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Yaeko Fukushima  (Fukushima Y) 2 Articles
Obesity and Metabolic Syndrome
Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects
Yaeko Fukushima, Satoshi Kurose, Hiromi Shinno, Ha Cao Thi Thu, Nana Takao, Hiromi Tsutsumi, Takaaki Hasegawa, Toshiaki Nakajima, Yutaka Kimura
Diabetes Metab J. 2016;40(5):386-395.   Published online September 27, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.5.386
  • 6,042 View
  • 50 Download
  • 31 Web of Science
  • 29 Crossref
AbstractAbstract PDFPubReader   
Background

Irisin is a myokine implicated in lipid and glucose metabolism. The objective of this study is to examine the effect of a body weight reduction on the serum irisin level and physical indicators in obese Japanese patients without diabetes.

Methods

The subjects were 22 patients (male/female, 5/17; age, 46.1±16.0 years; body mass index [BMI], 36.9±5.0 kg/m2) who completed a 6-month body weight reduction program at our clinic. The program included diet, exercise therapy and cognitive behavioral therapy. Blood parameters, body composition, exercise tolerance, homeostasis model assessment of insulin resistance (HOMA-IR), and serum irisin were determined before and after intervention, and relationships among changes in these data were examined.

Results

There were significant decreases in body weight and BMI after the intervention. Irisin before the intervention was significantly positively correlated with HOMA-IR (r=0.434, P<0.05). The mean irisin level showed no significant change after the intervention in all participants. However, improvements in % body fat, subcutaneous fat area, triglycerides, and fasting glucose were significantly greater in patients with an increase in irisin compared to those with a decrease in irisin after the intervention. Patients with an increase in irisin also had significantly lower fasting insulin (9.7±4.8 vs. 16.4±8.2, P<0.05) and HOMA-IR (2.2±1.1 vs. 3.7±1.6, P<0.05) after the intervention, compared to patients with a decrease in irisin.

Conclusion

Body weight reduction did not alter irisin levels. However, irisin may play important roles in fat and glucose metabolism and insulin resistance, and the effects of body weight reduction on irisin kinetics may be a key for obesity treatment.

Citations

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  • Effects of 12-Week Tabata Training on Selected Health-Related Fitness Component in Healthy Untrained Students from Malaysia
    N. M. Sukri, A. Ahmad, N. A. Roos, M. F. Nordin, F. N. Halim, J. V. Gnanou, F. A. Manaf
    Journal of Science in Sport and Exercise.2024;[Epub]     CrossRef
  • Association between changes in body composition and progression of liver fibrosis in patients with type 2 diabetes mellitus
    Yuxi Lin, Zhixing Liang, Xiaofang Liu, Yutian Chong
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • Correlations between serum testosterone and irisin levels in a sample of Egyptian men with metabolic syndrome; (case-control study)
    Inass Hassan Ahmad, Eman Roshdy Mohamed Mostafa, Shymaa Abdelhafeez Mohammed, Walaa Shipl, Amany Ahmed Soliman, Marwa Said
    Archives of Physiology and Biochemistry.2023; 129(1): 180.     CrossRef
  • The Effect of Bariatric Surgery on Irisin Level: a Systematic Review and Meta-analysis
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    Obesity Surgery.2023; 33(10): 3256.     CrossRef
  • Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity
    Young-Chan Kim, Sang-Woo Ki, Hannah Kim, Sumin Kang, Hayoon Kim, Gwang-woong Go
    Nutrients.2023; 15(17): 3854.     CrossRef
  • Effect of Eccentric Exercise on Metabolic Health in Diabetes and Obesity
    Gergő Szűcs, Márton Pipicz, Márton Richárd Szabó, Tamás Csont, László Török, Csaba Csonka
    Sports Medicine - Open.2023;[Epub]     CrossRef
  • An early prediction model for gestational diabetes mellitus based on genetic variants and clinical characteristics in China
    Qi Wu, Yanmin Chen, Menglin Zhou, Mengting Liu, Lixia Zhang, Zhaoxia Liang, Danqing Chen
    Diabetology & Metabolic Syndrome.2022;[Epub]     CrossRef
  • Evaluation of vaspin and irisin hormones levels in diabetic rats and relationship with diet
    Sergen Tuğgüm, Çiğdem Bozkır, Serkan Aslan, Ahsen Yılmaz, Aliye Çelikkol
    Mediterranean Journal of Nutrition and Metabolism.2022; 15(3): 419.     CrossRef
  • Biological Response of Irisin Induced by Different Types of Exercise in Obese Subjects: A Non-Inferiority Controlled Randomized Study
    Andrea D’Amuri, Valeria Raparelli, Juana Maria Sanz, Eleonora Capatti, Francesca Di Vece, Filippo Vaccari, Stefano Lazzer, Giovanni Zuliani, Edoardo Dalla Nora, Luca Maria Neri, Angelina Passaro
    Biology.2022; 11(3): 392.     CrossRef
  • The role of exercise-induced myokines in promoting angiogenesis
    Chao Qi, Xianjing Song, He Wang, Youyou Yan, Bin Liu
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Effectiveness of companion-intensive multi-aspect weight management in Chinese adults with obesity: a 6-month multicenter randomized clinical trial
    Wanzi Jiang, Shushu Huang, Shuai Ma, Yingyun Gong, Zhenzhen Fu, Li Zhou, Wen Hu, Guofang Mao, Zhimin Ma, Ling Yang, Guangfeng Tang, Xiaofang Sun, Ping Zhang, Jianling Bai, Lei Chen, Bimin Shi, Xinhua Ye, Hongwen Zhou
    Nutrition & Metabolism.2021;[Epub]     CrossRef
  • Progress and Challenges in the Biology of FNDC5 and Irisin
    Steffen Maak, Frode Norheim, Christian A Drevon, Harold P Erickson
    Endocrine Reviews.2021; 42(4): 436.     CrossRef
  • Role of Irisin in Endocrine and Metabolic Disorders—Possible New Therapeutic Agent?
    Letitia Leustean, Cristina Preda, Laura Teodoriu, Laura Mihalache, Lidia Arhire, Maria-Christina Ungureanu
    Applied Sciences.2021; 11(12): 5579.     CrossRef
  • The Physiological Role of Irisin in the Regulation of Muscle Glucose Homeostasis
    Naohiro Yano, Yu Tina Zhao, Ting C. Zhao
    Endocrines.2021; 2(3): 266.     CrossRef
  • Irisin, interleukin-33 and interleukin-37 in patients with ischemic heart disease and obesity
    Yuliia Kovalova, Nataliia Sukhonos, Valeriia Brek, Kateryna Smolianyk
    Medicinski casopis.2021; 55(3): 87.     CrossRef
  • Synergism Effects of Ursolic Acid Supplementation on the Levels of Irisin, C-reactive Protein, IL-6, and TNF-α During High-intensity Resistance Training in Low Activity Men
    Ehsan Asghari, Amir Rashidlamir, Seyyed R.A. Hosseini, Mahtab Moazzami, Saeed Samarghandian, Tahereh Farkhondeh
    Cardiovascular & Hematological Disorders-Drug Targets .2020; 20(2): 138.     CrossRef
  • Exercise-Induced Circulating Irisin Level Is Correlated with Improved Cardiac Function in Rats
    Dae Yun Seo, Jun Hyun Bae, Tae Nyun Kim, Hyo-Bum Kwak, Pham Trong Kha, Jin Han
    International Journal of Environmental Research and Public Health.2020; 17(11): 3863.     CrossRef
  • Effect of HIIT with Tabata Protocol on Serum Irisin, Physical Performance, and Body Composition in Men
    Eugenia Murawska-Cialowicz, Pawel Wolanski, Jolanta Zuwala-Jagiello, Yuri Feito, Miroslav Petr, Jakub Kokstejn, Petr Stastny, Dawid Goliński
    International Journal of Environmental Research and Public Health.2020; 17(10): 3589.     CrossRef
  • Serum Irisin, Adropin, and Preptin in Obese Patients 6 Months After Bariatric Surgery
    M. Glück, J. Glück, M. Wiewióra, B. Rogala, J. Piecuch
    Obesity Surgery.2019; 29(10): 3334.     CrossRef
  • A Novel Interplay Between Irisin and PTH: From Basic Studies to Clinical Evidence in Hyperparathyroidism
    Andrea Palermo, Lorenzo Sanesi, Graziana Colaianni, Gaia Tabacco, Anda Mihaela Naciu, Roberto Cesareo, Claudio Pedone, Diana Lelli, Giacomina Brunetti, Giorgio Mori, Silvia Colucci, Silvia Manfrini, Nicola Napoli, Maria Grano
    The Journal of Clinical Endocrinology & Metabolism.2019; 104(8): 3088.     CrossRef
  • Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement
    Hossein Shirvani, Saleh Rahmati-Ahmadabad
    Lipids in Health and Disease.2019;[Epub]     CrossRef
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    Hossein Shirvani, Saleh Rahmati-Ahmadabad, David Robert Broom, Reza Mirnejad
    Journal of Experimental Biology.2019;[Epub]     CrossRef
  • Colostrum and mature breast milk analysis of serum irisin and sterol regulatory element-binding proteins-1c in gestational diabetes mellitus
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    The Journal of Maternal-Fetal & Neonatal Medicine.2019; 32(18): 2993.     CrossRef
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    Acta Chirurgica Belgica.2019; 119(6): 363.     CrossRef
  • Increase in relative skeletal muscle mass over time and its inverse association with metabolic syndrome development: a 7-year retrospective cohort study
    Gyuri Kim, Seung-Eun Lee, Ji Eun Jun, You-Bin Lee, Jiyeon Ahn, Ji Cheol Bae, Sang-Man Jin, Kyu Yeon Hur, Jae Hwan Jee, Moon-Kyu Lee, Jae Hyeon Kim
    Cardiovascular Diabetology.2018;[Epub]     CrossRef
  • Association of serum concentrations of irisin and the adipokines adiponectin and leptin with epicardial fat in cardiovascular surgery patients
    Hiroyuki Kaneda, Toshiaki Nakajima, Akiko Haruyama, Ikuko Shibasaki, Takaaki Hasegawa, Tatsuya Sawaguchi, Toshiyuki Kuwata, Syoutarou Obi, Takuo Arikawa, Masashi Sakuma, Hirohisa Amano, Shigeru Toyoda, Hirotsugu Fukuda, Teruo Inoue, Luca Vanella
    PLOS ONE.2018; 13(8): e0201499.     CrossRef
  • Relationship Between Relative Skeletal Muscle Mass and Nonalcoholic Fatty Liver Disease: A 7‐Year Longitudinal Study
    Gyuri Kim, Seung‐Eun Lee, You‐Bin Lee, Ji Eun Jun, Jiyeon Ahn, Ji Cheol Bae, Sang‐Man Jin, Kyu Yeon Hur, Jae Hwan Jee, Moon‐Kyu Lee, Jae Hyeon Kim
    Hepatology.2018; 68(5): 1755.     CrossRef
  • Effect of exercise on concentrations of irisin in overweight individuals: A systematic review
    P. Amaro Andrade, B.K. Souza Silveira, A. Corrêa Rodrigues, F.M. Oliveira da Silva, C.O. Barbosa Rosa, R.C. Gonçalves Alfenas
    Science & Sports.2018; 33(2): 80.     CrossRef
  • Is irisin the new player in exercise-induced adaptations or not? A 2017 update
    Ioannis G. Fatouros
    Clinical Chemistry and Laboratory Medicine (CCLM).2018; 56(4): 525.     CrossRef
Obesity and Metabolic Syndrome
Importance of Lean Muscle Maintenance to Improve Insulin Resistance by Body Weight Reduction in Female Patients with Obesity
Yaeko Fukushima, Satoshi Kurose, Hiromi Shinno, Ha Cao Thu, Nana Takao, Hiromi Tsutsumi, Yutaka Kimura
Diabetes Metab J. 2016;40(2):147-153.   Published online March 27, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.2.147
  • 4,739 View
  • 52 Download
  • 30 Web of Science
  • 29 Crossref
AbstractAbstract PDFPubReader   
Background

It has recently been suggested that skeletal muscle has an important role in insulin resistance in obesity, in addition to exercise tolerance and the fat index. The aim of this study was to identify body composition factors that contribute to improvement of insulin resistance in female patients with obesity who reduce body weight.

Methods

We studied 92 female obese patients (age 40.9±10.4 years, body mass index 33.2±4.6 kg/m2) who reduced body weight by ≥5% after an intervention program including diet, exercise therapy, and cognitive behavioral therapy. Before and after the intervention, body composition was evaluated by dual-energy X-ray absorptiometry to examine changes in skeletal muscle mass. Homeostasis model assessment of insulin resistance (HOMA-IR) was measured as an index of insulin resistance. Cardiopulmonary exercise was also performed by all patients.

Results

There were significant improvements in body weight (–10.3%±4.5%), exercise tolerance (anaerobic threshold oxygen uptake 9.1%±18.4%, peak oxygen uptake 11.0%±14.2%), and HOMA-IR (–20.2%±38.3%). Regarding body composition, there were significant decreases in total body fat (–19.3%±9.6%), total fat-free mass (–2.7%±4.3%), and % body fat (–10.1%±7.5%), whereas % skeletal muscle significantly increased (8.9%±7.2%). In stepwise multiple linear regression analysis with change in HOMA-IR as the dependent variable, the change in % skeletal muscle was identified as an independent predictor (β=–0.280, R2=0.068, P<0.01).

Conclusion

Improvement of insulin resistance in female obese patients requires maintenance of skeletal muscle mass.

Citations

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  • Sarcopenia prevalence between obese and morbid obese patients in an obesity center
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    Journal of Surgery and Medicine.2024; 8(4): 73.     CrossRef
  • Association between insulin sensitivity and lean mass loss during weight loss
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    Obesity.2024; 32(6): 1156.     CrossRef
  • Dietary behaviour change intervention for managing sarcopenic obesity among community-dwelling older people: a pilot randomised controlled trial
    Yue-Heng Yin, Justina Yat Wa Liu, Maritta Välimäki
    BMC Geriatrics.2023;[Epub]     CrossRef
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    Seminars in Reproductive Medicine.2023; 41(01/02): 026.     CrossRef
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    Yoshinari Matsumoto, Satoshi Kurose, Takumi Miyauchi, Sawako Yoshiuchi, Daiki Habu, Yutaka Kimura
    Journal of Physical Activity and Health.2022; 19(5): 351.     CrossRef
  • Interrelationship of Gut Microbiota, Obesity, Body Composition and Insulin Resistance in Asians with Type 2 Diabetes Mellitus
    Che-Sheng Pai, Cheng-Yuan Wang, Wei-Wen Hung, Wei-Chun Hung, Hui-Ju Tsai, Chen-Chia Chang, Shang-Jyh Hwang, Chia-Yen Dai, Wen-Yu Ho, Yi-Chun Tsai
    Journal of Personalized Medicine.2022; 12(4): 617.     CrossRef
  • Exercise and Nutrition Strategies for Combating Sarcopenia and Type 2 Diabetes Mellitus in Older Adults
    Dionysia Argyropoulou, Nikolaos D. Geladas, Tzortzis Nomikos, Vassilis Paschalis
    Journal of Functional Morphology and Kinesiology.2022; 7(2): 48.     CrossRef
  • Branched-Chain and Aromatic Amino Acids in Relation to Fat Mass and Fat-Free Mass Changes among Adolescents: A School-Based Intervention
    Magnoudewa Priscille Pana, Pierre Ayotte, Elhadji Anassour-Laouan-Sidi, Edouard Suhas, Clémence Mahana Iti Gatti, Michel Lucas
    Metabolites.2022; 12(7): 589.     CrossRef
  • Exercising for Insulin Sensitivity – Is There a Mechanistic Relationship With Quantitative Changes in Skeletal Muscle Mass?
    Jasmine Paquin, Jean-Christophe Lagacé, Martin Brochu, Isabelle J. Dionne
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • The relationship between changes in serum myostatin and adiponectin levels in patients with obesity undergoing a weight loss program
    Nana Takao, Satoshi Kurose, Takumi Miyauchi, Katsuko Onishi, Atsuko Tamanoi, Ryota Tsuyuguchi, Aya Fujii, Sawako Yoshiuchi, Kazuhisa Takahashi, Hiromi Tsutsumi, Yutaka Kimura
    BMC Endocrine Disorders.2021;[Epub]     CrossRef
  • Exercise induces favorable metabolic changes in white adipose tissue preventing high‐fat diet obesity
    Babu R. Maharjan, Sergio F. Martinez‐Huenchullan, Susan V. Mclennan, Stephen M. Twigg, Paul F. Williams
    Physiological Reports.2021;[Epub]     CrossRef
  • THE RELATIONSHIP BETWEEN INSULIN RESISTANCE AND FA-TIGUE SYMPTOM IN FIBROMYALGIA SYNDROME
    Türkan Turgay, Zekiye İpek Katirci Kirmaci, Pınar Günel Karadeniz, Mehmet Baştemir
    International Journal of Research -GRANTHAALAYAH.2020; 8(3): 271.     CrossRef
  • Epicardial adipose tissue is tightly associated with exercise intolerance in patients with type 2 diabetes mellitus with asymptomatic left ventricular structural and functional abnormalities
    Yousuke Sugita, Katsuhiko Ito, Shigeki Sakurai, Satoshi Sakai, Shinya Kuno
    Journal of Diabetes and its Complications.2020; 34(5): 107552.     CrossRef
  • Dose Frequency Optimization of the Dual Amylin and Calcitonin Receptor Agonist KBP-088: Long-Lasting Improvement in Food Preference and Body Weight Loss
    Anna Thorsø Larsen, Nina Sonne, Kim V. Andreassen, Morten A. Karsdal, Kim Henriksen
    Journal of Pharmacology and Experimental Therapeutics.2020; 373(2): 269.     CrossRef
  • Healthy dietary pattern and their corresponding gut microbiota profile are linked to a lower risk of type 2 diabetes, independent of the presence of obesity
    D.A. Díaz-Rizzolo, B. Kostov, M. López-Siles, A. Serra, C. Colungo, L. González-de-Paz, M. Martinez-Medina, A. Sisó-Almirall, R. Gomis
    Clinical Nutrition.2020; 39(2): 524.     CrossRef
  • Changes in Body Composition and FTO Whole Blood DNA Methylation Among Japanese Women: A Randomized Clinical Trial of Weight-Loss Program


    Haruhiko Nishida, Katsuko Onishi, Satoshi Kurose, Hiromi Tsutsumi, Takumi Miyauchi, Nana Takao, Sawako Yoshiuchi, Aya Fujii, Yutaka Kimura
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 2157.     CrossRef
  • Effects of low skeletal muscle mass and sarcopenic obesity on albuminuria: a 7-year longitudinal study
    Jee Hee Yoo, Gyuri Kim, Sung Woon Park, Min Sun Choi, Jiyeon Ahn, Sang-Man Jin, Kyu Yeon Hur, Moon-Kyu Lee, Mira Kang, Jae Hyeon Kim
    Scientific Reports.2020;[Epub]     CrossRef
  • Effects of body weight loss program on parameters of muscle performance in female obese adults
    Gian Pietro Emerenziani, Dafne Ferrari, Silvia Migliaccio, Andrea Lenzi, Emanuela A. Greco, Chiara Marocco, Carlo Baldari, Laura Guidetti
    The Journal of Sports Medicine and Physical Fitness.2019;[Epub]     CrossRef
  • Reduced Lean Body Mass and Cardiometabolic Diseases in Adult Males with Overweight and Obesity: A Pilot Study
    Shirine Khazem, Leila Itani, Dima Kreidieh, Dana El Masri, Hana Tannir, Roberto Citarella, Marwan El Ghoch
    International Journal of Environmental Research and Public Health.2018; 15(12): 2754.     CrossRef
  • Physical performance measures in screening for reduced lean body mass in adult females with obesity
    M. El Ghoch, A.P. Rossi, S. Calugi, S. Rubele, F. Soave, M. Zamboni, E. Chignola, G. Mazzali, P.V. Bazzani, R. Dalle Grave
    Nutrition, Metabolism and Cardiovascular Diseases.2018; 28(9): 917.     CrossRef
  • Testosterone a key factor in gender related metabolic syndrome
    V. E. Bianchi, V. Locatelli
    Obesity Reviews.2018; 19(4): 557.     CrossRef
  • Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2
    Cailu Lin, Brad D. Fesi, Michael Marquis, Natalia P. Bosak, Anna Lysenko, Mohammed Amin Koshnevisan, Fujiko F. Duke, Maria L. Theodorides, Theodore M. Nelson, Amanda H. McDaniel, Mauricio Avigdor, Charles J. Arayata, Lauren Shaw, Alexander A. Bachmanov, D
    Mammalian Genome.2018; 29(5-6): 325.     CrossRef
  • Hypoxic Training Improves Normoxic Glucose Tolerance in Adolescents with Obesity
    ESTELLE DE GROOTE, FLORIAN A. BRITTO, LOÏC BULLOCK, MARIE FRANÇOIS, CARINE DE BUCK, HENRI NIELENS, LOUISE DELDICQUE
    Medicine & Science in Sports & Exercise.2018; 50(11): 2200.     CrossRef
  • Lipid modulation of skeletal muscle mass and function
    Christopher Lipina, Harinder S Hundal
    Journal of Cachexia, Sarcopenia and Muscle.2017; 8(2): 190.     CrossRef
  • Angiotensin-Converting Enzyme Ins/Del Polymorphism and Body Composition: The Intermediary Role of Hydration Status
    Laura Bordoni, Valerio Napolioni, Francesca Marchegiani, Emilio Amadio, Rosita Gabbianelli
    Lifestyle Genomics.2017; 10(1-2): 1.     CrossRef
  • Influence of segmental body composition and adiposity hormones on resting metabolic rate and substrate utilization in overweight and obese adults
    K. R. Hirsch, A. E. Smith-Ryan, M. N. M. Blue, M. G. Mock, E. T. Trexler
    Journal of Endocrinological Investigation.2017; 40(6): 635.     CrossRef
  • Carbohydrate-Restriction with High-Intensity Interval Training: An Optimal Combination for Treating Metabolic Diseases?
    Monique E. Francois, Jenna B. Gillen, Jonathan P. Little
    Frontiers in Nutrition.2017;[Epub]     CrossRef
  • Mediterranean diet and mortality risk in metabolically healthy obese and metabolically unhealthy obese phenotypes
    Y-M Park, S E Steck, T T Fung, J Zhang, L J Hazlett, K Han, A T Merchant
    International Journal of Obesity.2016; 40(10): 1541.     CrossRef
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    Diabetes & Metabolism Journal.2016; 40(5): 386.     CrossRef

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