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Young Mi Park  (Park YM) 3 Articles
Basic Research
Extracellular Vimentin Alters Energy Metabolism And Induces Adipocyte Hypertrophy
Ji-Hae Park, Soyeon Kwon, Young Mi Park
Diabetes Metab J. 2024;48(2):215-230.   Published online September 26, 2023
DOI: https://doi.org/10.4093/dmj.2022.0332
  • 2,806 View
  • 255 Download
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Previous studies have reported that oxidative stress contributes to obesity characterized by adipocyte hypertrophy. However, mechanism has not been studied extensively. In the current study, we evaluated role of extracellular vimentin secreted by oxidized low-density lipoprotein (oxLDL) in energy metabolism in adipocytes.
Methods
We treated 3T3-L1-derived adipocytes with oxLDL and measured vimentin which was secreted in the media. We evaluated changes in uptake of glucose and free fatty acid, expression of molecules functioning in energy metabolism, synthesis of adenosine triphosphate (ATP) and lactate, markers for endoplasmic reticulum (ER) stress and autophagy in adipocytes treated with recombinant vimentin.
Results
Adipocytes secreted vimentin in response to oxLDL. Microscopic evaluation revealed that vimentin treatment induced increase in adipocyte size and increase in sizes of intracellular lipid droplets with increased intracellular triglyceride. Adipocytes treated with vimentin showed increased uptake of glucose and free fatty acid with increased expression of plasma membrane glucose transporter type 1 (GLUT1), GLUT4, and CD36. Vimentin treatment increased transcription of GLUT1 and hypoxia-inducible factor 1α (Hif-1α) but decreased GLUT4 transcription. Adipose triglyceride lipase (ATGL), peroxisome proliferator-activated receptor γ (PPARγ), sterol regulatory element-binding protein 1 (SREBP1), diacylglycerol O-acyltransferase 1 (DGAT1) and 2 were decreased by vimentin treatment. Markers for ER stress were increased and autophagy was impaired in vimentin-treated adipocytes. No change was observed in synthesis of ATP and lactate in the adipocytes treated with vimentin.
Conclusion
We concluded that extracellular vimentin regulates expression of molecules in energy metabolism and promotes adipocyte hypertrophy. Our results show that vimentin functions in the interplay between oxidative stress and metabolism, suggesting a mechanism by which adipocyte hypertrophy is induced in oxidative stress.
Basic Research
Vimentin Deficiency Prevents High-Fat Diet-Induced Obesity and Insulin Resistance in Mice
SeoYeon Kim, Inyeong Kim, Wonkyoung Cho, Goo Taeg Oh, Young Mi Park
Diabetes Metab J. 2021;45(1):97-108.   Published online June 15, 2020
DOI: https://doi.org/10.4093/dmj.2019.0198
  • 7,664 View
  • 234 Download
  • 18 Web of Science
  • 18 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

Obesity and type 2 diabetes mellitus are world-wide health problems, and lack of understanding of their linking mechanism is one reason for limited treatment options. We determined if genetic deletion of vimentin, a type 3 intermediate filament, affects obesity and type 2 diabetes mellitus.

Methods

We fed vimentin-null (Vim−/−) mice and wild-type mice a high-fat diet (HFD) for 10 weeks and measured weight change, adiposity, blood lipids, and glucose. We performed intraperitoneal glucose tolerance tests and measured CD36, a major fatty acid translocase, and glucose transporter type 4 (GLUT4) in adipocytes from both groups of mice.

Results

Vim−/− mice fed an HFD showed less weight gain, less adiposity, improved glucose tolerance, and lower serum level of fasting glucose. However, serum triglyceride and non-esterified fatty acid levels were higher in Vim−/− mice than in wild-type mice. Vimentin-null adipocytes showed 41.1% less CD36 on plasma membranes, 27% less uptake of fatty acids, and 50.3% less GLUT4, suggesting defects in intracellular trafficking of these molecules.

Conclusion

We concluded that vimentin deficiency prevents obesity and insulin resistance in mice fed an HFD and suggest vimentin as a central mediator linking obesity and type 2 diabetes mellitus.

Citations

Citations to this article as recorded by  
  • Extracellular Vimentin Alters Energy Metabolism And Induces Adipocyte Hypertrophy
    Ji-Hae Park, Soyeon Kwon, Young Mi Park
    Diabetes & Metabolism Journal.2024; 48(2): 215.     CrossRef
  • Neutrophils display distinct post-translational modifications in response to varied pathological stimuli
    Pooja Yedehalli Thimmappa, Aswathy S Nair, Sian D'silva, Anjana Aravind, Sandeep Mallya, Sreelakshmi Pathappillil Soman, Kanive Parashiva Guruprasad, Shamee Shastry, Rajesh Raju, Thottethodi Subrahmanya Keshava Prasad, Manjunath B Joshi
    International Immunopharmacology.2024; 132: 111950.     CrossRef
  • 92A Systematic Review of Proteomics in Obesity: Unpacking the Molecular Puzzle
    Alba Rodriguez-Muñoz, Hanieh Motahari-Rad, Laura Martin-Chaves, Javier Benitez-Porres, Jorge Rodriguez-Capitan, Andrés Gonzalez-Jimenez, Maria Insenser, Francisco J. Tinahones, Mora Murri
    Current Obesity Reports.2024;[Epub]     CrossRef
  • Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity
    Tamara Camino, Nerea Lago-Baameiro, María Pardo
    Biomedicines.2023; 11(2): 422.     CrossRef
  • Bioinformatics and Next-Generation Data Analysis for Identification of Genes and Molecular Pathways Involved in Subjects with Diabetes and Obesity
    Prashanth Ganekal, Basavaraj Vastrad, Satish Kavatagimath, Chanabasayya Vastrad, Shivakumar Kotrashetti
    Medicina.2023; 59(2): 309.     CrossRef
  • Modified Signaling of Membrane Formyl Peptide Receptors in NADPH-Oxidase Regulation in Obesity-Resistant Mice
    Irina Tikhonova, Alsu Dyukina, Elvira Shaykhutdinova, Valentina Safronova
    Membranes.2023; 13(3): 306.     CrossRef
  • Plasma Cytokeratin-18 Fragment Level Reflects the Metabolic Phenotype in Obesity
    Joanna Goralska, Urszula Razny, Anna Gruca, Anna Zdzienicka, Agnieszka Micek, Aldona Dembinska-Kiec, Bogdan Solnica, Malgorzata Malczewska-Malec
    Biomolecules.2023; 13(4): 675.     CrossRef
  • Blueberry and Blackberry Anthocyanins Ameliorate Metabolic Syndrome by Modulating Gut Microbiota and Short-Chain Fatty Acids Metabolism in High-Fat Diet-Fed C57BL/6J Mice
    Lanlan Du, Han Lü, Yan Chen, Xiaohua Yu, Tunyu Jian, Huifang Zhao, Wenlong Wu, Xiaoqin Ding, Jian Chen, Weilin Li
    Journal of Agricultural and Food Chemistry.2023; 71(40): 14649.     CrossRef
  • An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis
    Sara KM Jörgensen, Alena Karnošová, Simone Mazzaferro, Oliver Rowley, Hsiao-Jou Cortina Chen, Sarah J Robbins, Sarah Christofides, Florian T Merkle, Lenka Maletínská, David Petrik
    EMBO Reports.2023; 25(1): 351.     CrossRef
  • Cytoskeleton alterations in non-alcoholic fatty liver disease
    João Pessoa, José Teixeira
    Metabolism.2022; 128: 155115.     CrossRef
  • Recent Advances in the Treatment of Insulin Resistance Targeting Molecular and Metabolic Pathways: Fighting a Losing Battle?
    Marta Wolosowicz, Slawomir Prokopiuk, Tomasz W. Kaminski
    Medicina.2022; 58(4): 472.     CrossRef
  • Roles of vimentin in health and disease
    Karen M. Ridge, John E. Eriksson, Milos Pekny, Robert D. Goldman
    Genes & Development.2022; 36(7-8): 391.     CrossRef
  • Plasma Membrane Localization of CD36 Requires Vimentin Phosphorylation; A Mechanism by Which Macrophage Vimentin Promotes Atherosclerosis
    Seo Yeon Kim, Se-Jin Jeong, Ji-Hae Park, Wonkyoung Cho, Young-Ho Ahn, Youn-Hee Choi, Goo Taeg Oh, Roy L. Silverstein, Young Mi Park
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Camel Proteins and Enzymes: A Growing Resource for Functional Evolution and Environmental Adaptation
    Mahmoud Kandeel, Abdulla Al-Taher, Katharigatta N. Venugopala, Mohamed Marzok, Mohamed Morsy, Sreeharsha Nagaraja
    Frontiers in Veterinary Science.2022;[Epub]     CrossRef
  • Brown Adipose Tissue Sheds Extracellular Vesicles That Carry Potential Biomarkers of Metabolic and Thermogenesis Activity Which Are Affected by High Fat Diet Intervention
    Tamara Camino, Nerea Lago-Baameiro, Aurelio Sueiro, Susana Belén Bravo, Iván Couto, Francisco Fernando Santos, Javier Baltar, Felipe F. Casanueva, María Pardo
    International Journal of Molecular Sciences.2022; 23(18): 10826.     CrossRef
  • Dietary tea seed saponin combined with aerobic exercise attenuated lipid metabolism and oxidative stress in mice fed a high‐fat diet (HFD)
    Wenjing Cao, Keying Wang, Chanhua Liang, Yanming Su, Shuang Liu, Jiali Li, Huishan Qing, Zhen Zeng, Ling Dai, Jia‐Le Song
    Journal of Food Biochemistry.2022;[Epub]     CrossRef
  • Influence of Protein Carbonylation on Human Adipose Tissue Dysfunction in Obesity and Insulin Resistance
    M. Carmen Navarro-Ruiz, M. Carmen Soler-Vázquez, Alberto Díaz-Ruiz, Juan R. Peinado, Andrea Nieto Calonge, Julia Sánchez-Ceinos, Carmen Tercero-Alcázar, Jaime López-Alcalá, Oriol A. Rangel-Zuñiga, Antonio Membrives, José López-Miranda, María M. Malagón, R
    Biomedicines.2022; 10(12): 3032.     CrossRef
  • The Role of Adipose Tissue Lipolysis in Diet-Induced Obesity: Focus on Vimentin
    Eun Roh, Hye Jin Yoo
    Diabetes & Metabolism Journal.2021; 45(1): 43.     CrossRef
A Survey of Diabetic Educators and Patients for the Revision of Korean Food Exchange Lists
Jae Won Cho, Mee Ra Kweon, Young Mi Park, Mi Hye Woo, Hye Sook Yoo, Jeong Hyun Lim, Bo Kyung Koo, Chong Hwa Kim, Hae Jin Kim, Tae Sun Park, Choong Ho Shin, Kyu Chang Won, Soo Lim, Hak Chul Jang
Diabetes Metab J. 2011;35(2):173-181.   Published online April 30, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.2.173
  • 4,832 View
  • 39 Download
  • 6 Crossref
AbstractAbstract PDFPubReader   
Background

Food exchange lists are one of the main methods of nutritional education. However, Korean food exchange lists have not been revised since 1994. Therefore, we surveyed the opinions of diabetes educators and patients with diabetes regarding the need for revision of the current food exchange lists.

Methods

For two weeks beginning on 10 March 2008, a 12-item questionnaire regarding the opinion and need for revision of the current food exchange lists was e-mailed to diabetes educators nationwide. Another 15-question survey was administered to patients with diabetes in 13 hospitals located in the Seoul and Gyeonggi regions of Korea.

Results

We obtained survey responses from 101 diabetes educators and 209 patients; 65 (64.3%) of the educators answered that the current food exchange lists should be revised. The items that needed revision were the glycemic index, addition of new foods and reaffirmation of exchange standard amounts. The patients demanded specific education about choosing appropriate foods, a balanced meal plan, proper snacks, and dining intake.

Conclusion

Our survey results demonstrate the need to revise the Korean food exchange lists. This process should focus on glycemic index, the addition of new foods and reconfirmation of one exchange reference unit.

Citations

Citations to this article as recorded by  
  • Mediterranean Diet and Naltrexone/Bupropion Treatment for Weight Loss in Overweight and Obese Breast Cancer Survivors and Non-Cancer Participants: A Pilot Randomized Controlled Trial


    A-Ra Cho, Won-Jun Choi, Yu-Jin Kwon, Hye Sun Lee, Sung Gwe Ahn, Ji-Won Lee
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 3325.     CrossRef
  • Development of a Spanish Food Exchange List: Application of Statistical Criteria to a Rationale Procedure
    Iva Marques-Lopes, Susana Menal-Puey, J. Alfredo Martínez, Giuseppe Russolillo
    Journal of the Academy of Nutrition and Dietetics.2018; 118(7): 1161.     CrossRef
  • A Practical Approach to the Management of Micronutrients and Other Nutrients of Concern in Food Exchange Lists for Meal Planning
    Giuseppe Russolillo-Femenías, Susana Menal-Puey, J. Alfredo Martínez, Iva Marques-Lopes
    Journal of the Academy of Nutrition and Dietetics.2018; 118(11): 2029.     CrossRef
  • How much fruit should diabetic patients eat?
    Jeong Hyun Lim
    The Journal of Korean Diabetes.2014; 15(4): 185.     CrossRef
  • Korean Food Exchange Lists for Diabetes: Revised 2010
    Dal Lae Ju, Hak Chul Jang, Young Yun Cho, Jae Won Cho, Hye Sook Yoo, Kyung Suk Choi, Mi Hye Woo, Cheong Min Sohn, Yoo Kyoung Park, Ryo Won Choue
    Journal of Korean Diabetes.2011; 12(4): 228.     CrossRef
  • Korean Food Exchange Lists for Diabetes: Revised 2010
    Dal Lae Ju, Hak Chul Jang, Young Yun Cho, Jae Won Cho, Hye Sook Yoo, Kyung Suk Choi, Mi Hye Woo, Cheong Min Sohn, Yoo Kyoung Park, Ryowon Choue
    The Korean Journal of Nutrition.2011; 44(6): 577.     CrossRef

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