- Pathophysiology
- Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance
-
Yajie Fan, Zhipeng Yan, Tingting Li, Aolin Li, Xinbiao Fan, Zhongwen Qi, Junping Zhang
-
Diabetes Metab J. 2024;48(1):19-36. Published online January 3, 2024
-
DOI: https://doi.org/10.4093/dmj.2023.0110
-
-
6,413
View
-
293
Download
-
7
Web of Science
-
8
Crossref
-
 Abstract
 PDF PubReader  ePub
- Insulin resistance has been regarded as a hallmark of diabetes heart disease (DHD). Numerous studies have shown that insulin resistance can affect blood circulation and myocardium, which indirectly cause cardiac hypertrophy and ventricular remodeling, participating in the pathogenesis of DHD. Meanwhile, hyperinsulinemia, hyperglycemia, and hyperlipidemia associated with insulin resistance can directly impair the metabolism and function of the heart. Targeting insulin resistance is a potential therapeutic strategy for the prevention of DHD. Currently, the role of insulin resistance in the pathogenic development of DHD is still under active research, as the pathological roles involved are complex and not yet fully understood, and the related therapeutic approaches are not well developed. In this review, we describe insulin resistance and add recent advances in the major pathological and physiological changes and underlying mechanisms by which insulin resistance leads to myocardial remodeling and dysfunction in the diabetic heart, including exosomal dysfunction, ferroptosis, and epigenetic factors. In addition, we discuss potential therapeutic approaches to improve insulin resistance and accelerate the development of cardiovascular protection drugs.
-
Citations
Citations to this article as recorded by  - Different Associations between Lipid Levels and Risk for Heart Failure according to Diabetes Progression
Seung-Hwan Lee, Kyu Na Lee, Jong-Chan Youn, Hun Sung Kim, Kyungdo Han, Mee Kyoung Kim
Diabetes & Metabolism Journal.2025; 49(1): 105. CrossRef - Association between METS-IR and heart failure: a cross-sectional study
Xiaozhou Su, Chunli Zhao, Xianwei Zhang
Frontiers in Endocrinology.2024;[Epub] CrossRef - Insulin–Heart Axis: Bridging Physiology to Insulin Resistance
Alfredo Caturano, Raffaele Galiero, Erica Vetrano, Celestino Sardu, Luca Rinaldi, Vincenzo Russo, Marcellino Monda, Raffaele Marfella, Ferdinando Carlo Sasso
International Journal of Molecular Sciences.2024; 25(15): 8369. CrossRef - The web of intrigue: unraveling the role of NETosis within the gut-microbiome-immune-heart axis in acute myocardial infarction and heart failure
Tai Yasuda, Kate Deans, Aditi Shankar, Robert Chilton
Cardiovascular Endocrinology & Metabolism.2024;[Epub] CrossRef - Relationship between the Mediterranean Diet and Vascular Function in Subjects with and without Increased Insulin Resistance
Marta Gómez-Sánchez, Leticia Gómez-Sánchez, Rocío Llamas-Ramos, Emiliano Rodríguez-Sánchez, Luis García-Ortiz, Ruth Martí-Lluch, María Cortés Rodríguez, Inés Llamas-Ramos, Manuel A. Gómez-Marcos
Nutrients.2024; 16(18): 3106. CrossRef - Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects
Qin Ru, Yusheng Li, Lin Chen, Yuxiang Wu, Junxia Min, Fudi Wang
Signal Transduction and Targeted Therapy.2024;[Epub] CrossRef - The Role of Insulin Within the Socio-Psycho-Biological Framework in Type 2 Diabetes—A Perspective from Psychoneuroimmunology
Anne Wevers, Silvia San Roman-Mata, Santiago Navarro-Ledesma, Leo Pruimboom
Biomedicines.2024; 12(11): 2539. CrossRef - Targeting Cardiac Fibrosis in Diabetic Heart Failure: The Role of the EZH2, AMPK, and PPAR-γ Pathways (Diabetes Metab J 2024;48:716-29)
Jooyeop Lee, Joon Ho Moon
Diabetes & Metabolism Journal.2024; 48(6): 1176. CrossRef
|
KDA
