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Tarik Becic  (Becic T) 2 Articles
Clinical Diabetes & Therapeutics
Effects of Omega-3 Supplementation on Adipocytokines in Prediabetes and Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Tarik Becic, Christian Studenik
Diabetes Metab J. 2018;42(2):101-116.   Published online April 19, 2018
DOI: https://doi.org/10.4093/dmj.2018.42.2.101
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  • 16 Web of Science
  • 17 Crossref
AbstractAbstract PDFPubReader   
Background

The objective of this systematic review and meta-analysis was to determine the effects of omega-3 supplementation on adipocytokine levels in adult prediabetic and diabetic individuals.

Methods

We searched PubMed, Medline, EMBASE, Scopus, Web of Science, Google Scholar, Cochrane Trial Register, World Health Organization Clinical Trial Registry Platform, and Clinicaltrial.gov Registry from inception to August 1, 2017 for randomized controlled trials. Pooled effects of interventions were assessed as mean difference using random effects model. We conducted a sensitivity, publication bias and subgroup analysis.

Results

Fourteen studies individuals (n=685) were included in the meta-analysis. Omega-3 supplementation increased levels of adiponectin (0.48 µg/mL; 95% confidence interval [CI], 0.27 to 0.68; P<0.00001, n=10 trials), but effects disappeared after sensitivity analysis. Tumor necrosis factor α (TNF-α) levels were reduced (−1.71; 95% CI, −3.38 to −0.14; P=0.03, n=8 trials). Treatment duration shorter than 12 weeks was associated with greater reduction than longer treatment duration. Levels of other adipocytokines were not significantly affected. Publication bias could generally not be excluded.

Conclusion

Eicosapentaenoic acid and docosahexaenoic acid supplementation may increase adiponectin and reduce TNF-α levels in this population group. However, due to overall study heterogeneity and potential publication bias, a cautious interpretation is needed.

Citations

Citations to this article as recorded by  
  • The Effects of Omega-3 Fatty Acid Supplementation on the Lipid Profile and Cardiovascular Markers Following Downhill Running in Long-Distance Runners
    Marzena Jaworska, Szymon Siatkowski, Aleksandra Żebrowska
    Journal of Human Kinetics.2023; 89: 123.     CrossRef
  • Omega-3 supplementation in the treatment of polycystic ovary syndrome (PCOS) – a review of clinical trials and cohort
    Vitoria Melo, Thomas Silva, Thaissa Silva, Juliana Freitas, Joselita Sacramento, Mirian Vazquez, Edilene Araujo
    Endocrine Regulations.2022; 56(1): 66.     CrossRef
  • The effects of omega-3 fatty acids in type 2 diabetes: A systematic review and meta-analysis
    Yanan Xiao, Qifang Zhang, Xueling Liao, Ulf Elbelt, Karsten H. Weylandt
    Prostaglandins, Leukotrienes and Essential Fatty Acids.2022; 182: 102456.     CrossRef
  • Anti-inflammatory and antioxidant activity of astragalus polysaccharide in ulcerative colitis: A systematic review and meta-analysis of animal studies
    Heng-Chang Hu, Wei Zhang, Pei-Yu Xiong, Li Song, Bo Jia, Xing-Long Liu
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Eicosopenthaenoic acid: Gnawing at the perivascular adipose tissue
    Paolo Raggi, Arthur E. Stillman
    Atherosclerosis.2021; 316: 69.     CrossRef
  • The Effect of Omega-3 Fatty Acid Supplementation on Serum Adipocytokines, Lipid Profile and Biochemical Markers of Inflammation in Recreational Runners
    Aleksandra Żebrowska, Barbara Hall, Anna Stolecka-Warzecha, Arkadiusz Stanula, Ewa Sadowska-Krępa
    Nutrients.2021; 13(2): 456.     CrossRef
  • The Influence of Nutrition on Adiponectin—A Narrative Review
    Justyna Janiszewska, Joanna Ostrowska, Dorota Szostak-Węgierek
    Nutrients.2021; 13(5): 1394.     CrossRef
  • Adiponectin’s roles in lipid and glucose metabolism modulation in fish: Mechanisms and perspectives
    Renlei Ji, Xiang Xu, Giovanni M. Turchini, Kangsen Mai, Qinghui Ai
    Reviews in Aquaculture.2021; 13(4): 2305.     CrossRef
  • Omega-3 Fatty Acids and Vulnerability to Addiction: Reviewing Preclinical and Clinical Evidence
    Valerie L. Darcey, Katherine M. Serafine
    Current Pharmaceutical Design.2020; 26(20): 2385.     CrossRef
  • Therapeutic effects of different doses of prebiotic (isolated from Saccharomyces cerevisiae) in comparison to n-3 supplement on glycemic control, lipid profiles and immunological response in diabetic rats
    Janina de Sales Guilarducci, Breno Augusto Ribeiro Marcelino, Isaac Filipe Moreira Konig, Tamira Maria Orlando, Mary Suzan Varaschin, Luciano José Pereira
    Diabetology & Metabolic Syndrome.2020;[Epub]     CrossRef
  • Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments
    Gerwyn Morris, Basant K. Puri, Lisa Olive, Andre Carvalho, Michael Berk, Ken Walder, Lise Tuset Gustad, Michael Maes
    BMC Medicine.2020;[Epub]     CrossRef
  • Evaluation of walking exercise on glycemic control in patients with type 2 diabetes mellitus
    Hengchang Hu, Yuanhong Lei, Liping Yin, Xiaoqiong Luo
    Medicine.2020; 99(47): e22735.     CrossRef
  • Omega-3 polyunsaturated fatty acids in supporting pregnancy and fetal development: dosing considerations
    Olga A. Gromova, Ivan Iu. Torshin, Tatiana R. Grishina, Svetlana I. Maliavskaia
    Gynecology.2020; 22(5): 61.     CrossRef
  • A Significant Association Between Rhein and Diabetic Nephropathy in Animals: A Systematic Review and Meta-Analysis
    Heng-Chang Hu, Liu-Tao Zheng, Hai-Yan Yin, Yuan Tao, Xiao-Qiong Luo, Kai-Shan Wei, Li-Ping Yin
    Frontiers in Pharmacology.2019;[Epub]     CrossRef
  • Dietary n-3 polyunsaturated fatty acids, fish intake and healthy ageing
    Esther García-Esquinas, Rosario Ortolá, Jose Ramón Banegas, Esther Lopez-García, Fernando Rodríguez-Artalejo
    International Journal of Epidemiology.2019; 48(6): 1914.     CrossRef
  • Beneficial Effects of Adiponectin on Glucose and Lipid Metabolism and Atherosclerotic Progression: Mechanisms and Perspectives
    Hidekatsu Yanai, Hiroshi Yoshida
    International Journal of Molecular Sciences.2019; 20(5): 1190.     CrossRef
  • Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases
    Ying Liu, Vivian Vu, Gary Sweeney
    Frontiers in Endocrinology.2019;[Epub]     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal