Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal


Author index

Page Path
HOME > Browse > Author index
Yongmin Kwon  (Kwon Y) 1 Article
Basic Research
Role of CRTC2 in Metabolic Homeostasis: Key Regulator of Whole-Body Energy Metabolism?
Hye-Sook Han, Yongmin Kwon, Seung-Hoi Koo
Diabetes Metab J. 2020;44(4):498-508.   Published online March 5, 2020
  • 6,883 View
  • 162 Download
  • 14 Web of Science
  • 16 Crossref
AbstractAbstract PDFPubReader   ePub   

Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription coactivator (CRTC), is essential for controlling the expression of critical enzymes in the metabolic process, leading to more chronic changes in metabolic flux. Among the CRTC isoforms, CRTC2 is predominantly expressed in peripheral tissues and has been shown to be associated with various metabolic pathways in tissue-specific manners. While initial reports showed the physiological role of CRTC2 in regulating gluconeogenesis in the liver, recent studies have further delineated the role of this transcriptional coactivator in the regulation of glucose and lipid metabolism in various tissues, including the liver, pancreatic islets, endocrine tissues of the small intestines, and adipose tissues. In this review, we discuss recent studies that have utilized knockout mouse models to delineate the role of CRTC2 in the regulation of metabolic homeostasis.


Citations to this article as recorded by  
  • Integration of genomic and transcriptomic data of inbred mouse models for polygenic obesity and leanness revealed “obese” and “lean” candidate alleles in polyadenylation signals
    Martin Šimon, Špela Mikec, Nicholas M. Morton, Santosh S. Atanur, Simon Horvat, Tanja Kunej
    Gene Reports.2024; 35: 101903.     CrossRef
  • Mylabris phalerata induces the apoptosis and cell cycle delay in HCC, and potentiates the effect of sorafenib based on the molecular and network pharmacology approach
    Young Woo Kim, Seon Been Bak, Su Youn Baek, Il Kon Kim, Won-Yung Lee, Un-Jung Yun, Kwang-Il Park
    Molecular & Cellular Toxicology.2023; 19(4): 731.     CrossRef
  • Emerging Role of SMILE in Liver Metabolism
    Nanthini Sadasivam, Kamalakannan Radhakrishnan, Hueng-Sik Choi, Don-Kyu Kim
    International Journal of Molecular Sciences.2023; 24(3): 2907.     CrossRef
  • PIMT regulates hepatic gluconeogenesis in mice
    Bandish Kapadia, Soma Behera, Sireesh T. Kumar, Tapan Shah, Rebecca Kristina Edwin, Phanithi Prakash Babu, Partha Chakrabarti, Kishore V.L. Parsa, Parimal Misra
    iScience.2023; 26(3): 106120.     CrossRef
  • Biological functions of CRTC2 and its role in metabolism-related diseases
    Hong-Yu Zheng, Yan-Xia Wang, Kun Zhou, Hai-Lin Xie, Zhong Ren, Hui-Ting Liu, Yang-Shao Ou, Zhi-Xiang Zhou, Zhi-Sheng Jiang
    Journal of Cell Communication and Signaling.2023; 17(3): 495.     CrossRef
  • An insulin-regulated arrestin domain protein controls hepatic glucagon action
    Sezin Dagdeviren, Megan F. Hoang, Mohsen Sarikhani, Vanessa Meier, Jake C. Benoit, Marinna C. Okawa, Veronika Y. Melnik, Elisabeth M. Ricci-Blair, Natalie Foot, Randall H. Friedline, Xiaodi Hu, Lauren A. Tauer, Arvind Srinivasan, Maxim B. Prigozhin, Sudha
    Journal of Biological Chemistry.2023; 299(8): 105045.     CrossRef
  • The Pleiotropic Face of CREB Family Transcription Factors
    Md. Arifur Rahman Chowdhury, Jungeun An, Sangyun Jeong
    Molecules and Cells.2023; 46(7): 399.     CrossRef
  • It is a branched road to adipose tissue aging
    N. Touitou, B. Lerrer, H. Y. Cohen
    Nature Aging.2023; 3(8): 911.     CrossRef
  • Impaired BCAA catabolism in adipose tissues promotes age-associated metabolic derangement
    Hye-Sook Han, Eunyong Ahn, Eun Seo Park, Tom Huh, Seri Choi, Yongmin Kwon, Byeong Hun Choi, Jueun Lee, Yoon Ha Choi, Yujin L. Jeong, Gwang Bin Lee, Minji Kim, Je Kyung Seong, Hyun Mu Shin, Hang-Rae Kim, Myeong Hee Moon, Jong Kyoung Kim, Geum-Sook Hwang, S
    Nature Aging.2023; 3(8): 982.     CrossRef
  • Exploring the diagnostic value, prognostic value, and biological functions of NPC gene family members in hepatocellular carcinoma based on a multi-omics analysis
    Keheng Chen, Xin Zhang, Huixin Peng, Fengdie Huang, Guangyu Sun, Qijiang Xu, Lusheng Liao, Zhiyong Xing, Yanping Zhong, Zhichao Fang, Meihua Liao, Shihua Luo, Wencheng Chen, Mingyou Dong
    Functional & Integrative Genomics.2023;[Epub]     CrossRef
  • MicroRNA regulation of AMPK in nonalcoholic fatty liver disease
    Hao Sun, Jongsook Kim Kemper
    Experimental & Molecular Medicine.2023; 55(9): 1974.     CrossRef
  • Serine active site containing protein 1 depletion alters lipid metabolism and protects against high fat diet-induced obesity in mice
    Miaomiao Du, Xueyun Li, Fangyi Xiao, Yinxu Fu, Yu Shi, Sihan Guo, Lifang Chen, Lu Shen, Lan Wang, Huang Cheng, Hao Li, Anran Xie, Yaping Zhou, Kaiqiang Yang, Hezhi Fang, Jianxin Lyu, Qiongya Zhao
    Metabolism.2022; 134: 155244.     CrossRef
  • cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach
    Muhammad Bilal Ahmed, Abdullah A. A. Alghamdi, Salman Ul Islam, Joon-Seok Lee, Young-Sup Lee
    Cells.2022; 11(13): 2020.     CrossRef
  • Hepatic Sam68 Regulates Systemic Glucose Homeostasis and Insulin Sensitivity
    Aijun Qiao, Wenxia Ma, Ying Jiang, Chaoshan Han, Baolong Yan, Junlan Zhou, Gangjian Qin
    International Journal of Molecular Sciences.2022; 23(19): 11469.     CrossRef
  • The Role of Small Heterodimer Partner-Interacting Leucine Zipper (SMILE) as a Transcriptional Corepressor in Hepatic Glucose and Lipid Metabolism
    Woo-Ram Park, Byungyoon Choi, Nanthini Sadasivam, Don-Kyu Kim
    Trends in Agriculture & Life Sciences.2022; 60: 7.     CrossRef
  • AMPK Localization: A Key to Differential Energy Regulation
    Qonita Afinanisa, Min Kyung Cho, Hyun-A Seong
    International Journal of Molecular Sciences.2021; 22(20): 10921.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal