Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal


Author index

Page Path
HOME > Browse > Author index
Young Woo Kang  (Kang YW) 1 Article
Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Patients with Type 2 Diabetes Mellitus
Jun Ouk Ha, Tae Hee Lee, Chang Won Lee, Ja Young Park, Seong Ho Choi, Hee Seung Park, Jae Seung Lee, Seung Heon Lee, Eun Hee Seo, Young Hwan Kim, Young Woo Kang
Diabetes Metab J. 2016;40(4):297-307.   Published online June 8, 2016
  • 5,190 View
  • 55 Download
  • 8 Web of Science
  • 9 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   

Gastrointestinal symptoms are common in patients with type 2 diabetes mellitus (T2DM). The prevalence of gastroesophageal reflux disease (GERD) in Korea appears to be increasing. Some studies have shown that T2DM is a risk factor for symptomatic GERD. However, this possibility is still debated, and the pathogenesis of GERD in T2DM is not yet fully understood. The aim of this study was to analyze the prevalence and risk factors (including autonomic neuropathy) of GERD in patients with T2DM.


This cross-sectional case-control study enrolled T2DM patients (n=258) and healthy controls (n=184). All participants underwent physical examinations and laboratory tests. We evaluated medical records and long-term diabetes complications, including peripheral and autonomic neuropathy in patients with T2DM. Esophagogastroduodenoscopy was performed in all patients. The Los Angeles (LA) classification was used to grade GERD. GERD was defined as LA grade A (or higher) or minimal change with GERD symptoms. GERD symptoms were examined using a frequency scale. Data were expressed as mean±standard error. Independent t-tests or chi-square tests were used to make comparisons between groups.


The prevalence of GERD (32.6% vs. 35.9%, P=0.266) and GERD symptoms (58.8% vs. 59.2%, P=0.503) was not significantly different between T2DM patients and controls. We found no significant differences between T2DM patients with GERD and T2DM patients without GERD with respect to diabetic complications, including autonomic neuropathy, peripheral neuropathy, duration of DM, and glucose control.


The prevalence of GERD in patients with T2DM showed no difference from that of controls. GERD was also not associated with peripheral and cardiovascular autonomic neuropathy, age, or duration of DM in patients with T2DM.


Citations to this article as recorded by  
  • Ураження органів травлення при цукровому діабеті
    M.O. Borovets , О.М. Radchenko , Kh.A. Moskva , O.Yo. Komarytsya , A.M. Urbanovych
    Endokrynologia.2023; 28(3): 270.     CrossRef
  • Metabolic effects of bariatric surgery on patients with type 2 diabetes: a population-based study
    Erman O. Akpinar, Ronald S.L. Liem, Simon W. Nienhuijs, Jan Willem M. Greve, Perla J. Marang-van de Mheen, L.M. de Brauw, S.M.M. de Castro, S.L. Damen, A. Demirkiran, M. Dunkelgrun, I.F. Faneyte, G. van ‘t Hof, I.M.C. Janssen, R.A. Klaassen, E.A.G.L. Laga
    Surgery for Obesity and Related Diseases.2021; 17(7): 1349.     CrossRef
  • The effect of proton pump inhibitors on glycaemic control in diabetic patients
    Muhammad Ali Rajput, Fizzah Ali, Tabassum Zehra, Shahid Zafar, Gunesh Kumar
    Journal of Taibah University Medical Sciences.2020; 15(3): 218.     CrossRef
  • Prediabetes and gastrointestinal (GI) symptoms; a cross-sectional study
    Akram Ghadiri-Anari, Somaye Gholami, Fariba Zolfaghari, Nasim Namiranian
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 844.     CrossRef
  • Gastrointestinal Symptoms in Diabetes: Prevalence, Assessment, Pathogenesis, and Management
    Yang T. Du, Christopher K. Rayner, Karen L. Jones, Nicholas J. Talley, Michael Horowitz
    Diabetes Care.2018; 41(3): 627.     CrossRef
  • Features of Endoscopic Changes in Gastroesophageal Reflux Disease in Patients with Type II Diabetes Mellitus
    Ye. S. Sirchak, M. P. Stan, Yo. I. Pichkar, V. V. Vajs
    Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2018; 3(5): 166.     CrossRef
  • Prevalence and Correlates of Gastroesophageal Reflux Disease in Southern Iran: Pars Cohort Study
    Zohre Khodamoradi, Abdullah Gandomkar, Hossein Poustchi, Alireza Salehi, Mohammad Hadi Imanieh, Arash Etemadi, Reza Malekzadeh
    Middle East Journal of Digestive Diseases.2017; 9(3): 129.     CrossRef
  • Letter: Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Patients with Type 2 Diabetes Mellitus (Diabetes Metab J2016;40:297-307)
    Dongwon Yi
    Diabetes & Metabolism Journal.2016; 40(5): 418.     CrossRef
  • Response: Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Patients with Type 2 Diabetes Mellitus (Diabetes Metab J2016;40:297-307)
    Jun Ouk Ha, Tae Hee Lee, Chang Won Lee
    Diabetes & Metabolism Journal.2016; 40(5): 420.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer