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Tiziana Bacchetti  (Bacchetti T) 1 Article
Clinical Diabetes & Therapeutics
Three Months Monitored Metabolic Fitness Modulates Cardiovascular Risk Factors in Diabetic Patients
Ilenia Cirilli, Sonia Silvestri, Fabio Marcheggiani, Fabiola Olivieri, Roberta Galeazzi, Roberto Antonicelli, Rina Recchioni, Fiorella Marcheselli, Tiziana Bacchetti, Luca Tiano, Patrick Orlando
Diabetes Metab J. 2019;43(6):893-897.   Published online June 27, 2019
DOI: https://doi.org/10.4093/dmj.2018.0254
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  • 7 Web of Science
  • 6 Crossref
AbstractAbstract PDFPubReader   

Cardiovascular diseases represent the leading cause of death and moderate physical exercise is associated with a reduction in cardiovascular risk. The aim of the study was to evaluate the correlation between the amount of exercise recorded daily by a wearable gravitometer for 3 months and selected biochemical and clinical parameters. Nineteen sedentary type 2 diabetics were recruited and distributed into three homogenous groups, low, medium, and high exercise, according to the level of physical exercise monitored and expressed as MOVEs. Data showed an inverse correlation between MOVEs and oxidative stress indexes and a significant improvement in paraoxonase-1 activities and endothelial functionality. Decrease of visceral/total adipose tissue ratio, systolic blood pressure and a down-regulation of the inflammatory microRNA-146a in high exercise group were observed. Finally, a decrease of glycosylated hemoglobin and an up-regulation of the angiogenic microRNA-130a in medium exercise one was obtained. In this study, precise daily monitoring permitted to underline the importance of the amount of physical activity to counteract some cardiovascular risk factors persisting in diabetes. Finally, it identifies new microRNA biomarkers for future investigation on the same topic.

Citations

Citations to this article as recorded by  
  • Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus
    Dharmsheel Shrivastav, Desh Deepak Singh
    World Journal of Clinical Cases.2024; 12(3): 525.     CrossRef
  • Effects of Seven Weeks of Combined Physical Training on High-Density Lipoprotein Functionality in Overweight/Obese Subjects
    Tiziana Bacchetti, Camilla Morresi, Gianna Ferretti, Anders Larsson, Torbjörn Åkerfeldt, Michael Svensson
    Metabolites.2023; 13(10): 1068.     CrossRef
  • Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases
    Juan Gao, Xue Pan, Guoping Li, Emeli Chatterjee, Junjie Xiao
    Journal of Cardiovascular Translational Research.2022; 15(3): 604.     CrossRef
  • Effects of Exercise Training on the Paracrine Function of Circulating Angiogenic Cells
    William S. Evans, Ryan M. Sapp, Katherine I. Kim, James M. Heilman, James Hagberg, Steven J. Prior
    International Journal of Sports Medicine.2021; 42(12): 1047.     CrossRef
  • Chronic and Transient Hyperglycemia Induces Changes in the Expression Patterns of IL6 and ADIPOQ Genes and Their Associated Epigenetic Modifications in Differentiating Human Visceral Adipocytes
    Adam Wróblewski, Justyna Strycharz, Ewa Świderska, Aneta Balcerczyk, Janusz Szemraj, Józef Drzewoski, Agnieszka Śliwińska
    International Journal of Molecular Sciences.2021; 22(13): 6964.     CrossRef
  • The Potential Role of MicroRNA in Diabetic Cardiomyopathy
    Jin Hwa Kim
    Diabetes & Metabolism Journal.2020; 44(1): 54.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal