Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Previous issues

Page Path
HOME > Browse > Previous issues
11 Previous issues
Filter
Filter
Article category
Keywords
Authors
Volume 30(5); September 2006
Prev issue Next issue
Review
Insulin Resistance and PPARgamma.
Bong Soo Cha, Se Eun Park
Korean Diabetes J. 2006;30(5):317-323.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.317
  • 1,844 View
  • 17 Download
  • 2 Crossref
AbstractAbstract PDF
No abstract available.

Citations

Citations to this article as recorded by  
  • Caulerpa okamuraeethanol extract improves the glucose metabolism and insulin sensitivityin vitroandin vivo
    Chul-Min Park, Laxmi Sen Thakuri, Dong-Young Rhyu
    Journal of Applied Biological Chemistry.2021; 64(1): 89.     CrossRef
  • Impacts of High Sodium Intake on Obesity-related Gene Expression
    Minjee Lee, Miyoung Park, Juhee Kim, Soyoung Sung, Myoungsook Lee
    Journal of the East Asian Society of Dietary Life.2018; 28(5): 364.     CrossRef
Original Articles
Effects of PPAR-alpha and-gamma Agonists on Fatty Acid Metabolism of Muscle Cells in Hyperlipidemic and Hyperglycemic Conditions.
Yong jik Lee, Zheng Shan Zhao, Soo Kyung Kim, Hae Jin Kim, Wan Sub Shim, Chul Woo Ahn, Hyun Chul Lee, Bong Soo Cha
Korean Diabetes J. 2006;30(5):324-335.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.324
  • 2,209 View
  • 24 Download
  • 2 Crossref
AbstractAbstract PDF
BACKGROUND
Studies for the regulation of fatty acid metabolism are deficient relatively in skeletal muscle and heart. The investigations in pathological conditions for malonyl-CoA decarboxylase (MCD) and for the relation of MCD and PPAR-alpha.-gamma agonists are insufficient in particular. METHODS: In the current study, fully differentiated H9c2 muscle cells were exposed to pathological conditions such as hyperlipidemic (0.1 mM Palmitate) and hyperglycemic (16.5 mM Glucose) condition with 5 uM PPAR-gamma agonist (rosiglitazone) and 10 uM PPAR-alpha agonist (WY14,643) and then experiments such as MCD activity assay, MCD real-time RT-PCR, MCD reporter gene assay, MCD Western blotting, PPAR-alpha Western blotting, and palmitate oxidation test were carried out. RESULTS: Only PPAR-alpha agonist increased MCD activity. In the result of real-time RT-PCR, both PPAR-alpha and PPAR-gamma agonists elevated MCD mRNA expression in hyperlipidemic condition. MCD protein expression was decreased in hyperlipidemic condition, however, increased in rosiglitazone, or WY14,643 treated conditions. Rosiglitazone, and WY14,643 treated groups showed incresed MCD protein expression in hyperglycemic condition. Hyperlipidemic control group and PPAR-alpha.-gamma agonists treated groups presented about 3.8 times more increased palmitate oxidation level than normolipidemic control group in hyperlipidemic condition. PPAR-alpha agonist treated group showed 49% more increased palmitate oxidation rate than hyperlipidemic control group in primary cultured rat skeletal muscle cells. The amount of palmitate oxidation from differentiated H9c2 muscle cells that had overexpressed PPAR-alpha structural genes was more increased than control group. CONCLUSION: This study suggests that PPAR-alpha agonist ameliorates the defects induced by hyperlipidemic condition through the regulation of MCD. In summary, a closely reciprocal relation among PPAR-alpha agonist, MCD, and fatty acid oxidation existed distinctly in hyperlipidemic condition, but not in hyperglycemic condition.

Citations

Citations to this article as recorded by  
  • Beneficial effect of Combination with Korean Red Ginseng and Morus alba in metabolic syndrome
    Yun Jung Lee, Hye Yoom Kim, Jung Joo Yoon, So Min Lee, You Mee Ahn, Joung Hyun Kho, Min Chul Kho, Ho Sub Lee, Kyung Min Choi, Dae Gill Kang
    The Korea Journal of Herbology.2012; 27(6): 99.     CrossRef
  • Effects of Mixed Extract from Lycium chinense, Cordyceps militaris, and Acanthopanax senticosus on Glucose-Regulating Enzymes of HepG2 in Hyperglycemic Conditions
    Dae-Jung Kim, Jeong-Mi Kim, Tae-Hyuk Kim, Jong-Mi Baek, Hyun-Sook Kim, Myeon Choe
    Journal of the Korean Society of Food Science and Nutrition.2010; 39(9): 1257.     CrossRef
Inducible Nitric Oxide Synthase (iNOS) Expression in the Hypoxic Injury to Pancreatic Beta (MIN6) Cells.
Seung Hyun Ko, Seung Bum Kim, Kyung Ryul Ryu, Ji Won Kim, Yu Bai Ahn, Sung Dae Moon, Sung Rae Kim, Jung Min Lee, Hyuk Snag Kwon, Kun Ho Yoon, Ki Ho Song
Korean Diabetes J. 2006;30(5):336-346.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.336
  • 2,258 View
  • 20 Download
AbstractAbstract PDF
BACKGROUND
Islet transplantation is an alternative potential strategy to cure type 1 diabetes mellitus. However, two or more donors are usually needed for one recipient because a substantial part of the graft becomes nonfunctional due to several factors including hypoxia. Though hypoxic exposure of pancreatic beta cells has been reported to induce apoptotic cell death, the molecular processes involved in hypoxia-induced cell death are poorly understood. In type I diabetes, Nitric Oxide (NO) is known as an important cytokine, involved in the pathogenesis of beta cell dysfunction. Pancreatic beta cells are sensitive to the induction of inducible nitric oxide synthase (iNOS) when stimulated by TNF-a or IL-1beta. But contribution of iNOS in response to hypoxia is not yet fully understood. METHODS: Mouse insulinoma cells (MIN6) were incubated in an anaerobic chamber (75% N2/15% CO2/5% H2) for up to 12 hours. Cell viability was measured after AO/PI staining. Caspase-3 activation was also determined using Western blot analysis. Nitric Oxide (NO) release into culture medium was measured using a Griess reagent. The expression of iNOS and PDX-1 mRNA and iNOS protein was examined using real time PCR and Western blot analysis. RESULTS: Marked cell death was observed within 6 hours after hypoxic exposure of MIN6 cells (control, < 5%; 2 hr, 11.0+/-7.6%; 6 hr, 46.2+/-12.8%, P < 0.05). Immunoreactivity to activated caspase-3 was observed at 2, 4 and 6 hrs. NO production was increased in a time dependent manner. Expression of iNOS mRNA and protein was significantly increased at 4 and 6 hour after hypoxia. iNOS expression was confirmed by immunostaining. Of note, Pdx-1 mRNA expression was markedly attenuated by hypoxic treatment. Pretreatment with a selective iNOS inhibitor, 1400 W, significantly prevented beta cell death induced by hypoxic injury. CONCLUSION: Our data suggest that iNOS-NO play an important role in hypoxic injury to MIN6 cells. Therefore, iNOS-NO might be a potential therapeutic target for improving engraftment of the transplanted islets and suppression of iNOS would be helpful for prevention of beta cells damage to hypoxic injury.
Relation between Cerebral Arterial Pulsatility and Insulin Resistance in Type 2 Diabetic Patients.
Jong Suk Park, Chul Sik Kim, Hai Jin Kim, Ji Sun Nam, Tae Woong Noh, Chul Woo Ahn, Kyung Yul Lee, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee
Korean Diabetes J. 2006;30(5):347-354.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.347
  • 2,362 View
  • 18 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
Diabetic patients have a 3-fold risk for cerebrovascular disease compared with nondiabetic controls. The aim of the present study was to investigate the association of insulin resistance with pulsatility index (PI) of cerebral arteries in type 2 diabetic patients. METHODS: We compared a group of 90 patients with stroke free, type 2 diabetes and an age- and sex-matched control group of 45 healthy subjects without diabetes. Diabetic patients were divided into 3 groups according to the ISI (insulin sensitivity index). We evaluated PI of the middle cerebral artery (MCA) by transcranial Doppler ultrasonography (TCD) and insulin resistance determined by short insulin tolerance test. RESULTS: The PI was significantly higher in diabetic patients than that in healthy controls (P < 0.05), and also higher in patients with insulin resistance than that in insulin sensitive diabetic patients (P < 0.05). The PI of the MCA was significantly correlated with age (r= 0.465, P < 0.01), duration of diabetes (r = 0.264, P = 0.025), hypertension (r = 0.285, P = 0.015) and inversely correlated with insulin resistance (r = -0.359, P = 0.030).Multiple regression analysis was performed with PI as a dependent variable and insulin resistance as an independent variable along with known clinical risk factors. Age (beta = 0.393, P < 0.01) and duration of diabetes (beta = 0.274, P = 0.043) exhibited a significant independent contribution to PI. CONCLUSIONS: PI might be useful markers of the detection of diabetic cerebrovascular changes and insulin resistance, measured with short insulin tolerance test, showed correlations with PI, but age and duration of diabetes contributed independently to the variability in the PI.

Citations

Citations to this article as recorded by  
  • Factors Affecting Basilar Artery Pulsatility Index on Transcranial Doppler
    Ho Tae Jeong, Dae Sik Kim, Kun Woo Kang, Yun Teak Nam, Ji Eun Oh, Eun Kyung Cho
    The Korean Journal of Clinical Laboratory Science.2018; 50(4): 477.     CrossRef
Current Status of Diabetic End-Stage Renal Disease Using Korean Health Insurance Database.
Dae Jung Kim, Jaiyong Kim, Hyeyoung Kim, Kyung Wan Min, Seok Won Park, Ie Byung Park, Jeong Hyun Park, Sei Hyun Baik, Hyun Shik Son, Chul Woo Ahn, Jee Young Oh, Sunhee Lee, Juneyoung Lee, Choon Hee Chung, Kyung Mook Choi, Injeoung Choi, Hwayoung Kim
Korean Diabetes J. 2006;30(5):355-362.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.355
  • 2,644 View
  • 28 Download
  • 7 Crossref
AbstractAbstract PDF
BACKGROUND
Diabetes is becoming one of the main causes of end-stage renal disease (ESRD) worldwide. We studied the prevalence and incidence of end-stage renal disease (ESRD) in the Korean population based on health insurance claims submitted to the Health Insurance Review Agency. We also investigated the proportion of medications taken by the ESRD patients, and frequency of hospital admission or visits, and medical expenses between ESRD patients with and without diabetes. METHODS: This study was based on health insurance claims submitted to the Health Insurance Review Agency during the period from January 2001 through December 2003. Using the disease-classification codes on the health insurance claim forms, those who were diagnosed with chronic renal disease (N18 or N19) and received dialysis-related treatment (Z49), treatment with a kidney dialysis machine (Z99.2), or kidney transplantation (Z94.0) were defined as ESRD patients. Among the ESRD patients, those who were diagnosed with diabetes (E10-E14) and/or took anti-diabetic drugs were defined as ESRD patients with diabetes. RESULTS: The ESRD patients totaled 33,870 in 2001, 37,894 in 2002, and 41,167 (858.3 per million population) in 2003. ESRD patients with diabetes increased to 56.7% in 2003. The number of ESRD patients in whom renal replacement therapy was initiated was 8,134 in 2002 and 8,322 (173.5 per million population) in 2003. ESRD patients with diabetes used more anti-hypertensive drugs (1.2 times as many), lipid-lowering drugs (1.6 times), and anti-platelet agents (1.8 times) than did ESRD patients without diabetes. In 2003, 66.5% of the ESRD patients with diabetes were hospitalized, which was 1.6 times the hospital admissions of ESRD patients without diabetes. ESRD patients with diabetes also had hospital stays that were 1.6 times longer per patient and inpatient service expenses that were 1.6times greater per patient, compared with those reported for ESRD patients without diabetes. CONCLUSION: The incidence of ESRD accompanied by diabetes has risen rapidly. Given the burden of medical treatment costs placed on ESRD patients with diabetes, more aggressive interventions should be implemented to prevent diabetes and renal complications among patients with diabetes.

Citations

Citations to this article as recorded by  
  • Health-Related Quality of Life Based on Comorbidities Among Patients with End-Stage Renal Disease
    Jieun Cha, Dallong Han
    Osong Public Health and Research Perspectives.2020; 11(4): 194.     CrossRef
  • Effects for Comorbidities of Chronic Kidney Disease on the Progression to End-stage Renal Disease
    Hwa Jeong Seo
    Journal of Health Informatics and Statistics.2020; 45(4): 356.     CrossRef
  • The Impact of Physical, Psychological, Social Factors on Illness Burden of Long-term Hemodialysis Patients in South Korea
    Jieun Cha
    Journal of Health Informatics and Statistics.2018; 43(3): 159.     CrossRef
  • Effect of diabetic case management intervention on health service utilization in Korea
    Soon Ae Shin, Hyeongsu Kim, Kunsei Lee, Vivian Lin, George Liu
    International Journal of Nursing Practice.2015; 21(6): 780.     CrossRef
  • The Quality of Medical Care Provided to Homeless Diabetes Patients in a General Hospital in Seoul, and the Prevalence of Diabetes Comorbidities
    Sun Hee Beom, Moo Kyung Oh, Chul Woo Ahn
    Korean Journal of Medicine.2014; 86(5): 585.     CrossRef
  • Diabetes Epidemics in Korea: Reappraise Nationwide Survey of Diabetes "Diabetes in Korea 2007"
    Ie Byung Park, Jaiyong Kim, Dae Jung Kim, Choon Hee Chung, Jee-Young Oh, Seok Won Park, Juneyoung Lee, Kyung Mook Choi, Kyung Wan Min, Jeong Hyun Park, Hyun Shik Son, Chul Woo Ahn, Hwayoung Kim, Sunhee Lee, Im Bong Lee, Injeoung Choi, Sei Hyun Baik
    Diabetes & Metabolism Journal.2013; 37(4): 233.     CrossRef
  • Posttransplant Diabetes Mellitus
    Hye Soo Kim, Suk Young Kim
    Korean Journal of Transplantation.2009; 23(2): 123.     CrossRef
Current Status of Aspirin User in Korean Diabetic Patients Using Korean Health Insurance Database.
Ie Byung Park, Dae Jung Kim, Jaiyong Kim, Hyeyoung Kim, Hwayoung Kim, Kyung Wan Min, Seok Won Park, Jeong Hyun Park, Sei Hyun Baik, Hyun Shik Son, Chul Woo Ahn, Jee Young Oh, Sunhee Lee, Juneyoung Lee, Choon Hee Chung, Injeoung Choi, Kyung Mook Choi
Korean Diabetes J. 2006;30(5):363-371.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.363
  • 2,531 View
  • 24 Download
  • 7 Crossref
AbstractAbstract PDF
AIMS: ADA guidelines recommend aspirin for all patients with diabetes who have had a prior CHD events as well as a primary prevention strategy among those with at least one other risk factor. We examined the current status of regular aspirin intake among Korean adults who diagnosed as diabetes. METHODS: This study examined the characteristics of aspirin user in new-onset diabetes over 40 years based on health insurance claims submitted to the Health Insurance Review Agency (HIRA) of Korea during the period from January 2001 through December 2003. New onset diabetes defined as the first health insurance claim of antidiabetic drugs submitted to HIRA for the three months (January to March 2001) that never submitted for previous 6 years. RESULTS: The number of total new-onset diabetic patients was 30,014 in 2001, 29,819 in 2002, and 32,061 in 2003. The incidence rate of diabetes over 40 years for 3 months in 2001, 2002 and 2003 were 0.172%, 0.167% and 0.18. Mean age of women who diagnosed diabetes were significant higher than that of men in 2001 (women 59.2+/-10.6 yrs, men 54.8+/-9.8 yrs), in 2002 (women 59.5+/-10.6 yrs, men 54.6+/-9.3 yrs) and in 2003 (women 59.6+/-10.7 yrs, men 54.7+/-9.9 yrs) (p < 0.001). The number of aspirin user increased from 2,065 (6.9%) in 2001, 2,638 (8.9%) in 2002 and 3,711 (11.6%) in 2003. 30.5% of new-onset diabetics in 2001 had hypertension, 12.4% of them had hypercholesterolemia, 11.8% of them had cerebral infarct, 2.6% of them had cerebral hemorrhage, 3.8% of them had coronary heart disease and, but, 55.6% of them had not any CVD. Logistic regression analysis using aspirin use as a dependent variable showed that the number of aspirin use in patients with hypertension, hypercholesterolemia, cerebral infarct and coronary heart disease was higher than in patients without those (hypertension [OR], 3.89 (95% CI, 3.52~4.31); hypercholesterolemia [OR], 2.16 (95% CI, 1.90~2.46; cerebral infarct [OR], 2.05 (95% CI, 1.82~2.30); coronary heart disease [OR], 9.41 (95% CI, 8.20~10.80), respectively). Coronary heart disease was the most important associated factor of aspirin use. CONCLUSIONS: We found significant underuse of aspirin therapy among our population compared with that of America. Major efforts are needed to increase aspirin use in diabetic patients.

Citations

Citations to this article as recorded by  
  • Evaluation of low-dose aspirin for primary prevention of ischemic stroke among patients with diabetes: a retrospective cohort study
    Ye-Jee Kim, Nam-Kyong Choi, Mi-Sook Kim, Joongyub Lee, Yoosoo Chang, Jong-Mi Seong, Sun-Young Jung, Ju-Young Shin, Ji-Eun Park, Byung-Joo Park
    Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef
  • Current Status of Prescription in Type 2 Diabetic Patients from General Hospitals in Busan
    Ji Hye Suk, Chang Won Lee, Sung Pyo Son, Min Cheol Kim, Jun Hyeob Ahn, Kwang Jae Lee, Ja Young Park, Sun Hye Shin, Min Jeong Kwon, Sang Soo Kim, Bo Hyun Kim, Soon Hee Lee, Jeong Hyun Park, In Joo Kim
    Diabetes & Metabolism Journal.2014; 38(3): 230.     CrossRef
  • Epidural Hematoma Related with Low-Dose Aspirin : Complete Recovery without Surgical Treatment
    Kyoung-Tae Kim, Dae-Chul Cho, Suk-Won Ahn, Suk-Hyung Kang
    Journal of Korean Neurosurgical Society.2012; 51(5): 308.     CrossRef
  • The Prevalence and Features of Korean Gout Patients Using the National Health Insurance Corporation Database
    Chan Hee Lee, Na Young Sung
    Journal of Rheumatic Diseases.2011; 18(2): 94.     CrossRef
  • Overlapping Medication Associated with Healthcare Switching among Korean Elderly Diabetic Patients
    Ju-Young Shin, Nam-Kyong Choi, Sun-Young Jung, Ye-Jee Kim, Jong-Mi Seong, Byung-Joo Park
    Journal of Korean Medical Science.2011; 26(11): 1461.     CrossRef
  • Cause-of-Death Trends for Diabetes Mellitus over 10 Years
    Su Kyung Park, Mi-Kyoung Park, Ji Hye Suk, Mi Kyung Kim, Yong Ki Kim, In Ju Kim, Yang Ho Kang, Kwang Jae Lee, Hyun Seung Lee, Chang Won Lee, Bo Hyun Kim, Kyung Il Lee, Mi Kyoung Kim, Duk Kyu Kim
    Korean Diabetes Journal.2009; 33(1): 65.     CrossRef
  • The Current Status of Type 2 Diabetes Management at a University Hospital
    Young Sil Lee
    Korean Diabetes Journal.2009; 33(3): 241.     CrossRef
Current Status of Diabetic Foot in Korean Patients Using National Health Insurance Database.
Choon Hee Chung, Dae Jung Kim, Jaiyong Kim, Hyeyoung Kim, Hwayoung Kim, Kyung Wan Min, Seok Won Park, Jeong Hyun Park, Sei Hyun Baik, Hyun Shik Son, Chul Woo Ahn, Jee Young Oh, Sunhee Lee, Juneyoung Lee, Kyung Mook Choi, Injeoung Choi, Ie Byung Park
Korean Diabetes J. 2006;30(5):372-376.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.372
  • 2,880 View
  • 41 Download
  • 18 Crossref
AbstractAbstract PDF
BACKGROUND
Foot ulcer diseases are more prevalent in diabetic patients than that those of non-diabetic patients. Several reports showed the risk of amputation and the medical cost were increased when foot ulcer developed. Therefore, strict glycemic control from the initial period of diabetes is necessary. Since there is no enough epidemiologic data, large scaled studies for medical and economic consequences about diabetic foot ulcer are needed. METHODS: This study was based on health insurance claims submitted to the National Health Insurance Review Agency during the period from December 1994 through December 2002. We investigated the incidence and medical cost of foot disorders in Korean population using the disease-classification codes on the health insurance claim forms. RESULTS: The incidences of foot disorders (per 100,000 of population) were 49.7 for amputations, 99.7 for ulcers, and 1,051 for injuries in diabetic patients, and 4.2 for amputations, 10.3 for ulcers, and 943 for injuries in non-diabetic patients. Relative risk of the incidences of foot amputation, ulcer, and injury in diabetic patients comparing with non-diabetic patients were 11.7, 9.7, and 1.1, respectively. Total medical costs (per capita) of foot amputation, ulcer, and injury in diabetic patients were 2.0, 1.7, and 2.1 times higher, respectively, than those of non-diabetic patients. Mean hospital stay of foot amputation, ulcer, and injury in diabetic patients were 1.6, 1.3, and 1.7 times more, respectively, than those of non-diabetic patients. CONCLUSION: In diabetic patients, the incidences of foot amputation and ulcer are higher than those of non-diabetic patients. To reduce those incidences, we need to early strict glycemic control as well as government based management.

Citations

Citations to this article as recorded by  
  • The Risk of the Aggravation of Diabetic Foot According to Air Quality Factors in the Republic of Korea: A Nationwide Population-Based Study
    Saintpee Kim, Sungho Won, Young Yi
    International Journal of Environmental Research and Public Health.2024; 21(6): 775.     CrossRef
  • Efficacy of a povidone‐iodine foam dressing (Betafoam) on diabetic foot ulcer
    Heui C. Gwak, Seung H. Han, Jinwoo Lee, Sejin Park, Ki‐Sun Sung, Hak‐Jun Kim, Dongil Chun, Kyungmin Lee, Jae‐Hoon Ahn, Kyunghee Kwak, Hyung‐Jin Chung
    International Wound Journal.2020; 17(1): 91.     CrossRef
  • Regional Variation in the Incidence of Diabetes-Related Lower Limb Amputations and Its Relationship with the Regional Factors
    Sung Hun Won, Jahyung Kim, Dong-Il Chun, Young Yi, Suyeon Park, Kwang-Young Jung, Gun-Hyun Park, Jaeho Cho
    Journal of Korean Foot and Ankle Society.2019; 23(3): 121.     CrossRef
  • Depth and combined infection is important predictor of lower extremity amputations in hospitalized diabetic foot ulcer patients
    Eun-Gyo Jeong, Sung Shim Cho, Sang-Hoon Lee, Kang-Min Lee, Seo-Kyung Woo, Yoongoo Kang, Jae-Seung Yun, Seon-Ah Cha, Yoon-Jung Kim, Yu-Bae Ahn, Seung-Hyun Ko, Jung-Min Lee
    The Korean Journal of Internal Medicine.2018; 33(5): 952.     CrossRef
  • Risk factors for diabetic foot ulcer recurrence: A prospective 2-year follow-up study in Egypt
    Walaa A. Khalifa
    The Foot.2018; 35: 11.     CrossRef
  • Microbiology and Antimicrobial Therapy for Diabetic Foot Infections
    Ki Tae Kwon, David G. Armstrong
    Infection & Chemotherapy.2018; 50(1): 11.     CrossRef
  • Diagnosis and Management of Diabetic Foot
    Chang Won Lee
    The Journal of Korean Diabetes.2018; 19(3): 168.     CrossRef
  • Effects of foot complications in patients with Type 2 diabetes mellitus on public healthcare: An analysis based on the Korea National Diabetes Program Cohort
    So Young Park, Sang Youl Rhee, Suk Chon, Kyu Jeung Ahn, Sung-Hoon Kim, Sei Hyun Baik, Yongsoo Park, Moon Suk Nam, Kwan Woo Lee, Jeong-taek Woo, Ki Hong Chun, Young Seol Kim
    Journal of Diabetes and its Complications.2017; 31(2): 375.     CrossRef
  • Prevalence and Current Status of Treatment of Diabetic Foot in South Korea
    Jae-Ik Bae, Je Hwan Won, Jun Su Kim, Man Deuk Kim, Chang Jin Yoon, Yun Ku Cho
    Journal of the Korean Society of Radiology.2016; 74(3): 169.     CrossRef
  • Lifestyle, Diet, Self-care, and Diabetes Fatalism of Diabetic Patients with and without Diabetic Foot
    Jungha Choi, Juhee Kang, Hongmie Lee
    Korean Journal of Community Nutrition.2014; 19(3): 241.     CrossRef
  • The Quality of Medical Care Provided to Homeless Diabetes Patients in a General Hospital in Seoul, and the Prevalence of Diabetes Comorbidities
    Sun Hee Beom, Moo Kyung Oh, Chul Woo Ahn
    Korean Journal of Medicine.2014; 86(5): 585.     CrossRef
  • Advanced Glycation End Products and Management of Diabetes Diet
    Hyun-Sun Lee
    The Journal of Korean Diabetes.2013; 14(2): 90.     CrossRef
  • Cost-effectiveness Analysis of Home Care Services for Patients with Diabetic Foot
    Chong Rye Song, Yong Soon Kim, Jin Hyun Kim
    Journal of Korean Academy of Nursing Administration.2013; 19(4): 437.     CrossRef
  • Diabetes Epidemics in Korea: Reappraise Nationwide Survey of Diabetes "Diabetes in Korea 2007"
    Ie Byung Park, Jaiyong Kim, Dae Jung Kim, Choon Hee Chung, Jee-Young Oh, Seok Won Park, Juneyoung Lee, Kyung Mook Choi, Kyung Wan Min, Jeong Hyun Park, Hyun Shik Son, Chul Woo Ahn, Hwayoung Kim, Sunhee Lee, Im Bong Lee, Injeoung Choi, Sei Hyun Baik
    Diabetes & Metabolism Journal.2013; 37(4): 233.     CrossRef
  • Treatment of Diabetic Foot Ulcer Using Matriderm In Comparison with a Skin Graft
    Hyojin Jeon, Junhyung Kim, Hyeonjung Yeo, Hoijoon Jeong, Daegu Son, Kihwan Han
    Archives of Plastic Surgery.2013; 40(04): 403.     CrossRef
  • Three Cases of Auricular Pressure Ulcer in Ambulatory Leprotic Patients
    Nam Soo Han, Hyung-Cheol Park
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2013; 56(9): 588.     CrossRef
  • Diabetic Foot: Past and Present
    Ji Ho Lee, Choon Hee Chung
    Journal of Korean Diabetes.2011; 12(2): 69.     CrossRef
  • Epidemiology of Diabetic Foot Disease
    Kyu Jeung Ahn
    Journal of Korean Diabetes.2011; 12(2): 72.     CrossRef
Current Status of the Continuity of Ambulatory Diabetes Care and its Impact on Health Outcomes and Medical Cost in Korea Using National Health Insurance Database.
Jaiyong Kim, Hyeyoung Kim, Hwayoung Kim, Kyung Wan Min, Seok Won Park, Ie Byung Park, Jeong Hyun Park, Sei Hyun Baik, Hyun Shik Son, Chul Woo Ahn, Jee Young Oh, Sunhee Lee, Juneyoung Lee, Choon Hee Chung, Kyung Mook Choi, Injeoung Choi, Dae Jung Kim
Korean Diabetes J. 2006;30(5):377-387.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.377
  • 2,540 View
  • 36 Download
  • 21 Crossref
AbstractAbstract PDF
BACKGROUND
The continuity of care in chronic diseases, especially in diabetes, was emphasized from many studies. But large scale studies with long-term observation which confirm the impact of continuity of care on health outcomes are rare. This study tried national level 3 year observation to find differences in hospitalization, mortality and medical costs among patient groups with different utilization pattern. METHODS: The 1,088,564 patients with diabetes diagnosis and diabetes drug prescription in 2002, from 20 to 79 years old, and survived until the end of 2004 were included. Annual drug prescription days, number of visited clinics and quarterly continuity of care were measured. Gender, age group, living area, health insurance premium level (as a proxy of the income level), years of first DM diagnosis, five co-morbidities (hypertension, heart disease, stroke, renal disease, admission with DM), hospitalization experience and the type of main attending clinic were adjusted. Hospitalization, mortality and high costs group (top quintile) in 2005 were predicted by multiple logistic regression model. RESULTS: Patients who failed in continuity of care in 2003 and 2004 showed higher hospitalization (OR =1.29), higher mortality (OR =1.75) and they are more likely to be high costs group (OR =1.34) in 2005 than who fulfilled the continuity of care. Patients who have single attending clinic also showed lower hospitalization, lower mortality and lower cost. Completeness in diabetic drug prescription were correlated with lower hospitalization, lower mortality but with higher cost. Possible cost saving from continual care with single attending clinic was estimated at Won 417 billion (Dollar 1 = Won 943.7). Possible expenditure from complete drug prescription was Won 228 billion. So, net saving was Won 139 billion in our study population. CONCLUSION: Continual care and single attending clinic saves patient's life and national costs. Fragmented primary care system in Korea should be reformed for more effective care of chronic diseases. National Health Insurance Database in Korea enables nationwide long-term observation study which overcomes the many limitations found in hospital-based studies and cross-sectional surveys.

Citations

Citations to this article as recorded by  
  • The effect of continuity of care on medical costs in patients with chronic shoulder pain
    Ju-hyun Oh, Boyoung Jung, Eun-San Kim, Namkwen Kim, In-Hyuk Ha
    Scientific Reports.2021;[Epub]     CrossRef
  • Effect of Practicing Health Behaviors on Unmet Needs among Patients with Chronic Diseases: A Longitudinal Study
    Bich-Na Jang, Hwi-Jun Kim, Bo-Ram Kim, Seonyeong Woo, Woo-Jin Lee, Eun-Cheol Park
    International Journal of Environmental Research and Public Health.2021; 18(15): 7977.     CrossRef
  • Impact of Continuous Care on Health Outcomes and Cost for Type 2 Diabetes Mellitus: Analysis Using National Health Insurance Cohort Database
    Ji Hyun Nam, Changwoo Lee, Nayoung Kim, Keun Young Park, Jeonghoon Ha, Jaemoon Yun, Dong Wook Shin, Euichul Shin
    Diabetes & Metabolism Journal.2019; 43(6): 776.     CrossRef
  • Chasms in Achievement of Recommended Diabetes Care among Geographic Regions in Korea
    Sanghyun Cho, Ji-Yeon Shin, Hyun Joo Kim, Sang Jun Eun, Sungchan Kang, Won Mo Jang, Hyemin Jung, Yoon Kim, Jin Yong Lee
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Evaluation of the chronic disease management program for appropriateness of medication adherence and persistence in hypertension and type-2 diabetes patients in Korea
    Jung-Ae Kim, Eun-Sook Kim, Eui-Kyung Lee
    Medicine.2017; 96(14): e6577.     CrossRef
  • Greater continuity of care reduces hospital admissions in patients with hypertension: An analysis of nationwide health insurance data in Korea, 2011–2013
    Young Soon Nam, Kyoung Hee Cho, Hee-Chung Kang, Kwang-Sig Lee, Eun-Cheol Park
    Health Policy.2016; 120(6): 604.     CrossRef
  • Impact of Market Competition on Continuity of Care and Hospital Admissions for Asthmatic Children: A Longitudinal Analysis of Nationwide Health Insurance Data 2009-2013
    Kyoung Hee Cho, Eun-Cheol Park, Young Soon Nam, Seon-Heui Lee, Chung Mo Nam, Sang Gyu Lee, Saravana Kumar
    PLOS ONE.2016; 11(3): e0150926.     CrossRef
  • Factors affecting treatment compliance in new hypertensive patients in Korea
    Hyun-Jin Kim, Kanghee Moon, Tae-hee Park, So-Youn Park, Seok-Jun Yoon, In-Hwan Oh
    Clinical and Experimental Hypertension.2016; 38(8): 701.     CrossRef
  • The relationship between diabetes and the reoperation rate after lumbar spinal surgery: a nationwide cohort study
    Chi Heon Kim, Chun Kee Chung, Sukyoun Shin, Bo Ram Choi, Min Jung Kim, Byung Joo Park, Yunhee Choi
    The Spine Journal.2015; 15(5): 866.     CrossRef
  • The Association between Continuity of Care and All-Cause Mortality in Patients with Newly Diagnosed Obstructive Pulmonary Disease: A Population-Based Retrospective Cohort Study, 2005-2012
    Kyoung Hee Cho, Young Sam Kim, Chung Mo Nam, Tae Hyun Kim, Sun Jung Kim, Kyu-Tae Han, Eun-Cheol Park, Hemachandra Reddy
    PLOS ONE.2015; 10(11): e0141465.     CrossRef
  • Associations Between the Continuity of Ambulatory Care of Adult Diabetes Patients in Korea and the Incidence of Macrovascular Complications
    Young-Hoon Gong, Seok-Jun Yoon, Hyeyoung Seo, Dongwoo Kim
    Journal of Preventive Medicine and Public Health.2015; 48(4): 188.     CrossRef
  • Evaluation of low-dose aspirin for primary prevention of ischemic stroke among patients with diabetes: a retrospective cohort study
    Ye-Jee Kim, Nam-Kyong Choi, Mi-Sook Kim, Joongyub Lee, Yoosoo Chang, Jong-Mi Seong, Sun-Young Jung, Ju-Young Shin, Ji-Eun Park, Byung-Joo Park
    Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef
  • Factors Affecting Diabetic Screening Behavior of Korean Adults: A Multilevel Analysis
    Hyeongsu Kim, Minjung Lee, Haejoon Kim, Kunsei Lee, Sounghoon Chang, Vitna Kim, Jun Pyo Myong, Soyoun Jeon
    Asian Nursing Research.2013; 7(2): 67.     CrossRef
  • Higher quality primary care is associated with good self-rated health status
    N. J. Sung, J. F. Markuns, K. H. Park, K. Kim, H. Lee, J. H. Lee
    Family Practice.2013; 30(5): 568.     CrossRef
  • Diabetes Epidemics in Korea: Reappraise Nationwide Survey of Diabetes "Diabetes in Korea 2007"
    Ie Byung Park, Jaiyong Kim, Dae Jung Kim, Choon Hee Chung, Jee-Young Oh, Seok Won Park, Juneyoung Lee, Kyung Mook Choi, Kyung Wan Min, Jeong Hyun Park, Hyun Shik Son, Chul Woo Ahn, Hwayoung Kim, Sunhee Lee, Im Bong Lee, Injeoung Choi, Sei Hyun Baik
    Diabetes & Metabolism Journal.2013; 37(4): 233.     CrossRef
  • Continuity of ambulatory care and health outcomes in adult patients with type 2 diabetes in Korea
    Jae-Seok Hong, Hee-Chung Kang
    Health Policy.2013; 109(2): 158.     CrossRef
  • Strategies for improvement of primary care in Korea
    Heui Sug Jo
    Journal of the Korean Medical Association.2012; 55(10): 959.     CrossRef
  • Factors associated with diabetes outpatient use of tertiary or general hospitals as their usual source of care in Korea
    Jung Chan Lee, Kye Hyun Kim, Han Nah Kim, Nam Soon Kim
    Journal of the Korean Medical Association.2012; 55(12): 1215.     CrossRef
  • Factors associated with the hypertension outpatients' choice of healthcare providers in Korea
    Jung Chan Lee, Kye Hyun Kim, Han Nah Kim, Yoon Hyung Park
    Journal of the Korean Medical Association.2011; 54(9): 961.     CrossRef
  • Analysis of the Continuity of Outpatient among Adult Patients with hypertension and its Influential Factors in Korea
    Kyung-Ae Son, Yoon-Shin Kim, Min-Hee Hong, Mi-As Jeong
    Journal of the Korea Academia-Industrial cooperation Society.2010; 11(6): 2161.     CrossRef
  • Continuity of Care for Elderly Patients with Diabetes Mellitus, Hypertension, Asthma, and Chronic Obstructive Pulmonary Disease in Korea
    Jae Seok Hong, Hee Chung Kang, Jaiyong Kim
    Journal of Korean Medical Science.2010; 25(9): 1259.     CrossRef
Randomized Controlled Trial
Titration with an Initially Lower Dose Increased Compliance of Cilostazol (Pletaal(R)) in Diabetic Patients.
Hyo Jeong Kim, Kyung Ah Han, Hyun Jin Kim, Kang Seo Park, Eung Jin Kim, Kyung Wan Min
Korean Diabetes J. 2006;30(5):388-397.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.388
  • 2,223 View
  • 28 Download
AbstractAbstract PDF
BACKGROUND
Headache is frequently reported by patients using cilostazol, which is a potent inhibitor of platelet aggregation with vasodilatory effects, for preventing atherosclerotic disease. The aims of this study were to think out a dosing schedule for improving compliance on headache and to investigate the possible mechanisms of headache associated with atherosclerosis measured as carotid intimal-media thickness (IMT) in Korean diabetic patients. METHODS: We therefore randomized patients into three groups according to the different dosing regimens for 6 weeks (1) group 1; 50 mg once daily, followed by 50 mg twice daily, and then 100 mg twice daily or (2) group 2; 50 mg twice daily, followed by 100 mg twice daily or (3) group 3; 100 mg twice daily without titration. We evaluated severity of the headache by visual analog scaled (VAS) symptom score from zero to ten and measured carotid IMT using high resolution ultrasound. RESULTS: A total of 122 diabetic patients were analyzed. The mean values of age, sex, duration of diabetes, BMI, HbA1c, lipid profiles, blood pressure, and smoking were not different among three groups. The proportion of headache was significantly lower in group 1 than group 2 and 3 (26% vs. 48% and 51%, P < 0.05). The proportion of severe headache was significantly lower in group 1 than group 2 and 3 (3% vs. 19% , 27%, P < 0.05). Among patients who had headache, the proportion of severe headache was significantly lower in group 1 than group 3. (10% vs. 52%, P < 0.05). The VAS symptom score of headache was significantly lower in group 1 than group 3 (4.9+/-2.1 vs. 7.0+/-2.4, P < 0.05). The proportion of the discontinuation of medication due to headache was significantly lower in group 1 than other two groups (8% vs. 24% and 29%, P < 0.05). The patients who had discontinued medication due to headache had lower carotid IMT than in whom were tolerable (Mean carotid IMT; 0.65+/-0.12 vs. 0.77+/-0.16 mm, P < 0.01, Maximal carotid IMT; 0.80+/-0.17 vs. 0.94+/-0.23 mm, P < 0.01). The proportion of patients who had discontinued medication due to headache was significantly lower in group 1 than other two groups (8% vs. 24%, 29%, P < 0.05] CONCLUSION: Titration with an initially lower dose of cilostazol could be considered to reduce the proportion and severity of headache and thereby increase compliance. Atherosclerosis estimated as carotid IMT may contribute to the tolerability of cilostazol.
Case Reports
Clinical Courses of Two Women with Gestational Diabetes Mellitus Who are GAD Antibody Positive.
Sung Hoon Yu, Min Jun Song, Sung Hoon Kim, Chang Hoon Yim, Ki Ok Han, Won Kun Park, Hyun Koo Yoon, Ho Yeon Chung
Korean Diabetes J. 2006;30(5):398-402.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.398
  • 2,246 View
  • 19 Download
AbstractAbstract PDF
Gestational diabetes mellitus (GDM) is defined as glucose intolerance of various degrees with onset or first recognition during pregnancy. Women with GDM are at high risk of developing type 2 diabetes later in life, but the risk of developing type 1 diabetes is also increased. Positivity for glutamic acid decarboxylase (GAD) antibodies during pregnancy confers a high risk for subsequent progression to type 1 diabetes. Here, we reported the two cases with GDM who were GAD antibody positive and progressed to type 1 diabetes with different time-courses. One woman with GDM progressed rapidly to classical type 1 diabetes while the other became slowly progressive IDDM (SPIDDM) [or latent autoimmune diabetes in adults (LADA)].
A Case of Vancomycin-induced Pancytopenia in the Diabetic Patient with Infected Foot Ulcer.
Heung Yong Jin, Su Jin Jung, Ji Hyun Park, Tae Sun Park, Hong Sun Back
Korean Diabetes J. 2006;30(5):403-407.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.403
  • 1,967 View
  • 21 Download
AbstractAbstract PDF
Diabetic foot ulcer is a common complication in diabetic patients and the outcome of foot ulcer depends on the severity of ulcer and combined infection such as osteomyelitis. So antibiotics targeting Gram positive cocci including Staphylococcus aureus have been used frequently. However, during the antibiotic therapy, diverse adverse reactions could be happened including red man syndrome, chest pain, hypotension, thrombocytopenia, neutropenia and drug eruption. Among these reactions, hematologic adverse events such as pancytopenia are rare and it could be lethal if happened. This article reports a case of pancytopenia associated with vancomycin in treating the diabetic patient with infected foot ulcer.

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer