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Volume 10(2); 1986
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Muse capillary Basement Membrane Thickness in the patient with Diabetic Proliferative Retinopathy
Tai Hee Lee , Min Young Chung , Pil Woo Chung , Ho Jung Ryu , Young Ho Jang
Korean Diabetes J. 1986;10(2):127-130.
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Effect of Naloxone on Counter Insulin Hormone Secretion in Insulin - induced Hypoglycemia
Yeong Shil Ju , Sung Woon Kim , In Myung Yang , Jin Woo Kim , Young Seol Kim , Young Kil Choi
Korean Diabetes J. 1986;10(2):131-138.
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In Vitro Effects of Sulfonylurea on Insulin Secretion from Isolated Pancreatic Islets and Insulin Action in Isolated Adipocytes of Rat
Bong Yun Cha , Ho Young Son , Kwang Woo Lee , Young Woo Kim , Sung Ku Kang , Kwan Su Hong , Byung Kee Bang
Korean Diabetes J. 1986;10(2):139-150.
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Evaluation of Osteopenia in Non Insulin - Dependent Diabetes by Scanning Densitometer
Hak Rhim Choi , Hyun Koo Yoon , In Myung Yang , Young Seol Kim , Jin Woo Kim , Kwang Won Kim , Young Kil Choi
Korean Diabetes J. 1986;10(2):151-159.
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It is now well established that the proinsulin connecting peptide(C-peptide) is released into blood from the beta cells together with insuline. Assay of serum C-peptide, as a substitute for the insulin assay, provides an additional means to evaluate the endocrine function of the pancreatic beta cells even in the presence of circulating insulim antibody. The measurement of plasma C-peptide could not provide a accurate reflection of various physiologic conditions. But,because of the relatively high urinary clearance of C-peptide and the absence of signficant herpatic uptake, urinary C-peptide measurement might provide a accurate reflection of B-cell secretory activity during 24 hours. We measured 24 hours urine C-peptide excretion in the normal control, NIDDM, inflection diseas, insulinoma, hemochromatosis and the chronic renal failure. The results were as folIows: 1. In the normal Korean, the 24 hours urine C-peptide was 52 +-18 pg/gm creatinine. 2. In patients with NIDDM, the urine C-peptide was not different from that of normal subjects(53+- 14 pg/gm cr). 3. The urine C-peptide was markedly increased in response to infection, although the urine C-peptide response to infection in patients with NIDDM(124+- 38 pg/gm cr) was significantIy lees than the non-diabetic patients(155+- 58 pg/gm cr ), 4. The urine C-peptide was decreased in the patient with hemochromatosis(44 pg/gm cr) but markedly increased in the patient with insulinoma (132 pg/gm cr) 5. In patients with chronic renaI failure, the urine C-peptide was decreased(2.3+-1.1pg/gm cr)
A Study on the Assay of Insulin Degradation priducts in Human Erythrocyte
Won Kun Park , In Kwon Han , Sun Woo Kim
Korean Diabetes J. 1986;10(2):161-172.
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After an intravenous gIucose load, a series of serum glucose, insulin and C-peptide concentration were measured in 12 non insulin dependent diabetes meilitus and 10 age and sex matched normal control subjeets. Clucose disappearance rate, integrated insulin and C-peptide concentration, insulinogenic index, molar ratio of C-peptide and insulin and hepatic clearance rate of insulin were caIculated and compared. Followings were the results; 1.The fasting ccincentration of insuIin and C-peptide were 4.17+-0.75 pm/ml and 0.93+-0.07 ng/ml in control subjects,and 12.50+-1,85 pg/ml and 1.63+- 0.19 ng/Mi in diabetic respectively. Both fasting concentration of insulin and C-peptide were significantly higher in diabetics than in control subjects(p<0. 025) Five minutes after glucose load, the maximal insulin concentration in control subjets was 64.37+-12.17 pu/ml and it had increaed 15.4 times in comparing with fasting stage. But there was no acute response in diabetics. Sixty rninutes after glucose load, the concentration of insulin and C-peptide were 10.39+-1.46 pu/ml and 2.59+- 0. 02 ng/ml in control subjects, and 21. 55+-2.35 pu/ml and 3.36+-0.42 ng/ml in diabetics respectively, showing increased secretion of insulin and C-peptide in later stage of diabetics. 2.The glucose disappearance rates were 3. 35 +-0.51%/min in control subjects and 1.83+-0.16%/min, in diabetics, showing significantly lower value in diabetics(p<0.05) 3.Integrated insulin and C-peptide concentration of the first 10 minutes for acute response were 1.88+-0.35 ng/ml and 3.10 +-2.47 ng/ml in control subjects, and 0.58+-0.07 ng/ml and 2.04+-0.22 ng/ml in diabetics(p<0.05) But those of the 60 miniutes for total response were 1.00+- 0.15 ng/ml and 2.95+-0.29 ng/ml in control subjects, and 0.80 +-0.12ng/ml and 2.55+-0.32ng/ml in diabetics respectively,which were slightly lower than control subjects, but without significant statistical difference. 4. The insulinogenic index during 0~5min, and 0~ l0 min, period for aqutel response and 0~60min, period for total response were as follows; 0.186+- 0.234, 0.221+- 0.004 and 0.156+-0.039 in control subjects, and 0.005+-0.010, 0.003+-0.001 and 0.047+-0.025 in diabetics respectively (p<0.001) The correlation coefficient between insulinogeic index and integrated insulin concentration was 0,54(p<0.001) in control subjects and 0. 18(p< 0.001) in diabetics during 10 minutes and 0.80(p<0.001) in control subjects and 0.88(p<0.001) in diabetics during 60 minutes. There were significant correlation between the two indices except in diabetics during 10 minutes. 5. The molar ratio of C-peptide and insulin at fasting stage was 12. 56 +-0. 33, 3.27+- 0. 21 at 5 min. 5.47+- 0.84 at 10 min. and 10.86+-1.2 at 60 rnin. In control subjects, and in diabetics 7.03+- 0.96, 7.49+- 1.87, 10. 94+-2.85 and 6.18+-1,55 respectively. 6. The hepatic clearance rate of insulin was calculated and results were as folows: 55.1+- 2.7% in control subjects and 55.5+-4.6% in diabetics, showing no stastical ditference. But the correlation coeffieient between secretion rate and hepatic clearance rate of insulin was 0.72(p<0.5) in control subjects and 0.29(p<0.4) in diabetics, showing slightly negative correlation between the two in control subjects. 7. The correlation coefficient between fasting blood gIucose concentration and intergrated concentration of first 10 minutes for both group was 0.58%(p<0.025) ,showing negative correlation. This correlation was more accentuated by using natural logarithmic scale in integrated concentration. 8.There was significiant positive correlation btween integrated insuln conceritration of first 10 minutes and glucose disappearance rate with the correlation coefficient of 0.04 (p<0.01). From these dats, it was concluded that non insulin depenent diabetics were characterized mot only by increased fasting blood glucose, lowered glucose disapearance rate and insulinogenic index, and almosrt normal to
Mechanism of Glucose Intolerance in Chronic Liver Disease - Role of Glucagon and Free Fatty Acid
Kyu Il Suh , Sung Hee Ihm , Joong Yeol Park , Sang Jun Choi , Hong kyu Lee , Chung Yong Kim , Hun Ki Min
Korean Diabetes J. 1986;10(2):173-179.
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Food Exchange System in Diet Therapy for the Diabetics
O Keum Song , Doo Man Kim , Hyung Joon Yoo , Hong Kyu Lee , Hun Ki Min
Korean Diabetes J. 1986;10(2):181-186.
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To evaluate the clinical significance of HbAC in diabetics, we investigated the relationships between hemoglolbin A,C blood suger, urinie suga, and serum lipid in 70 diabetics. The results are summarized as follows: 1) The mean HbA,C levels in diabetics was significantly higher than that of normal subjects (p<0.001) 2) The HbAC levels in diabetics was not related to the duration of disease and therapy(p>0.05.), 3) ln diabetics, the positive correlations were observed between HbC Ievei and PBS,PP 2hr sugar and 24 hours urine sugar, respectively (r=0.63,0.67,0.59. P<0.001). 4) The HbAC levels was not related to the complication of diabetics, but highger level in diabetic ketoacidosis. 5) The postive correlations were not observed between HbAC levels and blood lipid including triglyceride, cholesterol and beta-lipoprotein(r=0.09,0.11,0.13., p>0.05) This resuIt suggest that HbAC measurement is a simple, rapid and objective procedure to ascess diabetic control and may serve as a screening test for uncontrolIed dliabetics.
A Study of Dictions in Hypoglycemic Symptoms
Young Suk Shim
Korean Diabetes J. 1986;10(2):187-190.
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We complared the educationablity of the present food exchange system and food exchang system using '100 Ca;orie-exchange unit' in 10doctors, 10 dietitians, 10nurses and age, sex matched 12 diabetic patients. 1. Groups which were educated with 100 Calorie-exchange units' system scored higher understanding after education. 2. 100 Calorie-exchange unit' system proved to be simple and easy for the calculation of calories. 3)On three-day-food record the patients group educated by 100 Calorie-exchange unit' system showed more satisfied food consumption profiles, than the group using current food exchange system.
A Study on the Evaluation of Diet - Education program of Diabetes
Yoo Sil Kim , Jung Ja Seung , Doo Man Kim , Sung Bong Kim , Hyung Joon Yoo
Korean Diabetes J. 1986;10(2):191-196.
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We have not yet any dats on the patterns of dibetes reponses to administered insuIin in Korea diabetics. The authors had an opportunity to study on the blood glucose response to singIe injection of intermediate-acting insulin in Korean insulin- requiring diabetice. The results obtained were as followings: 1) WhiIe the majority of patients(74.6% of 123 cases) obtain a satisfactory 24-hour clinical response to a single dose of NPH insnlin(normal pattern), transient pattern was presented in 11.4%, delayed pattern in 10.6%, and brittle pattern in 10.6%. 2. Normal response pattern was more common in female than male and deIayed response pattern was more common over 60 years old. 3)Among the cases with diabetes over 10 years, delayed response pattern was the highest incidenee with 76. 9%.

Diabetes Metab J : Diabetes & Metabolism Journal