Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Review

Page Path
HOME > Article category > Review
297 Review
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Reviews
Diabetes and Osteoporosis.
Ki Won Oh
Korean Diabetes J. 2009;33(3):169-177.   Published online June 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.3.169
  • 1,890 View
  • 21 Download
  • 7 Crossref
AbstractAbstract PDF
Increased life expectancy and increased obesity have contributed to an increasing incidence of osteoporosis and diabetes mellitus. Recent meta-analyses and cohort studies confirm that diabetes is associated with a higher risk of fracture. Patients with type 2 diabetes exhibit increased fracture risks despite a higher bone mass, which are mainly attributable to non-skeletal risk factors. Patients with type 1 diabetes may have impaired bone formation because of absence of the anabolic effects of insulin and insulin-like growth factor I (IGF-I) system. Several clinical studies have reported adverse skeletal actions of peroxisome proliferator-activated receptor gamma (PPARgamma) agonist in humans. Obesity regulates bone metabolism not only by increasing weight loading but also by modulating adipokines that are known to affect bone remodeling.

Citations

Citations to this article as recorded by  
  • Relationship between hs-CRP and HbA1c in Diabetes Mellitus Patients: 2015–2017 Korean National Health and Nutrition Examination Survey
    Yo-Han Seo, Hee-Young Shin
    Chonnam Medical Journal.2021; 57(1): 62.     CrossRef
  • Correlation between Serum Osteocalcin and Hemoglobin A1c in Gwangju General Hospital Patients
    Yo-Han Seo, Hee-Young Shin
    The Korean Journal of Clinical Laboratory Science.2018; 50(3): 313.     CrossRef
  • Bergapten exerts inhibitory effects on diabetes-related osteoporosis via the regulation of the PI3K/AKT, JNK/MAPK and NF-κB signaling pathways in osteoprotegerin knockout mice
    Xue-Ju Li, Zhe Zhu, Si-Lin Han, Zi-Long Zhang
    International Journal of Molecular Medicine.2016; 38(6): 1661.     CrossRef
  • The association of Osteoporosis and Thyroid Hormone in euthyroid adults
    Hyun Yoon, Eun-Jin Ryu
    Journal of the Korea Academia-Industrial cooperation Society.2015; 16(2): 1137.     CrossRef
  • A Study on the Correlation between Menopausal Rating Scale and Bone Mineral Density for Menopausal Osteoporosis Patients
    Kyu In Kwak, Jae Hui Kang, Yun Joo Kim, Hyun Lee
    The Acupuncture.2014; 31(3): 25.     CrossRef
  • Factors Associated with Bone Mineral Density in Korean Postmenopausal Women Aged 50 Years and Above: Using 2008-2010 Korean National Health and Nutrition Examination Survey
    Son-Ok Mun, Jihye Kim, Yoon Jung Yang
    Korean Journal of Community Nutrition.2013; 18(2): 177.     CrossRef
  • Influencing Factors of Bone Mineral Density in Men
    Dong-Ha Lee, Eun-Nam Lee
    Journal of muscle and joint health.2011; 18(1): 5.     CrossRef
Impaired Wound Healing in Diabetes Mellitus.
Min Jeong Kwon, Jeong Hyun Park
Korean Diabetes J. 2009;33(2):83-90.   Published online April 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.2.83
  • 1,744 View
  • 35 Download
  • 3 Crossref
AbstractAbstract PDF
The normal healing of a cutaneous wound is achieved via well-orchestrated integration of complex biological and molecular events of cell migration, proliferation, extracellular matrix deposition and tissue remodeling. Chronic wounds fail to progress through the normal stages of healing, and enter a state of pathologic inflammation. Complicated diabetic patients show delayed wound healing caused by multiple factors including vascular insufficiency, abnormalities of the biochemical environment and hyperglycemia per se. Novel technologies including growth factor therapy, gene therapy, stem cell technologies, synthetic skins and hyperbaric oxygen treatment are under development. In the near future, these therapeutic strategies will be clinically available.

Citations

Citations to this article as recorded by  
  • Promotion of wound healing through low-fluence ablative fractional laser treatment in diabetic mice
    Han Na Lee, Jung Min Bae, Bon Cheol Leo Goo, Young Min Park
    Lasers in Medical Science.2019; 34(2): 421.     CrossRef
  • Ethanol Extracts of Chungkookjang Stimulate the Proliferation and Migration of Human Umbilical Vascular Endothelial Cells
    Jae Sung Hwang, Dae Il Sung, Whan Myung Lee, Young Shin Chung, Han Bok Kim
    The Korean Journal of Microbiology.2014; 50(3): 223.     CrossRef
  • Comparison of Outcome of Trabeculectomy With Mitomycin C and Ahmed Valve Implantation for Uveitic Glaucoma
    Joo Yeon Kim, Hyoung Sub Shim, Hwang Ki Kim, Yong Ho Sohn
    Journal of the Korean Ophthalmological Society.2010; 51(4): 575.     CrossRef
Insulin Resistance During Pregnancy.
Kyu Jeung Ahn
Korean Diabetes J. 2009;33(2):77-82.   Published online April 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.2.77
  • 1,766 View
  • 23 Download
AbstractAbstract PDF
Pregnancy is a complex metabolic state involving dramatic alterations in the hormonal or cytokine environments (increases in estrogen, progesterone, prolactin, cortisol, human chorionic gonadotropin, placental growth hormone and human placental lactogen, TNF-alpha, resistin, leptin, and a decrease in adiponectin) as well as an increasing burden of fuel utilization by the conceptus. Metabolically, the first trimester is characterized by increased insulin sensitivity and lipogenesis. The second and third trimesters, in contrast, are characterized by insulin resistance and increased lipolysis.
Diabetic Cardiomyopathy.
Sung Ai Kim, Jong Won Ha
Korean Diabetes J. 2009;33(1):9-12.   Published online February 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.1.9
  • 2,024 View
  • 20 Download
AbstractAbstract PDF
Cardiovascular disease is the most common cause of death in patients with diabetes mellitus (DM). In particular, the focus of many studies has been on ischemic heart disease, as it is a eading cause of death in diabetic patients. However, independent of coronary artery disease, DM can also lead to cardiac structural and functional changes, supporting the presence of diabetic cardiomyopathy. The pathologic mechanismin the development of diabetic cardiomyopathy is multifactorial including metabolic disturbance, myocardial fibrosis, microvascular disease, and autonomic dysfunction. Functionally, diabetic patients have a higher prevalence of LV (left ventricle) diastolic dysfunction. Because most diabetic patients with early myocardial disease have a wide spectrum of diastolic dysfunction at rest, assessment of LV functional reserve during exercise is helpful for early identification of myocardial dysfunction. Recent research has demonstrated that LV diastolic functional reserve (DFR) assessed by diastolic stress echocardiography was significantly reduced in patients with DM, compared with a control group, suggesting DFR might be an early indicator of diabetic cardiomyopathy. Glycemic control might be the most important and basic therapeutic strategy for preventing the development of diabetic cardiomyopathy. However, more extensive studies are needed to garner further evidence of preventive and therapeutic strategies of diabetic cardiomyopathy.
Double Diabetes.
Sang Youl Rhee, Young Seol Kim
Korean Diabetes J. 2009;33(1):1-8.   Published online February 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.1.1
  • 1,988 View
  • 25 Download
AbstractAbstract PDF
Generally, most cases of diabetes mellitus (DM) are classified as either type 1 DM or type 2 DM based on their pathophysiolgic features. However, it is not always possible to classify this disease clearly according to current diagnostic criteria. Recently, the existence of non-typical diabetes has been found in patients with simultaneous features of both type 1 and type 2 DM. In these patients, obvious evidence of insulin resistance, positivity of islet autoantibody, and progressive beta cell loss are observed concurrently. Moreover, this non-typical diabetes that usually occurs among children and adolescents has been defined as 'double diabetes', and its worldwide incidence has been on the increase as of late. Thus, there has been heightened interest among researchers about this ambiguous condition.
Mitochondrial Dysfunction in Diabetic Cardiomyopathy.
Ji Hyun Ahn, Jae Taek Kim
Korean Diabetes J. 2008;32(6):467-473.   Published online December 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.6.467
  • 2,071 View
  • 30 Download
AbstractAbstract PDF
Metabolic syndrome and diabetes are associated with increased risk of cardiac dysfunction independently of underlying coronary artery disease. The underlying pathogenesis is partially understood but accumulating evidence suggests that alterations of cardiac energy metabolism might contribute to the development of contractile dysfunction. Recent findings suggest that myocardial mitochondrial dysfunction may play an important role in the pathogenesis of cardiac contractile dysfunction in type 2 diabetes. This review is focused on evaluating mechanisms for the mitochondrial abnormalities that may be involved in the development and progression of cardiac dysfunction in diabetes.
Oxidative Stress and Cell Dysfunction in Diabetes: Role of ROS Produced by Mitochondria and NAD(P)H Oxidase.
Sang Soo Kim, Seok Man Son
Korean Diabetes J. 2008;32(5):389-398.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.389
  • 2,088 View
  • 55 Download
  • 10 Crossref
AbstractAbstract PDF
Oxidative stress has been considered to be a major contributor to the pathogenesis of the diabetic macrovascular and microvascular complications. In the absence of an appropriate antioxidant defense mechanism, increased oxidative stress leads to the activation of stress-sensitive intracellular signaling pathways and the formation of gene products that cause damage and contribute to the late complications ofdiabetes. The source of reactive oxygen species (ROS) in the pancreatic beta cells and insulin sensitive cells has postulated to be the mitochondrial electron transport chain. NAD(P)H oxidase-dependent ROS production is also important as the source both in pancreatic beta cells and other cells. NAD(P)H oxidase mediated ROS can alter parameters of signal transduction, insulin secretion, insulin action, cell proliferation and cell death. Additionally, oxidative stress as the pathogenic mechanism linking insulin resistance with dysfunction of both pancreatic beta cells and endothelial cells, eventually leads to diabetes and its complications. Further investigation of the mechanisms and its therapeutic interventions based on focusing NAD(P)H oxidase associated ROS production in the islet cells and other islet cells are needed

Citations

Citations to this article as recorded by  
  • Cytoprotective Effect of Hot-Water Extracts of Protaetia brevitarsis seulensis Larvae in Cisplatin-Treated Macrophages
    Bo-Gyeong Yoo, Jun-Pyo Hong, Ha-Yeon Song, Eui-Hong Byun
    Journal of the Korean Society of Food Science and Nutrition.2022; 51(12): 1252.     CrossRef
  • The Effects of LR and SP Acupuncture on Renal Damage in Streptozotocin-induced Diabetic Mice
    Cho In Lee, Hyun Jong Lee, Yun Kyu Lee, Seong Chul Lim, Jae Soo Kim
    The Acupuncture.2015; 32(3): 41.     CrossRef
  • Effect of Chungkukjang supplementation on oxidative stress and antioxidant nutrients of diabetic rats induced by streptozotocin
    Heyun-Sook Park, Hyun-Joo Kong, Eon-Hee Lee, Eun-Mi Choi, Joung-Hyeon Jang, Myoung-Hee Lee, Ju-Yeon Hong, Su-Jung Hwang, Hyeon-A Jung, Kyung-Mi Yang
    Korean Journal of Food Preservation.2015; 22(2): 281.     CrossRef
  • The Effects of Several Halophytes on Insulin Resistance in Otsuka Long-evans Tokushima Fatty Rats
    Jeong-Yong Cho, Zhangjun Huang, Sun-Young Park, Kyung-Hee Park, Tong-Kun Pai, So-Young Kim, Haeng-Ran Kim, Kyung-Sik Ham
    Korean Journal of Food Science and Technology.2014; 46(1): 100.     CrossRef
  • Protective Effects of Radiation-induced Blackberry Mutant Extract on Carbon Tetrachloride (CCl4)-induced Liver Injury in Sprague-Dawley Rats
    Byoung Ok Cho, Chang-Wook Lee, Yangkang So, Chang-Hyun Jin, Hong-Sun Yook, Myung-Woo Byun, Yong-Wook Jeong, Jong Chun Park, Il-Yun Jeong
    Journal of the Korean Society of Food Science and Nutrition.2014; 43(6): 807.     CrossRef
  • Antioxidant Activities and α-Glucosidase Inhibitory Effect of Water Extracts from Medicinal Plants
    Hyun Sook Kim, Tae Woo Kim, Dae Jung Kim, Jae Sung Lee, Kyoung Kon Kim, Myeon Choe
    Korean Journal of Medicinal Crop Science.2013; 21(3): 197.     CrossRef
  • Antioxidant Effect of Hot water and Ethanol extracts from Cheonnyuncho (Opuntia humifusa) on Reactive Oxygen Species (ROS) Production in 3T3-L1 Adipocytes
    Bo-Ra Yoon, Young-Jun Lee, Sun-Gu Kim, Jung-Young Jang, Hyo-Ku Lee, Seong-Kap Rhee, Hee-Do Hong, Hyeon-Son Choi, Boo-Yong Lee, Ok-Hwan Lee
    Korean Journal of Food Preservation.2012; 19(3): 443.     CrossRef
  • Inhibitory Effects of Panax ginseng C. A. Mayer Treated with High Temperature and High Pressure on Oxidative Stress
    Bo-Ra Yoon, Young-Jun Lee, Hee-Do Hong, Young-Chul Lee, Young-Chan Kim, Young Kyoung Rhee, Kyung-Tack Kim, Ok-Hwan Lee
    The Korean Journal of Food And Nutrition.2012; 25(4): 800.     CrossRef
  • Effect of Dietary Supplementation of β-Carotene on Hepatic Antioxidant Enzyme Activities and Glutathione Concentration in Diabetic Rats
    Jung-Hyun Jang, Kyeung-Soon Lee, Jung-Sook Seo
    Journal of the Korean Society of Food Science and Nutrition.2011; 40(8): 1092.     CrossRef
  • An Association between 609 C →T Polymorphism in NAD(P)H: Quinone Oxidoreductase 1 (NQO1) Gene and Blood Glucose Levels in Korean Population
    Dohee Kim
    Korean Diabetes Journal.2009; 33(1): 24.     CrossRef
Type 2 Diabetes Mellitus and Retinol-Binding Protein 4.
Won Young Lee, Eun Jung Rhee
Korean Diabetes J. 2008;32(4):295-300.   Published online August 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.4.295
  • 2,157 View
  • 28 Download
  • 1 Crossref
AbstractAbstract PDF
New function of retinol-binding protein 4 (RBP4) was identified in addition to the traditional role as a vitamin A transport protein. In the state of insulin resistance even before the onset of type 2 DM, GLUT4 expression by adipocytes is decreased, but those by skeletal muscle is well preserved. Decreased adipocyte GLUT4 causes expression of RBP4 by adipocytes, thus increasing serum RBP4 levels. Increased RBP4 induces insulin resistance on liver and skeletal muscle, thus acting as a diabetogenic signal from adipose tissue. Glucose disposal rate examined by clamp study is inversely related with serum RBP4 levels in humans. In this section, recent works on the metabolism and function of RBP4 were summarized.

Citations

Citations to this article as recorded by  
  • The Effects of Marathon Running on Retinol Binding Protein 4 and C-reactive Protein Levels in Healthy Middle-aged Korean Men
    Jisuk Chae, Sungmin Kim, Junga Lee, Justin Y. Jeon
    The Korean Journal of Obesity.2014; 23(3): 203.     CrossRef
Glucose Toxicity and Pancreatic Beta Cell Dysfunction in Type 2 Diabetes.
Kyu Chang Won, Ji Sung Yoon
Korean Diabetes J. 2008;32(3):175-181.   Published online June 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.3.175
  • 2,324 View
  • 38 Download
  • 4 Crossref
AbstractAbstract PDF
The adverse effects of prolonged exposure of pancreatic islets to supraphysiologic glucose concentrations (i.e. glucose toxicity) is mediated at least in part by glucose oxidation and the subsequent generation of reactive oxygen species (ROS) that can impair insulin gene expression and beta cell function. Multiple biochemical pathways and mechanisms of action for glucose toxicity have been suggested. These include glucose autoxidation, protein kinase C activation, methylglyoxal formation and glycation, hexosamine metabolism, sorbitol formation, and oxidative phosphorylation. There are many potential mechanisms whereby excess glucose metabolites traveling along these pathways might cause beta cell damage. However, all these pathways have in common the formation of reactive oxygen species that, in excess and over time, cause chronic oxidative stress, which in turn causes defective insulin gene expression and insulin secretion as well as increased apoptosis. The intracellular peroxide levels of the pancreatic islets (INS-1 cells, rat islets) by flow cytometry were increased in the high glucose media compared to 5.6 mM glucose media. The insulin, MafA, PDX-1 mRNA levels and glucose stimulated insulin secretion (GSIS) were decreased in high glucose media compared to 5.6 mM glucose media. The HO-1 seems to mediate the protective response of pancreatic islets against the oxidative stress that is due to high glucose conditions. Also, we observed decreased glutathione level, gamma-GCS expression and increased oxidized LDL, malondialdehyde level at leukocytes and mesothelial cells from patients with Korean Type 2 Diabetes (esp, poorly controlled patients). In conclusion, this pathophysiologic sequence sets the scene for considering antioxidant therapy as an adjunct in the management of diabetes, especially type 2 Diabetes.

Citations

Citations to this article as recorded by  
  • Factors That Influence Pancreatic Beta Cell Function and Insulin Resistance in Newly Diagnosed Type 2 Diabetes Patients: A Sub-Analysis of the MARCH Trial
    Yan Duan, Jia Liu, Yuan Xu, Ning Yang, Wenying Yang, Guang Wang
    Diabetes Therapy.2018; 9(2): 743.     CrossRef
  • Effects of 8 Weeks Resistance Exercise on GSH, SOD, TBARS Activities and GLUT2 mRNA Expression of Pancreas in OLETF Rats
    Min-Ki Lee, Jin-Hwan Yoon
    The Korean Journal of Physical Education.2017; 56(3): 551.     CrossRef
  • Determining the Factors that Influence the Insulin Requirements in Type 2 Diabetic Patients
    Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
    Endocrinology and Metabolism.2010; 25(2): 110.     CrossRef
  • The Effects of Weight Training by Intensity for 8 Weeks of Metabolic Syndrome Factor Improvement in Overweight High School Students

    Journal of Life Science.2009; 19(4): 492.     CrossRef
Clinical Implication of Adiponectin.
Soo Lim, Hak Chul Jang
Korean Diabetes J. 2008;32(2):85-97.   Published online April 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.2.85
  • 2,271 View
  • 31 Download
  • 5 Crossref
AbstractAbstract PDF
Adipose tissue is now considered as an active hormone-secreting organ, which secretes a number of biologically active adipokines such as free fatty acids, leptin, tumor necrosis factor alpha (TNFalpha), interleukin-6, plasminogen activator inhibitor-1, adiponectin and retinol binding protein 4 (RBP4). Among these, adiponectin has attracted considerable attention as an adipokine that has important role in the development of type 2 diabetes, atherosclerosis and cardiovascular diseases. Adiponectin was discovered to be the most abundant adipose-specific transcript. Many epidemiological and clinical studies have demonstrated that serum levels of adiponectin are inversely associated with body weight, especially abdominal visceral fat accumulation. Studies among Japanese and Pima Indians have reported lower concentrations of adiponectin in patients with type 2 diabetes than in those with normal glucose tolerance. A low level of adiponectin was found to be a significant risk factor for the development of cardiovascular events in the Korean patients with type 2 diabetes. We recently published that exercise, having an insulin-sensitizing effect, could be a good therapy to prevent or delay diabetes and cardiovascular diseases in middle-aged women through the modification of adiponectin. These results suggest that the clinical implication of adiponectin. A number of studies have been conducted to clarify the biological role of adiponectin. Recent studies have showed that adiponectin has anti-inflammatory, anti-atherogenic, and glucose-lowering properties. Taken together, it is conceivable that adiponectin plays as a backbone of metabolic syndrome. Finally, pleiotropic functions of adiponectin may possibly serve to prevent and treat atherosclerosis, type 2 diabetes and cardiovascular diseases. Furthermore, enhancement of adiponectin secretion or action may be a good therapeutic target for preventing type 2 diabetes or cardiovascular diseases.

Citations

Citations to this article as recorded by  
  • Effects of the Serum Adiponectin to Tumor Necrosis Factor-α (TNF-α) Ratio on Carotid Intima-Media Thickness in Newly Diagnosed Type 2 Diabetic Patients
    Kwang Youn Kim, Jung Ae Hong, Ha Won Hwang, Sun Ho Lee, Ju Ri Park, Sung Hoon Yu, Jun Goo Kang, Ohk Hyun Ryu, Seong Jin Lee, Eun Gyung Hong, Doo-Man Kim, Jae Myung Yoo, Sung Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Chul Sik Kim
    Journal of Lipid and Atherosclerosis.2015; 4(1): 7.     CrossRef
  • TNF-α polymorphisms and coronary artery disease: Association study in the Korean population
    Ho-Chan Cho, Gyeongim Yu, Mi-Young Lee, Hye-Soon Kim, Dong-Hoon Shin, Yoon-Nyun Kim
    Cytokine.2013; 62(1): 104.     CrossRef
  • The Effect of Visceral Fat Area and Adipocytokines on Acute Myocardial Infarction: A Case-Control Study in Adult Korean Population
    Kang-Kon Lee, Young-Sung Suh, Keun-Sang Yum
    The Korean Journal of Obesity.2012; 21(1): 57.     CrossRef
  • Impact of Serum Adiponectin Concentration on Progression of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus
    Chul Sik Kim, Ju Ri Park, Sung Hoon Yu, Jun Goo Kang, Ohk Hyun Ryu, Seong Jin Lee, Eun Gyung Hong, Doo-Man Kim, Jae Myung Yoo, Sung Hee Ihm, Moon Gi Choi, Hyung Joon Yoo
    Endocrinology and Metabolism.2012; 27(1): 31.     CrossRef
  • Novel Adipokines
    Kyung Mook Choi
    Journal of Korean Endocrine Society.2008; 23(4): 219.     CrossRef
Insulin Resistance in Polycystic Ovary Syndrome.
Yeon Ah Sung
Korean Diabetes J. 2008;32(1):1-6.   Published online February 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.1.1
  • 2,121 View
  • 31 Download
  • 5 Crossref
AbstractAbstract PDF
Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder in women of reproductive age and now recognized as an important metabolic and reproductive disorder. The majority of women with PCOS have insulin resistance and this is regarded to have a central etiological role in PCOS. Insulin resistance and concomitant hyperinsulinemia modifies reproductive function by driving androgen production, suppression of sex hormone-binding globulin (SHBG) and disruption of insulin signaling pathways in the central nervous system. Insulin resistance, together with defects in insulin secretion, confers markedly increased risk for type 2 diabetes mellitus and metabolic syndrome. There are post-binding defects in insulin receptor signaling, with selective resistance to insulin's metabolic actions and preserved other actions. Genetic and environmental abnormalities interact to produce peripheral insulin resistance in PCOS. The numerous in vivo and in vitro data supporting the central role of insulin resistance in the pathogenesis of PCOS have led a new therapy for PCOS with insulin-sensitizing agents.

Citations

Citations to this article as recorded by  
  • Epidemiology and Diagnostic Criteria of Polycystic Ovary Syndrome
    Hyejin Lee, Yeon-Ah Sung
    The Journal of Korean Diabetes.2015; 16(3): 189.     CrossRef
  • Evaluation of Apelin and Insulin Resistance in Patients with PCOS and Therapeutic Effect of Drospirenone-Ethinylestradiol Plus Metformin
    Xianchang Sun, Xingguo Wu, Yan Zhou, Xinyan Yu, Wenjuan Zhang
    Medical Science Monitor.2015; 21: 2547.     CrossRef
  • Hyperandrogenism in Women: Polycystic Ovary Syndrome
    Yeon-Ah Sung
    Hanyang Medical Reviews.2012; 32(4): 197.     CrossRef
  • Adiponectin in Women with Polycystic Ovary Syndrome
    Hyun-Young Shin, Duk-Chul Lee, Ji-Won Lee
    Korean Journal of Family Medicine.2011; 32(4): 243.     CrossRef
  • Polycystic Ovary Syndrome in Korean Women: Clinical Characteristics and Diagnostic Criteria
    Yeon-Ah Sung
    Endocrinology and Metabolism.2011; 26(3): 203.     CrossRef
The Role of Glomerular Podocytes in Diabetic Nephropathy.
Eun Young Lee, Choon Hee Chung
Korean Diabetes J. 2007;31(6):451-454.   Published online November 1, 2007
DOI: https://doi.org/10.4093/jkda.2007.31.6.451
  • 2,097 View
  • 19 Download
  • 3 Crossref
AbstractAbstract PDF
Diabetic nephropathy is the most common cause of end-stage renal disease and accounts for significant morbidity and mortality among individuals with diabetes mellitus. Therefore, the clarification of the pathogenesis of diabetic nephropathy is an urgent issue. Podocytes cover the outer layer of the glomerulus and maintain its integrity so that fluid and toxins exit in urine, but cells and important proteins are kept in the blood stream. Diabetes mellitus alters this structure, it becomes scarred and then the ability of the kidney to clear toxins is lost. Recent evidence shows that early in diabetes the podocyte number is reduced, areas of the glomerular basement membrane are denuded, and podocyte number predicts long-term urinary albumin excretion in the patients with diabetes and microalbuminuria. These results suggest that podocytes play a critical role in the early stage of diabetic nephropathy. It is the purpose of this article to review the pathogenetic role of podocytes in diabetic nephropathy.

Citations

Citations to this article as recorded by  
  • Inhibition of dipeptidyl peptidase-4 (DPP4), antioxidant, antiglycation and anti-inflammatory effect of Ferulic acid against streptozotocin toxicity mediate nephropathy in diabetic rats
    Maryam A. AL-Ghamdi, Said S. Moselhy
    Environmental Science and Pollution Research.2022; 30(12): 33942.     CrossRef
  • Study of Antiglycation, Hypoglycemic, and Nephroprotective Activities of the Green Dwarf Variety Coconut Water (Cocos nucifera L.) in Alloxan-Induced Diabetic Rats
    Isabella F.D. Pinto, Railmara P. Silva, Adriano de B. Chaves Filho, Lucas S. Dantas, Vanderson S. Bispo, Isaac A. Matos, Felipe A.M. Otsuka, Aline C. Santos, Humberto Reis Matos
    Journal of Medicinal Food.2015; 18(7): 802.     CrossRef
  • Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes
    Ran Choi, Bo Hwan Kim, Jarinyaporn Naowaboot, Mi Young Lee, Mi Ri Hyun, Eun Ju Cho, Eun Soo Lee, Eun Young Lee, Young Chul Yang, Choon Hee Chung
    Experimental and Molecular Medicine.2011; 43(12): 676.     CrossRef
Non-drug Intervention in Lipid Management: Dietary Portfolio.
In Ju Kim
Korean Diabetes J. 2007;31(5):377-382.   Published online September 1, 2007
DOI: https://doi.org/10.4093/jkda.2007.31.5.377
  • 1,518 View
  • 19 Download
AbstractAbstract PDF
Non-Pharmaceutical interventions are essential in lipid management. The NCEP recommends the following three tiered approach to lipid management: 1. Institution of therapeutic lifestyle changes (TLC); 2. Use of non-drug adjuncts, including viscous fibers and plant sterol/stanol products; and 3. Drug therapy when required to reach treatment goals. Even though non-drug approaches often receive minimal attention in clinical practice, the efficacy of non-drug therapies is not so small. Non-drug adjuncts are known to reduce LDL cholesterol as follows: 12.5% for 45 g of soy protein/d; 6% to 7% for 9 to 10 g of psyllium/d, with smaller reductions for other viscous fibers; 10% for 1 to 2 g of plant sterols/d and 1% for 10 g almonds/d. Recently, combining these foods in a single dietary portfolio decreased LDL cholesterol and CRP similarly to the extent which achieved by a usual dose of a statin. This dietary portfolio can be regarded as an effective non-drug approach to reduce the risk of cardiovascular disease.
Peroxisome Proliferator Activated Receptor-delta (PPAR-delta).
Kyung Mook Choi
Korean Diabetes J. 2007;31(4):297-301.   Published online July 1, 2007
DOI: https://doi.org/10.4093/jkda.2007.31.4.297
  • 2,071 View
  • 17 Download
  • 1 Crossref
AbstractAbstract PDF
The development of novel treatments for the metabolic syndrome is imminent for decreasing the prevalence of type 2 diabetes and cardiovascular disease. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor super-family of ligand-induced transcription factors. Among them, PPAR-alpha and PPAR-gamma are therapeutic targets for dyslipidemia and insulin resistance. Recent studies have uncovered a dual benefit of PPAR-delta for both dyslipidemia and insulin resistance. Furthermore, PPAR-delta enhances fatty acid oxidation and energy uncoupling in adipose tissue and muscle. PPAR-delta activation seems to operate similarly to the caloric restriction and prolonged exercise. Combined effects of PPAR-delta make it a promising therapeutic target for the metabolic syndrome, and ongoing studies about PPAR-delta will improve our knowledge of the physiologic regulation of whole body energy metabolism.

Citations

Citations to this article as recorded by  
  • Novel Cinnamic Acid Derivatives as Potential PPARδ Agonists for Metabolic Syndrome: Design, Synthesis, Evaluation and Docking Studies
    Ajay Chauhan, Ajmer S. Grewal, Deepti Pandita, Viney Lather
    Current Drug Discovery Technologies.2020; 17(3): 338.     CrossRef
Mitochondrial Gene Therapy.
Kyung Soo Ko
Korean Diabetes J. 2007;31(3):187-192.   Published online May 1, 2007
DOI: https://doi.org/10.4093/jkda.2007.31.3.187
  • 1,490 View
  • 24 Download
AbstractAbstract PDF
Mitochondrial dysfunction contributes to a large variety of human disorders, ranging from neurodegenerative and neuromuscular diseases, obesity, and diabetes to ischemia-reperfusion injury and cancer. Increasing pharmacological efforts toward therapeutic interventions have been made leading to the emergence of 'Mitochondrial Medicine' as a new field of biomedical research. The identification of molecular mitochondrial drugs targets in combination with the development of methods for selectively delivering biologically active molecules to the site of mitochondria will eventually launch a multitude of new therapies for the treatment of mitochondria-related diseases, which are based either on the selective protection, repair, or eradication of cells. Yet, while tremendous efforts are being undertaken to identify new mitochondrial drugs and drug targets, the development of mitochondria-specific drug carrier systems is lagging behind. To ensure a high efficiency of current and future mitochondrial therapeutics, delivery systems need to be developed, which are able to selectively transport biologically active molecules to and into mitochondria within living cells.

Diabetes Metab J : Diabetes & Metabolism Journal