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- Comparison of the Usefulness of the Updated Homeostasis Model Assessment (HOMA2) with the Original HOMA1 in the Prediction of Type 2 Diabetes Mellitus in Koreans
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Young Seok Song, You-Cheol Hwang, Hong-Yup Ahn, Cheol-Young Park
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Diabetes Metab J. 2016;40(4):318-325. Published online May 27, 2016
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DOI: https://doi.org/10.4093/dmj.2016.40.4.318
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Abstract
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- Background
The original homeostasis model assessment (HOMA1) and the updated HOMA model (HOMA2) have been used to evaluate insulin resistance (IR) and β-cell function, but little is known about the usefulness of HOMA2 for the prediction of diabetes in Koreans. The aim of this study was to demonstrate the usefulness of HOMA2 as a predictor of type 2 diabetes mellitus in Koreans without diabetes. MethodsThe study population consisted of 104,694 Koreans enrolled at a health checkup program and followed up from 2001 to 2012. Participants were divided into a normal glucose tolerance (NGT) group and a pre-diabetes group according to fasting glucose and glycosylated hemoglobin levels. Anthropometric and laboratory data were measured at the baseline checkup, and HOMA values were calculated at the baseline and follow-up checkups. The hazard ratios (HRs) of the HOMA1 and HOMA2 values and the prevalence of diabetes at follow-up were evaluated using a multivariable Cox proportional hazards model and Kaplan-Meier analysis. ResultsAfter adjusting for several diabetes risk factors, all of the HOMA values except 1/HOMA1-β and 1/HOMA2-β in the NGT group were significant predictors of the progression to diabetes. In the NGT group, there was no significant difference in HOMA1-IR (HR, 1.09; 95% confidence interval [CI], 1.04 to 1.14) and HOMA2-IR (HR, 1.11; 95% CI, 1.04 to 1.19). However, in the pre-diabetes group, 1/HOMA2-β was a more powerful marker (HR, 1.29; 95% CI, 1.26 to 1.31) than HOMA1-IR (HR, 1.23; 95% CI, 1.19 to 1.28) or 1/HOMA1-β (HR, 1.14; 95% CI, 1.12 to 1.16). In the non-diabetic group (NGT+pre-diabetes), 1/HOMA2-β was also a stronger predictor of diabetes (HR, 1.27; 95% CI, 1.25 to 1.29) than HOMA1-IR (HR, 1.14; 95% CI, 1.12 to 1.15) or 1/HOMA1-β (HR, 1.13; 95% CI, 1.11 to 1.14). ConclusionHOMA2 is more predictive than HOMA1 for the progression to diabetes in pre-diabetes or non-diabetic Koreans.
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- Subphenotypes of adult‐onset diabetes: Data‐driven clustering in the population‐based KORA cohort
Qiuling Dong, Yue Xi, Stefan Brandmaier, Markéta Fuchs, Marie‐Theres Huemer, Melanie Waldenberger, Jiefei Niu, Christian Herder, Wolfgang Rathmann, Michael Roden, Wolfgang Koenig, Gidon J. Bönhof, Christian Gieger, Barbara Thorand, Annette Peters, Susanne Diabetes, Obesity and Metabolism.2025; 27(1): 338. CrossRef - Non-linear associations of HOMA2-IR with all-cause mortality in general populations: insights from NHANES 1999–2006
Aikai Zhang, Lingchen Huang, Min Tang BMC Public Health.2024;[Epub] CrossRef - An acute exercise at low to moderate intensity attenuated postprandial lipemia and insulin responses
Lisa L. Ji, Vicki S. Fretwell, Abel Escamilla, Wanxiang Yao, Tianou Zhang, Meizi He, John Q. Zhang Journal of Exercise Science & Fitness.2024; 22(1): 14. CrossRef - Glutamine Defended the Kidneys Versus Lead Intoxication Via Elevating Endogenous Antioxidants, Reducing Inflammation and Carbonyl Stress, as well as Improving Insulin Resistance and Dyslipidemia
Sina Mahdavifard, Najafzadeh Nowruz Biological Trace Element Research.2024; 202(7): 3141. CrossRef - Insufficient compensatory pancreatic β-cells function might be closely associated with hyperuricemia in U.S. adults: evidence from the National Health and Nutrition Examination Survey
Tianran Shen, Qiutong Zheng, Liling Zhong, Xia Zeng, Xiaojing Yuan, Fengxin Mo, Shiheng Zhu, Wenhan Yang, Qingsong Chen BMC Public Health.2024;[Epub] CrossRef - Glycated haemoglobin, HOMA2‐B, C‐peptide to glucose ratio and type 2 diabetes clusters as predictors for therapy failure in individuals with type 2 diabetes without insulin therapy: A registry analysis
Faisal Aziz, Christoph Sternad, Caren Sourij, Lisa Knoll, Harald Kojzar, Anna Schranz, Alexandra Bürger, Harald Sourij, Felix Aberer Diabetes, Obesity and Metabolism.2024; 26(3): 1082. CrossRef - Nghiên cứu tương quan giữa chỉ số đề kháng insulin và chỉ số khối cơ thể ở bệnh nhân tiền đái tháo đường có tăng huyết áp
Linh Dương Journal of Clinical Medicine- Hue Central Hospital.2024;[Epub] CrossRef - Longitudinal study on hippocampal subfields and glucose metabolism in early psychosis
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Mariana P. Genova, Irena Ivanova, Emilia Naseva, Bisera Atanasova International Journal of Molecular Sciences.2024; 25(22): 12193. CrossRef - Genetic variation in the RETN promoter, accompanied by latent sarcopenic obesity, led to insulin resistance in a Japanese cohort: the Toon Genome Study
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Xu Chen, Jinghe Xiao, Juan Pang, Shen Chen, Qing Wang, Wenhua Ling Nutrients.2021; 13(9): 3139. CrossRef - The correlation between serum resistin and toll-like receptor-4 with insulin resistance in hypertensive subjects with or without type 2 diabetes mellitus
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