The burgeoning epidemic of metabolic disease causes significant societal and individual morbidity and threatens the stability of health care systems around the globe. Efforts to understand the factors that contribute to metabolic derangements are critical for reversing these troubling trends. While excess caloric consumption and physical inactivity superimposed on a susceptible genetic background are central drivers of this crisis, these factors alone fail to fully account for the magnitude and rapidity with which metabolic diseases have increased in prevalence worldwide. Recent epidemiological evidence implicates endocrine disrupting chemicals in the pathogenesis of metabolic diseases. These compounds represent a diverse array of chemicals to which humans are exposed via multiple routes in adulthood and during development. Furthermore, a growing ensemble of animal- and cell-based studies provides preclinical evidence supporting the hypothesis that environmental contaminants contribute to the development of metabolic diseases, including diabetes. Herein are reviewed studies linking specific endocrine disruptors to impairments in glucose homeostasis as well as tying these compounds to disturbances in insulin secretion and impairments in insulin signal transduction. While the data remains somewhat incomplete, the current body of evidence supports the hypothesis that our chemically polluted environment may play a contributing role in the current metabolic crisis.

Citations

Citations to this article as recorded by  

• Effects of Inorganic Arsenic on Type 2 Diabetes Mellitus In Vivo: the Roles and Mechanisms of miRNAs
  Jackson Sira, Xiaodan Zhang, Lin Gao, Therese Martin Cheteu Wabo, Jinyu Li, Caselia Akiti, Wei Zhang, Dianjun Sun
  Biological Trace Element Research.2024; 202(1): 111.     CrossRef
• Relationships Between Urinary Metals and Diabetes Traits Among Mexican Americans in Starr County, Texas, USA
  Margaret C. Weiss, Yu-Hsuan Shih, Molly Scannell Bryan, Brian P. Jackson, David Aguilar, Craig L. Hanis, Maria Argos, Robert M. Sargis
  Biological Trace Element Research.2023; 201(2): 529.     CrossRef
• Prenatal arsenic exposure induces immunometabolic alteration and renal injury in rats
  Radha Dutt Singh, Ratnakar Tiwari, Vineeta Sharma, Hafizurrahman Khan, Siddhartha Gangopadhyay, Sukhveer Singh, Kavita Koshta, Shagun Shukla, Nidhi Arjaria, Kapil Mandrah, Pankaj Ramji Jagdale, Satyakam Patnaik, Somendu Kumar Roy, Dhirendra Singh, Ashok K
  Frontiers in Medicine.2023;[Epub]     CrossRef
• Arsenic metabolism, diabetes prevalence, and insulin resistance among Mexican Americans: A mendelian randomization approach
  Margaret C. Weiss, Yu-Hsuan Shih, Molly Scannell Bryan, Brian P. Jackson, David Aguilar, Eric L. Brown, Goo Jun, Craig L. Hanis, Maria Argos, Robert M. Sargis
  Environmental Advances.2023; 12: 100361.     CrossRef
• Transportation-related Environmental Mixtures and Diabetes Prevalence and Control in Urban/Metropolitan Counties in the United States
  Margaret C Weiss, Sneha Adusumilli, Jyotsna S Jagai, Robert M Sargis
  Journal of the Endocrine Society.2023;[Epub]     CrossRef
• 24-Epibrassinolide alleviates diazinon oxidative damage by escalating activities of antioxidant defense systems in maize plants
  Saeed Karami Mehrian, Nasser Karimi, Fatemeh Rahmani
  Scientific Reports.2023;[Epub]     CrossRef
• Relationship Between Serum Levels of Arsenic, Cadmium, and Mercury and Body Mass Index and Fasting Plasma Glucose in a Mexican Adult Population
  Héctor Hernández-Mendoza, Héctor Edmundo Álvarez-Loredo, Elizabeth Teresita Romero-Guzmán, Darío Gaytán-Hernández, Consuelo Chang-Rueda, Israel Martínez-Navarro, Bertha Irene Juárez-Flores, María Judith Rios-Lugo
  Biological Trace Element Research.2022; 200(12): 4916.     CrossRef
• Health Behavior, Level of Hemoglobin A1c, and Quality of Life Among Agricultural Workers of Various Ethnicities in Thai Border Communities
  Sorawit Boonyathee, Parichat Ong-Artborirak, Katekaew Seangpraw, Prakasit Tonchoy, Supakan Kantow, Sasivimol Bootsikeaw, Nisarat Auttama, Monchanok Choowanthanapakorn, Dech Dokpuang, Pitakpong Panta
  Frontiers in Medicine.2022;[Epub]     CrossRef
• Perfluorooctanoic acid promotes pancreatic β cell dysfunction and apoptosis through ER stress and the ATF4/CHOP/TRIB3 pathway
  Xiaowei He, Dan Wu, Yanan Xu, Yaqin Zhang, Yue Sun, Xiaoai Chang, Yunxia Zhu, Wei Tang
  Environmental Science and Pollution Research.2022; 29(56): 84532.     CrossRef
• Increased gut serotonin production in response to bisphenol A structural analogs may contribute to their obesogenic effects
  Nicole G. Barra, Yun Han Kwon, Katherine M. Morrison, Gregory R. Steinberg, Michael G. Wade, Waliul I Khan, Mathilakath M. Vijayan, Jonathan D. Schertzer, Alison C. Holloway
  American Journal of Physiology-Endocrinology and Metabolism.2022; 323(1): E80.     CrossRef
• Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors
  Kévin Bernal, Charbel Touma, Chedi Erradhouani, Talía Boronat‐Belda, Lucas Gaillard, Sara Al Kassir, Hélène Le Mentec, Corinne Martin‐Chouly, Normand Podechard, Dominique Lagadic‐Gossmann, Sophie Langouet, François Brion, Anja Knoll‐Gellida, Patrick J. Ba
  FEBS Letters.2022; 596(24): 3107.     CrossRef
• Low-Dose Dioxin Reduced Glucose Uptake in C2C12 Myocytes: The Role of Mitochondrial Oxidative Stress and Insulin-Dependent Calcium Mobilization
  Suyeol Im, Sora Kang, Ji Hwan Kim, Seung Jun Oh, Youngmi Kim Pak
  Antioxidants.2022; 11(11): 2109.     CrossRef
• Environmental toxicants in the brain: A review of astrocytic metabolic dysfunction
  Mondona S. McCann, Kathleen A. Maguire-Zeiss
  Environmental Toxicology and Pharmacology.2021; 84: 103608.     CrossRef
• Environmental pollution and diabetes mellitus
  Amany El-Sikaily, Mohamed Helal
  World Journal of Meta-Analysis.2021; 9(3): 234.     CrossRef
• Effects of PCB126 on Adipose-to-Muscle Communication in an in Vitro Model
  Audrey Caron, Fozia Ahmed, Vian Peshdary, Léa Garneau, Ella Atlas, Céline Aguer
  Environmental Health Perspectives.2020;[Epub]     CrossRef
• Interventions to Address Environmental Metabolism-Disrupting Chemicals: Changing the Narrative to Empower Action to Restore Metabolic Health
  Robert M. Sargis, Jerrold J. Heindel, Vasantha Padmanabhan
  Frontiers in Endocrinology.2019;[Epub]     CrossRef
• Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells
  Fei Wang, Chong Chang, Ruobi Li, Zhen Zhang, Hongmei Jiang, Ni Zeng, Daochuan Li, Liping Chen, Yongmei Xiao, Wen Chen, Qing Wang
  Toxicology.2019; 424: 152236.     CrossRef
• Percentage fractions of urinary di(2-ethylhexyl) phthalate metabolites: Association with obesity and insulin resistance in Korean girls
  Shin-Hye Kim, Ji-won On, Heesoo Pyo, Kyung Soo Ko, Jong Chul Won, Jiyeon Yang, Mi Jung Park, Elena Baixeras
  PLOS ONE.2018; 13(11): e0208081.     CrossRef
• Association between diabetes and pesticides: a case-control study among Thai farmers
  Chudchawal Juntarawijit, Yuwayong Juntarawijit
  Environmental Health and Preventive Medicine.2018;[Epub]     CrossRef
• Environmental toxicant exposures and type 2 diabetes mellitus: Two interrelated public health problems on the rise
  Marcelo G. Bonini, Robert M. Sargis
  Current Opinion in Toxicology.2018; 7: 52.     CrossRef
• Unravelling the Effect of p,p′-Dichlorodiphenyldichloroethylene (DDE) in Hypertension of Wistar Rats
  Carla Sá, Diogo Pestana, Conceição Calhau, Ana Faria
  Journal of Agricultural and Food Chemistry.2018; 66(48): 12847.     CrossRef
• Exposure to bisphenol A is directly associated with inflammation in healthy Korean adults
  Yong Jun Choi, Kyoung Hwa Ha, Dae Jung Kim
  Environmental Science and Pollution Research.2017; 24(1): 284.     CrossRef
• Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p’-DDE
  Diogo Pestana, Diana Teixeira, Manuela Meireles, Cláudia Marques, Sónia Norberto, Carla Sá, Virgínia C. Fernandes, Luísa Correia-Sá, Ana Faria, Luísa Guardão, João T. Guimarães, Wendy N. Cooper, Ionel Sandovici, Valentina F. Domingues, Cristina Delerue-Ma
  Scientific Reports.2017;[Epub]     CrossRef
• BDE-47 and BDE-85 stimulate insulin secretion in INS-1 832/13 pancreatic β-cells through the thyroid receptor and Akt
  Shpetim Karandrea, Huquan Yin, Xiaomei Liang, Emma A. Heart
  Environmental Toxicology and Pharmacology.2017; 56: 29.     CrossRef
• Association between Blood Mercury Level and Visceral Adiposity in Adults
  Jong Suk Park, Kyoung Hwa Ha, Ka He, Dae Jung Kim
  Diabetes & Metabolism Journal.2017; 41(2): 113.     CrossRef
• Polychlorinated biphenyls and links to cardiovascular disease
  Jordan T. Perkins, Michael C. Petriello, Bradley J. Newsome, Bernhard Hennig
  Environmental Science and Pollution Research.2016; 23(3): 2160.     CrossRef
• Polychlorinated biphenyl 126 exposure in L6 myotubes alters glucose metabolism: a pilot study
  Jean-François Mauger, Lucien Nadeau, Audrey Caron, Natalie Ann Chapados, Céline Aguer
  Environmental Science and Pollution Research.2016; 23(8): 8133.     CrossRef
• Direct effect of p,p'- DDT on mice liver
  Bárbara Arroyo-Salgado, Jesús Olivero-Verbel, Angélica Guerrero-Castilla
  Brazilian Journal of Pharmaceutical Sciences.2016; 52(2): 287.     CrossRef
• More β-cell researchers are wanted!
  Susumu Seino
  Diabetology International.2016; 7(2): 101.     CrossRef
• New risk factors for obesity and diabetes: Environmental chemicals
  Ja Young Jeon, Kyoung Hwa Ha, Dae Jung Kim
  Journal of Diabetes Investigation.2015; 6(2): 109.     CrossRef
• Dietary Exposure to the Endocrine Disruptor Tolylfluanid Promotes Global Metabolic Dysfunction in Male Mice
  Shane M. Regnier, Andrew G. Kirkley, Honggang Ye, Essam El-Hashani, Xiaojie Zhang, Brian A. Neel, Wakanene Kamau, Celeste C. Thomas, Ayanna K. Williams, Emily T. Hayes, Nicole L. Massad, Daniel N. Johnson, Lei Huang, Chunling Zhang, Robert M. Sargis
  Endocrinology.2015; 156(3): 896.     CrossRef
• Impact of Cadmium Exposure on the Association between Lipopolysaccharide and Metabolic Syndrome
  Seung Han, Kyoung Ha, Ja Jeon, Hae Kim, Kwan Lee, Dae Kim
  International Journal of Environmental Research and Public Health.2015; 12(9): 11396.     CrossRef
• A Northern contaminant mixture impairs pancreas function in obese and lean JCR rats and inhibits insulin secretion in MIN6 cells
  Ryan Mailloux, Accalia Fu, Maria Florian, Ivan Petrov, Qixuan Chen, Melanie C. Coughlan, Mahemuti Laziyan, Jin Yan, Don Caldwell, Dominique Patry, Michelle Lalande, Gen-Sheng Wang, William Willmore, Xiaolei Jin
  Toxicology.2015; 334: 81.     CrossRef
• Metabolic disruption in context: Clinical avenues for synergistic perturbations in energy homeostasis by endocrine disrupting chemicals
  Robert M Sargis
  Endocrine Disruptors.2015; 3(1): e1080788.     CrossRef
• Mitochondrial Redox Dysfunction and Environmental Exposures
  Samuel W. Caito, Michael Aschner
  Antioxidants & Redox Signaling.2015; 23(6): 578.     CrossRef
• Transgenerational inheritance of heart disorders caused by paternal bisphenol A exposure
  Marta Lombó, Cristina Fernández-Díez, Silvia González-Rojo, Claudia Navarro, Vanesa Robles, María Paz Herráez
  Environmental Pollution.2015; 206: 667.     CrossRef
• Qizhi Jiangtang Jiaonang Improves Insulin Signaling and Reduces Inflammatory Cytokine Secretion and Reactive Oxygen Species Formation in Insulin Resistant HepG2 Cells
  Xiao-Tian Zhang, Chun-Jiang Yu, Jian-Wei Liu, Yan-Ping Zhang, Chao Zhang, Chen-Xue Song, Jing-Shu Xie, Jing-Ying Sai, Jing-Tong Zheng, Fang Wang
  Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
• Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism
  Rohit A. Sinha, Brijesh K. Singh, Paul M. Yen
  Trends in Endocrinology & Metabolism.2014; 25(10): 538.     CrossRef
• Environmental Endocrine Disruption of Energy Metabolism and Cardiovascular Risk
  Andrew G. Kirkley, Robert M. Sargis
  Current Diabetes Reports.2014;[Epub]     CrossRef

Gestational diabetes mellitus (GDM) reflects defects in insulin secretion in response to the metabolic demands of pregnancy. While GDM is increasingly common worldwide due in large part to the obesity epidemic, its frequency is relatively low in Korean women. In this report, the prevalence and risk factors for GDM, perinatal outcomes, and postpartum course are compared in non-Korean and Korean women. While Koreans and non-Koreans with GDM share pathophysiology and complications, there may be differences in the role of obesity and thus the effectiveness of interventions targeting obesity in GDM women. Further investigations of the effectiveness of weight loss interventions and pharmacotherapy specifically among Korean women are needed. Dietary and other lifestyle data from Korean populations could inform prevention and treatment strategies in other countries which suffer from significantly higher prevalences of GDM.

Citations

Citations to this article as recorded by  

• More Physical Exercise is Required for Overweight or Obese Women with Gestational Diabetes Mellitus to Achieve Good Plasma Glucose Control During Pregnancy: Finding from a Prospective Cohort in Shanghai
  Xiangjin Gao, Xiuqi Zhang, Le Kuai, Qing Yang, Huan Li, Rui Zhang, Bin Li, Ruiping Wang
  Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 3925.     CrossRef
• The role of plasminogen activator inhibitor-1 in gynecological and obstetrical diseases: An update review
  Jiaqi Zhai, Zijian Li, Yue Zhou, Xiuhua Yang
  Journal of Reproductive Immunology.2022; 150: 103490.     CrossRef
• Gestational diabetes in Korea: Temporal trends in prevalence, treatment, and short-term consequences from a national health insurance claims database between 2012 and 2016
  Chan-Hee Jung, Sang-Hee Jung, Dughyun Choi, Bo-Yeon Kim, Chul-Hee Kim, Ji-Oh Mok
  Diabetes Research and Clinical Practice.2021; 171: 108586.     CrossRef
• Maternal Nutrition Status Associated with Pregnancy-Related Adverse Outcomes
  Maria J Miele, Renato T Souza, Iracema M Calderon, Francisco E Feitosa, Debora F Leite, Edilberto A Rocha Filho, Janete Vettorazzi, Jussara Mayrink, Karayna G Fernandes, Matias C Vieira, Rodolfo C Pacagnella, José G. Cecatti
  Nutrients.2021; 13(7): 2398.     CrossRef
• Pregnancy Outcomes of Women Additionally Diagnosed as Gestational Diabetes by the International Association of the Diabetes and Pregnancy Study Groups Criteria
  Min Hyoung Kim, Soo Heon Kwak, Sung-Hoon Kim, Joon Seok Hong, Hye Rim Chung, Sung Hee Choi, Moon Young Kim, Hak C. Jang
  Diabetes & Metabolism Journal.2019; 43(6): 766.     CrossRef
• Environmental neglect: endocrine disruptors as underappreciated but potentially modifiable diabetes risk factors
  Robert M. Sargis, Rebecca A. Simmons
  Diabetologia.2019; 62(10): 1811.     CrossRef
• Prediction of gestational diabetes mellitus in the Born in Guangzhou Cohort Study, China
  Kimberly K. Schaefer, Wanqing Xiao, Qiaozhu Chen, Jianrong He, Jinhua Lu, Fanfan Chan, Niannian Chen, Mingyang Yuan, Huimin Xia, Kin Bong Hubert Lam, Jane E. Hirst, Xiu Qiu
  International Journal of Gynecology & Obstetrics.2018; 143(2): 164.     CrossRef
• Effects of the interaction between glycated haemoglobin genetic risk score and postpartum weight reduction on glycaemic changes: A gene–weight interaction analysis
  Liyuan Han, Donghui Duan, Shuang Zhang, Weiqin Li, Leishen Wang, Huikun Liu, Junhong Leng, Nan Li, Xiaoyun Shang, Gang Hu, Lu Qi
  Diabetes, Obesity and Metabolism.2018; 20(12): 2733.     CrossRef
• Adipokines and Insulin Resistance According to Characteristics of Pregnant Women with Gestational Diabetes Mellitus
  Eon Ju Jeon, Seong Yeon Hong, Ji Hyun Lee
  Diabetes & Metabolism Journal.2017; 41(6): 457.     CrossRef
• The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis
  Aline Martins de Carvalho, Ping Shao, Huikun Liu, Han-Ling Cheng, Yan Zheng, Junhong Leng, Weiqin Li, Tao Huang, Tiange Wang, Leishen Wang, Shuang Zhang, Gang Hu, Lu Qi
  Scientific Reports.2017;[Epub]     CrossRef
• Simple Screening Using Ultrasonography for Prediction of Gestational Diabetes Mellitus
  Seung Min Chung, Jun Sung Moon
  Diabetes & Metabolism Journal.2017; 41(6): 438.     CrossRef
• Prevention of type 2 diabetes mellitus in women with previous gestational diabetes mellitus
  Joon Ho Moon, Soo Heon Kwak, Hak C. Jang
  The Korean Journal of Internal Medicine.2017; 32(1): 26.     CrossRef
• Expression of intercellular adhesion molecule-1 in umbilical vascular of pregnant women with gestational diabetes mellitus and the clinical significance
  Fei Teng, Jinfang Wu, Min Wei, Yongxiu Yang
  Experimental and Therapeutic Medicine.2017;[Epub]     CrossRef
• Diagnostic value of haemoglobin A1c in post‐partum screening of women with gestational diabetes mellitus
  K.‐S. Kim, S.‐K. Kim, Y.‐W. Cho, S. W. Park
  Diabetic Medicine.2016; 33(12): 1668.     CrossRef
• Comparison of the performance of screening test for gestational diabetes in singleton versus twin pregnancies
  Yun Ji Jung, Ja Young Kwon, Hee Young Cho, Yong-Won Park, Young-Han Kim
  Obstetrics & Gynecology Science.2015; 58(6): 439.     CrossRef
• Circulating retinol-binding protein 4 levels in gestational diabetes mellitus: a meta-analysis of observational studies
  Qi-Tao Huang, Qiong Huang, Wei Luo, Fei Li, Li-Lin Hang, Yan-Hong Yu, Mei Zhong
  Gynecological Endocrinology.2015; 31(5): 337.     CrossRef
• Transition of maternal and child nutrition in Asia
  Pattanee Winichagoon
  Current Opinion in Clinical Nutrition and Metabolic Care.2015; 18(3): 312.     CrossRef
• Diabetes in Asians
  Eun-Jung Rhee
  Endocrinology and Metabolism.2015; 30(3): 263.     CrossRef
• The rs2237892 Polymorphism in KCNQ1 Influences Gestational Diabetes Mellitus and Glucose Levels: A Case-Control Study and Meta-Analysis
  Deng Ao, Hai-jun Wang, Li-fang Wang, Jie-yun Song, Hui-xia Yang, Yan Wang, Marta Letizia Hribal
  PLOS ONE.2015; 10(6): e0128901.     CrossRef
• Late Preterm Infants' Outcome Born from Mothers with Positive Screening but Negative Diagnostic Test for Gestational Diabetes
  Jeong Min Lee, Bo Seon Seo, Eun Sun Kim
  Korean Journal of Perinatology.2015; 26(3): 200.     CrossRef

Atherothrombotic complications are important causes of morbidity and mortality in diabetic patients. Diabetes has been considered to be a prothrombotic status. Several factors contribute to the prothrombotic condition, such as increasing coagulation, impaired fibrinolysis, endothelial dysfunction, and platelet hyperreactivity. Among the factors that contribute to the prothrombotic status in diabetes, altered platelet function plays a crucial role. Although understanding platelet function abnormalities in diabetes still remains as a challenge, more attention should be focused on platelet function for effective management and the prediction of atherothrombotic events in diabetic patients. This review will provide an overview on the current status of knowledge of platelet function abnormalities and clinical marker of platelet hyperreactivity in patients with diabetes.

Citations

Citations to this article as recorded by  

• Prediction of type 2 diabetes mellitus using hematological factors based on machine learning approaches: a cohort study analysis
  Amin Mansoori, Toktam Sahranavard, Zeinab Sadat Hosseini, Sara Saffar Soflaei, Negar Emrani, Eisa Nazar, Melika Gharizadeh, Zahra Khorasanchi, Sohrab Effati, Mark Ghamsary, Gordon Ferns, Habibollah Esmaily, Majid Ghayour Mobarhan
  Scientific Reports.2023;[Epub]     CrossRef
• Platelet P2Y1 receptor exhibits constitutive G protein signaling and β-arrestin 2 recruitment
  Agnès Ribes, Cédric Garcia, Marie-Pierre Gratacap, Evi Kostenis, Laurent O. Martinez, Bernard Payrastre, Jean-Michel Sénard, Céline Galés, Véronique Pons
  BMC Biology.2023;[Epub]     CrossRef
• Sex differences in the relationship between platelet count and type 2 diabetes risk in community‐dwelling adults: Longitudinal findings over 14 years
  Eun Kyeong Yun, In‐Ho Seo, Hye Sun Lee, So‐Young Seol, Yong‐Jae Lee
  Diabetes/Metabolism Research and Reviews.2023;[Epub]     CrossRef
• Platelet Glycoprotein-Ib (GPIb) May Serve as a Bridge between Type 2 Diabetes Mellitus (T2DM) and Atherosclerosis, Making It a Potential Target for Antiplatelet Agents in T2DM Patients
  Muttia Amalia, Meidi Utami Puteri, Fadlina Chany Saputri, Rani Sauriasari, Bambang Widyantoro
  Life.2023; 13(7): 1473.     CrossRef
• Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients
  Esraa Habiba, Samia Ali, Yehia Ghanem, Ola Sharaki, Wafaa Hewedy
  Canadian Journal of Physiology and Pharmacology.2023; 101(11): 610.     CrossRef
• Characteristics of cerebral ischemic stroke based on moyamoya disease and atherosclerosis-associated intracranial arterial stenosis
  Zhiying Chen, Xiaoqin Wu, Da Zhou, Shuling Shang, Yuchuan Ding, Xunming Ji, Ran Meng
  Neurological Sciences.2022; 43(2): 1087.     CrossRef
• Basic Coagulation Profiles and Platelet Parameters Among Adult Type 1 and Type 2 Diabetes Patients at Dessie Referral Hospital, Northeast Ethiopia: Comparative Cross-Sectional Study
  Hussen Ebrahim, Fikir Asrie, Zegeye Getaneh
  Journal of Blood Medicine.2021; Volume 12: 33.     CrossRef
• Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials
  Huanhuan Lv, Junyu Liu, Chenxiao Zhen, Yijia Wang, Yunpeng Wei, Weihao Ren, Peng Shang
  Cell Proliferation.2021;[Epub]     CrossRef
• Diabetes and hypertension: Pivotal involvement of purinergic signaling
  Karine Paula Reichert, Milagros Fanny Vera Castro, Charles Elias Assmann, Nathieli Bianchin Bottari, Vanessa Valéria Miron, Andréia Cardoso, Naiara Stefanello, Vera Maria Melchiors Morsch, Maria Rosa Chitolina Schetinger
  Biomedicine & Pharmacotherapy.2021; 137: 111273.     CrossRef
• The hemostatic parameters in pregnant women with different types of diabetes mellitus
  R. V. Kapustin, E. V. Kopteeva, O. N. Arzhanova, A. V. Tiselko, N. Е. Androsova, T. I. Oparina
  Diabetes mellitus.2021; 24(3): 251.     CrossRef
• Comparison of the progressive changes in hemogram parameters of normal glycemic and gestational diabetic patients throughout the first two trimesters and predictive ability of these indices for gestational diabetes mellitus
  Pelin AYTAN, Seyran BOZKURT BABUŞ, Özde SAKARYA, Revan Sabri ÇİFTÇİ, Kasım AKAY, Hakan AYTAN
  Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi.2020; 17(4): 533.     CrossRef
• A Pilot Study on the Effect of Anti-Thrombopoietin Antibody on Platelet Count in Patients with Type 2 Diabetes
  Takuya Fukuda, Masahide Hamaguchi, Takafumi Osaka, Yoshitaka Hashimoto, Emi Ushigome, Mai Asano, Masahiro Yamazaki, Eriko Fukuda, Kei Yamaguchi, Koji Ogawa, Naoki Goshima, Michiaki Fukui
  Molecules.2020; 25(7): 1667.     CrossRef
• Patient with diabetes after acute coronary event. How to improve forecast?
  O. L. Barbarash
  Medical alphabet.2019; 1(3): 6.     CrossRef
• Enhanced Platelet Sensitivity to IGF-1 in Patients with Type 2 Diabetes Mellitus
  N. Gligorijevic, D. Robajac, O. Nedic
  Biochemistry (Moscow).2019; 84(10): 1213.     CrossRef
• Comprehensive Quality Control of the Regenerative Therapy Using Platelet Concentrates: The Current Situation and Prospects in Japan
  Tomoyuki Kawase, Kazuhiro Okuda
  BioMed Research International.2018; 2018: 1.     CrossRef
• Changes in platelet morphology indices in relation to duration of disease and glycemic control in children with type 1 diabetes mellitus
  Vybhav Venkatesh, Rakesh Kumar, Dinesh Kumar Varma, Prateek Bhatia, Jaivinder Yadav, Devi Dayal
  Journal of Diabetes and its Complications.2018; 32(9): 833.     CrossRef
• Quantifying Platelet Margination in Diabetic Blood Flow
  Hung-Yu Chang, Alireza Yazdani, Xuejin Li, Konstantinos A.A. Douglas, Christos S. Mantzoros, George Em Karniadakis
  Biophysical Journal.2018; 115(7): 1371.     CrossRef
• Redox Proteomics and Platelet Activation: Understanding the Redox Proteome to Improve Platelet Quality for Transfusion
  Giona Sonego, Mélanie Abonnenc, Jean-Daniel Tissot, Michel Prudent, Niels Lion
  International Journal of Molecular Sciences.2017; 18(2): 387.     CrossRef
• Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets
  Amanda J. Unsworth, Alexander P. Bye, Dionne S. Tannetta, Michael J.R. Desborough, Neline Kriek, Tanya Sage, Harriet E. Allan, Marilena Crescente, Parveen Yaqoob, Timothy D. Warner, Chris I. Jones, Jonathan M. Gibbins
  Arteriosclerosis, Thrombosis, and Vascular Biology.2017; 37(8): 1482.     CrossRef
• Aspirin in the prevention of cardiovascular events in patients with diabetes
  David S. H. Bell
  Postgraduate Medicine.2016; 128(2): 180.     CrossRef
• ROLE OF NITRIC OXIDE METABOLITES WITHIN THE IMPACT OF THE SUB-TOXIC SUCCINAMIDES DOSES ON STATE OF HEMOSTASIS
  I.А. Palagina, M.Y. Kudria, О.S. Lаlymеnkо
  Fiziolohichnyĭ zhurnal.2016; 62(6): 34.     CrossRef
• Influence of genetic variations in platelet glycoproteins and eNOS in the development of arterial ischaemia of lower limbs in type 2 diabetes mellitus patients
  Virginia Carvalhais, Ema Ruivães, Luis Bernardo Pina-Cabral, Bárbara Mesquita, Flávio Oliveira, Maria Céu Monteiro, Maria Begoña Criado
  The Foot.2016; 29: 42.     CrossRef
• Circulating endothelial progenitor cells and angiogenic factors in diabetes complicated diabetic foot and without foot complications
  Arleta Kulwas, Ewelina Drela, Wiesław Jundziłł, Barbara Góralczyk, Barbara Ruszkowska-Ciastek, Danuta Rość
  Journal of Diabetes and its Complications.2015; 29(5): 686.     CrossRef
• Cerebrovascular diseases: perspectives of pathogenetic metabolic haemangiocorrective treatment
  M. M. Tanashyan, O. V. Lagoda, K. V. Antonova
  Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2015; 115(9): 70.     CrossRef
• Letter: Clinical Marker of Platelet Hyperreactivity in Diabetes Mellitus (Diabetes Metab J2013;37:423-8)
  Cengiz Beyan, Esin Beyan
  Diabetes & Metabolism Journal.2014; 38(2): 158.     CrossRef
• Response: Clinical Marker of Platelet Hyperreactivity in Diabetes Mellitus (Diabetes Metab J2013;37:423-8)
  Jin Hwa Kim, Hak Yeon Bae, Sang Yong Kim
  Diabetes & Metabolism Journal.2014; 38(2): 160.     CrossRef

Statins are widely prescribed cholesterol-lowering agents, which have been demonstrated to significantly reduce cardiovascular morbidity and mortality. However, recent trials have reported that statins cause worsening of hyperglycemia and increase the risk of new-onset diabetes. The association between the diabetogenic effect of statins with intensive dose and accompanying major risk factors for diabetes has been demonstrated. However, statins do not appear to have a class effect on insulin sensitivity in non-diabetic patients. Numerous mechanisms have been suggested to explain how statins cause β-cell insulin secretory dysfunction and peripheral insulin resistance leading to incident diabetes. According to findings from an aggregate of large clinical trials, the benefits of statin treatment appear to outweigh the risk of new-onset diabetes. Therefore, it would be inappropriate to discontinue the use of statins for prevention of cardiovascular events because of its potential risk for development of incident diabetes. This review addresses the currently available evidence related to statin use and new-onset diabetes from a clinical perspective.

Citations

Citations to this article as recorded by  

• High doses of rosuvastatin induce impaired branched‐chain amino acid catabolism and lead to insulin resistance
  Xue Bai, Xingzhen Long, Fang Song, Baolin Chen, Changcheng Sheng, Cailin Tang, Li Li, Jiaxing Zhang, Rui Zhang, Jiquan Zhang, Jiali Li
  Experimental Physiology.2023; 108(7): 961.     CrossRef
• Statins and the diabetogenic effect (II)
  Nicolae Bacinschi, Ina Guţu, Anastasia Caracaş, Svetlana Latuş, Stela Bacinschi-Gheorghiţă, Aurelia Bacinschi, Dumitru Ştîrba, Olesea Malancea
  Farmacist.ro.2022; 5(208): 14.     CrossRef
• Statins and the diabetogenic effect (I)
  Nicolae Bacinschi, Ina Guţu, Anastasia Caracaş, Svetlana Latuş, Stela Bacinschi-Gheorghiţă, Aurelia Bacinschi, Dumitru Ştîrba, Olesea Malancea
  Farmacist.ro.2022; 4(207): 16.     CrossRef
• Efficacy and Safety of a Fixed-Dose Combination of Candesartan and Rosuvastatin on Blood Pressure and Cholesterol in Patients With Hypertension and Hypercholesterolemia: A Multicenter, Randomized, Double-Blind, Parallel Phase III Clinical Study
  Kyoung Im Cho, Bo Hyun Kim, Yong Hyun Park, Jeong-Cheon Ahn, Sang Hyun Kim, Wook Jin Chung, Weon Kim, Il Suk Sohn, Jin Ho Shin, Yong Jin Kim, Kiyuk Chang, Cheol Woong Yu, Soe Hee Ahn, Seok Yeon Kim, Jae Kean Ryu, Jong Young Lee, Bum Kee Hong, Taek Jong Ho
  Clinical Therapeutics.2019; 41(8): 1508.     CrossRef
• Change in ALT levels after administration of HMG‐CoA reductase inhibitors to subjects with pretreatment levels three times the upper normal limit in clinical practice
  Hyunah Kim, Hyeseon Lee, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung‐Hwan Lee, Jae‐Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun‐Ho Yoon, Hun‐Sung Kim
  Cardiovascular Therapeutics.2018;[Epub]     CrossRef
• Phenotyping of Korean patients with better-than-expected efficacy of moderate-intensity statins using tensor factorization
  Jingyun Choi, Yejin Kim, Hun-Sung Kim, In Young Choi, Hwanjo Yu, Katriina Aalto-Setala
  PLOS ONE.2018; 13(6): e0197518.     CrossRef
• Management of patients with statin intolerance
  Sabine Fischer, Ulrich Julius
  Atherosclerosis Supplements.2017; 30: 33.     CrossRef
• Use of Moderate‐Intensity Statins for Low‐Density Lipoprotein Cholesterol Level above 190 mg/dL at Baseline in Koreans
  Hun‐Sung Kim, Hyeseon Lee, Sue Hyun Lee, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Sun Jung Baik, Hyunah Kim, Seung‐Hwan Lee, Jae Hyoung Cho, In‐Young Choi, Kun‐Ho Yoon, Ju Han Kim
  Basic & Clinical Pharmacology & Toxicology.2017; 121(4): 272.     CrossRef
• Uso de estatinas e o risco de Diabetes Mellitus tipo 2: Revisão Baseada na Evidência
  Susana Silva, Nuno Monteiro
  Revista Brasileira de Medicina de Família e Comunidade.2016; 11(38): 1.     CrossRef
• Association of statin use and stress-induced hyperglycemia in patients with acute ST-elevation myocardial infarction
  Chen Yan, Ma Qin, Yang S Juan, Li Y Tao, Gao M dong, Zeng Zechun, Yang X Chun, Cong H Liang, Liu Yin, Meng Kang
  JRSM Cardiovascular Disease.2016; 5: 204800401663944.     CrossRef
• Statin‐related aminotransferase elevation according to baseline aminotransferases level in real practice in Korea
  H.‐S. Kim, S. H. Lee, H. Kim, S.‐H. Lee, J. H. Cho, H. Lee, H. W. Yim, S.‐H. Kim, I.‐Y. Choi, K.‐H. Yoon, J. H. Kim
  Journal of Clinical Pharmacy and Therapeutics.2016; 41(3): 266.     CrossRef
• Statins and their increased risk of inducing diabetes
  Aris P Agouridis, Michael S Kostapanos, Moses S Elisaf
  Expert Opinion on Drug Safety.2015; 14(12): 1835.     CrossRef
• Effects ofVacciniumBerries on Serum Lipids: A Meta-Analysis of Randomized Controlled Trials
  Yitong Zhu, Ya Miao, Zheying Meng, Yuan Zhong
  Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
• Type 2 Diabetes Mellitus, Metabolic Syndrome, and Mixed Dyslipidemia: How Similar, How Different, and How to Treat?
  Julian Halcox, Anoop Misra
  Metabolic Syndrome and Related Disorders.2015; 13(1): 1.     CrossRef
• How to balance cardiorenometabolic benefits and risks of statins
  Soo Lim, Pyung Chun Oh, Ichiro Sakuma, Kwang Kon Koh
  Atherosclerosis.2014; 235(2): 644.     CrossRef
• Contemporary treatment strategies for Type 2 diabetes-related macrovascular disease
  Andrew MN Walker, Richard M Cubbon, Mark T Kearney
  Expert Review of Endocrinology & Metabolism.2014; 9(6): 641.     CrossRef

Obesity is characterized by excess accumulation of lipids in adipose tissue and other organs, and chronic inflammation associated with insulin resistance and an increased risk of type 2 diabetes. Obesity, type 2 diabetes, and cardiovascular diseases are major health concerns. Resistin was first discovered as an adipose-secreted hormone (adipokine) linked to obesity and insulin resistance in rodents. Adipocyte-derived resistin is increased in obese rodents and strongly related to insulin resistance. However, in contrast to rodents, resistin is expressed and secreted from macrophages in humans and is increased in inflammatory conditions. Some studies have also suggested an association between increased resistin levels and insulin resistance, diabetes and cardiovascular disease. Genetic studies have provided additional evidence for a role of resistin in insulin resistance and inflammation. Resistin appears to mediate the pathogenesis of atherosclerosis by promoting endothelial dysfunction, vascular smooth muscle cell proliferation, arterial inflammation, and formation of foam cells. Indeed, resistin is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. There is also growing evidence that elevated resistin is associated with the development of heart failure. This review will focus on the biology of resistin in rodents and humans, and evidence linking resistin with type 2 diabetes, atherosclerosis, and cardiovascular disease.

Citations

Citations to this article as recorded by  

• Resistin – A Plausible Therapeutic Target in the Pathogenesis of Psoriasis
  Manupati Srikanth, Mahaboobkhan Rasool
  Immunological Investigations.2024; 53(2): 115.     CrossRef
• MHO or MUO? White adipose tissue remodeling
  Jing Yi Zhao, Li Juan Zhou, Kai Le Ma, Rui Hao, Min Li
  Obesity Reviews.2024;[Epub]     CrossRef
• Resistin in endocrine pancreas of sheep: Presence and expression related to different diets
  Margherita Maranesi, Elisa Palmioli, Cecilia Dall'Aglio, Daniele Marini, Polina Anipchenko, Elena De Felice, Paola Scocco, Francesca Mercati
  General and Comparative Endocrinology.2024; 348: 114452.     CrossRef
• Adipocytokines levels as potential biomarkers for discriminating patients with a diagnosis of depressive disorder from healthy controls
  Elżbieta Małujło-Balcerska, Tadeusz Pietras
  Journal of Psychiatric Research.2024; 171: 163.     CrossRef
• Adipokines in atopic dermatitis: the link between obesity and atopic dermatitis
  Shiyun Zhang, Bingjie Zhang, Yuehua Liu, Li Li
  Lipids in Health and Disease.2024;[Epub]     CrossRef
• The Role of Adipokines in the Control of Pituitary Functions
  Barbara Kaminska, Beata Kurowicka, Marta Kiezun, Kamil Dobrzyn, Katarzyna Kisielewska, Marlena Gudelska, Grzegorz Kopij, Karolina Szymanska, Barbara Zarzecka, Oguzhan Koker, Ewa Zaobidna, Nina Smolinska, Tadeusz Kaminski
  Animals.2024; 14(2): 353.     CrossRef
• Adipokine imbalance and its role in the pathogenesis of novel coronavirus infection
  I. D. Bespalova, U. M. Mitrichenko, V. V. Kalyuzhin, E. S. Koroleva, Yu. I. Koshchavtseva, D. S. Romanov, D. E. Pershina
  Bulletin of Siberian Medicine.2024; 22(4): 164.     CrossRef
• Association of adipokine levels with obesity in periodontal health and disease: A systematic review with meta‐analysis and meta‐regression
  Eswar Kandaswamy, Chun‐Teh Lee, Soumya Bardvalli Gururaj, Sachin Shivanaikar, Vinayak M. Joshi
  Journal of Periodontal Research.2024;[Epub]     CrossRef
• Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation
  David Ramiro-Cortijo, Pratibha Singh, Gloria Herranz Carrillo, Andrea Gila-Díaz, María A. Martín-Cabrejas, Camilia R. Martin, Silvia M. Arribas
  Frontiers in Endocrinology.2023;[Epub]     CrossRef
• Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus
  Branislava Rajkov, Marija Zdravković, Ana Ninić, Milica Brajković, Slobodan Klašnja, Vera Gardijan, Lidija Memon, Jelena Munjas, Marija Mihajlović, Vesna Spasojević- Kalimanovska, Vojislav Radosavljević, Miron Sopić
  Sleep and Breathing.2023; 27(5): 2031.     CrossRef
• Fat-to-heart crosstalk in health and disease
  Fleur Lodewijks, Timothy A. McKinsey, Emma L. Robinson
  Frontiers in Genetics.2023;[Epub]     CrossRef
• Adipokines as Diagnostic and Prognostic Markers for the Severity of COVID-19
  Thomas Grewal, Christa Buechler
  Biomedicines.2023; 11(5): 1302.     CrossRef
• Role of adipokines in sarcopenia
  Wenhao Lu, Wenjie Feng, Jieyu Lai, Dongliang Yuan, Wenfeng Xiao, Yusheng Li
  Chinese Medical Journal.2023; 136(15): 1794.     CrossRef
• Resistin, TNF-α, and microRNA 124-3p expressions in peripheral blood mononuclear cells are associated with diabetic nephropathy
  Amin Monjezi, Azam Khedri, Mehrnoosh Zakerkish, Ghorban Mohammadzadeh
  International Journal of Diabetes in Developing Countries.2022; 42(1): 62.     CrossRef
• Resistin in Urine and Breast Milk: Relation to Type of Feeding and Anthropometry at 1-Month
  Irena Santosa, Hiromichi Shoji, Kentaro Awata, Yoshiteru Arai, Hiroki Suganuma, Toshiaki Shimizu
  Pediatric Reports.2022; 14(1): 86.     CrossRef
• High Serum Levels of Resistin is Associated With Acute Cerebral Infarction
  Kee Ook Lee, Kyung-Yul Lee, Cheol-Young Lee, Ji Hoon Kim, Jaeku Kang, Hoi Young Lee, Sang-Jun Na, Seung-Hun Oh, Ji Hoe Heo
  The Neurologist.2022; 27(2): 41.     CrossRef
• Resistin production does not affect outcomes in a mouse model of acute surgical sepsis
  Anthony S. Bonavia, Zissis C. Chroneos, Victor Ruiz-Velasco, Charles H. Lang, Partha Mukhopadhyay
  PLOS ONE.2022; 17(3): e0265241.     CrossRef
• Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population
  Iman Akhlaghipour, Amir Reza Bina, Mohammad Reza Mogharrabi, Ali Fanoodi, Amir Reza Ebrahimian, Soroush Khojasteh Kaffash, Atefeh Babazadeh Baghan, Mohammad Erfan Khorashadizadeh, Negin Taghehchian, Meysam Moghbeli
  Human Genomics.2022;[Epub]     CrossRef
• Synergistic Effects of Weighted Genetic Risk Scores and Resistin and sST2 Levels on the Prognostication of Long-Term Outcomes in Patients with Coronary Artery Disease
  Hsin-Hua Chou, Lung-An Hsu, Jyh-Ming Jimmy Juang, Fu-Tien Chiang, Ming-Sheng Teng, Semon Wu, Yu-Lin Ko
  International Journal of Molecular Sciences.2022; 23(8): 4292.     CrossRef
• Hypoxia Increases the Potential for Neutrophil-mediated Endothelial Damage in Chronic Obstructive Pulmonary Disease
  Katharine M. Lodge, Arlette Vassallo, Bin Liu, Merete Long, Zhen Tong, Paul R. Newby, Danya Agha-Jaffar, Koralia Paschalaki, Clara E. Green, Kylie B. R. Belchamber, Victoria C. Ridger, Robert A. Stockley, Elizabeth Sapey, Charlotte Summers, Andrew S. Cowb
  American Journal of Respiratory and Critical Care Medicine.2022; 205(8): 903.     CrossRef
• The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer
  Klaudia Parafiniuk, Wiktoria Skiba, Anna Pawłowska, Dorota Suszczyk, Aleksandra Maciejczyk, Iwona Wertel
  Biomedicines.2022; 10(4): 920.     CrossRef
• Resistin Modulates Low-Density Lipoprotein Cholesterol Uptake in Human Placental Explants via PCSK9
  Sonia Nava-Salazar, Arturo Flores-Pliego, Giovanni Pérez-Martínez, Sandra Parra-Hernández, America Vanoye-Carlo, Francisco Ibarguengoitia-Ochoa, Otilia Perichart-Perera, Enrique Reyes-Muñoz, Juan Mario Solis-Paredes, Salvador Espino y Sosa, Guadalupe Estr
  Reproductive Sciences.2022; 29(11): 3242.     CrossRef
• Differential Association of Selected Adipocytokines, Adiponectin, Leptin, Resistin, Visfatin and Chemerin, with the Pathogenesis and Progression of Type 2 Diabetes Mellitus (T2DM) in the Asir Region of Saudi Arabia: A Case Control Study
  Mohammad Muzaffar Mir, Rashid Mir, Mushabab Ayed Abdullah Alghamdi, Javed Iqbal Wani, Zia Ul Sabah, Mohammed Jeelani, Vijaya Marakala, Shahzada Khalid Sohail, Mohamed O’haj, Muffarah Hamid Alharthi, Mohannad Mohammad S. Alamri
  Journal of Personalized Medicine.2022; 12(5): 735.     CrossRef
• Immune system and sarcopenia: Presented relationship and future perspective
  Xuzhi Zhang, Hengzhen Li, Miao He, Jingyu Wang, Yuxiang Wu, Yusheng Li
  Experimental Gerontology.2022; 164: 111823.     CrossRef
• Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes
  Giuseppina Biondi, Nicola Marrano, Anna Borrelli, Martina Rella, Giuseppe Palma, Isabella Calderoni, Edoardo Siciliano, Pasquale Lops, Francesco Giorgino, Annalisa Natalicchio
  International Journal of Molecular Sciences.2022; 23(10): 5522.     CrossRef
• Supplemental hydroxychloroquine therapy regulates adipokines in patients with systemic lupus erythematosus with stable disease
  Risa Wakiya, Kiyo Ueeda, Hiromi Shimada, Shusaku Nakashima, Tomohiro Kameda, Nobuyuki Miyatake, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Mao Mizusaki, Rina Mino, Norimitsu Kadowaki, Hiroaki Dobashi
  Clinical Rheumatology.2022; 41(11): 3345.     CrossRef
• Can soy isoflavones in combination with soy protein change serum concentration of adiponectin and resistin? A systematic review and meta‐analysis on randomized clinical trials
  Mitra Hariri, Bahareh Amirkalali, Ensiyeh Mollanoroozy, Ali Gholami
  Food Science & Nutrition.2022; 10(12): 4126.     CrossRef
• Adipokines: Deciphering the cardiovascular signature of adipose tissue
  Joseph C. Galley, Shubhnita Singh, Wanessa M.C. Awata, Juliano V. Alves, Thiago Bruder-Nascimento
  Biochemical Pharmacology.2022; 206: 115324.     CrossRef
• Evaluation of the Anti-Obesity Effect of Zeaxanthin and Exercise in HFD-Induced Obese Rats
  Mona Al-thepyani, Salha Algarni, Hana Gashlan, Mohamed Elzubier, Lina Baz
  Nutrients.2022; 14(23): 4944.     CrossRef
• Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial
  Jan Mieszkowski, Andżelika Borkowska, Błażej Stankiewicz, Andrzej Kochanowicz, Bartłomiej Niespodziński, Marcin Surmiak, Tomasz Waldziński, Rafał Rola, Miroslav Petr, Jędrzej Antosiewicz
  Nutrients.2021; 13(4): 1280.     CrossRef
• Resistin mitigates stemness and metabolic profile of human adipose-derived mesenchymal stem cells via insulin resistance
  Komal Rawal, Kishan M. Purohit, Tushar P. Patel, Neeta Karont, Sarita Gupta
  Cytokine.2021; 138: 155374.     CrossRef
• Resistin is co-secreted with adiponectin in white mouse adipocytes
  Saliha Musovic, Man Mohan Shrestha, Ali M. Komai, Charlotta S. Olofsson
  Biochemical and Biophysical Research Communications.2021; 534: 707.     CrossRef
• Resistin: Potential biomarker and therapeutic target in atherosclerosis
  Li Zhou, Jun-Yi Li, Ping-Ping He, Xiao-Hua Yu, Chao-Ke Tang
  Clinica Chimica Acta.2021; 512: 84.     CrossRef
• The circulating levels of CTRP1 and CTRP5 are associated with obesity indices and carotid intima-media thickness (cIMT) value in patients with type 2 diabetes: a preliminary study
  Ziba Majidi, Solaleh Emamgholipour, Abolfazl Omidifar, Soheil Rahmani Fard, Hossein Poustchi, Mehrnoosh Shanaki
  Diabetology & Metabolic Syndrome.2021;[Epub]     CrossRef
• Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation
  Chin-Chuan Chen, Chen-Hsin Kuo, Yann-Lii Leu, Shu-Huei Wang
  Pharmacological Research.2021; 164: 105291.     CrossRef
• A Focused Review of the Metabolic Side-Effects of Clozapine
  Jessica W. Y. Yuen, David D. Kim, Ric M. Procyshyn, William J. Panenka, William G. Honer, Alasdair M. Barr
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer’s Disease, the 5XFAD Mouse
  Antonio J. López-Gambero, Cristina Rosell-Valle, Dina Medina-Vera, Juan Antonio Navarro, Antonio Vargas, Patricia Rivera, Carlos Sanjuan, Fernando Rodríguez de Fonseca, Juan Suárez
  International Journal of Molecular Sciences.2021; 22(10): 5365.     CrossRef
• Resistin in pregnancy: Analysis of determinants in pairs of umbilical cord blood and maternal serum
  Anne Floeck, Nina Ferrari, Christine Joisten, Maria T. Puth, Brigitte Strizek, Ramona Dolscheid-Pommerich, Ulrich Gembruch, Waltraut M. Merz
  Cytokine: X.2021; 3(2): 100052.     CrossRef
• Is resistin the master link between inflammation and inflammation-related chronic diseases?
  Mohammed Taouis, Yacir Benomar
  Molecular and Cellular Endocrinology.2021; 533: 111341.     CrossRef
• The dynamics of human bone marrow adipose tissue in response to feeding and fasting
  Pouneh K. Fazeli, Miriam A. Bredella, Gisela Pachon-Peña, Wenxiu Zhao, Xun Zhang, Alexander T. Faje, Megi Resulaj, Sai P. Polineni, Tara M. Holmes, Hang Lee, Elizabeth K. O’Donnell, Ormond A. MacDougald, Mark C. Horowitz, Clifford J. Rosen, Anne Klibanski
  JCI Insight.2021;[Epub]     CrossRef
• Resistin: A journey from metabolism to cancer
  Ankita Deb, Bhavana Deshmukh, Pranay Ramteke, Firoz Khan Bhati, Manoj Kumar Bhat
  Translational Oncology.2021; 14(10): 101178.     CrossRef
• Obesity is the basis of metabolic syndrome
  A. F. Verbovoy, N. I. Verbovaya, Yu. A. Dolgikh
  Obesity and metabolism.2021; 18(2): 142.     CrossRef
• Human Milk Metabolic Hormones: Analytical Methods and Current Understanding
  Majed A. Suwaydi, Zoya Gridneva, Sharon L. Perrella, Mary E. Wlodek, Ching Tat Lai, Donna T. Geddes
  International Journal of Molecular Sciences.2021; 22(16): 8708.     CrossRef
• Adipokines as Immune Cell Modulators in Multiple Sclerosis
  Merel Rijnsburger, Niek Djuric, Inge A. Mulder, Helga E. de Vries
  International Journal of Molecular Sciences.2021; 22(19): 10845.     CrossRef
• The Role of Adipokines in Cardiovascular Pathology
  Valery Podzolkov , Anna Pokrovskaya, Ulyana Bazhanova , Tatyana Vargina , Svetlana Anatolievna Knyazeva , Daria Vanina
  Open Access Macedonian Journal of Medical Sciences.2021; 9(F): 794.     CrossRef
• Measurement of Plasma Resistin Concentrations in Horses with Metabolic and Inflammatory Disorders
  Beatriz Fuentes-Romero, Alberto Muñoz-Prieto, José J. Cerón, María Martín-Cuervo, Manuel Iglesias-García, Escolástico Aguilera-Tejero, Elisa Díez-Castro
  Animals.2021; 12(1): 77.     CrossRef
• EFFECT OF DIET AND EXERCISE-INDUCE WEIGHT LOSS ON LEVEL OF RESISTIN IN PATIENT WITH OBESITY
  О. I. Tokarenko, I. O. Andreieva, O. O. Tokarenko, M. M. Surmilo
  Modern medical technology.2021; (4): 11.     CrossRef
• Alteration of gut microbiota affects expression of adiponectin and resistin through modifying DNA methylation in high-fat diet-induced obese mice
  Hongyang Yao, Chaonan Fan, Yuanyuan Lu, Xiuqin Fan, Lulu Xia, Ping Li, Rui Wang, Tiantian Tang, Yuanyuan Wang, Kemin Qi
  Genes & Nutrition.2020;[Epub]     CrossRef
• Resistin hormone in diabetic kidney disease and its relation to iron status and hepcidin
  Zhian Sherzad Hayder, Zrar Saleem Kareem
  International Urology and Nephrology.2020; 52(4): 749.     CrossRef
• Proteoglycans in Obesity-Associated Metabolic Dysfunction and Meta-Inflammation
  Ariane R. Pessentheiner, G. Michelle Ducasa, Philip L. S. M. Gordts
  Frontiers in Immunology.2020;[Epub]     CrossRef
• Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies
  Andressa V. B. Nogueira, Marjan Nokhbehsaim, Sema Tekin, Rafael S. de Molon, Luis C. Spolidorio, Svenja Memmert, Anna Damanaki, Andreas Jäger, Sigrun Eick, James Deschner, Joni A. Cirelli
  Mediators of Inflammation.2020; 2020: 1.     CrossRef
• Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease
  Alan Chait, Laura J. den Hartigh
  Frontiers in Cardiovascular Medicine.2020;[Epub]     CrossRef
• The possible role of endocrine dysfunction of adipose tissue in gestational diabetes mellitus
  Patrik Šimják, Kateřina Anderlová, Anna Cinkajzlová, Antonín Pařízek, Michal Kršek, Martin Haluzík
  Minerva Endocrinologica.2020;[Epub]     CrossRef
• High Plasma Resistin Levels Portend the Insulin Resistance-Associated Susceptibility to Early Cognitive Decline in Patients with Type 2 Diabetes Mellitus
  Chenchen Wang, Xi Huang, Sai Tian, Rong Huang, Dan Guo, Hongyan Lin, Jiaqi Wang, Shaohua Wang
  Journal of Alzheimer's Disease.2020; 75(3): 807.     CrossRef
• Resistin in metabolism, inflammation, and disease
  Deeksha Tripathi, Sashi Kant, Saurabh Pandey, Nasreen Z. Ehtesham
  The FEBS Journal.2020; 287(15): 3141.     CrossRef
• Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases
  Lucia Recinella, Giustino Orlando, Claudio Ferrante, Annalisa Chiavaroli, Luigi Brunetti, Sheila Leone
  Frontiers in Physiology.2020;[Epub]     CrossRef
• Correlation of CCL18 with Levels of Adi-pokines in the Sera of Patients with Myocardial Infarction in a 6-Month Period: Case Series
  Atefeh GamarTalepoor, Ehsan Dowlatshahi, Mehrnoush Doroudchi
  Iranian South Medical Journal.2020; 23(3): 222.     CrossRef
• The Mesentery, Systemic Inflammation, and Crohn’s Disease
  Edgardo D Rivera, John Calvin Coffey, Dara Walsh, Eli D Ehrenpreis
  Inflammatory Bowel Diseases.2019; 25(2): 226.     CrossRef
• Resistin and adenylyl cyclase-associated protein 1 (CAP1) regulate the expression of genes related to insulin resistance in BNL CL.2 mouse liver cells
  Dimiter Avtanski, Karin Chen, Leonid Poretsky
  Data in Brief.2019; 25: 104112.     CrossRef
• Proteomic profile of patients with atrial fibrillation undergoing cardiac surgery†
  Ilias P Doulamis, George Samanidis, Aspasia Tzani, Asier Antoranz, Anastasios Gkogkos, Panagiotis Konstantopoulos, Vaia Pliaka, Angeliki Minia, Leonidas G Alexopoulos, Despina N Perrea, Konstantinos Perreas
  Interactive CardioVascular and Thoracic Surgery.2019; 28(1): 94.     CrossRef
• Angiotensin-(1-7), Adipokines and Inflammation
  Deborah de Farias Lelis, Daniela Fernanda de Freitas, Amanda Souto Machado, Thaísa Soares Crespo, Sérgio Henrique Sousa Santos
  Metabolism.2019; 95: 36.     CrossRef
• New Insights into Adipokines as Potential Biomarkers for Type-2 Diabetes Mellitus
  Marta Olivera-Santa Catalina, Pedro C. Redondo, Maria P. Granados, Carlos Cantonero, Jose Sanchez-Collado, Letizia Albarran, Jose J. Lopez
  Current Medicinal Chemistry.2019; 26(22): 4119.     CrossRef
• Myokine–adipokine cross-talk: potential mechanisms for the association between plasma irisin and adipokines and cardiometabolic risk factors in Mexican children with obesity and the metabolic syndrome
  Adrian M. Gonzalez-Gil, Mariana Peschard-Franco, Elena C. Castillo, Gustavo Gutierrez-DelBosque, Victor Treviño, Christian Silva-Platas, Luisa Perez-Villarreal, Gerardo Garcia-Rivas, Leticia Elizondo-Montemayor
  Diabetology & Metabolic Syndrome.2019;[Epub]     CrossRef
• Early Life Exposures to Perfluoroalkyl Substances in Relation to Adipokine Hormone Levels at Birth and During Childhood
  Colleen Shelly, Philippe Grandjean, Youssef Oulhote, Peter Plomgaard, Ruth Frikke-Schmidt, Flemming Nielsen, Denis Zmirou-Navier, Pal Weihe, Damaskini Valvi
  The Journal of Clinical Endocrinology & Metabolism.2019; 104(11): 5338.     CrossRef
• Overweight and obesity in childhood: Dietary, biochemical, inflammatory and lifestyle risk factors
  Samah R. Albataineh, Eman F. Badran, Reema F. Tayyem
  Obesity Medicine.2019; 15: 100112.     CrossRef
• Effects of major adipokines and the −420 C > G resistin gene polymorphism on the long-term outcome of patients with acute ischemic stroke
  Stella Bouziana, Konstantinos Tziomalos, Antonis Goulas, Timoleon-Achilleas Vyzantiadis, Maria Papadopoulou, Athanasia Panderi, Apostolos Ι. Ηatzitolios
  International Journal of Neuroscience.2019; 129(10): 978.     CrossRef
• The Complex Interactions Between Obesity, Metabolism and the Brain
  Romina María Uranga, Jeffrey Neil Keller
  Frontiers in Neuroscience.2019;[Epub]     CrossRef
• Resistin: A reappraisal
  E. Acquarone, F. Monacelli, R. Borghi, A. Nencioni, P. Odetti
  Mechanisms of Ageing and Development.2019; 178: 46.     CrossRef
• Implications of resistin in type 2 diabetes mellitus and coronary artery disease: Impairing insulin function and inducing pro‐inflammatory cytokines
  Melissa Emamalipour, Khaled Seidi, Ali Jahanban‐Esfahlan, Rana Jahanban‐Esfahlan
  Journal of Cellular Physiology.2019; 234(12): 21758.     CrossRef
• Serum-based soluble markers differentiate psoriatic arthritis from osteoarthritis
  Vinod Chandran, Fatima Abji, Anthony V Perruccio, Rajiv Gandhi, Suzanne Li, Richard J Cook, Dafna D Gladman
  Annals of the Rheumatic Diseases.2019; 78(6): 796.     CrossRef
• Telmisartan prevents diet-induced obesity and preserves leptin transport across the blood-brain barrier in high-fat diet-fed mice
  Franziska Schuster, Gianna Huber, Ines Stölting, Emily E. Wing, Kathrin Saar, Norbert Hübner, William A. Banks, Walter Raasch
  Pflügers Archiv - European Journal of Physiology.2018; 470(11): 1673.     CrossRef
• Adipokines in human breast milk
  Juergen Kratzsch, Yoon Ju Bae, Wieland Kiess
  Best Practice & Research Clinical Endocrinology & Metabolism.2018; 32(1): 27.     CrossRef
• Addressing the Perfect Storm: Biomarkers in Obesity and Pathophysiology of Cardiometabolic Risk
  Krasimira Aleksandrova, Dariush Mozaffarian, Tobias Pischon
  Clinical Chemistry.2018; 64(1): 142.     CrossRef
• Adipocytokine Involvement in Innate Immune Mechanisms
  Paulina Żelechowska, Elżbieta Kozłowska, Joanna Pastwińska, Justyna Agier, Ewa Brzezińska-Błaszczyk
  Journal of Interferon & Cytokine Research.2018; 38(12): 527.     CrossRef
• The effect of a garlic supplement on the pro-inflammatory adipocytokines, resistin and tumor necrosis factor-alpha, and on pain severity, in overweight or obese women with knee osteoarthritis
  Sahar Dehghani, Elham Alipoor, Ahmad Salimzadeh, Mehdi Yaseri, Mostafa Hosseini, Christine Feinle-Bisset, Mohammad Javad Hosseinzadeh-Attar
  Phytomedicine.2018; 48: 70.     CrossRef
• Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword
  Xiao-Yan Qi, Shun-Lin Qu, Wen-Hao Xiong, Oren Rom, Lin Chang, Zhi-Sheng Jiang
  Cardiovascular Diabetology.2018;[Epub]     CrossRef
• Usefulness of the Adipokines as Biomarkers of Ischemic Cardiac Dysfunction
  Larisa-Diana Mocan Hognogi, Cerasela-Mihaela Goidescu, Anca-Daniela Farcaş
  Disease Markers.2018; 2018: 1.     CrossRef
• Circulating fibroblast growth factor 21 in patients with liver cirrhosis
  Sabrina Krautbauer, Lisa Rein-Fischboeck, Elisabeth M Haberl, Rebekka Pohl, Reiner Wiest, Christa Buechler
  Clinical and Experimental Medicine.2018; 18(1): 63.     CrossRef
• Association of Cord Blood Resistin with Neonatal Birth Weight and Gestational Age
  Shahnaz Pourarian, Saeed Fotouhikia, Forough Saki
  Journal of Comprehensive Pediatrics.2018;[Epub]     CrossRef
• Major Adipokines and the −420C>G Resistin Gene Polymorphism as Predictors of Acute Ischemic Stroke Severity and In-Hospital Outcome
  Styliani D. Bouziana, Konstantinos Tziomalos, Antonios Goulas, Timoleon-Achilleas Vyzantiadis, Athanasia Panderi, Apostolos Ι. Ηatzitolios
  Journal of Stroke and Cerebrovascular Diseases.2018; 27(4): 963.     CrossRef
• Resistin and NGAL are associated with inflammatory response, endothelial activation and clinical outcomes in sepsis
  Stephen P. J. Macdonald, Erika Bosio, Claire Neil, Glenn Arendts, Sally Burrows, Lisa Smart, Simon G. A. Brown, Daniel M. Fatovich
  Inflammation Research.2017; 66(7): 611.     CrossRef
• Reference values for fasting serum resistin in healthy children and adolescents
  Ulrik Lausten-Thomsen, Michael Christiansen, Paula Louise Hedley, Tenna Ruest Haarmark Nielsen, Cilius Esmann Fonvig, Oluf Pedersen, Torben Hansen, Jens-Christian Holm
  Clinica Chimica Acta.2017; 469: 161.     CrossRef
• Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis
  Alexander Kalinkovich, Gregory Livshits
  Ageing Research Reviews.2017; 35: 200.     CrossRef
• Is There Any Relationship between Plasma 25-Hydroxyvitamin D3, Adipokine Profiles and Excessive Body Weight in Type 2 Diabetic Patients?
  Joanna Kocot, Piotr Dziemidok, Małgorzata Kiełczykowska, Jacek Kurzepa, Grzegorz Szcześniak, Irena Musik
  International Journal of Environmental Research and Public Health.2017; 15(1): 19.     CrossRef
• Exogenous Adipokine Peptide Resistin Protects Against Focal Cerebral Ischemia/Reperfusion Injury in Mice
  Jiangtao Zhu, Di Wu, Chenyu Zhao, Man Luo, Ronald C. Hamdy, Balvin H. L. Chua, Xingshun Xu, Zhigang Miao
  Neurochemical Research.2017; 42(10): 2949.     CrossRef
• Adipokines in Liver Cirrhosis
  Christa Buechler, Elisabeth Haberl, Lisa Rein-Fischboeck, Charalampos Aslanidis
  International Journal of Molecular Sciences.2017; 18(7): 1392.     CrossRef
• The role of sex steroids in white adipose tissue adipocyte function
  A E Newell-Fugate
  Reproduction.2017; 153(4): R133.     CrossRef
• Odanacatib Inhibits Resistin-induced Cardiomyocyte Hypertrophy Through the Inactivation of ERK Signaling Pathway
  Xian Zheng, Guanchang Cheng, Jianwei Luo, Qunhui Ye, Yongzhi Deng, Lin Wu
  International Journal of Pharmacology.2017; 13(2): 212.     CrossRef
• Linking resistin, inflammation, and cardiometabolic diseases
  Hyeong Kyu Park, Mi Kyung Kwak, Hye Jeong Kim, Rexford S. Ahima
  The Korean Journal of Internal Medicine.2017; 32(2): 239.     CrossRef
• Translating the biology of adipokines in atherosclerosis and cardiovascular diseases: Gaps and open questions
  M. Ruscica, A. Baragetti, A.L. Catapano, G.D. Norata
  Nutrition, Metabolism and Cardiovascular Diseases.2017; 27(5): 379.     CrossRef
• Differences in Mean Levels of Maternal Resistin Serum between Early Onset Preeclampsia (EOPE) and Late Onset Preeclampsia (LOPE)
  Yusrawati ., P. Alfajra, R. Machmud
  Research Journal of Obstetrics and Gynecology.2016; 10(1): 1.     CrossRef
• Secret talk between adipose tissue and central nervous system via secreted factors—an emerging frontier in the neurodegenerative research
  Avinash Parimisetty, Anne-Claire Dorsemans, Rana Awada, Palaniyandi Ravanan, Nicolas Diotel, Christian Lefebvre d’Hellencourt
  Journal of Neuroinflammation.2016;[Epub]     CrossRef
• The role of adipokines in ischemic stroke risk stratification
  Styliani Bouziana, Konstantinos Tziomalos, Antonios Goulas, Apostolos Ι Ηatzitolios
  International Journal of Stroke.2016; 11(4): 389.     CrossRef
• The endocrine function of human placenta: an overview
  Mariana A. Costa
  Reproductive BioMedicine Online.2016; 32(1): 14.     CrossRef
• Ursolic acid plays a protective role in obesity-induced cardiovascular diseases
  Yu-Ting Lin, Ya-Mei Yu, Weng-Cheng Chang, Su-Yin Chiang, Hsu-Chin Chan, Ming-Fen Lee
  Canadian Journal of Physiology and Pharmacology.2016; 94(6): 627.     CrossRef
• Determinants of body weight regulation in humans
  Milene Moehlecke, Luis Henrique Canani, Lucas Oliveira Junqueira e Silva, Manoel Roberto Maciel Trindade, Rogerio Friedman, Cristiane Bauermann Leitão
  Archives of Endocrinology and Metabolism.2016; 60(2): 152.     CrossRef
• Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats
  Tsung-Ming Lee, Wei-Ting Chen, Nen-Chung Chang
  Bioscience Reports.2016;[Epub]     CrossRef
• Les adipokines : état des lieux et nouveautés
  J.-P. Bastard, C. Bastard, S. Fellahi, C. Vatier, J. Capeau, B. Fève
  Obésité.2016; 11(3): 181.     CrossRef
• Factors that promote macrophage homing to adipose tissue in metabolic syndrome
  Ishwarlal Jialal, Beverley Adams-Huet, Sridevi Devaraj
  Journal of Diabetes and its Complications.2016; 30(8): 1434.     CrossRef
• Uncovering Factors Related to Pancreatic Beta-Cell Function
  Aoife M. Curran, Miriam F. Ryan, Elaine Drummond, Eileen R. Gibney, Michael J. Gibney, Helen M. Roche, Lorraine Brennan, Nigel Irwin
  PLOS ONE.2016; 11(8): e0161350.     CrossRef
• Resistin’s, obesity and insulin resistance: the continuing disconnect between rodents and humans
  X. Huang, Z. Yang
  Journal of Endocrinological Investigation.2016; 39(6): 607.     CrossRef
• Adipocytokines in renal transplant recipients
  Kristof Nagy, Shankar Prasad Nagaraju, Connie M. Rhee, Zoltan Mathe, Miklos Z. Molnar
  Clinical Kidney Journal.2016; 9(3): 359.     CrossRef
• Endocrine alterations from concentric vs. eccentric muscle actions: A brief review
  Robert R. Kraemer, V. Daniel Castracane
  Metabolism.2015; 64(2): 190.     CrossRef
• Non-traditional cytokines: How catecholamines and adipokines influence macrophages in immunity, metabolism and the central nervous system
  Mark A. Barnes, Monica J. Carson, Meera G. Nair
  Cytokine.2015; 72(2): 210.     CrossRef
• Local and serum levels of adipokines in patients with obesity after periodontal therapy: one‐year follow‐up
  Tiago Eduardo Dias Gonçalves, Glaucia Santos Zimmermann, Luciene Cristina Figueiredo, Monique de Carvalho Souza, Daniele Ferreira da Cruz, Marta Ferreira Bastos, Hélio Doyle Pereira da Silva, Poliana Mendes Duarte
  Journal of Clinical Periodontology.2015; 42(5): 431.     CrossRef
• Newborn Adipokines and Birth Outcomes
  Edwina H. Yeung, Alexander C. McLain, Nancy Anderson, David Lawrence, Nansi S. Boghossian, Charlotte Druschel, Erin Bell
  Paediatric and Perinatal Epidemiology.2015; 29(4): 317.     CrossRef
• The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats
  Márta Sárközy, Gergő Szűcs, Márton Pipicz, Ágnes Zvara, Katalin Éder, Veronika Fekete, Csilla Szűcs, Judit Bárkányi, Csaba Csonka, László G. Puskás, Csaba Kónya, Péter Ferdinandy, Tamás Csont
  Cardiovascular Diabetology.2015;[Epub]     CrossRef
• Diet-induced variability of the resistin gene (Retn) transcript level and methylation profile in rats
  Joanna Nowacka-Woszuk, Ewa Pruszynska-Oszmalek, Maciej Szydlowski, Slawomir Sadkowski, Izabela Szczerbal
  BMC Genetics.2015;[Epub]     CrossRef
• INFLUENCE OF RESISTIN ON THE COURSE OF ISCHEMIC HEART DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
  A. T. Teplyakov, Sh. D. Akhmedov, T. Ye. Suslova, А. V. Andriyanova, A. V. Kuznetsova, N. V. Protopopova, V. V. Kalyuzhin, O. N. Nasanova
  Bulletin of Siberian Medicine.2015; 14(5): 73.     CrossRef
• The Effects of a Single Developmentally Entrained Pulse of Testosterone in Female Neonatal Mice on Reproductive and Metabolic Functions in Adult Life
  Hyeran Jang, Shalender Bhasin, Tyler Guarneri, Carlo Serra, Mary Schneider, Mi-Jeong Lee, Wen Guo, Susan K. Fried, Karol Pencina, Ravi Jasuja
  Endocrinology.2015; 156(10): 3737.     CrossRef
• The Resin fromProtium heptaphyllumPrevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms
  Karine Maria Martins Bezerra Carvalho, José Delano Barreto Marinho Filho, Tiago Sousa de Melo, Ana Jérsia Araújo, Josiane da Silva Quetz, Maria do Perpétuo Socorro Saldanha da Cunha, Karina Moura de Melo, Armenio Andre de Carvalho Almeida da Silva, Adrian
  Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
• Evolution of the Vertebrate Resistin Gene Family
  Qingda Hu, Huanran Tan, David M. Irwin, Marc Robinson-Rechavi
  PLOS ONE.2015; 10(6): e0130188.     CrossRef
• Obesity, adipokines and neuroinflammation
  Argel Aguilar-Valles, Wataru Inoue, Christoph Rummel, Giamal N. Luheshi
  Neuropharmacology.2015; 96: 124.     CrossRef
• Adipokines at the crossroad between obesity and cardiovascular disease
  Filippo Molica, Sandrine Morel, Brenda Kwak, Françoise Rohner-Jeanrenaud, Sabine Steffens
  Thrombosis and Haemostasis.2015; 113(03): 553.     CrossRef
• Resistin – 420 C/G polymorphism and serum resistin level in Iranian patients with gestational diabetes mellitus
  Mohammad Ali Takhshid, Zinab Zare
  Journal of Diabetes & Metabolic Disorders.2015;[Epub]     CrossRef
• Ictal adipokines are associated with pain severity and treatment response in episodic migraine
  Nu Cindy Chai, Bizu Gelaye, Gretchen E. Tietjen, Paul D. Dash, Barbara A. Gower, Linda W. White, Thomas N. Ward, Ann I. Scher, B. Lee Peterlin
  Neurology.2015; 84(14): 1409.     CrossRef
• Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration
  Lindsay J. Spielman, Jonathan P. Little, Andis Klegeris
  Journal of Neuroimmunology.2014; 273(1-2): 8.     CrossRef
• Wild Blueberries (Vaccinium myrtillus) Alleviate Inflammation and Hypertension Associated with Developing Obesity in Mice Fed with a High-Fat Diet
  Otto T. Mykkänen, Anne Huotari, Karl-Heinz Herzig, Thomas W. Dunlop, Hannu Mykkänen, Pirkka V. Kirjavainen, Michael Müller
  PLoS ONE.2014; 9(12): e114790.     CrossRef
• Role of fat and adipokines in intestinal inflammation
  LeaI Kredel, Arvind Batra, Britta Siegmund
  Current Opinion in Gastroenterology.2014; 30(6): 559.     CrossRef
• 13C metabolic flux analysis shows that resistin impairs the metabolic response to insulin in L6E9 myotubes
  Shirley Guzmán, Silvia Marin, Anibal Miranda, Vitaly A Selivanov, Josep J Centelles, Romain Harmancey, Fatima Smih, Annie Turkieh, Yves Durocher, Antonio Zorzano, Philippe Rouet, Marta Cascante
  BMC Systems Biology.2014;[Epub]     CrossRef
• Bee Pollen Improves Muscle Protein and Energy Metabolism in Malnourished Old Rats through Interfering with the Mtor Signaling Pathway and Mitochondrial Activity
  Jérôme Salles, Nicolas Cardinault, Véronique Patrac, Alexandre Berry, Christophe Giraudet, Marie-Laure Collin, Audrey Chanet, Camille Tagliaferri, Philippe Denis, Corinne Pouyet, Yves Boirie, Stéphane Walrand
  Nutrients.2014; 6(12): 5500.     CrossRef

Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in endocrine and metabolic functions which are the underlying causes of the metabolic syndrome. Many adipokines, hormones secreted by adipose tissue, regulate cells from the immune system. Interestingly, most of these adipokines are proinflammatory mediators, which increase dramatically in the obese state and are believed to be involved in the pathogenesis of insulin resistance. Drugs that target peroxisome proliferator-activated receptor-γ have been shown to possess anti-inflammatory effects in animal models of diabetes. These findings, and the link between inflammation and the metabolic syndrome, will be reviewed here.

Citations

Citations to this article as recorded by  

• Lysine 222 in PPAR γ1 functions as the key site of MuRF2-mediated ubiquitination modification
  Yucheng Fan, Fangjing Xu, Rui Wang, Jun He
  Scientific Reports.2023;[Epub]     CrossRef
• Heart failure and diabetes: Clinical significance and epidemiology of this two‐way association
  Terri Jerkins, Janet B. McGill, David S. H. Bell
  Diabetes, Obesity and Metabolism.2023; 25(S3): 3.     CrossRef
• The pleiotropic peroxisome proliferator activated receptors: Regulation and therapeutics
  Gargi Dixit, Arati Prabhu
  Experimental and Molecular Pathology.2022; 124: 104723.     CrossRef
• The Effect of PPARγ rs1801282 Variant on Mortality Risk Among Asians With Chronic Kidney Disease: A Cohort Study and Meta-Analysis
  Wei-Teing Chen, Chih-Chien Chiu, Dung-Jang Tsai, Pi-Shao Ko, Meng-Chang Lee, Hsiao-Ting Lin, Ying-Kai Chen, Wen Su, Yuh-Feng Lin, Sui-Lung Su
  Frontiers in Genetics.2022;[Epub]     CrossRef
• Metabolic Spectrum of Liver Failure in Type 2 Diabetes and Obesity: From NAFLD to NASH to HCC
  Hyunmi Kim, Da Som Lee, Tae Hyeon An, Hyun-Ju Park, Won Kon Kim, Kwang-Hee Bae, Kyoung-Jin Oh
  International Journal of Molecular Sciences.2021; 22(9): 4495.     CrossRef
• Associations between obesity-related gene expression in maternal and cord blood and newborn adiposity: findings from the Araraquara Cohort study
  P. Nakandakare, C. F. Nicoletti, N. Y. Noronha, C. B. Nonino, P. P. Argentato, N. N. Dejani, L. A. Luzia, M. M. Rogero, P. H. C. Rondó
  International Journal of Obesity.2021; 45(9): 1958.     CrossRef
• PPARG Pro12Ala Polymorphism with CKD in Asians: A Meta-Analysis Combined with a Case-Control Study—A Key for Reaching Null Association
  Hsiang-Cheng Chen, Wei-Teing Chen, Tzu-Ling Sung, Dung-Jang Tsai, Chin Lin, Hao Su, Yuh-Feng Lin, Hung-Yi Chiu, Sui-Lung Su
  Genes.2020; 11(6): 705.     CrossRef
• Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf
  Mebrahtom Gebrelibanos Hiben, Laura de Haan, Bert Spenkelink, Sebastiaan Wesseling, Jacques Vervoort, Ivonne M. C. M. Rietjens
  BMC Complementary Medicine and Therapies.2020;[Epub]     CrossRef
• UPR modulation of host immunity by Pseudomonas aeruginosa in cystic fibrosis
  Brahmchetna Bedi, Kuo-Chuan. Lin, Nicholas M. Maurice, Zhihong Yuan, Kaiser Bijli, Michael Koval, C. Michael Hart, Joanna B. Goldberg, Arlene Stecenko, Ruxana T. Sadikot
  Clinical Science.2020; 134(14): 1911.     CrossRef
• Sepsis Immunometabolism: From Defining Sepsis to Understanding How Energy Production Affects Immune Response
  Ioannis Koutroulis, Rachael Batabyal, Brittany McNamara, Matthew Ledda, Claire Hoptay, Robert J. Freishtat
  Critical Care Explorations.2019; 1(11): e0061.     CrossRef
• Combining SGLT2 Inhibition With a Thiazolidinedione Additively Attenuate the Very Early Phase of Diabetic Nephropathy Progression in Type 2 Diabetes Mellitus
  Eugene Han, Eugene Shin, Gyuri Kim, Ji-Yeon Lee, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha
  Frontiers in Endocrinology.2018;[Epub]     CrossRef
• Role of oral hypoglycemic drugs on inflammatory condition associated with type 2 diabetes mellitus
  Shamim Shaikh Mohiuddin
  Journal of Diabetes, Metabolic Disorders & Control.2018; 5(2): 78.     CrossRef
• Effects of lobeglitazone on insulin resistance and hepatic steatosis in high-fat diet-fed mice
  Bong-Hoi Choi, Zhen Jin, Chin-ok Yi, Juhong Oh, Eun Ae Jeong, Jong Youl Lee, Kyung-ah Park, Kyung Eun Kim, Jung Eun Lee, Hyun-Jin Kim, Jong Ryeal Hahm, Gu Seob Roh, Jonathan M Peterson
  PLOS ONE.2018; 13(7): e0200336.     CrossRef
• Cucurbita ficifolia (Cucurbitaceae) modulates inflammatory cytokines and IFN-γ in obese mice
  Á. Fortis-Barrera, R. García-Macedo, J.C. Almanza-Perez, G. Blancas-Flores, A. Zamilpa-Alvarez, J.L. Flores-Sáenz, M. Cruz, R. Román-Ramos, F.J. Alarcón-Aguilar
  Canadian Journal of Physiology and Pharmacology.2017; 95(2): 170.     CrossRef
• Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness
  Yong-ho Lee, Jae Hyeon Kim, So Ra Kim, Heung Yong Jin, Eun-Jung Rhee, Young Min Cho, Byung-Wan Lee
  Journal of Korean Medical Science.2017; 32(1): 60.     CrossRef
• Peroxisome proliferator‐activated receptor‐γ agonists attenuate biofilm formation by Pseudomonas aeruginosa
  Brahmchetna Bedi, Nicholas M. Maurice, Vincent T. Ciavatta, K. Sabrina Lynn, Zhihong Yuan, Samuel A. Molina, Myungsoo Joo, William R. Tyor, Joanna B. Goldberg, Michael Koval, C. Michael Hart, Ruxana T. Sadikot
  The FASEB Journal.2017; 31(8): 3608.     CrossRef
• Pioglitazone and the secondary prevention of cardiovascular disease. A meta-analysis of randomized-controlled trials
  Marit de Jong, H. Bart van der Worp, Yolanda van der Graaf, Frank L. J. Visseren, Jan Westerink
  Cardiovascular Diabetology.2017;[Epub]     CrossRef
• Gestational diabetes mellitus was related to ambient air pollutant nitric oxide during early gestation
  Shih-Chun Pan, Ching-Chun Huang, Shio-Jean Lin, Bing-Yu Chen, Chang-Chuan Chan, Yue-Liang Leon Guo
  Environmental Research.2017; 158: 318.     CrossRef
• The Multifaceted Haptoglobin in the Context of Adipose Tissue and Metabolism
  Margherita Maffei, Ilaria Barone, Gaia Scabia, Ferruccio Santini
  Endocrine Reviews.2016; 37(4): 403.     CrossRef
• Enhanced Clearance of Pseudomonas aeruginosa by Peroxisome Proliferator-Activated Receptor Gamma
  Brahmchetna Bedi, Zhihong Yuan, Myungsoo Joo, Susu M. Zughaier, Joanna B. Goldberg, Jack L. Arbiser, C. Michael Hart, Ruxana T. Sadikot, B. A. McCormick
  Infection and Immunity.2016; 84(7): 1975.     CrossRef
• F-box only protein 9 is an E3 ubiquitin ligase of PPARγ
  Kyeong Won Lee, Soo Heon Kwak, Young Do Koo, Yun-Kyung Cho, Hak Mo Lee, Hye Seung Jung, Young Min Cho, Young Joo Park, Sung Soo Chung, Kyong Soo Park
  Experimental & Molecular Medicine.2016; 48(5): e234.     CrossRef
• The Resin fromProtium heptaphyllumPrevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms
  Karine Maria Martins Bezerra Carvalho, José Delano Barreto Marinho Filho, Tiago Sousa de Melo, Ana Jérsia Araújo, Josiane da Silva Quetz, Maria do Perpétuo Socorro Saldanha da Cunha, Karina Moura de Melo, Armenio Andre de Carvalho Almeida da Silva, Adrian
  Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
• Lobeglitazone and pioglitazone as add‐ons to metformin for patients with type 2 diabetes: a 24‐week, multicentre, randomized, double‐blind, parallel‐group, active‐controlled, phase III clinical trial with a 28‐week extension
  S.‐M. Jin, C.‐Y. Park, Y. M. Cho, B. J. Ku, C. W. Ahn, B.‐S. Cha, K. W. Min, Y. A. Sung, S. H. Baik, K. W. Lee, K.‐H. Yoon, M.‐K. Lee, S. W. Park
  Diabetes, Obesity and Metabolism.2015; 17(6): 599.     CrossRef
• Deconvolution of Complex 1D NMR Spectra Using Objective Model Selection
  Travis S. Hughes, Henry D. Wilson, Ian Mitchelle S. de Vera, Douglas J. Kojetin, Paul C. Driscoll
  PLOS ONE.2015; 10(8): e0134474.     CrossRef
• PPARγ partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes
  Flora Aparecida Milton, Aleksandra Cvoro, Angelica A. Amato, Douglas H. Sieglaff, Carly S. Filgueira, Anithachristy Sigamani Arumanayagam, Maria do Carmo Alves de Lima, Ivan Rocha Pitta, Francisco de Assis Rocha Neves, Paul Webb
  Biochemical and Biophysical Research Communications.2015; 464(3): 718.     CrossRef
• Voluntary exercise prevents colonic inflammation in high-fat diet-induced obese mice by up-regulating PPAR-γ activity
  Wei-Xin Liu, Ting Wang, Feng Zhou, Ying Wang, Jun-Wei Xing, Shen Zhang, Shou-Zhi Gu, Li-Xuan Sang, Cong Dai, Hai-Lan Wang
  Biochemical and Biophysical Research Communications.2015; 459(3): 475.     CrossRef
• Effect of a new PPAR-gamma agonist, lobeglitazone, on neointimal formation after balloon injury in rats and the development of atherosclerosis
  Soo Lim, Kuy-Sook Lee, Jie Eun Lee, Ho Seon Park, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Kyong Soo Park, Young Bum Kim, Hak Chul Jang
  Atherosclerosis.2015; 243(1): 107.     CrossRef
• Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control
  A.J. Scheen, N. Esser, N. Paquot
  Diabetes & Metabolism.2015; 41(3): 183.     CrossRef
• Genomic binding and regulation of gene expression by the thyroid carcinoma-associated PAX8-PPARG fusion protein
  Yanxiao Zhang, Jingcheng Yu, Chee Lee, Bin Xu, Maureen A. Sartor, Ronald J. Koenig
  Oncotarget.2015; 6(38): 40418.     CrossRef
• Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Ligand Choreography: Newcomers Take the Stage
  Santiago Garcia-Vallvé, Laura Guasch, Sarah Tomas-Hernández, Josep Maria del Bas, Vincent Ollendorff, Lluís Arola, Gerard Pujadas, Miquel Mulero
  Journal of Medicinal Chemistry.2015; 58(14): 5381.     CrossRef
• Pathway Analysis of Metabolic Syndrome Using a Genome-Wide Association Study of Korea Associated Resource (KARE) Cohorts
  Unjin Shim, Han-Na Kim, Yeon-Ah Sung, Hyung-Lae Kim
  Genomics & Informatics.2014; 12(4): 195.     CrossRef
• Pax-8–PPAR-γ fusion protein in thyroid carcinoma
  Priyadarshini Raman, Ronald J. Koenig
  Nature Reviews Endocrinology.2014; 10(10): 616.     CrossRef
• Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients: a systemic review and meta-analysis
  Shinan Yin, Hua Bai, Danqing Jing
  Diagnostic Pathology.2014;[Epub]     CrossRef
• Common biological mechanisms between bipolar disorder and type 2 diabetes: Focus on inflammation
  Ajaykumar N. Sharma, Isabelle E. Bauer, Marsal Sanches, Juan F. Galvez, Giovana B. Zunta-Soares, Joao Quevedo, Flavio Kapczinski, Jair C. Soares
  Progress in Neuro-Psychopharmacology and Biological Psychiatry.2014; 54: 289.     CrossRef

Numerous studies have established a link between autophagy and aging; however, the relationship has not been clearly defined. Aging is a very complex process caused by the accumulation of various factors due to the gradual failure of cellular maintenance. Recent studies have shown that autophagy reduces the stress responses induced by starvation, reactive oxygen species, and the accumulation of intracellular proteins and organelles through cytoprotection, clearance of damaged mitochondria, and lysosomal degradation. Here, we summarize our current understanding of the relationship between autophagy and the aging process.

Citations

Citations to this article as recorded by  

• Dysregulation of autophagy activation induced by atorvastatin contributes to new-onset diabetes mellitus in western diet-fed mice
  Juhee Kim, Minjune Kim, Minjeong Kim, Young-Hye You, Youngmi Song, Byung-Wan Lee
  Metabolism.2024; 153: 155795.     CrossRef
• The impact of zinc on the molecular signaling pathways in the diabetes disease
  Keyvan Asghari, Zahra Shargh, Sina Fatehfar, Leila Chodari, Parsa Sameei
  Journal of Trace Elements in Medicine and Biology.2022; 72: 126985.     CrossRef
• Antiaging agents: safe interventions to slow aging and healthy life span extension
  Ji-Kai Liu
  Natural Products and Bioprospecting.2022;[Epub]     CrossRef
• Glycans in autophagy, endocytosis and lysosomal functions
  Fulvio Reggiori, Hans-Joachim Gabius, Massimo Aureli, Winfried Römer, Sandro Sonnino, Eeva-Liisa Eskelinen
  Glycoconjugate Journal.2021; 38(5): 625.     CrossRef
• Reduced cardiomyocyte Na+ current in the age‐dependent murine Pgc‐1β−/− model of ventricular arrhythmia
  Shiraz Ahmad, Haseeb Valli, Robert Smyth, Anita Y. Jiang, Kamalan Jeevaratnam, Hugh R. Matthews, Christopher L.‐H. Huang
  Journal of Cellular Physiology.2019; 234(4): 3921.     CrossRef
• Autophagy in Human Health and Disease: Novel Therapeutic Opportunities
  Francesca Giampieri, Sadia Afrin, Tamara Y. Forbes-Hernandez, Massimiliano Gasparrini, Danila Cianciosi, Patricia Reboredo-Rodriguez, Alfonso Varela-Lopez, Jose L. Quiles, Maurizio Battino
  Antioxidants & Redox Signaling.2019; 30(4): 577.     CrossRef
• Molybdenum Disulfide Nanoparticles Resist Oxidative Stress-Mediated Impairment of Autophagic Flux and Mitigate Endothelial Cell Senescence and Angiogenic Dysfunctions
  Sunkui Ke, Youlin Lai, Tong Zhou, Lihuang Li, Yange Wang, Lei Ren, Shefang Ye
  ACS Biomaterials Science & Engineering.2018; 4(2): 663.     CrossRef
• Phenformin inhibits cell proliferation and induces cell apoptosis and autophagy in cholangiocarcinoma
  Shuyang Hu, Qing Ouyang, Qingbao Cheng, Jinghan Wang, Feiling Feng, Liang Qiao, Wei Gan, Yang Shi, Demin Wu, Xiaoqing Jiang
  Molecular Medicine Reports.2018;[Epub]     CrossRef
• Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β) murine hearts
  Shiraz Ahmad, Haseeb Valli, Karan R. Chadda, James Cranley, Kamalan Jeevaratnam, Christopher L.-H. Huang
  Mechanisms of Ageing and Development.2018; 173: 92.     CrossRef
• From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home
  Margaret M. Harnett, Miguel A. Pineda, Perle Latré de Laté, Russell J. Eason, Sébastien Besteiro, William Harnett, Gordon Langsley
  Biomedical Journal.2017; 40(1): 9.     CrossRef
• Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53
  Young Song, Woo Lee, Yong-ho Lee, Eun Kang, Bong-Soo Cha, Byung-Wan Lee
  International Journal of Molecular Sciences.2016; 17(1): 122.     CrossRef
• Selected reaction monitoring mass spectrometry for relative quantification of proteins involved in cellular life and death processes
  Rune Isak Dupont Birkler, Zahra Nochi, Niels Gregersen, Johan Palmfeldt
  Journal of Chromatography B.2016; 1035: 49.     CrossRef
• Dehydroepiandrosterone prevents linoleic acid-induced endothelial cell senescence by increasing autophagy
  Min Jung Lee, Eun Hee Kim, Sang Ah. Lee, Yu Mi Kang, Chang Hee Jung, Hae Kyeong Yoon, So Mi Seol, Yoo La Lee, Woo Je Lee, Joong-Yeol Park
  Metabolism.2015; 64(9): 1134.     CrossRef
• Successful aging: Advancing the science of physical independence in older adults
  Stephen D. Anton, Adam J. Woods, Tetso Ashizawa, Diana Barb, Thomas W. Buford, Christy S. Carter, David J. Clark, Ronald A. Cohen, Duane B. Corbett, Yenisel Cruz-Almeida, Vonetta Dotson, Natalie Ebner, Philip A. Efron, Roger B. Fillingim, Thomas C. Foster
  Ageing Research Reviews.2015; 24: 304.     CrossRef
• Autophagy in acute leukemias: A double-edged sword with important therapeutic implications
  Cecilia Evangelisti, Camilla Evangelisti, Francesca Chiarini, Annalisa Lonetti, Francesca Buontempo, Luca M. Neri, James A. McCubrey, Alberto M. Martelli
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2015; 1853(1): 14.     CrossRef
• Autophagy: A housekeeper in cardiorenal metabolic health and disease
  Guanghong Jia, James R. Sowers
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2015; 1852(2): 219.     CrossRef
• Autophagy and Lipid Droplets in the Liver
  Nuria Martinez-Lopez, Rajat Singh
  Annual Review of Nutrition.2015; 35(1): 215.     CrossRef
• Lysosomal Two-pore Channel Subtype 2 (TPC2) Regulates Skeletal Muscle Autophagic Signaling
  Pei-Hui Lin, Pu Duann, Shinji Komazaki, Ki Ho Park, Haichang Li, Mingzhai Sun, Mathew Sermersheim, Kristyn Gumpper, John Parrington, Antony Galione, A. Mark Evans, Michael X. Zhu, Jianjie Ma
  Journal of Biological Chemistry.2015; 290(6): 3377.     CrossRef
• Zinc and autophagy
  Juan P. Liuzzi, Liang Guo, Changwon Yoo, Tiffanie S. Stewart
  BioMetals.2014; 27(6): 1087.     CrossRef
• Autophagy in the eye: Implications for ocular cell health
  Laura S. Frost, Claire H. Mitchell, Kathleen Boesze-Battaglia
  Experimental Eye Research.2014; 124: 56.     CrossRef
• Can Enhanced Autophagy Be Associated with Human Longevity? Serum Levels of the Autophagy Biomarker Beclin-1 Are Increased in Healthy Centenarians
  Enzo Emanuele, Piercarlo Minoretti, Fabian Sanchis-Gomar, Helios Pareja-Galeano, Yusuf Yilmaz, Nuria Garatachea, Alejandro Lucia
  Rejuvenation Research.2014; 17(6): 518.     CrossRef
• Responses and adaptations of intervertebral disc cells to microenvironmental stress: a possible central role of autophagy in the adaptive mechanism
  Libo Jiang, Fenglai Yuan, Xiaofan Yin, Jian Dong
  Connective Tissue Research.2014; 55(5-6): 311.     CrossRef
• STOP accelerating lung aging for the treatment of COPD
  Kazuhiro Ito, Nicolas Mercado
  Experimental Gerontology.2014; 59: 21.     CrossRef
• In search of antiaging modalities: Evaluation of mTOR‐ and ROS/DNA damage‐signaling by cytometry
  Zbigniew Darzynkiewicz, Hong Zhao, H. Dorota Halicka, Jiangwei Li, Yong‐Syu Lee, Tze‐Chen Hsieh, Joseph M. Wu
  Cytometry Part A.2014; 85(5): 386.     CrossRef
• Induction of Covalently Crosslinked p62 Oligomers with Reduced Binding to Polyubiquitinated Proteins by the Autophagy Inhibitor Verteporfin
  Elizabeth Donohue, Aruna D. Balgi, Masaaki Komatsu, Michel Roberge, Srinivasa M. Srinivasula
  PLoS ONE.2014; 9(12): e114964.     CrossRef

Although glucose-lowering treatment shows some risk lowering effects in cardiovascular diseases, risks of macrovascular and microvascular complications have still remained, and development of new therapeutic strategies is needed. Recent data have shown that peroxisome proliferator activated receptor-α (PPAR-α) plays a pivotal role in the regulation of lipid homeostasis, fatty acid oxidation, cellular differentiation, and immune response such as inflammation or vascularization related to diabetic complication. This review will re-examine the metabolic role of PPAR-α, summarize data from clinical studies on the effect of PPAR-α agonist in diabetes, and will discuss the possible therapeutic role of PPAR-α activation.

Citations

Citations to this article as recorded by  

• Recent Insights into the Etiopathogenesis of Diabetic Retinopathy and Its Management
  Arpon Biswas, Abhijit Deb Choudhury, Sristi Agrawal, Amol Chhatrapati Bisen, Sachin Nashik Sanap, Sarvesh Kumar Verma, Mukesh Kumar, Anjali Mishra, Shivansh Kumar, Mridula Chauhan, Rabi Sankar Bhatta
  Journal of Ocular Pharmacology and Therapeutics.2024; 40(1): 13.     CrossRef
• Counteracting health risks by Modulating Homeostatic Signaling
  Junqiang J. Tian, Mark Levy, Xuekai Zhang, Robert Sinnott, Rolando Maddela
  Pharmacological Research.2022; 182: 106281.     CrossRef
• Moringa oleifera leaf extract influences oxidative metabolism in C2C12 myotubes through SIRT1-PPARα pathway
  Guglielmo Duranti, Mariateresa Maldini, Domenico Crognale, Stefania Sabatini, Federica Corana, Katy Horner, Roberta Ceci
  Phytomedicine Plus.2021; 1(1): 100014.     CrossRef
• Diabetes risk associated with plasma epoxylipid levels
  John D. Imig
  eBioMedicine.2021; 66: 103331.     CrossRef
• Genome-Wide Characterization of Alternative Splicing Events and Their Responses to Cold Stress in Tilapia
  Bi Jun Li, Zong Xian Zhu, Hui Qin, Zi Ning Meng, Hao Ran Lin, Jun Hong Xia
  Frontiers in Genetics.2020;[Epub]     CrossRef
• PPARγ provides anti-inflammatory and protective effects in intrahepatic cholestasis of pregnancy through NF-κB pathway
  Yan Zhang, Xiaoping Huang, Jie Zhou, Yongxiang Yin, Ting Zhang, Daozhen Chen
  Biochemical and Biophysical Research Communications.2018; 504(4): 834.     CrossRef
• Fermented Ginseng Contains an Agonist of Peroxisome Proliferator Activated Receptors α and γ
  Kentaro Igami, Yosuke Shimojo, Hisatomi Ito, Toshitsugu Miyazaki, Fusako Nakano, Yoshiki Kashiwada
  Journal of Medicinal Food.2016; 19(9): 817.     CrossRef
• Long-term oral administration of osteocalcin induces insulin resistance in male mice fed a high-fat, high-sucrose diet
  Yu Yasutake, Akiko Mizokami, Tomoyo Kawakubo-Yasukochi, Sakura Chishaki, Ichiro Takahashi, Hiroshi Takeuchi, Masato Hirata
  American Journal of Physiology-Endocrinology and Metabolism.2016; 310(8): E662.     CrossRef
• Peroxisome Proliferator-Activated Receptor-γGene Expression and Its Association with Oxidative Stress in Patients with Metabolic Syndrome
  Mehdi Hatami, Massoud Saidijam, Reza Yadegarzari, Shiva Borzuei, Alireza Soltanian, Marzieh Safi Arian, Mohammad Taghi Goodarzi
  Chonnam Medical Journal.2016; 52(3): 201.     CrossRef
• Short Exposure to a High-Sucrose Diet and the First ‘Hit' of Nonalcoholic Fatty Liver Disease in Mice
  Flavia Fernandes-Lima, Thiago Luís Ribeiro Gomes Monte, Fernanda Amorim de Morais Nascimento, Bianca Martins Gregório
  Cells Tissues Organs.2016; 201(6): 464.     CrossRef
• In vitro evaluation of dual agonists for PPARγ/β from the flower of Edgeworthia gardneri (wall.) Meisn
  Die Gao, Yong-lan Zhang, Pan Xu, Ye-xin Lin, Feng-qing Yang, Jian-hui Liu, Hai-wen Zhu, Zhi-ning Xia
  Journal of Ethnopharmacology.2015; 162: 14.     CrossRef
• PPARα Agonist Fenofibrate Ameliorates Learning and Memory Deficits in Rats Following Global Cerebral Ischemia
  Ai-Guo Xuan, Yan Chen, Da-Hong Long, Meng Zhang, Wei-Dong Ji, Wen-Juan Zhang, Ji-Hong Liu, Le-Peng Hong, Xiao-Song He, Wen-Liang Chen
  Molecular Neurobiology.2015; 52(1): 601.     CrossRef
• Modulation of Cardiac Connexin-43 by Omega-3 Fatty Acid Ethyl-Ester Supplementation Demonstrated in Spontaneously Diabetic Rats
  J. RADOSINSKA, L. H. KURAHARA, K. HIRAISHI, C. VICZENCZOVA, T. EGAN BENOVA, B. SZEIFFOVA BACOVA, V. DOSENKO, J. NAVAROVA, B. OBSITNIK, I. IMANAGA, T. SOUKUP, N. TRIBULOVA
  Physiological Research.2015; : 795.     CrossRef
• Does Bosentan Protect Diabetic Brain Alterations in Rats? The Role of Endothelin‐1 in the Diabetic Brain
  Recep Demir, Elif Cadirci, Erol Akpinar, Yasemin Cayir, Hasan Tarik Atmaca, Harun Un, Celalettin Semih Kunak, Muhammed Yayla, Zafer Bayraktutan, Ilknur Demir
  Basic & Clinical Pharmacology & Toxicology.2015; 116(3): 236.     CrossRef
• The effect of pioglitazone on aldosterone and cortisol production in HAC15 human adrenocortical carcinoma cells
  Zhi-qiang Pan, Ding Xie, Vivek Choudhary, Mutsa Seremwe, Ying-Ying Tsai, Lawrence Olala, Xunsheng Chen, Wendy B. Bollag
  Molecular and Cellular Endocrinology.2014; 394(1-2): 119.     CrossRef
• Icariin Is A PPARα Activator Inducing Lipid Metabolic Gene Expression in Mice
  Yuan-Fu Lu, Yun-Yan Xu, Feng Jin, Qin Wu, Jing-Shan Shi, Jie Liu
  Molecules.2014; 19(11): 18179.     CrossRef
• Canola Oil Influence on Azoxymethane-induced Colon Carcinogenesis, Hypertriglyceridemia and Hyperglycemia in Kunming Mice
  Xiao-Qiong He, Simon Angelo Cichello, Jia-Li Duan, Jin Zhou
  Asian Pacific Journal of Cancer Prevention.2014; 15(6): 2477.     CrossRef
• Cardiovascular risks and benefits with oral drugs for Type 2 diabetes mellitus
  Emily Weidman-Evans, Steven M Metz, Jeffery D Evans
  Expert Review of Clinical Pharmacology.2014; 7(2): 225.     CrossRef
• Enhanced pan‐peroxisome proliferator‐activated receptor gene and protein expression in adipose tissue of diet‐induced obese mice treated with telmisartan
  Aline Penna‐de‐Carvalho, Francielle Graus‐Nunes, Júlia Rabelo‐Andrade, Carlos Alberto Mandarim‐de‐Lacerda, Vanessa Souza‐Mello
  Experimental Physiology.2014; 99(12): 1663.     CrossRef

The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. Therefore, a novel therapeutic strategy by which to prevent T2DM is urgently required. Calorie restriction (CR) can retard the aging processes, and delay the onset of numerous age-related diseases including diabetes. Metabolic CR mimetics may be therefore included as novel therapeutic targets for T2DM. Sirtuin 1 (SIRT1), a NAD⁺-dependent histone deacetylase that is induced by CR, is closely associated with lifespan elongation under CR. SIRT1 regulates glucose/lipid metabolism through its deacetylase activity on many substrates. SIRT1 in pancreatic β-cells positively regulates insulin secretion and protects cells from oxidative stress and inflammation, and has positive roles in the metabolic pathway via the modulation in insulin signaling. SIRT1 also regulates adiponectin secretion, inflammation, glucose production, oxidative stress, mitochondrial function, and circadian rhythms. Several SIRT1 activators, including resveratrol have been demonstrated to have beneficial effects on glucose homeostasis and insulin sensitivity in animal models of insulin resistance. Therefore, SIRT1 may be a novel therapeutic target for the prevention of T2DM, implicating with CR. In this review, we summarize current understanding of the biological functions of SIRT1 and discuss its potential as a promising therapeutic target for T2DM.

Citations

Citations to this article as recorded by  

• SIRT1: a promising therapeutic target in type 2 diabetes mellitus
  Ainaz Mihanfar, Maryam Akbarzadeh, Saber Ghazizadeh Darband, Shirin Sadighparvar, Maryam Majidinia
  Archives of Physiology and Biochemistry.2024; 130(1): 13.     CrossRef
• The Role of Medicinal Plants in the Treatment and Management of Type 2 Diabetes
  Tirna Paul, Kalyani Pathak, Riya Saikia, Urvashee Gogoi, Jon Jyoti Sahariah, Aparoop Das
  Current Traditional Medicine.2024;[Epub]     CrossRef
• The favorable impacts of cardamom on related complications of diabetes: A comprehensive literature systematic review
  Ramin Nasimi Doost Azgomi, Arash Karimi, Arezoo Moini Jazani
  Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2024; 18(2): 102947.     CrossRef
• Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases
  Helena Trevisan Schroeder, Carlos Henrique De Lemos Muller, Thiago Gomes Heck, Mauricio Krause, Paulo Ivo Homem de Bittencourt
  Cell Stress and Chaperones.2024; 29(1): 116.     CrossRef
• circGlis3 promotes β-cell dysfunction by binding to heterogeneous nuclear ribonucleoprotein F and encoding Glis3-348aa protein
  Li Xiong, Yingying Gong, Huashan Liu, Liang Huang, Ziwei Zeng, Xiaobin Zheng, Wenxin Li, Zhenxing Liang, Liang Kang
  iScience.2024; 27(1): 108680.     CrossRef
• Nephro‐protective effects of alpha‐lipoic acid in type I diabetes
  Kriti Kushwaha, Debojyoti Mandal, Navneet Khurana, Jeena Gupta
  Journal of Biochemical and Molecular Toxicology.2024;[Epub]     CrossRef
• Potential roles of ellagic acid on metabolic variables in diabetes mellitus: A systematic review
  Vahid Maleki, Sepideh Abbaszadeh, Seyyed Morteza Seyyed Shoura, Asma Sohrabnavi, Mojtaba Sepandi, Maryam Taghdir
  Clinical and Experimental Pharmacology and Physiology.2023; 50(2): 121.     CrossRef
• Agomelatine improves streptozotocin-induced diabetic nephropathy through melatonin receptors/SIRT1 signaling pathway
  Nevertyty M. Mahmoud, Shimaa M. Elshazly, Arwa A. Hassan, Eman Soliman
  International Immunopharmacology.2023; 115: 109646.     CrossRef
• Effect of Oleanolic acid administration on hepatic AMPK, SIRT-1, IL-6 and NF-κB levels in experimental diabetes
  Hatice Iskender, Eda Dokumacioglu, Kubra Asena Terim Kapakin, Ismail Bolat, Behzat Mokhtare, Armagan Hayirli, Guler Yenice
  Journal of Diabetes & Metabolic Disorders.2023; 22(1): 581.     CrossRef
• Antidiabetic activity of Berberis brandisiana is possibly mediated through modulation of insulin signaling pathway, inflammatory cytokines and adipocytokines in high fat diet and streptozotocin-administered rats
  Shumaila Mehdi, Malik Hassan Mehmood, Mobeen Ghulam Ahmed, Usman Ali Ashfaq
  Frontiers in Pharmacology.2023;[Epub]     CrossRef
• The Pathogenesis of Diabetes
  Huiqin Guo, Haili Wu, Zhuoyu Li
  International Journal of Molecular Sciences.2023; 24(8): 6978.     CrossRef
• Food Polyphenols and Type II Diabetes Mellitus: Pharmacology and Mechanisms
  Rabia Naz, Fatima Saqib, Samir Awadallah, Muqeet Wahid, Muhammad Farhaj Latif, Iram Iqbal, Mohammad S. Mubarak
  Molecules.2023; 28(10): 3996.     CrossRef
• Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets
  Noura Aldous, Abu Saleh Md Moin, Essam M. Abdelalim
  Cellular and Molecular Life Sciences.2023;[Epub]     CrossRef
• Mechanistic and Etiological Similarities in Diabetes Mellitus and Alzheimer’s Disease: Antidiabetic Drugs as Optimistic Therapeutics in Alzheimer’s Disease
  Subham Das, Anu Kunnath Ramachandran, Debojyoti Halder, Saleem Akbar, Bahar Ahmed, Alex Joseph
  CNS & Neurological Disorders - Drug Targets.2023; 22(7): 973.     CrossRef
• Resveratrol ameliorates triglyceride accumulation through FXR deacetylation in high glucose-treated HepG2 cells
  Hao Yang, Yongjin Sun, Jinling Zhang, Shan Xu, Lidan Tang, Jinhong Gong, Hufeng Fang, Ying Lin, Jie Ren, Dan Su
  Journal of Functional Foods.2023; 107: 105679.     CrossRef
• A Potential Role for Sirtuin-1 in Alzheimer’s Disease: Reviewing the Biological and Environmental Evidence
  Mehrane Mehramiz, Tenielle Porter, Eleanor K. O’Brien, Stephanie R. Rainey-Smith, Simon M. Laws, Craig Atwood
  Journal of Alzheimer's Disease Reports.2023; 7(1): 823.     CrossRef
• Pathophysiology of diabetic kidney disease and autophagy: A review
  Jiawei Yu, Yan Liu, Hongjie Li, Peirong Zhang
  Medicine.2023; 102(30): e33965.     CrossRef
• Low sirtuin-1 levels are associated with gestational diabetes mellitus
  Hasan ULUBASOGLU, Necati HANCERLIOGULLARI, Aytekin TOKMAK, Levent H. KESKIN, Tuba CANDAR, Ozlem MORALOGLU TEKIN
  Minerva Endocrinology.2023;[Epub]     CrossRef
• Effect of resistance training and high-intensity interval training on metabolic parameters and serum level of Sirtuin1 in postmenopausal women with metabolic syndrome: a randomized controlled trial
  Saeid Shamlou Kazemi, Ali Heidarianpour, Elnaz Shokri
  Lipids in Health and Disease.2023;[Epub]     CrossRef
• Purple Napiergrass (Pennisetum purpureum Schumach) Hot Water Extracts Ameliorate High-Fat Diet-Induced Obesity and Metabolic Disorders in Mice
  Pin-Yu Ho, Yen-Chun Koh, Ting-Jang Lu, Po-Lin Liao, Min-Hsiung Pan
  Journal of Agricultural and Food Chemistry.2023; 71(51): 20701.     CrossRef
• The role of sirtuins in the regulatin of oxidative stress during the progress and therapy of type 2 diabetes mellitus
  Jiawen Chen, Qi Wang, Ruiyan Li, Zhe Li, Qizhou Jiang, Fangrong Yan, Junmei Ye
  Life Sciences.2023; 333: 122187.     CrossRef
• Investigation of polymorphism role in protein structure and function for selected cancer and diabetes disease; a rationale to selection of targets for insilico drug screening
  Christopher Busayo Olowosoke, Tope Abraham Ibisanmi, Chioma Joy Eze, Abayomi Abiodun Shofunde, Tomiwa Lois Olubena, Olalekan Akadiri
  Informatics in Medicine Unlocked.2023; 42: 101342.     CrossRef
• Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer’s Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways
  Da-Tong Ju, Rwei-Fen S. Huang, Bruce Chi-Kang Tsai, Yi-Chen Su, Ping-Ling Chiu, Yung-Ming Chang, V. Vijaya Padma, Tsung-Jung Ho, Chun-Hsu Yao, Wei-Wen Kuo, Chih-Yang Huang
  Neurotoxicity Research.2023; 41(6): 648.     CrossRef
• Role of microRNA-34a in blood–brain barrier permeability and mitochondrial function in ischemic stroke
  Cole T. Payne, Sidra Tabassum, Silin Wu, Heng Hu, Aaron M. Gusdon, Huimahn A. Choi, Xuefang S. Ren
  Frontiers in Cellular Neuroscience.2023;[Epub]     CrossRef
• Resveratrol and Markers of Polycystic Ovary Syndrome: a Systematic Review of Animal and Clinical Studies
  Sara Shojaei-Zarghani, Maryam Rafraf
  Reproductive Sciences.2022; 29(9): 2477.     CrossRef
• Efficacy of artemisinin and its derivatives in animal models of type 2 diabetes mellitus: A systematic review and meta-analysis
  Tingchao Wu, Haoyue Feng, Mingmin He, Rensong Yue, Shaoqi Wu
  Pharmacological Research.2022; 175: 105994.     CrossRef
• The effect of 12 weeks of training in water on serum levels of SIRT1 and FGF-21, glycemic index, and lipid profile in patients with type 2 diabetes
  Bahram Jamali Gharakhanlou, Solmaz Babaei Bonab
  International Journal of Diabetes in Developing Countries.2022; 42(4): 727.     CrossRef
• New insights into the role of melatonin in diabetic cardiomyopathy
  Keming Huang, Xianling Luo, Yi Zhong, Li Deng, Jian Feng
  Pharmacology Research & Perspectives.2022;[Epub]     CrossRef
• Obesity and Male Reproduction: Do Sirtuins Play a Role?
  Federica Barbagallo, Sandro La Vignera, Rossella Cannarella, Laura M. Mongioì, Vincenzo Garofalo, Claudia Leanza, Marta Marino, Aldo E. Calogero, Rosita A. Condorelli
  International Journal of Molecular Sciences.2022; 23(2): 973.     CrossRef
• Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns
  Xinzhu Liu, Dawei Li, Zhaoxing Liu, Yaoyao Song, Bohan Zhang, Yu Zang, Wen Zhang, Yuezeng Niu, Chuan’an Shen
  Burns.2022; 48(8): 1922.     CrossRef
• d-Allulose Ameliorates Hyperglycemia Through IRE1α Sulfonation-RIDD-Sirt1 Decay Axis in the Skeletal Muscle
  Hwa-Young Lee, Geum-Hwa Lee, The-Hiep Hoang, Seon-Ah Park, Juwon Lee, Junghyun Lim, Soonok Sa, Go Eun Kim, Jung Sook Han, Junghyun Kim, Han-Jung Chae
  Antioxidants & Redox Signaling.2022; 37(4-6): 229.     CrossRef
• GABA and Fermented Curcuma longa L. Extract Enriched with GABA Ameliorate Obesity through Nox4-IRE1α Sulfonation-RIDD-SIRT1 Decay Axis in High-Fat Diet-Induced Obese Mice
  Hwa-Young Lee, Geum-Hwa Lee, The-Hiep Hoang, Yu-Mi Kim, Gi-Hyun Jang, Chang-Hwan Seok, Yun-Geum-Sang Gwak, Junghyun Lim, Junghyun Kim, Han-Jung Chae
  Nutrients.2022; 14(8): 1680.     CrossRef
• Resveratrol regulates Hsp60 in HEK 293T cells during activation of SIRT1 revealed by nascent protein labeling strategy
  Tian Su, Zhen Wang, Zhengyi Zhang, Zhanwu Hou, Xiao Han, Fei Yang, Huadong Liu
  Food & Nutrition Research.2022;[Epub]     CrossRef
• Effect of cardamom supplementation on a number of metabolic factors: A systematic review and meta-analysis
  Ghazaleh Nameni, Yousef Moradi, Marsa Zaroudi, Sanaz Jamshidi
  Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2022; 16(6): 102523.     CrossRef
• The mitochondrial unfolded protein response: A multitasking giant in the fight against human diseases
  Zixin Zhou, Yumei Fan, Ruikai Zong, Ke Tan
  Ageing Research Reviews.2022; 81: 101702.     CrossRef
• Cardioprotective Effects of 1-(3,6-Dibromo-carbazol-9-yl)-3-Phenylamino-Propan-2-Ol in Diabetic Hearts via Nicotinamide Phosphoribosyltransferase Activation
  Jared Tur, Sachin L. Badole, Ravikumar Manickam, Kalyan C. Chapalamadugu, Wanling Xuan, Wayne Guida, Jaret J. Crews, Kirpal S. Bisht, Srinivas M. Tipparaju
  Journal of Pharmacology and Experimental Therapeutics.2022; 382(2): 233.     CrossRef
• Celastrol: A Promising Agent Fighting against Cardiovascular Diseases
  Zhexi Li, Jingyi Zhang, Xulei Duan, Guoan Zhao, Min Zhang
  Antioxidants.2022; 11(8): 1597.     CrossRef
• The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome
  Mali Wu, Jie Zhang, Ran Gu, Fangfang Dai, Dongyong Yang, Yajing Zheng, Wei Tan, Yifan Jia, Bingshu Li, Yanxiang Cheng
  European Journal of Medical Research.2022;[Epub]     CrossRef
• Anti-apoptotic properties of N-Acetyl cysteine and its effects on of Liver X receptor and Sirtuin 1 expression in the liver of rats exposed to Lead
  Asghar Beigi Harchegani, Sareh Rostami, Zhaleh Mohsenifar, Alireza Beheshti Dafchahi, Fatemeh Mozaffari Moghadam, Mohammad Jaafarzadeh, Saman Seyfizadeh Saraabestan, Najmeh Ranji
  Journal of Trace Elements in Medicine and Biology.2022; 74: 127070.     CrossRef
• Caloric Restriction, Friend or Foe: Effects on Metabolic Status in Association with the Intestinal Microbiome and Metabolome
  Xiangnan Zhang, Lin Shi, Qiannan Li, Chaofan Song, Ning Han, Tao Yan, Liansheng Zhang, Daoyuan Ren, Yan Zhao, Xingbin Yang
  Journal of Agricultural and Food Chemistry.2022; 70(43): 14061.     CrossRef
• Effects of Fruit and Vegetable Polyphenols on the Glycemic Control and Metabolic Parameters in Type 2 Diabetes Mellitus: A Review
  Che Anis Jauharah Che Mohd Zin, Wan Mohd Izani Wan Mohamed, Nurzalina Abdul Karim Khan, Wan Rosli Wan Ishak
  Preventive Nutrition and Food Science.2022; 27(3): 257.     CrossRef
• Berberine mitigates hepatic insulin resistance by enhancing mitochondrial architecture via the SIRT1/Opa1 signalling pathway
  Jia Xu, Yining Zhang, Zhiyi Yu, Yueqi Guan, Yuqian Lv, Meishuang Zhang, Ming Zhang, Li Chen, Xiaoyan Lv, Fengying Guan
  Acta Biochimica et Biophysica Sinica.2022; 54(10): 1464.     CrossRef
• The Role of p66Shc in Diabetes: A Comprehensive Review from Bench to Bedside
  SeyedehFatemeh Mousavi, Mohammad Amin Khazeei Tabari, Alireza Bagheri, Noosha Samieefar, Negar Shaterian, Roya Kelishadi, Eusebio Chiefari
  Journal of Diabetes Research.2022; 2022: 1.     CrossRef
• Systematic Insight of Resveratrol Activated SIRT1 Interactome through Proximity Labeling Strategy
  Tian Su, Zhengyi Zhang, Xiao Han, Fei Yang, Zhen Wang, Ying Cheng, Huadong Liu
  Antioxidants.2022; 11(12): 2330.     CrossRef
• Effects of Resveratrol Supplementation and Exercise on Apoptosis, Lipid Profile, and Expression of Farnesoid X Receptor, Liver X Receptor and Sirtuin 1 Genes in the Liver of Type 1 Diabetic Rats
  Ali Nouri, Parvin Farzanegi, Mohammad Ali Azarbayjani
  Medical Laboratory Journal.2022; 16(4): 39.     CrossRef
• SIRT1 functional polymorphisms (rs12778366, rs3758391) as genetic biomarkers of susceptibility to type 2 diabetes mellitus in Iranians: a case-control study and computational analysis
  Mohammad Bagher Sadeghi, Alireza Nakhaee, Ramin Saravani, Mohammad Hassan Sadeghi, Saman Sargazi, Milad Heidari Nia
  International Journal of Diabetes in Developing Countries.2021; 41(3): 447.     CrossRef
• Elucidation of Structural Determinants Delineates the Residues Playing Key Roles in Differential Dynamics and Selective Inhibition of Sirt1–3
  Mrityunjay Singh, Mitul Srivastava, Sharad R. Wakode, Shailendra Asthana
  Journal of Chemical Information and Modeling.2021; 61(3): 1105.     CrossRef
• Discovery and characterization of small molecule SIRT3-specific inhibitors as revealed by mass spectrometry
  Saurabh Loharch, Sonali Chhabra, Abhinit Kumar, Sapna Swarup, Raman Parkesh
  Bioorganic Chemistry.2021; 110: 104768.     CrossRef
• Exploring the recent molecular targets for diabetes and associated complications
  Amit Gupta, Tapan Behl, Aayush Sehgal, Shaveta Bhardwaj, Sukhbir Singh, Neelam Sharma, Abdul Hafeez
  Molecular Biology Reports.2021; 48(3): 2863.     CrossRef
• Opportunities and challenges of algal fucoidan for diabetes management
  Yuxi Wen, Luying Gao, Hengsheng Zhou, Chao Ai, Xiaozhou Huang, Mingfu Wang, Yuyu Zhang, Chao Zhao
  Trends in Food Science & Technology.2021; 111: 628.     CrossRef
• The effect of N-Acetyl cysteine on the expression of Fxr (Nr1h4), LXRα (Nr1h3) and Sirt1 genes, oxidative stress, and apoptosis in the liver of rats exposed to different doses of cadmium
  Zahra Azarmehr, Najmeh Ranji, Zeinab Khazaei Koohpar, Hadi Habibollahi
  Molecular Biology Reports.2021; 48(3): 2533.     CrossRef
• Maternal obesity as a risk factor for developing diabetes in offspring: An epigenetic point of view
  Simon Lecoutre, Salwan Maqdasy, Christophe Breton
  World Journal of Diabetes.2021; 12(4): 366.     CrossRef
• Sirtuin 1 ve Sirtuin 2’nin Tip 2 Diyabet ile İlişkisi
  İlke ULU, Güneş ÇAKMAK GENÇ, Sevim KARAKAŞ ÇELİK
  Turkish Journal of Diabetes and Obesity.2021; 5(1): 81.     CrossRef
• Human SHC‐transforming protein 1 and its isoforms p66shc: A novel marker for prediabetes
  Herbert F Jelinek, Charlotte Helf, Kinda Khalaf
  Journal of Diabetes Investigation.2021; 12(10): 1881.     CrossRef
• An Insight into Giant Cell Arteritis Pathogenesis: Evidence for Oxidative Stress and SIRT1 Downregulation
  Alessandro Ianni, Poonam Kumari, Shahriar Tarighi, Flavia Rita Argento, Eleonora Fini, Giacomo Emmi, Alessandra Bettiol, Thomas Braun, Domenico Prisco, Claudia Fiorillo, Matteo Becatti
  Antioxidants.2021; 10(6): 885.     CrossRef
• Case Report of Impaired Fasting Glucose Improved with Korean Medicine Treatment and Dietetic Therapy
  Eun-mi Kim, Ki-tae Kim
  The Journal of Internal Korean Medicine.2021; 42(2): 175.     CrossRef
• Can resveratrol modulate sirtuins in obesity and related diseases? A systematic review of randomized controlled trials
  Gabriela Macedo Fraiz, Aline Rosignoli da Conceição, Darlene Larissa de Souza Vilela, Daniela Mayumi Usuda Prado Rocha, Josefina Bressan, Helen Hermana Miranda Hermsdorff
  European Journal of Nutrition.2021; 60(6): 2961.     CrossRef
• Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome
  Aynaz Mihanfar, Mohammad Nouri, Leila Roshangar, Mohammad Hassan Khadem-Ansari
  The Journal of Steroid Biochemistry and Molecular Biology.2021; 213: 105954.     CrossRef
• The effect of daily intake of vitamin D-fortified yogurt drink, with and without added calcium, on serum adiponectin and sirtuins 1 and 6 in adult subjects with type 2 diabetes
  Bahareh Nikooyeh, Bruce W. Hollis, Tirang R. Neyestani
  Nutrition & Diabetes.2021;[Epub]     CrossRef
• Up-regulation of GLP-1R improved the dysfunction of late EPCs under hyperglycemia by regulating SIRT1 expression
  Qiang Tu, Jun-feng Wang, Hua-qiang Xie, Qi Zhao, Jie Fu, Hua-lin Xu, Zheng Cao
  Molecular and Cellular Endocrinology.2021; 538: 111455.     CrossRef
• Therapeutic Screening of Herbal Remedies for the Management of Diabetes
  Mahmoud Balbaa, Marwa El-Zeftawy, Shaymaa A. Abdulmalek
  Molecules.2021; 26(22): 6836.     CrossRef
• microRNA‐141 is associated with hepatic steatosis by downregulating the sirtuin1/AMP‐activated protein kinase pathway in hepatocytes
  Zeynab Yousefi, Mitra Nourbakhsh, Zohreh Abdolvahabi, Seyedeh‐Sara Ghorbanhosseini, Zahra Hesari, Sahar Yarahmadi, Samira Ezzati‐Mobasser, Parvane Seiri, Mohammad Borji, Reza Meshkani, Mojtaba Malek
  Journal of Cellular Physiology.2020; 235(2): 880.     CrossRef
• Trifolium pratense (Red Clover) Improve SIRT1 Expression and Glycogen Content in High Fat Diet‐Streptozotocin Induced Type 2 Diabetes in Rats
  Manisha J. Oza, Yogesh A. Kulkarni
  Chemistry & Biodiversity.2020;[Epub]     CrossRef
• Additive Effect of Resveratrol on Astrocyte Swelling Post-exposure to Ammonia, Ischemia and Trauma In Vitro
  Mehran Taherian, Michael D. Norenberg, Kiran S. Panickar, Nagarajarao Shamaladevi, Anis Ahmad, Purbasha Rahman, Arumugam R. Jayakumar
  Neurochemical Research.2020; 45(5): 1156.     CrossRef
• Association of the rs3758391 polymorphism in the SIRT1 gene with diabetic nephropathy and decreased estimated glomerular filtration rate (GFR) in a population from southwest Iran
  Ramin Tavakoli Faradonbeh, Mehrnoosh Zakerkish, Ali Karimi Akhormeh, Narges Mohammadtaghvaei, Mohammad Taha Jalali, Hamid Yaghooti
  International Journal of Diabetes in Developing Countries.2020; 40(1): 99.     CrossRef
• Hydrogen Sulfide Ameliorates Lung Ischemia-Reperfusion Injury Through SIRT1 Signaling Pathway in Type 2 Diabetic Rats
  Tao Jiang, Weiwei Yang, Hongli Zhang, Zhiqiang Song, Tianhua Liu, Xiangqi Lv
  Frontiers in Physiology.2020;[Epub]     CrossRef
• Lycium barbarum Polysaccharides Improve Testicular Spermatogenic Function in Streptozotocin-Induced Diabetic Rats
  Xiaocan Lei, Peng Huo, Yaohui Wang, Yuanjie Xie, Qingxiang Shi, Haoyan Tu, Jun Yao, Zhongcheng Mo, Shun Zhang
  Frontiers in Endocrinology.2020;[Epub]     CrossRef
• Maya gene variants related to the risk of type 2 diabetes in a family-based association study
  Miriam G. Domínguez-Cruz, María de Lourdes Muñoz, Armando Totomoch-Serra, María G. García-Escalante, Juan Burgueño, Nina Valadez-González, Doris Pinto-Escalante, Alvaro Díaz-Badillo
  Gene.2020; 730: 144259.     CrossRef
• Development of activity-based probes for the protein deacylase Sirt1
  Christopher J. Goetz, Daniel J. Sprague, Brian C. Smith
  Bioorganic Chemistry.2020; 104: 104232.     CrossRef
• Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK/SIRT1 signaling pathways
  Mohamad Hafizi Abu Bakar, Khairul Anuar Shariff, Joo Shun Tan, Lai Kuan Lee
  European Journal of Pharmacology.2020; 883: 173371.     CrossRef
• SCD1 regulates the AMPK/SIRT1 pathway and histone acetylation through changes in adenine nucleotide metabolism in skeletal muscle
  Anna Dziewulska, Aneta M. Dobosz, Agnieszka Dobrzyn, Agnieszka Smolinska, Katarzyna Kolczynska, James M. Ntambi, Pawel Dobrzyn
  Journal of Cellular Physiology.2020; 235(2): 1129.     CrossRef
• Effect of Quamoclit angulata Extract Supplementation on Oxidative Stress and Inflammation on Hyperglycemia-Induced Renal Damage in Type 2 Diabetic Mice
  Ji Eun Park, Heaji Lee, Hyunkyung Rho, Seong Min Hong, Sun Yeou Kim, Yunsook Lim
  Antioxidants.2020; 9(6): 459.     CrossRef
• Effect of green cardamom on lipoproteins, glycemic control and anthropometric parameters: A meta-analysis of randomized clinical trials
  Omid Asbaghi, Elham Eslampour, Željko Reiner, Bita Badehnoosh, Fariba Kolahdooz, Sajjad Moradi, Shahrzad Hashemi Dizaji, Zatollah Asemi
  Clinical Nutrition ESPEN.2020; 37: 24.     CrossRef
• The Potential Roles of Artemisinin and Its Derivatives in the Treatment of Type 2 Diabetes Mellitus
  Ya-yi Jiang, Jia-cheng Shui, Bo-xun Zhang, Jia-wei Chin, Ren-song Yue
  Frontiers in Pharmacology.2020;[Epub]     CrossRef
• Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine
  Yun Shan, Shuchen Zhang, Bin Gao, Shu Liang, Hao Zhang, Xizhong Yu, Juan Zhao, Lifang Ye, Qin Yang, Wenbin Shang
  Frontiers in Pharmacology.2020;[Epub]     CrossRef
• Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats
  Jianjian Zhang, Lei Wang, Daojing Gong, Yuanyuan Yang, Xiuheng Liu, Zhiyuan Chen
  Molecular Medicine Reports.2019;[Epub]     CrossRef
• Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double‐blind placebo controlled clinical trial
  Mohadeseh Aghasi, Fariba Koohdani, Mostafa Qorbani, Ensieh Nasli‐Esfahani, Shohreh Ghazi‐Zahedi, Hoorieh Khoshamal, Ali Keshavarz, Gity Sotoudeh
  Journal of the Science of Food and Agriculture.2019; 99(8): 3933.     CrossRef
• A Review of Type 2 Diabetes Mellitus Predisposing Genes
  Tajudeen O. Yahaya, Titilola F. Salisu
  Current Diabetes Reviews.2019; 16(1): 52.     CrossRef
• Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice
  Hung-Wen Liu, Hao-Han Kao, Chi-Hang Wu
  Nutrition & Metabolism.2019;[Epub]     CrossRef
• Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases
  Naveet Pannu, Archana Bhatnagar
  Biomedicine & Pharmacotherapy.2019; 109: 2237.     CrossRef
• The Effect of Resveratrol Supplementation on Cardio‐Metabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, Double‐Blind Controlled Trial
  Shima Abdollahi, Amin Salehi‐Abargouei, Omid Toupchian, Mohammad Hasan Sheikhha, Hossein Fallahzadeh, Masoud Rahmanian, Mahtab Tabatabaie, Hassan Mozaffari‐Khosravi
  Phytotherapy Research.2019; 33(12): 3153.     CrossRef
• Sirtuins and diabetes: optimizing the sweetness in the blood
  Abhinav Kanwal, Liston Augustine Dsouza
  Translational Medicine Communications.2019;[Epub]     CrossRef
• In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database
  Azminah Azminah, Linda Erlina, Maksum Radji, Abdul Mun’im, Rezi Riadhi Syahdi, Arry Yanuar
  Computational Biology and Chemistry.2019; 83: 107096.     CrossRef
• Ginsenoside Rb1 Attenuates High Glucose-Induced Oxidative Injury via the NAD-PARP-SIRT Axis in Rat Retinal Capillary Endothelial Cells
  Chunlan Fan, Qing Ma, Meng Xu, Yuan Qiao, Yi Zhang, Pin Li, Yucong Bi, Minke Tang
  International Journal of Molecular Sciences.2019; 20(19): 4936.     CrossRef
• Effects and Underlying Mechanisms of Bioactive Compounds on Type 2 Diabetes Mellitus and Alzheimer’s Disease
  Rongzi Li, Yuxian Zhang, Suhail Rasool, Thangiah Geetha, Jeganathan Ramesh Babu
  Oxidative Medicine and Cellular Longevity.2019; 2019: 1.     CrossRef
• Selection of reference genes for miRNA quantitative PCR and its application in miR-34a/Sirtuin-1 mediated energy metabolism in Megalobrama amblycephala
  Jie Liu, Erteng Jia, Huajuan Shi, Xiangfei Li, Guangzhen Jiang, Cheng Chi, Wenbin Liu, Dingdong Zhang
  Fish Physiology and Biochemistry.2019; 45(5): 1663.     CrossRef
• Fucoxanthin Alleviates Oxidative Stress through Akt/Sirt1/FoxO3α Signaling to Inhibit HG-Induced Renal Fibrosis in GMCs
  Guanyu Yang, Lin Jin, Dongxiao Zheng, Xiaoliang Tang, Junwei Yang, Lingxuan Fan, Xi Xie
  Marine Drugs.2019; 17(12): 702.     CrossRef
• Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway
  Si Shi, Shaoqing Lei, Chaoliang Tang, Kai Wang, Zhongyuan Xia
  Bioscience Reports.2019;[Epub]     CrossRef
• Rhizoma Paridis total saponins alleviate H2O2‑induced oxidative stress injury by upregulating the Nrf2 pathway
  Baocheng Zhao, Zhenjun Wang, Jiagang Han, Guanghui Wei, Bingqiang Yi, Zhulin Li
  Molecular Medicine Reports.2019;[Epub]     CrossRef
• Role of sirtuin-1 in diabetic nephropathy
  Wanning Wang, Weixia Sun, Yanli Cheng, Zhonggao Xu, Lu Cai
  Journal of Molecular Medicine.2019; 97(3): 291.     CrossRef
• Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function
  Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koya
  Frontiers in Endocrinology.2019;[Epub]     CrossRef
• Mechanistic insights into the effect of lutein on atherosclerosis, vascular dysfunction, and related risk factors: A systematic review of in vivo, ex vivo and in vitro studies
  Fatemeh Hajizadeh-Sharafabad, Zohreh Ghoreishi, Vahid Maleki, Ali Tarighat-Esfanjani
  Pharmacological Research.2019; 149: 104477.     CrossRef
• Chronic whole-body heat treatment relieves atherosclerotic lesions, cardiovascular and metabolic abnormalities, and enhances survival time restoring the anti-inflammatory and anti-senescent heat shock response in mice
  Maciel Alencar Bruxel, Angela Maria Vicente Tavares, Luiz Domingues Zavarize Neto, Victor de Souza Borges, Helena Trevisan Schroeder, Patricia Martins Bock, Maria Inês Lavina Rodrigues, Adriane Belló-Klein, Paulo Ivo Homem de Bittencourt
  Biochimie.2019; 156: 33.     CrossRef
• Swimming training by affecting the pancreatic Sirtuin1 (SIRT1) and oxidative stress, improves insulin sensitivity in diabetic male rats
  Rafighe Ghiasi, Roya Naderi, Roghayeh Sheervalilou, Mohammad Reza Alipour
  Hormone Molecular Biology and Clinical Investigation.2019;[Epub]     CrossRef
• Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Type 2 Diabetes Show Reduced “Stemness” through an Altered Secretome Profile, Impaired Anti-Oxidative Protection, and Mitochondrial Dynamics Deterioration
  Michalina Alicka, Piotr Major, Michał Wysocki, Krzysztof Marycz
  Journal of Clinical Medicine.2019; 8(6): 765.     CrossRef
• A novel recombinant peptide INSR-IgG4Fc (Yiminsu) restores insulin sensitivity in experimental insulin resistance models
  Jing Wang, Zhe Shi, Tao Zou, Min-Xu Zou, Hui-Xian Yang, Cai-Ping Zhang, De-Biao Xiang, Li-Mei Lin, Hui-Yu Liu, De-yu Fang, Duan-Fang Liao
  Biomedicine & Pharmacotherapy.2019; 109: 1276.     CrossRef
• Immunometabolism and Pulmonary Infections: Implications for Protective Immune Responses and Host-Directed Therapies
  Martin Rao, Ernest Dodoo, Alimuddin Zumla, Markus Maeurer
  Frontiers in Microbiology.2019;[Epub]     CrossRef
• Salvianolic Acid B Attenuates Apoptosis of HUVEC Cells Treated with High Glucose or High Fat via Sirt1 Activation
  Jinghui Zhai, Lina Tao, Yueming Zhang, Huan Gao, Xiaoyu Qu, Yanqing Song, Sixi Zhang
  Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1.     CrossRef
• Obesity programmed by prenatal dexamethasone and postnatal high-fat diet leads to distinct alterations in nutrition sensory signals and circadian-clock genes in visceral adipose tissue
  Ching-Chou Tsai, Mao-Meng Tiao, Jiunn-Ming Sheen, Li-Tung Huang, You-Lin Tain, I-Chun Lin, Yu-Ju Lin, Yun-Ju Lai, Chih-Cheng Chen, Kow-Aung Chang, Hong-Ren Yu
  Lipids in Health and Disease.2019;[Epub]     CrossRef
• Mapping Research in the Obesity, Adipose Tissue, and MicroRNA Field: A Bibliometric Analysis
  João Manoel Alves, Ramon Handerson Gomes Teles, Camila do Valle Gomes Gatto, Vitor Rosetto Muñoz, Márcia Regina Cominetti, Ana Cláudia Garcia de Oliveira Duarte
  Cells.2019; 8(12): 1581.     CrossRef
• Chronic hypoglycemic effect and phytochemical composition of Smilax moranensis roots
  Adriana Romo-Pérez, Sonia Marlen Escandón-Rivera, Adolfo Andrade-Cetto
  Revista Brasileira de Farmacognosia.2019; 29(2): 246.     CrossRef
• Prevention of kidney cell damage in hyperglycaemia condition by adiponectin
  Sajad Esmaeili, Maryam Motamedrad, Mina Hemmati, Omid Mehrpour, Mohsen Khorashadizadeh
  Cell Biochemistry and Function.2019; 37(3): 148.     CrossRef
• Molecular Mechanism of the Protective Effect of Zerumbone on Lipopolysaccharide-Induced Inflammation of THP-1 Cell-Derived Macrophages
  Min-Ju Kim, Jung-Mi Yun
  Journal of Medicinal Food.2019; 22(1): 62.     CrossRef
• Impairment of PPARα and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging
  Ki Wung Chung, Eun Kyeong Lee, Mi Kyung Lee, Goo Taeg Oh, Byung Pal Yu, Hae Young Chung
  Journal of the American Society of Nephrology.2018; 29(4): 1223.     CrossRef
• Pomegranate Juice Increases Sirtuin1 Protein in Peripheral Blood Mononuclear Cell from Patients with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trial
  Golbon Sohrab, Javad Nasrollahzadeh, Maryam Tohidi, Hamid Zand, Omid Nikpayam
  Metabolic Syndrome and Related Disorders.2018; 16(8): 446.     CrossRef
• Effect of resveratrol treatment on graft revascularization after islet transplantation in streptozotocin-induced diabetic mice
  Eun-Mi Lee, Inwon Park, Ye-Jee Lee, Young-Hye You, Ji-Won Kim, Myung-Jun Kim, Yu-Bae Ahn, Pilhan Kim, Seung-Hyun Ko
  Islets.2018; 10(1): 25.     CrossRef
• miR‐221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin‐1 (SIRT1)
  Jie Peng, Yuanfei Zhou, Zhao Deng, Hong Zhang, Yinghui Wu, Tongxing Song, Yang Yang, Hongkui Wei, Jian Peng
  Journal of Cellular Biochemistry.2018; 119(8): 6418.     CrossRef
• Molecular Imaging of Sirtuin1 Expression–Activity in Rat Brain Using Positron-Emission Tomography–Magnetic-Resonance Imaging with [18F]-2-Fluorobenzoylaminohexanoicanilide
  Robin Bonomi, Vadim Popov, Maxwell T. Laws, David Gelovani, Anjoy Majhi, Aleksandr Shavrin, Xin Lu, Otto Muzik, Nashaat Turkman, Renshyan Liu, Thomas Mangner, Juri G. Gelovani
  Journal of Medicinal Chemistry.2018; 61(16): 7116.     CrossRef
• Vitamin B12 supplementation influences methylation of genes associated with Type 2 diabetes and its intermediate traits
  Dilip K Yadav, Smeeta Shrestha, Karen A Lillycrop, Charu V Joglekar, Hong Pan, Joanna D Holbrook, Caroline HD Fall, Chittaranjan S Yajnik, Giriraj R Chandak
  Epigenomics.2018; 10(1): 71.     CrossRef
• The effects of green cardamom supplementation on blood glucose, lipids profile, oxidative stress, sirtuin-1 and irisin in type 2 diabetic patients: a study protocol for a randomized placebo-controlled clinical trial
  Mohadeseh Aghasi, Shohreh Ghazi-Zahedi, Fariba Koohdani, Fereydoun Siassi, Ensieh Nasli-Esfahani, Ali Keshavarz, Mostafa Qorbani, Hoorieh Khoshamal, Asma Salari-Moghaddam, Gity Sotoudeh
  BMC Complementary and Alternative Medicine.2018;[Epub]     CrossRef
• LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling
  Ailing Li, Rui Peng, Yan Sun, Handeng Liu, Huimin Peng, Zheng Zhang
  Cell Death & Disease.2018;[Epub]     CrossRef
• Treatment of NASH with Antioxidant Therapy: Beneficial Effect of Red Cabbage on Type 2 Diabetic Rats
  Stéphanie Dal, Remmelt Van der Werf, Catherine Walter, William Bietiger, Elodie Seyfritz, Carole Mura, Claude Peronet, Julie Legrandois, Dalal Werner, Said Ennahar, Fabien Digel, Maillard-Pedracini Elisa, Michel Pinget, Nathalie Jeandidier, Eric Marchioni
  Oxidative Medicine and Cellular Longevity.2018; 2018: 1.     CrossRef
• Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia
  Manisha J. Oza, Yogesh A. Kulkarni
  Frontiers in Pharmacology.2018;[Epub]     CrossRef
• Tocotrienol-rich fraction supplementation reduces hyperglycemia-induced skeletal muscle damage through regulation of insulin signaling and oxidative stress in type 2 diabetic mice
  Heaji Lee, Yunsook Lim
  The Journal of Nutritional Biochemistry.2018; 57: 77.     CrossRef
• Circulating soluble RAGE isoforms are attenuated in obese, impaired-glucose-tolerant individuals and are associated with the development of type 2 diabetes
  Edwin R. Miranda, Vikram S. Somal, Jacob T. Mey, Brian K. Blackburn, Edward Wang, Sarah Farabi, Kristian Karstoft, Ciaran E. Fealy, Sangeeta Kashyap, John P. Kirwan, Laurie Quinn, Thomas P. J. Solomon, Jacob M. Haus
  American Journal of Physiology-Endocrinology and Metabolism.2017; 313(6): E631.     CrossRef
• Combination Treatments with Luteolin and Fisetin Enhance Anti-Inflammatory Effects in High Glucose-Treated THP-1 Cells Through Histone Acetyltransferase/Histone Deacetylase Regulation
  Arang Kim, Jung-Mi Yun
  Journal of Medicinal Food.2017; 20(8): 782.     CrossRef
• Fucoidan ameliorates pancreatic β‐cell death and impaired insulin synthesis in streptozotocin‐treated β cells and mice via a Sirt‐1‐dependent manner
  Wen‐Chun Yu, Yen‐Lin Chen, Pai‐An Hwang, Tso‐Hsiao Chen, Tz‐Chong Chou
  Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
• Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice
  Kun Zeng, Qi-Gao Feng, Bao-Tao Lin, Da-Hui Ma, Chun-Min Liu
  Bioscience Reports.2017;[Epub]     CrossRef
• Luteolin and fisetin suppress oxidative stress by modulating sirtuins and forkhead box O3a expression under in vitro diabetic conditions
  Arang Kim, Wooje Lee, Jung-Mi Yun
  Nutrition Research and Practice.2017; 11(5): 430.     CrossRef
• Melatonin and the pathologies of weakened or dysregulated circadian oscillators
  Rüdiger Hardeland
  Journal of Pineal Research.2017;[Epub]     CrossRef
• HSF1 acetylation decreases its transcriptional activity and enhances glucolipotoxicity-induced apoptosis in rat and human beta cells
  Indri Purwana, Jun J. Liu, Bernard Portha, Jean Buteau
  Diabetologia.2017; 60(8): 1432.     CrossRef
• Tangshen formula improves inflammation in renal tissue of diabetic nephropathy through SIRT1/NF-κB pathway
  Yue‑Guang Du, Ke‑Na Zhang, Zong‑Lei Gao, Fengjiao Dai, Xi‑Xi Wu, Ke‑Fu Chai
  Experimental and Therapeutic Medicine.2017;[Epub]     CrossRef
• MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1)
  Jie Peng, Yinghui Wu, Zhao Deng, Yuanfei Zhou, Tongxing Song, Yang Yang, Xiaming Zhang, Tao Xu, Mao Xia, Anle Cai, Zuhong Liu, Jian Peng
  Oncotarget.2017; 8(41): 70550.     CrossRef
• The role of SIRT1 in diabetic cardiomyopathy
  Hedyieh Karbasforooshan, Gholamreza Karimi
  Biomedicine & Pharmacotherapy.2017; 90: 386.     CrossRef
• Long-term obestatin treatment of mice type 2 diabetes increases insulin sensitivity and improves liver function
  Paweł A. Kołodziejski, Ewa Pruszyńska-Oszmałek, Mathias Z. Strowski, Krzysztof W. Nowak
  Endocrine.2017; 56(3): 538.     CrossRef
• Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic β cells from apoptosis
  Tingting Hu, Ye Chen, Qian Jiang, Jun Lin, Hewei Li, Ping Wang, Leping Feng
  Experimental and Therapeutic Medicine.2017; 14(2): 1727.     CrossRef
• Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1
  Ming‑Ming Cao, Xi Lu, Guo‑Dong Liu, Ying Su, Yan‑Bo Li, Jin Zhou
  Experimental and Therapeutic Medicine.2017;[Epub]     CrossRef
• Resveratrol Improves Glycemic Control in Type 2 Diabetic Obese Mice by Regulating Glucose Transporter Expression in Skeletal Muscle and Liver
  Caio Yonamine, Erika Pinheiro-Machado, Maria Michalani, Ana Alves-Wagner, João Esteves, Helayne Freitas, Ubiratan Machado
  Molecules.2017; 22(7): 1180.     CrossRef
• Sleep restriction induced energy, methylation and lipogenesis metabolic switches in rat liver
  Arjun Sengupta, Seth D. Rhoades, Eun Ji Kim, Soumyashant Nayak, Gregory R. Grant, Peter Meerlo, Aalim M. Weljie
  The International Journal of Biochemistry & Cell Biology.2017; 93: 129.     CrossRef
• Natural mineral-rich water ingestion by ovariectomized fructose-fed Sprague-Dawley rats: effects on sirtuin 1 and glucocorticoid signaling pathways
  Jugal Kishore Das, Milton Severo, Cidália Dionísio Pereira, Emília Patrício, José Magalhães, Rosário Monteiro, Delminda Neves, Maria João Martins
  Menopause.2017; 24(5): 563.     CrossRef
• SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats
  Cheng-Hua Zhou, Ming-Xing Zhang, Sha-Sha Zhou, Huan Li, Jian Gao, Lei Du, Xiao-Xing Yin
  Pain.2017; 158(1): 130.     CrossRef
• MiR-34a contributes to diabetes-related cochlear hair cell apoptosis via SIRT1/HIF-1α signaling
  Ying Lin, Jinjin Shen, Danfeng Li, Jie Ming, Xiangyang Liu, Nana Zhang, Jingbo Lai, Min Shi, Qiuhe Ji, Ying Xing
  General and Comparative Endocrinology.2017; 246: 63.     CrossRef
• High glucose upregulates endothelin type B receptors in vascular smooth muscle cells via the downregulation of Sirt1
  Yan Lin, Yan Zhao, Enqi Liu
  International Journal of Molecular Medicine.2017;[Epub]     CrossRef
• Anti-diabetic Effects of Ethanol Extract from Bitter Melon in Mice Fed a High-fat Diet
  Nal Ae Yoon, Juyeong Park, Jiyeon Lee, Joo Yeon Jeong, Hyun-Kyu Kim, Hak Sung Lee, In Guk Hwang, Gu Seob Roh, Hyun Joon Kim, Gyeong Jae Cho, Wan Sung Choi, Dong Hoon Lee, Sang Soo Kang
  Development & Reproduction.2017; 21(3): 259.     CrossRef
• Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways
  Shpetim Karandrea, Huquan Yin, Xiaomei Liang, Angela L. Slitt, Emma A. Heart, Guillermo López Lluch
  PLOS ONE.2017; 12(9): e0185374.     CrossRef
• Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-κB activation
  L. Yu, J. F. Chen, X. Shuai, Y. Xu, Y. Ding, J. Zhang, W. Yang, X. Liang, D. Su, C. Yan
  Journal of Endocrinological Investigation.2016; 39(1): 83.     CrossRef
• Mir‐217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via Sirt1/HIF‐1α signaling pathway
  Ying Shao, Chuan Lv, Can Wu, Yuehong Zhou, Qiuyue Wang
  Diabetes/Metabolism Research and Reviews.2016; 32(6): 534.     CrossRef
• Energetic stress: The reciprocal relationship between energy availability and the stress response
  C.S. Harrell, C.F. Gillespie, G.N. Neigh
  Physiology & Behavior.2016; 166: 43.     CrossRef
• Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products
  Yunan Sun, Hui Zhou, Hongmei Zhu, Siu-wai Leung
  Scientific Reports.2016;[Epub]     CrossRef
• Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice
  Si-Young Cho, Juewon Kim, Ji Hae Lee, Ji Hyun Sim, Dong-Hyun Cho, Il-Hong Bae, Hyunbok Lee, Min A. Seol, Hyun Mu Shin, Tae-Joo Kim, Dae-Yong Kim, Su-Hyung Lee, Song Seok Shin, Sin-Hyeog Im, Hang-Rae Kim
  Scientific Reports.2016;[Epub]     CrossRef
• Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults
  Javier Angulo, Mariam El Assar, Leocadio Rodríguez-Mañas
  Molecular Aspects of Medicine.2016; 50: 1.     CrossRef
• Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat
  Liqun Ma, Rongguo Fu, Zhaoyang Duan, Jiamei Lu, Jie Gao, Lifang Tian, Zhian Lv, Zhao Chen, Jin Han, Lining Jia, Li Wang
  Pathology - Research and Practice.2016; 212(4): 310.     CrossRef
• The Ticking of the Epigenetic Clock: Antipsychotic Drugs in Old Age
  Adonis Sfera, Carolina Osorio, Luzmin Inderias, Michael Cummings
  Frontiers in Endocrinology.2016;[Epub]     CrossRef
• ZLN005 protects cardiomyocytes against high glucose-induced cytotoxicity by promoting SIRT1 expression and autophagy
  Wenju Li, Xiaoli Li, Bin Wang, Yan Chen, Aiping Xiao, Di Zeng, Dongbo Ou, Song Yan, Wei Li, Qiangsun Zheng
  Experimental Cell Research.2016; 345(1): 25.     CrossRef
• How much successful are the medicinal chemists in modulation of SIRT1: A critical review
  Ashwani Kumar, Shilpi Chauhan
  European Journal of Medicinal Chemistry.2016; 119: 45.     CrossRef
• Network Based Approach in the Establishment of the Relationship between Type 2 Diabetes Mellitus and Its Complications at the Molecular Level Coupled with Molecular Docking Mechanism
  Shailima Rampogu, Mary Rampogu Lemuel
  BioMed Research International.2016; 2016: 1.     CrossRef
• 1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells
  Sergio Valente, Paolo Mellini, Francesco Spallotta, Vincenzo Carafa, Angela Nebbioso, Lucia Polletta, Ilaria Carnevale, Serena Saladini, Daniela Trisciuoglio, Chiara Gabellini, Maria Tardugno, Clemens Zwergel, Chiara Cencioni, Sandra Atlante, Sébastien Mo
  Journal of Medicinal Chemistry.2016; 59(4): 1471.     CrossRef
• Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility
  Omolola R. Oyenihi, Ayodeji B. Oyenihi, Anne A. Adeyanju, Oluwafemi O. Oguntibeju
  Journal of Diabetes Research.2016; 2016: 1.     CrossRef
• Mechanism of uncoupling protein 2-mediated myocardial injury in hypothermic preserved rat hearts
  Gai-Ge Chen, Jin-Bin Yan, Xu-Ming Wang, Ming-Zhi Zheng, Jian-Ping Jiang, Xin-Mei Zhou, Bin Cai, Yue-Liang Shen
  Molecular Medicine Reports.2016; 14(2): 1857.     CrossRef
• Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars
  Xiao‐Zhi Bai, Jia‐Qi Liu, Long‐Long Yang, Lei Fan, Ting He, Lin‐Lin Su, Ji‐Hong Shi, Chao‐Wu Tang, Zhao Zheng, Da‐Hai Hu
  British Journal of Pharmacology.2016; 173(10): 1589.     CrossRef
• Physiological regulation of the heat shock response by glutamine: implications for chronic low-grade inflammatory diseases in age-related conditions
  Jaqueline Santos Moreira Leite, Vinicius Fernandes Cruzat, Mauricio Krause, Paulo Ivo Homem de Bittencourt
  Nutrire.2016;[Epub]     CrossRef
• In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions
  Yuanmin Li, Jing Ni, Rong Guo, Weiming Li
  BioMed Research International.2016; 2016: 1.     CrossRef
• The role of bile acids in metabolic regulation
  Libor Vítek, Martin Haluzík
  Journal of Endocrinology.2016; 228(3): R85.     CrossRef
• New perspectives on the development of antiobesity drugs
  Luca Costantino, Daniela Barlocco
  Future Medicinal Chemistry.2015; 7(3): 315.     CrossRef
• SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
  Mingge Ding, Jingyi Lei, Hongcheng Han, Weibo Li, Yinxian Qu, Enqing Fu, Feng Fu, Xiaoming Wang
  Cardiovascular Diabetology.2015;[Epub]     CrossRef
• Resveratrol and diabetes: from animal to human studies
  Tomasz Szkudelski, Katarzyna Szkudelska
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2015; 1852(6): 1145.     CrossRef
• Resveratrol restores the circadian rhythmic disorder of lipid metabolism induced by high-fat diet in mice
  Linjie Sun, Yan Wang, Yu Song, Xiang-Rong Cheng, Shufang Xia, Md Ramim Tanver Rahman, Yonghui Shi, Guowei Le
  Biochemical and Biophysical Research Communications.2015; 458(1): 86.     CrossRef
• DPP‐4 Inhibitor Linagliptin Attenuates Aβ‐induced Cytotoxicity through Activation of AMPK in Neuronal Cells
  Edy Kornelius, Chih‐Li Lin, Hsiu‐Han Chang, Hsin‐Hua Li, Wen‐Nung Huang, Yi‐Sun Yang, Ying‐Li Lu, Chiung‐Huei Peng, Chien‐Ning Huang
  CNS Neuroscience & Therapeutics.2015; 21(7): 549.     CrossRef
• Effects of Caloric Intake on Learning and Memory Function in Juvenile C57BL/6J Mice
  Bao-Lei Xu, Rong Wang, Li-Na Ma, Wen Dong, Zhi-Wei Zhao, Jing-Shuang Zhang, Yu-Lan Wang, Xu Zhang
  BioMed Research International.2015; 2015: 1.     CrossRef
• Inhibition of microRNA-9-3p reduces lipid accumulation in HepG2 cells by targeting the expression of sirtuin type 1
  YA-NAN SUN, SI LI, YUN-TAO ZHOU, JIA LIU, LUO-BING TIAN, YAN-FENG ZHEN, HUI FANG
  Molecular Medicine Reports.2015; 12(5): 7742.     CrossRef
• Bioinformatics analysis of abnormal DNA methylation in muscle samples from monozygotic twins discordant for type 2 diabetes
  FEI LIU, QIANQIAN SUN, LINGXIAO WANG, SHUANGSHUANG NIE, JUN LI
  Molecular Medicine Reports.2015; 12(1): 351.     CrossRef
• Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo
  An-Sheng Cheng, Yu-Hsiang Cheng, Chi-Ying Lee, Chin-Yuan Chung, Wen-Chang Chang
  Nutrients.2015; 7(4): 2850.     CrossRef
• Ameliorative effects of lutein on non-alcoholic fatty liver disease in rats
  Xiang Qiu
  World Journal of Gastroenterology.2015; 21(26): 8061.     CrossRef
• Histone hypoacetylation and increased histone deacetylases in peripheral blood mononuclear cells from patients with Graves' disease
  Ni Yan, Jiao-zhen Zhou, Jin-an Zhang, Tiantian Cai, Wen Zhang, Yuan Wang, Fatuma-Said Muhali, Lijuan Guan, Rong-hua Song
  Molecular and Cellular Endocrinology.2015; 414: 143.     CrossRef
• Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1
  Zhuangzhi Meng, Jianguo Li, Honglin Zhao, Haiying Liu, Guowei Zhang, Lingzhan Wang, He Hu, Di Li, Mingjing Liu, Fulong Bi, Xiaoping Wang, Geng Tian, Qiang Liu, Batu Buren
  Experimental and Therapeutic Medicine.2015;[Epub]     CrossRef
• Could changes in adiponectin drive the effect of statins on the risk of new-onset diabetes? The case of pitavastatin
  Lorenzo Arnaboldi, Alberto Corsini
  Atherosclerosis Supplements.2015; 16: 1.     CrossRef
• Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation
  Chun-Jung Huang, Matthew J. McAllister, Aaron L. Slusher, Heather E. Webb, J. Thomas Mock, Edmund O. Acevedo
  Sports Medicine - Open.2015;[Epub]     CrossRef
• SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism
  Rong Guo, Weijing Liu, Baoxin Liu, Buchun Zhang, Weiming Li, Yawei Xu
  International Journal of Cardiology.2015; 191: 36.     CrossRef
• Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis
  Mohamed H. Noureldein, Rania S. Abd El-Razek, Mohamed H. El-Hefnawy, Hala O. El-Mesallamy
  Diabetes Research and Clinical Practice.2015; 109(3): 513.     CrossRef
• Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients
  Stefania Mariani, Daniela Fiore, Sabrina Basciani, Agnese Persichetti, Savina Contini, Carla Lubrano, Luisa Salvatori, Andrea Lenzi, Lucio Gnessi
  Endocrine.2015; 49(3): 711.     CrossRef
• Platycodon grandiflorum A. De Candolle Ethanolic Extract Inhibits Adipogenic Regulators in 3T3-L1 Cells and Induces Mitochondrial Biogenesis in Primary Brown Preadipocytes
  Hye-Lin Kim, Jinbong Park, Hyewon Park, Yunu Jung, Dong-Hyun Youn, JongWook Kang, Mi-Young Jeong, Jae-Young Um
  Journal of Agricultural and Food Chemistry.2015; 63(35): 7721.     CrossRef
• Amazonian Fruits: An Overview of Nutrients, Calories and Use in Metabolic Disorders
  Moacir Couto de Andrade Júnior, Jerusa Souza Andrade
  Food and Nutrition Sciences.2014; 05(17): 1692.     CrossRef
• Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway
  Jing Feng, Shuai Liu, Sai Ma, Jian Zhao, Wei Zhang, Wei Qi, Pengchong Cao, Zheng Wang, Wei Lei
  Acta Biochimica et Biophysica Sinica.2014; 46(12): 1024.     CrossRef
• The fat cell senescence hypothesis
  Philip Newsholme, Paulo I. Homem de Bittencourt
  Current Opinion in Clinical Nutrition and Metabolic Care.2014; 17(4): 295.     CrossRef
• Sirt1 and Sirt6 Mediate Beneficial Effects of Rosiglitazone on Hepatic Lipid Accumulation
  Soo Jin Yang, Jung Mook Choi, Eugene Chang, Sung Woo Park, Cheol-Young Park, Aimin Xu
  PLoS ONE.2014; 9(8): e105456.     CrossRef
• Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation
  Soo Jin Yang, Yunsook Lim
  Metabolism.2014; 63(5): 693.     CrossRef
• Role of SIRT1 in Streptococcus pneumoniae-induced human β-defensin-2 and interleukin-8 expression in A549 cell
  Li Lin, Shun-hang Wen, Shu-zhen Guo, Xiao-yan Su, Hu-jun Wu, Lei Chong, Hai-lin Zhang, Wei-xi Zhang, Chang-chong Li
  Molecular and Cellular Biochemistry.2014; 394(1-2): 199.     CrossRef

Since the mitochondrial pyruvate dehydrogenase complex (PDC) controls the rate of carbohydrate oxidation, impairment of PDC activity mediated by high-fat intake has been advocated as a causative factor for the skeletal muscle insulin resistance, metabolic syndrome, and the onset of type 2 diabetes (T2D). There are also situations where muscle insulin resistance can occur independently from high-fat dietary intake such as sepsis, inflammation, or drug administration though they all may share the same underlying mechanism, i.e., via activation of forkhead box family of transcription factors, and to a lower extent via peroxisome proliferator-activated receptors. The main feature of T2D is a chronic elevation in blood glucose levels. Chronic systemic hyperglycaemia is toxic and can lead to cellular dysfunction that may become irreversible over time due to deterioration of the pericyte cell's ability to provide vascular stability and control to endothelial proliferation. Therefore, it may not be surprising that T2D's complications are mainly macrovascular and microvascular related, i.e., neuropathy, retinopathy, nephropathy, coronary artery, and peripheral vascular diseases. However, life style intervention such as exercise, which is the most potent physiological activator of muscle PDC, along with pharmacological intervention such as administration of dichloroacetate or L-carnitine can prove to be viable strategies for treating muscle insulin resistance in obesity and T2D as they can potentially restore whole body glucose disposal.

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Citations to this article as recorded by  

• Oxidative stress and metabolism meet epigenetic modulation in physical exercise
  José Luis García-Giménez, Irene Cánovas-Cervera, Federico V. Pallardó
  Free Radical Biology and Medicine.2024; 213: 123.     CrossRef
• The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
  Peter W. Stacpoole, Charles E. McCall
  Mitochondrion.2023; 70: 59.     CrossRef
• Regulating mitochondrial metabolism by targeting pyruvate dehydrogenase with dichloroacetate, a metabolic messenger
  Nick Schoenmann, Nicholas Tannenbaum, Ryan M. Hodgeman, Raghavan Pillai Raju
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(7): 166769.     CrossRef
• Serum metabolomics profiling by proton nuclear magnetic resonance spectrometry of the response to single oral macronutrient challenges in women with polycystic ovary syndrome (PCOS) compared with male and female controls
  Héctor F. Escobar-Morreale, María Ángeles Martínez-García, María Insenser, Nicolau Cañellas, Xavier Correig, Manuel Luque-Ramírez
  Biology of Sex Differences.2023;[Epub]     CrossRef
• Metabolomics and mitochondrial dysfunction in cardiometabolic disease
  Abhishek Shastry, Kimberly Dunham-Snary
  Life Sciences.2023; 333: 122137.     CrossRef
• Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases
  Jae‐Han Jeon, Themis Thoudam, Eun Jung Choi, Min‐Ji Kim, Robert A Harris, In‐Kyu Lee
  Journal of Diabetes Investigation.2021; 12(1): 21.     CrossRef
• Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy
  Saleha Anwar, Anas Shamsi, Taj Mohammad, Asimul Islam, Md. Imtaiyaz Hassan
  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2021; 1876(1): 188568.     CrossRef
• Effect of exercise training on skeletal muscle protein expression in relation to insulin sensitivity: Per‐protocol analysis of a randomized controlled trial (GO‐ACTIWE)
  Lea Bruhn, Rasmus Kjøbsted, Jonas Salling Quist, Anne Sofie Gram, Mads Rosenkilde, Kristine Færch, Jørgen F.P. Wojtaszewski, Bente Stallknecht, Martin Bæk Blond
  Physiological Reports.2021;[Epub]     CrossRef
• The Mechanism behind Influenza Virus Cytokine Storm
  Yinuo Gu, Xu Zuo, Siyu Zhang, Zhuoer Ouyang, Shengyu Jiang, Fang Wang, Guoqiang Wang
  Viruses.2021; 13(7): 1362.     CrossRef
• Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α
  Nives Škorja Milić, Klemen Dolinar, Katarina Miš, Urška Matkovič, Maruša Bizjak, Mojca Pavlin, Matej Podbregar, Sergej Pirkmajer
  International Journal of Molecular Sciences.2021; 22(16): 8610.     CrossRef
• The Regulatory Roles of PPARs in Skeletal Muscle Fuel Metabolism and Inflammation: Impact of PPAR Agonism on Muscle in Chronic Disease, Contraction and Sepsis
  Hannah Crossland, Dumitru Constantin-Teodosiu, Paul L. Greenhaff
  International Journal of Molecular Sciences.2021; 22(18): 9775.     CrossRef
• PPARα, δ and FOXO1 Gene Silencing Overturns Palmitate-Induced Inhibition of Pyruvate Oxidation Differentially in C2C12 Myotubes
  Hung-Che Chien, Despina Constantin, Paul L. Greenhaff, Dumitru Constantin-Teodosiu
  Biology.2021; 10(11): 1098.     CrossRef
• Molecular Mechanisms of Muscle Fatigue
  Dumitru Constantin-Teodosiu, Despina Constantin
  International Journal of Molecular Sciences.2021; 22(21): 11587.     CrossRef
• Coronavirus Disease-19 (COVID-19) and Modern Lifestyle Diseases
  Pallav Sengupta, Sulagna Dutta
  Biomedical and Pharmacology Journal.2021; 14(4): 2245.     CrossRef
• A single bout of resistance exercise improves postprandial lipid metabolism in overweight/obese men with prediabetes
  Adam J. Bittel, Daniel C. Bittel, Bettina Mittendorfer, Bruce W. Patterson, Adewole L. Okunade, Jun Yoshino, Lane C. Porter, Nada A. Abumrad, Dominic N. Reeds, W. Todd Cade
  Diabetologia.2020; 63(3): 611.     CrossRef
• An integrative approach to the regulation of mitochondrial respiration during exercise: Focus on high-intensity exercise
  Jose A.L. Calbet, Saúl Martín-Rodríguez, Marcos Martin-Rincon, David Morales-Alamo
  Redox Biology.2020; 35: 101478.     CrossRef
• PPARδ and FOXO1 Mediate Palmitate-Induced Inhibition of Muscle Pyruvate Dehydrogenase Complex and CHO Oxidation, Events Reversed by Electrical Pulse Stimulation
  Hung-Che Chien, Paul L. Greenhaff, Dumitru Constantin-Teodosiu
  International Journal of Molecular Sciences.2020; 21(16): 5942.     CrossRef
• Cancer cachexia has many symptoms but only one cause: anoxia
  Tomas Koltai
  F1000Research.2020; 9: 250.     CrossRef
• Structural basis for the inhibition of PDK2 by novel ATP- and lipoyl-binding site targeting compounds
  Jihoon Kang, Haushabhau S. Pagire, Donguk Kang, Yo Han Song, In Kyu Lee, Kang Taek Lee, Chin-Ju Park, Jin Hee Ahn, Jungwook Kim
  Biochemical and Biophysical Research Communications.2020; 527(3): 778.     CrossRef
• Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic
  Livio Luzi, Maria Grazia Radaelli
  Acta Diabetologica.2020; 57(6): 759.     CrossRef
• Changes in gene expression of lactate carriers (MCT1 and CD147) in cardiac muscle of diabetic male rats: the effect of dichloroacetate and endurance training
  H. Rezaeinasab, A. Habibi, M. Nikbakht, M. Rashno, S. Shakerian
  The Ukrainian Biochemical Journal.2020; 92(5): 111.     CrossRef
• Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation
  Haowen Jiang, Jia Jin, Yanan Duan, Zhifu Xie, Yufeng Li, Anhui Gao, Min Gu, Xinwen Zhang, Chang Peng, Chunmei Xia, Tiancheng Dong, Hui Li, Lifang Yu, Jie Tang, Fan Yang, Jingya Li, Jia Li
  Diabetes.2019; 68(12): 2197.     CrossRef
• Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Induced by Repeated Forced Swimming in Mice
  Takuya Ohba, Shinichi Domoto, Miyu Tanaka, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara
  Biological and Pharmaceutical Bulletin.2019; 42(7): 1140.     CrossRef
• The Beta Cell in Type 2 Diabetes
  Ashley A. Christensen, Maureen Gannon
  Current Diabetes Reports.2019;[Epub]     CrossRef
• Reduced expression of Twist 1 is protective against insulin resistance of adipocytes and involves mitochondrial dysfunction
  Sumei Lu, Hong Wang, Rui Ren, Xiaohong Shi, Yanmei Zhang, Wanshan Ma
  Scientific Reports.2018;[Epub]     CrossRef
• PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels
  Bo-Yoon Park, Jae-Han Jeon, Younghoon Go, Hye Jin Ham, Jeong-Eun Kim, Eun Kyung Yoo, Woong Hee Kwon, Nam-Ho Jeoung, Yong Hyun Jeon, Seung-Hoi Koo, Byung-Gyu Kim, Ling He, Keun-Gyu Park, Robert A. Harris, In-Kyu Lee
  Diabetes.2018; 67(10): 2054.     CrossRef
• Differences in Muscle Metabolism Between Triathletes and Normally Active Volunteers Investigated Using Multinuclear Magnetic Resonance Spectroscopy at 7T
  Radka Klepochová, Ladislav Valkovič, Thomas Hochwartner, Christoph Triska, Norbert Bachl, Harald Tschan, Siegfried Trattnig, Michael Krebs, Martin Krššák
  Frontiers in Physiology.2018;[Epub]     CrossRef
• Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action
  Kristoffer Svensson, Jessica R. Dent, Shahriar Tahvilian, Vitor F. Martins, Abha Sathe, Julien Ochala, Mulchand S. Patel, Simon Schenk
  American Journal of Physiology-Endocrinology and Metabolism.2018; 315(5): E1034.     CrossRef
• Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism
  María Isabel Hernández-Alvarez, Angels Díaz-Ramos, María Berdasco, Jeff Cobb, Evarist Planet, Diane Cooper, Agnieszka Pazderska, Krzystof Wanic, Declan O’Hanlon, Antonio Gomez, Laura R. de la Ballina, Manel Esteller, Manuel Palacin, Donal J. O’Gorman, Joh
  Scientific Reports.2017;[Epub]     CrossRef
• Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
  Peter W Stacpoole
  JNCI: Journal of the National Cancer Institute.2017;[Epub]     CrossRef
• Hyperpalatable Diet and Physical Exercise Modulate the Expression of the Glial Monocarboxylate Transporters MCT1 and 4
  Luis V. Portela, Andressa W. Brochier, Clarissa B. Haas, Afonso Kopczynski de Carvalho, Jussania A. Gnoato, Eduardo R. Zimmer, Eduardo Kalinine, Luc Pellerin, Alexandre P. Muller
  Molecular Neurobiology.2017; 54(8): 5807.     CrossRef
• Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock
  Kumar Subramani, Sumin Lu, Marie Warren, Xiaogang Chu, Haroldo A. Toque, R. William Caldwell, Michael P. Diamond, Raghavan Raju
  Scientific Reports.2017;[Epub]     CrossRef
• The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate‐intensity exercise in human skeletal muscle
  A. Vigelsø, M. Gram, R. Dybboe, A. B. Kuhlman, C. Prats, P. L. Greenhaff, D. Constantin‐Teodosiu, J. B. Birk, J. F. P. Wojtaszewski, F. Dela, J. W. Helge
  The Journal of Physiology.2016; 594(8): 2339.     CrossRef
• Global Kinetic Analysis of Mammalian E3 Reveals pH-dependent NAD+/NADH Regulation, Physiological Kinetic Reversibility, and Catalytic Optimum
  Michael A. Moxley, Daniel A. Beard, Jason N. Bazil
  Journal of Biological Chemistry.2016; 291(6): 2712.     CrossRef
• Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
  Gwon-Soo Jung, Jae-Han Jeon, Yeon-Kyung Choi, Se Young Jang, Soo Young Park, Sung-Woo Kim, Jun-Kyu Byun, Mi-Kyung Kim, Sungwoo Lee, Eui-Cheol Shin, In-Kyu Lee, Yu Na Kang, Keun-Gyu Park
  Scientific Reports.2016;[Epub]     CrossRef
• Altered heart proteome in fructose-fed Fisher 344 rats exposed to bisphenol A
  S.A. Ljunggren, M. Iggland, M. Rönn, L. Lind, P.M. Lind, H. Karlsson
  Toxicology.2016; 347-349: 6.     CrossRef
• Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice
  Bjorn T. Tam, Xiao M. Pei, Benjamin Y. Yung, Shea P. Yip, Lawrence W. Chan, Cesar S. Wong, Parco M. Siu
  Pflügers Archiv - European Journal of Physiology.2015; 467(12): 2555.     CrossRef
• Sex-related differences in the effects of high-fat diets on DHEA-treated rats
  Ana Lúcia Cecconello, Marcia Trapp, Ana Lúcia Hoefel, Cláudia Vieira Marques, Bruno Dutra Arbo, Gabriela Osterkamp, Luiz Carlos Rios Kucharski, Maria Flávia Marques Ribeiro
  Endocrine.2015; 48(3): 985.     CrossRef
• Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle
  Sergio Arrabal, Miguel Angel Lucena, Miren Josune Canduela, Almudena Ramos-Uriarte, Patricia Rivera, Antonia Serrano, Francisco Javier Pavón, Juan Decara, Antonio Vargas, Elena Baixeras, Mercedes Martín-Rufián, Javier Márquez, Pedro Fernández-Llébrez, Bau
  PLOS ONE.2015; 10(12): e0145244.     CrossRef
• A glance at … exercise and glucose uptake
  Michael J. Glade, Kyl Smith
  Nutrition.2015; 31(6): 893.     CrossRef
• Perpetual muscle PDH activation in PDH kinase knockout mice protects against high-fat feeding–induced muscle insulin resistance
  Dumitru Constantin-Teodosiu, Francis B. Stephens, Paul L. Greenhaff
  Proceedings of the National Academy of Sciences.2015;[Epub]     CrossRef
• Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content
  Craig A. Goodman, Derk Pol, Evelyn Zacharewicz, Robert S. Lee-Young, Rod J. Snow, Aaron P. Russell, Glenn K. McConell, Ashok Kumar
  PLOS ONE.2015; 10(5): e0128398.     CrossRef
• 13C metabolic flux analysis shows that resistin impairs the metabolic response to insulin in L6E9 myotubes
  Shirley Guzmán, Silvia Marin, Anibal Miranda, Vitaly A Selivanov, Josep J Centelles, Romain Harmancey, Fatima Smih, Annie Turkieh, Yves Durocher, Antonio Zorzano, Philippe Rouet, Marta Cascante
  BMC Systems Biology.2014;[Epub]     CrossRef
• Translational Research: From Biological Discovery to Public Benefit (or Not)
  Michael R. Emmert-Buck
  Advances in Biology.2014; 2014: 1.     CrossRef
• Diabetic Worker with History of Falls: A Case Study
  Ann R. Lurati
  Workplace Health & Safety.2014; 62(5): 175.     CrossRef
• Diabetic Worker With History of Falls: A Case Study
  Ann R. Lurati
  Workplace Health & Safety.2014; 62(5): 175.     CrossRef
• Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion
  Patrick A. Vigueira, Kyle S. McCommis, George G. Schweitzer, Maria S. Remedi, Kari T. Chambers, Xiaorong Fu, William G. McDonald, Serena L. Cole, Jerry R. Colca, Rolf F. Kletzien, Shawn C. Burgess, Brian N. Finck
  Cell Reports.2014; 7(6): 2042.     CrossRef

There are many studies on the prevalence, clinical characteristics, and economic burden of diabetes across the past four decades in Korea. Nonetheless, there is a dearth of nationwide study regarding diabetes encompassing all age group. Eight years ago, the Committee on the Epidemiology of Diabetes Mellitus of Korean Diabetes Association collaborated with Health Insurance Review & Assessment Service to evaluate the status of diabetes care and characteristics in diabetic patients in Korea. In 2007, the collaborative task force team published a comprehensive survey titled "Diabetes in Korea 2007." In this review, we reappraise the diabetic epidemics from the joint report and suggest further studies that are needed to be investigated in the future.

Citations

Citations to this article as recorded by  

• Revisiting the Diabetes Crisis in Korea: Call for Urgent Action
  Jun Sung Moon
  The Journal of Korean Diabetes.2023; 24(1): 1.     CrossRef
• Risk assessment and classification for foot ulceration among patients with type 2 diabetes in South Korea
  Eun Joo Lee, Ihn Sook Jeong, In Ju Kim, Young Hye Cho, Yun Jin Kim
  International Journal of Nursing Practice.2022;[Epub]     CrossRef
• Using real-world data for supporting regulatory decision making: Comparison of cardiovascular and safety outcomes of an empagliflozin randomized clinical trial versus real-world data
  Ha Young Jang, In-Wha Kim, Jung Mi Oh
  Frontiers in Pharmacology.2022;[Epub]     CrossRef
• Differences in health behavior and nutrient intake status between diabetes-aware and unaware Korean adults based on the Korea national health and nutrition examination survey 2016–18 data: A cross-sectional study
  Anshul Sharma, Chen Lulu, Kee-Ho Song, Hae-Jeung Lee
  Frontiers in Public Health.2022;[Epub]     CrossRef
• Do statins benefit low-risk population for primary prevention of atherosclerotic cardiovascular disease: A retrospective cohort study
  In Sun Ryou, Ju Young Kim, Hwa Yeon Park, Sohee Oh, Sehun Kim, Hwa Jung Kim
  Frontiers in Medicine.2022;[Epub]     CrossRef
• Association between oseltamivir use and neuropsychiatric adverse events in influenza patients: a nationwide population-based cohort study
  Hye-Rim Kang, Suk-Chan Jang, Ju-Young Shin
  Expert Opinion on Drug Safety.2021; 20(2): 245.     CrossRef
• Effectiveness and safety of sodium‐glucose co‐transporter‐2 inhibitors compared with dipeptidyl peptidase‐4 inhibitors in older adults with type 2 diabetes: A nationwide population‐based study
  Seung Jin Han, Kyoung Hwa Ha, Nami Lee, Dae Jung Kim
  Diabetes, Obesity and Metabolism.2021; 23(3): 682.     CrossRef
• Cost-Effectiveness of Tiotropium in Elderly Patients with Severe Asthma Using Real-World Data
  Sung-Hyun Hong, Jeong-Yeon Cho, Tae-Bum Kim, Eui-Kyung Lee, Sun-Hong Kwon, Ju-Young Shin
  The Journal of Allergy and Clinical Immunology: In Practice.2021; 9(5): 1939.     CrossRef
• Dapagliflozin improves cardiovascular risk factors in Emirati patients with T2DM
  Aml Mohamed Nada, Mariam Adel Younan
  Therapeutic Advances in Endocrinology and Metabolism.2021; 12: 204201882199536.     CrossRef
• Association between socioeconomic position and diabetic foot ulcer outcomes: a population-based cohort study in South Korea
  Jeong Hyun Ha, Heejin Jin, Ji-Ung Park
  BMC Public Health.2021;[Epub]     CrossRef
• Etiology, diagnosis, complications, and treatments of diabetic foot
  Dong-Kyo Seo
  Journal of the Korean Medical Association.2021; 64(8): 523.     CrossRef
• Hospital admissions due to endocrine diseases in Korean male firefighters
  Seunghoon Ryu, Yong-Jin Lee, Eun-Chul Jang, Soon-Chan Kwon, KiSeok Kim, Yeon-Soon Ahn, Young-Sun Min
  Annals of Occupational and Environmental Medicine.2021;[Epub]     CrossRef
• Association between Frequency of Breakfast Consumption and Insulin Resistance Using Triglyceride-Glucose Index: A Cross-Sectional Study of the Korea National Health and Nutrition Examination Survey (2016–2018)
  Hye Jin Joo, Gyu Ri Kim, Eun-Cheol Park, Sung-In Jang
  International Journal of Environmental Research and Public Health.2020; 17(9): 3322.     CrossRef
• Review of Diabetic Foot Complication Assessment Tools Developed from 2007 to 2016
  Yoonhee Lee, Youngshin Song
  Journal of Korean Academy of Fundamentals of Nursing.2019; 26(4): 231.     CrossRef
• Associations between Breastfeeding and Type 2 Diabetes Mellitus and Glycemic Control in Parous Women: A Nationwide, Population-Based Study
  Ga Eun Nam, Kyungdo Han, Do-Hoon Kim, Youn Huh, Byoungduck Han, Sung Jung Cho, Yong Gyu Park, Yong-Moon Park
  Diabetes & Metabolism Journal.2019; 43(2): 236.     CrossRef
• Risk of osteoporosis in patients with chronic inflammatory neuropathy- a population-based cohort study
  Seung Woo Kim, Eun Hwa Kim, Jinae Lee, Young-Chul Choi, Seung Min Kim, Ha Young Shin
  Scientific Reports.2019;[Epub]     CrossRef
• Differences in the risk of mood disorders in patients with asthma-COPD overlap and in patients with COPD alone: a nationwide population-based retrospective cohort study in Korea
  Hye-Rim Kang, Sung-Hyun Hong, So-Young Ha, Tae-Bum Kim, Eui-Kyung Lee
  Respiratory Research.2019;[Epub]     CrossRef
• A Comparison of Leukotriene Receptor Antagonists to Low-Dose Inhaled Corticosteroids in the Elderly with Mild Asthma
  Sung-Hyun Hong, Hye-Rim Kang, Jin Hyun Nam, Sun-Kyeong Park, Tae-Bum Kim, Eui-Kyung Lee
  The Journal of Allergy and Clinical Immunology: In Practice.2019; 7(8): 2642.     CrossRef
• The Need to Improve the Quality of Diabetes Care in Korea
  Seung Jin Han, Dae Jung Kim
  Journal of Korean Medical Science.2019;[Epub]     CrossRef
• Fifty Years of Compassionate Care and Harmonious Collaboration of the Korean Diabetes Association: The 50th Anniversary of Korean Diabetes Association
  Jong Chul Won, Eun-Jung Rhee, Hyung Joon Yoo
  Diabetes & Metabolism Journal.2018; 42(6): 475.     CrossRef
• Depth and combined infection is important predictor of lower extremity amputations in hospitalized diabetic foot ulcer patients
  Eun-Gyo Jeong, Sung Shim Cho, Sang-Hoon Lee, Kang-Min Lee, Seo-Kyung Woo, Yoongoo Kang, Jae-Seung Yun, Seon-Ah Cha, Yoon-Jung Kim, Yu-Bae Ahn, Seung-Hyun Ko, Jung-Min Lee
  The Korean Journal of Internal Medicine.2018; 33(5): 952.     CrossRef
• Favorable glycemic response after pancreatoduodenectomy in both patients with pancreatic cancer and patients with non-pancreatic cancer
  Seo Young Sohn, Eun Kyung Lee, Sung-Sik Han, You Jin Lee, Yul Hwangbo, Young Hwa Kang, Seung Duk Lee, Seong Hoon Kim, Sang Myung Woo, Woo Jin Lee, Eun Kyung Hong, Sang-Jae Park
  Medicine.2018; 97(18): e0590.     CrossRef
• Clinical Importance of Diabetic Neuropathy
  Tae Sun Park
  The Journal of Korean Diabetes.2018; 19(3): 147.     CrossRef
• Women are less likely than men to achieve optimal glycemic control after 1 year of treatment: A multi-level analysis of a Korean primary care cohort
  Seung-Ah Choe, Joo Yeong Kim, Young Sun Ro, Sung-Il Cho, Antonio Palazón-Bru
  PLOS ONE.2018; 13(5): e0196719.     CrossRef
• Diagnosis and Management of Diabetic Foot
  Chang Won Lee
  The Journal of Korean Diabetes.2018; 19(3): 168.     CrossRef
• HbA1c Cutoff for Prediabetes and Diabetes Based on Oral Glucose Tolerance Test in Obese Children and Adolescents
  Hyo-Kyoung Nam, Won Kyoung Cho, Jae Hyun Kim, Young-Jun Rhie, Sochung Chung, Kee-Hyoung Lee, Byung-Kyu Suh
  Journal of Korean Medical Science.2018;[Epub]     CrossRef
• Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
  Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
  Diabetes & Metabolism Journal.2018; 42(5): 415.     CrossRef
• Risk factors of asthma exacerbation based on asthma severity: a nationwide population-based observational study in South Korea
  Hye-Rim Kang, Hyun Jin Song, Jin Hyun Nam, Sung-Hyun Hong, So-Young Yang, SangEun Ju, Sang Won Lee, Tae-Bum Kim, Hye-Lin Kim, Eui-Kyung Lee
  BMJ Open.2018; 8(3): e020825.     CrossRef
• Foot Care for Diabetic Patients
  Hye Jung Cha
  The Journal of Korean Diabetes.2018; 19(1): 41.     CrossRef
• Risk of new-onset diabetes among patients treated with statins according to hypertension and gender: Results from a nationwide health-screening cohort
  Sang-Eun Lee, Ji Min Sung, In-Jeong Cho, Hyeon Chang Kim, Hyuk-Jae Chang, Lamberto Manzoli
  PLOS ONE.2018; 13(4): e0195459.     CrossRef
• Treatment variation related to comorbidity and complications in type 2 diabetes
  Yeon Young Cho, Sung-il Cho
  Medicine.2018; 97(37): e12435.     CrossRef
• Efficacy of Body Weight Reduction on the SGLT2 Inhibitor in People with Type 2 Diabetes Mellitus
  Hyun A Cho, Young Lee Jung, Yong Hoon Lee, Yu Chang Lee, Jung Eun Lee, Sol Jae Lee, Su Jin Jeong, Chong Hwa Kim
  Journal of Obesity & Metabolic Syndrome.2017; 26(2): 107.     CrossRef
• Physician-Directed Diabetes Education without a Medication Change and Associated Patient Outcomes
  Hun-Sung Kim, Hyunah Kim, Hae-Kyung Yang, Eun Young Lee, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung-Hwan Lee, Jae Hyoung Cho, In Young Choi, Hyeon Woo Yim, Bong-Yun Cha
  Diabetes & Metabolism Journal.2017; 41(3): 187.     CrossRef
• Current status of managing diabetes mellitus in Korea
  Kyoung Hwa Ha, Dae Jung Kim
  The Korean Journal of Internal Medicine.2016; 31(5): 845.     CrossRef
• 7^th Asian PAD Workshop
  
  Annals of Vascular Diseases.2016; 9(2): 135.     CrossRef
• Trends in Diabetes Incidence in the Last Decade Based on Korean National Health Insurance Claims Data
  Sun Ok Song, Yong-ho Lee, Dong Wook Kim, Young Duk Song, Joo Young Nam, Kyoung Hye Park, Dae Jung Kim, Seok Won Park, Hyun Chul Lee, Byung-Wan Lee
  Endocrinology and Metabolism.2016; 31(2): 292.     CrossRef
• Trends of antidiabetic drug use in adult type 2 diabetes in Korea in 2002–2013
  Seung-Hyun Ko, Dae-Jung Kim, Jong-Heon Park, Cheol-Young Park, Chang Hee Jung, Hyuk-Sang Kwon, Joong-Yeol Park, Kee-Ho Song, Kyungdo Han, Ki-Up Lee, Kyung-Soo Ko
  Medicine.2016; 95(27): e4018.     CrossRef
• Glycosylated Hemoglobin Threshold for Predicting Diabetes and Prediabetes from the Fifth Korea National Health and Nutrition Examination Survey
  Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Cheol-Young Park, Chang Beom Lee, Sung-Hee Ihm
  Diabetes & Metabolism Journal.2016; 40(2): 167.     CrossRef
• Predictive Value of Glucose Parameters Obtained From Oral Glucose Tolerance Tests in Identifying Individuals at High Risk for the Development of Diabetes in Korean Population
  Hae Kyung Yang, Hee-Sung Ha, Marie Rhee, Jin-Hee Lee, Yong-Moon Park, Hyuk-Sang Kwon, Hyeon-Woo Yim, Moo-Il Kang, Won-Chul Lee, Ho-Young Son, Seung-Hwan Lee, Kun-Ho Yoon
  Medicine.2016; 95(10): e3053.     CrossRef
• Serum preadipocyte factor 1 concentrations and risk of developing diabetes: a nested case–control study
  S. H. Lee, M. Rhee, H. K. Yang, H. S. Ha, J. H. Lee, H. S. Kwon, Y. M. Park, H. W. Yim, M. I. Kang, W. C. Lee, H. Y. Son, K. H. Yoon
  Diabetic Medicine.2016; 33(5): 631.     CrossRef
• Is an Oral Glucose Tolerance Test Still Valid for Diagnosing Diabetes Mellitus?
  Dong-Lim Kim, Sun-Doo Kim, Suk Kyeong Kim, Sooyoun Park, Kee-Ho Song
  Diabetes & Metabolism Journal.2016; 40(2): 118.     CrossRef
• Fasting plasma glucose concentrations for specified HbA1c goals in Korean populations: data from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2, 2011)
  Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Chang Beom Lee, Sung-Hee Ihm
  Diabetology & Metabolic Syndrome.2016;[Epub]     CrossRef
• Combined use of basal insulin analog and acarbose reduces postprandial glucose in patients with uncontrolled type 2 diabetes
  Ji‐Hyun Kim, Ji‐Hyun Ahn, Soo‐Kyung Kim, Dae‐Ho Lee, Hye‐Soon Kim, Ho‐Sang Shon, Hyun‐Jeong Jeon, Tae‐Hwa Kim, Yong‐Wook Cho, Jae‐Taek Kim, Sung‐Min Han, Choon‐Hee Chung, Ohk‐Hyun Ryu, Jae‐Min Lee, Soon‐Hee Lee, Min‐Jeong Kwon, Tae‐kyun Kim, Il‐Seong Namg
  Journal of Diabetes Investigation.2015; 6(2): 219.     CrossRef
• Anti-Oxidative and Anti-Diabetic Effects of Methanol Extracts from Medicinal Plants
  Youn Ri Lee, Nara Yoon
  Journal of the Korean Society of Food Science and Nutrition.2015; 44(5): 681.     CrossRef
• Associations Between the Continuity of Ambulatory Care of Adult Diabetes Patients in Korea and the Incidence of Macrovascular Complications
  Young-Hoon Gong, Seok-Jun Yoon, Hyeyoung Seo, Dongwoo Kim
  Journal of Preventive Medicine and Public Health.2015; 48(4): 188.     CrossRef
• Statin eligibility and cardiovascular risk burden assessed by coronary artery calcium score: Comparing the two guidelines in a large Korean cohort
  Eun-Jung Rhee, Se Eun Park, Hyung Geun Oh, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Ron Blankstein, Jorge Plutzky, Won-Young Lee
  Atherosclerosis.2015; 240(1): 242.     CrossRef
• Evaluation of low-dose aspirin for primary prevention of ischemic stroke among patients with diabetes: a retrospective cohort study
  Ye-Jee Kim, Nam-Kyong Choi, Mi-Sook Kim, Joongyub Lee, Yoosoo Chang, Jong-Mi Seong, Sun-Young Jung, Ju-Young Shin, Ji-Eun Park, Byung-Joo Park
  Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef
• Health-Related Quality of Life in Coronary Heart Disease in Korea
  Hyung Tak Lee, Jinho Shin, Young-Hyo Lim, Kyung Soo Kim, Soon Gil Kim, Jeong Hyun Kim, Heon Kil Lim
  Angiology.2015; 66(4): 326.     CrossRef
• Seroepidemiology of varicella-zoster virus in Korean adolescents and adults using fluorescent antibody to membrane antigen test
  S. B. HAN, K. R. KANG, D. H. HUH, H. C. LEE, J. H. KIM, J. H. KANG, S. H. MA
  Epidemiology and Infection.2015; 143(8): 1643.     CrossRef
• Changing Clinical Characteristics according to Insulin Resistance and Insulin Secretion in Newly Diagnosed Type 2 Diabetic Patients in Korea
  Jang Won Son, Cheol-Young Park, Sungrae Kim, Han-Kyu Lee, Yil-Seob Lee
  Diabetes & Metabolism Journal.2015; 39(5): 387.     CrossRef
• Age- and Sex-Specific Relationships between Household Income, Education, and Diabetes Mellitus in Korean Adults: The Korea National Health and Nutrition Examination Survey, 2008-2010
  So-Ra Kim, Kyungdo Han, Jin-Young Choi, Jennifer Ersek, Junxiu Liu, Sun-Jin Jo, Kang-Sook Lee, Hyeon Woo Yim, Won-Chul Lee, Yong Gyu Park, Seung-Hwan Lee, Yong-Moon Park, C. Mary Schooling
  PLOS ONE.2015; 10(1): e0117034.     CrossRef
• Association between Diabetes Education Status and Clinical Outcomes of Patients with Diabetes Mellitus: Analysis of the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V)
  Jun Sung Kwon, Won Jun Kim, Yang Hee Han, Hyun Joong Kim, Sa Young Shin, Kyoo Ho Choi, Jae Hyuck Jun, Myoung Sook Shim, Jin Yeob Kim
  The Journal of Korean Diabetes.2014; 15(4): 236.     CrossRef
• The Incidence and Prevalence of Diabetes Mellitus and Related Atherosclerotic Complications in Korea: A National Health Insurance Database Study
  Bo Kyung Koo, Chang-Hoon Lee, Bo Ram Yang, Seung-sik Hwang, Nam-Kyong Choi, Mohammad Ebrahim Khamseh
  PLoS ONE.2014; 9(10): e110650.     CrossRef
• Current Status of Glycemic Control of Patients with Diabetes in Korea: The Fifth Korea National Health and Nutrition Examination Survey
  Ja Young Jeon, Dae Jung Kim, Seung-Hyun Ko, Hyuk-Sang Kwon, Soo Lim, Sung Hee Choi, Chul Sik Kim, Jee Hyun An, Nan Hee Kim, Jong Chul Won, Jae Hyeon Kim, Bong-Yun Cha, Kee-Ho Song
  Diabetes & Metabolism Journal.2014; 38(3): 197.     CrossRef
• Strong correlation between glycaemic variability and total glucose exposure in type 2 diabetes is limited to subjects with satisfactory glycaemic control
  S. Suh, J.Y. Joung, S.M. Jin, M.Y. Kim, J.C. Bae, H.D. Park, M.S. Lee, M.K. Lee, J.H. Kim
  Diabetes & Metabolism.2014; 40(4): 272.     CrossRef
• Current Status of Diabetic Peripheral Neuropathy in Korea: Report of a Hospital-Based Study of Type 2 Diabetic Patients in Korea by the Diabetic Neuropathy Study Group of the Korean Diabetes Association
  Jong Chul Won, Sang Soo Kim, Kyung Soo Ko, Bong-Yun Cha
  Diabetes & Metabolism Journal.2014; 38(1): 25.     CrossRef
• Impact of Age at First Childbirth on Glucose Tolerance Status in Postmenopausal Women: The 2008–2011 Korean National Health and Nutrition Examination Survey
  Jin Hwa Kim, Yun Jung, Sang Yong Kim, Hak Yeon Bae
  Diabetes Care.2014; 37(3): 671.     CrossRef
• Predicting the Development of Diabetes Using the Product of Triglycerides and Glucose: The Chungju Metabolic Disease Cohort (CMC) Study
  Seung-Hwan Lee, Hyuk-Sang Kwon, Yong-Moon Park, Hee-Sung Ha, Seung Hee Jeong, Hae Kyung Yang, Jin-Hee Lee, Hyeon-Woo Yim, Moo-Il Kang, Won-Chul Lee, Ho-Young Son, Kun-Ho Yoon, Maria Eugenia Saez
  PLoS ONE.2014; 9(2): e90430.     CrossRef
• Relationship between socioeconomic status and type 2 diabetes: results from Korea National Health and Nutrition Examination Survey (KNHANES) 2010-2012
  J. Hwang, C. Shon
  BMJ Open.2014; 4(8): e005710.     CrossRef
• Diabetes Mellitus and Osteoporosis
  Kyoung Min Kim
  The Journal of Korean Diabetes.2013; 14(4): 186.     CrossRef
• Study on the Correlation between the Nutrient Intakes and Clinical Indices of Type 2 Diabetes Patients
  Ji-Young Kwon, Hae-Yun Chung
  The Korean Journal of Food And Nutrition.2013; 26(4): 909.     CrossRef
• Role of Sarcopenia in Diabetes Mellitus
  Sang Youl Rhee
  The Journal of Korean Diabetes.2013; 14(4): 178.     CrossRef

As with the dramatic increases in childhood obesity over the past decades, the incidence of type 2 diabetes has increased among children and adolescents in the United States. Insulin resistance is a common feature of childhood obesity and increases the risk of type 2 diabetes, metabolic syndrome, and atherogenic lipoprotein profile in obese youth. Although cross-sectional studies report beneficial effects of physical activity or cardiorespiratory fitness on insulin sensitivity, the role of regular exercise alone (e.g., no calorie restriction) as a strategy to reduce the risk of type 2 diabetes is unclear in obese children and adolescents. In this mini review, we examined the independent effects of various exercise on glucose tolerance and insulin sensitivity in obese youth.

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• Lifestyle and Pharmacological Interventions and Treatment Indications for the Management of Obesity in Children and Adolescents
  Despina Herouvi, George Paltoglou, Alexandra Soldatou, Christina Kalpia, Spyridon Karanasios, Kyriaki Karavanaki
  Children.2023; 10(7): 1230.     CrossRef
• Obesity blunts insulin sensitivity improvements and attenuates strength gains following resistance training in nondiabetic men
  Ramzi A. Al-Horani, Khaled M. Alsays, Osama Abo Alrob
  European Journal of Applied Physiology.2023;[Epub]     CrossRef
• Predictors of postprandial glycaemia, insulinaemia and insulin resistance in adolescents
  Ryan A. Williams, Karah J. Dring, Simon B. Cooper, John G. Morris, Caroline Sunderland, Mary E. Nevill
  British Journal of Nutrition.2021; 125(10): 1101.     CrossRef
• New insights into the pharmacological treatment of pediatric patients with type 2 diabetes
  Tatsuhiko Urakami
  Clinical Pediatric Endocrinology.2018; 27(1): 1.     CrossRef
• Effect of 7 days of exercise on exogenous carbohydrate oxidation and insulin resistance in children with obesity
  Lisa Chu, Katherine M. Morrison, Michael C. Riddell, Sandeep Raha, Brian W. Timmons
  Applied Physiology, Nutrition, and Metabolism.2018; 43(7): 677.     CrossRef
• 12-Week aerobic exercise and nutritional program minimized the presence of the 64Arg allele on insulin resistance
  Gerusa E. Milano-Gai, Lupe Furtado-Alle, Jorge Mota, Leilane Lazarotto, Gisele E. Milano, Ricardo R. de Souza Lehtonen, Ana C.K. Titski, Íncare C. Jesus, Luciane V. Tureck, Rosana B. Radominski, Manuel João Coelho-e-Silva, Neiva Leite
  Journal of Pediatric Endocrinology and Metabolism.2018; 31(9): 1033.     CrossRef
• ADRB2 Gln27Glu polymorphism influenced changes in leptin but not body composition or metabolic and other inflammatory parameters after twelve weeks of combined training in overweight adolescents
  Neiva Leite, Larissa Rosa da Silva, Íncare Correa de Jesus, Wendell Arthur Lopes, Claudia Regina Cavaglieri, Cássio Leandro Consentino, Rosana Bento Radominski, Ricardo Lehtonen Rodrigues de Souza, Luciane Viater Tureck, Lupe Furtado-Alle
  Motriz: Revista de Educação Física.2018;[Epub]     CrossRef
• Patterns of Physical Activity Adherence by Adolescents With Diabetes or Obesity Enrolled in a Personalized Community-Based Intervention
  Sara F. Michaliszyn, Melinda Higgins, Melissa Spezia Faulkner
  The Diabetes Educator.2018; 44(6): 519.     CrossRef
• Diet Quality and Mortality Risk in Metabolically Obese Normal-Weight Adults
  Yong-Moon Mark Park, Teresa T. Fung, Susan E. Steck, Jiajia Zhang, Linda J. Hazlett, Kyungdo Han, Seung-Hwan Lee, Anwar T. Merchant
  Mayo Clinic Proceedings.2016; 91(10): 1372.     CrossRef
• Mediterranean diet and mortality risk in metabolically healthy obese and metabolically unhealthy obese phenotypes
  Y-M Park, S E Steck, T T Fung, J Zhang, L J Hazlett, K Han, A T Merchant
  International Journal of Obesity.2016; 40(10): 1541.     CrossRef
• Efeitos metabólicos do exercício físico na obesidade infantil: uma visão atual
  Santiago Tavares Paes, João Carlos Bouzas Marins, Ana Eliza Andreazzi
  Revista Paulista de Pediatria.2015; 33(1): 122.     CrossRef
• Metabolic effects of exercise on childhood obesity: a current view
  Santiago Tavares Paes, João Carlos Bouzas Marins, Ana Eliza Andreazzi
  Revista Paulista de Pediatria (English Edition).2015; 33(1): 122.     CrossRef
• Impact of regular physical activity on blood glucose control and cardiovascular risk factors in adolescents with type 2 diabetes mellitus - a multicenter study of 578 patients from 225 centres
  A Herbst, T Kapellen, E Schober, C Graf, T Meissner, RW Holl
  Pediatric Diabetes.2015; 16(3): 204.     CrossRef
• Impact of exercise training without caloric restriction on inflammation, insulin resistance and visceral fat mass in obese adolescents
  M. Mendelson, A.‐S. Michallet, D. Monneret, C. Perrin, F. Estève, P. R. Lombard, P. Faure, P. Lévy, A. Favre‐Juvin, J.‐L. Pépin, B. Wuyam, P. Flore
  Pediatric Obesity.2015; 10(4): 311.     CrossRef
• Early-life sleep deprivation persistently depresses melatonin production and bio-energetics of the pineal gland: potential implications for the development of metabolic deficiency
  Li-You Chen, Cheng Tiong, Chung-Hung Tsai, Wen-Chieh Liao, Shun-Fa Yang, Su-Chung Youn, Fu-Der Mai, Hung-Ming Chang
  Brain Structure and Function.2015; 220(2): 663.     CrossRef
• Whey Protein Improves Exercise Performance and Biochemical Profiles in Trained Mice
  WEN-CHYUAN CHEN, WEN-CHING HUANG, CHIEN-CHAO CHIU, YU-KAI CHANG, CHI-CHANG HUANG
  Medicine & Science in Sports & Exercise.2014; 46(8): 1517.     CrossRef
• Type 2 diabetes in the child and adolescent
  Phil Zeitler, Junfen Fu, Nikhil Tandon, Kristen Nadeau, Tatsuhiko Urakami, Timothy Barrett, David Maahs
  Pediatric Diabetes.2014; 15(S20): 26.     CrossRef
• ENDOCRINOLOGY AND ADOLESCENCE: Aerobic exercise reduces insulin resistance markers in obese youth: a meta-analysis of randomized controlled trials
  Antonio García-Hermoso, Jose M Saavedra, Yolanda Escalante, Mairena Sánchez-López, Vicente Martínez-Vizcaíno
  European Journal of Endocrinology.2014; 171(4): R163.     CrossRef

Vision loss in diabetic retinopathy (DR) is attributable to retinal vascular disorders that result in macular edema and neoangiogenesis. In addition to laser photocoagulation therapy, intraocular injections of antivascular endothelial growth factor drugs have contributed to the treatment of these disease conditions. Nonetheless, the clinical feasibility of intraocular drug administration has raised an increasing demand to develop alternative drugs that can fundamentally ameliorate the retinal vascular dysfunctions in DR. For this purpose, experimental animal models that reproduce human DR would be of clinical benefit. Despite the unavailability of DR models in rats or mice, pharmacological and genetic manipulations without hyperglycemia have successfully recapitulated retinal edema and neoangiogenesis in postnatal mouse retinas, thereby enabling the understanding of the pathophysiology underlying DR. This article highlights the utility of experimental mouse models of retinal vascular abnormalities and discusses cellular and molecular mechanisms responsible for the onset and progression of DR. These approaches will lead to the identification of novel drug targets for the restoration of vascular integrity and regeneration of functional capillaries in DR.

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• A Protective Role for RHOJ in NonSmall Cell Lung Cancer Based on Integrated Bioinformatics Analysis
  Tian Zeng, Can Chen, Pan Yang, Wenwei Zuo, Xiaoqing Liu, Yanling Zhang
  Journal of Computational Biology.2020; 27(7): 1092.     CrossRef

Obesity is a state of chronic low-grade systemic inflammation. This chronic inflammation is deeply involved in insulin resistance, which is the underlying condition of type 2 diabetes and metabolic syndrome. A significant advance in our understanding of obesity-associated inflammation and insulin resistance has been recognition of the critical role of adipose tissue macrophages (ATMs). Chemokines are small proteins that direct the trafficking of immune cells to sites of inflammation. In addition, chemokines activate the production and secretion of inflammatory cytokines through specific G protein-coupled receptors. ATM accumulation through C-C motif chemokine receptor 2 and its ligand monocyte chemoattractant protein-1 is considered pivotal in the development of insulin resistance. However, chemokine systems appear to exhibit a high degree of functional redundancy. Currently, more than 50 chemokines and 18 chemokine receptors exhibiting various physiological and pathological properties have been discovered. Therefore, additional, unidentified chemokine/chemokine receptor pathways that may play significant roles in ATM recruitment and insulin sensitivity remain to be fully identified. This review focuses on some of the latest findings on chemokine systems linking obesity to inflammation and subsequent development of insulin resistance.

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• Apolipoprotein A-IV reduced metabolic inflammation in white adipose tissue by inhibiting IKK and JNK signaling in adipocytes
  Xiao-Huan Liu, Yupeng Zhang, Liao Chang, Yang Wei, Na Huang, Jin-Ting Zhou, Cheng Cheng, Jianbo Zhang, Jing Xu, Zongfang Li, Xiaoming Li
  Molecular and Cellular Endocrinology.2023; 559: 111813.     CrossRef
• Neutralizing MIP3αReduces Renal Immune Cell Infiltration and Progressive Renal Injury in Young Obese Dahl Salt-Sensitive Rats
  Ubong S. Ekperikpe, Bibek Poudel, Corbin A. Shields, Sautan Mandal, Denise C. Cornelius, Jan M. Williams
  Journal of Pharmacology and Experimental Therapeutics.2023; 384(3): 445.     CrossRef
• Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats
  Ubong S. Ekperikpe, Sautan Mandal, Stephen J. Holt, Jacori K. Daniels, Tyler D. Johnson, Jonita S. Cooper, Sarah M. Safir, Denise C. Cornelius, Jan M. Williams
  American Journal of Physiology-Renal Physiology.2023; 325(3): F363.     CrossRef
• Hepatic T-cell senescence and exhaustion are implicated in the progression of fatty liver disease in patients with type 2 diabetes and mouse model with nonalcoholic steatohepatitis
  Byeong Chang Sim, Yea Eun Kang, Sun Kyoung You, Seong Eun Lee, Ha Thi Nga, Ho Yeop Lee, Thi Linh Nguyen, Ji Sun Moon, Jingwen Tian, Hyo Ju Jang, Jeong Eun Lee, Hyon-Seung Yi
  Cell Death & Disease.2023;[Epub]     CrossRef
• Inflammatory Status of Monocytes in Type 2 Diabetes Mellitus
  T. V. Kirichenko, L. A. Bochkareva, L. V. Nedosugova, Yu. V. Markina, I. A. Kuzina, N. A. Petunina, T. V. Tolstik, A. I. Bogatyreva, V. A. Antonov, A. M. Markin
  Journal Biomed.2023; 19(4): 25.     CrossRef
• Non-alcoholic fatty liver disease: a multi-system disease influenced by ageing and sex, and affected by adipose tissue and intestinal function
  Josh Bilson, Jaswinder K. Sethi, Christopher D. Byrne
  Proceedings of the Nutrition Society.2022; 81(2): 146.     CrossRef
• Puerarin Attenuates Obesity-Induced Inflammation and Dyslipidemia by Regulating Macrophages and TNF-Alpha in Obese Mice
  Ji-Won Noh, Hee-Kwon Yang, Min-Soo Jun, Byung-Cheol Lee
  Biomedicines.2022; 10(1): 175.     CrossRef
• Beneficial effects of fermented barley extracts on inflammatory status and gut microbiota in high-fat diet-induced obese rats
  Xiaozhong Huang, Qingguo Cao, Cen Chen, Zhenglin Xie, Jinshan Fan
  Journal of Applied Microbiology.2022; 133(6): 3708.     CrossRef
• Periodontitis induced by Porphyromonas gingivalis drives impaired glucose metabolism in mice
  Ni Kang, Yong Zhang, Fei Xue, Jinyu Duan, Fan Chen, Yu Cai, Qingxian Luan
  Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
• Granulocytic MDSC with Deficient CCR5 Alleviates Lipogenesis and Inflammation in Nonalcoholic Fatty Liver Disease
  Tzu-Chieh Liao, Jiung-Pang Huang, Yu-Ting Tsai, Wei-Ching Shih, Chi-Chang Juan, Po-Shiuan Hsieh, Li-Man Hung, Chao-Lan Yu
  International Journal of Molecular Sciences.2022; 23(21): 13048.     CrossRef
• Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population
  Shaza B. Zaghlool, Anna Halama, Nisha Stephan, Valborg Gudmundsdottir, Vilmundur Gudnason, Lori L. Jennings, Manonanthini Thangam, Emma Ahlqvist, Rayaz A. Malik, Omar M. E. Albagha, Abdul Badi Abou‑Samra, Karsten Suhre
  Nature Communications.2022;[Epub]     CrossRef
• CX3CL1-CX3CR1 Signaling Deficiency Exacerbates Obesity-induced Inflammation and Insulin Resistance in Male Mice
  Mayumi Nagashimada, Kazuki Sawamoto, Yinhua Ni, Hironori Kitade, Naoto Nagata, Liang Xu, Masuko Kobori, Naofumi Mukaida, Tatsuya Yamashita, Shuichi Kaneko, Tsuguhito Ota
  Endocrinology.2021;[Epub]     CrossRef
• Di(2-ethylhexyl)phthalate exposure exacerbates metabolic disorders in diet-induced obese mice
  Jhih-Wei Hsu, Chung-Yi Nien, Hsin-Wei Chen, Feng-Yuan Tsai, Szu-Ching Yeh, Yung-Hsi Kao, Tsui-Chun Tsou
  Food and Chemical Toxicology.2021; 156: 112439.     CrossRef
• The Chemokine Systems at the Crossroads of Inflammation and Energy Metabolism in the Development of Obesity
  Pei-Chi Chan, Po-Shiuan Hsieh
  International Journal of Molecular Sciences.2021; 22(24): 13528.     CrossRef
• β-Neoendorphin Enhances Wound Healing by Promoting Cell Migration in Keratinocyte
  Dong Joo Yang, Sang Hyun Moh, Yun-Hee Choi, Ki Woo Kim
  Molecules.2020; 25(20): 4640.     CrossRef
• Transcriptome Analysis of Testis from HFD-Induced Obese Rats (Rattus norvigicus) Indicated Predisposition for Male Infertility
  Ahmed M. El-Shehawi, Samir El-Shazly, Mohamed Ahmed, Mohamed Alkafafy, Samy Sayed, Samy Farouk, Saqer S. Alotaibi, Mona M. Elseehy
  International Journal of Molecular Sciences.2020; 21(18): 6493.     CrossRef
• Anti-Obesity Effects of Petasites japonicus (Meowi) Ethanol Extract on RAW 264.7 Macrophages and 3T3-L1 Adipocytes and Its Characterization of Polyphenolic Compounds
  Eun Mi Ahn, Gelila Asamenew, Heon Woong Kim, Sang Hoon Lee, Seon-Mi Yoo, Soo-Muk Cho, Youn-Soo Cha, Min-Sook Kang
  Nutrients.2020; 12(5): 1261.     CrossRef
• Polymorphisms in miRNA binding sites involved in metabolic diseases in mice and humans
  Pascal Gottmann, Meriem Ouni, Lisa Zellner, Markus Jähnert, Kilian Rittig, Dirk Walther, Annette Schürmann
  Scientific Reports.2020;[Epub]     CrossRef
• Asthma and metabolic syndrome: a comprehensive systematic review and meta-analysis of observational studies
  Nahid Karamzad, Neda Izadi, Sarvin Sanaie, Elham Ahmadian, Aziz Eftekhari, Mark J.M. Sullman, Saeid Safiri
  Journal of Cardiovascular and Thoracic Research.2020; 12(2): 120.     CrossRef
• Elevated adipose tissue associated IL-2 expression in obesity correlates with metabolic inflammation and insulin resistance
  Shihab Kochumon, Ashraf Al Madhoun, Fatema Al-Rashed, Reeby Thomas, Sardar Sindhu, Ebaa Al-Ozairi, Fahd Al-Mulla, Rasheed Ahmad
  Scientific Reports.2020;[Epub]     CrossRef
• Obesity-related hypoxia via miR-128 decreases insulin-receptor expression in human and mouse adipose tissue promoting systemic insulin resistance
  Biagio Arcidiacono, Eusebio Chiefari, Anna Foryst-Ludwig, Giuseppe Currò, Giuseppe Navarra, Francesco S. Brunetti, Maria Mirabelli, Domenica M. Corigliano, Ulrich Kintscher, Domenico Britti, Vincenzo Mollace, Daniela P. Foti, Ira D. Goldfine, Antonio Brun
  eBioMedicine.2020; 59: 102912.     CrossRef
• Chemokines and their association with body mass index among healthy Saudis
  Steve Harakeh, Gauthaman Kalamegam, Peter N. Pushparaj, Ahmed Al-Hejin, Sulaiman M. Alfadul, Turki Al Amri, Salah Barnawi, Hadeel Al Sadoun, Ahmed A. Mirza, Esam Azhar
  Saudi Journal of Biological Sciences.2020; 27(1): 6.     CrossRef
• New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions
  Bei Guo, Tongtian Zhuang, Feng Xu, Xiao Lin, Fuxingzi Li, Su-Kang Shan, Feng Wu, Jia-Yu Zhong, Yi Wang, Ming-Hui Zheng, Qiu-Shuang Xu, Ullah Muhammad Hasnain Ehsan, Ling-Qing Yuan
  Frontiers in Physiology.2020;[Epub]     CrossRef
• Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic β-Cells to Type 2 Diabetes
  Petr Ježek, Martin Jabůrek, Lydie Plecitá-Hlavatá
  Antioxidants & Redox Signaling.2019; 31(10): 722.     CrossRef
• Interleukin-22 Induces the Infiltration of Visceral Fat Tissue by a Discrete Subset of Duffy Antigen Receptor for Chemokine-Positive M2-Like Macrophages in Response to a High Fat Diet
  Eun-Young Kim, Hye Mi Noh, Bongkun Choi, Ji-Eun Park, Ji-Eun Kim, Youngsaeng Jang, Hyung Keun Lee, Eun-Ju Chang
  Cells.2019; 8(12): 1587.     CrossRef
• The chemokine system and its role in obesity
  Wenhua Xue, Zhirui Fan, Lifeng Li, Jingli Lu, Yunkai Zhai, Jie Zhao
  Journal of Cellular Physiology.2019; 234(4): 3336.     CrossRef
• Inonotus sanghuang Polyphenols Attenuate Inflammatory Response Via Modulating the Crosstalk Between Macrophages and Adipocytes
  Mengdi Zhang, Yu Xie, Xing Su, Kun Liu, Yijie Zhang, Wuyan Pang, Junpeng Wang
  Frontiers in Immunology.2019;[Epub]     CrossRef
• Therapeutic Effects of Adipose Stem Cells from Diabetic Mice for the Treatment of Type 2 Diabetes
  Mengmeng Wang, Lili Song, Charlie Strange, Xiao Dong, Hongjun Wang
  Molecular Therapy.2018; 26(8): 1921.     CrossRef
• Inflammatory Cytokine Profiles in Visceral and Subcutaneous Adipose Tissues of Obese Patients Undergoing Bariatric Surgery Reveal Lack of Correlation With Obesity or Diabetes
  Volatiana Rakotoarivelo, Gregory Lacraz, Marian Mayhue, Christine Brown, Diane Rottembourg, Julie Fradette, Subburaj Ilangumaran, Alfredo Menendez, Marie-France Langlois, Sheela Ramanathan
  eBioMedicine.2018; 30: 237.     CrossRef
• Resveratrol reduces the inflammatory response in adipose tissue and improves adipose insulin signaling in high-fat diet-fed mice
  Shibin Ding, Jinjin Jiang, Zhe Wang, Guofu Zhang, Jianli Yin, Xiaoya Wang, Sui Wang, Zengli Yu
  PeerJ.2018; 6: e5173.     CrossRef
• Dual CCR2/5 Antagonist Attenuates Obesity‐Induced Insulin Resistance by Regulating Macrophage Recruitment and M1/M2 Status
  Ji Hye Huh, Hong Min Kim, Eun Soo Lee, Mi Hye Kwon, Bo Ra Lee, Hyun‐Jeong Ko, Choon Hee Chung
  Obesity.2018; 26(2): 378.     CrossRef
• Rosiglitazone Elicits an Adiponectin-Mediated Insulin-Sensitizing Action at the Adipose Tissue-Liver Axis in Otsuka Long-Evans Tokushima Fatty Rats
  Jia Li, Yao-Ming Xue, Bo Zhu, Yong-Hua Pan, Yan Zhang, Chunxia Wang, Yuhao Li
  Journal of Diabetes Research.2018; 2018: 1.     CrossRef
• Myeloid-specific deletion of thrombospondin 1 protects against inflammation and insulin resistance in long-term diet-induced obese male mice
  Hasiyet Memetimin, Dong Li, Kaiyuan Tan, Changcheng Zhou, Ying Liang, Yadi Wu, Shuxia Wang
  American Journal of Physiology-Endocrinology and Metabolism.2018; 315(6): E1194.     CrossRef
• From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions
  Tiziana Caputo, Federica Gilardi, Béatrice Desvergne
  FEBS Letters.2017; 591(19): 3061.     CrossRef
• Effects of Karela (Bitter Melon; Momordica charantia) on genes of lipids and carbohydrates metabolism in experimental hypercholesterolemia: biochemical, molecular and histopathological study
  Dalia Yossri Saad, Mohamed Mohamed Soliman, Ahmed A. Baiomy, Magdy Hassan Yassin, Hanan Basiouni El-Sawy
  BMC Complementary and Alternative Medicine.2017;[Epub]     CrossRef
• Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet–induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles
  Chun-Chung Wang, Jui-Hung Yen, Yi-Cheng Cheng, Chia-Yu Lin, Cheng-Ta Hsieh, Rung-Jiun Gau, Shu-Jiau Chiou, Hwan-You Chang
  Food & Nutrition Research.2017; 61(1): 1379861.     CrossRef
• Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB
  Leen Catrysse, Geert van Loo
  Trends in Cell Biology.2017; 27(6): 417.     CrossRef
• RETRACTED ARTICLE: TREM-1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population
  Saravanan Subramanian, Pradeep K. Pallati, Poonam Sharma, Devendra K. Agrawal, Kalyana C. Nandipati
  Journal of Translational Medicine.2017;[Epub]     CrossRef
• The Role of Heparin Cofactor Ⅱ in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice
  Kiyoe Kurahashi, Seika Inoue, Sumiko Yoshida, Yasumasa Ikeda, Kana Morimoto, Ryoko Uemoto, Kazue Ishikawa, Takeshi Kondo, Tomoyuki Yuasa, Itsuro Endo, Masato Miyake, Seiichi Oyadomari, Toshio Matsumoto, Masahiro Abe, Hiroshi Sakaue, Ken-ichi Aihara
  Journal of Atherosclerosis and Thrombosis.2017; 24(12): 1215.     CrossRef
• Pure total flavonoids from citrus improve non-alcoholic fatty liver disease by regulating TLR/CCL signaling pathway: A preliminary high-throughput ‘omics’ study
  Liyan Wu, Maoxiang Yan, Jianping Jiang, Beihui He, Wei Hong, Zhiyun Chen
  Biomedicine & Pharmacotherapy.2017; 93: 316.     CrossRef
• The association between metabolic health, obesity phenotype and the risk of breast cancer
  Yong‐Moon Mark Park, Alexandra J. White, Hazel B. Nichols, Katie M. O'Brien, Clarice R. Weinberg, Dale P. Sandler
  International Journal of Cancer.2017; 140(12): 2657.     CrossRef
• Immune regulation of glucose and lipid metabolism
  Tsuguhito Ota
  Diabetology International.2017; 8(3): 257.     CrossRef
• Distinguishing features of body mass index and psoriasis in men and women in Japan: A hospital‐based case–control study
  Reiko Naito, Shinichi Imafuku
  The Journal of Dermatology.2016; 43(12): 1406.     CrossRef
• Change in Serum Bilirubin Level as a Predictor of Incident Metabolic Syndrome
  You-Bin Lee, Seung-Eun Lee, Ji Eun Jun, Jae Hwan Jee, Ji Cheol Bae, Sang-Man Jin, Jae Hyeon Kim, Sheng-Nan Lu
  PLOS ONE.2016; 11(12): e0168253.     CrossRef
• Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked?
  Kanwal Rehman, Muhammad Sajid Hamid Akash
  Journal of Biomedical Science.2016;[Epub]     CrossRef
• Chemokine genetic polymorphism in human health and disease
  Tabish Qidwai
  Immunology Letters.2016; 176: 128.     CrossRef
• The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction
  Che-Pei Kung, Julia I-Ju Leu, Subhasree Basu, Sakina Khaku, Frederick Anokye-Danso, Qin Liu, Donna L. George, Rexford S. Ahima, Maureen E. Murphy
  Cell Reports.2016; 14(10): 2413.     CrossRef
• E3 ubiquitin ligases as novel targets for inflammatory diseases
  Santosh Kumar Goru, Anuradha Pandey, Anil Bhanudas Gaikwad
  Pharmacological Research.2016; 106: 1.     CrossRef
• Immune and Inflammatory Signaling Pathways in Exercise and Obesity
  Karsten Krüger, Frank C. Mooren, Klaus Eder, Robert Ringseis
  American Journal of Lifestyle Medicine.2016; 10(4): 268.     CrossRef
• CCL2 level is elevated with metabolic syndrome and CXCL10 level is correlated with visceral fat area in obese children
  Masahiro Ishii, Shunsuke Araki, Motohide Goto, Yukiyo Yamamoto, Koichi Kusuhara
  Endocrine Journal.2016; 63(9): 795.     CrossRef
• CCL2 gene polymorphism is associated with post-transplant diabetes mellitus
  Ewa Dabrowska-Zamojcin, Maciej Romanowski, Violetta Dziedziejko, Agnieszka Maciejewska-Karlowska, Marek Sawczuk, Krzysztof Safranow, Leszek Domanski, Andrzej Pawlik
  International Immunopharmacology.2016; 32: 62.     CrossRef
• Blocking CXCR7-mediated adipose tissue macrophages chemotaxis attenuates insulin resistance and inflammation in obesity
  Hongxia Peng, Hu Zhang, Honglei Zhu
  Biochemical and Biophysical Research Communications.2016; 479(4): 649.     CrossRef
• A brief glimpse at CTRP3 and CTRP9 in lipid metabolism and cardiovascular protection
  Yang Yang, Yue Li, Zhiqiang Ma, Shuai Jiang, Chongxi Fan, Wei Hu, Dongjin Wang, Shouyin Di, Yang Sun, Wei Yi
  Progress in Lipid Research.2016; 64: 170.     CrossRef
• Obesity-associated cancer: an immunological perspective
  Melissa J. Conroy, Margaret R. Dunne, Claire L. Donohoe, John V. Reynolds
  Proceedings of the Nutrition Society.2016; 75(2): 125.     CrossRef
• The Dietary Isoflavone Daidzein Reduces Expression of Pro-Inflammatory Genes through PPARα/γ and JNK Pathways in Adipocyte and Macrophage Co-Cultures
  Yuri Sakamoto, Junko Kanatsu, Mariko Toh, Ayano Naka, Kazuo Kondo, Kaoruko Iida, Makoto Makishima
  PLOS ONE.2016; 11(2): e0149676.     CrossRef
• Response of gut microbiota and inflammatory status to bitter melon (Momordica charantia L.) in high fat diet induced obese rats
  Juan Bai, Ying Zhu, Ying Dong
  Journal of Ethnopharmacology.2016; 194: 717.     CrossRef
• SIRT1 and insulin resistance
  Yue Cao, Xinli Jiang, Huijie Ma, Yuling Wang, Peng Xue, Yan Liu
  Journal of Diabetes and its Complications.2016; 30(1): 178.     CrossRef
• CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance
  Milton-Omar Guzmán-Ornelas, Marcelo Heron Petri, Mónica Vázquez-Del Mercado, Efraín Chavarría-Ávila, Fernanda-Isadora Corona-Meraz, Sandra-Luz Ruíz-Quezada, Perla-Monserrat Madrigal-Ruíz, Jorge Castro-Albarrán, Flavio Sandoval-García, Rosa-Elena Navarro-H
  Journal of Diabetes Research.2016; 2016: 1.     CrossRef
• Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice
  Jongkil Kim, Kunho Chung, Changseon Choi, Jagadish Beloor, Irfan Ullah, Nahyeon Kim, Kuen Yong Lee, Sang-Kyung Lee, Priti Kumar
  Molecular Therapy - Nucleic Acids.2016; 5: e280.     CrossRef
• Les adipokines : état des lieux et nouveautés
  J.-P. Bastard, C. Bastard, S. Fellahi, C. Vatier, J. Capeau, B. Fève
  Obésité.2016; 11(3): 181.     CrossRef
• TM-25659-Induced Activation of FGF21 Level Decreases Insulin Resistance and Inflammation in Skeletal Muscle via GCN2 Pathways
  Jong Gab Jung, Sang-A Yi, Sung-E Choi, Yup Kang, Tae Ho Kim, Ja Young Jeon, Myung Ae Bae, Jin Hee Ahn, Hana Jeong, Eun Sook Hwang, Kwan-Woo Lee
  Molecules and Cells.2015; 38(12): 1037.     CrossRef
• Aromatase Controls Sjögren Syndrome–Like Lesions through Monocyte Chemotactic Protein-1 in Target Organ and Adipose Tissue–Associated Macrophages
  Akihiko Iwasa, Rieko Arakaki, Naoko Honma, Aya Ushio, Akiko Yamada, Tomoyuki Kondo, Emi Kurosawa, Satoko Kujiraoka, Takaaki Tsunematsu, Yasusei Kudo, Eiji Tanaka, Noriko Yoshimura, Nobuhiro Harada, Yoshio Hayashi, Naozumi Ishimaru
  The American Journal of Pathology.2015; 185(1): 151.     CrossRef
• Macrophage Migration Inhibitory Factor Promoter Polymorphisms (−794 CATT5–8and −173 G>C): Relationship with mRNA Expression and Soluble MIF Levels in Young Obese Subjects
  Inés Matia-García, Lorenzo Salgado-Goytia, José F. Muñoz-Valle, Samuel García-Arellano, Jorge Hernández-Bello, Aralia B. Salgado-Bernabé, Isela Parra-Rojas
  Disease Markers.2015; 2015: 1.     CrossRef
• Niche-Dependent Regulations of Metabolic Balance in High-Fat Diet–Induced Diabetic Mice by Mesenchymal Stromal Cells
  Andrea Tung-Qian Ji, Yun-Chuang Chang, Yun-Ju Fu, Oscar K. Lee, Jennifer H. Ho
  Diabetes.2015; 64(3): 926.     CrossRef
• Simvastatin Does Not Reduce Chemokine Production in Obesity Without Comorbidities
  Karla Silva Fernandes, Samantha Ribeiro Béla, Vanessa L. Andrade, Tatiane Figueiredo de Moraes, Olindo de Assis Martins-Filho, Valéria Cristina Sandrim
  Inflammation.2015; 38(3): 1297.     CrossRef
• Asthma and metabolic syndrome: Current knowledge and future perspectives
  Laura Serafino-Agrusa
  World Journal of Clinical Cases.2015; 3(3): 285.     CrossRef
• Analysis of the correlation between serum resistin and the variability of erythropoietin responsiveness in patients with chronic kidney disease
  HONGHAO ZHANG, XIUJIANG LI, YANHONG KAN, FAN YANG, YUE HOU, YUJUN DU
  Experimental and Therapeutic Medicine.2015; 10(5): 1925.     CrossRef
• Preventive effects of bitter melon (Momordica charantia) against insulin resistance and diabetes are associated with the inhibition of NF-κB and JNK pathways in high-fat-fed OLETF rats
  Soo Jin Yang, Jung Mook Choi, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Cheol-Young Park
  The Journal of Nutritional Biochemistry.2015; 26(3): 234.     CrossRef
• Association of serum angiopoietin-like protein 2 with carotid intima-media thickness in subjects with type 2 diabetes
  Chang Hee Jung, Woo Je Lee, Min Jung Lee, Yu Mi Kang, Jung Eun Jang, Jaechan Leem, Yoo La Lee, So Mi Seol, Hae Kyeong Yoon, Joong-Yeol Park
  Cardiovascular Diabetology.2015;[Epub]     CrossRef
• Effects of intermittent exercise on biomarkers of cardiovascular risk in night shift workers
  Seung-Taek Lim, Seok-Ki Min, Yoo-Chan Kwon, Sang-Kab Park, Hyuntae Park
  Atherosclerosis.2015; 242(1): 186.     CrossRef
• Milk-derived peptide Val-Pro-Pro (VPP) inhibits obesity-induced adipose inflammation via an angiotensin-converting enzyme (ACE) dependent cascade
  Yoko Sawada, Yuri Sakamoto, Mariko Toh, Nozomi Ohara, Yuiko Hatanaka, Ayano Naka, Yoshimi Kishimoto, Kazuo Kondo, Kaoruko Iida
  Molecular Nutrition & Food Research.2015; 59(12): 2502.     CrossRef
• Ubiquitin ligase Cbl-b and obesity-induced insulin resistance [Review]
  Tomoki Abe, Katsuya Hirasaka, Shohei Kohno, Arisa Ochi, Naoko Yamagishi, Ayako Ohno, Shigetada Teshima-Kondo, Takeshi Nikawa
  Endocrine Journal.2014; 61(6): 529.     CrossRef
• Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet‐induced obesity
  Longbiao Yao, Janet Heuser‐Baker, Oana Herlea‐Pana, Nan Zhang, Luke I. Szweda, Timothy M. Griffin, Jana Barlic‐Dicen
  The FASEB Journal.2014; 28(10): 4534.     CrossRef
• Unprotected daily sun exposure is differently associated with central adiposity and beta-cell dysfunction by gender: The Korean national health and nutrition examination survey (KNHANES) V
  Jung Hun Ohn, In Ho Kwon, Juri Park, Ohk Hyun Ryu, Seong Jin Lee, Doo-Man Kim, Sung-Hee Ihm, Moon-Gi Choi, Hyung Joon Yoo, Eun-Gyoung Hong
  Environmental Research.2014; 133: 253.     CrossRef
• Anti-adipogenic effect of mulberry leaf ethanol extract in 3T3-L1 adipocytes
  Soo Jin Yang, Na-Young Park, Yunsook Lim
  Nutrition Research and Practice.2014; 8(6): 613.     CrossRef
• What We Talk About When We Talk About Fat
  Evan D. Rosen, Bruce M. Spiegelman
  Cell.2014; 156(1-2): 20.     CrossRef
• Effect of diabetes on the relation between troponin T and inflammatory markers in patients on hemodialysis
  Emília Mácsai, Ilona Németh, Attila Benke, Gyula Dávid
  Orvosi Hetilap.2014; 155(16): 627.     CrossRef
• Active ingredients from natural botanicals in the treatment of obesity
  W.‐L. Zhang, L. Zhu, J.‐G. Jiang
  Obesity Reviews.2014; 15(12): 957.     CrossRef
• Hypertrophic Obesity and Subcutaneous Adipose Tissue Dysfunction
  Anna Meiliana, Andi Wijaya
  The Indonesian Biomedical Journal.2014; 6(2): 79.     CrossRef
• Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus
  Nailú Angélica Sinicato, Mariana Postal, Fernando Augusto Peres, Karina de Oliveira Peliçari, Roberto Marini, Allan de Oliveira dos Santos, Celso Dario Ramos, Simone Appenzeller
  Journal of Immunology Research.2014; 2014: 1.     CrossRef
• Assessment of the number and function of macrophages in the placenta of gestational diabetes mellitus patients
  Jun Yu, Yong Zhou, Juan Gui, Ai-zhen Li, Xiao-ling Su, Ling Feng
  Journal of Huazhong University of Science and Technology [Medical Sciences].2013; 33(5): 725.     CrossRef

Adenosine triphosphate (ATP)-sensitive potassium (K_ATP) channels in pancreatic β-cells play a crucial role in insulin secretion and glucose homeostasis. These channels are composed of two subunits: a pore-forming subunit (Kir6.2) and a regulatory subunit (sulphonylurea receptor-1). Recent studies identified large number of gain of function mutations in the regulatory subunit of the channel which cause neonatal diabetes. Majority of mutations cause neonatal diabetes alone, however some lead to a severe form of neonatal diabetes with associated neurological complications. This review focuses on the functional effects of these mutations as well as the implications for treatment.

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Citations to this article as recorded by  

• Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients With Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes
  Pamela Bowman, Frances Mathews, Fabrizio Barbetti, Maggie H. Shepherd, Janine Sanchez, Barbara Piccini, Jacques Beltrand, Lisa R. Letourneau-Freiberg, Michel Polak, Siri Atma W. Greeley, Eamon Rawlins, Tarig Babiker, Nicholas J. Thomas, Elisa De Franco, S
  Diabetes Care.2021; 44(1): 35.     CrossRef
• Structure based analysis of KATP channel with a DEND syndrome mutation in murine skeletal muscle
  Shoichiro Horita, Tomoyuki Ono, Saul Gonzalez-Resines, Yuko Ono, Megumi Yamachi, Songji Zhao, Carmen Domene, Yuko Maejima, Kenju Shimomura
  Scientific Reports.2021;[Epub]     CrossRef
• Clinical and Genetic Characteristics of ABCC8 Nonneonatal Diabetes Mellitus: A Systematic Review
  Meng Li, Xueyao Han, Linong Ji, Karim Gariani
  Journal of Diabetes Research.2021; 2021: 1.     CrossRef
• Spacial models of malfunctioned protein complexes help to elucidate signal transduction critical for insulin release
  Katarzyna Walczewska-Szewc, Wieslaw Nowak
  Biosystems.2019; 177: 48.     CrossRef
• Cantu syndrome–associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms
  Conor McClenaghan, Alex Hanson, Monica Sala-Rabanal, Helen I. Roessler, Dragana Josifova, Dorothy K. Grange, Gijs van Haaften, Colin G. Nichols
  Journal of Biological Chemistry.2018; 293(6): 2041.     CrossRef
• Hyperinsulinism-Causing Mutations Cause Multiple Molecular Defects in SUR1 NBD1
  Claudia P. Alvarez, Marijana Stagljar, D. Ranjith Muhandiram, Voula Kanelis
  Biochemistry.2017; 56(18): 2400.     CrossRef
• K_ATP Channel Mutations and Neonatal Diabetes
  Kenju Shimomura, Yuko Maejima
  Internal Medicine.2017; 56(18): 2387.     CrossRef
• Molecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotides
  Heidi de Wet, Peter Proks
  Biochemical Society Transactions.2015; 43(5): 901.     CrossRef
• Successful development and use of a thermodynamic stability screen for optimizing the yield of nucleotide binding domains
  Elvin D. de Araujo, Voula Kanelis
  Protein Expression and Purification.2014; 103: 38.     CrossRef
• Reclasificación y transferencia de insulina a sulfonilureas en un paciente con mutación en KCNJ11 tras 15 años de tratamiento con insulina
  Magdalena Capponi, Carmen Quirós, Ignacio Conget, Enric Esmatjes, Marga Giménez
  Avances en Diabetología.2014; 30(4): 115.     CrossRef