of the effects of acarbose intake on glycemic markers in adults
    Sina Raissi Dehkordi, Naseh Pahlavani, Mahlagha Nikbaf-Shandiz, Reza Bagheri, Niloufar Rasaei, Melika Darzi, Samira Rastgoo, Hossein Bahari, Farideh Shiraseb, Omid Asbaghi
    Journal of Diabetes & Metabolic Disorders.2023;[Epub]     CrossRef
  • Inhibitory activity of xanthoangelol isolated from Ashitaba (Angelica keiskei Koidzumi) towards α-glucosidase and dipeptidyl peptidase-IV: in silico and in vitro studies
    Diah Lia Aulifa, I Ketut Adnyana, Sukrasno Sukrasno, Jutti Levita
    Heliyon.2022; 8(5): e09501.     CrossRef
  • Design, synthesis, and in silico studies of benzimidazole bearing phenoxyacetamide derivatives as α-glucosidase and α-amylase inhibitors
    Nahal Shayegan, Aida Iraji, Nasim Bakhshi, Ali Moazzam, Mohammad Ali Faramarzi, Somayeh Mojtabavi, Seyyed Mehrdad Mostafavi Pour, Maliheh Barazandeh Tehrani, Bagher Larijani, Zahra Rezaei, Pardis Yousefi, Mehdi Khoshneviszadeh, Mohammad Mahdavi
    Journal of Molecular Structure.2022; 1268: 133650.     CrossRef
  • American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan—2022 Update
    Lawrence Blonde, Guillermo E. Umpierrez, S. Sethu Reddy, Janet B. McGill, Sarah L. Berga, Michael Bush, Suchitra Chandrasekaran, Ralph A. DeFronzo, Daniel Einhorn, Rodolfo J. Galindo, Thomas W. Gardner, Rajesh Garg, W. Timothy Garvey, Irl B. Hirsch, Danie
    Endocrine Practice.2022; 28(10): 923.     CrossRef
  • Combination of Bawang Dayak Extract and Acarbose against Male White Rat Glucose Levels
    Aditya Maulana Perdana Putra, Ratih Pratiwi Sari, Siska Musiam
    Borneo Journal of Pharmacy.2021; 4(2): 84.     CrossRef
  • Natural α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors: A Source of Scaffold Molecules for Synthesis of New Multitarget Antidiabetic Drugs
    Massimo Genovese, Ilaria Nesi, Anna Caselli, Paolo Paoli
    Molecules.2021; 26(16): 4818.     CrossRef
  • Impact of Simulated Gastrointestinal Conditions on Antiglycoxidant and α-Glucosidase Inhibition Capacities of Cyanidin-3-O-Glucoside
    Didier Fraisse, Alexis Bred, Catherine Felgines, François Senejoux
    Antioxidants.2021; 10(11): 1670.     CrossRef
Clinical Diabetes & Therapeutics
Effectiveness of Exercise Intervention in Reducing Body Weight and Glycosylated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus in Korea: A Systematic Review and Meta-Analysis
Ji-Eun Jang, Yongin Cho, Byung Wan Lee, Ein-Soon Shin, Sun Hee Lee
Diabetes Metab J. 2019;43(3):302-318.   Published online November 19, 2018
DOI: https://doi.org/10.4093/dmj.2018.0062
  • 5,629 View
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AbstractAbstract PDFSupplementary MaterialPubReader   
Background

This study aimed to assess the effectiveness of exercise intervention in reducing body weight and glycosylated hemoglobin (HbA1c) level in patients with type 2 diabetes mellitus (T2DM) in Korea.

Methods

Cochrane, PubMed, Embase, KoreaMed, KMbase, NDSL, KCI, RISS, and DBpia databases were used to search randomized controlled trials and controlled clinical trials that compared exercise with non-exercise intervention among patients with non-insulin-treated T2DM in Korea. The effectiveness of exercise intervention was estimated by the mean difference in body weight changes and HbA1c level. Weighted mean difference (WMD) with its corresponding 95% confidence interval (CI) was used as the effect size. The pooled mean differences of outcomes were calculated using a random-effects model.

Results

We identified 7,692 studies through literature search and selected 23 articles (723 participants). Compared with the control group, exercise intervention (17 studies) was associated with a significant decline in HbA1c level (WMD, −0.58%; 95% CI, −0.89 to −0.27; I2=73%). Although no significant effectiveness on body weight was observed, eight aerobic training studies showed a significant reduction in body weight (WMD, −2.25 kg; 95% CI, −4.36 to −0.13; I2=17%) in the subgroup analysis.

Conclusion

Exercise significantly improves glycemic control; however, it does not significantly reduce body weight. Aerobic training can be beneficial for patients with non-insulin-treated T2DM in Korea.

Citations

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  • Effect of low-volume combined aerobic and resistance high-intensity interval training on vascular health in people with type 2 diabetes: a randomised controlled trial
    Emily R. Cox, Trishan Gajanand, Shelley E. Keating, Matthew D. Hordern, Nicola W. Burton, Daniel J. Green, Joyce S. Ramos, Maximiano V. Ramos, Robert G. Fassett, Stephen V. Cox, Jeff S. Coombes, Tom G. Bailey
    European Journal of Applied Physiology.2024;[Epub]     CrossRef
  • The anti-inflammatory effects of aerobic exercise training in patients with type 2 diabetes: A systematic review and meta-analysis
    Georgia Papagianni, Chrystalla Panayiotou, Michail Vardas, Nikolaos Balaskas, Constantinos Antonopoulos, Dimitrios Tachmatzidis, Triantafyllos Didangelos, Vaia Lambadiari, Nikolaos P.E. Kadoglou
    Cytokine.2023; 164: 156157.     CrossRef
  • Glucose Control in Korean Patients with Type 2 Diabetes Mellitus according to Body Mass Index
    Ye-lim Shin, Heesoh Yoo, Joo Young Hong, Jooeun Kim, Kyung-do Han, Kyu-Na Lee, Yang-Hyun Kim
    Journal of Obesity & Metabolic Syndrome.2023; 32(1): 55.     CrossRef
  • Exercise therapy for diabetes mellitus
    Chaiho Jeong, Tae-Seo Sohn
    Journal of the Korean Medical Association.2023; 66(7): 427.     CrossRef
  • Effects of an evidence‐based nursing intervention on prevention of anxiety and depression in the postpartum period
    Jun Meng, Junying Du, Xiaoli Diao, Yingxia Zou
    Stress and Health.2022; 38(3): 435.     CrossRef
  • Effect of exercise intervention dosage on reducing visceral adipose tissue: a systematic review and network meta-analysis of randomized controlled trials
    Yu-Hsuan Chang, Hui-Ying Yang, Shiow-Ching Shun
    International Journal of Obesity.2021; 45(5): 982.     CrossRef
  • Development and validation of the type 2 diabetes mellitus 10-year risk score prediction models from survey data
    Gregor Stiglic, Fei Wang, Aziz Sheikh, Leona Cilar
    Primary Care Diabetes.2021; 15(4): 699.     CrossRef
  • Pioglitazone for NAFLD Patients With Prediabetes or Type 2 Diabetes Mellitus: A Meta-Analysis
    Jingxuan Lian, Jianfang Fu
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Exercise Training: The Holistic Approach in Cardiovascular Prevention
    Francesco Giallauria, Teresa Strisciuglio, Gianluigi Cuomo, Anna Di Lorenzo, Andrea D’Angelo, Mario Volpicelli, Raffaele Izzo, Maria Virginia Manzi, Emanuele Barbato, Carmine Morisco
    High Blood Pressure & Cardiovascular Prevention.2021; 28(6): 561.     CrossRef
  • Effect of chronic High Intensity Interval Training on glycosylated haemoglobin in people with type 2 diabetes: a meta-analysis
    María Cristina Arrieta-Leandro, Jessenia Hernández-Elizondo, Judith Jiménez-Díaz
    Human Movement.2021; 24(1): 32.     CrossRef
  • Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association
    Byung-Wan Lee, Yong-ho Lee, Cheol-Young Park, Eun-Jung Rhee, Won-Young Lee, Nan-Hee Kim, Kyung Mook Choi, Keun-Gyu Park, Yeon-Kyung Choi, Bong-Soo Cha, Dae Ho Lee
    Diabetes & Metabolism Journal.2020; 44(3): 382.     CrossRef
  • Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease
    Kyung-Soo Kim, Byung-Wan Lee
    Clinical and Molecular Hepatology.2020; 26(4): 430.     CrossRef
  • Factors Influencing Glycemic Control among Type 2 Diabetes Mellitus Patients: The Sixth Korea National Health and Nutrition Examination Survey (2013~2015)
    Mee Ock Gu
    Korean Journal of Adult Nursing.2019; 31(3): 235.     CrossRef
Epidemiology
Diabetes Mellitus and Cause-Specific Mortality: A Population-Based Study
Sen Li, Jiaxin Wang, Biao Zhang, Xinyi Li, Yuan Liu
Diabetes Metab J. 2019;43(3):319-341.   Published online April 19, 2019
DOI: https://doi.org/10.4093/dmj.2018.0060
  • 20,807 View
  • 261 Download
  • 128 Web of Science
  • 140 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

To investigate whether diabetes contributes to mortality for major types of diseases.

Methods

Six National Health and Nutrition Examination Survey data cycles (1999 to 2000, 2001 to 2002, 2003 to 2004, 2005 to 2006, 2007 to 2008, and 2009 to 2010) and their linked mortality files were used. A population of 15,513 participants was included according to the availability of diabetes and mortality status.

Results

Participants with diabetes tended to have higher all-cause mortality and mortality due to cardiovascular disease, cancer, chronic lower respiratory diseases, cerebrovascular disease, influenza and pneumonia, and kidney disease. Confounder-adjusted Cox proportional hazard models showed that both diagnosed diabetes category (yes or no) and diabetes status (diabetes, prediabetes, or no diabetes) were associated with all-cause mortality and with mortality due to cardiovascular disease, chronic lower respiratory diseases, influenza and pneumonia, and kidney disease. No associations were found for cancer-, accidents-, or Alzheimer's disease-related mortality.

Conclusion

The current study's findings provide epidemiological evidence that diagnosed diabetes at the baseline is associated with increased mortality risk due to cardiovascular disease, chronic lower respiratory diseases, influenza and pneumonia, and kidney disease, but not with cancer or Alzheimer's disease.

Citations

Citations to this article as recorded by  
  • Association of type 2 diabetes mellitus with dementia‐related and non–dementia‐related mortality among postmenopausal women: A secondary competing risks analysis of the women's health initiative
    Tyler J. Titcomb, Phyllis Richey, Ramon Casanova, Lawrence S. Phillips, Simin Liu, Shama D. Karanth, Nazmus Saquib, Tomas Nuño, JoAnn E. Manson, Aladdin H. Shadyab, Longjian Liu, Terry L. Wahls, Linda G. Snetselaar, Robert B. Wallace, Wei Bao
    Alzheimer's & Dementia.2024; 20(1): 234.     CrossRef
  • Antiglycation potential of metal ions and polyphenolic extract of chickpea on thiol-protease inhibitor: A management for diabetic complications
    Mohd Shahnawaz Khan, Sheraz Ahmad Bhat, Monnera Saud Albagmi, Mohammed Arshad, Mohammad Tarique, Bilqees Bano
    Saudi Pharmaceutical Journal.2024; 32(1): 101916.     CrossRef
  • GLP-1 receptor agonists, SGLT2 inhibitors and noncardiovascular mortality in type 2 diabetes: Insights from a meta-analysis
    Mainak Banerjee, Rimesh Pal, Indira Maisnam, Satinath Mukhopadhyay
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2024; 18(1): 102943.     CrossRef
  • Assessment of the radial peripapillary capillary plexus and retinal nerve fiber layer thickness in diabetic patients in comparison to normal age-matched individuals
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    Journal of the Egyptian Ophthalmological Society.2024; 117(1): 43.     CrossRef
  • Fasting GLP-1 Levels and Albuminuria Are Negatively Associated in Patients with Type 2 Diabetes Mellitus
    Cheol-Won Jang, Tae Yang Yu, Jin Woo Jeong, Se Eun Ha, Rajan Singh, Moon Young Lee, Seungil Ro
    Journal of Personalized Medicine.2024; 14(3): 280.     CrossRef
  • The Benefits and Harms of Lung Cancer Screening in Individuals With Comorbidities
    Minal S. Kale, Keith Sigel, Arushi Arora, Bart S. Ferket, Juan Wisnivesky, Chung Yin Kong
    JTO Clinical and Research Reports.2024; 5(3): 100635.     CrossRef
  • Risk factor control and cardiovascular events in patients with type 2 diabetes mellitus
    Do Kyeong Song, Young Sun Hong, Yeon-Ah Sung, Hyejin Lee, Hidetaka Hamasaki
    PLOS ONE.2024; 19(2): e0299035.     CrossRef
  • Liraglutide Attenuates Diabetic Cardiomyopathy via the ILK/PI3K/AKT/PTEN Signaling Pathway in Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus
    Shatha M. Alobaid, Rahaf M. Alshahrani, Asma S. Alonazi, Nawal M. Alrasheed, Maha A. Alamin, Tahani K. Alshammari, Anfal F. Bin Dayel, Doaa M. Elnagar, Rana R. Alotaibi, Lama A. Almuthnabi, Dalia H. Almasud, Shahad E. Al-Ammar, Shahad O. Almadhi, Reema A.
    Pharmaceuticals.2024; 17(3): 374.     CrossRef
  • Effects of high-intensity interval training and its different protocols on lipid profile and glycaemic control in type 2 diabetes: A meta-analysis
    Nandiny Paula Cavalli, Mariana Brondani de Mello, Natiele Camponogara Righi, Felipe Barreto Schuch, Luis Ulisses Signori, Antônio Marcos Vargas da Silva
    Journal of Sports Sciences.2024; 42(4): 333.     CrossRef
  • Role of renin-angiotensin system/angiotensin converting enzyme-2 mechanism and enhanced COVID-19 susceptibility in type 2 diabetes mellitus
    Ashwin Kumar Shukla, Komal Awasthi, Kauser Usman, Monisha Banerjee
    World Journal of Diabetes.2024; 15(4): 606.     CrossRef
  • Precision Medicine in Bariatric Procedures
    Khushboo Gala, Wissam Ghusn, Andres Acosta
    Gastrointestinal Endoscopy Clinics of North America.2024;[Epub]     CrossRef
  • Gamma‐glutamyl transferase and the risk of all‐cause and disease‐specific mortality in patients with diabetes: A nationwide cohort study
    Goh Eun Chung, Su‐Min Jeong, Su Jong Yu, Jeong‐Ju Yoo, Yuri Cho, Kyu‐na Lee, Dong Wook Shin, Yoon Jun Kim, Jung‐Hwan Yoon, Kyungdo Han, Eun Ju Cho
    Journal of Diabetes.2024;[Epub]     CrossRef
  • Trends in cause-specific mortality among people with type 2 and type 1 diabetes from 2002 to 2019: a Danish population-based study
    Tinne Laurberg, Susanne B. Graversen, Annelli Sandbæk, Sarah H. Wild, Rimke C. Vos, Henrik Støvring
    The Lancet Regional Health - Europe.2024; 41: 100909.     CrossRef
  • Behavioral Therapy for People With Diabetes Who Smoke: A Scoping Review
    Roberta Sammut, Joseph Grech, Riccardo Polosa, Davide Campagna, Agostino Di Ciaula, Tabinda Dugal, Andre Kenge, Anoop Misra, Syed Abbas Raza, Cristina Russo, Noel Somasundaram, Magdalena Walicka, Le Dinh Phoung, Graziella Chiara Prezzavento, Mirko Casu, G
    Journal of Primary Care & Community Health.2024;[Epub]     CrossRef
  • Inhibition of sodium-glucose cotransporter-2 and liver-related complications in individuals with diabetes: a Mendelian randomization and population-based cohort study
    Sung Won Chung, Hye-Sung Moon, Hyunjae Shin, Hyein Han, Sehoon Park, Heejin Cho, Jeayeon Park, Moon Haeng Hur, Min Kyung Park, Sung-Ho Won, Yun Bin Lee, Eun Ju Cho, Su Jong Yu, Dong Ki Kim, Jung-Hwan Yoon, Jeong-Hoon Lee, Yoon Jun Kim
    Hepatology.2024;[Epub]     CrossRef
  • The Incidence of Type 2 Diabetes Mellitus and Weight Gain in People Living with HIV Receiving a Dolutegravir-Based Antiretroviral Therapy in Addis Ababa, Ethiopia: A Pilot Single-Arm Historical Cohort Study
    Tariku Shimels, Arebu Issa Bilal, Desta Samuel, Desalew Gedamu, Eden Solomon, Zewdneh Shewamene
    Venereology.2024; 3(2): 96.     CrossRef
  • Nerolidol Alleviates Oxidative Stress and Inflammation in Diabetic Retinopathy 
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    Pharmacognosy Magazine.2024;[Epub]     CrossRef
  • Low-carbohydrate diet for people with type 2 diabetes mellitus
    Mariana Andrea Burgos, Diego Ivaldi, Gisela Oltra, Camila Micaela Escobar Liquitay, Luis Garegnani
    Cochrane Database of Systematic Reviews.2024;[Epub]     CrossRef
  • Impact of integrative care on cardiovascular disease risk in newly diagnosed type 2 diabetes mellitus patients: A BI-VitalLife Cohort study
    Tanawat Khunlertkit, Teeradache Viangteeravat, Panupong Wangprapa, Suthee Siriwechdaruk, Jeremy Mark Ford, Krit Pongpirul, Amirmohammad Khalaji
    PLOS ONE.2024; 19(5): e0302438.     CrossRef
  • Comparison between in-person, telehealth, and combination visits among veterans treated in a pharmacist-led diabetes management clinic
    Olivia Yip, Evon Du, Candis M. Morello, Mark Bounthavong
    Journal of the American Pharmacists Association.2024; 64(4): 102121.     CrossRef
  • Design of the DAVOS Study: Diabetes Smartphone App, a Fully Automatic Transmission of Data From the Blood Glucose Meter and Insulin Pens Using Wireless Technology to Enhance Diabetes Self-Management—A Study Protocol for a Randomized Controlled Trial
    Franziska Grosser, Sandra Herrmann, Maxi Bretschneider, Patrick Timpel, Janko Schildt, Markus Bentrup, Peter E. H. Schwarz
    Journal of Diabetes Science and Technology.2023; 17(3): 742.     CrossRef
  • Low diet quality is associated with adverse levels of metabolic health markers and clustering of risk factors in adults with type 2 diabetes
    Namrata Sanjeevi, Jeanne H. Freeland‐Graves
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  • Need for improving immunization status and preventive care in diabetes mellitus patients
    Teresa Gisinger, Alexandra Kautzky-Willer, Michael Leutner
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    Journal of Drug Delivery Science and Technology.2023; 79: 104003.     CrossRef
  • Significant Association between Subclinical Left Cardiac Dysfunction and Liver Stiffness in Metabolic Syndrome Patients with Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease
    Alexandru Apostu, Daniel Malita, Sergiu-Florin Arnautu, Mirela-Cleopatra Tomescu, Dan Gaiță, Alina Popescu, Ruxandra Mare, Ramona Gidea, Diana-Aurora Arnautu
    Medicina.2023; 59(2): 328.     CrossRef
  • An examination of causal associations and shared risk factors for diabetes and cardiovascular diseases in the East Asian population: A Mendelian randomization study
    Yulin Guo, Jie Gao, Yan Liu, Yanxiong Jia, Xiangguang An, Xitao Zhang, Pixiong Su
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Synthesis, Cytotoxicity and In Vitro α-Glucosidase Inhibition of New N-Substituted Glitazone and Rhodanine Derivatives
    N. R. Tshiluka, M. V. Bvumbi, S. S. Mnyakeni-Moleele
    Russian Journal of Bioorganic Chemistry.2023; 49(2): 384.     CrossRef
  • Prevalence of QT prolongation and its risk factors in patients with type 2 diabetes
    Khaled Aburisheh, Mohammad F. AlKheraiji, Saleh I. Alwalan, Arthur C. Isnani, Mohamed Rafiullah, Muhammad Mujammami, Assim A. Alfadda
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • Adapted Diabetes Complications Severity Index and Charlson Comorbidity Index in predicting all-cause and cause-specific mortality among patients with type 2 diabetes
    Yu-Wen Hu, Chiu-Mei Yeh, Chia-Jen Liu, Tzeng-Ji Chen, Nicole Huang, Yiing-Jenq Chou
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    Journal of Clinical Medicine.2023; 12(13): 4489.     CrossRef
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  • Increased Left Atrial Stiffness is Significantly Associated with Paroxysmal Atrial Fibrillation in Diabetic Patients
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    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 2077.     CrossRef
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  • Diabetes associates with mortality in critically ill patients with SARS-CoV-2 pneumonia: No diabetes paradox in COVID-19
    Priscila Bellaver, Larissa Schneider, Ariell F. Schaeffer, Lilian Rodrigues Henrique, Joíza Lins Camargo, Fernando Gerchman, Cristiane B. Leitão, Tatiana H. Rech
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  • New Insights into the Role of Oxidative Stress in the Development of Diabetes Mellitus and Its Complications
    Julia Matzenbacher dos Santos, Qing Zhong, Sandra A. Benite-Ribeiro, Thiago Gomes Heck
    Journal of Diabetes Research.2023; 2023: 1.     CrossRef
  • A paradigm shift for cardiovascular outcome evaluation in diabetes: Major adverse cardiovascular events (MACE) to major adverse vascular events (MAVE)
    Ashu Rastogi, Anand Sudhayakumar, Nicolaas C. Schaper, Edward B. Jude
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(11): 102875.     CrossRef
  • Assessing Elevated Blood Glucose Levels Through Blood Glucose Evaluation and Monitoring Using Machine Learning and Wearable Photoplethysmography Sensors: Algorithm Development and Validation
    Bohan Shi, Satvinder Singh Dhaliwal, Marcus Soo, Cheri Chan, Jocelin Wong, Natalie W C Lam, Entong Zhou, Vivien Paitimusa, Kum Yin Loke, Joel Chin, Mei Tuan Chua, Kathy Chiew Suan Liaw, Amos W H Lim, Fadil Fatin Insyirah, Shih-Cheng Yen, Arthur Tay, Seng
    JMIR AI.2023; 2: e48340.     CrossRef
  • Cost-Utility of an Exercise Referral Scheme Versus Doing Nothing in Flemish Adults: Exploring the Impact of Key Assumptions
    Amber Werbrouck, Masja Schmidt, Koen Putman, Steven Simoens, Nick Verhaeghe, Lieven Annemans
    Journal of Physical Activity and Health.2023; : 1.     CrossRef
  • Community-based models of care for management of type 2 diabetes mellitus among non-pregnant adults in sub-Saharan Africa: A scoping review
    Emmanuel Firima, Lucia Gonzalez, Fabiola Ursprung, Elena Robinson, Jacqueline Huber, Jennifer M. Belus, Fabian Raeber, Ravi Gupta, Gibrilla F. Deen, Alain Amstutz, Bailah Leigh, Maja Weisser, Niklaus Daniel Labhardt, Rehana Abdus Salam
    PLOS ONE.2023; 18(11): e0278353.     CrossRef
  • Omega-3 supplementation and diabetes: A systematic review and meta-analysis
    Felipe Mendes Delpino, Lílian Munhoz Figueiredo, Bruna Gonçalves Cordeiro da Silva, Taiciane Gonçalves da Silva, Gicele Costa Mintem, Renata Moraes Bielemann, Denise Petrucci Gigante
    Critical Reviews in Food Science and Nutrition.2022; 62(16): 4435.     CrossRef
  • The effect of real‐time monitoring of physical activity intensity in diabetic patients
    Rumi Tanaka, Kimie Fujita, Satoko Maeno, Kanako Yakushiji, Satomi Tanaka, Keizo Ohnaka, Kenji Ashida, Shohei Sakamoto, Masatoshi Nomura
    Japan Journal of Nursing Science.2022;[Epub]     CrossRef
  • Factors associated with influenza vaccine coverage among patients with diabetes: Korea National Health and Nutrition Examination Survey 2016–2018
    A. Lum Han
    International Journal of Diabetes in Developing Countries.2022; 42(2): 297.     CrossRef
  • Interacción entre el estadio de la enfermedad renal crónica y la diabetes mellitus como factores asociados con mortalidad en pacientes con enfermedad renal crónica: un estudio de cohortes externas
    Laura E. Villegas Sierra, Melisa Buriticá Agudelo, Carlos Enrique Yepes Delgado, Yanett Marcela Montoya Jaramillo, Fabián Jaimes Barragan
    Nefrología.2022; 42(5): 540.     CrossRef
  • Influence of glucose supplementation on biofilm formation of Candida albicans and Candida glabrata isolated from diabetic and non-diabetic individuals
    Pedro Castania Amadio Domingues, Viviane de Cássia Oliveira, Felipe Lazarini Bim, Carolina Patrícia Aires, André Pereira dos Santos, Denise Tornavoi de Castro, Cláudia Helena Silva-Lovato, Denise de Andrade, Evandro Watanabe
    Archives of Oral Biology.2022; 134: 105339.     CrossRef
  • The influence of the disclosure of diabetes on the cognitive, physical ability and diabetes self‐management in diabetic employed adults in Saudi Arabia
    Sitah Alshutwi, Eman Miligi, Lujain Alhumidan, Adel F. Almutairi
    Nursing Open.2022; 9(2): 978.     CrossRef
  • Effect of fermented cassava tuber on the gene expression of PI3K/Akt signaling and AMPK pathway in STZ-NA-induced diabetic rats
    Rio Jati Kusuma, Desty Ervira Puspaningtyas, Puspita Mardika Sari
    Nutrition & Food Science .2022; 52(2): 213.     CrossRef
  • A fractional order control model for Diabetes and COVID-19 co-dynamics with Mittag-Leffler function
    Andrew Omame, Ugochukwu K. Nwajeri, M. Abbas, Chibueze P. Onyenegecha
    Alexandria Engineering Journal.2022; 61(10): 7619.     CrossRef
  • Enhancing Choices Regarding the Administration of Insulin Among Patients With Diabetes Requiring Insulin Across Countries and Implications for Future Care
    Ileana Mardare, Stephen M. Campbell, Johanna C. Meyer, Israel Abebrese Sefah, Amos Massele, Brian Godman
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Dyslipidemia Among Patients With Type 1 Diabetes and Its Associated Factors in Saudi Arabia: An Analytical Cross-Sectional Study
    Abdullah A Alrasheed
    Cureus.2022;[Epub]     CrossRef
  • Prickly Pear Cacti (Opuntia spp.) Cladodes as a Functional Ingredient for Hyperglycemia Management: A Brief Narrative Review
    Rao Raahim Kashif, Nathan M. D’Cunha, Duane D. Mellor, Natalie I. Alexopoulos, Domenico Sergi, Nenad Naumovski
    Medicina.2022; 58(2): 300.     CrossRef
  • Machine learning for predicting chronic diseases: a systematic review
    F.M. Delpino, Â.K. Costa, S.R. Farias, A.D.P. Chiavegatto Filho, R.A. Arcêncio, B.P. Nunes
    Public Health.2022; 205: 14.     CrossRef
  • Effects of blueberry and cranberry on type 2 diabetes parameters in individuals with or without diabetes: A systematic review and meta-analysis of randomized clinical trials
    Felipe Mendes Delpino, Lílian Munhoz Figueiredo, Taiciane Gonçalves da Silva, Thaynã Ramos Flores
    Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(5): 1093.     CrossRef
  • Momordica charantia nanoparticles potentiate insulin release and modulate antioxidant gene expression in pancreas of diabetic rats
    Olusola Olalekan Elekofehinti
    Egyptian Journal of Medical Human Genetics.2022;[Epub]     CrossRef
  • GLP-1 receptor agonists in diabetic kidney disease: current evidence and future directions
    Ji Hee Yu, So Young Park, Da Young Lee, Nan Hee Kim, Ji A Seo
    Kidney Research and Clinical Practice.2022; 41(2): 136.     CrossRef
  • Pharmacological Study: Synergistic Antidiabetic Activity of Cinnamon Bark and Zingiber Extract in Streptozotocin-Induced Diabetic Rats
    Eva Nurinda, Nurul Kusumawardani, Ari Susiana Wulandari , Annisa Fatmawati, E. Emelda, Husnatun Nisa, Nurjani A. Hasan, Wahyu Fajar Iriyanti, Mardiatun Rohmah, Puji Lestari, Veriani Aprilia
    Open Access Macedonian Journal of Medical Sciences.2022; 10(T8): 1.     CrossRef
  • Integrating a Polygenic Risk Score for Coronary Artery Disease as a Risk‐Enhancing Factor in the Pooled Cohort Equation: A Cost‐Effectiveness Analysis Study
    Deo Mujwara, Geoffrey Henno, Stephen T. Vernon, Siyang Peng, Paolo Di Domenico, Brock Schroeder, George B. Busby, Gemma A Figtree, Giordano Bottà
    Journal of the American Heart Association.2022;[Epub]     CrossRef
  • Comparison of mechanistic pathways of bariatric surgery in patients with diabetes mellitus: A Bayesian network meta‐analysis
    Chaoxing Lin, Trevor James Jun‐Ming Yeong, Wen Hui Lim, Cheng Han Ng, Chun En Yau, Yip Han Chin, Mark D. Muthiah, Poay Huan Loh, Roger S. Y. Foo, Shao Feng Mok, Asim Shabbir, Georgios K. Dimitriadis, Chin Meng Khoo, Nicholas W. S. Chew
    Obesity.2022; 30(7): 1380.     CrossRef
  • Diabetes and COVID-19: Biological profile of type 2 diabetic patients with COVID-19 in Pointe-Noire, Congo
    Anicet Boumba Luc Magloire, Batchy Aladin Atandi, Elenga-Bongo Charley, Pouki Freddy Saturnin, Kibouilou Fredy, Balanda Christ Nkouanga, Dabo Tidiane Cheick Ahmed, Wahar Saar Abdoul, Mahouanga Didel Mampassi, Voumbi Ghislain Loubano, Moukassa Donatien
    Global Journal of Clinical Virology.2022; 7(1): 001.     CrossRef
  • Integrated Nutritional Supports for Diabetic Patients During COVID-19 Infection: A Comprehensive Review
    A.K. Obidul Huq, Abu Naim Mohammad Bazlur Rahim, S.M. Golam Moktadir, Ielias Uddin, Mohammad Zahidul Manir, Muhammad Abu Bakr Siddique, Khaleda Islam, Md. Sirajul Islam
    Current Diabetes Reviews.2022;[Epub]     CrossRef
  • Mechanisms of COVID-19 pathogenesis in diabetes
    Chandrakala Aluganti Narasimhulu, Dinender K. Singla
    American Journal of Physiology-Heart and Circulatory Physiology.2022; 323(3): H403.     CrossRef
  • Improvement in Age at Mortality and Changes in Causes of Death in the Population with Diabetes: An Analysis of Data from the Korean National Health Insurance and Statistical Information Service, 2006 to 2018
    Eugene Han, Sun Ok Song, Hye Soon Kim, Kang Ju Son, Sun Ha Jee, Bong-Soo Cha, Byung-Wan Lee
    Endocrinology and Metabolism.2022; 37(3): 466.     CrossRef
  • Gender difference in association between diabetes mellitus and all-cause mortality in atrial fibrillation patients
    Li Tian, Yan-min Yang, Jun Zhu, Han Zhang, Xing-hui Shao
    Journal of Diabetes and its Complications.2022; 36(9): 108265.     CrossRef
  • An Overview of Diabetes Mellitus in Egypt and the Significance of Integrating Preventive Cardiology in Diabetes Management
    Mohamed R Abouzid, Karim Ali, Ibrahim Elkhawas, Shorouk M Elshafei
    Cureus.2022;[Epub]     CrossRef
  • The association between diabetes mellitus and functionality in knee osteoarthritis: a cross-sectional study
    Serdar KAYMAZ, Sanem Aslıhan AYKAN
    Journal of Health Sciences and Medicine.2022; 5(4): 1114.     CrossRef
  • In-hospital hyperglycemia but not diabetes mellitus alone is associated with increased in-hospital mortality in community-acquired pneumonia (CAP): a systematic review and meta-analysis of observational studies prior to COVID-19
    Rahul D Barmanray, Nathan Cheuk, Spiros Fourlanos, Peter B Greenberg, Peter G Colman, Leon J Worth
    BMJ Open Diabetes Research & Care.2022; 10(4): e002880.     CrossRef
  • The association between leukocyte telomere length and chronic obstructive pulmonary disease is partially mediated by inflammation: a meta-analysis and population-based mediation study
    Tieshan Wang, Zhaoqi Jia, Sen Li, Yuxin Li, Tingting Yu, Tao Lu, Yuanyuan Shi
    BMC Pulmonary Medicine.2022;[Epub]     CrossRef
  • The Influence of Diabetic Peripheral Neuropathy on the Duration of Sciatic Nerve Block with 1.3% Liposomal Bupivacaine and 0.25% Bupivacaine Hydrochloride in a Mouse Model
    Liljana Markova, Erika Cvetko, Chiedozie Kenneth Ugwoke, Simon Horvat, Nejc Umek, Tatjana Stopar Pintarič
    Pharmaceutics.2022; 14(9): 1824.     CrossRef
  • Free, Conjugated, and Bound Phenolics in Peel and Pulp from Four Wampee Varieties: Relationship between Phenolic Composition and Bio-Activities by Multivariate Analysis
    Xue Lin, Yousheng Shi, Pan Wen, Xiaoping Hu, Lu Wang
    Antioxidants.2022; 11(9): 1831.     CrossRef
  • Protocol: Developing a framework to improve glycaemic control among patients with type 2 diabetes mellitus in Kinshasa, Democratic Republic of the Congo
    Jean-Pierre Fina Lubaki, Olufemi Babatunde Omole, Joel Msafiri Francis, David Desseauve
    PLOS ONE.2022; 17(9): e0268177.     CrossRef
  • Triglyceride-glucose index is associated with poor sleep quality in apparently healthy subjects: A cross-sectional study
    Daniela Carolina Avelino, Alessandra da Silva, Larissa Oliveira Chaves, Júlia Cristina Cardoso Carraro, Fernanda de Carvalho Vidigal, Josefina Bressan
    Archives of Endocrinology and Metabolism.2022;[Epub]     CrossRef
  • Molecular mechanisms interlinking biological clock and diabetes mellitus: Effective tools for better management
    Chandrasekaran Sankaranarayanan, Perumal Subramanian
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2022; 16(11): 102639.     CrossRef
  • Amyloid Fibrillation of Insulin: Amelioration Strategies and Implications for Translation
    Megren H. A. Fagihi, Sourav Bhattacharjee
    ACS Pharmacology & Translational Science.2022; 5(11): 1050.     CrossRef
  • Potential Roles of Anti-Inflammatory Plant-Derived Bioactive Compounds Targeting Inflammation in Microvascular Complications of Diabetes
    Yahia A. Kaabi
    Molecules.2022; 27(21): 7352.     CrossRef
  • Additive interaction of diabetes mellitus and chronic kidney disease in cancer patient mortality risk
    Seohyun Kim, Gyuri Kim, Jae Hyeon Kim
    Scientific Reports.2022;[Epub]     CrossRef
  • Re-understanding and focusing on normoalbuminuric diabetic kidney disease
    Na An, Bi-tao Wu, Yu-wei Yang, Zheng-hong Huang, Jia-fu Feng
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Coexistent Lichen Amyloidosis and Acquired Reactive Perforating Collagenosis in Type 2 Diabetes Mellitus and Post-Thyroidectomy Hypothyroidism Due to Papillary Thyroid Carcinoma: A Rare Case
    Eva Krishna Sutedja, Muhamad Radyn Haryadi Widjaya, Hartati Purbo Dharmadji, Pati Aji Achdiat, Laila Tsaqilah
    International Medical Case Reports Journal.2022; Volume 15: 745.     CrossRef
  • Interaction between the stage of chronic kidney disease and diabetes mellitus as factors associated with mortality in chronic kidney disease patients: An external cohort study
    Laura E. Villegas Sierra, Melisa Buriticá Agudelo, Carlos Enrique Yepes Delgado, Yanett Marcela Montoya Jaramillo, Fabián Jaimes Barragan
    Nefrología (English Edition).2022; 42(5): 540.     CrossRef
  • Effects of Pea Protein on Satiety, Postprandial Glucose Response and Appetite Hormones: A Literature Review
    Amy Choi
    Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal.2022; 6(10): 1.     CrossRef
  • Hemoglobin glycation index is associated with incident chronic kidney disease in subjects with impaired glucose metabolism: A 10-year longitudinal cohort study
    Wonjin Kim, Taehwa Go, Dae Ryong Kang, Eun Jig Lee, Ji Hye Huh
    Journal of Diabetes and its Complications.2021; 35(1): 107760.     CrossRef
  • Coronavirus Disease 2019 (SARS-CoV-2) and polycystic ovarian disease: Is there a higher risk for these women?
    Giuseppe Morgante, Libera Troìa, Vincenzo De Leo
    The Journal of Steroid Biochemistry and Molecular Biology.2021; 205: 105770.     CrossRef
  • Regional differences in diabetes across Europe – regression and causal forest analyses
    Péter Elek, Anikó Bíró
    Economics & Human Biology.2021; 40: 100948.     CrossRef
  • Active ingredients and mechanisms of Phellinus linteus (grown on Rosa multiflora) for alleviation of Type 2 diabetes mellitus through network pharmacology
    Ki Kwang Oh, Md. Adnan, Dong Ha Cho
    Gene.2021; 768: 145320.     CrossRef
  • Application of Telemedicine in Diabetes Care: The Time is Now
    Felix Aberer, Daniel A. Hochfellner, Julia K. Mader
    Diabetes Therapy.2021; 12(3): 629.     CrossRef
  • Long-term outcomes after kidney transplant failure and variables related to risk of death and probability of retransplant: Results from a single-center cohort study in Brazil
    Lúcio R. Requião-Moura, Cássio R. Moreira Albino, Paula Rebello Bicalho, Érika de Arruda Ferraz, Luciana Mello de Mello Barros Pires, Maurício Fregonesi Rodrigues da Silva, Alvaro Pacheco-Silva, Justyna Gołębiewska
    PLOS ONE.2021; 16(1): e0245628.     CrossRef
  • Estimating the disease burden of Korean type 2 diabetes mellitus patients considering its complications
    Juyoung Kim, Seok-Jun Yoon, Min-Woo Jo, Brecht Devleesschauwer
    PLOS ONE.2021; 16(2): e0246635.     CrossRef
  • Susceptibility for Some Infectious Diseases in Patients With Diabetes: The Key Role of Glycemia
    Jesús Chávez-Reyes, Carlos E. Escárcega-González, Erika Chavira-Suárez, Angel León-Buitimea, Priscila Vázquez-León, José R. Morones-Ramírez, Carlos M. Villalón, Andrés Quintanar-Stephano, Bruno A. Marichal-Cancino
    Frontiers in Public Health.2021;[Epub]     CrossRef
  • Prediabetes, Diabetes, and the Risk of All-Cause and Cause-Specific Mortality in a Japanese Working Population: Japan Epidemiology Collaboration on Occupational Health Study
    Zobida Islam, Shamima Akter, Yosuke Inoue, Huan Hu, Keisuke Kuwahara, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Hiroko Okazaki, Toshiaki Miyamoto, Takayuki Ogasawara, Naoko Sasaki, Akihiko Uehara, Makoto Yamamoto, Takeshi Kochi, Masafumi Eguchi, Tai
    Diabetes Care.2021; 44(3): 757.     CrossRef
  • Proportion and mortality of Iranian diabetes mellitus, chronic kidney disease, hypertension and cardiovascular disease patients with COVID-19: a meta-analysis
    Hamid Mirjalili, Seyed Alireza Dastgheib, Seyed Hossein Shaker, Reza Bahrami, Mahta Mazaheri, Seyed Mohamad Hossein Sadr-Bafghi, Jalal Sadeghizadeh-Yazdi, Hossein Neamatzadeh
    Journal of Diabetes & Metabolic Disorders.2021; 20(1): 905.     CrossRef
  • Prevalence and associated factors of diabetes mellitus among tuberculosis patients in Brunei Darussalam: A 6-year retrospective cohort study
    Nurfakhrina Omar, Justin Wong, Kyaw Thu, Md Fathi Alikhan, Liling Chaw
    International Journal of Infectious Diseases.2021; 105: 267.     CrossRef
  • Diabetes and COVID-19
    Zohair Jamil Gazzaz
    Open Life Sciences.2021; 16(1): 297.     CrossRef
  • Review of potential risk groups for coronavirus disease 2019 (COVID-19)
    M. Naveed, M. Naeem, M. ur Rahman, M. Gul Hilal, M.A. Kakakhel, G. Ali, A. Hassan
    New Microbes and New Infections.2021; 41: 100849.     CrossRef
  • COVID-19 from the interdisciplinary standpoint. Round table
    M. N. Mamedov, Yu. V. Rodionova, I. S. Yavelov, M. I. Smirnova, E. N. Dudinskaya, V. I. Potievskaya
    Cardiovascular Therapy and Prevention.2021; 20(3): 2849.     CrossRef
  • Diabetes is a major cause of influenza-associated mortality in Mexico
    A. Gómez-Gómez, E.L. Sánchez-Ramos, D.E. Noyola
    Revue d'Épidémiologie et de Santé Publique.2021; 69(4): 205.     CrossRef
  • Ameliorative potential of Operculina turpethum against streptozotocin-induced diabetes in rats: biochemical and histopathological studies
    Neeraj Choudhary, Gopal L. Khatik, Rekha Sharma, Navneet Khurana, Richard Lobo, Shvetank Bhatt, Devesh Tewari, Ashish Suttee
    3 Biotech.2021;[Epub]     CrossRef
  • Current utilization patterns for long-acting insulin analogues including biosimilars among selected Asian countries and the implications for the future
    Brian Godman, Mainul Haque, Santosh Kumar, Salequl Islam, Jaykaran Charan, Farhana Akter, Amanj Kurdi, Eleonora Allocati, Muhammed Abu Bakar, Sagir Abdur Rahim, Nusrat Sultana, Farzana Deeba, M. A. Halim Khan, A. B. M Muksudul Alam, Iffat Jahan, Zubair Ma
    Current Medical Research and Opinion.2021; 37(9): 1529.     CrossRef
  • Association between cardiometabolic risk factors and COVID-19 susceptibility, severity and mortality: a review
    Yasaman Sharifi, Moloud Payab, Erfan Mohammadi-Vajari, Seyed Morsal Mosallami Aghili, Farshad Sharifi, Neda Mehrdad, Elham Kashani, Zhaleh Shadman, Bagher Larijani, Mahbube Ebrahimpur
    Journal of Diabetes & Metabolic Disorders.2021; 20(2): 1743.     CrossRef
  • Association of ACE I/D and PAI-1 4G/5G polymorphisms with susceptibility to type 2 diabetes mellitus
    Somaye Miri, Mohammad Hasan Sheikhha, Seyed Alireza Dastgheib, Seyed Amir Shaker, Hossein Neamatzadeh
    Journal of Diabetes & Metabolic Disorders.2021; 20(2): 1191.     CrossRef
  • Assessment and Management of Diabetic Patients During the COVID-19 Pandemic
    Amit K Verma, Mirza Masroor Ali Beg, Deepti Bhatt, Kapil Dev, Mohammed A Alsahli, Arshad Husain Rahmani, Yamini Goyal
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 3131.     CrossRef
  • Higher admission activated partial thromboplastin time, neutrophil-lymphocyte ratio, serum sodium, and anticoagulant use predict in-hospital COVID-19 mortality in people with Diabetes: Findings from Two University Hospitals in the U.K
    Ahmed Iqbal, Marni Greig, Muhammad Fahad Arshad, Thomas H. Julian, Sher Ee Tan, Jackie Elliott
    Diabetes Research and Clinical Practice.2021; 178: 108955.     CrossRef
  • Risk factors for severe outcomes in people with diabetes hospitalised for COVID-19: a cross-sectional database study
    Emilio Ortega, Rosa Corcoy, Mònica Gratacòs, Francesc Xavier Cos Claramunt, Manel Mata-Cases, Ramon Puig-Treserra, Jordi Real, Bogdan Vlacho, Esmeralda Castelblanco, Pere Domingo, Kamlesh Khunti, Josep Franch-Nadal, Didac Mauricio
    BMJ Open.2021; 11(7): e051237.     CrossRef
  • Diabetes increases the risk of COVID-19 in an altitude dependent manner: An analysis of 1,280,806 Mexican patients
    Juan Alonso Leon-Abarca, Arianna Portmann-Baracco, Mayte Bryce-Alberti, Carlos Ruiz-Sánchez, Roberto Alfonso Accinelli, Jorge Soliz, Gustavo Francisco Gonzales, Chiara Lazzeri
    PLOS ONE.2021; 16(8): e0255144.     CrossRef
  • Botanical Interventions to Improve Glucose Control and Options for Diabetes Therapy
    Peter Smoak, Susan J. Burke, J. Jason Collier
    SN Comprehensive Clinical Medicine.2021; 3(12): 2465.     CrossRef
  • Antidiabetic bioactive compounds from Tetrastigma angustifolia (Roxb.) Deb and Oxalis debilis Kunth.: Validation of ethnomedicinal claim by in vitro and in silico studies
    Julfikar Ali Junejo, Kamaruz Zaman, Mithun Rudrapal, Ismail Celik, Emmanuel Ifeanyi Attah
    South African Journal of Botany.2021; 143: 164.     CrossRef
  • SGLT2 Inhibition for Cardiovascular Diseases, Chronic Kidney Disease, and NAFLD
    Moein Ala
    Endocrinology.2021;[Epub]     CrossRef
  • Hospitalization costs with degludec versus glargine U100 for patients with type 2 diabetes at high cardiovascular risk: Canadian costs applied to SAEs from a randomized outcomes trial
    Jean-Eric Tarride, Mansoor Husain, Andreas Andersen, Jens Gundgaard, Maria Luckevich, Thomas Mark, Lily Wagner, Thomas R. Pieber
    Journal of Medical Economics.2021; 24(1): 1318.     CrossRef
  • Traditional Uses, Pharmacological Effects, and Molecular Mechanisms of Licorice in Potential Therapy of COVID-19
    Qian-hui Zhang, Hao-zhou Huang, Min Qiu, Zhen-feng Wu, Zhan-chang Xin, Xin-fu Cai, Qiang Shang, Jun-zhi Lin, Ding-kun Zhang, Li Han
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Recent Updates on Free Fatty Acid Receptor 1 (GPR-40) Agonists for the Treatment of Type 2 Diabetes Mellitus
    Lata Rani, Ajmer Singh Grewal, Neelam Sharma, Sukhbir Singh
    Mini-Reviews in Medicinal Chemistry.2021; 21(4): 426.     CrossRef
  • Low Levels of Influenza Vaccine Uptake among the Diabetic Population in Spain: A Time Trend Study from 2011 to 2020
    Jose J. Zamorano-Leon, Rodrigo Jimenez-Garcia, Ana Lopez-de-Andres, Javier de-Miguel-Diez, David Carabantes-Alarcon, Romana Albaladejo-Vicente, Rosa Villanueva-Orbaiz, Khaoula Zekri-Nechar, Sara Sanz-Rojo
    Journal of Clinical Medicine.2021; 11(1): 68.     CrossRef
  • Effects of Short-term Mobile Application Use on Weight Reduction for Patients with Type 2 Diabetes
    Seung Eun Lee, Su-Kyung Park, Ye-Seul Park, Kyoung-Ah Kim, Han Seok Choi, Sang Woo Oh
    Journal of Obesity & Metabolic Syndrome.2021; 30(4): 345.     CrossRef
  • Diabetes mellitus in combination with COVID-19: modern views on therapy
    V.I. Tsymbaliuk, M.D. Tronko, Y.G. Antypkin, S.V. Kushnirenko, V.V. Popova
    REPRODUCTIVE ENDOCRINOLOGY.2021; (57): 8.     CrossRef
  • Dietary aldose reductase inhibitors and prevention of diabetic complications
    Ameena Anjum, Janamolla Sreeja, Yarlagadda Swapna, Rajesh Bolleddu, Sama Venkatesh
    Indian Journal of Health Sciences and Biomedical Research (KLEU).2021; 14(2): 194.     CrossRef
  • Cohort Profile: The Maule Cohort (MAUCO)
    Catterina Ferreccio, Andrea Huidobro, Sandra Cortés, Claudia Bambs, Pablo Toro, Vanessa Van De Wyngard, Johanna Acevedo, Fabio Paredes, Pía Venegas, Hugo Verdejo, Ximena Oyarzún-González, Paz Cook, Pablo F Castro, Claudia Foerster, Claudio Vargas, Jill Ko
    International Journal of Epidemiology.2020; 49(3): 760.     CrossRef
  • Treating Dyslipidemias in the Primary Prevention of Atherosclerotic Cardiovascular Disease in Older Adults with Diabetes Mellitus
    MengHee Tan, Mark Paul MacEachern
    Clinics in Geriatric Medicine.2020; 36(3): 457.     CrossRef
  • Increased Mortality Risk in People with Type 2 Diabetes Mellitus in Lithuania
    Donata Linkeviciute-Ulinskiene, Auguste Kaceniene, Audrius Dulskas, Ausvydas Patasius, Lina Zabuliene, Giedre Smailyte
    International Journal of Environmental Research and Public Health.2020; 17(18): 6870.     CrossRef
  • Proteinuria Is Associated with Carotid Artery Atherosclerosis in Non-Albuminuric Type 2 Diabetes: A Cross-Sectional Study
    Jaehyun Bae, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
    Journal of Clinical Medicine.2020; 9(1): 136.     CrossRef
  • COVID-19 and diabetes: Knowledge in progress
    Akhtar Hussain, Bishwajit Bhowmik, Nayla Cristina do Vale Moreira
    Diabetes Research and Clinical Practice.2020; 162: 108142.     CrossRef
  • Peripheral arterial endothelial dysfunction predicts future cardiovascular events in diabetic patients with albuminuria: a prospective cohort study
    Bo Kyung Koo, Woo-Young Chung, Min Kyong Moon
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Risk Factors in and Long-Term Survival of Patients with Post-Transplantation Diabetes Mellitus: A Retrospective Cohort Study
    Ching-Yao Cheng, Cheng-Hsu Chen, Ming-Fen Wu, Ming-Ju Wu, Jun-Peng Chen, Ying-Mei Liu, Yu-Chi Hou, Hue-Yu Wang
    International Journal of Environmental Research and Public Health.2020; 17(12): 4581.     CrossRef
  • Fasting Plasma Glucose Variability and Gastric Cancer Risk in Individuals Without Diabetes Mellitus: A Nationwide Population-Based Cohort Study
    So-hyeon Hong, Eunjin Noh, Jinsil Kim, Soon Young Hwang, Jun A. Kim, You-Bin Lee, Eun Roh, Kyung Mook Choi, Sei Hyun Baik, Geum Joon Cho, Hye Jin Yoo
    Clinical and Translational Gastroenterology.2020; 11(9): e00221.     CrossRef
  • Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1
    Yong Yang, Yong Wang, Zuowen He, Yunchang Liu, Chen Chen, Yan Wang, Dao Wen Wang, Hong Wang
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • Beta Cell Imaging—From Pre-Clinical Validation to First in Man Testing
    Stephane Demine, Michael L. Schulte, Paul R. Territo, Decio L. Eizirik
    International Journal of Molecular Sciences.2020; 21(19): 7274.     CrossRef
  • The role of dental insurance in mitigating mortality among working‐age U.S. adults with periodontitis
    Naveed Sadiq, Janice C. Probst, Anwar T. Merchant, Amy B. Martin, Deepika Shrestha, M. Mahmud Khan
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  • Antidiabetic Activity of Triterpenoids from Anisophyllea disticha
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    Journal of Physics: Conference Series.2020; 1655(1): 012033.     CrossRef
  • Therapeutic efficacy of umbilical cord-derived stem cells for diabetes mellitus: a meta-analysis study
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  • Loss of Smell in COVID-19 Patients: Lessons and Opportunities
    Dennis Mathew
    Frontiers in Human Neuroscience.2020;[Epub]     CrossRef
  • Diabetes mellitus and COVID-19: current issues of pathogenesis, clinic and therapy. Literature review
    В. І. Цимбалюк, М. Д. Тронько, Ю. Г. Антипкін, В. В. Попова
    REPRODUCTIVE ENDOCRINOLOGY.2020; (54): 8.     CrossRef
  • Increased Age of Death and Change in Causes of Death Among Persons With Diabetes Mellitus From the Korean National Health Insurance and Statistical Information Service, 2006 to 2018
    Eugene Han, Sun Ok Song, Hye Soon Kim, Kang Ju Son, Sun Ha Jee, Bong-Soo Cha, Byung-Wan Lee
    SSRN Electronic Journal .2020;[Epub]     CrossRef
  • Purva Rupeeyam of bhela indriya sthana-an explorative study
    Kshama Gupta, Prasad Mamidi
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  • The COVID-19 pandemic and diabetes mellitus
    Athanasia Papazafiropoulou, Stavros Antonopoulos
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  • Diabetes and Cancer: Cancer Should Be Screened in Routine Diabetes Assessment
    Sunghwan Suh, Kwang-Won Kim
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  • Diabetes Mellitus, Still Major Threat to Mortality from Various Causes
    Nam Hoon Kim
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  • The Need to Improve the Quality of Diabetes Care in Korea
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    Journal of Korean Medical Science.2019;[Epub]     CrossRef
Epidemiology
Oral Glucose Tolerance Testing Allows Better Prediction of Diabetes in Women with a History of Gestational Diabetes Mellitus
Tae Jung Oh, Yeong Gi Kim, Sunyoung Kang, Joon Ho Moon, Soo Heon Kwak, Sung Hee Choi, Soo Lim, Kyong Soo Park, Hak C. Jang, Joon-Seok Hong, Nam H. Cho
Diabetes Metab J. 2019;43(3):342-349.   Published online December 7, 2018
DOI: https://doi.org/10.4093/dmj.2018.0086
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AbstractAbstract PDFPubReader   
Background

We aimed to identify the postpartum metabolic factors that were associated with the development of diabetes in women with a history of gestational diabetes mellitus (GDM). In addition, we examined the role of the oral glucose tolerance test (OGTT) in the prediction of future diabetes.

Methods

We conducted a prospective study of 179 subjects who previously had GDM but did not have diabetes at 2 months postpartum. The initial postpartum examination including a 75-g OGTT and the frequently sampled intravenous glucose tolerance test (FSIVGTT) was performed 12 months after delivery, and annual follow-up visits were made thereafter.

Results

The insulinogenic index (IGI30) obtained from the OGTT was significantly correlated with the acute insulin response to glucose (AIRg) obtained from the FSIVGTT. The disposition indices obtained from the OGTT and FSIVGTT were also significantly correlated. Women who progressed to diabetes had a lower insulin secretory capacity including IGI30, AIRg, and disposition indices obtained from the FSIVGTT and OGTT compared with those who did not. However, the insulin sensitivity indices obtained from the OGTT and FSIVGTT did not differ between the two groups. Multivariate logistic regression analysis showed that the 2-hour glucose and disposition index obtained from the FSIVGTT were significant postpartum metabolic risk factors for the development of diabetes.

Conclusion

We identified a crucial role of β-cell dysfunction in the development of diabetes in Korean women with previous GDM. The 2-hour glucose result from the OGTT is an independent predictor of future diabetes. Therefore, the OGTT is crucial for better prediction of future diabetes in Korean women with previous GDM.

Citations

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  • Diagnosis and management of gestational diabetes mellitus
    Tae Jung Oh
    Journal of the Korean Medical Association.2023; 66(7): 414.     CrossRef
  • Risk factors for women with gestational diabetes mellitus developing type 2 diabetes and the impact on children's health
    Yi‐Ling Chiou, Chich‐Hsiu Hung, Ching‐Yun Yu, Te‐Fu Chan, Ming‐Gwo Liu
    Journal of Clinical Nursing.2022; 31(7-8): 1005.     CrossRef
  • Postprandial Free Fatty Acids at Mid-Pregnancy Increase the Risk of Large-for-Gestational-Age Newborns in Women with Gestational Diabetes Mellitus
    So-Yeon Kim, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyung-Soo Kim
    Diabetes & Metabolism Journal.2022; 46(1): 140.     CrossRef
  • Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications
    Joon Ho Moon, Hak Chul Jang
    Diabetes & Metabolism Journal.2022; 46(1): 3.     CrossRef
  • Higher Muscle Mass Protects Women with Gestational Diabetes Mellitus from Progression to Type 2 Diabetes Mellitus
    Yujin Shin, Joon Ho Moon, Tae Jung Oh, Chang Ho Ahn, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang
    Diabetes & Metabolism Journal.2022; 46(6): 890.     CrossRef
  • Pancreatic fat accumulation is associated with decreased β‐cell function and deterioration in glucose tolerance in Korean adults
    Sang Ouk Chin, You‐Cheol Hwang, In‐Jin Cho, In‐Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung
    Diabetes/Metabolism Research and Reviews.2021;[Epub]     CrossRef
  • The Clinical Characteristics of Gestational Diabetes Mellitus in Korea: A National Health Information Database Study
    Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park
    Endocrinology and Metabolism.2021; 36(3): 628.     CrossRef
  • Bihormonal dysregulation of insulin and glucagon contributes to glucose intolerance development at one year post-delivery in women with gestational diabetes: a prospective cohort study using an early postpartum 75-g glucose tolerance test
    Riyoko Shigeno, Ichiro Horie, Masaki Miwa, Ayako Ito, Ai Haraguchi, Shoko Natsuda, Satoru Akazawa, Ai Nagata, Yuri Hasegawa, Shoko Miura, Kiyonori Miura, Atsushi Kawakami, Norio Abiru
    Endocrine Journal.2021; 68(8): 919.     CrossRef
  • Risk factors during the early postpartum period for type 2 diabetes mellitus in women with gestational diabetes
    Maki Kawasaki, Naoko Arata, Naoko Sakamoto, Anna Osamura, Siori Sato, Yoshihiro Ogawa, Ichiro Yasuhi, Masako Waguri, Yuji Hiramatsu
    Endocrine Journal.2020; 67(4): 427.     CrossRef
  • Cod-Liver Oil Improves Metabolic Indices and hs-CRP Levels in Gestational Diabetes Mellitus Patients: A Double-Blind Randomized Controlled Trial
    Shuli Yang, Ruixin Lin, Lihui Si, Zhuo Li, Wenwen Jian, Qing Yu, Yan Jia
    Journal of Diabetes Research.2019; 2019: 1.     CrossRef
Epidemiology
Association of Visit-to-Visit Variability of Blood Pressure with Cardiovascular Disease among Type 2 Diabetes Mellitus Patients: A Cohort Study
Zhe-Bin Yu, Die Li, Xue-Yu Chen, Pei-Wen Zheng, Hong-Bo Lin, Meng-Ling Tang, Ming-Juan Jin, Jian-Bing Wang, Kun Chen
Diabetes Metab J. 2019;43(3):350-367.   Published online March 6, 2019
DOI: https://doi.org/10.4093/dmj.2018.0108
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AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Increasing evidence has shown that visit-to-visit variability (VVV) of blood pressure (BP) is associated with an increased risk of cardiovascular disease (CVD). The objective of this study was to evaluate the impact of VVV of systolic blood pressure (SBP) and diastolic blood pressure (DBP) on the risk of CVD among patients with type 2 diabetes mellitus (T2DM) in China.

Methods

We conducted a retrospective cohort study of 10,163 T2DM patients who were not previously diagnosed with CVD from January 2008 to December 2012 in Ningbo, China. The VVV of BP was calculated using five metrics, including standard deviation (SD), coefficient of variation (CV), variation independent of mean, average real variability, and successive variability (SV) of measurements, obtained over a 24-month measurement period. Hazard ratios and 95% confidence intervals (CIs) were estimated by Cox proportional hazards regression models for the associations of variability in BP with risk of CVD.

Results

A total of 894 CVD events were observed during a median follow-up of 49.5 months. The hazard ratio in the highest quintile of SD of SBP was 1.24 (95% CI, 1.01 to 1.52) compared with patients in the lowest quintile. The association between higher VVV of DBP and risk of CVD was not consistent across different metrics and sensitivity analyses.

Conclusion

Higher VVV of SBP was associated with an increased risk of CVD, irrespective of the mean SBP level. Future studies are needed to confirm these findings.

Citations

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  • Association between Variability of Metabolic Risk Factors and Cardiometabolic Outcomes
    Min Jeong Park, Kyung Mook Choi
    Diabetes & Metabolism Journal.2022; 46(1): 49.     CrossRef
  • Joint effect of blood pressure and glycemic variation on the risk of cardiovascular morbidity and mortality in persons with type 2 diabetes
    Cheng-Chieh Lin, Chia-Ing Li, Ya-Ling Juan, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li
    Metabolism.2022; 136: 155308.     CrossRef
  • Visit‐to‐visit variability of blood pressure and risk of macrovascular and microvascular complications in patients with type 2 diabetes: A Chinese primary‐care cohort study
    Ying Deng, Yin Liu, Shengchao Zhang, Hanbing Yu, Xiaozhou Zeng, Rongrong An, Zhenyuan Chen, Na Sun, Xiaoxv Yin, Yue Dong
    Journal of Diabetes.2022; 14(11): 767.     CrossRef
  • Visit‑to‑visit blood pressure variability is associated with arterial stiffness in Chinese adults: A prospective analysis
    Yuwen Zhang, Lizhan Bie, Mian Li, Tiange Wang, Min Xu, Jieli Lu, Shuangyuan Wang, Jie Zhang, Yufang Bi, Weiqing Wang, Guang Ning, Yuhong Chen, Yu Xu
    The Journal of Clinical Hypertension.2021; 23(4): 802.     CrossRef
  • Variability of risk factors and diabetes complications
    Antonio Ceriello, Francesco Prattichizzo
    Cardiovascular Diabetology.2021;[Epub]     CrossRef
  • Effectiveness of statin intensive therapy in type 2 diabetes mellitus with high visit-to-visit blood pressure variability
    Shota Ikeda, Keisuke Shinohara, Nobuyuki Enzan, Shouji Matsushima, Takeshi Tohyama, Kouta Funakoshi, Junji Kishimoto, Hiroshi Itoh, Issei Komuro, Hiroyuki Tsutsui
    Journal of Hypertension.2021; 39(7): 1435.     CrossRef
  • Prognostic importance of visit-to-visit blood pressure variability for micro- and macrovascular outcomes in patients with type 2 diabetes: The Rio de Janeiro Type 2 Diabetes Cohort Study
    Claudia R. L. Cardoso, Nathalie C. Leite, Gil F. Salles
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Impact of visit-to-visit variability in blood pressure on coronary plaque as assessed by integrated backscatter intravascular ultrasound
    Yuta Kato, Atsushi Iwata, Makito Futami, Motoki Yamashita, Eiji Shigemoto, Takashi Kuwano, Makoto Sugihara, Shin-Ichiro Miura
    Clinical and Experimental Hypertension.2020; 42(7): 608.     CrossRef
  • VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY IN RURAL MALES WITH ARTERIAL HYPERTENSION: ASSOCIATION WITH NON-VALVULAR ATRIAL FIBRILLATION
    T.I. Nimtsovych, A.M. Kravchenko, O.Yu. Mishcheniuk, К.О. Mikhaliev, T.Ya. Chursina
    Клінічна та профілактична медицина.2020; (2): 90.     CrossRef
  • VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY AND TARGET ORGAN DAMAGE IN RURAL DWELLERS WITH UNCOMPLICATED ARTERIAL HYPERTENSION
    Tetiana I. Nimtsovych, Anatolii M. Kravchenko, Olha Yu. Mishcheniuk, Tamara Ya. Chursina, Кyrylo О. Mikhaliev, Viktor P. Polovyi
    Wiadomości Lekarskie.2020; 73(12): 2591.     CrossRef
  • HDL-Cholesterol, Its Variability, and the Risk of Diabetes: A Nationwide Population-Based Study
    Seung-Hwan Lee, Hun-Sung Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Kyungdo Han, Mee Kyoung Kim
    The Journal of Clinical Endocrinology & Metabolism.2019; 104(11): 5633.     CrossRef
Others
Serum R-Spondin 1 Is a New Surrogate Marker for Obesity and Insulin Resistance
Yea Eun Kang, Ji Min Kim, Hyon-Seung Yi, Kyong Hye Joung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
Diabetes Metab J. 2019;43(3):368-376.   Published online October 23, 2018
DOI: https://doi.org/10.4093/dmj.2018.0066
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AbstractAbstract PDFPubReader   
Background

Recent in vivo studies indicated that R-spondin 1 (RSPO1) regulates food intake and increases insulin secretion, but its role in humans remains unknown. This study investigated the association between serum levels of RSPO1 and diverse metabolic parameters in humans.

Methods

The study population consisted of 43 subjects with newly diagnosed diabetes mellitus, and 79 non-diabetic participants. Serum levels of RSPO1 were measured using the enzyme-linked immunosorbent assay. The relationships between circulating RSPO1 and diverse metabolic parameters were analyzed.

Results

Circulating RSPO1 levels increased to a greater extent in the obese group than in the lean group. Moreover, serum levels of RSPO1 were higher in the insulin-resistant group than in the insulin-sensitive group. Serum levels of RSPO1 were significantly correlated with a range of metabolic parameters including body mass index, fasting C-peptide, homeostasis model assessment of insulin resistance index, and lipid profile. Moreover, levels were significantly associated with insulin resistance and obesity in non-diabetic subjects.

Conclusion

This study demonstrated the association between serum levels of RSPO1 and a range of metabolic parameters in humans. Serum levels of RSPO1 are significantly related to obesity and insulin resistance, although the precise mechanisms remain unknown.

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    Jordan N Reed, Jiansheng Huang, Yong Li, Lijiang Ma, Dhanush Banka, Martin Wabitsch, Tianfang Wang, Wen Ding, Johan LM Björkegren, Mete Civelek
    Life Science Alliance.2024; 7(7): e202402603.     CrossRef
  • LGR4: A New Receptor Member in Endocrine and Metabolic Diseases
    Ningning Zhang, Mingyang Yuan, Jiqiu Wang
    Endocrine Reviews.2023; 44(4): 647.     CrossRef
  • R-Spondin1 and tumor necrosis factor-alpha in infertile women with polycystic ovary syndrome: relationships with insulin resistance and other parameters
    Tuğba GÜRBÜZ, Oya GÖKMEN, Asena AYAR MADENLİ, Berna DİLBAZ
    Journal of Health Sciences and Medicine.2023; 6(2): 449.     CrossRef
  • An early prediction model for type 2 diabetes mellitus based on genetic variants and nongenetic risk factors in a Han Chinese cohort
    Jinjin Li, Qun Ye, Hongxiao Jiao, Wanyao Wang, Kai Zhang, Chen Chen, Yuan Zhang, Shuzhi Feng, Ximo Wang, Yubao Chen, Huailin Gao, Fengjiang Wei, Wei-Dong Li
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Emerging Therapeutic Strategies for Attenuating Tubular EMT and Kidney Fibrosis by Targeting Wnt/β-Catenin Signaling
    Lichao Hu, Mengyuan Ding, Weichun He
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Does Serum R-Spondin-1 Play a Role in PCOS Pathophysiology?
    Osman BAŞPINAR, Yasin ŞİMŞEK, Derya KOÇER, Oğuzhan Sıtkı DİZDAR, Hatice KAYIŞ TOPALOĞLU
    Genel Tıp Dergisi.2022; 32(5): 490.     CrossRef
  • Silencing of RSPO1 mitigates obesity-related renal fibrosis in mice by deactivating Wnt/β-catenin pathway
    Xuesong Su, Guangyu Zhou, Mi Tian, Si Wu, Yanqiu Wang
    Experimental Cell Research.2021; 405(2): 112713.     CrossRef
  • Exosome miR‐27a‐3p secreted from adipocytes targets ICOS to promote antitumor immunity in lung adenocarcinoma
    Xuehan Fan, Jingya Wang, Tingting Qin, Yujia Zhang, Wenting Liu, Kaiting Jiang, Dingzhi Huang
    Thoracic Cancer.2020; 11(6): 1453.     CrossRef
  • Integrative Analyses of Genes Associated with Subcutaneous Insulin Resistance
    Manoj Kumar Pujar, Basavaraj Vastrad, Chanabasayya Vastrad
    Biomolecules.2019; 9(2): 37.     CrossRef
Letter
Response
Corrigendum
Corrigenda: Omission of the Description of Informed Consent
Diabetes Metab J. 2019;43(3):381-381.   Published online June 13, 2019
DOI: https://doi.org/10.4093/dmj.2018.0100
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