Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Previous issues

Page Path
HOME > Browse > Previous issues
13 Previous issues
Filter
Filter
Article category
Keywords
Authors
Funded articles
Volume 43(1); February 2019
Prev issue Next issue
Special Editorial
DMJ, Better than Yesterday, More Brilliant Tomorrow
Kyu Chang Won
Diabetes Metab J. 2019;43(1):1-2.   Published online December 17, 2018
DOI: https://doi.org/10.4093/dmj.2019.0030
  • 2,596 View
  • 53 Download
  • 1 Web of Science
  • 2 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • Effects of selenium on coronary artery disease, type 2 diabetes and their risk factors: a Mendelian randomization study
    Abigail A. Rath, H. Simon Lam, C. Mary Schooling
    European Journal of Clinical Nutrition.2021; 75(11): 1668.     CrossRef
  • Diabetes and Metabolism Journal in 2020: Good to Great
    In-Kyung Jeong
    Diabetes & Metabolism Journal.2020; 44(1): 1.     CrossRef
Reviews
Complications
Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What Is Unmet
Vincenza Spallone
Diabetes Metab J. 2019;43(1):3-30.   Published online November 2, 2018
DOI: https://doi.org/10.4093/dmj.2018.0259
  • 15,736 View
  • 396 Download
  • 151 Web of Science
  • 156 Crossref
AbstractAbstract PDFPubReader   

The burden of diabetic cardiovascular autonomic neuropathy (CAN) is expected to increase due to the diabetes epidemic and its early and widespread appearance. CAN has a definite prognostic role for mortality and cardiovascular morbidity. Putative mechanisms for this are tachycardia, QT interval prolongation, orthostatic hypotension, reverse dipping, and impaired heart rate variability, while emerging mechanisms like inflammation support the pervasiveness of autonomic dysfunction. Efforts to overcome CAN under-diagnosis are on the table: by promoting screening for symptoms and signs; by simplifying cardiovascular reflex tests; and by selecting the candidates for screening. CAN assessment allows for treatment of its manifestations, cardiovascular risk stratification, and tailoring therapeutic targets. Risk factors for CAN are mainly glycaemic control in type 1 diabetes mellitus (T1DM) and, in addition, hypertension, dyslipidaemia, and obesity in type 2 diabetes mellitus (T2DM), while preliminary data regard glycaemic variability, vitamin B12 and D changes, oxidative stress, inflammation, and genetic biomarkers. Glycaemic control prevents CAN in T1DM, whereas multifactorial intervention might be effective in T2DM. Lifestyle intervention improves autonomic function mostly in pre-diabetes. While there is no conclusive evidence for a disease-modifying therapy, treatment of CAN manifestations is available. The modulation of autonomic function by SGLT2i represents a promising research field with possible clinical relevance.

Citations

Citations to this article as recorded by  
  • Rectal sensitivity correlated with gastrointestinal‐mediated glucose disposal, but not the incretin effect
    Sondre Meling, Erling Tjora, Heike Eichele, Rasmus B. Nedergaard, Filip K. Knop, Niels Ejskjaer, Siri Carlsen, Pål R. Njølstad, Christina Brock, Eirik Søfteland
    Endocrinology, Diabetes & Metabolism.2024;[Epub]     CrossRef
  • Glucose metabolism and autonomic function in healthy individuals and patients with type 2 diabetes mellitus at rest and during exercise
    Takuto Hamaoka, Urs A. Leuenberger, Rachel C. Drew, Matthew Murray, Cheryl Blaha, Jonathan Carter Luck, Lawrence I. Sinoway, Jian Cui
    Experimental Physiology.2024; 109(2): 214.     CrossRef
  • Quantification of lipoproteins by proton nuclear magnetic resonance spectroscopy (1H-NMRS) improves the prediction of cardiac autonomic dysfunction in patients with type 1 diabetes
    L. Nattero-Chávez, M. Insenser, N. Amigó, S. Samino, N. Martínez-Micaelo, B. Dorado Avendaño, A. Quintero Tobar, H. F. Escobar-Morreale, M. Luque-Ramírez
    Journal of Endocrinological Investigation.2024;[Epub]     CrossRef
  • Predictors of pacemaker requirement in patients with implantable loop recorder and unexplained syncope: A systematic review and meta‐analysis
    Moein Zangiabadian, Kiarash Soltani, Yasaman Gholinejad, Reyhane Yahya, Shayan Bastami, Mohammad Ali Akbarzadeh, Mohammad Sharifian Ardestani, Azadeh Aletaha
    Clinical Cardiology.2024;[Epub]     CrossRef
  • No clear evidence of neuropathy among patients with high risk for the development of prediabetes/diabetes—a pilot study
    Anna E. Körei, Magdolna Békeffy, Adrienn Menyhárt, Karola Osgyán, Ildikó Istenes, Viktor J. Horváth, Péter Kempler
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications
    Danyale Berry, Justice Ene, Aakash Nathani, Mandip Singh, Yan Li, Changchun Zeng
    Biomedicines.2024; 12(3): 489.     CrossRef
  • Oxidative stress, endothelial dysfunction, and N-acetylcysteine in type-2 diabetes mellitus
    Xin Li, Junyong Zou, Aiping Lin, Jingshu Chi, Hong Hao, Hong Chen, Zhenguo Liu
    Antioxidants & Redox Signaling.2024;[Epub]     CrossRef
  • High dose cholecalciferol supplementation causing morning blood pressure reduction in patients with type 1 diabetes mellitus and cardiovascular autonomic neuropathy
    João Felício, Lorena Moraes, Gabriela Lemos, Ícaro Souza, Giovana Vieira, Lilian Silva, Natércia Queiroz, Ana Carolina Souza, Franciane Melo, João Felício Abrahão Neto, Hana Britto, Manuela Lemos, Márcia Santos, Priscila Figueiredo, Ana Regina Motta, Meli
    Scientific Reports.2024;[Epub]     CrossRef
  • Transcutaneous vagal nerve stimulation for treating gastrointestinal symptoms in individuals with diabetes: a randomised, double-blind, sham-controlled, multicentre trial
    Ditte S. Kornum, Davide Bertoli, Huda Kufaishi, Anne-Marie Wegeberg, Tina Okdahl, Esben B. Mark, Katrine L. Høyer, Jens B. Frøkjær, Birgitte Brock, Klaus Krogh, Christian S. Hansen, Filip K. Knop, Christina Brock, Asbjørn M. Drewes
    Diabetologia.2024;[Epub]     CrossRef
  • Independent and interactive associations of heart rate and obesity with type 2 diabetes mellites: A population‐based study
    Tianxin Zhu, Qingyu Chen, Hongxing Chen, Lili You, Dan Liu, Xiaoyun Zhang, Feng Li, Hongshi Wu, Juying Tang, Diaozhu Lin, Kan Sun, Li Yan, Meng Ren
    Journal of Diabetes.2024;[Epub]     CrossRef
  • Mortality risk factors in newly diagnosed diabetic cardiac autonomic neuropathy
    Bruce A. Chase, Sylwia Pocica, Roberta Frigerio, Katerina Markopoulou, Demetrius M. Maraganore, Navamon Aunaetitrakul, Alexander Epshteyn, Alexandru C. Barboi
    Clinical Autonomic Research.2023; 33(6): 903.     CrossRef
  • Autonomic symptoms and associated factors in patients with chronic heart failure
    Hellen Da Silva, Sofie Pardaens, Marc Vanderheyden, Johan De Sutter, Heleen Demeyer, Michel De Pauw, Laurent Demulier, Jan Stautemas, Patrick Calders
    Acta Cardiologica.2023; 78(2): 203.     CrossRef
  • Incretins and microvascular complications of diabetes: neuropathy, nephropathy, retinopathy and microangiopathy
    Jonathan Goldney, Jack A. Sargeant, Melanie J. Davies
    Diabetologia.2023; 66(10): 1832.     CrossRef
  • Functional and morphometric assessment of small-fibre damage in late-onset hereditary transthyretin amyloidosis with polyneuropathy: the controversial relation between small-fibre-related symptoms and diagnostic test findings
    Eleonora Galosi, Luca Leonardi, Pietro Falco, Giuseppe Di Pietro, Alessandra Fasolino, Nicoletta Esposito, Caterina Leone, Giulia Di Stefano, Maurizio Inghilleri, Marco Luigetti, Antonini Giovanni, Andrea Truini
    Amyloid.2023; 30(1): 59.     CrossRef
  • In vivo molecular imaging of cardiac angiogenesis in persons with and without type 2 diabetes: A cross‐sectional 68 Ga‐RGD‐PET study
    Jens Christian Laursen, Ida Kirstine Bull Rasmussen, Emilie Hein Zobel, Philip Hasbak, Lene Holmvang, Christian Stevns Hansen, Bernt Johan von Scholten, Marie Frimodt‐Møller, Peter Rossing, Tine Willum Hansen, Andreas Kjaer, Rasmus Sejersten Ripa
    Diabetic Medicine.2023;[Epub]     CrossRef
  • Cardiac innervations in diabetes mellitus—Anatomical evidence of neuropathy
    Natalija Filipović, Maja Marinović Guić, Vana Košta, Katarina Vukojević
    The Anatomical Record.2023; 306(9): 2345.     CrossRef
  • Clinical Predictors of Pacing Device Implantation in Implantable Cardiac Monitor Recipients for Unexplained Syncope
    Reina Tonegawa-Kuji, Yuko Y. Inoue, Michikazu Nakai, Koshiro Kanaoka, Yoko Sumita, Yuichiro Miyazaki, Akinori Wakamiya, Keiko Shimamoto, Nobuhiko Ueda, Kenzaburo Nakajima, Naoya Kataoka, Mitsuru Wada, Kenichiro Yamagata, Kohei Ishibashi, Koji Miyamoto, Sa
    CJC Open.2023; 5(4): 259.     CrossRef
  • Cardiovascular autonomic reflex tests using a handheld device in the diagnosis of cardiovascular autonomic neuropathy in patients with schizophrenia
    Laura Blok-Husum, Milka Ane Rank Brcelic, Hanin Kawa Farman Kawal Bassi, Svend Eggert Jensen, Rene Ernst Nielsen, Kristian Kragholm, Jesper Fleischer, Esben Laugesen, Christoffer Polcwiartek
    American Heart Journal Plus: Cardiology Research and Practice.2023; 26: 100252.     CrossRef
  • Causal association between vitamin D and diabetic neuropathy: a Mendelian randomization analysis
    Wei Huang, Lei Gu, Jingwen Wang, Yiqi Wang, Fangzheng Cao, Tianyu Jin, Yifan Cheng
    Endocrine.2023; 80(2): 328.     CrossRef
  • Diabetes Mellitus and Heart Failure: Epidemiology, Pathophysiologic Mechanisms, and the Role of SGLT2 Inhibitors
    Panagiotis Theofilis, Evangelos Oikonomou, Konstantinos Tsioufis, Dimitris Tousoulis
    Life.2023; 13(2): 497.     CrossRef
  • Sex differences and sex steroids influence on the presentation and severity of cardiovascular autonomic neuropathy of patients with type 1 diabetes
    Lía Nattero-Chávez, María Insenser, Alejandra Quintero Tobar, Elena Fernández-Durán, Beatriz Dorado Avendaño, Tom Fiers, Jean-Marc Kaufman, Manuel Luque-Ramírez, Héctor F. Escobar-Morreale
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Early Gastrointestinal Neuropathy Assessed by Wireless Motility Capsules in Adolescents with Type 1 Diabetes
    Vinni Faber Rasmussen, Mathilde Thrysøe, Páll Karlsson, Esben Thyssen Vestergaard, Kurt Kristensen, Ann-Margrethe Rønholt Christensen, Jens Randel Nyengaard, Astrid Juhl Terkelsen, Christina Brock, Klaus Krogh
    Journal of Clinical Medicine.2023; 12(5): 1925.     CrossRef
  • Heart rate variability in people with metabolic syndrome
    Kostiantyn Apykhtin, Svitlana Drozdovska, Olha Hurenko, Anastasiia Nahorna, Anatoly Pisaruk, Yuliia Panchenko, Olena Andrieieva
    Ageing & Longevity.2023; (1 2023): 1.     CrossRef
  • Heart rate variability in people with metabolic syndrome
    Kostiantyn Apykhtin, Svitlana Drozdovska, Olha Hurenko, Anastasiia Nahorna, Anatoly Pisaruk, Yuliia Panchenko, Olena Andrieieva
    JOURNAL OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE.2023; (1 2023): 1.     CrossRef
  • Potential of electronic devices for detection of health problems in older adults at home: A systematic review and meta-analysis
    Yu-ting Cao, Xin-xin Zhao, Yi-ting Yang, Shi-jie Zhu, Liang-dong Zheng, Ting Ying, Zhou Sha, Rui Zhu, Tao Wu
    Geriatric Nursing.2023; 51: 54.     CrossRef
  • Diabetes mellitus in der Akut- und Notfallmedizin
    Leo Benning, Julian Krehl, Felix Patricius Hans
    Notfallmedizin up2date.2023; 18(01): 45.     CrossRef
  • Correlation between Heart rate recovery and Left Atrial phasic functions evaluated by 2D speckle-tracking Echocardiography after Acute Myocardial infarction
    Behruz Mashayekhi, Reza Mohseni-Badalabadi, Ali Hosseinsabet, Tahereh Ahmadian
    BMC Cardiovascular Disorders.2023;[Epub]     CrossRef
  • Pancreatic sympathetic innervation disturbance in type 1 diabetes
    Senlin Li, Huimin Yuan, Keshan Yang, Qing Li, Ming Xiang
    Clinical Immunology.2023; 250: 109319.     CrossRef
  • A Nonrandomized Trial of the Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in Type 2 Diabetic Subjects
    Jose A. Adams, Jose R. Lopez, Veronica Banderas, Marvin A. Sackner, Mark Yorek
    Journal of Diabetes Research.2023; 2023: 1.     CrossRef
  • Evaluating treatment options for cardiovascular autonomic neuropathy in patients with diabetes mellitus: a systematic review
    Jasmine KaiLi Goh, Leroy Koh
    Diabetology International.2023; 14(3): 224.     CrossRef
  • Autonomic neuropathic symptoms in patients with diabetes: practical tools for screening in daily routine
    Ana Raquel Souza de Azevedo Vieira, Lara Benigno Porto-Dantas, Flaviene Alves do Prado Romani, Patrícia Souza Carvalho, Rodica Pop-Busui, Hermelinda Cordeiro Pedrosa
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • “Arterial stiffness is not associated with changes in the circadian pattern of blood pressure in patients with type 1 diabetes mellitus and cardiovascular autonomic dysfunction”
    Lía Nattero-Chávez, Ane Bayona Cebada, Elena Fernández-Durán, Alejandra Quintero Tobar, Beatriz Dorado Avendaño, Héctor Escobar-Morreale, Manuel Luque-Ramírez
    Diabetes and Vascular Disease Research.2023; 20(3): 147916412311736.     CrossRef
  • Frontiers in diagnostic and therapeutic approaches in diabetic sensorimotor neuropathy (DSPN)
    Sanjeev Sharma, Gerry Rayman
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • In Type 2 Diabetes Mellitus, normalization of hemoglobin A1c accompanies reduced sensitivity to pressure at the sternum
    Jens Faber, Søren Ballegaard, Nanna Ørsted, Ebbe Eldrup, Benny Karpatschof, Finn Gyntelberg, Sofie Korsgaard Hecquet, Albert Gjedde
    Frontiers in Neuroscience.2023;[Epub]     CrossRef
  • Functional status associated with postural dizziness, but not postural hypotension, in older adults: a community-based study
    Hsiang-Ju Cheng, Zih-Jie Sun, Feng-Hwa Lu, Yi-Ching Yang, Chih-Jen Chang, Jin-Shang Wu
    BMC Geriatrics.2023;[Epub]     CrossRef
  • Effects of baricitinib, empagliflozin, linagliptin and telmisartan on cardiovascular autonomic neuropathy in type 1 diabetes: An exploratory, randomized, open‐label, crossover trial
    Jens Christian Laursen, Viktor Rotbain Curovic, Marjolein Y. A. M. Kroonen, Niels Jongs, Emilie H. Zobel, Tine W. Hansen, Marie Frimodt‐Møller, Gozewijn D. Laverman, Adriaan Kooy, Frederik Persson, Hiddo J. L. Heerspink, Christian Stevns Hansen, Peter Ros
    Diabetes, Obesity and Metabolism.2023; 25(10): 3064.     CrossRef
  • The Retinal Nerve Fiber Layer Thickness Is Associated with Systemic Neurodegeneration in Long-Term Type 1 Diabetes
    Christina Brock, Anne-Marie Wegeberg, Thomas Arendt Nielsen, Bassam Karout, Per M. Hellström, Asbjørn Mohr Drewes, Henrik Vorum
    Translational Vision Science & Technology.2023; 12(6): 23.     CrossRef
  • The Use of Empirical Mode Decomposition on Heart Rate Variability Signals to Assess Autonomic Neuropathy Progression in Type 2 Diabetes
    Sandra Cossul, Felipe Rettore Andreis, Mateus Andre Favretto, Jefferson Luiz Brum Marques
    Applied Sciences.2023; 13(13): 7824.     CrossRef
  • Topical capsaicin for the management of painful diabetic neuropathy: a narrative systematic review
    Brandon Goodwin, Maanas Chiplunkar, Ryan Salerno, Kylon Coombs, Umar Sannoh, Vrushank Shah, Nicholas Averell, Usmaan Al-Shebab, Deanna Janora
    Pain Management.2023; 13(5): 309.     CrossRef
  • Adynamic response to cold pain reflects dysautonomia in type 1 diabetes and polyneuropathy
    Thomas Arendt Nielsen, Søren Lundbye-Christensen, Yoanna Krasimirova Dimitrova, Sam Riahi, Birgitte Brock, Asbjørn Mohr Drewes, Christina Brock
    Scientific Reports.2023;[Epub]     CrossRef
  • Autonomic Nerve Function Tests in Patients with Diabetes
    Heung Yong Jin, Tae Sun Park
    The Journal of Korean Diabetes.2023; 24(2): 71.     CrossRef
  • Understanding the role of hyperglycemia and the molecular mechanism associated with diabetic neuropathy and possible therapeutic strategies
    Mandeep Kaur, Sakshi Misra, Priyanka Swarnkar, Preeti Patel, Balak Das Kurmi, Ghanshyam Das Gupta, Amrita Singh
    Biochemical Pharmacology.2023; 215: 115723.     CrossRef
  • A three-month physical training program improves cardiovascular autonomic function in patients with metabolic syndrome with and without diabetes – a pilot study
    Anna Vágvölgyi, Judit Erzsébet Ábrahám, Éva Máthéné Köteles, Andrea Korom, Mária Barnai, Mónika Szűcs, Andrea Orosz, Péter Kempler, Adrienn Menyhárt, Attila Nemes, Tamás Várkonyi, István Baczkó, István Kósa, Csaba Lengyel
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Cardiovascular autonomic neuropathy in patients with type 2 diabetes with and without sensorimotor polyneuropathy
    Emil Peters, Mustapha Itani, Alexander G. Kristensen, Astrid Juhl Terkelsen, Thomas Krøigård, Hatice Tankisi, Troels S. Jensen, Nanna B. Finnerup, Sandra Sif Gylfadottir
    Journal of the Peripheral Nervous System.2023; 28(3): 450.     CrossRef
  • Cardiac Autonomic Neuropathy in Prediabetes: A Case-Control Study
    Pavan Gujjar, Y. S. Ravikumar, Lakshmi Nagendra, Hiya Boro, Saptarshi Bhattacharya
    Indian Journal of Endocrinology and Metabolism.2023; 27(4): 325.     CrossRef
  • Diabetic Neuropathies
    Melissa A. Elafros, Brian C. Callaghan
    CONTINUUM: Lifelong Learning in Neurology.2023; 29(5): 1401.     CrossRef
  • Determinants of the heart rate variability in type 1 diabetes mellitus
    Máté Hajdu, Konstandia Garmpis, Vivien Vértes, Noémi Vorobcsuk-Varga, Gergő Attila Molnár, László Hejjel, István Wittmann, Réka Faludi
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • The Effect of Exercise on Cardiovascular Autonomic Nervous Function in Patients with Diabetes: A Systematic Review
    Hidetaka Hamasaki
    Healthcare.2023; 11(19): 2668.     CrossRef
  • Influence of Fibrinogen/Albumin Ratio and Fibrinogen/Pre-Albumin Ratio on Cardiac Autonomic Neuropathy in Type 2 Diabetes
    Subei Zhao, Zheng Yang, Meng Yu, Linyu Xiang, Yuhuan Lv, Chunyan Tian, Rong Li
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 3249.     CrossRef
  • In Ischemic Heart Disease, Reduced Sensitivity to Pressure at the Sternum Accompanies Lower Mortality after Five Years: Evidence from a Randomized Controlled Trial
    Søren Ballegaard, Jens Faber, Christian Selmer, Finn Gyntelberg, Svend Kreiner, Benny Karpatschof, Tobias Wirenfeldt Klausen, Åke Hjalmarson, Albert Gjedde
    Journal of Clinical Medicine.2023; 12(24): 7585.     CrossRef
  • Assessment of the relationship of systemic vascular dysfunction and cardiac autonomic neuropathy (CAN) with diabetic retinopathy
    KJ Hari Prakash, Sucheta Parija, Manisha Kar
    Journal of Family Medicine and Primary Care.2023; 12(12): 3236.     CrossRef
  • Autonomic Neuropathy in Ambulatory Type 2 Diabetes Mellitus Patients: A Single-arm Prospective, Observational Study
    Kaustav Saha, Shatavisa Mukherjee, Animesh Maiti, Santanu Kumar Tripathi
    Journal of the Practice of Cardiovascular Sciences.2023; 9(3): 178.     CrossRef
  • Insomnia and type 2 diabetes: how to help the patient. Modern view of a neurologist
    E. S. Akarachkova, O. V. Kotova, V. L. Klimov, D. I. Lebedeva
    FOCUS. Endocrinology.2023; 4(4): 12.     CrossRef
  • Impaired Cardiovagal Activity as a Link Between Hyperglycemia and Arterial Stiffness in Adults With Type 2 Diabetes Mellitus Patients Among an Eastern Indian Population: A Cross-sectional Study
    Nibedita Priyadarsini, Devineni Likhitha, Madumathy Ramachandran, Kishore Kumar Behera
    Canadian Journal of Diabetes.2023;[Epub]     CrossRef
  • Carvedilol improves heart rate variability indices, biomarkers but not cardiac nerve density in streptozotocin-induced T2DM model of diabetic cardiac autonomic neuropathy
    Olawale Mathias Akinlade, Bamidele Owoyele, Olufemi Ayodele Soladoye
    Journal of Basic and Clinical Physiology and Pharmacology.2022; 33(2): 213.     CrossRef
  • Cardiovascular autonomic responses during head-up tilt test in newly diagnosed type 2 diabetes
    Esteban Jorge-Galarza, Margarita Torres-Tamayo, María del Rocío Martínez-Alvarado, Berenice Peña-Aparicio, Carmen González-Salazar, Juan Reyes-Barrera, Manuel Sierra-Beltrán, Erika Fajardo-Flores, Andrey Kostin, J. Antonio González-Hermosillo
    Irish Journal of Medical Science (1971 -).2022; 191(5): 2077.     CrossRef
  • Cardiovascular autonomic neuropathy and incident diabetic kidney disease in patients with type 2 diabetes
    Ji Eun Jun, Min Sun Choi, Jae Hyeon Kim
    Diabetes Research and Clinical Practice.2022; 184: 109181.     CrossRef
  • Kardiovaskuläre Risiken in der 4.–6. Lebensdekade mit Diabetes mellitus Typ 1
    Young Hee Lee-Barkey, Bernd Stratmann, Diethelm Tschöpe
    Der Diabetologe.2022; 18(2): 131.     CrossRef
  • Mechanisms of cardiac dysfunction in diabetic cardiomyopathy: molecular abnormalities and phenotypical variants
    Francesca Romana Prandi, Isabella Evangelista, Domenico Sergi, Alberto Palazzuoli, Francesco Romeo
    Heart Failure Reviews.2022; 28(3): 597.     CrossRef
  • Comparison of Risk Assessment Strategies for Patients with Diabetes Mellitus and Stable Chest Pain: A Coronary Computed Tomography Angiography Study
    Jia Zhao, Shuo Wang, Pengyu Zhao, Yong Huo, Chunjie Li, Jia Zhou, Pawel Kleczynski
    Journal of Diabetes Research.2022; 2022: 1.     CrossRef
  • BOND study: a randomised double-blind, placebo-controlled trial over 12 months to assess the effects of benfotiamine on morphometric, neurophysiological and clinical measures in patients with type 2 diabetes with symptomatic polyneuropathy
    Gidon J Bönhof, Gundega Sipola, Alexander Strom, Christian Herder, Klaus Strassburger, Birgit Knebel, Claudia Reule, Jan-Christoph Wollmann, Andrea Icks, Hadi Al-Hasani, Michael Roden, Oliver Kuss, Dan Ziegler
    BMJ Open.2022; 12(2): e057142.     CrossRef
  • Pragmatic Clinic-Based Investigation of Glycemic Variability in Patients With Type 1 Diabetes in Routine Clinical Practice and Its Association With Cardiovascular Autonomic Neuropathy: A Pilot Study
    Lucianne R.M. Tannus, Marilia B. Gomes
    Endocrine Practice.2022; 28(5): 465.     CrossRef
  • Longitudinal effects of one‐leg standing time on neuropathy outcomes in association with glycemic control in non‐elderly patients with type 2 diabetes
    Kazuhiro Sugimoto, Takashi Sozu, Takehiko Hoshino, Yuko Watanabe, Akira Tamura, Toshiro Yamazaki, Setsu Ohta, Susumu Suzuki, Takuro Shimbo
    Journal of Diabetes Investigation.2022; 13(6): 1039.     CrossRef
  • Thermal quantitative sensory testing as a screening tool for cardiac autonomic neuropathy in patients with diabetes mellitus
    Veronika Potockova, Sarka Mala, Lucie Hoskovcova, Vaclav Capek, Tomas Nedelka, Lucie Riedlbauchova, Daniel Baumgartner, Livie Mensova, Radim Mazanec
    Brain and Behavior.2022;[Epub]     CrossRef
  • Cardiovascular Autonomic Reflex Tests and 7 Heart Rate Variability Indices for Early Diagnosis of Cardiovascular Autonomic Neuropathy in Type 2 Diabetes Individuals
    Yeelen Ballesteros Atala, Mozânia Reis De Matos, Denise Engelbrecht Zantut-Wittmann, Alejandro Rosell Castillo, Daniele P Santos-Bezerra, Maria Lucia Correa-Giannella, Maria Cândida Ribeiro Parisi
    Current Diabetes Reviews.2022;[Epub]     CrossRef
  • Design, synthesis, in vitro and in silico studies of naproxen derivatives as dual lipoxygenase and α-glucosidase inhibitors
    Asma Sardar, Obaid-ur-Rahman Abid, Saima Daud, M. Fakhar-e-Alam, Muhammad Hussnain Siddique, Muhammad Ashraf, Wardah Shahid, Syeda Abida Ejaz, M. Atif, Shafiq Ahmad, Sulman Shafeeq, Muhammad Afzal
    Journal of Saudi Chemical Society.2022; 26(3): 101468.     CrossRef
  • Clinical manifestations and evaluation of cardiac autonomic neuropathy in diabetes mellitus and metabolic syndrome
    L. S. Moshkhoeva, A. N. Barinov
    Neurology, Neuropsychiatry, Psychosomatics.2022; 14(2): 71.     CrossRef
  • The relationship between vitamin B12 levels and electrocardiographic ventricular repolarization markers
    Emre Yılmaz, Devrim Kurt, Aslı Vural, Ertan Aydın, Sencer Çamcı, Ercan Aydın
    Nutrición Hospitalaria.2022;[Epub]     CrossRef
  • The effect of liraglutide on cardiac autonomic function in type 2 diabetes: A prespecified secondary analysis from the LIRAFLAME randomized, double‐blinded, placebo‐controlled trial
    Suvanjaa Sivalingam, Emilie Hein Zobel, Christian S. Hansen, Rasmus S. Ripa, Bernt J. von Scholten, Viktor Rotbain Curovic, Andreas Kjaer, Jacob K. Jensen, Tine W. Hansen, Peter Rossing
    Diabetes, Obesity and Metabolism.2022; 24(8): 1638.     CrossRef
  • Heart Rate Variability and Chronic Kidney Disease in Patients with Type 2 Diabetes
    Wei Shi, Jing Zhang, Dan Chen, Xiaolei Chen, Wei Duan, Hongmei Zhang, Fahd Abd Algalil
    Applied Bionics and Biomechanics.2022; 2022: 1.     CrossRef
  • Spectrum of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: A North India perspective
    PrativaPriyadarshani Sethi, Basavraj Jatteppanavar, Ravi Kant, Monika Pathania, MukeshChand Bairwa
    Journal of Cardio-diabetes and metabolic disorders.2022; 2(1): 23.     CrossRef
  • Cardiac Autonomic Dysfunction Is Associated With Risk of Diabetic Kidney Disease Progression in Type 2 Diabetes Mellitus
    Haixia Zeng, Jianmo Liu, Zheng Chen, Peng Yu, Jianping Liu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Diagnostic Tools, Biomarkers, and Treatments in Diabetic polyneuropathy and Cardiovascular Autonomic Neuropathy
    Gidon J. Bönhof, Christian Herder, Dan Ziegler
    Current Diabetes Reviews.2022;[Epub]     CrossRef
  • Triglyceride glucose index is related with cardiac autonomic dysfunction in patients with metabolic syndrome
    Akif Serhat Balcıoğlu, Ekrem Aksu, Ahmet Çağrı Aykan
    Kardiologiia.2022; 62(6): 45.     CrossRef
  • Pathogenesis of Distal Symmetrical Polyneuropathy in Diabetes
    Sasha Smith, Pasha Normahani, Tristan Lane, David Hohenschurz-Schmidt, Nick Oliver, Alun Huw Davies
    Life.2022; 12(7): 1074.     CrossRef
  • Correlation between impaired hemodynamic response and cardiopulmonary fitness in middle-aged type 2 diabetes mellitus patients: a case–control study
    Jinjin Xie, Lianhua Yin, Jia Huang, Ying Xu, Yannan Chen, Jiawei Qin, Zhizhen Liu, Jing Tao
    European Journal of Applied Physiology.2022; 122(10): 2295.     CrossRef
  • Higher frequency of cardiovascular autonomic neuropathy in youth with type 2 compared to type 1 diabetes: Role of cardiometabolic risk factors
    Benjamin J. Varley, Megan L. Gow, Yoon Hi Cho, Paul Benitez‐Aguirre, Janine Cusumano, Alison Pryke, Albert Chan, Vallimayil Velayutham, Kim C. Donaghue, Maria E. Craig
    Pediatric Diabetes.2022; 23(7): 1073.     CrossRef
  • The role of protein kinase C in diabetic microvascular complications
    Deng Pan, Lin Xu, Ming Guo
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Effect of SGLT-2 inhibitors on cardiac autonomic function in type 2 diabetes mellitus: a meta-analysis of randomized controlled trials
    Dimitrios Patoulias, Alexandra Katsimardou, Nikolaos Fragakis, Christodoulos Papadopoulos, Michael Doumas
    Acta Diabetologica.2022; 60(1): 1.     CrossRef
  • Association between blood glucose levels and autonomic symptoms in Peru
    Gabriel Angeles-Zurita, Margorie Narro-Fuentes, Antonio Bernabe-Ortiz
    Primary Care Diabetes.2022; 16(5): 709.     CrossRef
  • Clinical scoring systems for the risk of cardiovascular autonomic neuropathy in type 1 and type 2 diabetes: A simple tool
    Marika Menduni, Cinzia D'Amato, Martina Leoni, Valentina Izzo, Mariateresa Staltari, Carla Greco, Andrea Abbatepassero, Giuseppe Seminara, Ilenia D'Ippolito, Davide Lauro, Vincenza Spallone
    Journal of the Peripheral Nervous System.2022; 27(4): 259.     CrossRef
  • Vagus nerve stimulation as a novel treatment for systemic lupus erythematous: study protocol for a randomised, parallel-group, sham-controlled investigator-initiated clinical trial, the SLE-VNS study
    Amanda Hempel Zinglersen, Ida Lynghøj Drange, Katrine Aagaard Myhr, Andreas Fuchs, Mogens Pfeiffer-Jensen, Christina Brock, Søren Jacobsen
    BMJ Open.2022; 12(9): e064552.     CrossRef
  • To the interpretation of frequency components of the heart rate variability
    N. V. Kuzmenko, V. A. Tsyrlin, M. G. Pliss
    Translational Medicine.2022; 9(3): 35.     CrossRef
  • Protein pyrrole adducts are associated with elevated glucose indices and clinical features of diabetic diffuse neuropathies
    Xiao Chen, Zhuyi Jiang, Lianjing Zhang, Wei Liu, Xiaohu Ren, Luling Nie, Desheng Wu, Zhiwei Guo, Weimin Liu, Xifei Yang, Yan Wu, Zhen Liang, Peter Spencer, Jianjun Liu
    Journal of Diabetes.2022; 14(10): 646.     CrossRef
  • Cardiac Autonomic Neuropathy in Type 1 and 2 Diabetes: Epidemiology, Pathophysiology, and Management
    Scott Williams, Siddig Abdel Raheim, Muhammad Ilyas Khan, Umme Rubab, Prathap Kanagala, Sizheng Steven Zhao, Anne Marshall, Emily Brown, Uazman Alam
    Clinical Therapeutics.2022; 44(10): 1394.     CrossRef
  • Pathophysiological and clinical aspects of the circadian rhythm of arterial stiffness in diabetes mellitus: A minireview
    Victoria A. Serhiyenko, Ludmila M. Serhiyenko, Volodymyr B. Sehin, Alexandr A. Serhiyenko
    Endocrine Regulations.2022; 56(4): 284.     CrossRef
  • Heart rate-corrected QT interval prolongation is associated with decreased heart rate variability in patients with type 2 diabetes
    Seon-Ah Cha
    Medicine.2022; 101(45): e31511.     CrossRef
  • Effect of the Glucagon-Like Peptide-1 Receptor Agonists on Autonomic Function in Subjects with Diabetes: A Systematic Review and Meta-Analysis
    Carla Greco, Daniele Santi, Giulia Brigante, Chiara Pacchioni, Manuela Simoni
    Diabetes & Metabolism Journal.2022; 46(6): 901.     CrossRef
  • Diabetes-Induced Cardiac Autonomic Neuropathy: Impact on Heart Function and Prognosis
    Susumu Z. Sudo, Tadeu L. Montagnoli, Bruna de S. Rocha, Aimeé D. Santos, Mauro P. L. de Sá, Gisele Zapata-Sudo
    Biomedicines.2022; 10(12): 3258.     CrossRef
  • The Relationship Between Orthostatic Hypotension and Vitamin D Deficiency in Patients with Uncontrolled Type 2 Diabetes Mellitus
    Ece YİĞİT, Ridvan SİVRİTEPE, Dilay KARABULUT, Umut KARABULUT
    Online Türk Sağlık Bilimleri Dergisi.2022; 7(2): 313.     CrossRef
  • A study of heart rate variability in diabetic mellitus patients
    Srinivasa Jayachandra, Satyanath Reddy Kodidala
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2022; 18(3): 153.     CrossRef
  • The prevalence of cardiac autonomic neuropathy in prediabetes: a systematic review
    Aikaterini Eleftheriadou, Scott Williams, Sarah Nevitt, Emily Brown, Rebecca Roylance, John P. H. Wilding, Daniel J. Cuthbertson, Uazman Alam
    Diabetologia.2021; 64(2): 288.     CrossRef
  • Risk of cardiac autonomic neuropathy in latent autoimmune diabetes in adults is similar to type 1 diabetes and lower compared to type 2 diabetes: A cross‐sectional study
    Ernesto Maddaloni, Chiara Moretti, Rossella Del Toro, Sara Sterpetti, Maria Vittoria Ievolella, Gabriele Arnesano, Rocky Strollo, Silvia Irina Briganti, Luca D'Onofrio, Paolo Pozzilli, Raffaella Buzzetti
    Diabetic Medicine.2021;[Epub]     CrossRef
  • Effects of lunar cycle on fasting plasma glucose, heart rate and blood pressure in type 2 diabetic patients
    Sutanu Dutta Chowdhury, Subhasish Pramanik, Koena Bhattacharjee, Lakshmi Kanta Mondal
    Chronobiology International.2021; 38(2): 270.     CrossRef
  • Intensive Risk Factor Management and Cardiovascular Autonomic Neuropathy in Type 2 Diabetes: The ACCORD Trial
    Yaling Tang, Hetal Shah, Carlos Roberto Bueno Junior, Xiuqin Sun, Joanna Mitri, Maria Sambataro, Luisa Sambado, Hertzel C. Gerstein, Vivian Fonseca, Alessandro Doria, Rodica Pop-Busui
    Diabetes Care.2021; 44(1): 164.     CrossRef
  • Decreased glomerular filtration rate and increased albuminuria for identification of cardiovascular autonomic neuropathy in subjects with and without diabetes
    Ying-Chuen Lai, Hung-Yuan Li, Yi-Dier Jiang, Tien-Jyun Chang, Lee-Ming Chuang
    Autonomic Neuroscience.2021; 230: 102757.     CrossRef
  • Exposures influencing the developing central autonomic nervous system
    Sarah D. Schlatterer, Adre J. du Plessis
    Birth Defects Research.2021; 113(11): 845.     CrossRef
  • Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial
    Triantafyllos Didangelos, Eleni Karlafti, Evangelia Kotzakioulafi, Eleni Margariti, Parthena Giannoulaki, Georgios Batanis, Solomon Tesfaye, Kοnstantinos Kantartzis
    Nutrients.2021; 13(2): 395.     CrossRef
  • The Association Between Continuous Glucose Monitoring-Derived Metrics and Cardiovascular Autonomic Neuropathy in Outpatients with Type 2 Diabetes
    Min Young Kim, Gyuri Kim, Ji Yun Park, Min Sun Choi, Ji Eun Jun, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
    Diabetes Technology & Therapeutics.2021; 23(6): 434.     CrossRef
  • Insulin resistance is independently associated with cardiovascular autonomic neuropathy in type 2 diabetes
    Yingshan Liu, Yu Peng, Jing Jin, Yanshan Chen, Chuna Chen, Zhenguo Chen, Haishan Huang, Lingling Xu
    Journal of Diabetes Investigation.2021; 12(9): 1651.     CrossRef
  • SGLT2 inhibitors and the autonomic nervous system in diabetes: A promising challenge to better understand multiple target improvement
    Vincenza Spallone, Paul Valensi
    Diabetes & Metabolism.2021; 47(4): 101224.     CrossRef
  • Reduction of Pressure Pain Sensitivity as Novel Non-pharmacological Therapeutic Approach to Type 2 Diabetes: A Randomized Trial
    Jens Faber, Ebbe Eldrup, Christian Selmer, Caroline Pichat, Sofie Korsgaard Hecquet, Torquil Watt, Svend Kreiner, Benny Karpatschof, Finn Gyntelberg, Søren Ballegaard, Albert Gjedde
    Frontiers in Neuroscience.2021;[Epub]     CrossRef
  • Relationship between cardiac autonomic neuropathy and cardio-metabolic risk profile in adults with type 1 diabetes
    M. Serdarova, R. Dimova, N. Chakarova, G. Grozeva, A. Todorova, T. Tankova
    Diabetes Research and Clinical Practice.2021; 174: 108721.     CrossRef
  • Differences and Similarities in Neuropathy in Type 1 and 2 Diabetes: A Systematic Review
    Mar Sempere-Bigorra, Iván Julián-Rochina, Omar Cauli
    Journal of Personalized Medicine.2021; 11(3): 230.     CrossRef
  • Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives
    Ditte S. Kornum, Astrid J. Terkelsen, Davide Bertoli, Mette W. Klinge, Katrine L. Høyer, Huda H. A. Kufaishi, Per Borghammer, Asbjørn M. Drewes, Christina Brock, Klaus Krogh
    Journal of Clinical Medicine.2021; 10(7): 1392.     CrossRef
  • Diabetic heart disease: A clinical update
    Jake Rajbhandari, Cornelius James Fernandez, Mayuri Agarwal, Beverly Xin Yi Yeap, Joseph M Pappachan
    World Journal of Diabetes.2021; 12(4): 383.     CrossRef
  • Novel and Emerging Electrophysiological Biomarkers of Diabetic Neuropathy and Painful Diabetic Neuropathy
    Anne Marshall, Uazman Alam, Andreas Themistocleous, Nigel Calcutt, Andrew Marshall
    Clinical Therapeutics.2021; 43(9): 1441.     CrossRef
  • Cardiac Autonomic Neuropathy Is Not Reversed by Euglycemia Following Islet Transplantation
    Tejas Deshmukh, Peter Emerson, Patricia Anderson, Eddy Kizana, Philip J. O’Connell, D. Jane Holmes-Walker, James J.H. Chong
    Transplantation.2021; 105(5): 1125.     CrossRef
  • Attenuation of Muscle Mass and Density Is Associated With Poor Outcomes Among Patients Undergoing Major Gynecologic Surgery: A Retrospective Cohort Study
    Lu Che, Yan Zhang, Jiawen Yu, Li Xu, Yuguang Huang
    Anesthesia & Analgesia.2021; 132(6): 1692.     CrossRef
  • Association of Urinary N-Acetyl-β-D-Glucosaminidase with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes Mellitus without Nephropathy
    Min Sun Choi, Ji Eun Jun, Sung Woon Park, Jee Hee Yoo, Jiyeon Ahn, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Moon-Kyu Lee, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2021; 45(3): 349.     CrossRef
  • Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy
    Gordon Sloan, Dinesh Selvarajah, Solomon Tesfaye
    Nature Reviews Endocrinology.2021; 17(7): 400.     CrossRef
  • Heart Rate Variability as a Potential Non-invasive Marker of Blood Glucose Level
    L. R. Jarman, J. L. Elliott, T. Lees, R. Clifton-Bligh, A. M. Simpson, N. Nassif, S. Lal
    Human Physiology.2021; 47(2): 209.     CrossRef
  • Cardiovascular autonomic neuropathy in diabetes: Pathophysiology, clinical assessment and implications
    Alice Duque, Mauro Felippe Felix Mediano, Andrea De Lorenzo, Luiz Fernando Rodrigues Jr
    World Journal of Diabetes.2021; 12(6): 855.     CrossRef
  • Gaussian process-based kernel as a diagnostic model for prediction of type 2 diabetes mellitus risk using non-linear heart rate variability features
    R. Shashikant, Uttam Chaskar, Leena Phadke, Chetankumar Patil
    Biomedical Engineering Letters.2021; 11(3): 273.     CrossRef
  • Possible Preventative/Rehabilitative Role of Gliflozins in OSA and T2DM. A Systematic Literature Review-Based Hypothesis
    Vincenzo Maria Monda, Francesca Porcellati, Felice Strollo, Alessandro Fucili, Marcello Monesi, Ersilia Satta, Sandro Gentile
    Advances in Therapy.2021; 38(8): 4195.     CrossRef
  • Characteristics of cardiovascular autonomic dysfunction and association with quality of life in patients with systemic lupus erythematosus
    Amanda Hempel Zinglersen, Katrine Kjær Iversen, Henrik Christian Bidstrup Leffers, Esben Laugesen, Jesper Fleischer, Søren Jacobsen
    Lupus Science & Medicine.2021; 8(1): e000507.     CrossRef
  • Impaired vagal adaptation to an exercise task in women with gestational diabetes mellitus versus women with uncomplicated pregnancies
    Marieta P. Theodorakopoulou, Areti Triantafyllou, Andreas Zafeiridis, Afroditi Κ. Boutou, Iris Grigoriadou, Evangelia Kintiraki, Stella Douma, Dimitrios G. Goulis, Konstantina Dipla
    Hormones.2021; 20(4): 753.     CrossRef
  • Cardioprotective Effects of Sodium-glucose Cotransporter 2 Inhibitors Regardless of Type 2 Diabetes Mellitus: A Meta-analysis
    Lucas Silva Sousa, Felipe de Araújo Nascimento, Juliano Rocha, Michelle Rocha-Parise
    International Journal of Cardiovascular Sciences.2021;[Epub]     CrossRef
  • Management of diabetic neuropathy
    Simona Cernea, Itamar Raz
    Metabolism.2021; 123: 154867.     CrossRef
  • Large fibre, small fibre and autonomic neuropathy in adolescents with type 1 diabetes: A systematic review
    Vinni Faber Rasmussen, Troels Staehelin Jensen, Hatice Tankisi, Páll Karlsson, Esben Thyssen Vestergaard, Kurt Kristensen, Jens Randel Nyengaard, Astrid Juhl Terkelsen
    Journal of Diabetes and its Complications.2021; 35(11): 108027.     CrossRef
  • Cardiovascular Risk Management in Type 1 Diabetes
    I. H. Teoh, P. Elisaus, J. D. Schofield
    Current Diabetes Reports.2021;[Epub]     CrossRef
  • Disturbances in the intraventricular conduction system in teenagers with type 1 diabetes. A pilot study
    Agnieszka Zubkiewicz-Kucharska, Anna Noczyńska, Małgorzata Sobieszczańska, Małgorzata Poręba, Joanna Chrzanowska, Rafał Poręba, Monika Seifert, Anna Janocha, Krystyna Laszki-Szcząchor
    Journal of Diabetes and its Complications.2021; 35(11): 108043.     CrossRef
  • Peripheral and Autonomic Neuropathy Status of Young Patients With Type 1 Diabetes Mellitus at the Time of Transition From Pediatric Care to Adult-Oriented Diabetes Care
    Anna Vágvölgyi, Ágnes Maróti, Mónika Szűcs, Csongor Póczik, Dóra Urbán-Pap, István Baczkó, Attila Nemes, Éva Csajbók, Krisztián Sepp, Péter Kempler, Andrea Orosz, Tamás Várkonyi, Csaba Lengyel
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Pancreatic exocrine insufficiency in diabetes is associated with autonomic dysfunction
    Dag André Sangnes, Elisabeth Sandvik Bergmann, Rose Marie Moss, Trond Engjom, Eirik Søfteland
    Scandinavian Journal of Gastroenterology.2021; 56(10): 1222.     CrossRef
  • Dependence of Heart Rate Variability Indices on the Mean Heart Rate in Women with Well-Controlled Type 2 Diabetes
    Adriana Robles-Cabrera, José M. Torres-Arellano, Ruben Fossion, Claudia Lerma
    Journal of Clinical Medicine.2021; 10(19): 4386.     CrossRef
  • Normative data on cardiovascular autonomic function in Greenlandic Inuit
    Marie Mathilde Bjerg Christensen, Christian Stevns Hansen, Jesper Fleischer, Dorte Vistisen, Stine Byberg, Trine Larsen, Jens Christian Laursen, Marit Eika Jørgensen
    BMJ Open Diabetes Research & Care.2021; 9(1): e002121.     CrossRef
  • What Is in the Field for Genetics and Epigenetics of Diabetic Neuropathy: The Role of MicroRNAs
    V. Spallone, C. Ciccacci, A. Latini, P. Borgiani, Karim Gariani
    Journal of Diabetes Research.2021; 2021: 1.     CrossRef
  • Evaluation and treatment of peripheral nervous system dysfunction in patients with prediabetes
    O. E. Zinovyeva, T. M. Ostroumova, M. V. Koniashova, N. A. Gorbachev
    Neurology, Neuropsychiatry, Psychosomatics.2021; 13(5): 116.     CrossRef
  • Manifestazioni cliniche della neuropatia autonomica diabetica: valutazione dei sintomi
    Carla Greco, Chiara Pacchioni, Manuela Simoni
    L'Endocrinologo.2021; 22(6): 514.     CrossRef
  • Perspectives of glycemic variability in diabetic neuropathy: a comprehensive review
    Xiaochun Zhang, Xue Yang, Bao Sun, Chunsheng Zhu
    Communications Biology.2021;[Epub]     CrossRef
  • The Association Between Cardiovascular Autonomic Function and Changes in Kidney and Myocardial Function in Type 2 Diabetes and Healthy Controls
    Jens Christian Laursen, Ida Kirstine B. Rasmussen, Emilie H. Zobel, Philip Hasbak, Bernt Johan von Scholten, Lene Holmvang, Rasmus S. Ripa, Christian S. Hansen, Marie Frimodt-Moeller, Andreas Kjaer, Peter Rossing, Tine W. Hansen
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Dependence of heart rate variability on indicators of type 1 diabetes mellitus control.
    N. O. Pertseva, O. V. Gurzhiy, K. I. Moshenets
    Medicni perspektivi (Medical perspectives).2020; 25(1): 88.     CrossRef
  • Efficacy and safety of evogliptin treatment in patients with type 2 diabetes: A multicentre, active‐controlled, randomized, double‐blind study with open‐label extension (the EVERGREEN study)
    Gyuri Kim, Soo Lim, Hyuk‐Sang Kwon, Ie B. Park, Kyu J. Ahn, Cheol‐Young Park, Su K. Kwon, Hye S. Kim, Seok W. Park, Sin G. Kim, Min K. Moon, Eun S. Kim, Choon H. Chung, Kang S. Park, Mikyung Kim, Dong J. Chung, Chang B. Lee, Tae H. Kim, Moon‐Kyu Lee
    Diabetes, Obesity and Metabolism.2020; 22(9): 1527.     CrossRef
  • Diabetes mellitus and comorbidities: A bad romance
    Niki Katsiki, Dimitrios Tousoulis
    Hellenic Journal of Cardiology.2020; 61(1): 23.     CrossRef
  • Features of the glucose influence on the heart activity and the changes in the potentials of the stomach and the intestines at the heart insufficiency conditions
    V. V. Soltanov, L. M. Komarovskaya
    Doklady of the National Academy of Sciences of Belarus.2020; 63(6): 736.     CrossRef
  • Living Day to Day
    Gerald Kayingo, Virginia McCoy Hass
    Physician Assistant Clinics.2020; 5(2): 213.     CrossRef
  • Source specific PM2.5 associated with heart rate variability in the elderly with coronary heart disease: A community-based panel study
    Xi Chen, Bing Qiu, Qinpei Zou, Tian Qiu, Runkui Li, Ashley Truong, Yanmin Qi, Tao Liu, Limin Han, Tiebing Liu, Junrui Chang, Qi Sun, Ying Zhu, Dongqun Xu
    Chemosphere.2020; 260: 127399.     CrossRef
  • The Association of Autonomic Nervous System Function With Ischemic Stroke, and Treatment Strategies
    Mengxi Zhao, Ling Guan, Yilong Wang
    Frontiers in Neurology.2020;[Epub]     CrossRef
  • Cardiac diabetic autonomic neuropathy
    L. T. Akhmedzhanova, T. A. Belyakova, Yu. A. Podkovko, Yu. M. Shor
    Medical Council.2020; (21): 94.     CrossRef
  • Diabetes, and its treatment, as an effector of autonomic nervous system circuits and its functions
    Liliana Espinoza, Carie R Boychuk
    Current Opinion in Pharmacology.2020; 54: 18.     CrossRef
  • Morning blood pressure surge is associated with autonomic neuropathy and peripheral vascular disease in patients with diabetes
    Federica Di Gennaro, Cinzia D’Amato, Roberto Morganti, Carla Greco, Susanna Longo, Diana Corradini, Davide Lauro, Vincenza Spallone
    Journal of Human Hypertension.2020; 34(7): 495.     CrossRef
  • The Compound Expression of HSP90 and INOS in the Testis of Diabetic Rats as Cellular and Pathologic Adverse Effects of Diabetes
    Ali Alsarhan, Kawther Faisal Amawi, Inas Saleh Al-Mazari, Hashem Abu Hurirah, Ahed J. Alkhatib
    Analytical Cellular Pathology.2020; 2020: 1.     CrossRef
  • Heart rate variability features from nonlinear cardiac dynamics in identification of diabetes using artificial neural network and support vector machine
    Yogender Aggarwal, Joyani Das, Papiya Mitra Mazumder, Rohit Kumar, Rakesh Kumar Sinha
    Biocybernetics and Biomedical Engineering.2020; 40(3): 1002.     CrossRef
  • Distal Symmetric and Cardiovascular Autonomic Neuropathies in Brazilian Individuals with Type 2 Diabetes Followed in a Primary Health Care Unit: A Cross-Sectional Study
    Mozania Reis de Matos, Daniele Pereira Santos-Bezerra, Cristiane das Graças Dias Cavalcante, Jacira Xavier de Carvalho, Juliana Leite, Jose Antonio Januario Neves, Sharon Nina Admoni, Marisa Passarelli, Maria Candida Parisi, Maria Lucia Correa-Giannella
    International Journal of Environmental Research and Public Health.2020; 17(9): 3232.     CrossRef
  • Awareness of hypoglycemia and spectral analysis of heart rate variability in type 1 diabetes
    Ticiana Paes, L. Clemente Rolim, Celso Sallum Filho, João Roberto de Sa, Sérgio A. Dib
    Journal of Diabetes and its Complications.2020; 34(8): 107617.     CrossRef
  • Is there cardiac autonomic neuropathy in prediabetes?
    Lindsay A. Zilliox, James W. Russell
    Autonomic Neuroscience.2020; 229: 102722.     CrossRef
  • Chronic Microvascular Complications in Prediabetic States—An Overview
    Angelika Baranowska-Jurkun, Wojciech Matuszewski, Elżbieta Bandurska-Stankiewicz
    Journal of Clinical Medicine.2020; 9(10): 3289.     CrossRef
  • Cardiac vagal tone as a novel screening tool to recognize asymptomatic cardiovascular autonomic neuropathy: Aspects of utility in type 1 diabetes
    Anne-Marie Wegeberg, Elin D Lunde, Sam Riahi, Niels Ejskjaer, Asbjørn M Drewes, Birgitte Brock, Rodica Pop-Busui, Christina Brock
    Diabetes Research and Clinical Practice.2020; 170: 108517.     CrossRef
  • Assessment of baroreceptor reflex sensitivity in young obese Saudi males at rest and in response to physiological challenges
    Abdullah N. AlShahrani, Lubna I. Al‐Asoom, Ahmed A. Alsunni, Nabil S. Elbahai, Talay Yar
    Physiological Reports.2020;[Epub]     CrossRef
  • The relationship between QT interval indices with cardiac autonomic neuropathy in diabetic patients: a case control study
    Maryam Vasheghani, Farzaneh Sarvghadi, Mohammad Reza Beyranvand, Habib Emami
    Diabetology & Metabolic Syndrome.2020;[Epub]     CrossRef
  • Myocardial ischaemia reperfusion injury and cardioprotection in the presence of sensory neuropathy: Therapeutic options
    Péter Bencsik, Kamilla Gömöri, Tamara Szabados, Péter Sántha, Zsuzsanna Helyes, Gábor Jancsó, Péter Ferdinandy, Anikó Görbe
    British Journal of Pharmacology.2020; 177(23): 5336.     CrossRef
  • Biological Activity of c-Peptide in Microvascular Complications of Type 1 Diabetes—Time for Translational Studies or Back to the Basics?
    Aleksandra Ryk, Aleksandra Łosiewicz, Arkadiusz Michalak, Wojciech Fendler
    International Journal of Molecular Sciences.2020; 21(24): 9723.     CrossRef
  • Diabetes and cardiovascular disease: inter-relation of risk factors and treatment
    Aman Sharma, Shweta Mittal, Rohan Aggarwal, Meenakshi K. Chauhan
    Future Journal of Pharmaceutical Sciences.2020;[Epub]     CrossRef
  • Diabetic Autonomic Neuropathy: A Clinical Update
    Jugal Kishor Sharma, Anshu Rohatgi, Dinesh Sharma
    Journal of the Royal College of Physicians of Edinburgh.2020; 50(3): 269.     CrossRef
  • Obesity, Metabolic Syndrome and the Risk of Microvascular Complications in Patients with Diabetes mellitus
    Niki Katsiki, Panagiotis Anagnostis, Kalliopi Kotsa, Dimitrios G. Goulis, Dimitri P. Mikhailidis
    Current Pharmaceutical Design.2019; 25(18): 2051.     CrossRef
  • Cardiac Autonomic Neuropathy in Obesity, the Metabolic Syndrome and Prediabetes: A Narrative Review
    Scott M. Williams, Aikaterini Eleftheriadou, Uazman Alam, Daniel J. Cuthbertson, John P. H. Wilding
    Diabetes Therapy.2019; 10(6): 1995.     CrossRef
Complications
Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis
Yong-ho Lee, Yongin Cho, Byung-Wan Lee, Cheol-Young Park, Dae Ho Lee, Bong-Soo Cha, Eun-Jung Rhee
Diabetes Metab J. 2019;43(1):31-45.   Published online December 17, 2018
DOI: https://doi.org/10.4093/dmj.2019.0011
Correction in: Diabetes Metab J 2019;43(5):731
  • 8,076 View
  • 166 Download
  • 106 Web of Science
  • 100 Crossref
AbstractAbstract PDFPubReader   

Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (including fibrosis) tends to be worsened by the presence of diabetes. NAFLD is considered an emerging risk factor for type 2 diabetes mellitus and a contributor to the development of chronic diabetes-related complications. This reciprocal relationship demonstrates the importance of confirming suspected NAFLD in patients with diabetes. Due to the invasive nature of liver biopsy to assess NAFLD status, various alternative non-invasive modalities have been developed and validated. Here, we summarized the epidemiology of NAFLD in patients with diabetes and reviewed currently available imaging modalities and biomarker-based prediction models for their ability to detect liver steatosis and/or fibrosis.

Citations

Citations to this article as recorded by  
  • Mortality in metabolic dysfunction-associated steatotic liver disease: A nationwide population-based cohort study
    Eugene Han, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Sang Hoon Ahn, Yong-ho Lee, Seung Up Kim
    Metabolism.2024; 152: 155789.     CrossRef
  • Intact ketogenesis predicted reduced risk of moderate-severe metabolic-associated fatty liver disease assessed by liver transient elastography in newly diagnosed type 2 diabetes
    Sejeong Lee, Jaehyun Bae, Seung Up Kim, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • ZJU Index as a Predictive Tool for Diabetes Incidence: Insights from a Population-Based Cohort Study
    Chenjiao Wu, Yi Hao Loh, Hangkai Huang, Chengfu Xu
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 715.     CrossRef
  • Sigmoidal relationship between liver fat content and nonalcoholic fatty liver disease in Chinese adults
    Pingping Yu, Huachao Yang, Hu Li, Ying Mei, Yuanyuan Wu, Hongfeng Cheng, Huiru Su, Yueling Deng, Tao Jiang, Zhongxiang He, Peng Hu
    Postgraduate Medical Journal.2024;[Epub]     CrossRef
  • Safety and Efficacy of Efruxifermin in Combination With a GLP-1 Receptor Agonist in Patients With NASH/MASH and Type 2 Diabetes in a Randomized Phase 2 Study
    Stephen A. Harrison, Juan P. Frias, K. Jean Lucas, Gary Reiss, Guy Neff, Sureka Bollepalli, Yan Su, Doreen Chan, Erik J. Tillman, Ali Moulton, Brittany de Temple, Arian Zari, Reshma Shringarpure, Timothy Rolph, Andrew Cheng, Kitty Yale
    Clinical Gastroenterology and Hepatology.2024;[Epub]     CrossRef
  • Plasma Adiponectin and Its Correlation with Carotid Intima-Media Thickness in Obesity and in Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
    Maha Hussein, Aasem Saif, Mona Amin, Osama Khalafallah, Ahmed Hussien, Samar Aboulsoud, Shrook Mousa, S. Razzaque Mohammed
    Journal of Nutrition and Metabolism.2023; 2023: 1.     CrossRef
  • Exposure to Bisphenol A, S, and F and its Association with Obesity and Diabetes Mellitus in General Adults of Korea: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Min Kyong Moon, Min Joo Kim, Inae Lee, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Young Joo Park, Kyungho Choi
    Exposure and Health.2023; 15(1): 53.     CrossRef
  • Liver fat content assessed by conventional B-mode ultrasound and metabolic profile in non-diabetic patients: Implications for clinical practice
    Rosanna Villani, Grazia Pia Magnati, Giulia Tuccari, Moris Sangineto, Antonino Davide Romano, Tommaso Cassano, Gaetano Serviddio
    Ultrasound.2023; 31(3): 177.     CrossRef
  • Association of cardiovascular health metrics with annual incidence of prediabetes or diabetes: Analysis of a nationwide real‐world database
    Akira Okada, Hidehiro Kaneko, Satoshi Matsuoka, Hidetaka Itoh, Yuta Suzuki, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Satoko Yamaguchi, Koichi Node, Toshimasa Yamauchi, Hideo Yasunaga, Issei Komuro
    Journal of Diabetes Investigation.2023; 14(3): 452.     CrossRef
  • Effects of Environmental Cadmium Exposure on the Liver in Korean Adults: Cross-Sectional and Longitudinal Studies
    Mi-Na Seo, Sang-Yong Eom, Ji-Ae Lim, Jung-Eum Lee, Byung-Sun Choi, Ho-Jang Kwon, Young-Seoub Hong, Heon Kim, Jung-Duck Park
    Archives of Environmental Contamination and Toxicology.2023; 84(2): 237.     CrossRef
  • Newer Glucose-Lowering Therapies in Older Adults with Type 2 Diabetes
    Anika Bilal, Richard E. Pratley
    Endocrinology and Metabolism Clinics of North America.2023; 52(2): 355.     CrossRef
  • CD24 Gene Expression as a Risk Factor for Non-Alcoholic Fatty Liver Disease
    Mona A. Amin, Halla M. Ragab, Nabila Abd El Maksoud, Wafaa Abd Elaziz
    Diagnostics.2023; 13(5): 984.     CrossRef
  • Metabolic Dysfunction-Associated Fatty Liver Disease and Mortality: A Population-Based Cohort Study
    Kyung-Soo Kim, Sangmo Hong, Hong-Yup Ahn, Cheol-Young Park
    Diabetes & Metabolism Journal.2023; 47(2): 220.     CrossRef
  • Non-Alcoholic Fatty Liver Disease with Sarcopenia and Carotid Plaque Progression Risk in Patients with Type 2 Diabetes Mellitus
    Yongin Cho, Hye-Sun Park, Byung Wook Huh, Yong-ho Lee, Seong Ha Seo, Da Hea Seo, Seong Hee Ahn, Seongbin Hong, So Hun Kim
    Diabetes & Metabolism Journal.2023; 47(2): 232.     CrossRef
  • Nonalcoholic fatty liver disease and type 2 diabetes: an observational and Mendelian randomization study
    Yuetian Yu, Yuefeng Yu, Yuying Wang, Yi Chen, Ningjian Wang, Bin Wang, Yingli Lu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • β-sitosterol attenuates high- fat diet-induced hepatic steatosis in rats by modulating lipid metabolism, inflammation and ER stress pathway
    Omayma AR Abo-Zaid, Fatma SM Moawed, Effet Soliman Ismail, Mostafa A. Farrag
    BMC Pharmacology and Toxicology.2023;[Epub]     CrossRef
  • Fatty Liver & Diabetes Statistics in Korea: Nationwide Data 2009 to 2017
    Eugene Han, Kyung-Do Han, Yong-ho Lee, Kyung-Soo Kim, Sangmo Hong, Jung Hwan Park, Cheol-Young Park
    Diabetes & Metabolism Journal.2023; 47(3): 347.     CrossRef
  • Increased expression of sodium-glucose cotransporter 2 and O-GlcNAcylation in hepatocytes drives non-alcoholic steatohepatitis
    Hye Jin Chun, Eun Ran Kim, Minyoung Lee, Da Hyun Choi, Soo Hyun Kim, Eugene Shin, Jin-Hong Kim, Jin Won Cho, Dai Hoon Han, Bong-Soo Cha, Yong-ho Lee
    Metabolism.2023; 145: 155612.     CrossRef
  • Role of vascular endothelial growth factor B in nonalcoholic fatty liver disease and its potential value
    Yu-Qi Li, Lei Xin, Yu-Chi Zhao, Shang-Qi Li, Ya-Nuo Li
    World Journal of Hepatology.2023; 15(6): 786.     CrossRef
  • Increased risk of incident diabetes in patients with MAFLD not meeting the criteria for NAFLD
    So Hee Park, Jiyun Park, So Yoon Kwon, You-Bin Lee, Gyuri Kim, Kyu Yeon Hur, Janghyun Koh, Jae Hwan Jee, Jae Hyeon Kim, Mira Kang, Sang-Man Jin
    Scientific Reports.2023;[Epub]     CrossRef
  • Significance of Diabetic Kidney Disease Biomarkers in Predicting Metabolic-Associated Fatty Liver Disease
    Jaehyun Bae, Byung-Wan Lee
    Biomedicines.2023; 11(7): 1928.     CrossRef
  • An Evidence-Based Review of Diabetes Care: History, Types, Relationship to Cancer and Heart Disease, Co-Morbid Factors, and Preventive Measures
    Umesh Chandra Gupta, Subhas Chandra Gupta, Shayle Sugandh Gupta
    Current Nutrition & Food Science.2023; 19(4): 399.     CrossRef
  • Associations of serum aminotransferase and the risk of all-cause and cause-specific mortality in Chinese type 2 diabetes: a community-based cohort study
    Jian Su, Haoyu Guan, Xikang Fan, Hao Yu, Yu Qin, Jie Yang, Zheng Zhu, Chong Shen, Enchun Pan, Yan Lu, Jin-Yi Zhou, Ming Wu
    BMJ Open.2023; 13(7): e068160.     CrossRef
  • Retinoic acid signaling in fatty liver disease
    Fathima N. Cassim Bawa, Yanqiao Zhang
    Liver Research.2023; 7(3): 189.     CrossRef
  • Pharmaceutical Strategies to Improve Druggability of Potential Drug Candidates in Nonalcoholic Fatty Liver Disease Therapy
    Reeju Amatya, Donghee Lee, Kyoung Ah Min, Meong Cheol Shin
    Pharmaceutics.2023; 15(7): 1963.     CrossRef
  • Prevalence of Non-Alcoholic Fatty Liver Disease and Its Risk Factors in Korean Population
    Sang Gyeong Lee, Songchan Oh, Moon Seong Kim, Jooyeon Kim, Eunjin Jung, Young Jun Kim, Jiyoun Hong
    Food Supplements and Biomaterials for Health.2023;[Epub]     CrossRef
  • Low‑dose ionizing radiation attenuates high glucose‑induced hepatic apoptosis and immune factor release via modulation of a miR‑155‑SOCS1 axis
    Hongqiong Fan, Shanshan Liu, Benzheng Jiao, Xinyue Liang
    Molecular Medicine Reports.2023;[Epub]     CrossRef
  • CT-based measurement of visceral adipose tissue volume as a reliable tool for assessing metabolic risk factors in prediabetes across subtypes
    Jihyun Kim, Keunyoung Kim
    Scientific Reports.2023;[Epub]     CrossRef
  • The Role of the Fatty Liver Index (FLI) in the Management of Non-Alcoholic Fatty Liver Disease: A Systematic Review
    Teodora Biciusca, Sorina Ionelia Stan, Mara Amalia Balteanu, Ramona Cioboata, Alice Elena Ghenea, Suzana Danoiu, Ana-Maria Bumbea, Viorel Biciusca
    Diagnostics.2023; 13(21): 3316.     CrossRef
  • Circ_0004535/miR-1827/CASP8 network involved in type 2 diabetes mellitus with nonalcoholic fatty liver disease
    Min Li, Ai Zeng, Xinle Tang, Hui Xu, Wei Xiong, Yanying Guo
    Scientific Reports.2023;[Epub]     CrossRef
  • Prevalence of High and Moderate Risk of Liver Fibrosis Among Patients With Diabetes at a Noncommunicable Diseases (NCD) Clinic in a Primary Healthcare Center in Northern India
    Anubhav Mondal, Aninda Debnath, Ghurumourthy Dhandapani, Abhishek Sharma, Shveta Lukhmana, Geeta Yadav
    Cureus.2023;[Epub]     CrossRef
  • Therapeutic outcome of dapagliflozin on various parameters in non-alcoholic fatty liver disease (NAFLD) patients
    Mazhar Hussain, Muhammad Zafar Majeed Babar, Saba Tariq, Muhammad Irfan Ahmad, Lubna Akhtar
    International Journal of Diabetes in Developing Countries.2022; 42(2): 290.     CrossRef
  • Lead, mercury, and cadmium exposures are associated with obesity but not with diabetes mellitus: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Min Kyong Moon, Inae Lee, Aram Lee, Hyunwoong Park, Min Joo Kim, Sunmi Kim, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Gi Jeong Cheon, Kyungho Choi, Young Joo Park, Jeongim Park
    Environmental Research.2022; 204: 111888.     CrossRef
  • Association of Prenatal Famine Exposure With Inflammatory Markers and Its Impact on Adulthood Liver Function Across Consecutive Generations
    Shiwei Yan, Jingqi Ruan, Yu Wang, Jiaxu Xu, Changhao Sun, Yucun Niu
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Serum Metabolomics in Patients with Coexisting NAFLD and T2DM Using Liquid Chromatography-Mass Spectrometry
    Cheng Hu, Xiaoyu Zhuang, Jiaqi Zhang, Tao Wang, Shengnan Du, Jinping Wang, Xuelian Peng, Qin Cao, Mingcai Zhang, Yuanye Jiang
    Laboratory Medicine.2022; 53(4): 360.     CrossRef
  • Genistein—Opportunities Related to an Interesting Molecule of Natural Origin
    Ewa Garbiec, Judyta Cielecka-Piontek, Magdalena Kowalówka, Magdalena Hołubiec, Przemysław Zalewski
    Molecules.2022; 27(3): 815.     CrossRef
  • Renal Tubular Damage Marker, Urinary N-acetyl-β-D-Glucosaminidase, as a Predictive Marker of Hepatic Fibrosis in Type 2 Diabetes Mellitus
    Hae Kyung Kim, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
    Diabetes & Metabolism Journal.2022; 46(1): 104.     CrossRef
  • Long-term effects of the changes in hepatic steatosis status on the risk of incident type 2 diabetes mellitus: A 15-year community-based prospective cohort study
    Seung Min Chung, Min Kyu Kang, Jinho Jung, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee, Rohit Loomba, Jung Gil Park, Jun Sung Moon
    Diabetes Research and Clinical Practice.2022; 184: 109208.     CrossRef
  • Prevalence and Risk Factors of Advanced Liver Fibrosis in a Population‐Based Study in Germany
    Yvonne Huber, Andreas Schulz, Irene Schmidtmann, Manfred Beutel, Norbert Pfeiffer, Thomas Münzel, Peter R. Galle, Philipp S. Wild, Karl J. Lackner, Jörn M. Schattenberg
    Hepatology Communications.2022; 6(6): 1457.     CrossRef
  • Non-alcoholic fatty liver disease: Epidemiology, pathophysiology and an update on the therapeutic approaches
    RehabF Abdel-Rahman
    Asian Pacific Journal of Tropical Biomedicine.2022; 12(3): 99.     CrossRef
  • State-of-the-Art Overview of the Pharmacological Treatment of Non-Alcoholic Steatohepatitis
    Yongin Cho, Yong-ho Lee
    Endocrinology and Metabolism.2022; 37(1): 38.     CrossRef
  • Obesity is an important determinant of severity in newly defined metabolic dysfunction-associated fatty liver disease
    Ji Hye Huh, Kwang Joon Kim, Seung Up Kim, Bong-Soo Cha, Byung-Wan Lee
    Hepatobiliary & Pancreatic Diseases International.2022; 21(3): 241.     CrossRef
  • The associations of hepatic steatosis and fibrosis using fatty liver index and BARD score with cardiovascular outcomes and mortality in patients with new-onset type 2 diabetes: a nationwide cohort study
    Jiyun Park, Gyuri Kim, Bong-Sung Kim, Kyung-Do Han, So Yoon Kwon, So Hee Park, You-Bin Lee, Sang-Man Jin, Jae Hyeon Kim
    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • Sociodemographic and genetic determinants of nonalcoholic fatty liver disease in type 2 diabetes mellitus patients
    Muhammad Adnan, Abdul Wajid, Wasif Noor, Andleeb Batool, Muhammad Aasim, Kamran Abbas, Quratul Ain
    Journal of Genetic Engineering and Biotechnology.2022; 20(1): 68.     CrossRef
  • Concordance between indirect fibrosis and steatosis indices and their predictors in subjects with overweight/obesity
    Gaggini Melania, Vigna Luisella, Di Piazza Salvina, Gori Francesca, Tirelli Amedea Silvia, Bamonti Fabrizia, Maltinti Maristella, Napolitano Filomena, Chatzianagnostou Kyriazoula, Cristina Vassalle
    Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2022; 27(7): 2617.     CrossRef
  • Stéatopathie métabolique hépatique évaluée par le FibroScan® avec contrôle des paramètres d’atténuation (CAP) chez la personne diabétique de type 2 en Côte d’Ivoire
    Jacko Abodo, Dimitri Kouamé, Jocelyne Danho, Moumouni Léilatou, Pierre Koffi-Dago, Adelaïde Hué, Assita Yao, Franck Kouassi, Anselme N’Guessan, Fulgence Bathaix
    Médecine des Maladies Métaboliques.2022; 16(6): 550.     CrossRef
  • Non-invasive diagnosis and staging of non-alcoholic fatty liver disease
    Stergios Kechagias, Mattias Ekstedt, Christian Simonsson, Patrik Nasr
    Hormones.2022; 21(3): 349.     CrossRef
  • Association between organochlorine pesticides and nonalcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003–2004
    Hyunji Sang, Kyu-Na Lee, Chang Hee Jung, Kyungdo Han, Eun Hee Koh
    Scientific Reports.2022;[Epub]     CrossRef
  • Increased Risk of NAFLD in Adults with Glomerular Hyperfiltration: An 8-Year Cohort Study Based on 147,162 Koreans
    Dae-Jeong Koo, Mi Yeon Lee, Inha Jung, Sun Joon Moon, Hyemi Kwon, Eun-Jung Rhee, Cheol-Young Park, Won-Young Lee, Ki Won Oh, Se Eun Park
    Journal of Personalized Medicine.2022; 12(7): 1142.     CrossRef
  • Advanced Liver Fibrosis Is Associated with Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease
    Da Hea Seo, Young Ju Suh, Yongin Cho, Seong Hee Ahn, Seongha Seo, Seongbin Hong, Yong-ho Lee, Young Ju Choi, Eunjig Lee, So Hun Kim
    Diabetes & Metabolism Journal.2022; 46(4): 630.     CrossRef
  • New Insights into Non-Alcoholic Fatty Liver Disease and Coronary Artery Disease: The Liver-Heart Axis
    Georgiana-Diana Cazac, Cristina-Mihaela Lăcătușu, Cătălina Mihai, Elena-Daniela Grigorescu, Alina Onofriescu, Bogdan-Mircea Mihai
    Life.2022; 12(8): 1189.     CrossRef
  • Efficacy and mechanism of Jiedu Tongluo Tiaogan Formula in treating type 2 diabetes mellitus combined with non-alcoholic fatty liver disease: Study protocol for a parallel-armed, randomized controlled trial
    Jinghan Xu, Chunli Piao, Yue Qu, Tianjiao Liu, Yuting Peng, Qi Li, Xiaohua Zhao, Pei Li, Xuemin Wu, Yawen Fan, Binqin Chen, Jie Yang
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Ultrasound-Based Hepatic Elastography in Non-Alcoholic Fatty Liver Disease: Focus on Patients with Type 2 Diabetes
    Georgiana-Diana Cazac, Cristina-Mihaela Lăcătușu, Cătălina Mihai, Elena-Daniela Grigorescu, Alina Onofriescu, Bogdan-Mircea Mihai
    Biomedicines.2022; 10(10): 2375.     CrossRef
  • Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats
    Yujie Zhong, Zhiman Li, Ruyi Jin, Yanpeng Yao, Silan He, Min Lei, Xin Wang, Chao Shi, Li Gao, Xiaoli Peng
    Nutrients.2022; 14(23): 4994.     CrossRef
  • The associations between changes in hepatic steatosis and heart failure and mortality: a nationwide cohort study
    Jiyun Park, Gyuri Kim, Hasung Kim, Jungkuk Lee, Sang-Man Jin, Jae Hyeon Kim
    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • Recent advances and potentiality of postbiotics in the food industry: Composition, inactivation methods, current applications in metabolic syndrome, and future trends
    Yujie Zhong, Tao Wang, Ruilin Luo, Jiayu Liu, Ruyi Jin, Xiaoli Peng
    Critical Reviews in Food Science and Nutrition.2022; : 1.     CrossRef
  • Association of nonalcoholic fatty liver disease with coronary artery disease in type 2 diabetes mellitus: A cross-sectional study from a tertiary care medical college hospital
    Neelakandan Ramya, Golepu Karthikeya, SethuPrabhu Shankar
    Acta Medica International.2022; 9(1): 31.     CrossRef
  • NAFLDin type 2 diabetes mellitus: Still many challenging questions
    Simona Cernea, Itamar Raz
    Diabetes/Metabolism Research and Reviews.2021;[Epub]     CrossRef
  • The protective effect of shrimp cooked in different methods on high-cholesterol- induced fatty liver in rats
    Nora A. AlFaris, Ghedeir M. Alshammari, Jozaa Z. AlTamimi, Lujain A. AlMousa, Nora M. AlKehayez, Dalal H. Aljabryn, Reham I. Alagal, Mohammed A. Yahya
    Saudi Journal of Biological Sciences.2021; 28(1): 170.     CrossRef
  • Evolution of liver fibrosis and steatosis markers in patients with type 2 diabetes after metformin treatment for 2 years
    Hye Won Lee, Jae Seung Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim
    Journal of Diabetes and its Complications.2021; 35(1): 107747.     CrossRef
  • Prognostic value of non-alcoholic fatty liver disease for predicting cardiovascular events in patients with diabetes mellitus with suspected coronary artery disease: a prospective cohort study
    Keishi Ichikawa, Toru Miyoshi, Kazuhiro Osawa, Takashi Miki, Hironobu Toda, Kentaro Ejiri, Masatoki Yoshida, Yusuke Nanba, Masashi Yoshida, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito
    Cardiovascular Diabetology.2021;[Epub]     CrossRef
  • Implications of Abdominal Adipose Tissue Distribution on Nonalcoholic Fatty Liver Disease and Metabolic Syndrome: A Chinese General Population Study
    Chileka Chiyanika, Vincent Wai-Sun Wong, Grace Lai-Hung Wong, Henry Lik-Yuen Chan, Steve C. N. Hui, David K. W. Yeung, Winnie C. W. Chu
    Clinical and Translational Gastroenterology.2021; 12(2): e00300.     CrossRef
  • Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: Diagnosis and Treatment
    Sook Jung Lee, Byung-Wan Lee
    The Journal of Korean Diabetes.2021; 22(1): 38.     CrossRef
  • Pioglitazone for NAFLD Patients With Prediabetes or Type 2 Diabetes Mellitus: A Meta-Analysis
    Jingxuan Lian, Jianfang Fu
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway
    In-Jin Cho, Da-Hee Oh, Jin Yoo, You-Cheol Hwang, Kyu Jeung Ahn, Ho-Yeon Chung, Soung Won Jeong, Ju-Young Moon, Sang-Ho Lee, Sung-Jig Lim, In-Kyung Jeong
    Scientific Reports.2021;[Epub]     CrossRef
  • Diabetic Kidney Disease, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease: A New Triumvirate?
    Carolina M. Perdomo, Nuria Garcia-Fernandez, Javier Escalada
    Journal of Clinical Medicine.2021; 10(9): 2040.     CrossRef
  • Fenofibrate, a PPARα agonist, reduces hepatic fat accumulation through the upregulation of TFEB-mediated lipophagy
    Jin Yoo, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung, You-Cheol Hwang
    Metabolism.2021; 120: 154798.     CrossRef
  • Association Between Thyroid Hormone Levels and Advanced Liver Fibrosis in Patients with Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease
    Jing Du, Sanbao Chai, Xin Zhao, Jianbin Sun, Xiaomei Zhang, Lili Huo
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 2399.     CrossRef
  • Association between toothbrushing and non-alcoholic fatty liver disease
    Ji-Youn Kim, Yong-Moon Park, Gyu-Na Lee, Hyun Chul Song, Yu-Bae Ahn, Kyungdo Han, Seung-Hyun Ko, Houkai Li
    PLOS ONE.2021; 16(5): e0243686.     CrossRef
  • Non‐alcoholic fatty liver disease and sarcopenia additively increase mortality: a Korean nationwide survey
    Joon Ho Moon, Bo Kyung Koo, Won Kim
    Journal of Cachexia, Sarcopenia and Muscle.2021; 12(4): 964.     CrossRef
  • Sodium-Glucose Cotransporter-2 Inhibitors Ameliorate Liver Enzyme Abnormalities in Korean Patients With Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease
    Won Euh, Soo Lim, Jin-Wook Kim
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Modulation and bioinformatics screening of hepatic mRNA-lncRNAs (HML) network associated with insulin resistance in prediabetic and exercised mice
    Fatemeh Kazeminasab, Sayed Mohammad Marandi, Maryam Baharlooie, Mohammad Hossein Nasr-Esfahani, Kamran Ghaedi
    Nutrition & Metabolism.2021;[Epub]     CrossRef
  • Liver Fibrosis Indices for the Prediction of Mortality in Korean Subjects: A 16-Year Prospective Cohort Study
    Tae Jung Oh, Kyuho Kim, Jae Hoon Moon, Sung Hee Choi, Nam H Cho, Hak Chul Jang
    Journal of the Endocrine Society.2021;[Epub]     CrossRef
  • Non-Laboratory-Based Simple Screening Model for Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Developed Using Multi-Center Cohorts
    Jiwon Kim, Minyoung Lee, Soo Yeon Kim, Ji-Hye Kim, Ji Sun Nam, Sung Wan Chun, Se Eun Park, Kwang Joon Kim, Yong-ho Lee, Joo Young Nam, Eun Seok Kang
    Endocrinology and Metabolism.2021; 36(4): 823.     CrossRef
  • The association of hepatic steatosis and fibrosis with heart failure and mortality
    Jiyun Park, Gyuri Kim, Hasung Kim, Jungkuk Lee, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
    Cardiovascular Diabetology.2021;[Epub]     CrossRef
  • Magnetic Resonance-Based Assessments Better Capture Pathophysiologic Profiles and Progression in Nonalcoholic Fatty Liver Disease
    Seung Joon Choi, Seong Min Kim, Yun Soo Kim, Oh Sang Kwon, Seung Kak Shin, Kyoung Kon Kim, Kiyoung Lee, Ie Byung Park, Cheol Soo Choi, Dong Hae Chung, Jaehun Jung, MunYoung Paek, Dae Ho Lee
    Diabetes & Metabolism Journal.2021; 45(5): 739.     CrossRef
  • Albuminuria Is Associated with Steatosis Burden in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease
    Eugene Han, Mi Kyung Kim, Byoung Kuk Jang, Hye Soon Kim
    Diabetes & Metabolism Journal.2021; 45(5): 698.     CrossRef
  • The potential pathophysiological role of altered lipid metabolism and electronegative low-density lipoprotein (LDL) in non-alcoholic fatty liver disease and cardiovascular diseases
    Hüseyin Vural, Ferah Armutcu, Omer Akyol, Ralf Weiskirchen
    Clinica Chimica Acta.2021; 523: 374.     CrossRef
  • Increased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study
    Kyuhoon Bang, Ji Eun Jun, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung, You-Cheol Hwang
    Diabetes & Metabolism Journal.2021; 45(6): 890.     CrossRef
  • Efficacy and Safety of GLP-1 Receptor Agonists in Patients With Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
    Yuan Zhu, Jiao Xu, Dong Zhang, Xingyu Mu, Yi Shi, Shangtao Chen, Zengxiang Wu, Shuangqing Li
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Triglyceride Glucose-Waist Circumference Is Superior to the Homeostasis Model Assessment of Insulin Resistance in Identifying Nonalcoholic Fatty Liver Disease in Healthy Subjects
    Hwi Seung Kim, Yun Kyung Cho, Eun Hee Kim, Min Jung Lee, Chang Hee Jung, Joong-Yeol Park, Hong-Kyu Kim, Woo Je Lee
    Journal of Clinical Medicine.2021; 11(1): 41.     CrossRef
  • The association between nonalcoholic fatty liver disease and esophageal, stomach, or colorectal cancer: National population-based cohort study
    Jung-Min Lee, Yong-Moon Park, Jae-Seung Yun, Yu-Bae Ahn, Kang-Moon Lee, Dae Bum Kim, Ji Min Lee, Kyungdo Han, Seung-Hyun Ko, Ming-Lung Yu
    PLOS ONE.2020; 15(1): e0226351.     CrossRef
  • Non-alcoholic steatohepatitis and progression of carotid atherosclerosis in patients with type 2 diabetes: a Korean cohort study
    Hyeok-Hee Lee, Yongin Cho, Young Ju Choi, Byung Wook Huh, Byung-Wan Lee, Eun Seok Kang, Seok Won Park, Bong-Soo Cha, Eun Jig Lee, Yong-ho Lee, Kap Bum Huh
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Visceral-to-Subcutaneous Abdominal Fat Ratio Is Associated with Nonalcoholic Fatty Liver Disease and Liver Fibrosis
    Chan-Hee Jung, Eun-Jung Rhee, Hyemi Kwon, Yoosoo Chang, Seungho Ryu, Won-Young Lee
    Endocrinology and Metabolism.2020; 35(1): 165.     CrossRef
  • Fatty liver index and development of cardiovascular disease in Koreans without pre-existing myocardial infarction and ischemic stroke: a large population-based study
    Jun Hyung Kim, Jin Sil Moon, Seok Joon Byun, Jun Hyeok Lee, Dae Ryong Kang, Ki Chul Sung, Jang Young Kim, Ji Hye Huh
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Non-invasive diagnosis of nonalcoholic fatty liver disease: impact of age and other risk factors
    Muharrem Bayrak
    The Aging Male.2020; 23(5): 1275.     CrossRef
  • Establishment of a Risk Prediction Model for Non-alcoholic Fatty Liver Disease in Type 2 Diabetes
    Yali Zhang, Rong Shi, Liang Yu, Liping Ji, Min Li, Fan Hu
    Diabetes Therapy.2020; 11(9): 2057.     CrossRef
  • Noninvasive Evaluation of Nonalcoholic Fatty Liver Disease
    Dae Ho Lee
    Endocrinology and Metabolism.2020; 35(2): 243.     CrossRef
  • Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association
    Byung-Wan Lee, Yong-ho Lee, Cheol-Young Park, Eun-Jung Rhee, Won-Young Lee, Nan-Hee Kim, Kyung Mook Choi, Keun-Gyu Park, Yeon-Kyung Choi, Bong-Soo Cha, Dae Ho Lee
    Diabetes & Metabolism Journal.2020; 44(3): 382.     CrossRef
  • Sarcopenia is associated with non-alcoholic fatty liver disease in men with type 2 diabetes
    D.H. Seo, Y.-h. Lee, S.W. Park, Y.J. Choi, B.W. Huh, E. Lee, K.B. Huh, S.H. Kim, B.-S. Cha
    Diabetes & Metabolism.2020; 46(5): 362.     CrossRef
  • Pharmacological Strategies for Insulin Sensitivity in Obesity and Cancer: Thiazolidinediones and Metformin
    Luana A. Biondo, Alexandre A. S. Teixeira, Karen C. de O. S. Ferreira, Jose C. R. Neto
    Current Pharmaceutical Design.2020; 26(9): 932.     CrossRef
  • Diabetes and Metabolism Journal in 2020: Good to Great
    In-Kyung Jeong
    Diabetes & Metabolism Journal.2020; 44(1): 1.     CrossRef
  • Toll-like receptor 9, a possible blocker of non-alcoholic steatohepatitis?
    Soung Won Jeong
    Clinical and Molecular Hepatology.2020; 26(2): 185.     CrossRef
  • The sex-specific effects of blood lead, mercury, and cadmium levels on hepatic steatosis and fibrosis: Korean nationwide cross-sectional study
    Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
    Journal of Trace Elements in Medicine and Biology.2020; 62: 126601.     CrossRef
  • Hepatic fibrosis is associated with total proteinuria in Korean patients with type 2 diabetes
    Eugene Han, Yongin Cho, Kyung-won Kim, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-wan Lee
    Medicine.2020; 99(33): e21038.     CrossRef
  • Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping
    Zhipeng Liu, Yang Zhang, Sarah Graham, Xiaokun Wang, Defeng Cai, Menghao Huang, Roger Pique-Regi, Xiaocheng Charlie Dong, Y. Eugene Chen, Cristen Willer, Wanqing Liu
    Journal of Hepatology.2020; 73(2): 263.     CrossRef
  • Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) in Patients With Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
    Marieke de Vries, Jan Westerink, Karin H A H Kaasjager, Harold W de Valk
    The Journal of Clinical Endocrinology & Metabolism.2020; 105(12): 3842.     CrossRef
  • Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease
    Kyung-Soo Kim, Byung-Wan Lee
    Clinical and Molecular Hepatology.2020; 26(4): 430.     CrossRef
  • Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective
    Eun-Jung Rhee
    Endocrinology and Metabolism.2019; 34(3): 226.     CrossRef
  • Role of sodium-glucose co-transporter-2 inhibitors in the management of nonalcoholic fatty liver disease
    Anastasia Kontana, Konstantinos Tziomalos
    World Journal of Gastroenterology.2019; 25(28): 3664.     CrossRef
Editorial
Epidemiology
Concern about the Safety of Bisphenol A Substitutes
Min Kyong Moon
Diabetes Metab J. 2019;43(1):46-48.   Published online February 19, 2019
DOI: https://doi.org/10.4093/dmj.2019.0027
  • 5,760 View
  • 76 Download
  • 61 Web of Science
  • 60 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • Toxic Ingredients in Personal Care Products: A Dermatological Perspective
    Rachel R. Lin, Deborah A. Lin, Andrea D. Maderal
    Dermatitis®.2024; 35(2): 121.     CrossRef
  • Plastic compounds and liver diseases: Whether bisphenol A is the only culprit
    Sonal Sangwan, Rajasri Bhattacharyya, Dibyajyoti Banerjee
    Liver International.2024;[Epub]     CrossRef
  • Deciphering the mechanisms and interactions of the endocrine disruptor bisphenol A and its analogs with the androgen receptor
    Rajesh Kumar Pathak, Da-Woon Jung, Seung-Hee Shin, Buom-Yong Ryu, Hee-Seok Lee, Jun-Mo Kim
    Journal of Hazardous Materials.2024; 469: 133935.     CrossRef
  • Epoxidized technical Kraft lignin as a particulate resin component for high-performance anticorrosive coatings
    Alessio Truncali, Tejasvi Laxminarayan, Narayanan Rajagopalan, Claus Erik Weinell, Søren Kiil, Mats Johansson
    Journal of Coatings Technology and Research.2024;[Epub]     CrossRef
  • Bisphenol A analysis and quantification inconsistencies via HPLC-UV: a systematic review with technical notes
    Cristian-Emilian Pop, Bogdan Andrei Miu, Dávid Németh, Robert Wolff, Dan Florin Mihăilescu, Sorin Marius Avramescu, Maria Mernea
    Discover Applied Sciences.2024;[Epub]     CrossRef
  • Gene Target Prediction of Environmental Chemicals Using Coupled Matrix–Matrix Completion
    Kai Wang, Nicole Kim, Maryam Bagherian, Kai Li, Elysia Chou, Justin A. Colacino, Dana C. Dolinoy, Maureen A. Sartor
    Environmental Science & Technology.2024; 58(13): 5889.     CrossRef
  • Exposure to Bisphenol A, S, and F and its Association with Obesity and Diabetes Mellitus in General Adults of Korea: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Min Kyong Moon, Min Joo Kim, Inae Lee, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Young Joo Park, Kyungho Choi
    Exposure and Health.2023; 15(1): 53.     CrossRef
  • An overview of the occurrence, fate, and human risks of the bisphenol‐A present in plastic materials, components, and products
    John N. Hahladakis, Eleni Iacovidou, Spyridoula Gerassimidou
    Integrated Environmental Assessment and Management.2023; 19(1): 45.     CrossRef
  • Bisphenol A alternatives continuously contribute to the endocrine disruption in cetaceans
    Yongwei Guo, Wei Shi, Zhiwei Liu, Xian Sun, Jiaxue Wu, Yuping Wu
    Environment International.2023; 171: 107679.     CrossRef
  • Interactions of Bisphenol A with Artemia franciscana and the ameliorative effect of probiotics
    Despoina Giamaki, Malamati Tsiotsiou, Sevnta Chousein Oglou, Maria Touraki
    Environmental Toxicology and Pharmacology.2023; 98: 104064.     CrossRef
  • Sex-specific associations between urinary bisphenols concentrations during pregnancy and problematic child behaviors at age 2 years
    Sarah Dee Geiger, Salma Musaad, Jennifer Hill, Andréa Aguiar, Susan Schantz
    Neurotoxicology and Teratology.2023; 96: 107152.     CrossRef
  • The Caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol A and bisphenol S
    Soňa Kucharíková, Patrícia Hockicková, Kamila Melnikov, Zuzana Bárdyová, Alžbeta Kaiglová
    Toxicology Reports.2023; 10: 341.     CrossRef
  • Endocrine-active and endocrine-disrupting compounds in food – occurrence, formation and relevance
    Constanze Stiefel, Florian Stintzing
    NFS Journal.2023; 31: 57.     CrossRef
  • Early Environment and Telomeres: a Long-Term Toxic Relationship
    José Francisco Herrera-Moreno, Diddier Prada, Andrea A. Baccarelli
    Current Environmental Health Reports.2023; 10(2): 112.     CrossRef
  • Bisphenol A prevents MCF‐7 breast cell apoptosis via the inhibition of progesterone receptor transactivation
    Masahiro Ogawa, Junya Kitamoto, Takeo Takeda, Megumi Terada
    Journal of Biochemical and Molecular Toxicology.2023;[Epub]     CrossRef
  • Interaction of micro(nano)plastics and bisphenols in the environment: A recent perspective on adsorption mechanisms, influencing factors and ecotoxic impacts
    Dandan Gao, Muhammad Junaid, Xikun Chen, Hongping Liao, Guanglong Chen, Jun Wang
    TrAC Trends in Analytical Chemistry.2023; 165: 117132.     CrossRef
  • Plastic ingestion by two cetacean groups: Ziphiidae and Delphinidae
    Sergio López-Martínez, Esther Giménez-Luque, Jose Luis Molina-Pardo, Sandra Manzano-Medina, Héctor Arribas-Arias, Rafael Gavara, Carmen Morales-Caselles, Marga L. Rivas
    Environmental Pollution.2023; 333: 121932.     CrossRef
  • Endocrine‐disrupting compounds and metabolomic reprogramming in breast cancer
    Cassandra Winz, Wei‐Xing Zong, Nanjoo Suh
    Journal of Biochemical and Molecular Toxicology.2023;[Epub]     CrossRef
  • Microwave‐assisted fractionation and functionalization of technical lignin toward thermoset resins
    Alessio Truncali, Iuliana Ribca, Jenevieve Yao, Minna Hakkarainen, Mats Johansson
    Journal of Applied Polymer Science.2023;[Epub]     CrossRef
  • Omega-3 fatty acid ameliorates bisphenol F-induced testicular toxicity by modulating Nrf2/NFkB pathway and apoptotic signaling
    Adeyemi Fatai Odetayo, Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Gestational exposure to bisphenol S induces microvesicular steatosis in male rat offspring by modulating metaflammation
    Archana Molangiri, Saikanth Varma, Kota Sri Naga Hridayanka, Myadara Srinivas, Suryam Reddy Kona, Ahamed Ibrahim, Asim K. Duttaroy, Sanjay Basak
    Science of The Total Environment.2023; 904: 166775.     CrossRef
  • The use of alternatives assessment in chemicals management policies: Needs for greater impact
    Catherine Rudisill, Molly Jacobs, Monika Roy, Lauren Brown, Rae Eaton, Tim Malloy, Holly Davies, Joel Tickner
    Integrated Environmental Assessment and Management.2023;[Epub]     CrossRef
  • The plastic health map: A systematic evidence map of human health studies on plastic-associated chemicals
    Bhedita J Seewoo, Louise M Goodes, Louise Mofflin, Yannick R Mulders, Enoch VS Wong, Priyanka Toshniwal, Manuel Brunner, Jennifer Alex, Brady Johnston, Ahmed Elagali, Aleksandra Gozt, Greg Lyle, Omrik Choudhury, Terena Solomons, Christos Symeonides, Sarah
    Environment International.2023; 181: 108225.     CrossRef
  • In Vitro Effects of Bisphenol Analogs on Immune Cells Activation and Th Differentiation
    Pia Štrukelj Pahović, Martina Iulini, Ambra Maddalon, Valentina Galbiati, Erica Buoso, Marija Sollner Dolenc, Emanuela Corsini
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2023; 23(14): 1750.     CrossRef
  • Mixture Effects of Bisphenol A and Its Structural Analogs on Estrogen Receptor Transcriptional Activation
    Handule Lee, Juyoung Park, Kwangsik Park
    Toxics.2023; 11(12): 986.     CrossRef
  • Estrogenic hazards of short chain phthalates and bisphenols found in cosmetic products
    Manel Chebbi, Asma Beltifa, Sana Alibi, Giuseppa Di Bella, Vincenzo Loturco, Olivier Sire, Hedi Ben Mansour, Véronique Le Tilly
    International Journal of Environmental Health Research.2022; 32(2): 252.     CrossRef
  • Determination of contamination levels for multiple endocrine disruptors in hair from a non-occupationally exposed population living in Liege (Belgium)
    Julien Claessens, Catherine Pirard, Corinne Charlier
    Science of The Total Environment.2022; 815: 152734.     CrossRef
  • Effects of BPA, BPS, and BPF on Oxidative Stress and Antioxidant Enzyme Expression in Bovine Oocytes and Spermatozoa
    Mimi Nguyen, Reem Sabry, Ola S. Davis, Laura A. Favetta
    Genes.2022; 13(1): 142.     CrossRef
  • Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study
    Ruth Naomi, Muhammad Dain Yazid, Hasnah Bahari, Yong Yoke Keong, Retnagowri Rajandram, Hashim Embong, Soo Huat Teoh, Shariff Halim, Fezah Othman
    International Journal of Molecular Sciences.2022; 23(6): 2969.     CrossRef
  • The Importance of Addressing Early-Life Environmental Exposures in Cancer Epidemiology
    Nicole M. Niehoff, Mandy Goldberg, Alexandra J. White
    Current Epidemiology Reports.2022; 9(2): 49.     CrossRef
  • Bisphenol B disrupts testis differentiation partly via the estrogen receptor-mediated pathway and subsequently causes testicular dysgenesis in Xenopus laevis
    Hong-Mei Li, Yuan-Yuan Li, Ying-Chi Zhang, Jin-Bo Li, Hai-Ming Xu, Yi-Ming Xiong, Zhan-Fen Qin
    Ecotoxicology and Environmental Safety.2022; 236: 113453.     CrossRef
  • Pharmacokinetics and toxicity evaluation following oral exposure to bisphenol F
    Somin Lee, Kyu Sup An, Hye Jin Kim, Hye Jin Noh, JaeWon Lee, Jiho Lee, Kyung Seuk Song, Chanhee Chae, Hyeon Yeol Ryu
    Archives of Toxicology.2022; 96(6): 1711.     CrossRef
  • Detection of Bisphenol A and Four Analogues in Atmospheric Emissions in Petrochemical Complexes Producing Polypropylene in South America
    Joaquín Hernández Fernández, Yoleima Guerra, Heidi Cano
    Molecules.2022; 27(15): 4832.     CrossRef
  • Uncovering the functions of plasma proteins in ulcerative colitis and identifying biomarkers for BPA-induced severe ulcerative colitis: A plasma proteome analysis
    Chen Huang, Yuqin Wang, Xiao Lin, Ting Fung Chan, Keng Po Lai, Rong Li
    Ecotoxicology and Environmental Safety.2022; 242: 113897.     CrossRef
  • Plastic bottle feeding produces changes in biochemical parameters in human infants – A pilot study
    Mahendra K. Pant, Abul. H. Ahmad, Manisha Naithani, Jayanti Pant
    Clinical and Experimental Pediatrics.2022; 65(9): 459.     CrossRef
  • Synthesis and reproductive toxicity of bisphenol A analogs with cyclic side chains in Caenorhabditis elegans
    Andrew H Roberts, John E Bowen, Xinrui Zhou, Isabella Burke, Maxwell H Wenaas, Timothy A Blake, Shannon C Timmons, Aleksandra Kuzmanov
    Toxicology and Industrial Health.2022; 38(10): 665.     CrossRef
  • Multi-omics approaches for remediation of bisphenol A: Toxicity, risk analysis, road blocks and research perspectives
    Poonam Sharma, Reena Vishwakarma, Sunita Varjani, Krishna Gautam, Vivek K. Gaur, Alvina Farooqui, Raveendran Sindhu, Parameswaran Binod, Mukesh Kumar Awasthi, Preeti Chaturvedi, Ashok Pandey
    Environmental Research.2022; 215: 114198.     CrossRef
  • Climate change and the water quality threats posed by the emerging contaminants per- and polyfluoroalkyl substances (PFAS) and microplastics
    Malcolm J. Gander
    Water International.2022; : 1.     CrossRef
  • Bisphenol AF induces multiple behavioral and biochemical changes in zebrafish (Danio rerio) at different life stages
    Chenyang Rao, Xianglin Cao, Lulu Li, Jiameng Zhou, Dandan Sun, Baohua Li, Suqi Guo, Rongjie Yuan, Han Cui, Jianjun Chen
    Aquatic Toxicology.2022; 253: 106345.     CrossRef
  • Endocrine disruptor chemicals as obesogen and diabetogen: Clinical and mechanistic evidence
    Niyazi Emre Kurşunoğlu, Banu Pinar Sarer Yurekli
    World Journal of Clinical Cases.2022; 10(31): 11226.     CrossRef
  • Bisphenols A and F, but not S, induce apoptosis in bovine granulosa cells via the intrinsic mitochondrial pathway
    Emilia Kourmaeva, Reem Sabry, Laura A. Favetta
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Interplay Between Endocrine Disruptors and Immunity: Implications for Diseases of Autoreactive Etiology
    Maria Popescu, Talia B. Feldman, Tanuja Chitnis
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Determination of Bisphenol Analogues in Infant Formula Products from India and Evaluating the Health Risk in Infants Asssociated with Their Exposure
    Kajal Karsauliya, Manisha Bhateria, Ashish Sonker, Sheelendra Pratap Singh
    Journal of Agricultural and Food Chemistry.2021; 69(13): 3932.     CrossRef
  • Bisphenols' occurrence in bivalves as sentinel of environmental contamination
    Elena Baralla, Valeria Pasciu, Maria Vittoria Varoni, Maria Nieddu, Roberto Demuro, Maria Piera Demontis
    Science of The Total Environment.2021; 785: 147263.     CrossRef
  • Bisphenol A and its effects on the systemic organs of children
    Sarah Zulkifli, Amirah Abdul Rahman, Siti Hamimah Sheikh Abdul Kadir, Noor Shafina Mohd Nor
    European Journal of Pediatrics.2021; 180(10): 3111.     CrossRef
  • Bisphenols disrupt thyroid hormone (TH) signaling in the brain and affect TH-dependent brain development in Xenopus laevis
    Yue Niu, Min Zhu, Mengqi Dong, Jinbo Li, Yuanyuan Li, Yiming Xiong, Pengyan Liu, Zhanfen Qin
    Aquatic Toxicology.2021; 237: 105902.     CrossRef
  • Urinary Bisphenol A Concentrations and Parameters of Ovarian Reserve among Women from a Fertility Clinic
    Ewelina Czubacka, Bartosz Wielgomas, Anna Klimowska, Michał Radwan, Paweł Radwan, Anetta Karwacka, Paweł Kałużny, Joanna Jurewicz
    International Journal of Environmental Research and Public Health.2021; 18(15): 8041.     CrossRef
  • Bisphenol S and Bisphenol F Are Less Disruptive to Cardiac Electrophysiology, as Compared With Bisphenol A
    Tomas M Prudencio, Luther M Swift, Devon Guerrelli, Blake Cooper, Marissa Reilly, Nina Ciccarelli, Jiansong Sheng, Rafael Jaimes, Nikki Gillum Posnack
    Toxicological Sciences.2021; 183(1): 214.     CrossRef
  • Effects of Bisphenol A and Its Alternatives, Bisphenol F and Tetramethyl Bisphenol F on Osteoclast Differentiation
    Hye-Min Kim, Seon-Min Lee, Jungil Choi, Nak-Kyun Soung, Jeong-Doo Heo
    Molecules.2021; 26(20): 6100.     CrossRef
  • Plastic pollution: why is it a public health problem?
    Andrew Daltry, Lea Merone, Peter Tait
    Australian and New Zealand Journal of Public Health.2021; 45(6): 535.     CrossRef
  • Evaluation of the effects of low concentrations of bisphenol AF on gonadal development using the Xenopus laevis model: A finding of testicular differentiation inhibition coupled with feminization
    Man Cai, Yuan-Yuan Li, Min Zhu, Jin-Bo Li, Zhan-Fen Qin
    Environmental Pollution.2020; 260: 113980.     CrossRef
  • Road impact in a protected area with rich biodiversity: the case of the Sebitoli road in Kibale National Park, Uganda
    Sabrina Krief, Alba Iglesias-González, Brice Marc René Appenzeller, John Paul Okimat, Jean-Baptiste Fini, Barbara Demeneix, Sophie Vaslin-Reimann, Sophie Lardy-Fontan, Nelson Guma, Petra Spirhanzlova
    Environmental Science and Pollution Research.2020; 27(22): 27914.     CrossRef
  • Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes
    Manelle Ramadan, Blake Cooper, Nikki Gillum Posnack
    Birth Defects Research.2020; 112(17): 1362.     CrossRef
  • Insights into the interactions of bisphenol and phthalate compounds with unamended and carnitine-amended montmorillonite clays
    Asuka A. Orr, Shujun He, Meichen Wang, Alicia Goodall, Sara E. Hearon, Timothy D. Phillips, Phanourios Tamamis
    Computers & Chemical Engineering.2020; 143: 107063.     CrossRef
  • Challenges of plastic waste generation and management in sub-Saharan Africa: A review
    Olusola Olaitan Ayeleru, Sisanda Dlova, Ojo Jeremiah Akinribide, Freeman Ntuli, Williams Kehinde Kupolati, Paula Facal Marina, Anton Blencowe, Peter Apata Olubambi
    Waste Management.2020; 110: 24.     CrossRef
  • Changes in lipid profiles induced by bisphenol A (BPA) in zebrafish eleutheroembryos during the yolk sac absorption stage
    Rubén Martínez, Laia Navarro-Martín, Morgane van Antro, Inmaculada Fuertes, Marta Casado, Carlos Barata, Benjamin Piña
    Chemosphere.2020; 246: 125704.     CrossRef
  • Plastics derived endocrine‐disrupting compounds and their effects on early development
    Sanjay Basak, Mrinal K. Das, Asim K. Duttaroy
    Birth Defects Research.2020; 112(17): 1308.     CrossRef
  • Estimated Dietary Bisphenol-A Exposure and Adiposity in Samoan Mothers and Children
    Lacey W. Heinsberg, Christina N.N. Bui, Jennifer C. Hartle, Susan M. Sereika, Courtney C. Choy, Dongqing Wang, Christina Soti-Ulberg, Take Naseri, Muagututia Sefuiva Reupena, Rachel L. Duckham, Jennifer J. Park, Nicola L. Hawley, Nicole C. Deziel
    Toxics.2020; 8(3): 67.     CrossRef
  • Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease
    Ilaria Cimmino, Francesca Fiory, Giuseppe Perruolo, Claudia Miele, Francesco Beguinot, Pietro Formisano, Francesco Oriente
    International Journal of Molecular Sciences.2020; 21(16): 5761.     CrossRef
  • Toxicological considerations of nano-sized plastics
    PA Stapleton
    AIMS Environmental Science.2019; 6(5): 367.     CrossRef
Original Articles
Clinical Diabetes and Therapeutics
Hospital-Based Korean Diabetes Prevention Study: A Prospective, Multi-Center, Randomized, Open-Label Controlled Study
Sang Youl Rhee, Suk Chon, Kyu Jeung Ahn, Jeong-Taek Woo
Diabetes Metab J. 2019;43(1):49-58.   Published online November 2, 2018
DOI: https://doi.org/10.4093/dmj.2018.0033
  • 5,236 View
  • 130 Download
  • 10 Web of Science
  • 13 Crossref
AbstractAbstract PDFPubReader   
Background

The prevalence of diabetes mellitus (DM) continues to increase, and the disease burden is the highest of any medical condition in Korea. However, large-scale clinical studies have not yet conducted to establish the basis for diabetes prevention in Korea.

Methods

The hospital-based Korean Diabetes Prevention Study (H-KDPS) is a prospective, multi-center, randomized, open-label controlled study conducted at university hospitals for the purpose of gathering data to help in efforts to prevent type 2 DM. Ten university hospitals are participating, and 744 subjects will be recruited. The subjects are randomly assigned to the standard care group, lifestyle modification group, or metformin group, and their clinical course will be observed for 36 months.

Results

All intervention methodologies were developed, validated, and approved by Korean Diabetes Association (KDA) multi-disciplinary team members. The standard control group will engage in individual education based on the current KDA guidelines, and the lifestyle modification group will participate in a professionally guided healthcare intervention aiming for ≥5% weight loss. The metformin group will begin dosing at 250 mg/day, increasing to a maximum of 1,000 mg/day. The primary endpoint of this study is the cumulative incidence of DM during the 3 years after randomization.

Conclusion

The H-KDPS study is the first large-scale clinical study to establish evidence-based interventions for the prevention of type 2 DM in Koreans. The evidence gathered by this study will be useful for enhancing the health of Koreans and improving the stability of the Korean healthcare system (Trial registration: CRIS KCT0002260, NCT02981121).

Citations

Citations to this article as recorded by  
  • Estimating insulin sensitivity and β-cell function from the oral glucose tolerance test: validation of a new insulin sensitivity and secretion (ISS) model
    Joon Ha, Stephanie T. Chung, Max Springer, Joon Young Kim, Phil Chen, Aaryan Chhabra, Melanie G. Cree, Cecilia Diniz Behn, Anne E. Sumner, Silva A. Arslanian, Arthur S. Sherman
    American Journal of Physiology-Endocrinology and Metabolism.2024; 326(4): E454.     CrossRef
  • Development and Adaptability of Smartphone-based Dietary Coaching Program for Patients Undergoing Diabetes and Prediabetes with Continuous Glucose Monitoring Device
    Myoung Soo Kim, Jung Mi Ryu, Minkyeong Kang, Jiwon Park, Yeh Chan Ahn, Yang Seok Kim
    Journal of Health Informatics and Statistics.2023; 48(1): 36.     CrossRef
  • Improving Machine Learning Diabetes Prediction Models for the Utmost Clinical Effectiveness
    Juyoung Shin, Joonyub Lee, Taehoon Ko, Kanghyuck Lee, Yera Choi, Hun-Sung Kim
    Journal of Personalized Medicine.2022; 12(11): 1899.     CrossRef
  • Impaired fasting glucose levels in overweight or obese subjects for screening of type 2 diabetes in Korea
    Jin-Hee Lee, Suk Chon, Seon-Ah Cha, Sun-Young Lim, Kook-Rye Kim, Jae-Seung Yun, Sang Youl Rhee, Kun-Ho Yoon, Yu-Bae Ahn, Jeong-Taek Woo, Seung-Hyun Ko
    The Korean Journal of Internal Medicine.2021; 36(2): 382.     CrossRef
  • Development and Validation of a Deep Learning Based Diabetes Prediction System Using a Nationwide Population-Based Cohort
    Sang Youl Rhee, Ji Min Sung, Sunhee Kim, In-Jeong Cho, Sang-Eun Lee, Hyuk-Jae Chang
    Diabetes & Metabolism Journal.2021; 45(4): 515.     CrossRef
  • 2021 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
    Kyu Yeon Hur, Min Kyong Moon, Jong Suk Park, Soo-Kyung Kim, Seung-Hwan Lee, Jae-Seung Yun, Jong Ha Baek, Junghyun Noh, Byung-Wan Lee, Tae Jung Oh, Suk Chon, Ye Seul Yang, Jang Won Son, Jong Han Choi, Kee Ho Song, Nam Hoon Kim, Sang Yong Kim, Jin Wha Kim,
    Diabetes & Metabolism Journal.2021; 45(4): 461.     CrossRef
  • Short-Term Effects of the Internet-Based Korea Diabetes Prevention Study: 6-Month Results of a Community-Based Randomized Controlled Trial
    Jin-Hee Lee, Sun-Young Lim, Seon-Ah Cha, Chan-Jung Han, Ah Reum Jung, Kook-Rye Kim, Kun-Ho Yoon, Seung-Hyun Ko
    Diabetes & Metabolism Journal.2021; 45(6): 960.     CrossRef
  • 2021 Clinical Practice Guidelines for Diabetes Mellitus in Korea
    Seung-Hyun Ko
    The Journal of Korean Diabetes.2021; 22(4): 244.     CrossRef
  • Optimal fasting plasma glucose and haemoglobin A1c levels for screening of prediabetes and diabetes according to 2‐hour plasma glucose in a high‐risk population: The Korean Diabetes Prevention Study
    Seon‐Ah Cha, Suk Chon, Jae‐Seung Yun, Sang Youl Rhee, Sun‐Young Lim, Kun‐Ho Yoon, Yu‐Bae Ahn, Seung‐Hyun Ko, Jeong‐Taek Woo, Jin‐Hee Lee
    Diabetes/Metabolism Research and Reviews.2020;[Epub]     CrossRef
  • How was the Diabetes Metabolism Journal added to MEDLINE?
    Hye Jin Yoo
    Science Editing.2020; 7(2): 201.     CrossRef
  • Commercial Postural Devices: A Review
    Nicole Kah Mun Yoong, Jordan Perring, Ralph Jasper Mobbs
    Sensors.2019; 19(23): 5128.     CrossRef
  • Changes in Metabolic Profile Over Time: Impact on the Risk of Diabetes
    Yunjung Cho, Seung-Hwan Lee
    Diabetes & Metabolism Journal.2019; 43(4): 407.     CrossRef
  • Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus
    Kasper S Madsen, Yuan Chi, Maria-Inti Metzendorf, Bernd Richter, Bianca Hemmingsen
    Cochrane Database of Systematic Reviews.2019;[Epub]     CrossRef
Epidemiology
Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents
Buyun Liu, Hans-Joachim Lehmler, Yangbo Sun, Guifeng Xu, Qi Sun, Linda G. Snetselaar, Robert B. Wallace, Wei Bao
Diabetes Metab J. 2019;43(1):59-75.   Published online February 19, 2019
DOI: https://doi.org/10.4093/dmj.2018.0045
  • 5,817 View
  • 154 Download
  • 91 Web of Science
  • 91 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used as substitutes for bisphenol A (BPA), an environmental obesogen. However, health effects of BPF and BPS remain unclear. In this study, we evaluated the associations of BPA, BPF, and BPS with obesity in children and adolescents.

Methods

We used data from the U.S. National Health and Nutrition Examination Survey 2013 to 2014, a nationally representative study. We included 745 participants aged 6 to 17 years old. General obesity was defined based on the 2000 Centers for Disease Control and Prevention body mass index-for-age growth charts for the United States. Abdominal obesity was defined as waist-to-height ratio ≥0.5.

Results

After adjustment for demographic, socioeconomic and lifestyle factors, and urinary creatinine levels, the odds ratio of general obesity comparing the highest with lowest quartile of urinary bisphenol levels was 1.74 (95% confidence interval [CI], 0.92 to 3.31) for BPA, 1.54 (95% CI, 1.02 to 2.32) for BPF, and 1.36 (95% CI, 0.53 to 3.51) for BPS. Moreover, the associations were stronger in boys than in girls for BPA and BPF. Similar results were observed for abdominal obesity.

Conclusion

This study for the first time showed that exposure to BPF, a commonly used substitute for BPA, was positively associated with higher risk of obesity in children and adolescents. The association of BPA and BPF with general and abdominal obesity was primarily observed in boys, suggesting a possible sex difference. Further investigations on the underlying mechanisms are needed.

Citations

Citations to this article as recorded by  
  • Bisphenol S, bisphenol F, bisphenol a exposure and body composition in US adults
    Buyun Liu, Yuxiang Yan, Juan Xie, Jian Sun, Hans-Joachim Lehmler, Leonardo Trasande, Robert B. Wallace, Wei Bao
    Chemosphere.2024; 346: 140537.     CrossRef
  • Sex and Gender Differences on the Impact of Metabolism-Disrupting Chemicals on Obesity: A Systematic Review
    Massimo D’Archivio, Lucia Coppola, Roberta Masella, Alessia Tammaro, Cinzia La Rocca
    Nutrients.2024; 16(2): 181.     CrossRef
  • The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies
    Maria Dalamaga, Dimitrios Kounatidis, Dimitrios Tsilingiris, Natalia G. Vallianou, Irene Karampela, Sotiria Psallida, Athanasios G. Papavassiliou
    International Journal of Molecular Sciences.2024; 25(1): 675.     CrossRef
  • Sex-specific associations of bisphenol A and its substitutes with body fat distribution among US adults: NHANES 2011–2016
    Shili Zhang, Lingyan Dai, Ziyu Wan, Zhiwei Huang, Mengchen Zou, Haixia Guan
    Environmental Science and Pollution Research.2024; 31(5): 7948.     CrossRef
  • EDC mixtures during pregnancy and body fat at 7 years of age in a Swedish cohort, the SELMA study
    Katherine Svensson, Chris Gennings, Christian Lindh, Hannu Kiviranta, Panu Rantakokko, Sverre Wikström, Carl-Gustaf Bornehag
    Environmental Research.2024; 248: 118293.     CrossRef
  • Chemical Composition of Leachates from Hydraulic Fracturing Proppants from Surficial Releases in Southeastern New Mexico
    Matthew S. Varonka, Terry G. Gregston, Michael Villalobos, Jacqueline P. Green, William H. Orem
    Environmental Science & Technology Letters.2024; 11(3): 243.     CrossRef
  • Associations of bisphenol A exposure with metabolic syndrome and its components: A systematic review and meta‐analysis
    Tianli Xiao, Zehua Huang, Chanjuan Zheng, Binh Quach, Yulian Zhu, Feifei Li, Wei Liang, Julien Baker, Christoph Reichetzeder, Berthold Hocher, Yide Yang
    Obesity Reviews.2024;[Epub]     CrossRef
  • Relationship of bisphenol A substitutes bisphenol F and bisphenol S with adiponectin/leptin ratio among children from the environment and development of children cohort
    Hye Jin Lee, Yun Jeong Lee, Youn-Hee Lim, Hwa Young Kim, Bung-Nyun Kim, Johanna Inhyang Kim, Yong Min Cho, Yun-Chul Hong, Choong Ho Shin, Young Ah Lee
    Environment International.2024; 185: 108564.     CrossRef
  • Obesogenic effects of six classes of emerging contaminants
    Siying Wu, Chaoyu Tong, Jing Liu
    Journal of Environmental Sciences.2024;[Epub]     CrossRef
  • Exposure to Bisphenol A, S, and F and its Association with Obesity and Diabetes Mellitus in General Adults of Korea: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Min Kyong Moon, Min Joo Kim, Inae Lee, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Young Joo Park, Kyungho Choi
    Exposure and Health.2023; 15(1): 53.     CrossRef
  • Evaluation of toxicological effects of bisphenol S with an in vitro human bone marrow mesenchymal stem cell: Implications for bone health
    Mei Li, Tenglong Li, Juan Yin, Chunfeng Xie, Jianyun Zhu
    Toxicology.2023; 484: 153408.     CrossRef
  • In silico profiling of endocrine-disrupting potential of bisphenol analogues and their halogenated transformation products
    Karolina Nowak, Žiga Jakopin
    Food and Chemical Toxicology.2023; 173: 113623.     CrossRef
  • Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice
    Pieter Vancamp, Lucile Butruille, Anni Herranen, Anita Boelen, Jean-Baptiste Fini, Barbara A. Demeneix, Sylvie Remaud
    Environment International.2023; 172: 107770.     CrossRef
  • Development of human dermal PBPK models for the bisphenols BPA, BPS, BPF, and BPAF with parallel-layered skin compartment: Basing on dermal administration studies in humans
    Man Hu, Zhichun Zhang, Yining Zhang, Ming Zhan, Weidong Qu, Gengsheng He, Ying Zhou
    Science of The Total Environment.2023; 868: 161639.     CrossRef
  • Postnatal exposure to Bisphenol S induces liver injury in mice: Possible implication of PPARγ receptor
    Bessem Mornagui, Raja Rezg, Fadoua Neffati, Mohamed Fadhel Najjar, Ahmed Rejeb
    Toxicology and Industrial Health.2023; 39(5): 237.     CrossRef
  • JAK3/STAT5b/PPARγ Pathway Mediates the Association between Di(2-ethylhexyl) Phthalate Exposure and Lipid Metabolic Disorder in Chinese Adolescent Students
    Qi Xu, Shuang Ding, Wen Qi, Xueting Zhang, Meng Zhang, Jiqiang Xing, Aipeng Ju, Liting Zhou, Lin Ye
    Chemical Research in Toxicology.2023; 36(5): 725.     CrossRef
  • Bisphenol A substitutes and childhood obesity at 7 years: a cross-sectional study in Shandong, China
    Minyan Chen, Cheng Lv, Shanyu Zhang, Lap Ah Tse, Xinyu Hong, Xi Liu, Yu Ding, Ping Xiao, Ying Tian, Yu Gao
    Environmental Science and Pollution Research.2023; 30(29): 73174.     CrossRef
  • Association between Bisphenol A exposure and body composition parameters in children
    Yong Guo, Cui Liu, Yu-Hong Deng, Jing Ning, Li Yu, Jie-Ling Wu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Urinary neonicotinoid insecticides and adiposity measures among 7-year-old children in northern China: A cross-sectional study
    Zhenping Lu, Yi Hu, Lap Ah Tse, Jinxia Yu, Zhuanning Xia, Xiaoning Lei, Yan Zhang, Rong Shi, Ying Tian, Yu Gao
    International Journal of Hygiene and Environmental Health.2023; 251: 114188.     CrossRef
  • Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish
    Yeonhwa Kim, Seong Soon Kim, Byeong Heon Park, Kyu-Seok Hwang, Myung Ae Bae, Sung-Hee Cho, Suhyun Kim, Hae-Chul Park
    Toxics.2023; 11(6): 477.     CrossRef
  • The effects of trans fat diet intake on metabolic parameters and pancreatic tissue in offspring of prenatal bisphenol A exposed rats
    Hala Abulehia, Noor Shafina Mohd Nor, Siti Hamimah Sheikh Abdul Kadir, Mardiana Abdul Aziz, Sarah Zulkifli
    Scientific Reports.2023;[Epub]     CrossRef
  • Genetic background in the rat affects endocrine and metabolic outcomes of bisphenol F exposure
    Valerie A Wagner, Katie L Holl, Karen C Clark, John J Reho, Melinda R Dwinell, Hans-Joachim Lehmler, Hershel Raff, Justin L Grobe, Anne E Kwitek
    Toxicological Sciences.2023; 194(1): 84.     CrossRef
  • Association of parabens and bisphenols with lung function in children aged 5–12 years from Shanghai, China
    Yi Hu, Hao Chen, Yuan Tian, Dan Wu, Angela Vinturache, Guodong Ding, Guangjun Yu
    International Journal of Hygiene and Environmental Health.2023; 252: 114210.     CrossRef
  • Bisphenol A substitutes and obesity: a review of the epidemiology and pathophysiology
    Shane V. Varghese, Julianne M. Hall
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Levels of Bisphenol A and its analogs in nails, saliva, and urine of children: a case control study
    Yolanda Gálvez-Ontiveros, Inmaculada Moscoso-Ruiz, Vega Almazán Fernández de Bobadilla, Celia Monteagudo, Rafael Giménez-Martínez, Lourdes Rodrigo, Alberto Zafra-Gómez, Ana Rivas
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • Exposure to Bisphenol A and Its Analogs among Thai School-Age Children
    Nattakarn Numsriskulrat, Thanawan Teeranathada, Chansuda Bongsebandhu-Phubhakdi, Suphab Aroonparkmongkol, Kyungho Choi, Vichit Supornsilchai
    Toxics.2023; 11(9): 761.     CrossRef
  • Bisphenol analogues inhibit human and rat 17β-hydroxysteroid dehydrogenase 1: 3D-quantitative structure-activity relationship (3D-QSAR) and in silico docking analysis
    Sailing Chen, Shaowei Wang, Jingyi Zheng, Han Lu, Huiqian Chen, Yunbing Tang, Nan Wang, Yang Zhu, Yiyan Wang, Ping Duan, Ren-shan Ge
    Food and Chemical Toxicology.2023; 181: 114052.     CrossRef
  • Associations of prenatal exposure to bisphenols with BMI growth trajectories in offspring within the first two years: evidence from a birth cohort study in China
    Chao Xiong, Kai Chen, Lu-Li Xu, Yi-Ming Zhang, Hua Liu, Meng-Lan Guo, Zhi-Guo Xia, Yu-Ji Wang, Xiao-Feng Mu, Xiao-Xuan Fan, Jing-Quan Chen, Yu-Ru Liu, Yuan-Yuan Li, Wei Xia, You-Jie Wang, Ai-Fen Zhou
    World Journal of Pediatrics.2023;[Epub]     CrossRef
  • Ecotoxicological Evaluation of Bisphenol A and Alternatives: A Comprehensive In Silico Modelling Approach
    Liadys Mora Lagares, Marjan Vračko
    Journal of Xenobiotics.2023; 13(4): 719.     CrossRef
  • Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases
    Jeong-Hun Kang, Daisuke Asai, Riki Toita
    Journal of Xenobiotics.2023; 13(4): 775.     CrossRef
  • Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the available evidence in relation to the potential obesogenic activity of certain chemical compounds that may be present in foods
    Ana María Rivas Velasco, Irene Bretón Lesmes, Araceli Díaz Perales, Ángel Gil Izquierdo, María José González Muñoz, Victoria Moreno Arribas, María del Puy Portillo Baquedano, Silvia Pichardo Sánchez
    Food Risk Assess Europe.2023;[Epub]     CrossRef
  • Regulatory and academic studies to derive reference values for human health: The case of bisphenol S
    Claire Beausoleil, Brigitte Le Magueresse-Battistoni, Catherine Viguié, Sylvie Babajko, Marie-Chantal Canivenc-Lavier, Nicolas Chevalier, Claude Emond, René Habert, Nicole Picard-Hagen, Sakina Mhaouty-Kodja
    Environmental Research.2022; 204: 112233.     CrossRef
  • Urinary bisphenol concentrations and its association with metabolic disorders in the US and Korean populations
    Ji Yoon Choi, Jiyun Lee, Da-An Huh, Kyong Whan Moon
    Environmental Pollution.2022; 295: 118679.     CrossRef
  • Associations of mid-childhood bisphenol A and bisphenol S exposure with mid-childhood and adolescent obesity
    Priya Gajjar, Yun Liu, Nan Li, Jessie P. Buckley, Aimin Chen, Bruce P. Lanphear, Heidi J. Kalkwarf, Kim M. Cecil, Kimberly Yolton, Joseph M. Braun
    Environmental Epidemiology.2022; 6(1): e187.     CrossRef
  • Profile of Environmental Chemicals in the Korean Population—Results of the Korean National Environmental Health Survey (KoNEHS) Cycle 3, 2015–2017
    Sun Kyoung Jung, Wookhee Choi, Sung Yeon Kim, Sooyeon Hong, Hye Li Jeon, Youngkyung Joo, Chulwoo Lee, Kyungho Choi, Sungkyoon Kim, Kee-Jae Lee, Jiyoung Yoo
    International Journal of Environmental Research and Public Health.2022; 19(2): 626.     CrossRef
  • The bisphenol F and bisphenol S and cardiovascular disease: results from NHANES 2013–2016
    Ruihua Wang, Qiaoyuan Fei, Shan Liu, Xueqiong Weng, Huanzhu Liang, Yingying Wu, Lin Wen, Guang Hao, Guangwen Cao, Chunxia Jing
    Environmental Sciences Europe.2022;[Epub]     CrossRef
  • Bisphenols A and its analogues induce genotoxic damage in marine and freshwater amphipods
    Serena Cosentino, Federica Aureli, Valentina Iannilli
    Environmental Advances.2022; 7: 100183.     CrossRef
  • Impact of environmental pollution on the obesogenic environment
    Adriana Martínez-Esquivel, Daniela Joyce Trujillo-Silva, V Gabriela Cilia-López
    Nutrition Reviews.2022; 80(7): 1787.     CrossRef
  • Effects of BPZ and BPC on Oxidative Stress of Zebrafish under Different pH Conditions
    Ying Han, Yumeng Fei, Mingxin Wang, Yingang Xue, Yuxuan Liu
    Molecules.2022; 27(5): 1568.     CrossRef
  • Race-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across the Nation (SWAN)
    Seulbi Lee, Carrie Karvonen-Gutierrez, Bhramar Mukherjee, William H. Herman, Sung Kyun Park
    Environmental Pollution.2022; 303: 119164.     CrossRef
  • Are BPA Substitutes as Obesogenic as BPA?
    Fabiana Oliviero, Alice Marmugi, Catherine Viguié, Véronique Gayrard, Nicole Picard-Hagen, Laila Mselli-Lakhal
    International Journal of Molecular Sciences.2022; 23(8): 4238.     CrossRef
  • Aptamer-Based Biosensors for the Analytical Determination of Bisphenol A in Foodstuffs
    Marica Erminia Schiano, Avazbek Abduvakhidov, Michela Varra, Stefania Albrizio
    Applied Sciences.2022; 12(8): 3752.     CrossRef
  • Bisphenol A exposure induces multiple effects in DOPC membrane models
    Mateus D. Maximino, Cibely S. Martin, Priscila Aléssio
    Journal of Molecular Liquids.2022; 359: 119253.     CrossRef
  • Bisphenol S induces Agrp expression through GPER1 activation and alters transcription factor expression in immortalized hypothalamic neurons: A mechanism distinct from BPA-induced upregulation
    Katherine J. Xu, Neruja Loganathan, Denise D. Belsham
    Molecular and Cellular Endocrinology.2022; 552: 111630.     CrossRef
  • Bisphenol S Alters the Steroidome in the Preovulatory Follicle, Oviduct Fluid and Plasma in Ewes With Contrasted Metabolic Status
    Ophélie Téteau, Philippe Liere, Antoine Pianos, Alice Desmarchais, Olivier Lasserre, Pascal Papillier, Claire Vignault, Marie-Emilie Lebachelier de la Riviere, Virginie Maillard, Aurélien Binet, Svetlana Uzbekova, Marie Saint-Dizier, Sebastien Elis
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Relationship between bisphenol A, bisphenol S, and bisphenol F and serum uric acid concentrations among school-aged children
    Yun Jeong Lee, Youn-Hee Lim, Choong Ho Shin, Bung-Nyun Kim, Johanna Inhyang Kim, Yun-Chul Hong, Yong Min Cho, Young Ah Lee, Pasquale Avino
    PLOS ONE.2022; 17(6): e0268503.     CrossRef
  • Associations of bisphenol exposure with thyroid hormones in pregnant women: a prospective birth cohort study in China
    Huishen Huang, Jun Liang, Peng Tang, Chuanxiang Yu, Haoran Fan, Qian Liao, Jinghua Long, Dongxiang Pan, Xiaoyun Zeng, Shun Liu, Dongping Huang, Xiaoqiang Qiu
    Environmental Science and Pollution Research.2022; 29(58): 87170.     CrossRef
  • Association between urinary concentrations of bisphenol A substitutes and diabetes in adults
    Rafael Moreno-Gómez-Toledano, Esperanza Vélez-Vélez, María I Arenas, Marta Saura, Ricardo J Bosch
    World Journal of Diabetes.2022; 13(7): 521.     CrossRef
  • Uncovering the functions of plasma proteins in ulcerative colitis and identifying biomarkers for BPA-induced severe ulcerative colitis: A plasma proteome analysis
    Chen Huang, Yuqin Wang, Xiao Lin, Ting Fung Chan, Keng Po Lai, Rong Li
    Ecotoxicology and Environmental Safety.2022; 242: 113897.     CrossRef
  • Relationship between emergent BPA-substitutes and renal and cardiovascular diseases in adult population
    Rafael Moreno-Gómez-Toledano
    Environmental Pollution.2022; 313: 120106.     CrossRef
  • Climate change and the water quality threats posed by the emerging contaminants per- and polyfluoroalkyl substances (PFAS) and microplastics
    Malcolm J. Gander
    Water International.2022; : 1.     CrossRef
  • Endocrine disruptor chemicals as obesogen and diabetogen: Clinical and mechanistic evidence
    Niyazi Emre Kurşunoğlu, Banu Pinar Sarer Yurekli
    World Journal of Clinical Cases.2022; 10(31): 11226.     CrossRef
  • Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, and Its Association with Developing Obesity and Diabetes Mellitus: A Narrative Review
    Hend F. Alharbi, Raya Algonaiman, Rana Alduwayghiri, Thamer Aljutaily, Reham M. Algheshairy, Abdulkarim S. Almutairi, Razan M. Alharbi, Leena A. Alfurayh, Amjad A. Alshahwan, Amjad F. Alsadun, Hassan Barakat
    International Journal of Environmental Research and Public Health.2022; 19(23): 15918.     CrossRef
  • Influence of BPA exposure, measured in saliva, on childhood weight
    Leticia Heras-González, Diana Espino, Maria Jose Jimenez-Casquet, Alejandro Lopez-Moro, Fatima Olea-Serrano, Miguel Mariscal-Arcas
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Bisphenol S enhances gap junction intercellular communication in ovarian theca cells
    Jeremy Gingrich, Yong Pu, Brad L. Upham, Madeline Hulse, Sarah Pearl, Denny Martin, Anita Avery, Almudena Veiga-Lopez
    Chemosphere.2021; 263: 128304.     CrossRef
  • Exposure to bisphenols and asthma morbidity among low-income urban children with asthma
    Lesliam Quirós-Alcalá, Nadia N. Hansel, Meredith McCormack, Antonia M. Calafat, Xiaoyun Ye, Roger D. Peng, Elizabeth C. Matsui
    Journal of Allergy and Clinical Immunology.2021; 147(2): 577.     CrossRef
  • Evaluation of the effects of low nanomolar bisphenol A-like compounds’ levels on early human embryonic development and lipid metabolism with human embryonic stem cell in vitro differentiation models
    Xiaoxing Liang, Renjun Yang, Nuoya Yin, Francesco Faiola
    Journal of Hazardous Materials.2021; 407: 124387.     CrossRef
  • Young children’s exposure to phenols in the home: Associations between house dust, hand wipes, silicone wristbands, and urinary biomarkers
    Jessica L. Levasseur, Stephanie C. Hammel, Kate Hoffman, Allison L. Phillips, Sharon Zhang, Xiaoyun Ye, Antonia M. Calafat, Thomas F. Webster, Heather M. Stapleton
    Environment International.2021; 147: 106317.     CrossRef
  • Endocrine disrupting chemicals: Impacts on human fertility and fecundity during the peri-conception period
    Mark P. Green, Alexandra J. Harvey, Bethany J. Finger, Gerard A. Tarulli
    Environmental Research.2021; 194: 110694.     CrossRef
  • Environmental Factors Involved in Maternal Morbidity and Mortality
    Abee L. Boyles, Brandiese E. Beverly, Suzanne E. Fenton, Chandra L. Jackson, Anne Marie Z. Jukic, Vicki L. Sutherland, Donna D. Baird, Gwen W. Collman, Darlene Dixon, Kelly K. Ferguson, Janet E. Hall, Elizabeth M. Martin, Thaddeus T. Schug, Alexandra J. W
    Journal of Women's Health.2021; 30(2): 245.     CrossRef
  • Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway
    Laura Marroqui, Juan Martinez-Pinna, Manuel Castellano-Muñoz, Reinaldo S. dos Santos, Regla M. Medina-Gali, Sergi Soriano, Ivan Quesada, Jan-Ake Gustafsson, José A. Encinar, Angel Nadal
    Chemosphere.2021; 265: 129051.     CrossRef
  • Urinary bisphenol A concentrations and the risk of obesity in Korean adults
    Shinje Moon, Moon Young Seo, Kyungho Choi, Yoon-seok Chang, Shin-Hye Kim, Mi Jung Park
    Scientific Reports.2021;[Epub]     CrossRef
  • Transcriptomic pathway and benchmark dose analysis of Bisphenol A, Bisphenol S, Bisphenol F, and 3,3',5,5'-Tetrabromobisphenol A in H9 human embryonic stem cells
    Vian Peshdary, Cheryl A. Hobbs, Timothy Maynor, Kim Shepard, Remi Gagné, Andrew Williams, Byron Kuo, Nikolai Chepelev, Leslie Recio, Carole Yauk, Ella Atlas
    Toxicology in Vitro.2021; 72: 105097.     CrossRef
  • Prenatal exposure to bisphenols and cognitive function in children at 7 years of age in the Swedish SELMA study
    Carl-Gustaf Bornehag, Elin Engdahl, Maria Unenge Hallerbäck, Sverre Wikström, Christian Lindh, Joëlle Rüegg, Eva Tanner, Chris Gennings
    Environment International.2021; 150: 106433.     CrossRef
  • Urinary bisphenol A levels in prepubertal children with exogenous obesity according to presence of metabolic syndrome
    Esra Aktağ, Kadriye Yurdakök, Siddika Songül Yalçın, Nurgün Kandemir
    Journal of Pediatric Endocrinology and Metabolism.2021; 34(4): 495.     CrossRef
  • Metabolic pathways, alterations in miRNAs expression and effects of genetic polymorphisms of bisphenol a analogues: A systematic review
    Viviana Ramírez, Yolanda Gálvez-Ontiveros, Patricia Porras-Quesada, Luis Javier Martinez-Gonzalez, Ana Rivas, María Jesús Álvarez-Cubero
    Environmental Research.2021; 197: 111062.     CrossRef
  • Dietary quality and bisphenols: trends in bisphenol A, F, and S exposure in relation to the Healthy Eating Index using representative data from the NHANES 2007–2016
    Irene van Woerden, Devon C Payne-Sturges, Corrie M Whisner, Meg Bruening
    The American Journal of Clinical Nutrition.2021; 114(2): 669.     CrossRef
  • Bisphenol A and its effects on the systemic organs of children
    Sarah Zulkifli, Amirah Abdul Rahman, Siti Hamimah Sheikh Abdul Kadir, Noor Shafina Mohd Nor
    European Journal of Pediatrics.2021; 180(10): 3111.     CrossRef
  • Bisphenols' occurrence in bivalves as sentinel of environmental contamination
    Elena Baralla, Valeria Pasciu, Maria Vittoria Varoni, Maria Nieddu, Roberto Demuro, Maria Piera Demontis
    Science of The Total Environment.2021; 785: 147263.     CrossRef
  • Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity
    Valerie A Wagner, Karen C Clark, Leslie Carrillo-Sáenz, Katie A Holl, Miriam Velez-Bermudez, Derek Simonsen, Justin L Grobe, Kai Wang, Andrew Thurman, Leah C Solberg Woods, Hans-Joachim Lehmler, Anne E Kwitek
    Toxicological Sciences.2021; 181(2): 246.     CrossRef
  • Factors Associated with Exposure to Dietary Bisphenols in Adolescents
    Virginia Robles-Aguilera, Yolanda Gálvez-Ontiveros, Lourdes Rodrigo, Inmaculada Salcedo-Bellido, Margarita Aguilera, Alberto Zafra-Gómez, Celia Monteagudo, Ana Rivas
    Nutrients.2021; 13(5): 1553.     CrossRef
  • Impact of short-term change of adiposity on risk of high blood pressure in children: Results from a follow-up study in China
    Yi-de Yang, Ming Xie, Yuan Zeng, Shuqian Yuan, Haokai Tang, Yanhui Dong, Zhiyong Zou, Bin Dong, Zhenghe Wang, Xiangli Ye, Xiuqin Hong, Qiu Xiao, Jun Ma, Raffaella Buzzetti
    PLOS ONE.2021; 16(9): e0257144.     CrossRef
  • Life-Time Environmental Chemical Exposure and Obesity: Review of Epidemiological Studies Using Human Biomonitoring Methods
    Nayan Chandra Mohanto, Yuki Ito, Sayaka Kato, Michihiro Kamijima
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Italian Children Exposure to Bisphenol A: Biomonitoring Data from the LIFE PERSUADED Project
    Sabrina Tait, Fabrizia Carli, Luca Busani, Demetrio Ciociaro, Veronica Della Latta, Annalisa Deodati, Enrica Fabbrizi, Anna Paola Pala, Francesca Maranghi, Roberta Tassinari, Giacomo Toffol, Stefano Cianfarani, Amalia Gastaldelli, Cinzia La Rocca
    International Journal of Environmental Research and Public Health.2021; 18(22): 11846.     CrossRef
  • Bisphenol A disrupts apolipoprotein E expression through estrogen-related receptor gamma and DNA methlylation in the liver of male rare minnow Gobiocypris rarus
    Yingying Zhang, Zhu Zhu, Qiao Liu, Meng Zhang, Hui Yang, Wenzhi Wei
    Ecotoxicology and Environmental Safety.2021; 228: 113041.     CrossRef
  • Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects
    Elsi Haverinen, Mariana F. Fernandez, Vicente Mustieles, Hanna Tolonen
    International Journal of Environmental Research and Public Health.2021; 18(24): 13047.     CrossRef
  • Obesogens in Children—An Uncharted Territory
    Mirjam Močnik, Nataša Marčun Varda
    Metabolites.2021; 11(12): 882.     CrossRef
  • Synthetic Chemicals and Cardiometabolic Health Across the Life Course Among Vulnerable Populations: a Review of the Literature from 2018 to 2019
    Symielle A. Gaston, Linda S. Birnbaum, Chandra L. Jackson
    Current Environmental Health Reports.2020; 7(1): 30.     CrossRef
  • Bisphenol A analogues (BPS and BPF) present a greater obesogenic capacity in 3T3-L1 cell line
    M.Á. Martínez, J. Blanco, J. Rovira, V. Kumar, J.L. Domingo, M. Schuhmacher
    Food and Chemical Toxicology.2020; 140: 111298.     CrossRef
  • Urinary bisphenol A and its analogues and haemato-biochemical alterations of pregnant women in Korea
    Sora Kang, Bo Hye Shin, Jeoung A Kwon, Chan Wha Lee, Eun Kyo Park, Eun Young Park, Byungmi Kim
    Environmental Research.2020; 182: 109104.     CrossRef
  • Historical exposure to non-persistent environmental pollutants and risk of type 2 diabetes in a Spanish sub-cohort from the European Prospective Investigation into Cancer and Nutrition study
    E. Salamanca-Fernández, L.M. Iribarne-Durán, M. Rodríguez-Barranco, F. Vela-Soria, N. Olea, M.J. Sánchez-Pérez, J.P. Arrebola
    Environmental Research.2020; 185: 109383.     CrossRef
  • Association Between Bisphenol A Exposure and Risk of All-Cause and Cause-Specific Mortality in US Adults
    Wei Bao, Buyun Liu, Shuang Rong, Susie Y. Dai, Leonardo Trasande, Hans-Joachim Lehmler
    JAMA Network Open.2020; 3(8): e2011620.     CrossRef
  • Using three statistical methods to analyze the association between exposure to 9 compounds and obesity in children and adolescents: NHANES 2005-2010
    Bangsheng Wu, Yi Jiang, Xiaoqing Jin, Li He
    Environmental Health.2020;[Epub]     CrossRef
  • How was the Diabetes Metabolism Journal added to MEDLINE?
    Hye Jin Yoo
    Science Editing.2020; 7(2): 201.     CrossRef
  • Adipogenic effects of prenatal exposure to bisphenol S (BPS) in adult F1 male mice
    Young-Ah Ahn, Hwayoung Baek, Miso Choi, Junbo Park, Soo Jin Son, Hyun Ju Seo, Jaeyun Jung, Je Kyung Seong, Jaehyouk Lee, Sungkyoon Kim
    Science of The Total Environment.2020; 728: 138759.     CrossRef
  • Bisphenol A Analogues in Food and Their Hormonal and Obesogenic Effects: A Review
    Andújar, Gálvez-Ontiveros, Zafra-Gómez, Rodrigo, Álvarez-Cubero, Aguilera, Monteagudo, Rivas
    Nutrients.2019; 11(9): 2136.     CrossRef
  • Toxicological considerations of nano-sized plastics
    PA Stapleton
    AIMS Environmental Science.2019; 6(5): 367.     CrossRef
  • Bisphenol A and adiposity measures in peripubertal boys from the INMA-Granada cohort
    Vicente Mustieles, Maribel Casas, Patricia Ferrando-Marco, Olga Ocón-Hernández, Iris Reina-Pérez, Andrea Rodríguez-Carrillo, Fernando Vela-Soria, Rocío Pérez-Lobato, Eva María Navarrete-Muñoz, Carmen Freire, Nicolás Olea, Mariana F. Fernández
    Environmental Research.2019; 173: 443.     CrossRef
  • Trends and disparities in urinary BPA concentrations among U.S. emerging adults
    Irene van Woerden, Meg Bruening, Jessica Montresor-López, Devon C. Payne-Sturges
    Environmental Research.2019; 176: 108515.     CrossRef
  • Concern about the Safety of Bisphenol A Substitutes
    Min Kyong Moon
    Diabetes & Metabolism Journal.2019; 43(1): 46.     CrossRef
  • Urinary Bisphenols and Obesity Prevalence Among U.S. Children and Adolescents
    Melanie H Jacobson, Miriam Woodward, Wei Bao, Buyun Liu, Leonardo Trasande
    Journal of the Endocrine Society.2019; 3(9): 1715.     CrossRef
Epidemiology
High Proportion of Adult Cases and Prevalence of Metabolic Syndrome in Type 1 Diabetes Mellitus Population in Korea: A Nationwide Study
You-Bin Lee, Kyungdo Han, Bongsung Kim, Sang-Man Jin, Seung-Eun Lee, Ji Eun Jun, Jiyeon Ahn, Gyuri Kim, Jae Hyeon Kim
Diabetes Metab J. 2019;43(1):76-89.   Published online August 22, 2018
DOI: https://doi.org/10.4093/dmj.2018.0048
  • 5,799 View
  • 107 Download
  • 26 Web of Science
  • 30 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

The prevalence and incidence of type 1 diabetes mellitus (T1DM) in all age groups and the prevalence of metabolic syndrome in patients with T1DM in Korea were estimated.

Methods

The incidence and prevalence of T1DM between 2007 and 2013 were calculated using the Korean National Health Insurance Service (NHIS) datasets of claims. Clinical characteristics and prevalence of metabolic syndrome in individuals with T1DM between 2009 and 2013 were determined using the database of NHIS preventive health checkups.

Results

The prevalence of T1DM in Korea between 2007 and 2013 was 0.041% to 0.047%. The annual incidence rate of T1DM in Korea in 2007 to 2013 was 2.73 to 5.02/100,000 people. Although the incidence rate of typical T1DM was highest in teenagers, it remained steady in adults over 30 years of age. In contrast, the incidence rate of atypical T1DM in 2013 was higher in people aged 40 years or older than in younger age groups. Age- and sex-adjusted prevalence of metabolic syndrome in patients with T1DM was 51.65% to 55.06% between 2009 and 2013.

Conclusion

T1DM may be more common in Korean adults than previously believed. Metabolic syndrome may be a frequent finding in individuals with T1DM in Korea.

Citations

Citations to this article as recorded by  
  • Increased risk of incident mental disorders in adults with new-onset type 1 diabetes diagnosed after the age of 19: A nationwide cohort study
    Seohyun Kim, Gyuri Kim, So Hyun Cho, Rosa Oh, Ji Yoon Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
    Diabetes & Metabolism.2024; 50(1): 101505.     CrossRef
  • Incidence and trends of type 1 diabetes before and after 2000 in the Western Pacific Region: A systematic review and meta-analysis
    Du Wang, Xiaoli Hou, Juan Huang, Jianjing Sun, Takashi Kadowaki, Moon-Kyu Lee, Alicia J. Jenkins, Linong Ji
    Diabetes Research and Clinical Practice.2024; 207: 111055.     CrossRef
  • The emergence of obesity in type 1 diabetes
    Martin T. W. Kueh, Nicholas W. S. Chew, Ebaa Al-Ozairi, Carel W. le Roux
    International Journal of Obesity.2024; 48(3): 289.     CrossRef
  • Prevalence of Metabolic Syndrome and Its Risk Factors Influence on Microvascular Complications in Patients With Type 1 and Type 2 Diabetes Mellitus
    Asad Riaz, Shoaib Asghar, Salman Shahid, Haider Tanvir, Muhammad Hamza Ejaz, Mamuna Akram
    Cureus.2024;[Epub]     CrossRef
  • Risk of Depression according to Cumulative Exposure to a Low-Household Income Status in Individuals with Type 2 Diabetes Mellitus: A Nationwide Population- Based Study
    So Hee Park, You-Bin Lee, Kyu-na Lee, Bongsung Kim, So Hyun Cho, So Yoon Kwon, Jiyun Park, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2024; 48(2): 290.     CrossRef
  • Comparison of Insulin-Treated Patients with Ambiguous Diabetes Type with Definite Type 1 and Type 2 Diabetes Mellitus Subjects: A Clinical Perspective
    Insa Laspe, Juris J. Meier, Michael A. Nauck
    Diabetes & Metabolism Journal.2023; 47(1): 140.     CrossRef
  • Clinical and biochemical profile of childhood–adolescent-onset type 1 diabetes and adult-onset type 1 diabetes among Asian Indians
    Viswanathan Mohan, Ganesan Uma Sankari, Anandakumar Amutha, Ranjit Mohan Anjana, Saravanan Jeba Rani, Ranjit Unnikrishnan, Ulagamathesan Venkatesan, Coimbatore Subramanian Shanthi Rani
    Acta Diabetologica.2023; 60(4): 579.     CrossRef
  • Subtypes of type 2 diabetes and their association with outcomes in Korean adults - A cluster analysis of community-based prospective cohort
    You-Cheol Hwang, Hong-Yup Ahn, Ji Eun Jun, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung
    Metabolism.2023; 141: 155514.     CrossRef
  • Insulin Fact Sheet in Type 1 and 2 Diabetes Mellitus and Trends of Antidiabetic Medication Use in Insulin Users with Type 2 Diabetes Mellitus: 2002 to 2019
    Jiyun Park, Gyuri Kim, Bong-Sung Kim, Kyung-Do Han, So Yoon Kwon, So Hee Park, You-Bin Lee, Sang-Man Jin, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2023; 47(2): 211.     CrossRef
  • Insulin resistance is more frequent in type 1 diabetes patients with long disease duration
    Yuting Xie, Mei Shi, Xiaolin Ji, Fansu Huang, Li Fan, Xia Li, Zhiguang Zhou
    Diabetes/Metabolism Research and Reviews.2023;[Epub]     CrossRef
  • Long-term Effectiveness of the National Diabetes Quality Assessment Program in South Korea
    Ji Hye Huh, Serim Kwon, Gui Ok Kim, Bo Yeon Kim, Kyoung Hwa Ha, Dae Jung Kim
    Diabetes Care.2023; 46(9): 1700.     CrossRef
  • Low Household Income Status and Death from Pneumonia in People with Type 2 Diabetes Mellitus: A Nationwide Study
    You-Bin Lee, So Hee Park, Kyu-na Lee, Bongsung Kim, So Yoon Kwon, Jiyun Park, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2023; 47(5): 682.     CrossRef
  • Impact of statin treatment on cardiovascular risk in patients with type 1 diabetes: a population-based cohort study
    Joonsang Yoo, Jimin Jeon, Minyoul Baek, Sun Ok Song, Jinkwon Kim
    Journal of Translational Medicine.2023;[Epub]     CrossRef
  • Association between Metabolic Syndrome and Microvascular Complications in Chinese Adults with Type 1 Diabetes Mellitus
    Qianwen Huang, Daizhi Yang, Hongrong Deng, Hua Liang, Xueying Zheng, Jinhua Yan, Wen Xu, Xiangwen Liu, Bin Yao, Sihui Luo, Jianping Weng
    Diabetes & Metabolism Journal.2022; 46(1): 93.     CrossRef
  • The Incidence of Adult-Onset Type 1 Diabetes: A Systematic Review From 32 Countries and Regions
    Jessica L. Harding, Pandora L. Wander, Xinge Zhang, Xia Li, Suvi Karuranga, Hongzhi Chen, Hong Sun, Yuting Xie, Richard A. Oram, Dianna J. Magliano, Zhiguang Zhou, Alicia J. Jenkins, Ronald C.W. Ma
    Diabetes Care.2022; 45(4): 994.     CrossRef
  • Age at Diagnosis and the Risk of Diabetic Nephropathy in Young Patients with Type 1 Diabetes Mellitus
    Jong Ha Baek, Woo Je Lee, Byung-Wan Lee, Soo Kyoung Kim, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2021; 45(1): 46.     CrossRef
  • Genomic ancestry and metabolic syndrome in individuals with type 1 diabetes from an admixed population: a multicentre, cross‐sectional study in Brazil
    B. S. V. Barros, D. C. Santos, L. G. N. Melo, M. H. Pizarro, L. H. Muniz, D. A. Silva, L. C. Porto, M. B. Gomes
    Diabetic Medicine.2021;[Epub]     CrossRef
  • The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes
    Amira Kohil, Maha Al-Asmakh, Mashael Al-Shafai, Annalisa Terranegra
    Frontiers in Nutrition.2021;[Epub]     CrossRef
  • Risk of early mortality and cardiovascular disease according to the presence of recently diagnosed diabetes and requirement for insulin treatment: A nationwide study
    You‐Bin Lee, Kyungdo Han, Bongsung Kim, Min Sun Choi, Jiyun Park, Minyoung Kim, Sang‐Man Jin, Kyu Yeon Hur, Gyuri Kim, Jae Hyeon Kim
    Journal of Diabetes Investigation.2021; 12(10): 1855.     CrossRef
  • Age at Diagnosis and the Risk of Diabetic Nephropathy in Young Patients with Type 1 Diabetes Mellitus (Diabetes Metab J 2021;45:46-54)
    Ye Seul Yang, Tae Seo Sohn
    Diabetes & Metabolism Journal.2021; 45(2): 277.     CrossRef
  • Comparison of fracture risk between type 1 and type 2 diabetes: a comprehensive real-world data
    J. Ha, C. Jeong, K.-D. Han, Y. Lim, M.K. Kim, H.-S. Kwon, K.-H. Song, M.I. Kang, K.-H. Baek
    Osteoporosis International.2021; 32(12): 2543.     CrossRef
  • Early mortality and cardiovascular disease, varied association with body mass index and its changes in insulin-treated diabetes: a nationwide study
    You-Bin Lee, Bongsung Kim, Jiyun Park, Minyoung Kim, Min Sun Choi, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim
    International Journal of Obesity.2021; 45(11): 2482.     CrossRef
  • Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need
    Ye Seul Yang, Kyungdo Han, Tae Seo Sohn, Nam Hoon Kim
    The Korean Journal of Internal Medicine.2021; 36(5): 1049.     CrossRef
  • Positive association between the ratio of triglycerides to high-density lipoprotein cholesterol and diabetes incidence in Korean adults
    Joungyoun Kim, Sang-Jun Shin, Ye-Seul Kim, Hee-Taik Kang
    Cardiovascular Diabetology.2021;[Epub]     CrossRef
  • Mortality and causes of death in a population with blindness in Korea: A longitudinal follow-up study using a national sample cohort
    Hyo Geun Choi, Min Joung Lee, Sang-Mok Lee
    Scientific Reports.2020;[Epub]     CrossRef
  • Hospitalization for heart failure incidence according to the transition in metabolic health and obesity status: a nationwide population-based study
    You-Bin Lee, Da Hye Kim, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Kyungdo Han, Hye Jin Yoo
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Management of Type 1 Diabetes Mellitus in Adults
    Hye Ryoung Yun
    The Journal of Korean Diabetes.2020; 21(3): 156.     CrossRef
  • New Insulin Pumps and Open Source Artificial Pancreas System in Korea
    Jae Hyeon Kim
    The Journal of Korean Diabetes.2020; 21(4): 197.     CrossRef
  • Risk of early mortality and cardiovascular disease in type 1 diabetes: a comparison with type 2 diabetes, a nationwide study
    You-Bin Lee, Kyungdo Han, Bongsung Kim, Seung-Eun Lee, Ji Eun Jun, Jiyeon Ahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • Risk of end‐stage renal disease from chronic kidney disease defined by decreased glomerular filtration rate in type 1 diabetes: A comparison with type 2 diabetes and the effect of metabolic syndrome
    You‐Bin Lee, Kyungdo Han, Bongsung Kim, Ji Eun Jun, Seung‐Eun Lee, Jiyeon Ahn, Gyuri Kim, Sang‐Man Jin, Jae Hyeon Kim
    Diabetes/Metabolism Research and Reviews.2019;[Epub]     CrossRef
Epidemiology
Projection of Diabetes Prevalence in Korean Adults for the Year 2030 Using Risk Factors Identified from National Data
Inkyung Baik
Diabetes Metab J. 2019;43(1):90-96.   Published online October 31, 2018
DOI: https://doi.org/10.4093/dmj.2018.0043
  • 3,884 View
  • 44 Download
  • 15 Web of Science
  • 15 Crossref
AbstractAbstract PDFPubReader   
Background

A number of studies have reported future prevalence estimates for diabetes mellitus (DM), but these studies have been limited for the Korean population. The present study aimed to construct a forecasting model that includes risk factors for type 2 DM using individual- and national-level data for Korean adults to produce prevalence estimates for the year 2030.

Methods

Time series data from the Korea National Health and Nutrition Examination Survey and national statistics from 2005 to 2013 were used. The study subjects were 13,908 male and 18,697 female adults aged 30 years or older who were free of liver cirrhosis. Stepwise logistic regression analysis was used to select significant factors associated with DM prevalence.

Results

The results showed that survey year, age, sex, marital, educational, or occupational status, the presence of obesity or hypertension, smoking status, alcohol consumption, sleep duration, psychological distress or depression, and fertility rate significantly contributed to the 8-year trend in DM prevalence (P<0.05). Based on sex-specific forecasting models that included the above factors, DM prevalence for the year 2030 was predicted to be 29.2% (95% confidence interval [CI], 27.6% to 30.8%) in men and 19.7% (95% CI, 18.2% to 21.2%) in women.

Conclusion

The present study projected a two-fold increase in the prevalence of DM in 2030 compared with that for the years 2013 and 2014 in Korean adults. Modifiable factors contributing to this increase in DM prevalence, such as obesity, smoking, and psychological factors, may require attention in order to reduce national and individual costs associated with DM.

Citations

Citations to this article as recorded by  
  • Angiotensin‐converting enzyme inhibitors versus angiotensin receptor blockers: New‐onset diabetes mellitus stratified by statin use
    Juyoung Shin, Hyunah Kim, Hyeon Woo Yim, Ju Han Kim, Suehyun Lee, Hun‐Sung Kim
    Journal of Clinical Pharmacy and Therapeutics.2022; 47(1): 97.     CrossRef
  • Sleep duration and mortality in patients with diabetes: Results from the 2007–2015 Korea national health and nutrition examination survey
    Kang-Mo Gu, Se Hee Min, Jaeyoung Cho
    Diabetes & Metabolism.2022; 48(3): 101312.     CrossRef
  • Advances in the use of electrospinning as a promising technique for obtaining nanofibers to guide epithelial wound healing in diabetics—Mini‐review
    Pamela Roberta Alves da Costa, Lívia Rodrigues de Menezes, Marcos Lopes Dias, Emerson Oliveira da Silva
    Polymers for Advanced Technologies.2022; 33(4): 1031.     CrossRef
  • GLP-1 receptor agonists in diabetic kidney disease: current evidence and future directions
    Ji Hee Yu, So Young Park, Da Young Lee, Nan Hee Kim, Ji A Seo
    Kidney Research and Clinical Practice.2022; 41(2): 136.     CrossRef
  • Associations between obesity, metabolic syndrome, and endometrial cancer risk in East Asian women
    Boyoung Park
    Journal of Gynecologic Oncology.2022;[Epub]     CrossRef
  • Hemoglobin glycation index is associated with incident chronic kidney disease in subjects with impaired glucose metabolism: A 10-year longitudinal cohort study
    Wonjin Kim, Taehwa Go, Dae Ryong Kang, Eun Jig Lee, Ji Hye Huh
    Journal of Diabetes and its Complications.2021; 35(1): 107760.     CrossRef
  • A Novel User Utility Score for Diabetes Management Using Tailored Mobile Coaching: Secondary Analysis of a Randomized Controlled Trial
    Min-Kyung Lee, Da Young Lee, Hong-Yup Ahn, Cheol-Young Park
    JMIR mHealth and uHealth.2021; 9(2): e17573.     CrossRef
  • Development of a clinical risk score for incident diabetes: A 10‐year prospective cohort study
    Tae Jung Oh, Jae Hoon Moon, Sung Hee Choi, Young Min Cho, Kyong Soo Park, Nam H Cho, Hak Chul Jang
    Journal of Diabetes Investigation.2021; 12(4): 610.     CrossRef
  • Antiobesity and Antidiabetic Effects of Portulaca oleracea Powder Intake in High-Fat Diet-Induced Obese C57BL/6 Mice
    Jae Hyun Jung, Su Bin Hwang, Hyeon Ju Park, Guang-Ri Jin, Bog Hieu Lee, Rômulo Dias Novaes
    Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1.     CrossRef
  • Spironolactone Attenuates Methylglyoxal-induced Cellular Dysfunction in MC3T3-E1 Osteoblastic Cells
    So Young Park, Kwang Sik Suh, Woon-Won Jung, Sang Ouk Chin
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Smoking as a Target for Prevention of Diabetes
    Ye Seul Yang, Tae Seo Sohn
    Diabetes & Metabolism Journal.2020; 44(3): 402.     CrossRef
  • Prognosis of Patients with Colorectal Cancer with Diabetes According to Medication Adherence: A Population-Based Cohort Study
    Sunho Choe, Joonki Lee, Ji Won Park, Seung-Yong Jeong, Young Min Cho, Byung-Joo Park, Aesun Shin
    Cancer Epidemiology, Biomarkers & Prevention.2020; 29(6): 1120.     CrossRef
  • Potential Diagnostic Hemorheological Indexes for Chronic Kidney Disease in Patients With Type 2 Diabetes
    Hoyoon Lee, Wonwhi Na, Sang Bae Lee, Chul Woo Ahn, Jun Sung Moon, Kyu Chang Won, Sehyun Shin
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • Response: Projection of Diabetes Prevalence in Korean Adults for the Year 2030 Using Risk Factors Identified from National Data (Diabetes Metab J 2019;43:90–6)
    Inkyung Baik
    Diabetes & Metabolism Journal.2019; 43(2): 244.     CrossRef
  • Letter: Projection of Diabetes Prevalence in Korean Adults for the Year 2030 Using Risk Factors Identified from National Data (Diabetes Metab J 2019;43:90–6)
    Bo Kyung Koo
    Diabetes & Metabolism Journal.2019; 43(2): 242.     CrossRef
Complication
Soluble Dipeptidyl Peptidase-4 Levels Are Associated with Decreased Renal Function in Patients with Type 2 Diabetes Mellitus
Eun-Hee Cho, Sang-Wook Kim
Diabetes Metab J. 2019;43(1):97-104.   Published online October 8, 2018
DOI: https://doi.org/10.4093/dmj.2018.0030
  • 4,192 View
  • 52 Download
  • 13 Web of Science
  • 13 Crossref
AbstractAbstract PDFPubReader   
Background

Dipeptidyl peptidase-4 (DPP-4) is strongly expressed in the kidney, and soluble levels of this protein are used as a marker in various chronic inflammatory diseases, including diabetes, coronary artery disease, and cancer. This study examined the association between the serum soluble DPP-4 levels and renal function or cardiovascular risk in patients with type 2 diabetes mellitus.

Methods

In this retrospective analysis, soluble DPP-4 levels were measured in preserved sera from 140 patients with type 2 diabetes mellitus who had participated in our previous coronary artery calcium (CAC) score study.

Results

The mean±standard deviation soluble DPP-4 levels in our study sample were 645±152 ng/mL. Univariate analyses revealed significant correlations of soluble DPP-4 levels with the total cholesterol (r=0.214, P=0.019) and serum creatinine levels (r=−0.315, P<0.001) and the estimated glomerular filtration rate (eGFR; estimated using the modification of diet in renal disease equation) (r=0.303, P=0.001). The associations of soluble DPP-4 levels with serum creatinine and GFR remained significant after adjusting for age, body mass index, and duration of diabetes. However, no associations were observed between soluble DPP-4 levels and the body mass index, waist circumference, or CAC score.

Conclusion

These data suggest the potential use of serum soluble DPP-4 levels as a future biomarker of deteriorated renal function in patients with type 2 diabetes mellitus.

Citations

Citations to this article as recorded by  
  • Sitagliptin Mitigates Diabetic Nephropathy in a Rat Model of Streptozotocin-Induced Type 2 Diabetes: Possible Role of PTP1B/JAK-STAT Pathway
    Sarah M. AL-Qabbaa, Samaher I. Qaboli, Tahani K. Alshammari, Maha A. Alamin, Haya M. Alrajeh, Lama A. Almuthnabi, Rana R. Alotaibi, Asma S. Alonazi, Anfal F. Bin Dayel, Nawal M. Alrasheed, Nouf M. Alrasheed
    International Journal of Molecular Sciences.2023; 24(7): 6532.     CrossRef
  • Evaluation of the efficacy of dipeptidyl peptidase-4 enzyme and selenium element in people with kidney failure in Kirkuk governorate
    Ibrahim Abdullah Ali Al-Jubouri, Nadia Ahmed Saleh Al-Jubouri
    Materials Today: Proceedings.2022; 60: 795.     CrossRef
  • Cardiovascular Effects of Incretin-Based Therapies: Integrating Mechanisms With Cardiovascular Outcome Trials
    John R. Ussher, Amanda A. Greenwell, My-Anh Nguyen, Erin E. Mulvihill
    Diabetes.2022; 71(2): 173.     CrossRef
  • Computer-Aided Screening of Phytoconstituents from Ocimum tenuiflorum against Diabetes Mellitus Targeting DPP4 Inhibition: A Combination of Molecular Docking, Molecular Dynamics, and Pharmacokinetics Approaches
    Harshit Sajal, Shashank M. Patil, Ranjith Raj, Abdullah M. Shbeer, Mohammed Ageel, Ramith Ramu
    Molecules.2022; 27(16): 5133.     CrossRef
  • Association Between DPP4 Inhibitor Use and the Incidence of Cirrhosis, ESRD, and Some Cancers in Patients With Diabetes
    Yewon Na, Soo Wan Kim, Ie Byung Park, Soo Jung Choi, Seungyoon Nam, Jaehun Jung, Dae Ho Lee
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(11): 3022.     CrossRef
  • An update on the interaction between COVID-19, vaccines, and diabetic kidney disease
    Yang Yang, Shubiao Zou, Gaosi Xu
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Comparative Efficacy of Lobeglitazone Versus Pioglitazone on Albuminuria in Patients with Type 2 Diabetes Mellitus
    Kyung-Soo Kim, Sangmo Hong, Hong-Yup Ahn, Cheol-Young Park
    Diabetes Therapy.2021; 12(1): 171.     CrossRef
  • Renoprotective Effects of DPP-4 Inhibitors
    Daiji Kawanami, Yuichi Takashi, Hiroyuki Takahashi, Ryoko Motonaga, Makito Tanabe
    Antioxidants.2021; 10(2): 246.     CrossRef
  • Serum levels of soluble dipeptidyl peptidase-4 in type 2 diabetes are associated with severity of liver fibrosis evaluated by transient elastography (FibroScan) and the FAST (FibroScan-AST) score, a novel index of non-alcoholic steatohepatitis with signif
    Masaaki Sagara, Toshie Iijima, Masato Kase, Kanako Kato, Shintaro Sakurai, Takuya Tomaru, Teruo Jojima, Isao Usui, Yoshimasa Aso
    Journal of Diabetes and its Complications.2021; 35(5): 107885.     CrossRef
  • Distinctive CD26 Expression on CD4 T-Cell Subsets
    Oscar J. Cordero, Carlos Rafael-Vidal, Rubén Varela-Calviño, Cristina Calviño-Sampedro, Beatriz Malvar-Fernández, Samuel García, Juan E. Viñuela, José M. Pego-Reigosa
    Biomolecules.2021; 11(10): 1446.     CrossRef
  • The Long-Term Study of Urinary Biomarkers of Renal Injury in Spontaneously Hypertensive Rats
    Sebastián Montoro-Molina, Andrés Quesada, Francisco O’Valle, Natividad Martín Morales, María del Carmen de Gracia, Isabel Rodríguez-Gómez, Antonio Osuna, Rosemary Wangensteen, Félix Vargas
    Kidney and Blood Pressure Research.2021; 46(4): 502.     CrossRef
  • Serum Dipeptidyl peptidase-4 level is related to adiposity in type 1 diabetic adolescents
    Amany Ibrahim, Shaimaa Salah, Mona Attia, Hanan Madani, Samah Ahmad, Noha Arafa, Hend Soliman
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(4): 609.     CrossRef
  • Phase I study of YS110, a recombinant humanized monoclonal antibody to CD26, in Japanese patients with advanced malignant pleural mesothelioma
    Masayuki Takeda, Yuichiro Ohe, Hidehito Horinouchi, Toyoaki Hida, Junichi Shimizu, Takashi Seto, Kaname Nosaki, Takumi Kishimoto, Itaru Miyashita, Masayuki Yamada, Yutaro Kaneko, Chikao Morimoto, Kazuhiko Nakagawa
    Lung Cancer.2019; 137: 64.     CrossRef
Obesity and Metabolic Syndrome
Proportion and Characteristics of the Subjects with Low Muscle Mass and Abdominal Obesity among the Newly Diagnosed and Drug-Naïve Type 2 Diabetes Mellitus Patients
Jung A Kim, Soon Young Hwang, Hye Soo Chung, Nam Hoon Kim, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo
Diabetes Metab J. 2019;43(1):105-113.   Published online September 28, 2018
DOI: https://doi.org/10.4093/dmj.2018.0036
  • 4,822 View
  • 70 Download
  • 12 Web of Science
  • 14 Crossref
AbstractAbstract PDFPubReader   
Background

Sarcopenic obesity (SO) is a serious public health concern, few studies have examined the clinical implications of SO in newly-diagnosed type 2 diabetes mellitus (T2DM) patients. We evaluated the prevalence of the newly diagnosed, drug-naïve T2DM patients with low muscle mass with abdominal obesity and its association with insulin resistance and other diabetic complications.

Methods

We classified 233 drug-naïve T2DM subjects into four groups according to abdominal obesity (waist circumference ≥90 cm in men and ≥85 cm in women) and low muscle mass status (appendicular skeletal muscle <7.0 kg/m2 for men and <5.4 kg/m2 for women).

Results

The proportion of the subjects with low muscle mass and abdominal obesity among the newly diagnosed, drug-naïve T2DM patients was 8.2%. Homeostasis model assessment of insulin resistance (HOMA-IR) increased linearly according to body composition group from normal to abdominal obesity to both low muscle mass and abdominal obesity. The multiple logistic regression analysis indicated that subjects with low muscle mass and abdominal obesity (odds ratio [OR], 9.39; 95% confidence interval [CI], 2.41 to 36.56) showed a higher risk for insulin resistance, defined as HOMA-IR ≥3, than those with abdominal obesity (OR, 5.36; 95% CI, 2.46 to 11.69), even after adjusting for other covariates. However, there were no differences in lipid profiles, microalbuminuria, or various surrogate markers for atherosclerosis among the four groups.

Conclusion

Subjects with both low muscle mass and abdominal obesity had a higher risk of insulin resistance than those with low muscle mass or abdominal obesity only.

Citations

Citations to this article as recorded by  
  • Clinical observation on acupuncture for 80 patients with abdominal obesity in Germany: based on the theory of unblocking and regulating the Belt Vessel
    Yuanyuan Li, Hang Xiong, Shuhui Ma, Jingzhang Dai
    Journal of Acupuncture and Tuina Science.2023; 21(2): 137.     CrossRef
  • Waist circumference and end‐stage renal disease based on glycaemic status: National Health Insurance Service data 2009–2018
    Yun Kyung Cho, Ji Hye Huh, Shinje Moon, Yoon Jung Kim, Yang‐Hyun Kim, Kyung‐do Han, Jun Goo Kang, Seong Jin Lee, Sung‐Hee Ihm
    Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 585.     CrossRef
  • Incidence of sarcopenic obesity in older patients with diabetes and association between sarcopenic obesity and higher-level functional capacity: evaluation based on a consensus statement
    Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, Kaoru Okubo, Kentaro Azuma, Kazuya Murata
    Endocrine Journal.2023; 70(6): 591.     CrossRef
  • A Novel Anthropometric Parameter, Weight-Adjusted Waist Index Represents Sarcopenic Obesity in Newly Diagnosed Type 2 Diabetes Mellitus
    Min Jeong Park, Soon Young Hwang, Nam Hoon Kim, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo
    Journal of Obesity & Metabolic Syndrome.2023; 32(2): 130.     CrossRef
  • Prevalence of sarcopenic obesity in patients with diabetes and adverse outcomes: A systematic review and meta-analysis
    Yuan-yuan Zhou, Jin-feng Wang, Qian Yao, Qiu-feng Jian, Zhi-peng Luo
    Clinical Nutrition ESPEN.2023; 58: 128.     CrossRef
  • The Correlation Between Leg Muscle Mass Index and Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus
    Menggege Liu, Qing Zhang, Juan Liu, Huiling Bai, Ping Yang, Xinhua Ye, Xiaoqing Yuan
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 4169.     CrossRef
  • Sarcopenic Obesity with Normal Body Size May Have Higher Insulin Resistance in Elderly Patients with Type 2 Diabetes Mellitus
    Tingting Han, Ting Yuan, Xinyue Liang, Ningxin Chen, Jia Song, Xin Zhao, Yurong Weng, Yaomin Hu
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 1197.     CrossRef
  • Relationship between Visceral Adipose Index, Lipid Accumulation Product and Type 2 Diabetes Mellitus
    停停 陈
    Advances in Clinical Medicine.2022; 12(04): 3350.     CrossRef
  • Assessment of the relationship between prediabetes and low skeletal mass based on blood creatinine level
    S. I. Ibragimova, G. O. Nuskabayeva, Z. N. Shalkharova, K. Zh. Sadykova, G. A. Junusbekova, M. Oran
    Diabetes mellitus.2022; 25(3): 226.     CrossRef
  • Changes in body composition and low blood urea nitrogen level related to an increase in the prevalence of fatty liver over 20 years: A cross‐sectional study
    Yasushi Imamura, Seiichi Mawatari, Kohei Oda, Kotaro Kumagai, Yasunari Hiramine, Akiko Saishoji, Atsuko Kakihara, Mai Nakahara, Manei Oku, Kaori Hosoyamada, Shuji Kanmura, Akihiro Moriuchi, Hironori Miyahara, Akio ido
    Hepatology Research.2021; 51(5): 570.     CrossRef
  • Body Composition and Diabetes
    Hye Jin Yoo
    The Journal of Korean Diabetes.2021; 22(4): 238.     CrossRef
  • Reduced Skeletal Muscle Volume and Increased Skeletal Muscle Fat Deposition Characterize Diabetes in Individuals after Pancreatitis: A Magnetic Resonance Imaging Study
    Andre E. Modesto, Juyeon Ko, Charlotte E. Stuart, Sakina H. Bharmal, Jaelim Cho, Maxim S. Petrov
    Diseases.2020; 8(3): 25.     CrossRef
  • Low alanine aminotransferase levels predict low muscle strength in older patients with diabetes: A nationwide cross‐sectional study in Korea
    Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
    Geriatrics & Gerontology International.2020; 20(4): 271.     CrossRef
  • Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis
    Dima Khadra, Leila Itani, Hana Tannir, Dima Kreidieh, Dana El Masri, Marwan El Ghoch
    World Journal of Diabetes.2019; 10(5): 311.     CrossRef
Obesity and Metabolic Syndrome
Higher High Density Lipoprotein 2 (HDL2) to Total HDL Cholesterol Ratio Is Associated with a Lower Risk for Incident Hypertension
You-Cheol Hwang, Wilfred Y. Fujimoto, Steven E. Kahn, Donna L. Leonetti, Edward J. Boyko
Diabetes Metab J. 2019;43(1):114-122.   Published online September 28, 2018
DOI: https://doi.org/10.4093/dmj.2018.0053
  • 4,176 View
  • 46 Download
  • 6 Web of Science
  • 10 Crossref
AbstractAbstract PDFPubReader   
Background

Recent studies have suggested that high density lipoprotein (HDL) cholesterol is inversely associated with the development of hypertension. We aimed to determine the association between different HDL cholesterol subclasses and risk of future hypertension.

Methods

A total of 270 Japanese Americans (130 men, 140 women) without hypertension between the ages of 34 to 75 years were enrolled. Blood pressure was measured with a mercury sphygmomanometer, and average blood pressure was calculated. Incident hypertension was determined 5 to 6 and 10 to 11 years after enrollment. HDL2, HDL3, and total HDL cholesterol were measured at baseline.

Results

During 10 years of follow-up, the cumulative incidence of hypertension was 28.1% (76/270). In univariate analysis, age, diabetes, waist circumference, systolic and diastolic blood pressure, fasting glucose, insulin resistance index, total and low density lipoprotein cholesterol, and visceral adipose tissue were significant predictors for incident hypertension. Among the HDL cholesterol subclass, HDL2 cholesterol was inversely associated with hypertension incidence, but both total and HDL3 cholesterol were not. In addition, HDL2/HDL cholesterol was inversely associated with future hypertension risk. In multivariate analysis, age (odds ratio [OR], 1.71; 95% confidence interval [CI], 1.26 to 2.31; P=0.001), systolic blood pressure (OR, 1.83; 95% CI, 1.31 to 2.56; P<0.001), and HDL2/HDL cholesterol (OR, 0.71; 95% CI, 0.52 to 0.98; P=0.035), were associated with future development of hypertension.

Conclusion

A higher proportion of HDL2 cholesterol among total HDL cholesterol predicted a lower risk for incident hypertension. However, concentrations of total HDL, HDL2, and HDL3 cholesterol were not independent predictors of incident hypertension.

Citations

Citations to this article as recorded by  
  • The Association of HDL2b with Metabolic Syndrome Among Normal HDL-C Populations in Southern China
    Tong Chen, Shiquan Wu, Ling Feng, SiYu Long, Yu Liu, WenQian Lu, Wenya Chen, Guoai Hong, Li Zhou, Fang Wang, Yuechan Luo, Hequn Zou
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 363.     CrossRef
  • Long-term PM1 exposure and hypertension hospitalization: A causal inference study on a large community-based cohort in South China
    Yuqin Zhang, Shirui Chen, Jing Wei, Jie Jiang, Xiao Lin, Ying Wang, Chun Hao, Wenjing Wu, Zhupei Yuan, Jie Sun, Han Wang, Zhicheng Du, Wangjian Zhang, Yuantao Hao
    Science Bulletin.2024;[Epub]     CrossRef
  • High-Density Lipoprotein Signaling via Sphingosine-1-Phosphate Receptors Safeguards Spontaneously Hypertensive Rats against Myocardial Ischemia/Reperfusion Injury
    Aishah Al-Jarallah, Fawzi A. Babiker
    Pharmaceutics.2024; 16(4): 497.     CrossRef
  • Effects of cardiometabolic risk factors on blood pressure in outpatients at Sominé DOLO hospital, Mopti, Mali
    Modibo Coulibaly, Adama Kondé, Djibril Traoré, Ousmane Bah, Valentin Sagara, Bakary Maiga
    International Journal of Clinical Biochemistry and Research.2023; 10(1): 87.     CrossRef
  • The association of lipid metabolism with bone metabolism and the role of human traits: a Mendelian randomization study
    Jian Kang, Shuangli Zhao, Xize Wu, Can Wang, Zongkun Jiang, Shixuan Wang
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • The role of different lipid measures for incident hypertension during more than 12-year follow-up: Tehran Lipid and Glucose Study
    Amirreza Hadaegh, Samaneh Akbarpour, Maryam Tohidi, Niloofar Barzegar, Somayeh Hosseinpour-Niazi, Fereidoun Azizi, Farzad Hadaegh
    British Journal of Nutrition.2022; 128(9): 1700.     CrossRef
  • High Density Lipoprotein Reduces Blood Pressure and Protects Spontaneously Hypertensive Rats Against Myocardial Ischemia-Reperfusion Injury in an SR-BI Dependent Manner
    Aishah Al-Jarallah, Fawzi Babiker
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Association between the Uric Acid to High Density Lipoprotein Cholesterol Ratio and Systolic Pressure in Chinese Short Stature Children and Adolescents
    广欣 李
    Advances in Clinical Medicine.2022; 12(09): 8266.     CrossRef
  • Associations Between Peripheral Blood Microbiome and the Risk of Hypertension
    Yang Jing, Hui Zhou, Honghong Lu, Xiaofang Chen, Liangyue Zhou, Jingqi Zhang, Jing Wu, Chen Dong
    American Journal of Hypertension.2021; 34(10): 1064.     CrossRef
  • How was the Diabetes Metabolism Journal added to MEDLINE?
    Hye Jin Yoo
    Science Editing.2020; 7(2): 201.     CrossRef
Letter
Letter: Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans (Diabetes Metab J 2018;42:488–95)
Nan Hee Cho, Hye Soon Kim
Diabetes Metab J. 2019;43(1):123-124.   Published online February 19, 2019
DOI: https://doi.org/10.4093/dmj.2019.0026
  • 2,782 View
  • 34 Download
PDFPubReader   
Response
Response: Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans (Diabetes Metab J 2018;42:488–95)
Seung Jin Han, Edward J. Boyko
Diabetes Metab J. 2019;43(1):125-126.   Published online February 19, 2019
DOI: https://doi.org/10.4093/dmj.2019.0028
  • 2,640 View
  • 33 Download
PDFPubReader   

Diabetes Metab J : Diabetes & Metabolism Journal